21st week of 2010 patent applcation highlights part 45 |
Patent application number | Title | Published |
20100130331 | EXERCISE BICYCLE - An exercise bicycle is provided with a planar four bar linkage with cranks. The bicycle frame ( | 2010-05-27 |
20100130332 | BIOMECHANICAL EXERCISE DEVICE HAVING A RESILIENT SUPPORT SURFACE - An ankle exercise device increases user comfort and is capable of exercising each ankle without having to switch a fulcrum from one side to the other. The exercise device includes an upper section having a first stiffness characteristic and a lower section that is connected to upper section and has a second stiffness characteristic that is different than the first stiffness characteristic. A fulcrum extends from the lower section and is adapted to support the exercise device for pivoting movement relative to a floor or other support surface. | 2010-05-27 |
20100130333 | Martial Arts Striking Device with Flexible, Non-Force Impact, Relatively Non-Resistant Contact, Striking Targets, and Method of Use - A martial arts striking device and method of use that overcomes the relatively hard force impact and resistance disadvantages of all prior striking devices for martial arts, boxing, and physical fitness by allowing visibly targeted “non-force impact” (meaning relatively less forceful impact) striking at relatively “non-resistant contact” targets to enhance speed and power while using less effort. Said striking targets can be substantial in size and made of a lightweight flexible material or fabric that reacts with a spontaneous refresh rate when struck, thereby simulating a live opponent. Said striking targets can be easily suspended from a variety of existing structures or specially produced frames and supports to form familiar punching bag shapes, enclosures, or to simulate being surrounded by multiple opponents. In contrast to prior art objects, said striking device is light in weight, easier to mount, noiseless when used, and suitable for safe home use. | 2010-05-27 |
20100130334 | OFFSET WEIGHT BARS - An offset weight bar is provided which operates with the lifter's neuro-fascial connections to increase muscle activation and recruitment of muscle groups. The offset weight bar includes a grip portion that is shaped in accordance with the meuro-fascial connections in the lifter's hands and arms. The offset weight bar also offsets the weight of the bar from the lifter's palm to a point out along the lifter's unfolded fingers. The shape of the offset weight bar operates with the offset of the weight from the palm to increase the lifter's muscle activation and muscle group recruitment in accordance with the lifter's neuro-fascial physiology. | 2010-05-27 |
20100130335 | Bench press - A bench press with a first pair of upright vertical supports and a second pair of upright vertical supports. | 2010-05-27 |
20100130336 | Neuromuscular Training Apparatus and Method of Use - Neuromuscular training apparatus configured to maintain a body unit in a suitable geometry for performing neuromuscular training therapy or athletic training. The neuromuscular training apparatus comprises a center support member and a pair of transverse support members coupled to opposing ends of the center support member in a parallel spaced relationship. A plurality of arcuate members span the spaced relationship between the transverse support members. The arcuate members are axially repositionable about a common vertical axis which parallels the center support member. Each arcuate member is configured to maintain a radial element in a suitable geometry with the body unit for performing the neuromuscular training by providing a bias force, movement restriction or inhibition to a range of movement of the body unit. | 2010-05-27 |
20100130337 | EXERCISE DEVICE - An exercise device with a hand grip movable along a surface by a user. The hand grip has a braking device that allows the user to selectively prevent the hand grip from moving along the surface. The exercise device may also include optional knee/foot dollies and resistance bands. | 2010-05-27 |
20100130338 | PHYSICAL TRAINING APPARATUS AND METHOD - A resistance training apparatus and method for providing a plurality of training vectors having points of origin variable by direction and elevation to a trainee. The apparatus may accommodate a plurality of trainees and provide multiple training vectors to each trainee. The apparatus provides the training vectors by attaching tethers such as elastic cords to harnesses worn around body portions of an athlete in a configuration that allows the athlete to perform a sports-specific or therapeutic movement at an optimum speed. In one embodiment the apparatus includes a base forming the training area and a pair of tower assemblies, each providing elastic cords for attachment to the harnesses worn by the athlete. In another embodiment the apparatus provides at least sixteen training vectors to a trainee. In yet another embodiment the apparatus provides training vectors to patients or trainees who cannot fully support their own body weight. Each of the elastic cords providing the training vectors are independently adjustable such that balanced or unbalanced loading may be applied simultaneously to a trainee from multiple directions and multiple planes. | 2010-05-27 |
20100130339 | CUP INSULATING SYSTEM - The present invention provides an apparatus and a system for insulating a receptacle including a cup, bottle and/or container. Additionally, the present invention provides an apparatus and a system for providing a pre-packaged, efficient and easily transported insulator which may be utilized in a single use fashion and may be easily applied to the receptacle in which it is used to insulate. Moreover, the present invention may be easily applied to the receptacle by rolling the insulator onto the receptacle. Further, the present invention may allow for providing an advertising medium with the use of indicia on the insulator. | 2010-05-27 |
20100130340 | METHOD AND DEVICE FOR CONTAMINATION FREE LOADING AND EMPTYING - The invention relates to devices and equipment which need to be loaded and emptied contamination free, in particular it relates to a centrifuge or to a mixer. Thereby, also toxic substances shall be centrifuged with comparatively low complexity, and the centrifuge shall subsequently be emptied and prepared for further use. This is accomplished by closing the open side of the drum housing configured with the drum insert and/or of the drum insert and/or of the drum with a disposable cover. | 2010-05-27 |
20100130341 | Blue Beta-Quartz Glass-Ceramic Materials, Articles Made Thereof, and Fabrication Process - The present invention discloses a blue transparent glass-ceramic material comprising β-quartz solid solution as a predominant crystalline phase and process for making same. The glass-ceramic comprises TiO | 2010-05-27 |
