22nd week of 2009 patent applcation highlights part 39 |
Patent application number | Title | Published |
20090136986 | METHODS AND CELLS FOR CREATING FUNCTIONAL DIVERSITY AND USES THEREOF - The invention provides methods and compositions relating to cells having altered functions, and the nucleic acids that impart those functions. Altered cellular function arises from in vivo directed recombination of genetic elements to yield a recombined nucleic acid. These methods and compositions may utilize altered host cells having altered recombination enzyme profiles and/or altered recombination sites. The invention involves in some aspects methods for assembling nucleic acid molecules, such as genomic DNA. Aspects of the invention also provide kits, compositions, devices, and systems for generating novel recombined nucleic acids and cells having altered cell function. | 2009-05-28 |
20090136987 | Carbon Nanotube Based Imaging Agents - Compositions and methods related to carbon Nanotubes are provided. More particularly, imaging agents comprising carbon Nanotubes internally loaded with a contrast agent and associated methods are provided. One example of a method may involve a method for imaging comprising: providing an imaging agent comprising a carbon Nanotube loaded with contrast agent; introducing the imaging agent into a cell; and imaging the cell to detect the presence of the imaging agent. | 2009-05-28 |
20090136988 | METHOD AND DEVICE TO FRACTIONATE STEM CELLS - A method and the relevant instrumentation to fractionate living, adherent stem cells, particularly of human origin, from different sources is disclosed, said method is based on the non-equilibrium, dynamic fractionation of cells assisted by the Earth gravity field. | 2009-05-28 |
20090136989 | Method of Measuring the Activity of G(alpha)i-or G(alpha)o-Coupled Receptors Using Ca2+ Influx in Cells - A method of measuring the activation or deactivation of G(alpha)i- or G(alpha)o-coupled receptors, and methods of identifying agonists or antagonists of such receptors. | 2009-05-28 |
20090136990 | METHODS FOR IDENTIFYING SUBSTANCES FOR THE TREATMENT OF ALZHEIMER'S DISEASE - The present invention relates to a method for diagnosing Alzheimer's disease and Parkinson's disease in a subject by analyzing the expression of Semaphorin 3 and downstream effectors. It also provides a method for identifying a substance useful in the prevention or treatment of Alzheimer's disease and Parkinson's disease, and a method of using such substance in the treatment of Alzheimer's disease and Parkinson's disease. | 2009-05-28 |
20090136991 | Identifying Naive, Infected, or Vaccinated Mammals - This document provides methods and materials related to assessing a mammal's immunological state. For example, methods and materials related to assessing a mammal to determine whether the mammal is immunologically naïve with respect to a pathogen, was vaccinated against that pathogen, or is infected with that pathogen are provided. This document also provides methods and materials that can be used to determine whether or not a mammal (e.g., a cow) has an early stage infection (e.g., stage 1, Johne's disease). | 2009-05-28 |
20090136992 | SIMPLIFIED TISSUE PROCESSING - Improved systems and methods for tissue processing are described here. The chemical process and the construction of the apparatus are simplified by using only two different solutions in two separate reaction modules. They are compatible with processing of tissue specimens for genetic analysis, histology, in situ antibody binding and hybridization, archival preservation of morphology and nucleic acids, and combinations thereof. | 2009-05-28 |
20090136993 | Process for the Production of Gamma-Glutamylcysteine - The present invention relates to a process for preparing a compound comprising an α,γ amide linkage between a cysteine moiety and a glutamic acid moiety, such as γ-glutamylcysteine or a γ-glutamylcysteine derivative, the process comprising providing a cysteine derivative, a γ-glutamyl donor and an enzyme capable of transferring the γ-glutamyl group to said cysteine derivative in a reaction environment promoting transfer of the γ-glutamyl donor and cysteine derivative. The invention also relates to compounds comprising an α,γ amide linkage between a cysteine moiety and a glutamic acid moiety, such as γ-glutamylcysteine or a γ-glutamylcysteine derivative, when obtained by processes of the invention, and uses thereof. | 2009-05-28 |
20090136994 | Polypeptide having amidase activity and gene thereof - It is an object of the present invention to provide a novel amidase that is useful for production of an optically active amino acid, and in particular, a D-amino acid, and a production method thereof. | 2009-05-28 |
20090136995 | Mutated Prokaryotic Cells with High Secretion-Levels - A mutated prokaryotic cell, which secretes higher amounts of at least one heterologous polypeptide of interest and which has a reduced expression-level of YusZ or YusX, or homologues thereof, when compared with an otherwise isogenic but non-mutated cell, and methods for constructing and using such a cell in the production of polypeptides. | 2009-05-28 |
20090136996 | Novel cysteine-depleted hydrophobin fusion proteins, their production and use thereof - Polypeptides of the general structural formula (I) | 2009-05-28 |
20090136997 | PRO1550 POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME - The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. | 2009-05-28 |
20090136998 | LUCIFERASES AND METHODS FOR MAKING AND USING THE SAME - Briefly described, embodiments of this disclosure include polynucleotides that encode mutant | 2009-05-28 |
20090136999 | COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY OF CANCER AND INFECTIOUS DISEASES - The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided. | 2009-05-28 |
20090137000 | DNA POLYMERASES AND RELATED METHODS - Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 2009-05-28 |
20090137001 | PROCESS FOR PREPARING RECOMBINANT HUMAN THROMBIN WITH CULTURE CELL - The present invention provides for a process for preparing a recombinant human thrombin. A process for preparing a recombinant human thrombin which comprises: (1) obtaining a transfectant cell producing a human prothrombin by introducing an expression vector, wherein a gene fragment coding for a human prothrombin gene is incorporated, into an animal cell; (2) purifying a human prothrombin from the culture of the transfectant cell above by an anion exchanger; (3) converting the purified human prothrombin into a human thrombin by subjecting said human prothrombin to the action of ecarin; and (4) purifying the human thrombin from the solution after treatment with ecarin by an affinity method using benzamidine and a cation exchanger, and human thrombin obtained by said process, and a CHO cell that produces human prothrombin. | 2009-05-28 |
20090137002 | ANTI EPHB4 ANTIBODIES AND ANTIBODY FRAGMENTS - The invention concerns antibodies and antibody fragments, specifically recognising the EphB4 receptor comprising heavy chains and light chain, comprising light and heavy CDR's, and their use as medicament for the treatment of pathological angiogenesis, in particular cancer therapy. | 2009-05-28 |
