| 22nd week of 2009 patent applcation highlights part 47 |
| Patent application number | Title | Published |
|---|
| 20090137781 | Method and Device for Producing a Thread from Silk Proteins - The present invention relates to a thread preparation process from silk proteins including an apparatus which is appropriate for performing the method. Furthermore, the invention is directed to the threads obtained therewith as well as the use thereof. The invention uses a diffusion unit leading to the production of high-quality silk threads with high yield. | 2009-05-28 |
| 20090137782 | SPECIFIC BINDING PROTEINS AND USES THEREOF - The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806. | 2009-05-28 |
| 20090137783 | CNGH0010 Specific Polynucleotides, Polypeptides, Antibodies, Compositions, Methods and Uses - Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases. | 2009-05-28 |
| 20090137784 | Epidermal Growth Factor Receptor Polypeptides and Antibodies - Antibodies and polypeptides that bind to and/or modulate the activity of receptors in the epidermal growth factor family are provided herein. | 2009-05-28 |
| 20090137785 | RAB9 PROTEIN CRYSTAL STRUCTURES AND METHODS FOR IDENTIFYING RAB9 MODULATORS - The present invention relates to crystalline Rab9 in complex with either GDP or the GTP analog Guanosine 5′-(β,γ-imido) triphosphate (GppNHp), the three dimensional coordinates and structures of Rab9 in Rab9-GDP and Rab9-GppNHp complexes, and uses thereof for drug design. In particular, the present invention relates to methods for producing Rab9 crystals of sufficient quality to obtain a determination of the three dimensional structure of Rab9 to a high resolution in both its GTP-bound (on/active) and GDP-bound (off/inactive) conformations. The present invention also relates to a computer-readable medium encoded with the three dimensional coordinates of Rab9 in Rab9-GDP and Rab9-GppNHp complexes wherein, using a graphical display software program, the three dimensional coordinates create an electronic file that can be visualized on a computer capable of representing the electronic file as a three dimensional image. | 2009-05-28 |
| 20090137786 | Method for producing reduced keratin, reduced cuticle protein and mixture thereof - A method for producing a reduced keratin solution, a powder of reduced keratin, a reduced cuticle protein dispersion, an aqueous medium dispersion containing reduced keratin and reduced cuticle protein, or a mixed powder of reduced keratin and reduced cuticle protein, comprising the extraction step of dipping and heating a keratin-containing substance in an aqueous medium containing a reducing agent and a surface active agent, without using a protein denaturing agent, such as urea, to extract the water-soluble component contained in the keratin-containing substance into the aqueous medium. | 2009-05-28 |
| 20090137787 | JANUS FAMILY KINASES AND IDENTIFICATION OF IMMUNE MODULATORS - An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing. | 2009-05-28 |
| 20090137788 | USPA1 AND USPA2 ANTIGENS OF MORAXELLA CATARRHALIS - The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of | 2009-05-28 |
| 20090137789 | Oligonucleotide Probes - Fluorescent oligonucleotide probe having a general formula (I), wherein Onu represents an oligonucleotide residue, Thio | 2009-05-28 |
| 20090137790 | METHOD OF CAPPING OLIGONUCLEIC ACID - The present invention relates to a method for producing an oligonucleic acid derivative characterized by using a phenoxyacetic acid derivative anhydride as an acylating agent and a pyridine derivative as the acylation reaction activator, in a capping step for protecting the 5′-hydroxyl group of a ribose of an oligonucleic acid derivative. | 2009-05-28 |
| 20090137791 | METHODS OF ATTACHING BIOLOGICAL COMPOUNDS TO SOLID SUPPORTS USING TRIAZINE - Disclosed are methods of attaching biologically active compounds to a solid surface, comprising modifying the solid surface using triazine chloride and attaching the biologically active compound to the triazine moiety. | 2009-05-28 |
| 20090137792 | Production Of L-Iduronate Containing Polysaccharides - The present invention provides processes for the production of polysaccharides containing the L-iduronate subunit, for example, heparin-type polysaccharides. New intermediate compounds and processes developed during the production of said polysaccharides are also presented. | 2009-05-28 |
| 20090137793 | DISACCHARIDE COMPOUNDS - Disaccharide compounds used as building blocks for making heparin and heparan sulfate oligosaccharides. Also disclosed are methods for making these disaccharide compounds. | 2009-05-28 |
| 20090137794 | Processes for the synthesis of rocuronium bromide - The invention encompasses processes for synthesizing 1-[17β-acetyloxy-3α-hydroxy-2β-(4-morpholinyl)-5α-androstan-16β-yl]-1-(2-propenyl)pyrrolidinium bromide (rocuronium bromide) and intermediates thereof. | 2009-05-28 |
| 20090137795 | NEW ROUTE TO FORMYL-PORPHYRINS - A method of making a 5-formylporphyrin, comprises the steps of: condensing a 5-acetaldipyrromethane with a dipyrromethane-1,9-dicarbinol to produce a porphyrin having an acetal group substituted thereon at the 5 position; and then hydrolyzing said porphyrin to produce said 5-formylporphyrin. Products and intermediates useful in such methods, along with methods of making such intermediates, are also described. | 2009-05-28 |
| 20090137796 | METHODS FOR THE PREPARATION OF TAXANES USING CHIRAL AUXILIARIES - The present invention relates to a stereoselective synthesis of novel β-lactam dimers as useful precursors for the preparation of paclitaxel, docetaxel, and analogues thereof. More particularly, the new β-lactams are prepared from readily available and enantiomerically pure chiral auxiliaries. The β-lactams are then reacted with a suitably protected taxane to produce diastereomerically enriched side chain-bearing taxanes. Finally, the chiral auxiliary is cleaved and protecting groups are removed to provide the desired taxane. | 2009-05-28 |