20100130342 | Transparent Glass Ceramic Plate That Has An Opaque, Colored Bottom Coating Over The Entire Surface Or Over Part Of The Surface - A transparent, colorless lithium-aluminosilicate glass ceramic plate with high-quartz mixed crystals as the prevailing crystal phase, which is provided on one side with an opaque, colored, temperature-stable coating over the entire surface or over the entire surface to a large extent, is described, which has a content of Nd | 2010-05-27 |
20100130343 | CERAMICS SLIDING MEMBER FOR USE IN PURE WATER - A ceramics sliding member for use in ultrapure water or pure water of the present invention is made of an SiC sintered body. The SiC sintered body includes β-SiC at a ratio of 20% or more thereto and has an average crystal structure whose aspect ratio is 2 or greater. | 2010-05-27 |
20100130344 | High resistivity SiC material with B, N and O as the only additions - A dense silicon carbide (SiC) material with boron (B), nitrogen (N) and oxygen (O) as the only additives and with excellent insulting performance (electrical volume resistivity greater than 1×10 | 2010-05-27 |
20100130345 | SILICON NITRIDE-MELILITE COMPOSITE SINTERED BODY AND DEVICE UTILIZING THE SAME - A silicon nitride-melilite composite sintered body in accordance with the invention includes silicon nitride and a melilite Me | 2010-05-27 |
20100130346 | METHOD OF PRESSURELESS SINTERING PRODUCTION OF DENSIFIED CERAMIC COMPOSITES - Methods of making and compositions of dense sintered ceramic nano- and micro-composite materials that are highly stable in a variety of conditions and exhibit superior toughness and strength. Liquid feed flame spray pyrolysis techniques form a plurality of nanoparticles (e.g., powder), each having a core region including a first metal oxide composition comprising Ce and/or Zr or other metals and a shell region including a second metal oxide composition comprising Al or other metals. In certain aspects, the core region comprises a partially stabilized tetragonal ZrO | 2010-05-27 |
20100130347 | FORMED ARTICLE AND PROCESS FOR THE PRODUCTION THEREOF - This invention is made to provide a formed article which ensures that an active substance included therein and a substance outside capsules can effectively come in contact with each other without suffering influences such as a pressure loss, that the surface area thereof can be utilized to the utmost without having the surface of an active substance coated with a polymer, that the active substance does not easily come off or separate even when external friction or the like is exerted and that an active substance does not directly come in contact with a human body or is not sucked into a human body. | 2010-05-27 |
20100130348 | PHOTOCATALYTIC COMPOSITION FOR ANTI-REFLECTION AND THE GLASS SUBSTRATE COATED WITH THE COMPOSITION - Disclosed herein is an antireflective photocatalyst composition including a titanium dioxide-based photocatalyst, a binder, water, and alcohol, and a substrate using the composition. The antireflective photocatalyst composition is advantageous in that, when it is applied to a glass substrate, such as a glass antireflective film for a solar cell or a glass illuminator, it can prevent incident light energy from scattering and improve optical transmissivity, and in that it decomposes pollutants due to the dual action of harmful gas decomposition and self-purification, which are specific characteristics of a photocatalyst. | 2010-05-27 |
20100130349 | PREPARING PHOSPHORUS CONTAINING ALUMINA SUPPORT BY SOL-GEL METHOD FOR FISCHER-TROPSCH SYNTHESIS AND CATALYST PREPARATION THEREOF - The present invention relates to a process of preparing of a phosphorus-containing phosphorus-alumina support by a sol-gel method and a cobalt/phosphorus-alumina catalyst where cobalt is supported onto the phosphorus-alumina support as an active ingredient. The phosphorus-alumina support is prepared by a sol-gel method and has wide specific surface area with bimodal pore size distribution and high cobalt dispersion, thereby enabling to increase heat and mass transfer, stabilize the structure by modifying the surface property of alumina and decrease the deactivation rate due to the reduced oxidation of cobalt component during the F-T reaction. When Fischer-Tropsch reaction (F-T) is conducted on the catalyst, the catalyst maintains a superior thermal stability, inhibits the deactivation due to water generation during the F-T reaction and also causes relatively high conversion of carbon monoxide and stable selectivity of liquid hydrocarbons. | 2010-05-27 |
20100130350 | OXYGEN STORAGE/RELEASE MATERIAL AND EXHAUST GAS PURIFYING CATALYST COMPRISING THE SAME - There is provided an oxygen storage/release material using a rare earth oxysulfate or oxysulfide, which has a high oxygen storage/release capacity even at lower temperatures. The oxygen storage/release material of the present invention comprises a compound consisting of Pr | 2010-05-27 |
20100130351 | SYNTHESIS OF RARE EARTH ELEMENT-CONTAINING ALUMINA NANOWIRES - Rare earth element(s) doped alumina nanowires are formed by a thermal evaporation method in which vapor from aluminum powder and vapor from a rare earth element compound (such as an halide) are reacted in an oxygen-containing inert gas stream to form alumina which deposits as alumina nanowires and as a rare earth element and oxygen-containing material that deposits with and/or on the alumina nanowires. Where the RE-doped alumina nanowires are to be used as catalyst supports, a catalyst material, such as platinum, may be deposited as small particles on the nanowires. | 2010-05-27 |
20100130352 | Methods For Processing Shaped Bodies - The present disclosure relates to methods of making shaped bodies comprising providing a substantially uniform temperature and gas flow throughout the shaped body as a function of reaction time. The disclosure further relates to methods of making shaped bodies substantially uniformly oxidized. The methods comprise setting at least one shaped body and performing at least one firing of the at least one shaped body. The present disclosure further relates to shaped bodies made according to the methods disclosed. | 2010-05-27 |
20100130353 | METHOD OF PRODUCING FLUOROAPATITE, FLUOROAPATITE, AND ADSORTION APPARATUS - A method of producing a fluoroapatite is provided. The method comprises preparing a slurry containing a hydroxyapatite which has at least one hydroxyl group, preparing a hydrogen fluoride-containing solution containing a hydrogen fluoride, mixing the hydrogen fluoride-containing solution with the slurry to obtain a mixture to thereby adjust a pH of the mixture in the range of 2.5 to 5, and reacting the hydroxyapatite with the hydrogen fluoride in the mixture in a state that the pH of the mixture is adjusted within the above range to thereby obtain the fluoroapatite by substituting the at least one hydroxyl group of the hydroxyapatite with fluorine atom of the hydrogen fluoride. The method can produce the fluoroapatite having improved acid resistance by reducing an impurity, such as ammonia, derived from a raw material to a low or very low level. Further, a fluoroapatite having high acid resistance is also provided. Furthermore, an adsorption apparatus using such a fluoroapatite is provided. | 2010-05-27 |
