21st week of 2013 patent applcation highlights part 46 |
Patent application number | Title | Published |
20130129784 | METHODS OF INHIBITION OF PROTEIN FUCOSYLATION IN VIVO USING FUCOSE ANALOGS - The invention provides methods and compositions for the inhibition of fucosylation of proteins, including antibodies, in vivo by administration of a fucose analog. | 2013-05-23 |
20130129785 | METHODS AND COMPOSITIONS FOR DELIVERY OF ACTIVE AGENTS - A lipid particle can include a cationic lipid. Synthesis of the cationic lipid can include a ylide-based reaction, such as a Wittig reaction or sulfur ylide reaction. In some cases, the synthesis can also include a Michael addition or a related addition reaction. | 2013-05-23 |
20130129786 | HYDROPHILIC FILTRATION DURING MANUFACTURE OF VACCINE ADJUVANTS - An improved method for the manufacture of an oil-in-water emulsion involves three procedures: (i) preparation of a preliminary emulsion; (ii) micro fluidization of the preliminary emulsion to reduce its droplet size; and (iii) filtration of the microfluidized emulsion through a hydrophilic membrane. The emulsions are useful as vaccine adjuvants. | 2013-05-23 |
20130129787 | ADHESIVE COMPLEX COACERVATES PRODUCED FROM ELECTROSTATICALLY ASSOCIATED BLOCK COPOLYMERS AND METHODS FOR MAKING AND USING THE SAME - Described herein is the synthesis of adhesive complex coacervates from electrostatically associated block copolymers, wherein the block copolymers comprise alternating polycationic and polyanionic blocks. Methods for making and the using the adhesive complex coacervates are also described herein. | 2013-05-23 |
20130129788 | Nanotubes and Compositions Thereof - The present invention is directed to implants and the modification of the surface of implants using amino acid or polypeptide functionalized rosette nanotubes. | 2013-05-23 |
20130129789 | ANTI-BACTERIAL APPLICATIONS OF POLY-N-ACETYLGLUCOSAMINE NANOFIBERS - Described herein are compositions comprising shortened fibers of poly-N-acetylglucosamine and/or a derivative thereof (“sNAG nanofibers”) and anti-bacterial applications of such compositions. The sNAG nanofibers may be formulated into compositions for the prevention and/or treatment of bacterial infections and diseases associated with such infections. Regimens employing such compositions are also described. | 2013-05-23 |
20130129790 | Adjuvant Incorporation in Immunonanotherapeutics - The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof. | 2013-05-23 |
20130129791 | PREPARATIONS OF EFFERVESCENT FORMULATIONS COMPRISING SECOND AND THIRD GENERATION CEPHALOSPORIN AND USES THEREOF - The invention relates to effervescent pharmaceutical dosage forms including cefdinir as the active agent, and their preparation. The invention also relates to effervescent formulations including ceftibuten and/or its pharmaceutically acceptable salts, hydrates, solvates, esters, amorphous and crystal forms and/or a combination thereof. The invention also relates to pharmaceutical compositions including (Z)-3-Carboxymethyl-7-(2-(2-furyl)-2-methoxyiminoacetylamino)-3-sefem-4-carboxylic acid which is named cefuroxime axetil or any pharmaceutically acceptable derivative thereof, and the use of these compositions in the treatment of bacterial infections. Lastly, the invention relates to pharmaceutical formulations including a third generation cephalosporin together with clavulanic acid and/or derivatives thereof as the active agents. | 2013-05-23 |
20130129792 | Pharmacokinetics of S-Adenosylmethionine Formulations - Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning. | 2013-05-23 |
20130129793 | MEDICAL DEVICES HAVING IMPROVED PERFORMANCE - In accordance with various aspects of the invention, implantable and insertable medical devices are provided, which contain one or more polymeric regions. In one aspect, the polymeric regions comprise (a) a block copolymer that comprises a polyaromatic block and a polyalkene block admixed with (b) a sulfonated high Tg polymer. In another aspect, the polymeric regions comprise a block copolymer that comprises (a) a sulfonated polymer block and (b) fluorinated polymer block. | 2013-05-23 |
20130129794 | Poly(Ester Amide)-Based Drug Delivery Systems - Implantable medical devices including a coating having a bioactive agent and a poly(ester amide) polymer. Methods of forming these coatings are also described. | 2013-05-23 |
20130129795 | INHIBITION AND DISPERSION OF BACTERIAL BIOFILMS WITH IMIDAZOLE-TRIAZOLE DERIVATIVES - Disclosure is provided for imidazole-triazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same. | 2013-05-23 |
20130129796 | Methods And Compositions For The Treatment Of Open And Closed Wound Spinal Cord Injuries - Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury. | 2013-05-23 |
20130129797 | POLYMERIC COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF - Described herein are polymeric compositions that comprise at least one polymer residue and at least one crosslinking moiety, wherein the polymer residue is crosslinked by the crosslinking moiety and wherein the crosslinking moiety is formed from a reaction between a boronic acid moiety and a hydroxamic acid moiety. Also, described are methods of making and using such polymeric compositions. | 2013-05-23 |
20130129798 | Extended-Release Composition Comprising a Somatostatin Derivative in Microparticles - The present invention relates to improved microparticles comprising a somatostatin analogue, a process of making said microparticles and to pharmaceutical compositions comprising the same. | 2013-05-23 |