20090137003 | Methods for recombinant manufacturing of anti-RSV antibodies - The invention relates to a method for manufacturing recombinant anti-RSV antibodies and antibody compositions. The method comprises obtaining a collection of cells transfected with a collection of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing one distinct anti-RSV antibody. The cells are cultured under suitable conditions for expression of the anti-RSV antibody/antibodies. The nucleic acid sequence is introduced into the cells by transfection with expression vectors, which avoid site-specific integration. The present method is suitable for manufacturing recombinant mono- and polyclonal anti-RSV antibodies for therapeutic uses. | 2009-05-28 |
20090137004 | ARTIFICIAL ENTROPIC BRISTLE DOMAIN SEQUENCES AND THEIR USE IN RECOMBINANT PROTEIN PRODUCTION - Compositions and methods for recombinant protein production and, more particularly, fusion polypeptides, polynucleotides encoding fusion polypeptides, expression vectors, kits, and related methods for recombinant protein production. | 2009-05-28 |
20090137005 | IL-12 for Expression in Mammalian Cell - The present invention provides for nucleic acids improved for the expression of interleukin-12 (IL-12) in mammalian cells. The invention further provides for methods of expressing IL-12 in mammalian cells by transfecting the cell with a nucleic acid sequence encoding an improved IL-12 sequence. | 2009-05-28 |
20090137006 | Sugar Kinases with Expanded Substrate Specificity and Their Use - One preferred embodiment of the present invention provides a GalK variant comprising a Y371H, M173L or Y371H-M173L mutation for in vivo and in vitro glycorandomization. In another preferred embodiment, the | 2009-05-28 |
20090137007 | Method for sequencing nucleic acid molecules - The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic acid polymerizing enzyme on the template nucleic acid molecule to be sequenced is followed in real time. The sequence is deduced by identifying which base is being incorporated into the growing complementary strand of the target nucleic acid by the catalytic activity of the nucleic acid polymerizing enzyme at each step in the sequence of base additions. A polymerase on the target nucleic acid molecule complex is provided in a position suitable to move along the target nucleic acid molecule and extend the oligonucleotide primer at an active site. A plurality of labelled types of nucleotide analogs are provided proximate to the active site, with each distinguishable type of nucleotide analog being complementary to a different nucleotide in the target nucleic acid sequence. The growing nucleic acid strand is extended by using the polymerase to add a nucleotide analog to the nucleic acid strand at the active site, where the nucleotide analog being added is complementary to the nucleotide of the target nucleic acid at the active site. The nucleotide analog added to the oligonucleotide primer as a result of the polymerizing step is identified. The steps of providing labelled nucleotide analogs, polymerizing the growing nucleic acid strand, and identifying the added nucleotide analog are repeated so that the nucleic acid strand is further extended and the sequence of the target nucleic acid is determined. | 2009-05-28 |
20090137008 | REDUCED INHIBITION OF ONE-STEP RT-PCR - The present invention provides a method for amplifying a nucleic acid molecule. The method involves mixing an RNA template with a composition having a reverse transcriptase, a DNA polymerase and a RT inhibition reducer. The RT inhibition reducer can be Sso7d, Sac7d, Sac7e, Sso7e, AluI methylase, suramin, a phosphorothioate oligodeoxycytosine, a phosphorothioate oligodeoxyadenine, a phosphorothioate oligodeoxythymine or poly(rA)(dT). The mixing forms a mixture that is incubated under conditions sufficient to synthesize a DNA molecule complementary to all or a portion of the RNA template, thereby amplifying the nucleic acid molecule. | 2009-05-28 |
20090137009 | METHOD FOR PRODUCING HYALURONIC ACID - The method for manufacturing hyaluronic acid rich matrix comprises the steps of providing a crest; and decellularizing a tissue of crest to form a decellularized hyaluronic acid rich matrix. | 2009-05-28 |
20090137010 | METHOD FOR PRODUCING AMINO ACIDS USING BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY - A method for producing an L-amino acid is described, for example, L-phenylalanine and L-histidine, by fermentation using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified by attaching a DNA fragment able to be transcribed encoding the peptide represented in SEQ ID NO: 2, or a variant thereof, particularly a portion of the ssrA gene, to the 3′-end of gene encoding for the bacterial enzyme, which influences on the L-amino acid biosynthesis, such as chorismate mutase/prephenate dehydrogenase or phosphoglucose isomerase. | 2009-05-28 |
20090137011 | METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE rcsA GENE - The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus | 2009-05-28 |
20090137012 | Process for producing lactonase and utilitzation thereof - It has been required to economically produce a large amount of optically active γ-lactone derivatives (for example, pantolactone), which are useful as intermediates in synthesizing useful substances such as pharmaceutical drugs. To achieve this object, it is advantageous to employ an enzymatic technique of asymmetric hydrolysis with a hydrolyzing enzyme lactonase. However, it remains troublesome to prepare the enzyme or utilize a microorganism capable of producing the enzyme. Also, it is difficult to obtain a sufficient and stable enzymatic activity in the case of using recombination techniques. In producing lactonase, which asymmetrically hydrolyzes a γ-lactone derivative such as racemic pantolactone selectively, by a recombination technique, both mature lactonase DNA and signal peptide region DNA are transferred into a host. Thus, a stable lactonase activity comparable to naturally-occurring one can be achieved and a transformant sustaining a high enzyme activity in a stable manner can be acquired, thereby allowing the efficient and industrially advantageous asymmetric synthesis of γ-lactone derivatives. | 2009-05-28 |
20090137013 | MICROORGANISMS AND METHODS FOR INCREASED HYDROGEN PRODUCTION USING DIVERSE CARBONACEOUS FEEDSTOCK AND HIGHLY ABSORPTIVE MATERIALS - The disclosed invention relates to an isolated hydrogen gas producing microorganism, termed | 2009-05-28 |
20090137014 | PRODUCTION OF ISOPRENOIDS - Provided herein are methods for a robust production of isoprenoids via one or more biosynthetic pathways. Also provided herein are nucleic acids, enzymes, expression vectors, and genetically modified host cells for carrying out the subject methods. Also provided herein are fermentation methods for high productivity of isoprenoids from genetically modified host cells. | 2009-05-28 |
