21st week of 2013 patent applcation highlights part 61 |
Patent application number | Title | Published |
20130131289 | SELF LIMITING CATALYST COMPOSITION FOR ETHYLENE POLYMERIZATION - A process for polymerizing ethylene to produce an ethylene-based polymer including contacting ethylene with a Ziegler-Natta procatalyst, an alkylaluminum cocatalyst and a self limiting agent selected from the group of aliphatic, cycloaliphatic, substituted cycloaliphatic or aromatic esters, anhydrides and amides such that the self limiting agent reduces polymerization rates to no greater than 40% of the polymerization rate in the absence of the self limiting agent at temperatures equal to or greater than 120° C. is provided. | 2013-05-23 |
20130131290 | CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS - A catalyst component for the polymerization of olefins comprising Mg, Ti and at least two electron donor compounds, one of which (A) belonging to specific diolesters and the other electron donor compound (B) being selected from aromatic monoesters of the following formula (B) in which R groups equal to or different from each other, are selected from C | 2013-05-23 |
20130131291 | SOLID PARTICULATE CATALYSTS COMPRISING BRIDGED METALLOCENES - A polypropylene homopolymer with a melting point of less than 147° C., a percentage of 2.1 errors of at least 1% and a xylene soluble fraction of less than 0.5 wt %. | 2013-05-23 |
20130131292 | CATALYST FOR POLYMERIZATION OF OLEFINS COMPRISING THIENYL-SUBSTITUTED SILANES - Disclosed is a catalyst for the polymerization of olefins comprising thienyl-substituted silanes, which comprises a solid titanium catalyst component containing titanium, magnesium and a halogen as the main components, an alkylaluminum compound, and a component of organosiloxane compound comprising two thienyl as substituents represented by general formula (I). The molar ratio of each catalyst component is 1:50-150:5-50 based on titanium:aluminum:silicon. When the catalyst is used in the polymerization of propylene, the polymerisate obtained has very high degree of isotacticity, and the yield is high. | 2013-05-23 |
20130131293 | CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS - Catalyst component for the polymerization of olefins comprising Mg, Ti and an electron donor of Formula (I) in which R, R | 2013-05-23 |
20130131294 | Amidinate Catalyst Compounds, Process for Their Use and Polymers Produced Therefrom - This invention relates to a method to polymerize olefins comprising contacting olefins with an amidinate catalyst compound, a chain transfer agent and an activator, where the amidinate catalyst compound is represented by the formula: (amindinate) | 2013-05-23 |
20130131295 | Catalyst Compounds and Use Thereof - This invention relates to Group 4 catalyst compounds containing anionic bidentate nitrogen/oxygen based ligands catalyst compounds useful for polymerization and or oligomerization of unsaturated monomers. The catalyst compounds are particularly useful, with or without activators, to polymerize olefins, particularly α-olefins, or other unsaturated monomers. | 2013-05-23 |
20130131296 | TI CATALYST SYSTEMS COMPRISING SUBSTITUTED CYCLOPENTADIENYL, AMIDINE AND DIENE LIGAND - The invention relates to a catalyst system for the polymerization of olefins comprising a metal complex of formula CyLMD and an activating cocatalyst, wherein M is titanium, Cy is a cyclopentadienyl-type ligand, D is a diene, L is an amidinate-containing ligand of formula (1), wherein the amidinate-containing ligand is covalently bonded to the titanium via the imine nitrogen atom, Sub | 2013-05-23 |
20130131297 | SYNTHESIS OF DENDRITIC POLYOLEFINS BY METATHESIS INSERTION POLYMERIZATION - A one step process for making a dendritic hydrocarbon polymer, e.g., dendritic polyolefin, by metathesis insertion polymerization. The process comprises polymerizing an amount of one or more cyclic olefins and one or more multi-functional (meth)acrylates in the presence of a metathesis catalyst and under conditions sufficient to produce the dendritic hydrocarbon polymer. The one or more multi-functional (meth)acrylates have a functionality of 3 or higher. The dendritic hydrocarbon polymer can be hydrogenated to produce a substantially saturated dendritic hydrocarbon polymer. The hydrogenation can take place in the same reaction vessel as the polymerization, i.e., one pot process. | 2013-05-23 |
20130131298 | HYDROLYSIS-RESISTANT SILICONE COMPOUNDS - In one aspect, the invention relates to hydrolysis-resistant silicone compounds. In particular, disclosed are sterically hindered hydrolysis-resistant silicone compounds and improved purity hydrolysis-resistant silicone compounds. Also disclosed are processes for making hydrolysis-resistant silicone compounds; the products of the disclosed processes; compositions and polymers comprising the disclosed compounds and products of the disclosed processes; and ophthalmic lenses, for example contact lenses, intraocular lenses, artificial cornea, and spectacle lenses, comprising the disclosed compositions, disclosed polymers, disclosed compounds, and products of the disclosed processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2013-05-23 |
20130131299 | PROCESS FOR PRODUCING CARBOXYL-CONTAINING POLYMER COMPOSITION, AND CARBOXYL-CONTAINING POYLMER COMPOSTION - A process is disclosed for producing a carboxyl-containing polymer composition that allows the possibility of obtaining a carboxyl-containing polymer composition which exhibits excellent dispersibility in water or the like, has a viscosity increasing to a lower degree compared to the viscosity of a neutralized viscous liquid using an additive-free carboxyl-containing polymer, and has a high degree of transparency in a neutralized viscous liquid thereof. A carboxyl-containing polymer composition is obtained by polymerizing a monomer containing an α,β-unsaturated carboxylic acid as a main component in a presence of a polyol (iso)stearic acid ester. A polyol in the polyol (iso)stearic acid ester is a polyol selected from a specific group, and the polyol (iso)stearic acid ester is used in the polymerization in an amount of 0.2 to 7 parts by mass based on 100 parts by mass of the α,β-unsaturated carboxylic acid. | 2013-05-23 |