20130129799 | TUMOR PROLIFERATION INHIBITOR CONTAINING ULTRASOUND-SENSITIVE SUBSTANCE AND METHOD FOR INHIBITING TUMOR PROLIFERATION BY USING TUMOR PROLIFERATION INHIBITOR AND LOW-INTENSITY PULSED ULTRASOUND WAVES - Provided are a tumor proliferation inhibitor and a method for inhibiting tumor proliferation both of which can be applied to a minimally invasive cancer treatment using low-intensity pulsed ultrasound. The present invention provides a tumor proliferation inhibitor containing an ultrasound-sensitive substance and an acoustic cavitation phenomenon-enhancing substance, and provides a method for inhibiting tumor proliferation that can exhibit a tumor proliferation-inhibitory effect using the tumor proliferation inhibitor in combination with low-intensity pulsed ultrasound of a degree that is used in ultrasound diagnosis, and that can be applied to a minimally invasive cancer treatment using low-intensity pulsed ultrasound. | 2013-05-23 |
20130129800 | HYALURONIC ACID BASED HYDROGEL AND USE THEREOF IN SURGERY - The present invention relates to hydrogels based on hyaluronic acid based derivatives, that are more resistant than hyaluronic acid alone towards chemical and enzymatic degradation and are endowed with a mix of chemical and mechanical properties such that they are of optimal use in several surgeries, for instance for injection in bone fractures or cavities and for the production of coatings of prostheses in orthopedic surgery, as fillers in cosmetic and maxillo-facial surgery, as anti-adhesion barrier in the prevention of postoperative adhesions in abdominal and abdominal/pelvic surgery, and in general surgery. These hydrogels can be loaded with several different kinds of compounds having pharmacological and biological activity, that are then released from the hydrogel in the site of intervention. | 2013-05-23 |
20130129801 | AQUEOUS DISPERSION COMPRISING GALACTOLIPIDS AND METHOD FOR PRODUCTION THEREOF - A method for preparing a dispersion of polar lipids in an ethanol-water mixture, the polar lipids including galactolipids. Anoil containing polar lipids including galactolipids is diluted using a first ethanol-water mixture having an ethanol concentration close to the critical polarity, wherein upon dilution the polar lipids form a lamellar liquid-crystalline phase, without first forming a hexagonal HII-phase. The invention also refers to an oil obtained by evaporating ethanol and water from the dispersion. The invention further refers to aqueous colloidal dispersions of polar lipids including galactolipids, to an oil containing polar lipids including galactolipids and to pharmaceutical, cosmetic and food compositions including such dispersions and/or oil. | 2013-05-23 |
20130129802 | GLASS FLAKES AND THEIR MANUFACTURING METHOD - A method for manufacturing glass flakes by a rotary method includes the steps of using slow fed impact millers and multiple passings through opposed jet mills to achieve a low mean thickness deviation. The glass flakes, which may be used in cosmetic formulations, have a thickness of less than | 2013-05-23 |
20130129803 | COSMETIC MATERIAL COMPRISING A SAPPAN WOOD EXTRACT ON A CLAY SUBSTRATE - A material including an organic dye of vegetable origin on an inorganic substrate, characterized in that the organic dye is an extract of sappan wood and in that the inorganic substrate is a clay which is a continuous sheet crystallized silicate. Also, a cosmetic composition containing this material, and the uses thereof. | 2013-05-23 |
20130129804 | BAIT FORMULATIONS FOR CONTROLLING SLUGS AND SNAILS - The invention relates to bait formulations comprising at least one iron salt, at least one component selected from among methyl glycine-N,N-diacetic acid, glutamine-N,N-diacetic acid, and the alkali metal, alkaline earth metal and ammonium salts thereof; and at least one starch-containing component. The invention also relates to the use of said bait formulation for controlling terrestrial slugs and snails and to a method for controlling terrestrial slugs and snails using the bait formulation of the invention. | 2013-05-23 |
20130129805 | COMPOSITION WITH STERILIZING ACTIVITY AGAINST BACTERIA, FUNGUS AND VIRUSES, APPLICATION THEREOF AND METHOD FOR PREPARATION THEREOF - Disclosed herein are an anti-bacterial, anti-fungal and anti-viral composition with excellent sterilizing power, deodorization and adhesion activity, an application thereof, and a method for preparing the same. The composition with sterilizing activity against bacteria, fungus and virus comprises colloidal silver particles in an amount of from 11 wt % to 15 wt %, titanium dioxide nanoparticles in an amount of from 18 wt % to 25 wt %, a dispersion stabilizer in an amount of from 0.01 wt % to 10 wt %, a binder in an amount of from 0.1 wt % to 4 wt %, and a balance of water in an amount required to form 100 wt %. | 2013-05-23 |
20130129806 | HARD COATING WITH ERYTHRITOL - The present invention relates to a coated product comprising a core and a hard coating surrounding the core, wherein the hard coating is composed of at least one coating layer, which comprises erythritol, maltodextrin and one or more crystallization modifiers, preferably carrageenan. | 2013-05-23 |
20130129807 | COLLAGEN-BASED IMPLANTS FOR SUSTAINED DELIVERY OF DRUGS - The disclosure provides collagen-based constructs for use in drug delivery. | 2013-05-23 |