20090137015 | METHOD AND APPARATUS FOR PREPARING MATERIAL FOR MICROBIOLOGICAL FERMENTATIONS - The present invention relates to a method for preparing organic material for microbiological fermentations of municipal waste water sludge for reducing the waste water sludge and/or of cellulosic material for the production of biofuels, with at least one of the following steps: disintegrating and/or liquefying the organic and/or cellulosic material by using a jet pump and/or creating a supersonic shock zone in a jet pump the organic and/or cellulosic material is supplied to in order to disintegrate and/or liquefy the organic and/or cellulosic material and/or applying high pressure steam to an annular ring chamber enclosing a tube of a jet pump and directing the steam into the tube of the jet pump thereby sucking organic and/or cellulosic material into the tube and creating a supersonic shock zone in the jet pump in order to disintegrate and/or liquefy the organic and/or cellulosic material. The present invention also relates to an apparatus for preparing organic material for microbiological fermentations of municipal waste water sludge for reducing the waste water sludge and/or of cellulosic material for production of biofuels comprising a jet pump. | 2009-05-28 |
20090137016 | Process for rapid anaerobic digestion of biomass using microbes and the production of biofuels therefrom - A process for effecting anaerobic digestion of plant biomass, which entails the step of anaerobically digesting plant biomass with at least one species of rumen microorganisms. | 2009-05-28 |
20090137017 | GENERATION AND ISOLATION OF ANTIGEN-SPECIFIC T CELLS - The present invention relates generally to methods for generating, expanding, and isolating antigen-specific T cells. Compositions of antigen-specific T cells activated and expanded by the methods herein are further provided. | 2009-05-28 |
20090137018 | MAGNETIC THREE-DIMENSIONAL CELL CULTURE APPARATUS AND METHOD - A culture apparatus and method for growing cells and tissue in a three-dimensional configuration harnesses magnetic, paramagnetic, ferromagnetic and diamagnetic forces. The cells or tissue are grown with magnetized core particles and are suspended via magnetic forces in a native, non-restricted, three-dimensional configuration while being maintained in a normal gravity (1 g) growth environment in the absence of rotational alteration of the gravity vector. | 2009-05-28 |
20090137019 | Thermostable luciferases and methods of production - Luciferase enzymes with greatly increased thermostability, e.g., at least half lives of 2 hours at 50° C., cDNAs encoding the novel luciferases, and hosts transformed to express the luciferases, are disclosed. Methods of producing the luciferases include recursive mutagenesis. The luciferases are used in conventional methods, some employing kits. | 2009-05-28 |
20090137020 | METHOD OF REVERSE TRANSCRIPTION - The present invention relates to reverse transcription of RNA, and in particular to reverse transcription by thermostable DNA polymerases. | 2009-05-28 |
20090137021 | Anti-inflammatory medicaments - Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compounds. | 2009-05-28 |
20090137022 | Extracting and purifying beta 1,4-xylanase - The invention relates to extracting and purifying an enzyme from a cell, particularly, but not exclusively, to extracting and purifying a β1,4-xylanase. | 2009-05-28 |
20090137023 | Cytoplasm of Eukaryotic cells for reprogramming of somatic cells, healing, repairing and therapeutic applications - The present invention relates to a method for cellular reprogramming, healing and repairing for therapeutic applications by removal of the cytoplasm from the cell, collecting the cytoplasm together to form a bath of cytoplasm and then immersing one or more somatic cells into the cytoplasm bath. Alternatively, the collection of cytoplasm can be injected or mixed in with a collection of somatic cells. This is dramatically different form all other approaches were transfer of cytoplasm and/or nucleus is performed by injection from one cell directly into another cell through varies methods. This method of immersing mammalian cells into a cytoplasm environment in particular a plutipotent stem cell cytoplasm environment has many potential uses. | 2009-05-28 |
20090137024 | Method of Separating Target DNA from Mixed DNA - The present invention relates to methods of separating target DNA from mixed DNA in a sample. In some embodiments, the target DNA may be viral DNA, bacterial DNA, fungal DNA or combinations thereof. In some embodiments the mixed DNA includes target DNA and non-target DNA. | 2009-05-28 |
20090137025 | Apparatus for containing, cultivating, and harvesting photosynthetic marine microorganisms within water - An apparatus contains photosynthetic marine microorganisms within water, to permit the marine microorganisms to be cultivated and harvested. A self-supporting buoyant frame of the apparatus is to be placed within the water. A mesh lining of the apparatus is situated within the interior of the frame. The mesh lining is adapted to permit the water and nutrients to enter through the mesh lining while at least substantially preventing the marine microorganisms that are being cultivated from escaping through the mesh lining. A funnel of the apparatus is attached to a corresponding hole at a bottom of the mesh lining, and is adapted to permit the marine microorganisms that have been cultivated to be harvested. A buoyancy leveling subsystem of the apparatus is adapted to control an extent to which the frame is submerged within the water. | 2009-05-28 |
20090137026 | Cell culture device - In a cell culture device, a fluid mechanism for branching a liquid appropriately in its flow passage when the liquid is injected to a plurality of culture vessels in a set and feeding equal amounts of the culture broth to the culture vessels at the same time is provided. | 2009-05-28 |
20090137027 | SOLID PHASE METHODS FOR POLYNUCLEOTIDE PRODUCTION - Polynucleotides having in excess of 1,000 nucleotides can be prepared using a solid phase synthesis technique. A feature of the technique is the use of a reusable solid support that contains covalently bound oligonucleotide. This covalently bound oligonucleotide is annealed to a bridge oligonucleotide, where the bridge is also annealed to a first oligonucleotide that forms a portion of the target polynucleotide. After the target polynucleotide is synthesized, it can be removed from the solid support under denaturing conditions, and the solid support re-used to prepare additional target polynucleotides. The yield of the target polynucleotide increases when shearing force is applied to the solid support that is linked to the growing oligonucleotide. This shearing force is thought to extend the growing end of the oligonucleotide away from contact with other oligonucleotide bound to the solid support and make that end more accessible to annealing with solution oligonucleotide. The synthesis is conveniently accomplished on a porous frit, where reagents and washing solutions are pumped through the frit. | 2009-05-28 |
20090137028 | EMBEDDED BLOCK HUMIDIFIER, AUTOMATIC THIN SLICE MANUFACTURING DEVICE, AND AUTOMATIC THIN SLICE SPECIMEN MANUFACTURING APPARATUS - An embedded block is capable of being humidified in a short time without influencing a surface temperature of the embedded block as much as possible. An embedded block humidifier for humidifying an embedded block having a biological specimen embedded in an embedding agent is provided which includes a vapor generating mechanism for generating vapor heated at a predetermined temperature and a guiding mechanism for guiding the vapor to the embedded block so that the generated vapor contacts with a surface of the embedded block set at a predetermined standby position. | 2009-05-28 |