20130131300 | PROCESS AND APPARATUS FOR MIXING AND SPLITTING FLUID STREAMS - A process for continuously mixing at least two fluid streams and splitting the stream of the mixture into at least two partial streams, comprising a) providing streams of the at least two fluids via separated conduits; b) combining the streams of the fluids and forming a homogeneous mixture; c) measuring the pressure in the conduit conveying the mixture of the fluids; d) splitting the stream of the mixture of the fluids into at least two partial streams and feeding each of the partial streams to a conduit equipped with a flow control device controlled by a controller; and e) adjusting the flow rates of the partial streams of the mixture of the fluids by feeding the pressure information measured in step c) as process variable to the controllers controlling the flow control devices, a process for feeding a mixture of at least two fluids via at least two feeding points, an apparatuses for carrying out such processes and a process for polymerizing olefins. | 2013-05-23 |
20130131301 | Method for Making Waterborne Polyurethane with a Reactive Functional Group and a Nanocomposite Made of the Same - Disclosed is a method for making waterborne polyurethane with a reactive functional group. The method includes the step of introducing a short-chain diol monomer with a reactive functional group into waterborne polyurethane polymer by pre-polymerization to provide a polyurethane pre-polymer with the reactive functional group connected to a side chain and the step of reacting the pre-polymer with hydrophilic diamine for chain extension and inter-crosslink to provide waterborne polyurethane with different crosslink degree. The short-chain diol monomer is expressed by structural formula (I) and the polyurethane pre-polymer with the reactive functional group connected to the side chain is expressed by structural formula (II) as follows: | 2013-05-23 |
20130131302 | SOY-BASED POLYOLS - The invention provides processes for preparing soy-based oligomeric polyols or substituted oligomeric polyols, as well as urethane bioelasteromers comprising the oligomeric polyols or substituted oligomeric polyols. | 2013-05-23 |
20130131303 | MATERIAL FOR FIBER MANUFACTURING AND FIBER - Disclosed is a material for fiber manufacturing obtained by melt kneading while degassing a liquid crystal polyester satisfying the following requirements (a) and (b): | 2013-05-23 |
20130131304 | MATERIAL FOR FIBER MANUFACTURING AND FIBER - Disclosed is a material for fiber manufacturing comprising a liquid crystal polyester satisfying the following requirements (a) and (b): | 2013-05-23 |
20130131305 | Simplified Production of Nylon-6 - A process for producing polyamides from the corresponding monomers and/or prepolymers comprises the steps of
| 2013-05-23 |
20130131306 | PROCESSES FOR PRODUCING CAPROLACTAM AND DERIVATIVES THEREOF FROM FERMENTATION BROTHS CONTAINING DIAMMONIUM ADIPATE OR MONOAMMONIUM ADIPATE - Processes for producing caprolactam (CL) and derivatives thereof from adipic acid (AA) obtained from fermentation broths containing diammonium adipate (DAA) or monoammonium adipate (MAA). | 2013-05-23 |
20130131307 | PROCESS FOR PREPARING PA-4X, AND PA-410 OBTAINABLE BY THE PROCESS - A process for preparation of a polyamide PA-4X containing monomer units of 1,4-diaminobutane and an aliphatic linear dicarboxylic acid X with at least 8 carbon atoms, which contains the following steps: 1) making a solution comprising a salt of 1,4-diaminobutane and the aliphatic linear dicarboxylic acid and water, at a temperature at which the salt dissolves; 2) concentrating the solution of the salt at a temperature above the crystallization temperature of the salt, at a pressure of at most 7 barA to a water content of between 0 and 30 wt % based on the total amount of solution, 3) producing a polymer from the solution obtained by step 2, while keeping the polymer in a melt and at a pressure of less than 18 barA, 4) depressurizing the polymer obtained at step 3 while keeping the polymer in the melt to further polymerize the polymer. In an preferred embodiment the aliphatic linear dicarboxylic acid is 1,10-decanedioic acid. Also claimed is a polyamide 410 having a viscosity number (VN) of at least 100 ml/gram. | 2013-05-23 |
20130131308 | Catalytic System for Co2/Epoxide Copolymerization - The present invention related to a method of manufacturing a polycarbonate including the process of copolymerizing epoxide compound and CO2 using cobalt(III) or chromium(III), where the ligands contains at least 3 ammonium cations, central metal has formal −1 charge, and conjugated anions of the two cationic ammonium groups are acid-base homoconjugation, as catalyst. | 2013-05-23 |
20130131309 | SYNTHESIS OF HIGH MOLECULAR WEIGHT PEO USING NON-METAL INITIATORS - A new synthetic method to prepare high molecular weight poly(ethylene oxide) with a very narrow molecular weight distribution (PDI<1.5) is described. The method involves a metal free initiator system, thus avoiding dangerous, flammable organometallic compounds. | 2013-05-23 |
20130131310 | DRUG-LIGAND CONJUGATES, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO - The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: (I) wherein each of X, Alk, and W are as defined and described herein. | 2013-05-23 |
20130131311 | AZIRIDINE MEDIATED NATIVE CHEMICAL LIGATION - Improved methods of native chemical ligation are provided. The methods involve reacting a thioacid (e.g. a peptide thioacid) with an aziridinyl compound (e.g. an aziridinyl peptide) under mild conditions without the use of protecting groups, and without requiring that a cysteine residue be present in the ligation product. Initial coupling of the thioacid and the aziridinyl compound yields a ligation product which contains an aziridinyl ring. Subsequent opening of the aziridinyl ring (e.g. via a nucleophilic attack) produces a linearized and modified ligation product. | 2013-05-23 |