20100130354 | NOVEL SEPARATION MATRIX - The present invention relates to a separation matrix comprised of ligands coupled to the surfaces of a porous support, such as one or more porous particles, wherein the ligands provide at least one chemical gradient within the support. In the most advantageous embodiment, the chemical gradient is a ligand density gradient. The invention also relates to a method of providing a separation matrix comprising ligands coupled to the surfaces of a porous support, in which method at least one ligand density gradient is provided by solvent-controlled diffusion of at least one reagent into the porous support. | 2010-05-27 |
20100130355 | WATER-ABSORBING POLYSACCHARIDE AND METHOD FOR PRODUCING THE SAME - A process for producing a polysaccharide superabsorbent particulate including the process steps of bringing into contact a polysaccharide with a polyphosphate or a polyphosphoric acid as crosslinking agent in the presence of water to form a polysaccharide gel drying the polysaccharide gel, comminuting the dried polysaccharide gel to form polysaccharide superabsorbent polymer particles, coating the particles with a polyphosphate or polyphosphoric acid, crosslinking the coated particles, and surface treating the particulate with a metal multivalent salt or an acid. The invention further relates to a polysaccharide superabsorbent polymer particulate obtainable by this process, a water-absorbent polysaccharide, a composite, a process for producing a composite, a composite produced by this process, the use of the polysaccharide superabsorbent particulates or of the composites as well as the use of polyphosphates. | 2010-05-27 |
20100130356 | Thermally-responsive record material - A thermally-responsive record material useful for bar coding is taught comprising a support having provided thereon in substantially contiguous relationship a heat sensitive coating comprising at least one chromogenic material, said chromogenic material being selected from a fluoran, and at least one developer of the formula (II) | 2010-05-27 |
20100130357 | PESTICIDAL COMPOSITION COMPRISING A PYRIDYLETHYLBENZAMIDE DERIVATIVE AND AN INSECTICIDE COMPOUND - A composition comprising at least a pyridylethylbenzamide derivative of general formula (I) (a) and an insecticide compound (b) in a (a)/(b) weight ratio of from 1/1000 to 1000/1. | 2010-05-27 |
20100130358 | N-CYANOALKYLANTHRANILAMIDES AS INSECTICIDES - Compounds of formula (I) wherein the substituents are as defined in claim | 2010-05-27 |
20100130359 | Fungicidal Pyridazines, Processes for Their Preparation and Their Use for Controlling Harmful Fungi, and Compositions Comprising Them - Pyridazines of the formula I | 2010-05-27 |
20100130360 | PLANT INVIGORATOR - A plant invigorator which may contain the following ingredients per litre: 10%-33% anion surfactants; 5%-18% non-ionic surfactants; 2%-20% ethanol or methylated spirits or cider vinegar; 25%-60% de-mineralised aqueous solution; 0.01 ml-4 ml natural extract such as vanilla, almond or strawberry; 0.01-5 grams food grade coloring; 0.01-5 grams lanolin or 0.5 ml-15 ml glycerine or 0.5 ml to 5 ml paraffin oil. | 2010-05-27 |
20100130361 | SAFENING 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDE INJURY ON DIRECT SEEDED AND TRANSPLANTED PADDY RICE - Herbicidal injury caused by 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylates in direct seeded and transplanted paddy rice is reduced with the use of beflubutamid, bispyribac, carfentrazone, cloquintocet, cyhalofop, daimuron, dichlormid, dimepiperate, fenchlorazole, fenclorim, fluxofenim, furilazole, halosulfuron, isoxadifen, mefenpyr, norflurazon, oxabetrinil, pyriclor, sulcotrione, AD67 and mixtures thereof. | 2010-05-27 |
20100130362 | SAFENING 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDE INJURY ON CEREAL CROPS - Herbicidal injury caused by 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylates in wheat and barley is reduced with the use of AD67 (MON 4660), benoxacor, 2-CBSU, daimuron, dichlormid, dicyclonon (BAS 145 138H), fenchlorazole-ethyl, fenclorim, fluxofenim, furilazole (MON 13900), glyphosate, isoxadifen-ethyl, mefenpyr-diethyl, naphthalic anhydride, oxabetrinil and mixtures thereof. | 2010-05-27 |
20100130363 | SAFENING COMPOSITION OF 6-(TRISUBSTITUTED PHENYL)-4-AMINO-2-PYRIDINECARBOXYLATE HERBICIDES AND CLOQUINTOCET-MEXYL FOR CEREAL CROPS - Herbicidal injury caused by 6-(trisubstituted phenyl)-4-amino-2-pyridinecarboxylates in wheat and barley is reduced with the use of low rates of cloquintocet. | 2010-05-27 |
20100130364 | OIL SUSPENSIONS OF SULPHONYLUREAS AND AGROCHEMICAL COMBINATIONS - An agrochemical formulation in the form of an oil suspension characterised in that it contains as essential elements of the formulation (percentages by weight related to the total weight of the formulation) at least; a herbicide of the sulphonylurea type at a concentration of 0.5-50%, preferably 2-30%, a paraffin mineral oil at a concentration of 10-75%, preferably without the existence of any other type of mineral or vegetable oil in the formulation and the concentration of mineral oil being 40-60%, an organomodified silane compound at a concentration of 5-40%, preferably 10-25%, with the existence of other coformulants until reaching 100% by weight of the formulation. | 2010-05-27 |
20100130365 | SAFEGUARDING SEED SAFETY OF TREATED SEEDS - The present invention relates to a method to overcome negative effects of the treatment of seeds with insecticides, acaricides or nematicides on the germination of seeds and vitality of seedlings. The inventive method markedly enhances germination and vitality of seeds that are treated with insecticides, acaricides or nematicides. The present invention describes a method that at least comprises the following steps: 1) Hydration of the seed 2) Followed by drying of the seed 3) Followed by a treatment of the seed with insecticidal, acaricidal, or nematicidal compounds. | 2010-05-27 |
20100130366 | METHOD FOR BETTER UTILISING THE PRODUCTION OF POTENTIAL TRANSGENIC PLANTS - The invention relates to a method for improving the utilization of the production potential of transgenic plants which comprises treating the plant with active compound combinations comprising an active compound from the group of the anthranilamides and at least one further insecticide. | 2010-05-27 |
20100130367 | Methods of Quantitatively Assessing Inflammation with Biosensing Nanoparticles - The present invention includes a method of using one or more biomarkers to identify individuals with inflammatory disease using Quantum Dots conjugated to targeting moieties that will specifically bind to biomarker proteins or nucleic acids encoding the biomarker, where detection of the biomarker is associated with the inflammatory disease. | 2010-05-27 |