20090137029 | Multi-Chambered Receptacles - A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle. | 2009-05-28 |
20090137030 | Incubator, schedule management method, and program - An input section of an incubator accepts, from a user, a first input selecting a specified incubation container which registers an observing schedule, and a second input specifying an imaging condition of the specified incubation container in an observing sequence. A calculating section calculates, according to the above-mentioned imaging condition, an observing duration of the specified incubation container from a first data relating to a carrying period of an incubation container and a second data with regard to an imaging duration. A schedule management section extracts, based on a schedule data, a registrable time zone in which an observing sequence of the specified incubation container can be executed without overlapping with previously registered observing schedules, and outputs to display the registrable time zone for presentation to the user. | 2009-05-28 |
20090137031 | Culturing Apparatus and Culturing Method for Photosynthesis Microorganism - A culturing apparatus for photosynthesis microorganism provided by the present invention comprises a outer vessel, inner vessel, culture solution circulating portion and a heat transfer medium feeding portion. Culture solution containing photosynthesis microorganism is put into the outer vessel which is transparent and configured like a cylinder extending in a predetermined axis-direction. The inner vessel is disposed in the outer vessel, being configured like a cylinder extending in the above axis-direction. The culture solution circulating portion draws culture solution from one side along the axis-direction in the outer vessel, supplying that to the other side of the axis-direction. The heat transfer medium feeding portion supplies heat transfer medium into the inner vessel. | 2009-05-28 |
20090137032 | Cell- and Tissue Culture Device - The present invention relates to the field of cell and tissue culture. In particular, the invention provides a novel device for organotypic culture. The device comprises a medium conduit having one open end and one end closed by a porous membrane fused across it; and a frame holding the medium conduit in a substantially vertical orientation; wherein the medium conduit is adapted to permit retention by capillarity of a sufficient volume of liquid culture medium in the medium conduit to contact the surface of the porous membrane and thus supply nutrients to cells that may be grown on the porous membrane. The device may further comprise a cell suspension conduit having one end open and one end closed by the surface of said porous membrane contralateral to the surface of said porous membrane sealed to said medium conduit; wherein said frame holds the medium conduit and the cell suspension conduit in a substantially vertical orientation. | 2009-05-28 |
20090137033 | NOVEL FLUORESCENT PROTEINS FROM AEQUOREA COERULSCENS AND METHODS FOR USING SAME - The present invention provides nucleic acid compositions encoding a novel colorless GFP-like protein, acGFP, from | 2009-05-28 |
20090137034 | METHODS FOR PERFUSION AND PLATING OF PRIMARY HEPATOCYTES AND A MEDIUM THEREFORE - The present invention provides methods for culturing primary hepatocytes with improved long term function and improved viability, by plating the hepatocytes in the presence of an anti-oxidant(s) as well as an agent(s) which is a functional inhibitor of enzymes that generate reactive oxygen and reactive nitrogen species. One preferred embodiment provides a combination of 2-oxo-thizolidine and tocopherol succinate. Another preferred embodiment provides a combination of N | 2009-05-28 |
20090137035 | TWEAK RECEPTOR - The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue. | 2009-05-28 |
20090137036 | TWEAK RECEPTOR - The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue. | 2009-05-28 |
20090137037 | NUCLEIC ACIDS CODING FOR HUMANIZED ANTIBODIES FOR BINDING SPHINGOSINE-1-PHOSPHATE - The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P. | 2009-05-28 |
20090137038 | METHODS OF PROLIFERATING STEM CELLS - The invention relates to methods of proliferating stem cells. More particularly, the invention relates to the use of glycosaminoglycans or proteoglycans to promote the growth of stem cells in ex vivo culture, while preserving their multipotentiality. | 2009-05-28 |
20090137039 | TARGETING OPPOSITE STRAND REPLICATION INTERMEDIATES OF SINGLE-STRANDED VIRUSES BY RNAI - The invention relates to methods and compositions for modulating viral replication through double-stranded RNA-mediated gene silencing (RNAi), wherein the antiviral methods and compositions preferentially target opposite strand replication intermediates of single-stranded RNA viruses. | 2009-05-28 |
20090137040 | METHODS FOR MAKING AND USING REPROGRAMMED HUMAN SOMATIC CELL NUCLEI AND AUTOLOGOUS AND ISOGENIC HUMAN STEM CELLS - Activated human embryos produced by therapeutic cloning can give rise to human totipotent and pluripotent stem cells from which autologous cells for transplantation therapy are derived. The present invention provides methods for producing activated human embryos that can be used to generate totipotent and pluripotent stem cells from which autologous cells and tissues suitable for transplantation can be derived. In one embodiment, the invention provides methods for producing activated human embryos by parthenogenesis; in another embodiment, the invention provides methods for producing activated human embryos by somatic cell nuclear transfer whereby the genetic material of a differentiated human donor cell is reprogrammed to form a diploid human pronucleus capable of directing a cell to generate the stem cells from which autologous, isogenic cells for transplantation therapy are derived. The ability to create autologous human embryos represents a critical step towards generating immune-compatible stem cells that can be used to overcome the problem of immune rejection in regenerative medicine. The activated human embryos produced by the present invention also provide model systems for identifying and analyzing the molecular mechanisms of epigenetic imprinting and the genetic regulation of embryogenesis and development. | 2009-05-28 |
20090137041 | 3-HYDROXYISOTHIAZOLE-4-CARBOXAMIDINE DERIVATIVES AS CHK2 INHIBITORS - This invention provides compounds of Formula I | 2009-05-28 |
20090137042 | PROCESSES AND SYSTEMS FOR HYDRATING AND SEEDING MEDICAL IMPLANTS WITH BIOLOGICAL COMPONENTS - Methods and systems for providing an improved apparatus and packaging system to more expeditiously hydrate or reconstitute medical grafts and to effectively and uniformly seed the medical grafts with biological components and cultured cells. The systems generally comprise a container comprising entry port, at least one substrate cavity, and top, side and bottom walls defining an inner surface. The entry port is configured to receive the biological solution. The cavity is in communication with the entry port and includes the porous substrate maintained under negative pressure. The container volume is substantially the same as a volume of the porous substrate. The side and bottom walls are configured to promote a laminar flow of the biological solution received through the entry port. | 2009-05-28 |