20130129808 | MEDICAL PRODUCT CONTAINING ACTIVE COMPONENT OF PROPOLIS OR GRAPEFRUIT SEED EXTRACT AND MANUFACTURING METHOD THEREOF - A medical product containing either an active ingredient of propolis which is a natural antibiotic or a grapefruit seed extract, and a manufacturing method thereof are provided. The medical product is impregnated with a solution of CAPE (caffeic acid phenethyl ester) or pinocembrin, which is an active ingredient of propolis having antibacterial effects, to increase the antibacterial activity of the medical product due to antibacterial compounds contained in the active component, or the medical product is impregnated with a solution of a grapefruit seed extract such that the extract can exhibit antibacterial activity in the medical product. | 2013-05-23 |
20130129809 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CANCER BY TARGETING AND INHIBITING CANCER STEM CELLS - The invention relates to compositions and methods for treating cancer comprising administering to a subject in need a pharmaceutically effective dose of a cancer stem cell inhibitor, methods of inhibiting the growth of cancer stem cells or tumor initiating cell comprising administering to a subject in need a pharmaceutically effective dose of a cancer stem cell inhibitor, and methods of enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells comprising administering to a subject in need a pharmaceutically effective dose of a chemotherapeutic drug and a pharmaceutically effective dose of a cancer stem cell inhibitor. | 2013-05-23 |
20130129810 | IRON OXIDE NANOPARTICLES FOR USE IN TREATING NON-INFECTIOUS INFLAMMATORY DISORDERS - In accordance with the present disclosure there are provided iron oxide nanoparticles for use in the treatment of non-infectious inflammatory disorders. Also provided by the present disclosure is a method of treatment of non-infectious inflammatory disorders making use of such particles, pharmaceutical compositions and kits comprising such particles | 2013-05-23 |
20130129811 | CATIONIC LIPID - The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) | 2013-05-23 |
20130129812 | NOVEL COMPOSITIONS AND METHODS FOR TREATING CANCER - Provided herein are methods and compositions inter alia for treating diseases, including hyperproliferative diseases, migraine headaches, and depression. | 2013-05-23 |
20130129813 | TARGETED DELIVERY USING TISSUE-SPECIFIC PEPTIDOMIMETIC LIGANDS - Compositions and methods for tissue-specific targeted delivery of therapeutic agents through the use of tissue-specific peptidomimetic ligands are disclosed herein. The ligand comprises a composition of formula A-scaffold-A′ and one or more hydrophobic anchors covalently linked to the scaffold. The A and A′ compounds linked to the scaffold comprise monovalent peptidomimetic compounds wherein each monovalent peptidomimetic compound is selected from the group consisting of fragments IKs, GKs, IDs, GSs, GTs, VSs, TKs, KTs, ARs, KIs, KEs, AEs, GRs, YSs, IRs, and morpholino. | 2013-05-23 |
20130129814 | Regional Delivery Of Therapeutic Agents For The Treatment Of Vascular Diseases - The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well. | 2013-05-23 |
20130129815 | LIPOSOMAL FORMULATION FOR ORAL ADMINISTRATION OF GLUTATHIONE (REDUCED) VIA GEL CAPSULE - The invention is a composition administrable orally to provide systemic glutathione (reduced) and a method for providing systemic glutathione by oral administration of glutathione (reduced) in a liposome encapsulation in a gel cap. The administration of a therapeutically effective amount of oral liposomal glutathione (reduced) results in improvement of symptoms in disease states related to glutathione deficiency such as Parkinson's disease and cystic fibrosis. Compounds enhancing the effect of the liposomal glutathione are contemplated such as Selenium, EDTA, carbidopa, and levodopa. | 2013-05-23 |
20130129816 | THERAPEUTIC COMPOSITION WITH ENHANCED ENDOTHELIUM TARGETING - A composition that includes nanoparticles with binding affinity for platelets, and methods for using this composition to treat vascular disease are disclosed. | 2013-05-23 |
20130129817 | METHOD OF TREATING MALIGNANT SOLID TUMORS - This invention is directed to methods of treating solid tumor cancers, particularly refractory cancers by administration of a drug capable of inhibiting mTOR and/or inhibiting an efflux pump and/or inhibiting HIF-1α and VEGF, the drug in particular being selected from the group consisting of sirolimus, everolimus, zotarolimus, tacrolimus, iolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, novolimus, 40-O-(3-hydroxypropyl), 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin and 40-O-tetrazolylrapamycin, the drug being administered along with a chemotherapeutic agent and/or radiation therapy. | 2013-05-23 |
20130129818 | NATURAL COMBINATION HORMONE REPLACEMENT FORMULATIONS AND THERAPIES - Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone. | 2013-05-23 |
20130129819 | Pharmaceutical Formulations Containing An SGLT2 Inhibitor - Pharmaceutical formulations are provided which are in the form of capsules or tablets for oral use and which include a medicament dapagliflozin or its propylene glycol hydrate | 2013-05-23 |
20130129820 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE - Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R | 2013-05-23 |
20130129821 | Ubiquinol and Alpha Lipoic Acid Compositions - The present invention is directed to compositions and methods of delivery of CoQ that is reduced in the presence of lipoic acid and, optionally a fatty acid and/or optionally in a monoterpene. The compositions that include the reduced CoQ can be formulated in soft gel capsules. | 2013-05-23 |