| 20090137797 | Organic Compounds - A process for preparing compounds of formula (I) or a solvate or hydrate thereof, where R, R | 2009-05-28 |
| 20090137798 | Process for the Preparation of Delmopinol and Derivatives Thereof - A process for the preparation of delmopinol (3-(4-propylheptyl)-4-morpholinethanol) or a derivative or a pharmaceutically acceptable salt, or a solvate thereof, including an hydrate, comprises reacting oxazolidin [2, 3-c] morpholine and a grignard reagent, and optionally converting the delmopinol (or derivative) free base into a pharmaceutically acceptable salt. The oxazolidin [2, 3-c] morpholine and the grignard reagent are useful as intermediates in the production process. | 2009-05-28 |
| 20090137799 | Cycloalkylcarbonylamino Acid Ester Derivative and Process for Producing The Same - Cycloalkylcarbonylamino acid ester derivatives, which are raw material intermediates for a novel cycloalkane carboxamide derivative having an action that selectively inhibits cathepsin K, and a production process thereof, are provided. | 2009-05-28 |
| 20090137800 | NOVEL COMPOUND, OPTICAL FILTER AND OPTICAL RECORDING MATERIAL USING THE SAME - A compound represented by the following general formula (I), | 2009-05-28 |
| 20090137801 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS - Disclosed are substituted xanthines of the formula | 2009-05-28 |
| 20090137802 | A2B ADENOSINE RECEPTOR ANTAGONISTS - Disclosed are processes for the synthesis of novel compounds that are A | 2009-05-28 |
| 20090137803 | 5-PROTECTED AMINOPYRIMIDINE COMPOUND, PRODUCTION METHOD THEREOF AND INTERMEDIATE THEREFOR - The present invention provides a production method of 5-aminopyrimidine compound represented by the formula (5) by reacting a glycine compound represented by the formula (1) with t-butoxybisdimethylaminomethane, dimethylformamidedimethylacetal or dimethylformamidediethylacetal to produce a dialkylaminomethylene compound represented by the formula (2), reacting the compound of formula (2) in the presence of an acid to produce a hydroxymethylene compound represented by the formula (3), and reacting the compound of formula (3) with an amidine compound represented by the formula (4) or a salt thereof. | 2009-05-28 |
| 20090137804 | Compounds and Compositions as Protein Kinase Inhibitors - The invention relates to compounds of formula (I) | 2009-05-28 |
| 20090137805 | N-PHENYL-2-PYRIMIDINE-AMINE DERIVATIVES - The present invention relates to novel amides and a process for preparing these amides. | 2009-05-28 |
| 20090137806 | DUAL NK1/NK3 RECEPTOR ANTAGONISTS - The present invention provides a method for the treatment of schizophrenia which comprises administering a compound of formula | 2009-05-28 |
| 20090137807 | Electrochromic material with improved lifetime - Disclosed are viologen derivatives as an electrochromic material having improved stability and lifetime, a metal oxide electrode including the same, and an electrochromic device using the viologen derivative as an electrochromic material. The viologen derivative includes a suitable regulator group capable of increasing ΔE that is a potential difference between E | 2009-05-28 |
| 20090137808 | PROCESS FOR MANUFACTURING BISPHOSPHONIC ACIDS - A manufacturing process for the preparation of bisphosphonic acids and in particular zoledronic acid is provided wherein diglyme, monoglyme, or a mixture thereof, is utilized to produce a homogenous, water soluble, solid reaction mass that upon cooling, dissolving in water and stripping results in a high purity product and comparatively good yield. wherein Ri is selected from the group consisting of | 2009-05-28 |
| 20090137809 | Demethylation of 14 hydroxy substituted alkaloid derivatives - The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5-epoxymorphinane-6-on-derivatives. This is achieved by reacting a starting compound with a compound of general formula R | 2009-05-28 |
| 20090137810 | Synthetic Methods and Intermediates for Stereoisomeric Compounds Useful for the Treatment of Gastrointestinal and Central Nervous System Disorders - The subject invention provides methods and/or processes for making stereoisomeric compounds of formula (X): | 2009-05-28 |
| 20090137811 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL - The present invention relates to a new process for the preparation of intermediate compounds useful in the manufacture of donepezil, or a pharmaceutically-acceptable salt thereof, and also relates to processes for preparing donepezil and to the novel intermediates per se. In addition the invention relates to various hydrated forms of donepezil. | 2009-05-28 |
| 20090137812 | PROCESS FOR PRODUCING 1-BENZYL-4-[5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE OR ITS SALT THEREOF VIA NOVEL INTERMEDIATE - Disclosed herein the process for producing 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2yl)methyl]piperidine or its salt thereof employing novel intermediates. | 2009-05-28 |
| 20090137813 | PROCESS FOR PRODUCTION OF CAREBASTINE - Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: | 2009-05-28 |
| 20090137814 | Synthesis of diaminodinitropyridine - A process for the preparation of diaminodinitropyridine or diaminodinitrobenzene by contacting an aminopyridine or aminobenzene with oleum and nitric acid, wherein the improvement comprises adding at least about 1% molar excess of nitric acid, based upon the aminopyridine or aminobenzene, with stirring for at least two hours to form first the intermediate sulfonic acid, and then diaminodinitropyridine or diaminodinitrobenzene, and use of such products in the preparation of rigid rod polymers is disclosed. | 2009-05-28 |
| 20090137815 | Process for Making Cytokine Inhibiting Compounds Containing 4- and 5-Imidazolyl Rings and the Intermediates Thereof - Disclosed are processes for making compounds containing 4- and 5-imidazolyl rings, also disclosed are the inter-mediates useful in the processes disclosed herein. | 2009-05-28 |