20100130368 | Method and system for sequencing polynucleotides - Provided herein is a method of determining a sequence of a target polynucleotide. The method can include the steps of a) providing a device including an array of relatively short polynucleotides and relatively long polynucleotides immobilised on a surface of a solid support, wherein the relatively long polynucleotides are fragments of the target polynucleotide and wherein the relatively long polynucleotides are separated by a distance of at least 10 nm, whereby parts of the relatively long polynucleotides that extend beyond the relatively short polynucleotides can be individually optically resolved; and b) determining the sequence of the target polynucleotide by detecting incorporation of nucleotides into strands complementary to the relatively long polynucleotide fragments using fluorescent labels associated with the incorporated nucleotides. Also provided is system for determining a sequence of a target polynucleotide. The system can include means for carrying out steps a) and b) of the above method. | 2010-05-27 |
20100130369 | Bead-Based Multiplexed Analytical Methods and Instrumentation - Various methods, such as a method of detecting SNPs, involving (a) introducing onto a droplet actuator a solution comprising genomic DNA, extension oligos and suspension array beads; (b) dispensing on the droplet actuator one bead per droplet; (c) cleaving DNA from the bead in each droplet; (d) amplifying the cleaved DNA; (e) detecting SNP signals and barcode signals from the amplified DNA. | 2010-05-27 |
20100130370 | FLOW CELL ARRAY AND THE UTILIZATION THEREOF FOR MULTIANALYTE DETERMINATION - A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use. | 2010-05-27 |
20100130371 | SYSTEM, METHOD, DEVICE, AND COMPUTER PROGRAM PRODUCT FOR EXTRACTION, GATHERING, MANIPULATION, AND ANALYSIS OF PEAK DATA FROM AN AUTOMATED SEQUENCER - A system, method, device, and computer program product to extract and gather peak information from an automated sequencer of bioinformatics into a peak database, and to manipulate and analyze the peak information within the database. | 2010-05-27 |
20100130372 | ALGORITHMS FOR CLASSIFICATION OF DISEASE SUBTYPES AND FOR PROGNOSIS WITH GENE EXPRESSION PROFILING - Methods for generating a normalized expression signal for microarray data based on a theoretical distribution at the unit level to produce a normalized expression signal for the single microarray that is independent of other microarrays. The method typically includes receiving microarray data representing a plurality of probe pairs for a single microarray, determining, for each probe pair, differences between intensities of perfect match (PM) probes and intensities of mismatched (MM) probes, determining a difference signal, D, based on the determined differences, and scaling the difference signal, D, to produce an expression signal, DS. The method also typically includes normalizing the expression signal based on a theoretical distribution at the unit level to produce a normalized expression signal for the single microarray that is independent of other microarrays. | 2010-05-27 |
20100130373 | MAPPING OF GENOMIC INTERACTIONS - The present invention relates to genomic analysis. In particular, the present invention provides methods and compositions for mapping genomic interactions. | 2010-05-27 |
20100130374 | HIGH-THROUGHPUT DIAGNOSTIC TESTING USING ARRAYS - The present invention relates to arrays comprising between 2 and 12.000 nucleic acid molecules, comprising a first set of nucleic acid molecules that comprise a nucleotide sequence that is able to hybridize to a gene that is used for normalization. The array may further comprise a second set of nucleic acid molecules that comprise nucleic acid sequences capable of hybridizing to nucleic acid molecules that are expressed in clinical relevant samples such as, for example, breast tissue. The invention further relates to a method for normalizing data. Further provided are methods of using an array according to the invention for distinguishing clinical samples. | 2010-05-27 |
20100130375 | APOLIPOPROTEIN AII ASSAY METHOD FOR THE IN VITRO DIAGNOSIS OF COLORECTAL CANCER - The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the Apolipoprotein AII tumor marker in a biological sample taken from a patient suspected of having colorectal cancer. Said method can be used for early diagnosis, screening, therapeutic follow-up and prognosis, and also for relapse diagnosis in relation to colorectal cancer. | 2010-05-27 |
20100130377 | PREDICTING CANCER OUTCOME - This document provides methods and materials related to assessing prostate cancer in mammals. For example, this document provides nucleic acids and polypeptides that can be analyzed to determine whether a male mammal having prostate cancer is susceptible to a good or poor outcome. | 2010-05-27 |
20100130378 | MICROARRAY-BASED LINEAGE ANALYSIS AS A DIAGNOSTIC FOR CURRENT AND EMERGING STRAINS OF INFLUENZA B - Embodiments herein provide for methods, compositions and apparatus for detection and/or diagnosis of pathogenic virus lineage and/or strains. In some embodiments, the virus is influenza Type B virus. In other embodiments, an apparatus may include a microarray with attached capture probes, designed to bind to nucleic acid sequences from a single gene in a broad array of influenza strains. In some embodiments, compositions may include isolated nucleic acid sequences of use as capture probes, target sequences and/or label probe sequences, for diagnosis of and/or detection of influenza virus. | 2010-05-27 |
20100130379 | Weighted Chemiluminescent Chip array Method for Multiple Marker Detection - A gene chip for chemiluminescent detection is obtained. The chip uses multiple markers. Weighted scores are given to genes separately according to their influences on forming a cancer. The present invention provides an objective and accurate disease assistant diagnosis with a low cost, a high sensitivity and a good performance. The present invention can be widely applied to personal medical behaviors, like clinical diagnosis, treatment filtration, prognosis review, preventive medicine, etc. | 2010-05-27 |
20100130380 | Biochip substrate and biochip - A biochip substrate which is free from cross-contamination due to spot spreading or contact with spots adjacent to each other, and a biochip using the same. A biochip substrate on which multiple valleys for immobilizing biological substances are formed so as to prevent cross-contamination due to spot spreading or contact with spots adjacent to each other, and a biochip using the same are provided. Moreover, it is found out that a desired binding in a target molecule contained in a test sample occurs at a detectable level in a solution system even in the case where a valley have such a small capacity as 1 nL to 10 nL. | 2010-05-27 |