20130129822 | LIQUID-FILLED HARD GEL CAPSULE PHARMACEUTICAL FORMULATIONS - Embodiments of liquid-filled hard gel capsule pharmaceutical formulations comprise a non-emulsified mixture, wherein the non-emulsified mixture comprises about 0.1 to about 5% by weight of at least one active pharmaceutical ingredient, about 50 to about 95% by weight medium chain triglycerides, and about 5 to about 25% by weight medium chain mono/diglycerides, wherein the medium chain triglycerides and medium chain mono/diglycerides are present at a ratio by weight of from about 10:1 to about 5:1. | 2013-05-23 |
20130129823 | PHARMACEUTICAL COMPOSITIONS FOR GLUCOCORTICOID REPLACEMENT THERAPY - The invention relates to glucocorticoid replacement therapy and provides pharmaceutical compositions and kits designed to deliver one or more glucocorticoids to a subject in need thereon in a manner that results in serum levels of the glucocorticoid that essentially mimic that of a healthy subject for a clinically relevant period of time. The pharmaceutical compositions and kits are prepared in such a way that a first part of one or more glucocorticoids is substantially immediately released and a second part of one or more glucocorticoids is released over an extended period of time of at least about 8 hours. The invention also relates to a method for treating diseases requiring glucocorticoid treatment such as in subjects having a glucocorticoid deficiency disorder. | 2013-05-23 |
20130129824 | Solid Drug Tablets for Implantable Drug Delivery Devices - A drug dosage form is provided in the form of a solid tablet which is greater than 50% by weight the local anesthetic agent. The local anesthetic agent may be selected from the group consisting of an aminoamide, an aminoester, and a combination thereof. The drug tablet may be in the form of a mini-tablet which is greater than 70 wt % drug, with the balance being excipient. For example, the anesethetic agent may include lidocaine, in a salt or base form, combined with binder and lubricant excipients. Implantable drug delivery devices including the tablets are also provided, e.g., one or more of the drug tablets may be contained in a biocompatible housing. The drug tablets may be substantially cylindrical with flat end faces, and the device may have from 10 to 100 drug tablets aligned in the housing with the flat end faces of adjacent tablets abutting one another. | 2013-05-23 |
20130129825 | DIVERSION-RESISTANT MICROGRANULES AND MICROTABLETS - The invention relates to the use of an oral dosage form based on microgranules and/or microtablets to reduce the abusive use of at least one active principle contained therein. The aim of the invention is to prevent the diversion of an oral dosage form based on microgranules and/or microtablets containing at least one active principle capable of causing a dependency, a gelling agent, and a gelling activator. The gelling agent and the activator are only brought into contact with each other in the event of diversion by crushing. Said judiciously selected pair of excipients confers a viscosity to the formulation, such that said formulation cannot be administered by injection or does not release the active principle rapidly by forming a gel when it comes into contact with the mucous membrane if nasally administered. | 2013-05-23 |
20130129827 | EXTENDED RELEASE PHARMACEUTICAL COMPOSITIONS OF PALIPERIDONE AND PROCESSES OF PREPARATION THEREOF - The present invention relates to extended release pharmaceutical compositions of paliperidone and process of preparation thereof. | 2013-05-23 |
20130129828 | COMPOSITIONS AND METHODS FOR DELIVERY OF POORLY SOLUBLE DRUGS - Described herein are compositions comprising particles of poorly soluble drugs encapsulated by stabilizers. Further described are pharmaceutical compositions comprising such encapsulated compositions. Also described are methods of making such encapsulated particle compositions, and methods of making the corresponding pharmaceutical compositions. The encapsulated particle compositions described herein allow poorly soluble drugs to be administered with good bioavailability by routes that are non-invasive to patients, such as by oral administration. | 2013-05-23 |
20130129829 | Encapsulation and Controlled Release of Small Molecules for Intracellular Delivery Using Thermally Responsive Nanocapsules - In accordance with certain embodiments of the present disclosure, a method for intracellular delivery of small molecules is provided. The method includes encapsulation of small molecules in a thermally responsive nanocapsule by decreasing the temperature of the nanocapsule to increase the permeability of the nanocapsule and allowing the small molecules to be suck into or diffuse into the nanocapsule. The nanocapsule is delivered into a cell by increasing the temperature of the nanocapsule. The small molecules are released from the nanocapsule into the cell in a controllable manner by cooling and heating treatments. | 2013-05-23 |
20130129830 | Polymer Protein Microparticles - Microparticles containing a core of therapeutic protein and a cortex of a biocompatible and biodegradable polymer, and methods of making and using the microparticles are provided. The extended release of a therapeutic protein from the microparticles in a physiological solution is demonstrated over an extended period of time. | 2013-05-23 |
20130129831 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 2013-05-23 |