| 20090137816 | Process for the manufacture of diaminofurazan - This invention consists of a method for converting diaminoglyoxime to diaminofurazan that can be carried out efficiently at about atmospheric pressure without the need for high pressure containment apparatus. | 2009-05-28 |
| 20090137817 | SPATIALLY-DEFINED MACROCYCLIC COMPOUNDS USEFUL FOR DRUG DISCOVERY - Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor. | 2009-05-28 |
| 20090137818 | Crystal structure of human coronavirus 229E main proteinase and uses for developing SARS inhibitors - The invention relates to a method of developing a main proteinase SARS inhibitor. Human coronaviruses are major causes of upper respiratory tract illnesses in humans, in particular, the common cold. Recent investigations have shown that a novel coronavirus causes the Severe Acute Respiratory Syndrome (SARS), a disease that is characterized by high fever, malaise, rigor, headache, non-productive cough or dyspnea, which is rapidly spreading. Within the scope of the invention, based on the structural analysis of the binding mode of the SARS M | 2009-05-28 |
| 20090137819 | Method of Producing Optically Active 4-Amino-3-Substituted Phenylbutanoic Acid - The present invention provides a method of producing a compound (IIa) or a compound (IIb), provides a method of producing a compound (IIIa) or a compound (IIIb), provides a method of producing a compound (Va) or its salt or a compound (Vb) or its salt, provides a method of producing a compound (IIIa) or a compound (IIIb), further, provides a method of producing a compound (Va) or its salt or a compound (Vb) or its salt including these production methods. | 2009-05-28 |
| 20090137820 | PROCESS FOR PRODUCTION OF METHYLENE DISULFONATE COMPOUND - The present invention provides a process for producing a methylene disulfonate compound in a simple manner at low cost. | 2009-05-28 |
| 20090137821 | Method of making dorzolamide hydrochloride - Processes for the preparation of dorzolamide hydrochloride and an intermediate of Formula IV, | 2009-05-28 |
| 20090137822 | Process for preparing 3-substituted thiophene - The present invention relates to a process for preparing a 3-substituted thiophene represented by the formula (2): | 2009-05-28 |
| 20090137823 | (E)-N-Monoalkyl-3-Oxo-3-(2-Thienyl) Propenamine and Process for Producing the Same and Process for Producing (E,Z)-N-Monoalkyl-3-Oxo-3-(2-Thienyl) Propenamine - The present invention provides a process for producing (E)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by Formula (1); | 2009-05-28 |
| 20090137824 | METALLOCENE-BASED PHOSPHORUS CHIRAL PHOSPHINES - The present invention concerns a metallocene-based phosphine ligand for use in enantioselective catalysis, the ligand having the Formula (I): Wherein M is a metal; Z is P or As; L is a suitable linker; R | 2009-05-28 |
| 20090137825 | METHOD OF PRODUCING A CARBOXYLIC ALKYL ESTER - The present invention relates to a novel process for preparing alkyl polycarboxylates from an aqueous solution of an ammonium salt of the polycarboxylic acid by reactive distillation, and to a process for hydrogenating the alkyl carboxylates prepared in this way. | 2009-05-28 |
| 20090137826 | Method for preparing 4beta-amino-4'-demethyl-4-desoxypodophyllotoxin - The invention relates to a method for synthesizing 4β-amino-4′-demethyl-4-desoxypodophyllotoxin of formula (1), characterized by comprising the following successive steps: a) reacting, in a pure weak acid or in a mixture consisting of acid, water and of organic solvent, without another solvent, at a temperature higher than the ambient temperature, thiourea with 4β-halogenoacetamido-4′-demethyl-4-desoxypodophyllotoxin, and; b) recovering the 4β-amino-4′-demethyl-4-desoxypodophyllotoxin. | 2009-05-28 |
| 20090137827 | SILICON-TITANIUM MIXED OXIDE-CONTAINING DISPERSION FOR THE PRODUCTION OF TITANIUM-CONTAINING ZEOLITES - Dispersion containing pyrogenic silicon-titanium mixed oxide powders with a silicon dioxide content of 75 to 99.99 wt.-% and a titanium dioxide content of 0.01 to 25 wt. %, water and a basic, quaternary ammonium compound, wherein the mean aggregate diameter of the particles of the silicon-titanium mixed oxide powder in the dispersion is 200 nm at most. Process for the production of a titanium-containing zeolite with the use of the dispersion. | 2009-05-28 |
| 20090137828 | Synthesis of 1A-Fluoro-25-Hydroxy-16-23E-Diene-26,27-Bishomo-20-Epi-Cholecalciferol - The invention provides a method of producing 20-methyl vitamin D3 compounds of formula (I). The method includes allylic and olefin oxidation, de-carbonylation, carbonyl reduction, fluoride substitution, epoxide deoxygenation, and Wittig-type couplings. | 2009-05-28 |
| 20090137829 | Methods for Preparation and Use of Strong Base Catalysts - Methods for preparation of a unique superbase catalyst consisting of mixture of polyether alcohol and base in which a polyether alcohol superbase is produced by the removal of water or alcohol at elevated temperatures to form a polyether alcohol alkoxide. The superbase catalyst is useful in, but not limited to, quantitative isomerization of alkyl esters of vegetable oils containing interrupted double bond systems to yield esters with conjugated double bond systems, alkylations, arylations, acylations, aminations, condensations, eliminations, isomerizations, rearrangements, and Wittig reactions. | 2009-05-28 |
| 20090137830 | Process for the preparation of a metal-organic compound comprising a spectator ligand - The invention relates to a process for the production of an organometallic compound according to formula (1): MAL | 2009-05-28 |
| 20090137831 | Fluorinated Alkanesulfonic Acid Esters and Amides and Processes for Making and Using the Same - The invention provides novel aryl and aliphatic esters of fluorinated alkanesulfonic acids. The invention also provides novel fluorinated alkanesulfonamides and a process to make the same. The invention also provides a process for the arylation of an amine by contacting the amine with an aryl ester of a fluorinated alkanesulfonic acid. | 2009-05-28 |