20090137043 | METHODS FOR MODIFICATION OF POLYMERS, FIBERS AND TEXTILE MEDIA - The present subject matter relates to the modification of fibers by the growth of films by the Atomic Layer Epitaxy (ALE) process, which is also commonly referred to as Atomic Layer Deposition (ALD). The presently disclosed subject matter relates in particular to a process for the modification of the surface and bulk properties of fiber and textile media, including synthetic polymeric and natural fibers and yarns in woven, knit, and nonwoven form by low-temperature ALD. | 2009-05-28 |
20090137044 | SCHISTOSE MICROFIBRILLATED ARTICLE FOR CELL GROWTH - The present invention relates to culturing cells utilizing a matrix of microfibrillated thermoplastic polymeric materials. More specifically, the present invention relates to a method of culturing cells. In addition, the invention relates to a biaxially oriented microfibrillated article for culturing cells dispersed in a cell culture medium. The matrix of thermoplastic polymeric materials for culturing cells of this invention finds use in tissue engineering and wound healing applications. | 2009-05-28 |
20090137045 | Pyridinium Cationic Lipids as Gene Transfer Agents - Pyridinium cationic lipids useful as non-viral gene delivery agents are disclosed. The agents are prepared by reaction of pyrylium salts with primary amines. Also disclosed are methods of trasfectind cells using the pyridinium cationic lipids as gene transfer agents. | 2009-05-28 |
20090137046 | Splicing-Mediated Regulation Of Gene Expression - The present invention relates to methods and compositions for controlling the expression of a target gene, whereby an intron cassette such as INT9, an intronic mec-2-derived element, is incorporated into the target gene and expression of the product of the target gene is conditional upon functional expression of the RNA processing protein, mec-8. | 2009-05-28 |
20090137047 | Automated Diagnostic Kiosk for Diagnosing Diseases - An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes. | 2009-05-28 |
20090137048 | AUTOMATIC ANALYZER AND ANALYSIS METHOD FOR USE IN THE SAME - An automatic analyzer having a high processing capability even when plural kinds of reagents are dispensed at different timings. The automatic analyzer comprises a plurality of reaction cells, a reaction cell moving unit for moving the plurality of reaction cells at a certain cycle; a sample dispensing unit for dispensing a sample into a reaction cell on the reaction cell moving unit, a reagent dispensing unit for dispensing plural kinds of reagents to be added during a sample—reagent reaction process at different timings, the number of the reagent addition timings being larger than the number of times at which the reagents can be dispensed within a time of one cycle, and a control unit for controlling the sample dispensing unit to set a cycle in which no sample is dispensed by the sample dispensing unit, when analyses each using the reagent to be dispensed at the latest one of the reagent addition timings by the reagent dispensing unit succeed a predetermined number of times or more. | 2009-05-28 |
20090137049 | METHOD FOR THE PRESUMPTIVE DETECTION OF SUBSTANCES - A composition for use in the detection of an intoxicating drug comprising: (i) a first compound that absorbs UV radiation and generates emitted UV radiation at a wavelength absorbable by said intoxicating drug; and (ii) a second compound that absorbs UV radiation emitted by said intoxicating drug upon absorption by said intoxicating drug of said emitted UV radiation and that emits radiation in the visible spectrum is provided. In addition, methods for detecting an intoxicating drug in a sample comprising irradiating with UV radiation a sample contacted with one or two compounds that absorb UV radiation are provided. | 2009-05-28 |
20090137050 | Artificial protein, method for absolute quantification of proteins and uses thereof - The invention provides an artificial protein for quantitative analysis of the proteome of a sample, cell or organism, comprising at least two consecutive peptides linked by a cleavage sequence for separating the peptides; a singular marker on one or more peptide for determination of the absolute amount of this fragment; and N-terminal and C-terminal extensions for protection of the peptides; wherein each peptide represents one single protein of the sample, cell or organism and each peptide is in a defined stoichiometry. The invention further provides a collection of peptides, a vector and a kit comprising the artificial protein and a method for quantitative analysis of the proteome. | 2009-05-28 |
20090137051 | Monoclonal Antibodies Directed Against The Microtubule-Associated Protein Tau - A monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to human abnormally phosphorylated tau proteine. The tau protein can be obtained from a brain homogenate, itself isolated from the cerebral cortex of a patient having Alzheimer's disease. | 2009-05-28 |
20090137052 | PHOSPHOPEPTIDE ANALYSIS METHOD - According to the present invention, a matrix reagent prepared by adding methylenediphosphonic acid (MDPNA) having two phosphonic acid groups as an additive to a matrix of 2,5-dihydroxybenzoic acid (DHBA) is used for the preparation of a sample. By using the sample according to the present invention, it is possible to achieve a higher peak intensity of phosphopeptide as compared with a sample in which DHBA is solely used as a matrix without using an additive, or a sample in which phosphoric acid (PA) is used as an additive in addition to DHBA. Further, use of the sample according to the present invention enables the detection of peptides that cannot be detected in a case of the phosphoric acid-added sample. | 2009-05-28 |
20090137053 | BEAD SET, PRODUCTION PROCESS OF THE BEAD SET, AND METHOD OF USING THE BEAD SET - A bead set is composed of plural subsets of beads. The beads in each subset are each provided with a surface permitting immobilization thereon of a substance that takes part in a predetermined corresponding reaction or interaction. The individual beads in the beat set are provided with different physical elements, respectively, such that the individual beads in the bead can be distinguished into the plural subsets through an analysis of captured images of the individual beads in the bead set by a computer. | 2009-05-28 |
20090137054 | HYDROGEN SULFIDE INDICATING PIGMENTS - Disclosed is a pigment that changes color upon exposure to hydrogen sulfide gas. The pigment may be ground or otherwise reduced to small particles and used in coatings, dyes, paints or inks. Potential applications for paints and inks include the production of warning indicators for the presence of hydrogen gas in areas where such presence may pose a hazard. Warning decals may be printed with pigmented ink and posted in areas of potential hydrogen hazard. In the presence of hydrogen sulfide gas, the decals can display a warning by causing a change in the color of a printed message. Objects may also be coated with pigmented paints so that if a hydrogen sulfide leak occurs from within or nearby the object, the color of the object changes to provide a warning of the presence of leaked hydrogen sulfide. Example applications of such painted objects include any industrial process containing hydrogen sulfide. | 2009-05-28 |