20130129832 | COGNITIVE IMPAIRMENT AMELIORANT - A cognitive impairment ameliorant is provided that is useful for the prevention or treatment of cognitive impairment, and particularly Alzheimer's disease. The cognitive impairment ameliorant contains royal jelly as an active ingredient thereof. | 2013-05-23 |
20130129833 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 2013-05-23 |
20130129834 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 2013-05-23 |
20130129835 | CROSSLINKED HYALURONIC ACID-COLLAGEN GELS FOR IMPROVING TISSUE GRAFT VIABILITY AND SOFT TISSUE AUGMENTATION - Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component. | 2013-05-23 |
20130129836 | PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME - Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane. | 2013-05-23 |
20130129837 | COMPOSITIONS FOR IMPROVEMENT OF WOUND HEALING - This invention relates to aqueous solutions of reactive chlorine compounds having the empirical formulae H | 2013-05-23 |
20130129838 | NUTRITIONAL COMPOSITIONS AND METHODS FOR OPTIMIZING DIETARY ACID-BASE POTENTIAL - Nutritional compositions having the potential to reduce metabolic acid load and methods of making and using the nutritional compositions are provided. In an embodiment, the present disclosure provides methods of selecting and administering nutritional compositions to patients. The methods may include modifications to calculating a metabolic acid potential of a nutritional composition, calculating a base content of a nutritional composition and subtracting the base content from the acid content to determine a potential renal acid load (“PRAL”) value. The present disclosure also provides computer implemented processes for predicting PRAL values. | 2013-05-23 |
20130129839 | FUNGICIDAL PYRAZOLES AND THEIR MIXTURES - Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1, N-oxides, and salts thereof, | 2013-05-23 |
20130129840 | COMBINATION THERAPY USING A RUTHENIUM COMPLEX - A combination therapy is disclosed for treating cancer. The method comprises administering to a cancer patient a therapeutically effective amount of trans-[tetrachlorobis(1H-indazole)ruthenate(III)] or a pharmaceutically acceptable salt thereof, and administering to the patient a therapeutically effective amount of one or more other anti-cancer agents as disclosed herein. | 2013-05-23 |
20130129841 | THERAPEUTIC COMBINATION COMPRISING A PARP-1 INHIBITOR AND AN ANTI-NEOPLASTIC AGENT - The present invention provides a therapeutic combination comprising (a) a compound of formula (I) as set forth in the specification and (b) one or more antineoplastic agents selected from the group consisting of an alkylating or alkylating-like agent, an antimetabolite agent, a topoisomerase I inhibitor, a topoisomerase II inhibitor, an antimitotic agent and radiation wherein the active ingredients are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate thereof. | 2013-05-23 |
20130129842 | COMPOSITION AND METHOD FOR TREATMENT OF INSECT BITES - A composition for treating wounds of the skin, such as those caused by the bites of small insects or jellyfish, includes a wax or resin, an emulsifier, and ammonium hydroxide. The composition is applied to the skin in a thin layer, and when it dries, it forms a thin, protective film over the wound. Application of the composition has been found to provide temporary and immediate relief of pain and/or itching. The protective film shields the wound, and therefore aids in healing. The composition can be made of any of a variety of waxes or resins, and the emulsion can be formed with long-chain alcohol or fatty acid soaps, such as oleic acid or triethanolamine. | 2013-05-23 |
20130129843 | Microbiocidal Treatment Of Edible Fruits And Vegetables - Methods of controlling bacterial, yeast, and/or mold contamination of edible fruits or vegetables comprise applying thereto an aqueous microbiocidal composition formed from water and (A) at least one component selected from (I) a solid-state microbiocidal compound having at least one bromine atom per molecule; (II) an aqueous solution/slurry of a compound of (I); (III) a concentrated aqueous composition having an active bromine content of at least 50,000 ppm derived from water and (i) BrCl or BrCl and Br | 2013-05-23 |
20130129844 | Preservative-Free Composition for Topical Use Including Hyaluronic Acid - The present invention relates to a sterile and/or decontaminated composition for topical use, including hyaluronic acid at a concentration of greater than or equal to 0.1 wt % relative to the total weight of the composition, at least one skin wound healing agent, optionally at least one plant extract, and at least one solvent. The invention also relates to a unit including such a composition, to a method for preparing such a composition, and to the uses thereof. | 2013-05-23 |
20130129845 | SCREENING METHOD FOR CHRONIC INFLAMMATION INHIBITORS OR CANCER METASTASIS INHIBITORS USING INHIBITION OF BINDING BETWEEN EMMPRIN AND S100A9 AS INDEX - The invention provides a screening method for chronic inflammation inhibitors or cancer metastasis inhibitors wherein, when a candidate substance as a chronic inflammation inhibitor or cancer metastasis inhibitor significantly inhibits binding between EMMPRIN and S100A9 or S100A8/A9, the candidate substance is evaluated as significantly suppressing chronic inflammation or cancer metastasis. | 2013-05-23 |
20130129846 | Ginger Extract for Inhibiting the Fat-Storage Function of Adipocytes and a Medication Thereof - In the present invention, a ginger extract for inhibiting the fat-store function of adipocytes and a medication thereof is disclosed, wherein the ginger extract is obtained form | 2013-05-23 |