| 20090137832 | PROCESSES FOR PURIFYING DIARYL CARBONATES - Processes comprising: transesterifying a dialkyl carbonate and an aromatic hydroxyl compound in the presence of a transesterification catalyst to provide a diaryl carbonate product comprising the transesterification catalyst as an impurity; subjecting the diaryl carbonate product to distillation in a first distillation column having an upper part and a lower part, wherein the upper part comprises a rectifying section and the lower part comprises a stripping section; and withdrawing a first sidestream from the first distillation column, wherein the first sidestream comprises a purified diaryl carbonate. | 2009-05-28 |
| 20090137833 | Process for industrially producing dialkyl carbonate and diol - It is an object of the present invention to provide a specific process that enables a dialkyl carbonate and a diol to be produced on an industrial scale of not less than 2 ton/hr and not less than 1.3 ton/hr respectively with high selectivity and high productivity stably for a prolonged period of time through a reactive distillation system of taking a cyclic carbonate and an aliphatic monohydric alcohol as starting materials, continuously feeding the starting materials into a continuous multi-stage distillation column in which a catalyst is present, and carrying out reaction and distillation simultaneously in the column. Although there have been many proposals regarding processes for the production of the dialkyl carbonate and the diol through the reactive distillation method, these have all been on a small scale and short operating time laboratory level, and there have been no disclosures whatsoever on a specific process or apparatus enabling mass production on an industrial scale. According to the present invention, there is provided a specific continuous multi-stage distillation column having a specified structure, and a production process using this continuous multi-stage distillation column, according to which the dialkyl carbonate and the diol can be produced on an industrial scale of not less than 2 ton/hr and not less than 1.3 ton/hr respectively each with a selectivity of not less than 95%, preferably not less than 97%, more preferably not less than 99%, stably for not less than 1000 hours, preferably not less than 3000 hours, more preferably not less than 5000 hours. | 2009-05-28 |
| 20090137834 | LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF - Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. | 2009-05-28 |
| 20090137835 | PROCESSES FOR INTERMEDIATES FOR MACROCYCLIC COMPOUNDS - The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: | 2009-05-28 |
| 20090137836 | PROCESSES FOR PREPARING LOW-ACID POLYALKYLENE TEREPHTHALATE FROM DIOL-CAPPED PRE-POLYMER AND LINEAR OLIGOMER RECYCLATE AND USING SUCH IN THE PRODUCTION OF MACROCYCLIC POLYESTER OLIGOMER - The invention relates to a method for producing low-acid polyalkylene terephthalate from which MPO can be advantageously manufactured. In certain embodiments, low-acid polybutylene terephthalate (PBT) is prepared by reacting low molecular weight, diol-stopped PBT pre-polymer with a linear oligomer recyclate in refluxing ortho-dichlorobenzene (oDCB) solvent. The linear oligomer recyclate may be a by-product of the depolymerization/cyclization of the low-acid PBT, thereby synergistically increasing overall conversion of reactants to the MPO product, cyclic polybutylene terephthalate (cPBT). | 2009-05-28 |
| 20090137837 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF - Methods of preparing cinacalcet, cinacalcet derivatives, and salts thereof is disclosed herein. Also disclosed herein are polymorphs of cinacalcet, compositions of cinacalcet, and methods of treating a subject by administering cinacalcet, wherein cinacalcet is prepared by the disclosed methods. | 2009-05-28 |
| 20090137838 | Esters with antimicrobial, bioresistant and fungal resistant properties - A bromine/nitro moiety linked into the backbone of an ester or other compound over a wide range of occurrence rates provides antimicrobial, bio-resistant and fungal resistant properties for metal working fluids (MWF)s and other coatings. The moiety can be have the bromo and nitro groups linked to the same or different carbon atoms. The present invention also relates to urethanes, urea, amides, imides, carbonates, ethers, siloxanes, and many other types of linkages essential to MWF bases. | 2009-05-28 |
| 20090137839 | METHOD FOR PRODUCING (2-FORMYL-1-ALKENYL) CYCLOPROPANE COMPOUND - A method for producing a (2-formyl-1-alkenyl)cyclopropane compound represented by the formula (1): | 2009-05-28 |
| 20090137840 | Fluorinated Alkanesulfonic Acid Anhydrides and Processes for Making the Same - The invention provides a process for the preparation of fluorinated alkanesulfonic acid anhydrides by contacting alkanesulfonic acids with phosphorus pentoxide, the phosphorus pentoxide being provided as a dispersion in an inert oil. The invention also provides novel fluorinated alkanesulfonic acid anhydrides including 2-hydrotetrafluoroethanesulfonic acid anhydride. | 2009-05-28 |
| 20090137841 | PROCESS FOR THE PREPARATION OF AROMATIC DERIVATIVES OF 1-ADAMANTANE - Process for the obtaining of 1-adamantane (tricycle[3.3.1.1 (3,7)]decane) derivatives, or of a pharmaceutically acceptable salt thereof, based on a carboxylation reaction, via metallation, of a precursor compound with an adequate leaving group. It also comprises the preparation of the precursor compound by means of a selective coupling of the corresponding boron, magnesium or zinc derivative with the corresponding disubstitute aromatic derivative. It is especially useful for the obtaining of Adapalene at industrial scale with good yield and high purity. | 2009-05-28 |