20130131312 | PEPTIDE CONJUGATED, INOSINE-SUBSTITUTED ANTISENSE OLIGOMER COMPOUND AND METHOD - A therapeutic oligomer-peptide conjugate, and methods of using the conjugate are disclosed. The conjugate includes (a) a substantially uncharged oligonucleotide analog compound having a base sequence that includes a string of bases that are complementary to four or more contiguous cytosine bases in a target nucleic acid region to which the compound is intended to bind, and (b) conjugated to the compound, an arginine-rich peptide effective to enhance the uptake of the compound into target cells. The string of bases in the compound includes at least one inosine base positioned in the string so as to limit the number of contiguous guanine bases in said string to three or fewer. The conjugate has greater cellular uptake than the compound alone, by virtue of the arginine-rich peptide, and substantially greater antisense activity greater activity than the conjugate in the absence of inosine-for guanine substitutions. | 2013-05-23 |
20130131313 | EEF2K ASSAYS FOR IDENTIFYING COMPOUNDS THAT INHIBIT EEF2K ACTIVITY - Assays for identifying novel compounds for inhibiting eEF2 kinase and consequence peptides employed therein. | 2013-05-23 |
20130131314 | Peptide Derivatives for Biofunctionalization of Silicon Substrates and Their Applications - The present invention relates to the use of a peptide consisting of 5 to 30 amino acid residues comprising an amino acid sequence selected from LLADTTHHRPWT (SEQ ID NO: 1), SPGLSLVSHMQT (SEQ ID NO: 2), and the sequences presenting at least 80% identity with SEQ ID NO: 1 or SEQ ID NO: 2, for the funcfionalization of silicon substrate. The present invention also relates to the specific peptides as such, and to silicon substrates functionalized by the adsorption on their surface of such specific peptides. Finally, the present invention is also directed to a process for the preparation of such functionalized silicon substrates, and to articles comprising a silicon substrate according to the invention. | 2013-05-23 |
20130131315 | AUTO-PROCESSING DOMAINS FOR POLYPEPTIDE EXPRESSION - Embodiments herein include methods and constructs that can be used to co-express two or more polypeptides of interest from a single polynucleotide encoding a precursor polypeptide. Within this precursor polypeptide can reside at least one autonomous processing unit, which can mediate release of flanking polypeptides of interest in cis. The processing unit can include an N-terminal autocatalytic cleavage domain and a C-terminal cleavage domain. Some embodiments include constructs and methods for co-expressing polypeptides without N- or C-terminal overhangs, in any cellular or extracellular location, and/or in stoichiometric ratios. | 2013-05-23 |
20130131316 | PREPARATION OF CANOLA PROTEIN ISOLATE FROM CANOLA OIL SEEDS ("BLENDERTEIN") - Canola protein isolate is recovered from canola oil seeds by crushing the oil seeds and extracting the crushed canola oil seeds. Fat co-extracted from the crushed oil seeds is removed from the aqueous canola protein solution which then is processed by the micellar route to obtain the canola protein isolate. | 2013-05-23 |
20130131317 | EXPRESSION OF SECRETED HUMAN ALPHA-FETOPROTEIN IN TRANSGENIC ANIMALS - The invention features a process of expressing secreted recombinant human alpha-fetoprotein (rHuAFP) in the milk or urine of transgenic mammals. | 2013-05-23 |
20130131318 | SINGLE UNIT ANTIBODY PURIFICATION - The present invention relates to a method for the purification of antibodies from a protein mixture produced in a bioreactor, at least comprising the steps of intermediate purification and polishing, wherein the intermediate purification and polishing step comprises in-line anion exchange chromatography (AEX) treatment and hydrophobic interaction chromatography (HIC) treatment in flow through mode. The present invention further relates to a single operational unit comprising both an anion exchange chromatography part and a hydrophobic interaction chromatography part, which are serially connected, wherein the unit comprises an inlet at the upstream end of the anion exchange chromatography part and an outlet at the downstream end of the hydrophobic interaction chromatography part and wherein the unit also comprises an inlet between the anion exchange chromatography part and the hydrophobic interaction chromatography part. | 2013-05-23 |
20130131319 | ANTIBODIES WITH MODIFIED AFFINITY TO FCRN THAT PROMOTE ANTIGEN CLEARANCE - An objective of the present invention is to provide methods for facilitating antigen-binding molecule-mediated antigen uptake into cells, methods for facilitating the reduction of antigen concentration in plasma, methods for increasing the number of antigens to which a single antigen-binding molecule can bind, methods for improving pharmacokinetics of antigen-binding molecules, antigen-binding molecules improved for facilitated antigen uptake into cells, antigen-binding molecules capable of facilitating the reduction of antigen concentration in plasma, antigen-binding molecules capable of repeatedly binding to antigens, antigen-binding molecules with improved pharmacokinetics, pharmaceutical compositions comprising such an antigen-binding molecule, and methods for producing those described above. The present inventors discovered that antigen uptake into cells is facilitated by an antibody having human FcRn-binding activity at the plasma pH and a lower antigen-binding activity at the early endosomal pH than at the plasma pH; such antibodies can increase the number of antigens to which a single antibody molecule can bind; the reduction of antigen in plasma can be facilitated by administering such an antibody; and antibody pharmacokinetics can be improved by using such antibodies. | 2013-05-23 |
20130131320 | HIGHLY-FUNCTIONAL MUTANT OF HUMANIZED ANTI-EGFR ANTIBODY VARIABLE REGION | 2013-05-23 |
20130131321 | LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY - The present invention relates to the use for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material, the ligand being represented by formula (I) | 2013-05-23 |