20130129847 | Composition and Method for Reducing Post-Prandial Blood Glucose - A nutritional intervention composition for reducing post-prandial blood glucose levels in humans, including between about 0.1 mg and about 10 mg of a proteinase inhibitor that is administered prior to the meal. The composition is effective for treating or ameliorating the effects of hyperglycemia and Type II diabetes. The composition also is effective in combating obesity. The proteinase inhibitor is preferably isolated from plant material, such as potatoes, soy, and beans. Potato proteinase inhibitor II and soybean Bowman-Birk inhibitor are included in the group of effective proteinase inhibitors. | 2013-05-23 |
20130129848 | INSECT-REPELLENT OR INSECTICIDAL COMPOSITION COMPRISING EXTRACT OR FRACTION OF PHELLODENDRON AMURENSE AS AN EFFECTIVE INGREDIENT FOR CONSERVATION OF CULTURAL HERITAGE - An insect-repellent and insecticidal composition comprising extract or fraction of | 2013-05-23 |
20130129849 | METHOD OF EXTERNAL SKIN APPLICATION OF COMPOSITION CONTAINING RED PINE ROOT EXTRACT - The present invention relates to a composition for skin external application containing a pine root extract. More specifically, the composition for skin external application according to the present invention contains, as an active ingredient, a pine root extract which shows various effects, including eliminating free radicals, protecting the cell membrane from damage by UV radiation, inhibiting the production of reactive oxygen species caused by UV radiation, inhibiting the reduction in the expression of superoxide dismutase (SOD) and catalase caused by UV radiation, stimulating the production of HSP70 to protect cells, inhibiting MMP-2 biosynthesis caused by UV radiation, inducing the expression of SIRT1 gene that restores DNA damage, and inducing the expression of LMNA1 gene that maintains the structure of the nuclear membrane. Ultimately, the composition of the present invention prevents skin aging. | 2013-05-23 |
20130129850 | SURFACE TREATMENT OF RUBBER USING LOW PRESSURE PLASMA - A method of treating a surface of an object comprising a rubber material and in particular a bladder for use in a process for making a vehicle tyre. The method comprises subjecting the surface to a gas at a low pressure at which the gas is susceptible of forming plasma, and causing the gas to form plasma. In order to obtain repellent properties of the surface of the rubber material fluorine gas such as tetrafluormethane or hexafluorethane is used. Preferably the treatment is performed until there is obtained a surface layer of the rubber material with properties modified by the treatment having an expected lifetime corresponding to the expected lifetime of the object. | 2013-05-23 |
20130129851 | DEVICE FOR MAKING TEXTURED PORTIONS OF FOOD PRODUCTS - A device that makes it possible to produce end products having a textured aspect identical to that of the initial food product introduced into the pump, and particularly in the case of meat, keeping the fibrous aspect of the initial pieces of meat. The device according to the invention may be used for producing portions from any type of food product in pieces, such as meat in muscle, filleted fish, and vegetables in pieces such as carrots for example. | 2013-05-23 |
20130129852 | APPARATUS FOR FORMING SLANT, LINEAR EASY-TO-TEAR PORTIONS ON LONG PLASTIC FILM - An apparatus for periodically forming slant, linear easy-to-tear portions on a long plastic film, comprising a hard roll on which the long plastic film passes, pluralities of pattern rolls each having a slant, linear stamp means on a rolling surface, a motor-driven shaft to which the pattern rolls are fixed, and a mechanism for pushing the pattern rolls toward the hard roll, the movement of the pressure rolls toward the hard roll causing the pattern projections of the stamp means to be pressed onto the plastic film on the hard roll, thereby periodically forming the slant, linear easy-to-tear portions on the plastic film. | 2013-05-23 |
20130129853 | MOLD SYSTEM FOR FORMING MULTILEVEL BLOCKS - A mold system for forming a multilevel block is disclosed which comprises a multilevel mold box insert for forming a multilevel block, a mold box frame adapted for receiving therein the multilevel mold box insert, a multilevel plunger assembly, and a press head plate adapted for receiving thereon the multilevel plunger assembly. | 2013-05-23 |
20130129854 | EQUIPMENT FOR DRAWING A FILM MADE OF SYNTHETIC MATERIAL - The invention relates to equipment ( | 2013-05-23 |
20130129855 | VIBRATING MACHINE FOR PRODUCING MOLDED BODIES BY MEANS OF COMPACTING - A vibrating machine for producing a molded body by compacting a granular raw mixture includes an oscillatable vibrating table configured to receive a molding box. A clamping device is produced by at least two clamping closures, each including: a pivot bracket having a lower end being pivotally mounted on the vibrating table and an upper end including a cranking which is directed outward; a double-acting hydraulic pivot cylinder pivotally mounted on the vibrating table; a two-armed rocker arm pivotally connected to the pivot bracket and including an inner part that cooperates with the molding box and an outer part that cooperates with the hydraulic pivot cylinder; and a compression spring disposed between the cranking and the outer part of the rocker arm such that the rocker arm releases from a position closing the respective clamping closure upon a pressure in the hydraulic pivot cylinder being relieved. | 2013-05-23 |