| 20090137842 | PREGABALIN -4-ELIMINATE, PREGABALIN 5-ELIMINATE, THEIR USE AS REFERENCE MARKER AND STANDARD, AND METHOD TO PRODUCE PREGABALIN CONTAINING LOW LEVELS THEREOF - The present invention provides 3-(aminomethyl)-5-methylhex-4-enoic acid (Pregabalin-4-eliminate or PRG-4E) and 3-(aminomethyl)-5-methylhex-5-enoic acid (Pregabalin-5-eliminate or PRG-5E), and their uses as reference markers and standards for determining the purity of Pregabalin. The invention also provides a method to produce Pregabalin containing low levels of these impurities. | 2009-05-28 |
| 20090137843 | METHOD FOR PRODUCING ORGANIC ACID - A novel method is provided whereby a free organic acid can be produced particularly from an ammonium salt of an organic acid having a high melting point obtainable by bioconversion of a carbon source in the presence of a neutralizing agent, efficiently at a low cost, and the used material for reaction and a byproduct can be recycled for reuse without being disposed. | 2009-05-28 |
| 20090137844 | Crystallization process - The invention relates to a process for the production of tamsulosin hydrochloride crystals where the crystal size distribution is controlled by controlling the temperature where hydrochloric acid is added to the reaction mixture. | 2009-05-28 |
| 20090137845 | Novel 4-Dedimethylaminotetracycline derivatives - The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and methods for preparing such compounds. Other tetracycline compounds include the 4-dedimethylaminotetracycline derivatives with an oxime group, NH-Alkyl, or N—NH-Alkyl group substituted at the C4 position as well as C2 Mannich derivatives. The present invention also provides a method of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the new chemically modified tetracycline compounds. | 2009-05-28 |
| 20090137846 | Processes for the synthesis of O-Desmethylvenlafaxine - The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine. | 2009-05-28 |
| 20090137847 | Decomposing system for polyisocyanate residues, and start-up method for the same - An object of the invention is to provide a decomposing system for polyisocyanate residues that is capable of suppressing reaction of polyisocyanate residues with high temperature and high pressure water to allow smooth start-up of the operation, and a start-up method for the decomposing system for the polyisocyanate residues. The decomposing system is used for hydrolyzing the polyisocyanate residues to polyamine using high temperature and high pressure water, comprising a hydrolyzer, a water feed pipe connected to the hydrolyzer, a residual feed pipe connected to the water feed pipe, a solvent feed line for filling an organic solvent in a solvent filling portion of the residual feed pipe, and a solvent draining line. Upon start-up of the operation, the organic solvent is previously filled in the solvent filling portion via the solvent feed line and the solvent draining line, first, and then, the high temperature and high pressure water is fed from the water feed pipe to the hydrolyzer. Then, the organic solvent is fed from the residual feed pipe to the water feed pipe, first, and then, the polyisocyanate residues are fed thereto. | 2009-05-28 |
| 20090137848 | PROCESS FOR THE MANUFACTURE OF POLYPHENOLS - An improved process for the manufacture of a polyphenol compound such as bisphenol-A by introducing into a reaction zone a phenolic compound reactant, a carbonyl compound reactant, and a catalyst promoter comprising bismethylthiopropane added to the reaction system in certain specific locations, and reacting the ingredients within the reaction zone in the presence of an acid catalyst. | 2009-05-28 |
| 20090137849 | METHOD FOR THE SEPARATION OF POLYMERIC BY-PRODUCTS FROM 1,4-BUTYNEDIOL - The present invention relates to processes for making 1,4-butanediol, 1,4-butenediol, or a mixture thereof by processing 1,4-butynediol in a dynamic mixing apparatus in an inert gas atmosphere at from 25 to 150° C. at a shear rate in the radial gap between rotor and stator of the mixing apparatus of more than 100 000 sec | 2009-05-28 |
| 20090137850 | Method for Hydrating Olefins - A novel olefin hydration method is provided for efficiently producing alcohols by hydration of olefins containing 2 to 5 carbon atoms in the presence of a catalyst. Thus, alcohols are produced by hydrating olefins containing 2 to 5 carbon atoms at reaction temperature of 100 to 250° C. in the presence of a solid acid catalyst consisting of carbonaceous materials containing sulfonic acid groups obtained from an organic matter by carbonization and sulfonation. In carrying out this method, the organic matter is preferably an aromatic hydrocarbon or a saccharide, the olefin is preferably propylene or a butenes, and the hydration reaction temperature is not lower than 120° C., more preferably not lower than 150° C. | 2009-05-28 |
| 20090137851 | Purification of glycerin obtained as a bioproduct from the transesterification of triglycerides in the synthesis of biofuel - Methods for purifying glycerin contaminated with one or more lower boiling alcohols such as methanol, ethanol, straight, branched or cyclic C3-C6 alcohols, and the like. The methods are particularly useful for purifying crude glycerin phases recovered from the synthesis of biofuels. The present invention uses distillation techniques to strip alcohol contaminants from glycerin. In contrast to conventional methods that carry out distillation either under substantially anhydrous or very wet conditions, the present invention carries out distillation in the presence of a limited amount of water, e.g., from about 0.8 to about 5 parts by weight of water per 100 parts by weight of contaminated glycerin to be purified. | 2009-05-28 |
| 20090137852 | METHOD FOR PRETREATING AND REGENERATING CATALYSTS USED IN A PROCESS FOR MAKING FLUOROIODOALKANES - A process for the preparation of a fluoroiodoalkane represented by the structural formula CF | 2009-05-28 |
| 20090137853 | Process for the Preparation of 1,1,1,3,3-Penta-Fluoropropane and/or 1,1,1,3,3,3-Hexafluoropropane - A process for the manufacture of CF | 2009-05-28 |