20100130381 | NOVEL HIV-1 REVERSE TRANSCRIPTASE CODON DELETION AND ITS USE IN THE MANAGEMENT AND TREATMENT OF HIV INFECTIONS - The present invention provides an isolated HIV-1 mutant and isolated nucleic acid molecules comprising HIV-RT coding sequences harboring a novel mutation in the S68 codon, and in particular, deletions of the S68 codon. This novel deletion reduces the sensitivity of HIV to various nucleoside reverse transcriptase inhibitors. Methods of using this mutation for selecting effective antiretroviral agents in vitro and in vivo, methods for monitoring infection progression in HIV-infected individuals and methods for avoiding the emergence of and/or to treat individuals infected with HIV comprising mutations at the S68 codon of HIV-RT, e.g., S68del, are provided. | 2010-05-27 |
20100130382 | Liposome, Proteoliposome, Biochip, and Method for Producing Liposome and Proteoliposome - A liposome comprising a region of a lipid bilayer membrane with different membrane thicknesses, wherein each lipid bilayer membrane region is composed of a different lipid, and a thick membrane side in the region of the lipid bilayer membrane is formed of lipid having a phase transition temperature higher than that of the lipid forming a thin membrane side in the region of the lipid bilayer membrane. A proteoliposome, wherein the above-described liposome includes membrane proteins. A biochip, wherein the above-described liposome or the above-described proteoliposome is spread on a substrate. The above-described biochip, wherein the substrate includes at least one kind selected from the group consisting of mica, SiO | 2010-05-27 |
20100130383 | METHODS AND COMPOSITIONS IN PARTICLE-BASED DETECTION OF TARGET MOLECULES USING COVALENT BOND FORMING REACTIVE PAIRS - Methods and compositions which can be used to increase the strength and/or probability of forming a binding complex comprising a target molecule and a substrate are disclosed. In one aspect, linking molecules having one or more members of a reactive pair are disclosed which can be used to increase the number of intra-complex binding interactions in a complex comprising a target molecule and a substrate. Intra-complex crosslinking and inter-complex crosslinking can be utilized in connection with these methods and compositions to further strengthen and stabilize the disclosed binding complexes. | 2010-05-27 |
20100130384 | Compositions and Methods for Removal of Asphaltenes from a Portion of a Wellbore or Subterranean Formation - Compositions are provided for removing an organic material, especially asphaltenes, from a portion of a wellbore or a subterranean formation. The composition comprises: (A) water, wherein the water is greater than 50% by volume of the composition; (B) an organic solvent blend that is immiscible with water, wherein the organic solvent comprises: (i) a non-polar organic solvent; and (ii) a polar organic solvent; and (C) a surfactant adapted for forming an emulsion of the organic solvent blend and the water. Methods are provided for removing an organic material from a portion of a wellbore or a subterranean formation. The method comprises the steps of: (A) forming a composition according to the invention; and (B) introducing the composition to the portion from which the organic material is to be removed. | 2010-05-27 |
20100130385 | PRODUCTION AND USE OF PARAFFIN INHIBITOR FORMULATIONS - A process for preparing a paraffin inhibitor formulation comprising (a) preparing a mixture comprising a waxy paraffin inhibitor component having a melting point of >0° C. and an emulsifier component, wherein the mixture is prepared at a first temperature range above the melting point of the waxy paraffin inhibitor; (b) adding water to the mixture to produce an o/w emulsion; and (c) cooling the o/w emulsion to a temperature in a second temperature range which is below the melting point of the waxy paraffin inhibitor. The mixture prepared in step (a) may further comprise water to produce a w/o emulsion, the water being present in a proportion by weight that is lower than the sum of the proportions by weight of the paraffin inhibitor and the emulsifier component. The process may further comprise (d) adding an at least partially water-miscible organic solvent in which the paraffin inhibitor is insoluble. | 2010-05-27 |
20100130386 | Solvent For Extracting Bitumen From Oil Sands - The use of a solvent for bitumen extraction, either from mined oil sands or in situ. The solvent includes (a) a polar component, the polar component being a compound comprising a non-terminal carbonyl group; and (b) a non-polar component, the non-polar component being a substantially aliphatic substantially non-halogenated alkane. The solvent has a Hansen hydrogen bonding parameter of 0.3 to 1.7 and/or a volume ratio of (a):(b) in the range of 10:90 to 50:50. | 2010-05-27 |
20100130387 | Method and Facility for Treating Waste Drilling Mud - A method is provided of recycling and decontaminating oil-based waste drilling mud and cuttings contaminated with oil-based waste drilling mud. A facility for performing the method is also provided. The method includes removing the coarse solids from the mud, breaking the emulsion, and separating the hydrophobic phase from the water phase and the solid phase. The solids may then be treated by either or both of two approaches. One approach involves vaporizing all residual oil and water from the solids, and burning off the vaporized oil. Another approach involves at least partially vaporizing the residual oil from the solids and recondensing the oil. The method produces a solid “soil” product that is free from oil contamination (or is sufficiently decontaminated to allow reuse), an oil product that is fit for reuse, and clean air emissions. A thermal desorber or a soil dryer can be used to efficiently vaporize the oil at low temperature. Optionally the water fraction of the mud can be vaporized, solutes and salts can be captured as evaporite and then be mixed with the soil product. The method has the unique advantage of producing no persistent hazardous waste. The method has the further advantage of requiring no external input of energy if the reclaimed oil is used to provide energy for the process. The method has the further advantage of recycling portions of the drilling mud that would otherwise be subject to disposal. | 2010-05-27 |
20100130388 | METHOD FOR TREATING WELL BORE IN A SUBTERRANEAN FORMATION WITH HIGH DENSITY BRINES AND COMPLEXED METAL CROSSLINKERS - The invention discloses a method of treating a wellbore by providing an aqueous mixture of a hydrated polysaccharide with a salt; adding to the mixture a cross-linking agent for cross-linking the hydrated polysaccharide, wherein the cross-linking agent comprises a zirconium compound, glutamic acid, and a polyol; pumping the aqueous mixture of the hydrated polysaccharide and the cross-linking agent into the wellbore; and cross-linking the hydrated polysaccharide. | 2010-05-27 |