20130131322 | ANTIBODY BEING CAPABLE OF BINDING TO TRANSFORMING GROWTH FACTOR ALPHA AND HAVING GROWTH-SUPPRESSING ACTIVITY ON CANCERS HAVING RAS GENE MUTATION - It has been found out that among antibodies showing reactivity with wild type TGF-α, antibodies less reactive with G79A-substituted TGF-α have an excellent growth-suppressing effect on cancer cells having a mutated Ras gene. Further, it has been found out that most of these antibodies have an activity of inhibiting EGFR tyrosine phosphorylation and/or an induction-suppressing activity on vascular endothelial cells. | 2013-05-23 |
20130131323 | METHOD FOR STORAGE AND STABILIZATION OF A TARGET SUBSTANCE - The invention relates to a system and method for the stable storage of sensitive biological or chemical target substance, in a bound form on certain capture media. The method comprised providing a sample containing the target substance in a suitable buffer; combining the sample with a capture media to effect reversible binding of the target substance to the capture media; and storing the capture media with the target substance at between about −20 and 20° C.; and recovering the target substance from the capture media. The target substance recovered maintains the desired activity. Also provides are methods for reducing aggregates in the sensitive biological or chemical target substance. | 2013-05-23 |
20130131324 | Novel Fluorescent Dyes and Uses Thereof - The present invention provides fluorescent dyes that are based on firefly luciferin structure. These dyes are optimally excited at shorter wavelengths and have Stokes shift of at least 50 nm. The fluorescent dyes of the invention are useful for preparation of dye-conjugates, which can be used in detection of an analyte in a sample. | 2013-05-23 |
20130131325 | GLYCOPROTEIN SYNTHESIS AND REMODELING BY ENZYMATIC TRANSGLYCOSYLATION - A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an activated oligosaccharide moiety, in the presence of a catalyst comprising endoglycosidase (ENGase), to transfer the oligosaccharide moiety to the acceptor and yield the homogeneous glycoprotein or glycopeptide. The donor substrate includes, in a specific implementation, a synthetic oligosaccharide oxazoline. A related method of glycoprotein or glycopeptide remodeling with a predetermined natural N-glycan or a tailor-made oligosaccharide moiety, and a method of remodeling an antibody including a heterogeneous sugar chain, are also described. The disclosed methodology enables glycoprotein drugs to be modified for prolonged half-life in vivo, reduced immunogenicity, and enhanced in vivo activity, and for targeting and drug delivery. | 2013-05-23 |
20130131326 | PROCESS FOR PRODUCTION OF PRECIPITATED LIGNIN FROM BLACK LIQUOR AND PRECIPITATED LIGNIN PRODUCED BY THE PROCESS - The present invention relates to a process tor the production of precipitated lignin from black liquor wherein the process comprises the steps of providing a black liquor stream treating the black liquor at an increased temperature and precipitating the lignin from the heat treated black liquor. The present invention further relates to precipitated lignin produced according to the process and use of the precipitated lignin produced. | 2013-05-23 |
20130131327 | Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging - Chelators of the formulae (I), (II) and (III) | 2013-05-23 |
20130131328 | PROCESS FOR PRODUCING REFINED NUTRACEUTIC EXTRACTS FROM ARTICHOKE WASTE AND FROM OTHER PLANTS OF THE CYNARA GENUS - Process for fractioning and refining natural products obtainable from waste vegetal material and particularly from artichoke ( | 2013-05-23 |
20130131329 | METHODS AND COMPOSITIONS FOR DETECTING GASTROINTESTINAL AND OTHER CANCERS - This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as neoplasia of the upper or lower gastrointestinal tract, pancreas, and/or bladder. | 2013-05-23 |
20130131330 | BIDIRECTIONAL PROMOTERS IN NANNOCHLOROPSIS - Exemplary embodiments provided herein include novel promoters isolated from the microalgae, | 2013-05-23 |
20130131331 | CANCER-CELL-SPECIFIC CYTOSTATIC AGENT - The present inventors discovered that although suppressing expression of the RecQ1 gene, a RecQ helicase family gene, shows suppressive effects on cell proliferation in cancer cells, such effects are not observed in human TIG3 cells (a normal diploid fibroblast cell line), which are normal cells. Hence, the present inventors discovered that siRNAs against RecQ1 gene have cancer cell-specific cell proliferation-suppressing effects that are mediated by suppression of the expression of said gene. | 2013-05-23 |
20130131332 | METHOD FOR PRODUCTION OF CELLULOSE NANO CRYSTALS FROM CELLULOSE-CONTAINING WASTE MATERIAL - A process is disclosed for recovering pure cellulose from a cellulose-containing sludge, the process comprising treating a sludge cellulose source under conditions permitting dissolution of non-cellulose material and suspension of the cellulose, wherein said dissolution conditions do not alter cellulose morphology. | 2013-05-23 |
20130131333 | CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION - This invention provides cellulose ester interpolymers, and methods of oxidizing cellulose interpolymers and cellulose ester interpolymers. The invention also provides routes to access carboxylated cellulose ester derivatives with high acid numbers wherein the carboxyl group is attached directly to the cellulose backbone by a carbon-carbon bond. Through functionalization of an intermediate aldehyde, the corresponding cationic or zwitterionic cellulose ester derivatives can also be accessed. The interpolymers of the present invention have a number of end-use applications, for example, as binder resins in various types of coating compositions and as drug delivery agents. | 2013-05-23 |
20130131334 | METHOD FOR THE SYNTHESIS OF A TRISACCHARIDE - The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates. | 2013-05-23 |
20130131335 | METHODS FOR THE PREPARATION OF DROSPIRENONE AND INTERMEDIATES THEREOF - The invention relates to a process for the preparation of Drospirenone in high yields and purity starting from a compound of formula 2 | 2013-05-23 |
20130131336 | CARBAZOLE LINKED PYRROLO[2,1-C][1,4]BENZODIAZEFINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides a compound of general formulae A useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine hybrids of general formulae 6a-g, 10a-o, 14a-g and 18a-o. | 2013-05-23 |