| 20090137854 | Integration of molecular redistribution and hydroisomerization processes for the production of paraffinic base oil - The process as described herein produces a moderately aromatic isoparaffinic base oil from a distillate range product. This process comprises: (a) providing a distillate range paraffin feed comprising paraffins and cycloparaffins; (b) mildly reforming the distillate range paraffin feed to convert at least a portion of the cycloparaffins to alkylaromatics and provide a mildly reformed distillate range stream; (c) treating a stream comprising the mildly reformed distillate range stream in a molecular redistribution reactor to provide a distributed stream; (d) dewaxing at least a portion of the distributed stream to provide a dewaxed stream; (e) combining at least a portion of the dewaxed stream with the stream to be processed in the molecular redistribution reactor to provide the distributed stream; and (f) isolating a moderately aromatic isoparaffinic base oil from the dewaxed stream. According to another aspect, the process generates low ring content isoparaffinic base oil by hydrotreating the moderately aromatic isoparaffinic base oil. | 2009-05-28 |
| 20090137855 | Alkylaromatics Production - A process is described for producing an alkylaromatic compound in a multistage reaction system comprising at least first and second series-connected alkylation reaction zones each containing an alkylation catalyst. A first feed comprising an alkylatable aromatic compound and a second feed comprising an alkene and one or more alkanes are introduced into said first alkylation reaction zone. The operating conditions, e.g. temperature and pressure, of the first alkylation reaction zone are controlled effective to cause the alkylatable aromatic compound to be partly in the vapor phase and partly in the liquid phase, and the ratio of the volume of liquid to the volume of vapor of the feed in each zone to be from about 0.1 to about 10. The aromatic compound and the alkene of the feed are reacted in the presence of the alkylation catalyst to form an effluent comprising the alkylaromatic compound, unreacted alkylatable aromatic compound, any unreacted alkene and the alkane. The effluent is withdrawn from the first alkylation reaction zone and then supplied to the second alkylation reaction zone without removal of the alkane. | 2009-05-28 |
| 20090137856 | METHOD AND DEVICE FOR PRODUCING LOWER OLEFINS FROM OXYGENATES - Method and device for manufacturing at least one low olefin from an oxygenate-containing first reaction mixture ( | 2009-05-28 |
| 20090137857 | METHOD FOR PREPARATION OF ETHYLENE AND PROPYLENE BY CATALYTIC CRACKING USING A FLUID-BED CATALYST - A method for preparation of ethylene and propylene by catalytic cracking using a fluid-bed catalyst. The main technical problems to be solved are a relatively high reaction temperature, and low activities and poor selectivities of the catalyst at a low temperature, during the reaction for preparing ethylene and propylene by catalytically cracking naphtha. The fluid-bed catalyst is a composition of the chemical formula Mo | 2009-05-28 |
| 20090137858 | SYSTEM AND METHOD FOR TREATING INFECTIOUS WASTE MATTER - A system and method is provided for producing a safely disposable end product from waste matter containing undesirable materials, such as infectious, biohazardous, hazardous, or radioactive elements. The method comprises the steps of providing a highly alkaline solvent, immersing the waste matter containing the undesirable materials within the highly alkaline solvent, and heating the solvent. The waste matter containing the undesirable materials is allowed to remain within the solvent until digested, thereby forming a solution void of any infectious or biohazardous elements and/or containing a decreased concentration of radioisotope. | 2009-05-28 |
| 20090137859 | PASSAGE EXPANSION DEVICE FOR PATIENTS - A method for opening a portion of a passageway of a patient is disclosed. The patient has a first metallic structure attached to a portion of the patient's neck. The method includes obtaining a second magnetic structure, placing the second magnetic structure proximate the first metallic structure attached to the portion of the patient's neck, and pulling the second magnetic structure away from the patient's neck to thereby open the passageway. | 2009-05-28 |
| 20090137860 | Biomedical Device for Treating by Virtual Immersion - The invention relates to a biomedical device comprising computing means, immersion means for dipping a patient in a virtual intelligent environment, an interface for controlling the computing means, operating the immersion means and for collecting results of related medical means and different means for obtaining said results. The inventive device is characterized in that the computing means are used for controlling the immersion means in such a way that virtual three-dimensional therapeutic environments comprising a virtual person in the form of the patient, a closed three-dimensional envelop emitting at a determined light frequency which envelops the person and any scenery in which the virtual person and the closed radiating envelop thereof are located for receiving a determined psycho-neuro-immunologic response, which is positive for the organism, are formed. In particular the inventive method consists in progressively increasing the light frequency of the closed envelop and of the person receiving said radiation. | 2009-05-28 |
| 20090137861 | APPARATUS AND METHOD FOR THE TREATMENT OF STRESS URINARY INCONTINENCE - An apparatus and method for the treatment of stress urinary incontinence. The apparatus includes a suburethral sling having an adjustment member for adjusting the tension of the sling both during the procedure and post-procedure. The method includes using a needle to simultaneously implant the sling and to deliver a local anesthetic in the groin area while implanting the sling. | 2009-05-28 |