20100130389 | Compositions and Methods for Removal of Asphaltenes from a Portion of a Wellbore or Subterranean Formation Using Water-Organic Solvent Emulsion with Non-Polar and Polar Organic Solvents - Compositions are provided for removing an organic material, especially asphaltenes, from a portion of a wellbore or a subterranean formation. The composition comprises: (A) water; (B) an organic solvent blend further comprising: (i) a non-polar organic solvent; and (ii) at least two polar organic solvents; and (C) a surfactant adapted for forming an emulsion of the organic solvent blend and the water. According to another aspect of the invention, the compositions comprise: (A) water, wherein the water is greater than 25% by volume of the composition; (B) an organic solvent blend further comprising: (i) a non-polar organic solvent; and (ii) a polar organic solvent; and (C) a surfactant adapted for forming an emulsion of the organic solvent blend and the water. Methods are provided for removing an organic material from a portion of a wellbore or a subterranean formation. The method comprises the steps of: (A) forming a composition according to the invention; and (B) introducing the composition to the portion from which the organic material is to be removed. | 2010-05-27 |
20100130390 | Multifunctional Driveline Fluid - A composition including 1 to 20 weight percent of a compound having a traction coefficient of at least about 0.045, at least 50 weight percent of an oil of lubricating viscosity, a phosphorus compound and 2,5-dimercapto-1,3,4-thiadiazole or a derivative thereof, and having a kinematic viscosity at 100° C. of up to about 12 mm2/sec, is suitable for lubricating a transmission. | 2010-05-27 |
20100130391 | PREPARATION OF STERICALLY HINDERED HYDROXYPHENYLCARBOXYLIC ACID ESTERS - A novel manufacturing process is described for producing hindered phenolic alkyl esters, which may be useful as antioxidants. This process simplifies catalyst neutralization and removal during the preparation of hindered phenolic esters. Compositions that comprise the hindered phenolic esters produced according to these methods are also described. | 2010-05-27 |
20100130392 | LUBRICANT CONCENTRATE CONTAINING A PHOSPHATE TRIESTER - The present invention relates to a lubricant concentrate containing the following components
| 2010-05-27 |
20100130393 | Ester Dispersant Composition for Soot Handling in EGR Engines - Reaction of a carboxylic acid-containing polymer with certain aromatic amines and polyols results in ester containing dispersant viscosity modifiers with improved soot handling performance in heavy-duty diesel engines, compared with non-ester containing dispersants. | 2010-05-27 |
20100130394 | HYDRAULIC FLUID AND HYDRAULIC SYSTEM - A hydraulic fluid of the present invention contains, as a base oil, an ester having two or more ring structures, the two or more ring structures being at least one selected from an aromatic ring and a saturated naphthenic ring. Particularly, the hydraulic fluid contains an ester having two or more aromatic rings as the base oil. The hydraulic fluid has low energy loss due to compression and exhibits excellent responsiveness when being used in a hydraulic circuit. Consequently, the hydraulic fluid realizes energy-saving, high-speed operation and high precision of control in the hydraulic circuit. | 2010-05-27 |
20100130395 | LUBRICANT BASE OIL, METHOD FOR PRODUCTION THEREOF, AND LUBRICANT OIL COMPOSITION - The lubricating base oil of the invention is characterized by having an urea adduct value of not greater than 4% by mass and a viscosity index of 100 or greater. The process for production of a lubricating base oil according to the invention is characterized by comprising a step of hydrocracking/hydroisomerization of a stock oil containing normal paraffins, until the obtained treatment product has an urea adduct value of not greater than 4% by mass and a viscosity index of 100 or greater. A lubricating oil composition according to the invention is characterized by comprising the lubricating base oil of the invention. | 2010-05-27 |
20100130396 | ANTIOXIDANT COMPOSITIONS - The invention relates to antioxidant compositions for lubricants and organic polymers comprising a first antioxidant comprising a reaction product of p-cresol, dicyclopentadiene and isobutylene; and a second antioxidant comprising a diarylamine. The first antioxidant preferably has the structure: | 2010-05-27 |
20100130397 | 4-Isoamylcyclohexanol as Odiferant - The use of | 2010-05-27 |
20100130398 | METHOD OF DECONTAMINATING A POROUS SURFACE CONTAMINATED WITH CESIUM - A method of decontaminating porous surfaces contaminated with water soluble radionuclides by contacting the contaminated porous surfaces with an ionic solution capable of solubilizing radionuclides present in the porous surfaces followed by contacting the solubilized radionuclides with a gel containing a radionuclide chelator to bind the radionuclides to the gel, and physically removing the gel from the porous surfaces. A dry mix is also disclosed of a cross-linked ionic polymer salt, a linear ionic polymer salt, a radionuclide chelator, and a gel formation controller present in the range of from 0% to about 40% by weight of the dry mix, wherein the ionic polymer salts are granular and the non cross-linked ionic polymer salt is present as a minor constituent. | 2010-05-27 |
20100130399 | SELF ADHESIVE HARD SURFACE CLEANING COMPOSITION - The present invention relates to hard surface cleaning compositions, and their use. It is an object of the present invention to provide a hard surface cleaning composition providing hygiene to a hard surface, whilst being easily positioned onto a hard surface; even a wet surface. The present invention provides a hard surface cleaning composition, which is at least partially transparent or translucent, characterized in that it comprises a surfactant system forming a liquid crystalline phase in the presence of water and biocide material. | 2010-05-27 |
20100130400 | TOILET CLEANING BLOCK - The present invention relates to toilet cleaning blocks, and their use, in particular toilet cleaning blocks providing hygiene to a hard surface, wherein such a block is at least partially transparent or translucent appearance, in a solid, semi solid, or gel form. Accordingly the present invention provides a toilet cleaning block, which is at least partially transparent or translucent, and comprising a biocide and a carrier composition comprising soap, humectant and solvent. | 2010-05-27 |