20130129856 | CLOSURE ASSEMBLY, WITH A MULTI-ROD DRIVE, FOR THE INJECTION MOULDING OF PLASTIC MATERIAL - A closure assembly, of the type with a multi-rod drive, for the injection moulding of plastic material is described. The closure assembly has a plurality of closing rods and a driving plate, wherein the driving plate is adapted to move between an open position and a closed position. The closure assembly also has disconnecting and fixing means associated with each closing rod for disconnecting it from the driving plate, independently from the other closing rods, and to firmly fix it, once disconnected, on a side of the mould. | 2013-05-23 |
20130129857 | MOULD FOR INJECTION-MOULDING OF PLASTIC PARTS - Moulds for injection molding of plastic parts comprising a die and a punch which define, in the closed mould condition, a cavity intended to receive plastic material injected by a press are provided. The punch may comprise a central element and a pair of first lateral elements arranged on longitudinally opposite sides relative to the central element, each of the first lateral elements being slidably guided along a respective inclined lateral surface of the central element to be displaced between a moulding position and an ejection position. | 2013-05-23 |
20130129858 | DIE CLAMPING DEVICE FOR INJECTION MOLDING MACHINE - Breakage of the actuator moving the movable platen in the clamping device of an injection moulder is prevented. The clamping device includes a movable platen shifting device increasing and decreasing a horizontal distance between the movable platen ( | 2013-05-23 |
20130129859 | DOSING PROTOCOLS FOR INCREASING PROTEIN SYNTHESIS IN AN ACTIVE INDIVIDUAL - Methods utilizing either bite-size nutritional products or large individual protein doses for customized protein intake are provided. In a general embodiment, the present disclosure provides a method of providing nutrition to an athlete. The method comprises providing a protein-based regimen that can alter the availability of amino acids to the athlete without providing different types of fast or slow type proteins (e.g., whey or casein, respectively) and providing personal guidelines for consuming protein-based products that comprise the protein-based regimen while exercising. | 2013-05-23 |
20130129860 | NUTRITIONAL COMPOSITIONS COMPRISING FRUIT FLAKES CONTAINING DOCOSAHEXAENOIC ACID - Nutritional compositions and methods for making and using said nutritional compositions are provided. In a general embodiment, the present disclosure provides a nutritional composition that has fruit flakes that include docosahexaenoic acid. The docosahexaenoic acid can be incorporated directly in the fruit flakes. | 2013-05-23 |
20130129861 | PEARLESCENT PIGMENT SURFACE TREATMENT FOR CHEWABLE CONFECTIONERY AND METHODS OF MAKING THE SAME - Disclosed herein are particulate coating compositions comprising a powdered carrier and a pearlescent pigment. Also disclosed herein are pearlescent, coated chewing gum compositions comprising the particulate coating composition and methods for making the pearlescent coated chewing gum compositions. | 2013-05-23 |
20130129862 | BARLEY LIPOXYGENASE 1 GENE, METHOD OF SELECTING BARLEY VARIETY, MATERIAL OF MALT ALCOHOLIC DRINKS AND PROCESS FOR PRODUCING MALT ALCOHOLIC DRINK - A selection method for barley lipoxygenase-1 deficient barley, comprising a step of distinguishing the barley lipoxygenase-1 deficient barley by whether or not the guanine at the splicing donor site of the 5th intron of the barley lipoxygenase-1 gene is mutated to a different base; and a method for production of malt alcoholic beverages using a material for malt alcoholic beverages derived from barley obtained by the selection method. | 2013-05-23 |
20130129863 | Lactic Acid-Fermented Egg Having Reduced Egg Protein Antigenicity Through Addition Of Sodium Citrate, Heating Treatment, And Lactic Acid Fermentation, And Method For Preparing Same - The present invention relates to a lactic acid-fermented egg having reduced egg protein antigenicity and improved organoleptic quality through the addition of sodium citrate, heating treatment, and lactic acid bacteria fermentation, and more specifically, to a lactic acid-fermented egg having reduced egg protein antigenicity, which comprises a series of steps of adding to whole egg liquid a fixed amount of filtered water, sugar, and sodium citrate, heating treating and lactic acid-fermenting same, and a method for preparing same. The present invention reduces the antigenicity of ovomucoid and ovalbumin, which are allergy inducing factors existing inside an egg, has excellent solubility, and excellent organoleptic quality. | 2013-05-23 |
20130129864 | RYE FLOUR IMITATION - The present invention relates to the field of food production, in particular the production and provision of a gluten-free baking mix for the preparation of gluten-free baked goods and bread. | 2013-05-23 |
20130129865 | VACUUM INFUSION FOR THE INCLUSION OF A SUPPLEMENT INTO FOOD PRODUCTS - An improved method of vacuum infusion of a supplement in a porous food product comprising treating a porous food product having a majority pores of within a certain diameter size range with a supplement dispersed in a carrier wherein the supplement comprises particles the majority of which have a size range which is less than the pore diameter size range, said method performed under suitable conditions and for a suitable tone to achieve infusion of the supplement into the food product, the improvement comprising higher levels of supplement incorporation than with other supplement particle sizes. | 2013-05-23 |