| 20090137862 | ADJUSTABLE TISSUE SUPPORT MEMBER - The present disclosure relates to implants having two arms and a support portion configured to support a body tissue, such as a urethra. The implants are anchored in soft tissue with tissue anchors having a plurality of barbs. The tissue anchors contain an aperture through which a portion of arm is maintained. A locking member is disposed within at least one of the arms to facilitate fixation of the arm to at least one of the anchors. | 2009-05-28 |
| 20090137863 | Heart wall tension reduction apparatus - An apparatus for treatment of a failing heart by reducing the wall tension therein. In one embodiment, the apparatus includes a tension member for drawing at least two walls of a heart chamber toward each other. | 2009-05-28 |
| 20090137864 | Method and apparatus for treating pelvic organ prolapse - A method of treating pelvic organ prolapse is provided. The method generally includes the steps of establishing a first pathway between the external perirectal region of the patient to the region of the ischial spine in tissue on one side of the prolapsed organ, followed by establishing a second pathway in tissue on the contralateral side of the prolapsed organ. A support member, which includes a central support portion and two end portions, is positioned in a position to reposition said prolapsed organ in said organ's anatomically correct location. The end portions of the support member are introduced through the respective tissue pathways, followed by adjustment of the end portions so that the support member is located in a therapeutic relationship to the prolapsed organ that is to be supported. An apparatus and kit for said treatment is further provided. | 2009-05-28 |
| 20090137865 | Tissue Stabilizer and Methods of Use - Devices and methods are disclosed for stabilizing tissue within a patient's body during a surgical operation to provide a relatively motionless surgical field. The devices involve tissue stabilizers which provide superior engagement with a tissue structure to be stabilized, for example the beating heart. The tissue stabilizer may have one or more stabilizer feet which provide for adjustment of the orientation of the features which engage the surface of the tissue structure. In one instance, the orientation may be adjusted to ensure the engaging features will be properly aligned with the surface of the tissue structure before engagement. In addition, once engaged with or connected to the tissue structure the orientation may be adjusted to yield an optimum surgical presentation of a portion of the tissue structure, for instance a coronary artery or the like. The tissue stabilizer may be configured to use friction, negative pressure, or both to engage the surface of the heart. | 2009-05-28 |
| 20090137866 | Medical or veterinary digestive tract utilization systems and methods - Systems and methods are described for implementing or deploying medical or veterinary utility modules (a) operable for mooring at least partly within a digestive tract, (b) small enough to pass through the tract per vias naturales and including a wireless-control component, (c) having one or more attachment protrusions positionable adjacent to a mucous membrane, (d) configured to facilitate redundant modes of attachment, (e) facilitating a “primary” material supply deployable within a stomach for an extended and/or controllable period, (f) moored by one or more adaptable extender modules supported by a subject's head or neck, and/or (g) configured to facilitate supporting at least a sensor within a subject's body lumen for up to a day or more. | 2009-05-28 |
| 20090137867 | ENDOSCOPE TREATMENT SYSTEM - An endoscope treatment system includes: an endoscope; and a treatment tool that has a sheath that is inserted in a channel of an insertion portion of the endoscope, in which projection portions that project outward from the sheath in the radial direction are provided, and engagement portions that engage the projection portions are provided near the channel of the endoscope. | 2009-05-28 |
| 20090137868 | ENDOSCOPE SYSTEM - An endoscope system of the invention includes: a first endoscope capable of picking up an image of a subject; a first illuminating section capable of emitting first illuminating light; a second endoscope capable of picking up an image of the subject illuminated by the first light from a direction different from the first endoscope; a second illuminating section capable of emitting second illuminating light; a video signal processing section for generating a video signal based on a signal picked-up by the second endoscope; a display section for displaying an image of the subject obtained by the video signal processing section; an emphasis instructing section for instructing an emphasis on an image obtained based on the first light; and an emphasis control section for controlling to emphasize the subject image obtained based on the first light according to an operation of the emphasis instructing section. | 2009-05-28 |
| 20090137869 | SELF-ADVANCING DEVICE - A device which includes an elongate body with a movable mass arranged for sliding movement within the body is disclosed. The element is arranged to decelerate toward an end of the body in order to impart forward movement thereto, via momentum transfer, and is further arranged to accelerate away from said end in order to further drive the body forward, again using momentum transfer. | 2009-05-28 |
| 20090137870 | Transparent Dilator Device and Method of Use (END-900) - A medical device for use with an endoscope is provided. The medical device can include a tube with a first channel for receiving the endoscope. A transparent segment can extend from the distal end of the tube, and the transparent segment can have a first outer diameter sized for providing dilation of a portion of a body lumen. The medical device can also include a tapered tip attached to the distal end of the transparent segment that narrows from the first outer diameter to a distal terminating end. The endoscope is used to view the body lumen through the medical device while in use to dilate a stricture under direct visualization. | 2009-05-28 |