20090137055 | MEASURING NITROGEN OXIDES AND OTHER GASES BY OZONE FORMATION - A photochemical sensing system enables the measurement of nitrogen oxides (nitrogen dioxide and nitric oxide) by photolyzing nitrogen dioxide to form oxygen atoms which combine with oxygen molecules to form ozone. Ozone reacts with nitric oxide to for nitrogen dioxide-decreasing ozone. Changes in ozone concentration are measured as a surrogate for the nitrogen dioxide and nitric oxide. Any species which photolyzes to yield oxygen atoms may be measured by this technique. Additional specificity for nitrogen oxides is conferred by allowing the nitric oxide to react with the ozone to recreate the nitrogen dioxide. By periodically photolyzing the nitrogen dioxide (to form ozone), and then allowing the resulting nitric oxide to react with the ozone (thereby reducing ozone), a pulsed signal is obtained whose amplitude is proportional to the total amount of nitrogen dioxide and nitric oxide present. Medical applications include measuring nitric oxide concentrations in expired air samples. | 2009-05-28 |
20090137056 | METHODS FOR DETECTING DIHYDROXYVITAMIN D METABOLITES BY MASS SPECTROMETRY - Provided are methods of detecting the presence or amount of a dihydroxyvitamin in D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay. | 2009-05-28 |
20090137057 | LUMINESCENT DIKETONATE POLYMERS - The present invention provides in one aspect polymeric luminescent dye compounds having fluorescent properties, phosphorescent properties, or both fluorescent and phosphorescent properties. | 2009-05-28 |
20090137058 | CHEMICAL AND BIOLOGICAL DETECTION METHOD AND DEVICE BASED ON MEASUREMENTS OF FLUORESCENCE AND REFLECTIVITY - A device and method for detecting the presence of one or more analytes, bound directly or indirectly to a binding substrate functionalized with a fluorophore, based on measurements of fluorescence and reflectivity. The device and methods comprise an excitation source that emits light capable of being absorbed by a fluorophore and results in the fluorophore's excitation and emission, a fluorescent probe specific for the analyte that is attached via chemisorption to the binding substrate, a detector, and a processor adapted to determine the quantity of the one or more analytes present, by correlating measurements of reflected and fluorescent light. | 2009-05-28 |
20090137059 | Inorganic Polymers and Use of Inorganic Polymers for Detecting Nitroaromatic Compounds - A method for detecting an analyze that may be present in ambient air, bound to a surface or as part of complex aqueous media that includes providing a metallole-containing polymer or copolymer, exposing the polymer or copolymer to a suspected analyze or a system suspected of including the analyze, and measuring a quenching of photoluminescence of the metallole-containing polymer or copolymer exposed to the system. Also included is a solid state inorganic-organic polymer sensor for detecting nitroaromatic compounds that includes a substrate and a thin film of a metallole-containing polymer or copolymer deposited on said substrate. | 2009-05-28 |
20090137060 | MULTICOLORED PARTICLES - A set of polymer particles stained with at least two fluorescent dyes is presented. At least 16 subsets of particles can be resolved on the basis of variable emission from the at least two fluorescent dyes where emission from at least one dye derives from a fluorescent dye covalently attached to the particle surface. All particles in the set of polymer particles can bind a uniform amount of a capture reagent. A method for the preparation of the set of polymer particles as well as a kit including the set of polymer particles is also presented as well as methods and uses of the set of polymer particles. | 2009-05-28 |
20090137061 | DETECTING MOLECULES - The invention relates to separating molecules, in particular, to proteins comprised in biological fluid such as serum, to purifying molecules and to producing antisera to molecules. | 2009-05-28 |
20090137062 | ANALYSIS SYSTEM AND METHOD FOR THE ANALYSIS OF A BODY FLUID SAMPLE FOR AN ANALYTE CONTAINED THEREIN - Analysis system and method for the analysis of a body fluid sample for an analyte contained therein are disclosed. The analysis system has a dosing station for dosing a liquid into a test element through a sample supply opening, which reacts with a reagent system present in a sample analysis channel of the test element. The analysis system also has a measurement station for measuring a measurement variable characteristic of the reaction at the measuring zone of a test element for the analytical result. The test element also includes a separate flushing liquid supply opening and a flushing liquid collection chamber which are in fluid communication to one another via a flushing liquid channel. The flushing liquid channel and the sample analysis channel differ from one another in such a manner that a liquid flowing through the flushing liquid channel does not reach the measuring zone. | 2009-05-28 |
20090137063 | METHOD FOR DETERMINING THE QUALITY OF A BIOLOGICAL SAMPLE - The present invention relates to a method of determining the quality of a biological sample. A method according to the invention may be used to determine if a biological sample is suitable to use in a further biological assay demanding samples of good quality to render an accurate result. The method comprises detecting the presence of protein fragments in the biological sample by using appropriate means. The invention also relates to a kit for determining the quality of a biological sample. | 2009-05-28 |
20090137064 | LIGAND MOLECULE-IMMOBILIZED POLYMER, LIGAND MOLECULE-IMMOBILIZED PARTICLE, METHOD OF DETECTING TARGET SUBSTANCE, AND METHOD OF SEPARATING TARGET SUBSTANCE - A ligand molecule-immobilized polymer has a structure represented by the following general formula (1). | 2009-05-28 |
20090137065 | METHOD FOR MANUFACTURING MEMORY DEVICE - A method for manufacturing a memory device including a ferroelectric memory array region and a logic circuit region is provided. The method includes the steps of: forming, above a base substrate, a plurality of ferroelectric capacitors in the ferroelectric memory array region; forming a wiring layer above the base substrate in the logic circuit region; forming an interlayer dielectric layer that covers the ferroelectric capacitors and the wiring layer; etching the interlayer dielectric layer formed at least in the ferroelectric memory array region to form a concave section; polishing the interlayer dielectric layer by a CMP (chemical mechanical polishing) method; etching the interlayer dielectric layer above the ferroelectric capacitors and the wiring layer to form contact holes; and forming contact sections in the contact holes. | 2009-05-28 |
20090137066 | Sensor for a magnetic memory device and method of manufacturing the same - The invention encompasses fabrication methods including the steps of preparing a silicon substrate, forming an amorphous III-V material layer on the silicon substrate, heating the amorphous III-V material layer, and epitaxially growing III-V material on the amorphous III-V material layer. | 2009-05-28 |