20100130401 | PROTEIN HYDROLYSATE AND PLANT STEROL CONTAINING COMPOSITION FOR IMPROVING SERUM LIPID PROFILE AND PREVENTING ATHEROSCLERORIS - The invention relates to a terapeutical composition comprising a protein hydrolysate and a plant sterol, wherein the weight ratio of the plant sterol to the protein hydrolysate is from 1:0.02 to 1:150. The invention also relates to a terapeutical composition comprising a protein hydrolysate and a synthetic emulsifier and/or a lipid based grain fraction having emulsifying properties. Said compositions can be used in a pharmaceutical, nutraceutical or food product for improving serum lipid profile. | 2010-05-27 |
20100130402 | Biomarkers for insulin resistance and beta-cell dysfunction - The invention provides compositions and methods for determining insulin resistance and/or pancreatic β-cell dysfunction in a subject. The invention also provides compositions and methods for treating a subject according to the insulin resistance and/or pancreatic β-cell dysfunction in the subject. | 2010-05-27 |
20100130403 | Biomarkers for insulin efficacy - The invention provides compositions and methods for determining insulin efficacy in a subject. The invention also provides compositions and methods for treating a subject according to the efficacy of insulin in the subject. | 2010-05-27 |
20100130404 | Biomarkers for cardiodiabetes - The invention provides compositions and methods for determining cardiodiabetes status in a subject. The invention also provides compositions and methods for treating a subject experiencing cardiodiabetes. | 2010-05-27 |
20100130405 | BIGLYCAN AND RELATED THERAPEUTICS AND METHODS OF USE - The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Example of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders. | 2010-05-27 |
20100130406 | GLYCATED MILK AND USES THEREOF - Milk-based products and drinks are provided including specified forms of identified proteins or fragments thereof, as are methods for the use of such milk-based products and drinks in the promotion of sleep. | 2010-05-27 |
20100130407 | FACILITATION OF RESUSCITATION FROM CARDIAC ARREST BY ERYTHROPOIETIN - The present invention relates generally to the use of erythropoietin (EPO) to facilitate resuscitation from cardiac arrest. For a mammalian subject suffering from cardiac arrest, concurrent administration of EPO with resuscitation after the onset of ventricular fibrillation facilitates the resuscitation. Administration of EPO serves to attenuate myocardial abnormalities caused by cardiac arrest and the resuscitation efforts and favor improved resuscitation outcomes. The main effect of EPO that facilitates resuscitation is the preservation of left ventricular myocardial distensibility leading to improve left ventricular preload and the amount of blood ejected by chest compression. This effect enables higher coronary perfusion pressures to be generated resulting in a higher rate of return of spontaneous circulation and higher survival rates. The very same effect enables the return of spontaneous circulation to occur faster reducing the time a human subject is in cardiac arrest. These effects lead to a higher number of cardiac arrest victims to survive and to do so with intact neurological function in most of the survivors. | 2010-05-27 |
20100130408 | USE OF MODIFIED CYCLOSPORINS - Disclosed are non-immunosuppressive cyclophilin-binding cyclosporine having useful properties in the prevention or treatment of liver diseases. | 2010-05-27 |
20100130409 | CYCLIC PEPTIDE CXCR4 ANTAGONISTS - Provided are lactam-cyclized peptide CXCR4 antagonists useful in the treatment of cancers, rheumatoid arthritis, pulmonary fibrosis, and HIV infection. | 2010-05-27 |
20100130410 | Neural regeneration peptides and methods for their use - Embodiments of this invention include novel peptides that can promote survival of neurons and other cell types. Other embodiments of this invention include the methods for the use of peptides to promote neuronal migration, neurite outgrowth, neuronal proliferation, neural differentiation, neuronal survival and/or trophoblast proliferation, trophoblast migration and trophoblase survival. NRP compounds may be administered directly to a subject or to a subject's cells by a variety of means including orally, intraperitoneally, intravascularly or indirectly via a replicable vehicle. NRP compounds can be formulated into pharmaceutically acceptable dosage forms for therapeutic use. Kits containing pre-determined doses of an NRP can be used to conveniently store, prepare and administer an NRP to a subject in need thereof. | 2010-05-27 |
20100130411 | METHOD FOR TREATING CARTILAGE DISORDERS - The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor. | 2010-05-27 |
20100130412 | Compositions to prevent and treat type-1 diabetes - The present invention is based on the discovery that Humanin and humanin analogues protect pancreatic beta cells in vitro and in vivo from apoptosis. Accordingly, humanin and its analogues are useful for preventing and treating diabetes and promoting beta cell survival in a number of applications. | 2010-05-27 |
20100130413 | TREATMENT FOR AGE-RELATED MACULAR DEGENERATION AND OTHER DISEASES OF THE EYE - A method is disclosed for treating diseases or disorders of the eye involving undesired neovascularization by administration of a complement inhibitory protein such as soluble complement receptor type I (sCR1). The present invention relates to the direct treatment of macular degeneration, particularly age-related macular degeneration (AMD), by administering a complement inhibitory protein intraocularly or systemically. | 2010-05-27 |
20100130414 | Methods of Using E2F2 for the Treatment of Hypertension - The present invention features compositions and methods of treating or preventing hypertension or a cardiac indication. In particular embodiments, the invention provides E2F2 as a new therapeutic target for the treatment of hypertension or a cardiac indication, and methods of increasing the expression and/or activity of E2F2. | 2010-05-27 |
20100130415 | Stem cell secreted product derived compositions for wound treatment - Compositions including formulations comprising secreted products obtained from the culture medium of stem cells, such as umbilical cord blood stem cells, or embryonic germ cell derivatives, or embryonic stem cells, are provided for enhancement of wound healing. Further compositions contain components identified in such culture medium to enhance wound healing. Methods for using the compositions and formulations for enhancing wound healing are also provided. Wounds to both soft and bony tissues are encompassed, and include wounds created by surgical procedures. | 2010-05-27 |
20100130416 | MODULATION OF ANGIOGENESIS BY A-BETA PEPTIDE FRAGMENTS - Provided are Aβ peptide fragments that are useful in inhibiting angiogenesis. Also provided are methods for the treatment of pathological or unwanted angiogenesis and conditions and diseases associated therewith by administering an effective amount of an Aβ fragment. In a particular embodiment, the peptide fragment includes the sequence HHQKLVFF. | 2010-05-27 |