| 20090137871 | RADIO OBSERVATION DEVICE - A radio observation device which transmits information on observation subjects has a first coil, an oscillator, a first frequency controller, a frequency-measuring device, and a transmitter. The oscillator generates signals flowing through the first coil within a certain range of frequencies. The first frequency controller is connected to the oscillator, and adjusts the oscillating frequency of the signal flowing through the first coil by controlling said oscillator. The frequency-measuring device measures a resonance frequency of a signal flowing through the first coil and a signal flowing through a second coil being provided external to the radio observation device. The transmitter transmits the information on the observation subjects through said first coil by a carrier wave which oscillates at the resonance frequency. | 2009-05-28 |
| 20090137872 | Method and Apparatus for Controlling Endoscopic Instruments - An apparatus for the control of endoscopic instruments includes a control module mountable to a standard instrument port of an endoscope. The control module includes separate drive mechanisms for a sheath and a tensile cord of an endoscopic tool having an end effector. Driving the sheath and the tensile cord together may serve to advance or withdraw the end effector, driving either component separately may cause all activation of the end effector. | 2009-05-28 |
| 20090137873 | IN-VIVO INFORMATION ACQUIRING SYSTEM AND BODY-INSERTABLE APPARATUS - An in-vivo information acquiring system includes a body-insertable apparatus that transmits a wireless signal containing an in-vivo image, and a receiving apparatus that receives the wireless signal. The body-insertable apparatus includes an imaging unit, a selecting unit, and a transmitting unit. The imaging unit captures in-vivo images. The selecting unit selects an in-vivo image to be added with unique information from the in-vivo images. The transmitting unit additionally arranges an identification signal, which is written according to a signal sequence rule of synchronization signals added to scanning line information about the in-vivo image selected by the selecting unit, in a position corresponding to positions in which the synchronization signals are arranged, adds unique information corresponding to the identification information after the identification information, and transmits the in-vivo image added with the unique information. | 2009-05-28 |
| 20090137874 | Polymer Microvalve with actuators and devices - The present invention relates to a microvalve having a valve plug, connecting legs, anchors and actuators, allowing the valve plug to move vertically to open or close the valve. The valve plug can contain magnetic materials, and be operated by an actuator. | 2009-05-28 |
| 20090137875 | ENDOSCOPE INSERTION PORTION - An easy-to-manufacture endoscope is provided. | 2009-05-28 |
| 20090137876 | DIAGNOSTIC CAPSULE WITH PERIPHERAL IMAGING - A diagnostic capsule is disclosed having at least one light source; a rotatable substrate having at least one optical bench; at least one photo-sensitive region; and a circumferential window having an axis substantially parallel to an axis of rotation of the rotatable substrate. Related systems for use with a diagnostic capsule are also disclosed. An endoscopic diagnostic map is further disclosed. The endoscopic diagnostic map has a first dimension corresponding to a rotational position of at least one optical bench on a rotatable substrate of a diagnostic capsule. The endoscopic diagnostic map also has a second dimension corresponding a traveled position of the diagnostic capsule. Related methods of generating an endoscopic | 2009-05-28 |
| 20090137877 | TISSUE RETRACTORS - Methods and devices are provided for performing surgical procedures using tissue retractors. In general, a surgical retractor device is provided that includes a flexible fabric tissue retractor configured to support tissue. At least one grasping element can be coupled to a perimeter of the flexible fabric, and the grasping elements can be manipulated to couple the flexible fabric to a surgical port, e.g., a trocar, inserted through a body wall and extending into a body cavity. The grasping element can also be configured to move the flexible fabric and thereby move the tissue. | 2009-05-28 |
| 20090137878 | Flexible, Selectively Rotatable Tissue Retractor and Method for Using the Retractor - A retractor for manipulating an object, the retractor includes a retractor body with proximal and distal ends, a retraction device with a head connected at the distal end of the retractor body and flexible needles of a shape memory material having a memory shape, the memory shape of the needles including a portion with an arcuate shape housed, at least partially, within the head. The retractor further includes an actuation device connected to the proximal end of the retractor body and operatively connected to the needles, the actuation device, upon actuation thereof, moving the needles out of the head and withdrawing the needles into the head and a rotation joint allowing the distal end of the retractor body and the retraction device to rotate independent of the proximal end of the retractor body. | 2009-05-28 |
| 20090137879 | SURGICAL ACCESS APPARATUS AND METHOD - A surgical access device includes a single valve that forms a seal with the body wall and provides an access channel into a body cavity. The valve has properties for creating a zero seal in the absence of an instrument as well as an instrument seal with instruments having a full range of instrument diameter. The valve can include a gel and preferably an ultragel comprised of an elastomer and an oil providing elongation greater than 1000 percent and durometer less than 5 Shore A. The single valve can be used as a hand port where the instrument comprises the arm of a surgeon, thereby providing hand access into the cavity. | 2009-05-28 |
| 20090137880 | Determining the Risk of Breast Cancer for a Woman | 2009-05-28 |