20130131337 | OPTICALLY ACTIVE AMMONIUM SALT COMPOUND, PRODUCTION INTERMEDIATE THEREOF, AND PRODUCTION METHOD THEREOF - An optically active bisbenzyl compound or a racemic bisbenzyl compound represented by formula (2) that has axial chirality. An optically active azepine derivative or a racemic azepine derivative represented by formula (3). Methods of producing an optically active quaternary ammonium salt compound represented by formula (8). | 2013-05-23 |
20130131338 | SUBSTITUTED DIKETOPIPERAZINES AS OXYTOCIN ANTAGONISTS - A method of treating or preventing diseases or conditions mediated through the action of oxytocin which comprises administering to a human in need thereof of an effective amount of a compound of the formula (I) or a pharmaceutically acceptable salt thereof. | 2013-05-23 |
20130131339 | Process for Producing SN-Comprising Catalysts - The present invention relates to a process for producing a supported tin-comprising catalyst, wherein a solution (S) comprising tin nitrate and at least one complexing agent is applied to the support, where the solution (S) does not comprise any solid or has a solids content of not more than 0.5% by weight based on the total amount of dissolved components. | 2013-05-23 |
20130131340 | LIGANDS FOR ESTROGEN RELATED RECEPTORS AND METHODS FOR SYNTHESIS OF SAID LIGANDS - Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described. | 2013-05-23 |
20130131341 | NOVEL POLYMORPHS OF ERLOTINIB HYDROCHLORIDE AND METHOD OF PREPARATION - The present invention relates to three novel crystalline forms of Erlotinib hydrochloride and method of preparation thereof. Erlotinib hydrochloride is N-(3-ethynylphenyl)-6,7-bis(2-methoxy ethoxy)-4-quinazolinamine hydrochloride of formula-(I). The present invention provides stable novel crystalline forms of Erlotinib hydrochloride designated as Form-M, Form-N and Form-P, and processes for the preparation of the same. Erlotinib hydrochloride can be used as medicament for the treatment of hyperproliferative disorders, such as cancers, in humans. | 2013-05-23 |
20130131342 | AGENT EXHIBITING THE PROPERTIES OF A COGNITIVE FUNCTION PROMOTER (EMBODIMENTS) - The present invention relates to the field of chemical-pharmaceutical industry and medicine. An agent, exhibiting the properties of a cognitive function promoter, was selected from 1,3-dimethyl-5-[(4-pyridylamino)methylene]barbituric acid and 4-amino-1-(3 -nitro-2-oxo-1-pheny-1 ,2-dihydro-1 ,6-naphthyridin-5-yl)pyridinium chloride. The compounds, that are proposed as agents, exhibit potent biological activity. | 2013-05-23 |
20130131343 | MICROWAVE-ASSISTED SYNTHESIS OF N-HETEROCYCLIC CARBENE TRANSITION METAL COMPLEXES - Microwave heating is used to synthesize NHC-transition metal complexes. Reaction times for the formation of NHC-transition metal complexes is greatly reduced. The speed of the reactions allows for otherwise problematic air handling of reagents. Apparatus for carrying out the reactions is less complex than conventional apparatus and requires less energy to achieve the desired temperatures. Methods utilize salts of NHC's which overcomes the oftentimes difficult preparation of free carbenes for formation of the corresponding transition metal complexes. | 2013-05-23 |
20130131344 | ORGANO-METALLIC FRAMEWORKS DERIVED FROM CARBENOPHILIC METALS AND METHODS OF MAKING SAME - The disclosure provides organic frameworks comprising increased stability. | 2013-05-23 |
20130131345 | LUMINESCENT COMPOUNDS, METHOD OF PREPARATION OF LUMINESCENT COMPOUNDS AND APPLICATIONS THEREOF - This invention relates to compounds of general formula (R′) | 2013-05-23 |
20130131346 | Dye for dye-sensitized solar cell and Solar cell using it - Disclosed is a new dye for dye-sensitized solar cell and a solar cell prepared using the dye. A new compound of dye is esterificated to add carboxylate group to alkyl chain, thereby improving stability on electrolyte and semiconductor particles. | 2013-05-23 |
20130131347 | Process for Preparing Pyridyl-Substituted Pyrazoles - The present invention relates to a process for preparing 1-pyridyl-substituted pyrazoles, comprising the reaction of acetyleneketones with pyridylhydrazine derivatives to give 1-pyridyl-substituted dihydro-1H-pyrazoles, the further reaction thereof with elimination of water to give 1-pyridyl-substituted trihalomethylpyrazoles, and the further processing thereof. | 2013-05-23 |
20130131348 | PROCESS FOR PRODUCING AMIDE COMPOUND - There is provided a process for producing an amide compound having an excellent harmful arthropod-controlling activity and represented by the formula (3): | 2013-05-23 |
20130131349 | PROCESS FOR PRODUCING AMIDE COMPOUND - There is provided a process for producing an amide compound having an excellent harmful arthropod-controlling activity and represented by the formula (3): | 2013-05-23 |
20130131350 | PYRIDIN-2YL SULFANYL ACID ESTERS AND PROCESS FOR THE PREPARATION THEREOF - The present invention relates to Pyridin-2-yl sulfanyl acid ester compounds having antiinflammatory properties. The present invention particularly relates to novel anti-inflammatory heterocyclic acid esters of Pyridin-2-yl sulfanyl having the structure of general formula 1 which have been screened for their antiinflammatory activity with respect to inhibition of adhesion of neutrophils, isolated from human peripheral blood, onto the surface of human umbilical vein endothelial cells (HU-VEC) as a result of inhibition of the cytokine-stimulated expression of cell adhesion molecule ICAM-1. The compound RS—Z, 3-(Pyridin-2-yl sulfanyl)-propionic acid pentyl ester (structure 1a, R | 2013-05-23 |
20130131351 | GPR120 RECEPTOR AGONISTS AND USES THEREOF - GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control. | 2013-05-23 |
20130131352 | Process for Preparing 1-phenylpyrazoles - The present invention to a process for preparing 1-phenylpyrazoles of the formula I | 2013-05-23 |