20100130417 | TRANSFORMING GROWTH FACTOR ALPHA HII - The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders, and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptides and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention. | 2010-05-27 |
20100130418 | P2X7 Inhibition Of Epithelial Cancers And Papillomas - The present invention demonstrates that P2X | 2010-05-27 |
20100130419 | Artery- and Vein-Specific Proteins and Uses Therefor - Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis. This distinction can be used to advantage in methods to alter angiogenesis, methods to assess the effect of drugs on artery cells and vein cells, and methods to identify and isolate artery cells and vein cells, for example. | 2010-05-27 |
20100130420 | NOVEL CHIMERIC LIGAND-GATED ION CHANNELS AND METHODS OF USE THEREOF - The present invention provides novel chimeric receptors that have unique pharmacology. In particular, the chimeric receptors comprise a mutated ligand binding domain of the α7 nicotinic acetylcholine receptor fused to a transmembrane or channel domain from a ligand-gated ion channel protein. The mutations in the ligand binding domain confer selective binding of compounds. Methods of using the novel chimeric receptors of the invention as well as compounds that preferentially bind and activate the chimeric receptors are also disclosed. | 2010-05-27 |
20100130421 | BIOMODULATORS FOR TREATMENT OR PREVENTION OF DISEASE - The invention provides methods and compositions for the treatment or prevention of animal disease whereby the compositions are biomodulators of plant physiological activity. Inventive methods include administration of one or more biomodulators to an animal such as human for the treatment of cell proliferation or differentiation diseases such as cancer. | 2010-05-27 |
20100130422 | USE OF COCOA EXTRACT - A cocoa extract obtainable by the extraction of non-defatted cocoa beans which have not been fermented or have been allowed to ferment for no more than three days, having a polyphenol content of more than 25% by weight, may be used in the treatment or alleviation of obesity. | 2010-05-27 |
20100130423 | TREATMENT OF MYELOPROLIFERATIVE DISORDERS WITH ADAPTOR PROTEIN LNK - Janus kinase 2 (JAK2) associates with cytokine receptors and is essential for signal transduction in hematopoietic cells. The JAK2 mutation, JAK2 V617F, prevalent in myeloproliferative disorders, confers cytokine-independent proliferation and constitutive activation of downstream signaling pathways, when co-expressed with homodimeric type I cytokine receptors. The adaptor protein LnK is a negative regulator of hematopoietic cytokine receptors, including EPOR and MPL. LnK attenuates wild type JAK2 signaling in hematopoietic Ba/F3 cells expressing MPL. LnK also inhibits cytokine-independent growth and signaling conferred by JAK2 V617F in those cells. LnK, via its SH2 domain, PH domain, and other regions, associates with JAK2 and JAK2 V617F. Additional LnK domains are involved in LnK downregulation of JAK2 V617F constitutive activation. Elucidating the pathways that attenuate JAK2 and JAK2 V617F signaling provides insight into myeloproliferative disorders and helps to develop therapeutic approaches. Inhibition of Lnk enhances the expression of hematopoetic stem cells and hematopoetic progenitor cells. | 2010-05-27 |
20100130424 | CRHR2 PEPTIDE AGONISTS AND USES THEREOF - The present invention relates to novel peptides that are selective corticotrophin releasing hormone receptor type 2 (CRHR2) agonists and compositions thereof for the treatment, amelioration or inhibition of cardiovascular conditions, including but not limited to heart failure. The novel peptide agonist preferably comprise modifications that include pegylated peptides. Furthermore, the present invention also relates to methods for the treatment and prevention of a disease or disorder related to CRHR2 activity. | 2010-05-27 |
20100130425 | USE OF TOLL-LIKE RECEPTOR LIGANDS IN TREATING EXCITOTOXIC INJURY, ISCHEMIA AND/OR HYPOXIA - Methods of protecting cells against cytotoxic insults are provided. The methods involve administering a composition including a Toll-like receptor (TLR) ligand, for instance a TLR7, TLR8, or TLR9 ligand to a subject. The methods are applicable to the protection of neural and non-neural cells. For example, methods of protecting a neural cell against excitotoxic brain injury are provided. Methods for preparing medicaments for the prophylactic treatment of excitotoxic injury, ischemia and/or hypoxia are also provided. Also provided are compositions for use in the described methods. | 2010-05-27 |
20100130426 | COMPOSITIONS CONTAINING SATIOGENS AND METHODS OF USE - Provided herein are methods and compositions for treating metabolic diseases and conditions associated with metabolic diseases. | 2010-05-27 |
20100130427 | POLYMER-FACTOR VIII MOIETY CONJUGATES - Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient. | 2010-05-27 |
20100130428 | POLYMER FACTOR IX MOIETY CONJUGATES - Conjugates of a Factor IX moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided (among other things) are compositions comprising the conjugates, methods of making the conjugates, and methods of administering to a patient compositions comprising the conjugates. | 2010-05-27 |
20100130429 | BBS10 RELATED DIAGNOSTIC METHODS AND REAGENTS FOR BARDET-BIEDL SYNDROME - The present invention relates to the identification of a gene, designated BBS1O, that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypertension, mental retardation, renal cancer and other abnormalities, retinopathy and hypogonadism. Methods of use for the gene, for example in diagnosis and therapy of BBS, also are described. | 2010-05-27 |
20100130430 | STABILIZED THERAPEUTIC SMALL HELICAL ANTIVIRAL PEPTIDES - Provided are constrained peptides that inhibit HIV assembly. Pharmaceutical compositions comprising the above peptides are also provided. Additionally provided are methods of inhibiting replication of a capsid-containing virus in a cell. Also provided are methods of treating a mammal infected with a capsid-containing virus. Further provided are methods of treating a mammal at risk for infection with a capsid-containing virus. Methods of making the above peptides are additionally provided, as are uses of the above peptides and pharmaceutical compositions. | 2010-05-27 |
20100130431 | DISCORDANT HELIX STABILIZATION FOR PREVENTION OF AMYLOID FORMATION - The invention is based on the discovery that the presence of a discordant helix in a protein or peptide is predictive of that protein or peptide's ability to form amyloid. The invention includes methods for detecting discordant helices and methods of screening for compounds that stabilize the α-helix of a discordant helix-containing polypeptide. Compounds discovered using these methods are useful for treating or preventing disorders in which amyloid is produced. Such disorders include Alzheimer's disease and prion-associated disorders. | 2010-05-27 |