20090137067 | METHOD FOR FORMING AN INDUCTOR - A spiral inductor fabricated above a semiconductor substrate provides a large inductance while occupying only a small surface area. Including a layer of magnetic material above and below the inductor increases the inductance of the inductor. The magnetic material also acts as barrier that confines electronic noise generated in the spiral inductor to the area occupied by the spiral inductor. Inductance in a pair of stacked spiral inductors is increased by including a layer of magnetic material between the stacked spiral inductors. | 2009-05-28 |
20090137068 | Method and Computer Program Product for Wafer Manufacturing Process Abnormalities Detection - A method for wafer manufacturing process abnormalities detection, the method includes: generating a classifier in response to compression based similarities between relevant wafer manufacturing process information of pairs of wafers; and utilizing the classifier to detect wafer manufacturing process abnormalities. | 2009-05-28 |
20090137069 | Chip packaging process including simpification and mergence of burn-in test and high temperature test - A chip packaging process integrates a burn-in test or a high temperature test to simplify overall packaging and testing process flow. One or more chips are disposed on one or more units of a substrate strip where the substrate strip has a plurality of electrical open sections at the plating lines to electrically isolate the external pads between different units. After electrical connection and encapsulation, a burn-in test is executed at the same time of a post mold curing step, with a high-temperature testing if necessary. Therefore, the chips on the substrate strip has been gone through the burn-in test during the encapsulant is completely cured at the post mold curing step and the burn-in test is finished before the singulation step to reduce the overall testing time. | 2009-05-28 |
20090137070 | Manufacturing Method for Partially-Good Memory Modules with Defect Table in EEPROM - A manufacturing method makes memory modules from partially-good DRAM chips soldered to its substrate. The partially-good DRAM chips have a number of defective memory cells that is below a test threshold, such as 10%. Packaged DRAM chips are optionally pre-screened and considered to pass when the number of defects found is less than the test threshold. A defect table is created during testing and written to a serial-presence-detect electrically-erasable read-only memory (SPD-EEPROM) on the memory module. The memory module is finally tested on a target-system tester that reads the defect table during booting, and redirects memory access to defective memory locations identified by the defect table. The memory modules may be burned in or tested at various temperatures and voltages to increase reliability. | 2009-05-28 |
20090137071 | High Reliability Surveillance and/or Identification Tag/Devices and Methods of Making and Using the Same - The present invention relates to methods of making capacitors for use in surveillance/identification tags or devices, and methods of using such surveillance/identification devices. The capacitors manufactured according to the methods of the present invention and used in the surveillance/identification devices described herein comprise printed conductive and dielectric layers. The methods and devices of the present invention improve the manufacturing tolerances associated with conventional metal-plastic-metal capacitor, as well as the deactivation reliability of the capacitor used in a surveillance/identification tag or device. | 2009-05-28 |
20090137072 | LIGHT EMITTING DEVICE METHODS - Light-emitting device methods are disclosed. | 2009-05-28 |
20090137073 | LIGHT EMITTING DIODE PACKAGE AND FABRICATION METHOD THEREOF - The present invention provides an LED package and the fabrication method thereof. The present invention provides an LED package including a submount silicon substrate and insulating film and electrode patterns formed on the submount silicon substrate. The LED package also includes a spacer having a through hole, formed on the electrode patterns. The LED package further includes an LED received in the through hole, flip-chip bonded to the electrode patterns, and an optical element attached to the upper surface of the spacer. | 2009-05-28 |
20090137074 | Method of manufacturing display device - A method of manufacturing a display device includes: preparing a substrate including a first area and a second area, forming a first layer on the first area and the second area, forming a second layer on the first layer of the first area, respectively forming a first electrode layer on the second layer of the first area and the first layer of the second area, forming a reflective layer on the first electrode layer of the first area, and forming a second electrode layer on the reflective layer. | 2009-05-28 |
20090137075 | Method of manufacturing vertical light emitting diode - Provided is a method of manufacturing a vertical LED, the method including the steps of: preparing a sapphire substrate; forming a light emitting structure in which an n-type nitride semiconductor layer, an active layer, and a p-type nitride semiconductor layer are sequentially laminated on the sapphire substrate; forming a p-electrode on the p-type nitride semiconductor layer; forming a structure support layer on the p-electrode; removing the sapphire substrate through an LLO (laser lift-off) process; isolating the light emitting structure into unit LED elements through an ISO (isolation) process; and forming an n-electrode on each of the n-type nitride semiconductor layers of the isolated light emitting structures. | 2009-05-28 |
20090137076 | SURFACE EMITTING SEMICONDUCTOR LASER, ITS MANUFACTURING METHOD, AND MANUFACTURING METHOD OF ELECTRON DEVICE - A surface emitting semiconductor laser which can perform laser oscillation in a single peak beam like that in a single lateral mode and a manufacturing method which can easily manufacture such a laser at a high yield are provided. When a surface emitting semiconductor laser having a post type mesa structure is formed on an n-type semiconductor substrate, a mesa portion is formed and up to a p-side electrode and an n-side electrode are formed. Thereafter, a voltage is applied across the p-side and n-side electrodes and the laser is subjected to a steam atmosphere while extracting output light, thereby forming an Al oxide layer onto a p-type Al | 2009-05-28 |
20090137077 | Thin film transistor array substrate and fabricating method thereof - A liquid crystal display and a fabricating method thereof for improving an aperture ratio are disclosed. A liquid crystal display (LCD) according to the present invention includes a gate line, a data line and a common line on the thin film transistor array substrate, the gate line crossing the data line to define a pixel region; a thin film transistor near the crossing of the gate line and the data line; a common electrode connected to the common line in the pixel region; and a pixel electrode connected to the thin film transistor in the pixel area for forming an in-plane electric field in association with the common electrode during an operation of the LCD, wherein an edge of the pixel electrode overlaps the common line with at least one insulating layer therebetween, and an edge of the common electrode overlaps the pixel electrode with said at least one insulating layer therebetween. | 2009-05-28 |