20130131353 | CATALYSTS FOR RING-CLOSING METATHESIS - A catalyst composition is provided, which may be used for ring closing metathesis. In the composition, a catalyst is immobilized on a siliceous mesocellular foam support. A suitable catalyst for use in the composition is a Grubbs-type catalyst or a Hoveyda-Grubbs-type catalyst. | 2013-05-23 |
20130131354 | Naphthocyanines for Use as Contrast Agents - Cyanine dyes having optional sulfonic acid substituents on the aromatic nucleus have been developed for use as contrast agents for assisting in surgery and diagnosis, especially for simplifying the surgical removal of basal membranes of the eye, such as the internal limiting membrane (ILM), and for dyeing the lens capsule. | 2013-05-23 |
20130131355 | SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF - Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described. | 2013-05-23 |
20130131356 | PREPARATION OF PROTECTED ALPHA-KETO BETA-AMINO ESTERS AND AMIDES - The invention provides β-sulfonamide α-keto esters and amides in which the α-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides. | 2013-05-23 |
20130131357 | METHOD FOR PREPARING WHITE CARBON BLACK MODIFIED BY SILANE COUPLING AGENT - The invention relates to a method for preparing silica modified by a silane coupling agent. The method comprises the following steps: preparing a kind of coupling agent sol solution by mixing the solvent, water, catalyst and coupling agent; uniformly dispersing silica into the sol solution by means of ultrasonic dispersion or shear dispersion to achieve a turbid solution with uniform dispersion and ideal particle size; and then stirring the turbid solution at a constant speed to make the coupling agent sol reacting with silica to prepare highly hydrophobic silica modified by the coupling agent through controlling the temperature and reaction time. The coupling agent sol solution is obtained by a sol-gel process and silica is uniformly dispersed in the coupling agent sol solution through combined action of various dynamic means to ensure the sufficient reaction between silica and coupling agent, thus to obtain silica modified by the coupling agent. | 2013-05-23 |
20130131358 | Novel Process for the Preparation of Dronedarone - The subject of the invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-di-n-butylamino)-propoxy]benzoyl}benzofuran-5-yl]-methanesulfonamide of formula I: | 2013-05-23 |
20130131359 | PROCESSES AND INTERMEDIATES FOR PREPARING STERIC COMPOUNDS - This invention relates to processes and intermediates for the preparation of an alpha-amino beta-hydroxy acid of Formula 1 | 2013-05-23 |
20130131360 | BIORENEWABLE NAPHTHA - The present invention generally relates to a method for producing a naphtha product from a renewable feedstock. The method includes hydrotreating the renewable feedstock to produce a hydrotreating unit heavy fraction that includes n-paraffins, and hydrocracking the hydrotreating unit heavy fraction to produce a hydrocracking unit product that includes the naphtha product. The method also includes separating the naphtha fraction and optionally recycling the hydrocracking unit heavy fraction through the hydrocracking unit. The present invention also relates to a biorenewable naphtha product suitable for use as feed stock for steam crackers and catalytic reforming units, and for use as fuel, or fuel blend stock. | 2013-05-23 |
20130131361 | NOVEL MEDICAL APPLICATION OF LIPID DERIVATIVES OF DOPAMINE AND THE METHODS OF THEIR PRODUCTION - A medical application of N-oleoyl-dopamine and 3′-O-methyl-N-oleoyl-dopamine for the production of a medication for treatment or prophylaxis of disturbances or states due to deficiency of dopamine, preferably chosen from the group covering oxygen deficiencies (hypoxia) in anesthetized and awake mammals, breathing with atmospheric oxygen (normoxia), for the respiratory responses to hypoxia in mammals, lack of dopamine binding to the membrane system in the mammalian brain, disturbances in metabolic pathways of dopamine metabolism, states of dopamine deficiencies provoked by morbid or genetic factors as well as under condition connected to the physiological process of aging of the organism, through the systemic introduction of the compound to the mammalian organism. A method of production of 3′-O-methyl-N-oleoyl-dopamine in vitro is also disclosed. | 2013-05-23 |
20130131362 | PROCESS FOR PURIFICATION OF VEGETABLE OILS UPON WITHDRAWAL OF SOLIDS BY CENTRIFUGATION IN THE MISCELLA STAGE - Process for purification of vegetable oils upon withdrawal of solids by centrifugation in the miscella stage consists of the industrial extraction of vegetable oils, including the soybean oil by using a solvent, usually a mixture of hydrocarbons, in which the main constituent is hexane. The percolation extractors that operate continuously and in countercurrent provide an optimized extraction and a good performance. The replacement of the traditional miscella purification processes by a process of Centrifugation in the mixture of oil and solvent (miscella) within the process with the removal of solids contained therein, returning it to the extractor results in final products as oil and lecithin of a better quality, also providing a better functioning of the process by avoiding fouling in heat exchangers and distillation of solvent, reducing downtime and lower fuel consumption resulting in lower production costs. | 2013-05-23 |
20130131363 | Surfactant Composition for Agricultural Chemicals - A surfactant composition for agricultural chemicals, containing fatty acid polyoxyalkylene alkyl ether expressed by the following general formula (I), | 2013-05-23 |
20130131364 | SEPARATING BIOMASS FROM AN AQUEOUS MEDIUM - Method for isolating biomass from an aqueous medium comprising cellular material comprising the steps of: 1) providing an aqueous medium comprising cellular materialalgae; followed by 2) subjecting the cellular materialalgae in said aqueous medium to lysis, whereby a lipid fraction comprising algal lipids and a solids fraction comprising algal solid material are formed, which fractions are dispersed in said aqueous medium; 3) separating at least part of said lipid fraction from the aqueous medium; 4) separating at least part of said solids fraction from the aqueous medium; wherein steps 3) and 4), and preferably also step 2), are performed in a single apparatus. The method is particularly suitable for isolating lipids from algae. | 2013-05-23 |
20130131365 | Esters with Antimicrobial, Bioresistant and Fungal Resistant Properties - A bromine/nitro moiety linked into the backbone of an ester or other compound over a wide range of occurrence rates provides antimicrobial, bio-resistant and fungal resistant properties for metal working fluids (MWF)s and other coatings. The moiety can be have the bromo and nitro groups linked to the same or different carbon atoms. The present invention also relates to urethanes, urea, amides, imides, carbonates, ethers, siloxanes, and many other types of linkages essential to MWF bases. | 2013-05-23 |
20130131366 | Metal Complex Compound and Process for Producing Amides Utilizing the Metal Complex Compound - A catalyst contains a metal complex compound represented by the following general formula (I). In the formula (I), M is a metal ion such as ruthenium, L | 2013-05-23 |
20130131367 | ANTI-BRAIN-TUMOR DRUG - A drug containing a metal-salen complex compound which is effective for a brain tumor is provided. The present invention is an anti-brain-tumor drug containing a metal-salen complex compound represented by the following Chemical Formula (I). In the formula, M represents a metal atom which is Fe, Cr, Mn, Co, Ni, Mo, Ru, Rh, Pd, W, Re, Os, Ir, Pt, Nd, Sm, Eu, or Gd, and X represents a halogen atom. | 2013-05-23 |
20130131368 | PROCESS FOR PREPARATION OF 1,2-DIAMINO-CYCLOHEXANE-PLATINUM (II) COMPLEXES - The present invention is directed to a manufacturing process for 1,2-diamino-cyclohexane-platinum(II) complexes, specifically to a manufacturing process for oxaliplatin. | 2013-05-23 |
20130131369 | HYDROLYSIS-RESISTANT SILICONE COMPOUNDS - In one aspect, the invention relates to hydrolysis-resistant silicone compounds. In particular, disclosed are sterically hindered hydrolysis-resistant silicone compounds and improved purity hydrolysis-resistant silicone compounds. Also disclosed are processes for making hydrolysis-resistant silicone compounds; the products of the disclosed processes; compositions and polymers comprising the disclosed compounds and products of the disclosed processes; and ophthalmic lenses, for example contact lenses, intraocular lenses, artificial cornea, and spectacle lenses, comprising the disclosed compositions, disclosed polymers, disclosed compounds, and products of the disclosed processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2013-05-23 |
20130131370 | METHOD FOR PRODUCING 2-CYANOACETIC ACID ANHYDRIDE AND FURTHER REACTION PRODUCTS THEREOF - The present invention relates to a process for producing 2-cyanoacetic acid anhydride, comprising the steps of a) preparing a reaction mixture, containing as reactants 2-cyanoacetic acid, and at least one C | 2013-05-23 |
20130131371 | PROCESS FOR PRODUCING AMIDE COMPOUND - There is provided a process for producing an amide compound having an excellent harmful arthropod-controlling activity and represented by the formula (3): | 2013-05-23 |
20130131372 | PREPARATION OF CHALCONE DERIVATIVES - The invention relates to methods for producing chalcone (1,3-diphenylprop-2-en-1-one) derivatives that have multiple substitutions on a phenyl ring. Intermediate chalcone derivatives are modified by Phase Transfer Catalysis (PTC) for introducing a substituted alkyl group that is provided by a sulfonic acid derivative on a phenyl ring already containing substituent groups on one or two carbon atoms adjacent to the carbon atom where a substituent group is being introduced. The methods of the invention allow producing efficiently, by either S-alkylation or O-alkylation, chalcones derivatives that are characterized for their biological activities that are intermediate compounds for producing molecules having such activities, or that can be used for generating libraries of compounds to be screened by means of in vitro and/or in vivo assays and establishing structure-activity relationships. | 2013-05-23 |
20130131373 | PENTAERYTHRITOL TETRAESTER - A pentaerythritol tetraester which is a mixed ester of pentaerythritol and carboxylic acids is provided, wherein the carboxylic acids comprise isobutyric acid and 2-ethylhexanoic acid and the molar ratio of isobutyric acid to 2-ethylhexanoic acid in the carboxylic acids is 36/64 to 83/17. The pentaerythritol tetraester may be used in a refrigerant oil or the like which exhibits excellent miscibility with a difluoromethane refrigerant among other properties. | 2013-05-23 |
20130131374 | PENTAERYTHRITOL TETRAESTER - A pentaerythritol tetraester which is a mixed ester of pentaerythritol and carboxylic acids is provided, wherein the carboxylic acids consist of isobutyric acid and 3,5,5-trimethylhexanoic acid and the molar ratio of isobutyric acid to 3,5,5-trimethylhexanoic acid in the carboxylic acids is 36/64 to 80/20. The pentaerythritol tetraester may be used in a refrigerant oil or the like which exhibits excellent miscibility with a difluoromethane refrigerant among other properties. | 2013-05-23 |
20130131375 | PROCESS FOR PREPARING DIFLUOROACETIC ACID, SALTS THEREOF OR ESTERS THEREOF - A process for preparing difluoroacetic acid, salts thereof or esters thereof is described. The process can further include preparation of difluoroacetic acid, salts thereof or esters thereof, wherein the reaction occurs in the presence of water of a salt providing a fluoride anion and of monohalogenated or dihalogenated acetic acid, in acid, salified or esterified form, at least one halogen atom being other than the fluorine atom. | 2013-05-23 |
20130131376 | METHOD FOR PRODUCING A CARBOXYLIC ACID ESTER - A method for producing a carboxylic acid ester is described, particularly an acetic acid ester and specifically an ethyl acetate ester. Also described, is a method by which a carboxylic acid ester goes from an organic phase produced from an esterification reaction between a carboxylic acid and an alcohol. The organic phase can include, at least predominantly, the carboxylic acid ester and also minor amounts of alcohol and water. Further described, is a separation step, during which the organic phase is depleted of alcohol and free of carboxylic acid via a liquid-liquid extraction operation that is performed by placing said organic phase in contact with an aqueous phase, thus enabling the alcohol and the carboxylic acid, that are present in the organic phase, to be extracted to the aqueous phase. | 2013-05-23 |