20090137078 | Semiconductro laser device - This semiconductor laser device has the same structure as the conventional broad-area type semiconductor laser device, except that both side regions of light emission areas of active and clad layers are two-dimensional-photonic-crystallized. The two-dimensional photonic crystal formed on both side regions of the light emission area is the crystal having the property that 780 nm laser light cannot be wave-guided in a resonator direction parallel to a striped ridge within the region. The light traveling in the direction can exist only in the light emission area sandwiched between two photonic crystal regions, which results in the light laterally confined by the photonic crystal region. The optical confinement of the region suppresses the loss in the light at both edges of the stripe serving as the boundary of the optical confinement, which reduces the curve of wave surface and uniforms the light intensity distributions of NFP and FFP. | 2009-05-28 |
20090137079 | Method for manufacturing a microelectromechanical component, and a microelectromechanical component - The invention relates to microelectromechanical components, like microelectromechanical gauges used in measuring e.g. acceleration, angular acceleration, angular velocity, or other physical quantities. The microelectromechanical component, according to the invention, comprises a microelectromechanical chip part, sealed by means of a cover part, and an electronic circuit part, suitably bonded to each other. The aim of the invention is to provide an improved method of manufacturing a microelectromechanical component, and to provide a microelectromechanical component, which is applicable for use particularly in small microelectromechanical sensor solutions. | 2009-05-28 |
20090137080 | PHASE CHANGE MEMORY DEVICE AND METHOD FOR MANUFACTURING THE SAME - A phase change memory device reduces the current necessary to cause a phase change of a phase change layer. The phase change memory device includes a first oxide layer formed on a semiconductor substrate; a lower electrode formed inside the first oxide layer; a second oxide layer formed on the first oxide layer including the lower electrode, the second oxide having a hole for exposing a part of the lower electrode; a phase change layer formed on a surface of the hole with a uniform thickness so as to make contact with the lower electrode; and an upper electrode formed in the hole and on a part of the second oxide layer, the part being adjacent to the hole. | 2009-05-28 |
20090137081 | PHASE CHANGE RAM DEVICE AND METHOD FOR MANUFACTURING THE SAME - A phase change RAM device includes a semiconductor substrate having a phase change cell area and a voltage application area; a first oxide layer, a nitride layer and a second oxide layer sequentially formed on the semiconductor substrate; a first plug formed in the first oxide layer, the nitride layer and the second oxide layer of the phase change cell area; a second plug formed in the first oxide layer and the nitride layer of the voltage application area; a conductive line formed in the second oxide layer; a third oxide layer formed on the second oxide layer; a lower electrode shaped like a plug, the lower electrode being formed so as to directly make contact with the first plug; and a phase change layer and an upper electrode sequentially formed on the lower electrode in a pattern form. | 2009-05-28 |
20090137082 | Manufacturing method for electronic devices - A manufacturing method for manufacturing an electronic device includes a first electronic component and a second electronic component; and a bond part for the first electronic component joined to another bond part for the second electronic component. In a first process of this manufacturing method, the metallic bond part for the first electronic component is placed directly against the metallic bond part for the second electronic component, pressure is applied to the first electronic component and the second electronic component and, after metallically joining the above two bond parts, the pressure applied to the first electronic component and the second electronic component is released. In a second process in the manufacturing method, a clamping member affixes the relative positions of the joined first electronic component and second electronic component, and heats the first electronic component and the second electronic component to maintain a specified temperature. | 2009-05-28 |
20090137083 | ASSEMBLING OF DOUBLED-SIDE STACKING PULRAL CHIPS - Disclosed is a method for assembling a semiconductor device, especially to dispose a plurality of chips on double sides of a chip carrier, such as a lead frame. At least a first chip is disposed on one surface of the chip carrier. Then, a protecting spacer is disposed on the active surface of the first chip. Then, the chip carrier is flipped over and placed on a hot plate where the protecting spacer keeps the active surface of the first chip away from direct contact with the hot plate. After the flipping and placing step, at least a second chip is disposed on another surface of the chip carrier and then is electrically connected to the chip carrier by a plurality of bonding wires. Therefore, any damages to the active surface of the first chip are avoided during disposition and electrical connections of the second chip. | 2009-05-28 |
20090137084 | Method and apparatus for manufacturing semiconductor module - Disclosed herewith is a semiconductor module manufacturing apparatus capable of reducing occurrence of warping of the wiring substrate, etc., as well as occurrence of failures of bonding between the wiring substrate and semiconductor chips, etc. without lowering the productivity. The semiconductor module manufacturing apparatus employs a batch reflowing process that heats one, two, or more wiring substrates and at least two or more semiconductor chips or semiconductor devices simultaneously. After the heating process, the semiconductor chips or semiconductor devices are heated and bonded on the wiring substrate. The apparatus includes at least a stage for chucking the wiring substrate fixedly; a heat source for heating the semiconductor chips or semiconductor devices out of contact therewith; and a controller for controlling the heating value of the heat source. | 2009-05-28 |
20090137085 | METHOD OF MANUFACTURING A WIRING SUBSTRATE AND SEMICONDUCTOR DEVICE - A wiring substrate includes a base insulating film, a first interconnection formed on a top surface side of the base insulating film, a via conductor provided in a via hole formed in the base insulating film, and a second interconnection provided on a bottom surface side of the base insulating film, the second interconnection being connected to the first interconnection via the via conductor. The wiring substrate includes divided-substrate-unit regions, in each of which the first interconnection, the via conductor, and the second interconnection are formed. The wiring substrate includes a warpage-controlling pattern on the base insulating film, and has a warped shape such that when the wiring substrate is left at rest on a horizontal plate, at least a central part of each side of a plane surface of the substrate contacts the horizontal plate, with both ends of the side raised, where each of the sides extends along a second direction perpendicular to a first direction in the plane surface of the substrate. | 2009-05-28 |