20130131377 | METHOD FOR PRODUCING ISOCYANATES IN THE GAS PHASE - The invention relates to a process for the preparation of isocyanates by reaction of the corresponding amines with phosgene in the gas phase, wherein a diluent containing between 90.0000% by weight and 99.9999% by weight of substances which are inert in the phosgenation process and between 0.0001% by weight and 10.0000% by weight of oxygen is present during the conversion of the amine into the gas phase and the molar ratio of amine to oxygen (O | 2013-05-23 |
20130131378 | PROCESS FOR PREPARING 4-NITRO-OXY-METHYL-BENZOIC ACID - This invention relates to a new process for preparing 4-nitro-oxy-methyl-benzoic acid, comprising the following steps: a) reaction of 4-chloromethyl-benzoic acid with silver nitrate and in the presence of an acid as a catalyst in acetonitrile at reflux temperature, followed by cooling and adding of a polar aprotic solvent; b) separation of the silver salts by filtration, followed by washout with a polar aprotic solvent; c) precipitation of the 4-nitro-oxy-methyl-benzoic acid with water from the filtrate obtained in step b); and d) drying of the 4-nitro-oxy-methyl-benzoic acid. | 2013-05-23 |
20130131379 | METHOD FOR PREPARING CARBOXYLIC ACIDS BY OXIDATIVE CLEAVAGE OF A VICINAL DIOL - The present invention relates to a method for preparing carboxylic acids, in particular mono- and dicarboxylic acids, by oxidative cleavage of a vicinal diol. | 2013-05-23 |
20130131380 | PROCESS FOR THE SELECTIVE OXIDATION OF CARBON MONOXIDE - The invention relates to a process of the selective oxidation of carbon monoxide to carbon dioxide present in a gas mixture comprising at least one hydrocarbon or a hydrocarbon derivative, and to its integration into a process for producing hydrocarbon derivatives. The process according to the invention comprises a step that consists in bringing said gas mixture into contact with a solid catalyst capable of oxidizing carbon monoxide to carbon dioxide at a chosen temperature, characterized on that said step is carried out in a fluidized bed. | 2013-05-23 |
20130131381 | METHOD FOR PRODUCING POLYAMIDE - A process for the manufacture of polyamide is described. Also described, is a process comprising a stage of initial polymerization under pressure starting from monomers and a stage of finishing in the liquid phase at atmospheric pressure. The finishing stage can employ an injection of inert gas along a direction essentially parallel to that of the flow of the liquid reaction stream. | 2013-05-23 |
20130131382 | Process For The Preparation Of Contrast Agents - The present invention relates to a process for the preparation of 5-[(2-hydroxyacyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamidic derivatives comprising the Smiles rearrangement of a suitable precursor, by contact of an aqueous solution of this latter with an anion exchanger solid phase. | 2013-05-23 |
20130131383 | Controlled Assembly of Charged Nanoparticles Using Functionalized Graphene Nanomesh - A method, an apparatus and an article of manufacture for attracting charged nanoparticles using a graphene nanomesh. The method includes creating a graphene nanomesh by generating multiple holes in graphene, wherein each of the multiple holes is of a size appropriate to a targeted charged nanoparticle, selectively passivating the multiple holes of the graphene nanomesh to form a charged ring in the graphene nanomesh by treating the graphene nanomesh with chemistry yielding a trap with an opposite charge to that of the targeted nanoparticle, and electrostatically attracting the target charged nanoparticle to the oppositely charged ring to facilitate docking of the charged nanoparticle to the graphene nanomesh. | 2013-05-23 |
20130131384 | PROCESS FOR RESTORING CATALYST ACTIVITY - The present invention relates to a process for restoring the activity of spent catalysts for the hydrogenation of aromatic nitro compounds, in which a regeneration comprising at least a first burning off stage, a first washing stage, a second burning off stage and a second washing stage is carried out at periodic intervals. | 2013-05-23 |
20130131385 | Process for Preparing Ethylamines and Monoisopropylamine (MIPA) - A process for preparing ethylamines and monoisopropylamine (MIPA), in which bioethanol is reacted with ammonia in the presence of hydrogen and of a heterogeneous catalyst to give ethylamines, said bioethanol having a content of sulfur and/or sulfur compounds of ≧0.1 ppm by weight (calculated S), and then isopropanol is reacted with ammonia in the presence of the same catalyst and in the presence of hydrogen to give MIPA. | 2013-05-23 |
20130131386 | BRANCHED SECONDARY ALCOHOL ALKOXYLATE SURFACTANTS FOR TEXTILE PROCESSING - Provided is a composition that is useful for textile processing, including for softening and providing smoothness to textiles The composition comprises an alkoxylate of the formula (I): wherein AO, EO, m, n, R. R | 2013-05-23 |
20130131387 | METHODS AND COMPOUNDS FOR IMPROVING SULFIDE SCAVENGING ACTIVITY - Methods for reducing sulfides from fluid streams are provided. The methods comprise adding secondary amine-formaldehyde adduct (SAFA) scavengers to fluid streams. The SAFA scavengers added comprise less than about 40 wt % N-methyl secondary amines of the total weight of SAFA scavengers. Methods for distilling N-methyl secondary amines from secondary amine-formaldehyde adduct (SAFA) scavengers are also provided. Purified SAFA scavengers are also disclosed. | 2013-05-23 |
20130131388 | PROCESS FOR RECOVERING MONOALKYLBENZENE - The invention relates to a process for recovering monoalkylbenzene from a gas stream comprising oxygen and monoalkylbenzene, wherein the gas stream comprising oxygen and monoalkylbenzene is contacted with a liquid stream comprising polyalkylbenzene, a compound comprising two phenyl groups connected to each other via a C | 2013-05-23 |