20130129866 | Caffeinated Creamer - Additives for beverages may comprise caffeine, vitamins and/or other supplements. The additives may be for hot beverages such as coffee or tea. An additive for a beverage may consist essentially of a creamer and caffeine. The creamer may be a liquid creamer or a solid creamer. An additive may comprise a caffeine concentration from 2 milligram caffeine per milliliter of creamer to 15 milligrams caffeine per milliliter of creamer, for example. | 2013-05-23 |
20130129867 | AGGLOMERATED PROTEIN COMPOSITION - The present invention relates to compositions and methods for producing an agglomerated protein composition comprising at least one acid soluble protein. | 2013-05-23 |
20130129868 | Protein Precipitate Comprising Minerals and Method for the Manufacture Thereof - Edible precipitate is disclosed binding one or more minerals that are stable in acidic aqueous systems. The precipitate may be utilized in acidic food products. The precipitate comprises at least one mineral and a layer around the at least one mineral wherein the layer comprises protein precipitate. Methods of producing the precipitate are also disclosed. | 2013-05-23 |
20130129869 | COMPOSITIONS COMPRISING A SHELF-LIFE STABILITY COMPONENT - Compositions that include a shelf-life stability component are provided. In some instances, the compositions are ingestible compositions which include the shelf-life stability component and an ingestible component. Aspects of the invention further include methods of making and using the compositions. | 2013-05-23 |
20130129870 | METHOD AND APPARATUS FOR CARTRIDGE-BASED CARBONATION OF BEVERAGES - Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage. A gas source can be provided in a cartridge which is used to generate gas that is dissolved into the precursor liquid. A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid to form a beverage. The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making sparkling beverages, e.g., in the consumer's home. | 2013-05-23 |
20130129871 | BEVERAGE SUBSTANCE CARTRIDGE, WATER FILLING APPARATUS, BEVERAGE PRODUCING EQUIPMENT, BEVERAGE PRODUCING SYSTEM AND BEVERAGE PRODUCING METHOD - The invention provides a beverage substance cartridge, a tea filtering apparatus, a beverage producing equipment, a beverage producing system and a beverage producing method to efficiently solve the problem that a tea brewing equipment of the present technology has problems like slow tea leaf extraction, long tea drinker waiting time, low tea water temperature, bad tea water taste, etc. The water filling apparatus of the beverage producing equipment fills hot water into the bottom of the beverage substance cartridge near the side wall of the cartridge body, and forms vortex in the beverage substance cartridge which speeds up extraction efficiently. Furthermore, inside convex edges are set at the side wall of the beverage cartridge and hot water temperature is high enough to strengthen extraction effects and then realize rapid brewing effects in the tea brewing equipment. The beverage producing equipment adopting the invention could be widely applied in offices and homes. | 2013-05-23 |
20130129872 | PORTION CAPSULE HAVING AN IDENTIFIER - A portion capsule for producing a beverage includes a base element having a cavity in which a beverage raw material is provided and which is closed by a membrane fastened to the base element. | 2013-05-23 |
20130129873 | PROCESS FOR FABRICATING LEAF TEA PRODUCTS - Disclosed is a process for manufacturing a fabricated leaf tea product. The process comprises the steps of: (i) providing a concentrated liquid tea composition; (ii) providing a base leaf tea; (iii) combining the concentrated liquid tea composition with the base leaf tea to form a tea mixture having a total soluble solids content of at least 50% by dry weight of the mixture; and (iv) drying the tea mixture. At least 20% by weight of the base leaf tea has a particle size of +16 mesh and/or the tea mixture is sorted according to particle size to yield a fraction wherein at least 20% by weight of the fraction has a particle size of +16 mesh; and the time between forming the tea mixture (step iii) and drying (step iv) is at least 5 minutes. | 2013-05-23 |
20130129874 | PACKAGE WITH CLOSURE, APERTURE, AND INSERT - Described are packages useful for food and non-food items, wherein the packages include a closure, an aperture located on the closure, and an insert that covers the aperture; the package can optionally be pressurized and certain embodiments can be designed to contain a dough product for refrigerated storage. | 2013-05-23 |
20130129875 | COOKING AID - A cooking aid comprising a sheet of flexible burn resistant material and a composition disposed on one face of the sheet, the composition comprising a mixture of vegetable or animal oil with a melting point below 20° C., vegetable or animal fat with a melting point above 20° C., and one or more herbs, spices and flavour enhancers. | 2013-05-23 |
20130129876 | Beverage Substance Cartridge, Identifying Apparatus, Beverage Producing Equipment, Beverage Producing System and Beverage Producing Method - The invention provides a beverage substance cartridge, an identifying apparatus, a beverage producing equipment, a beverage producing system and a beverage producing method which could supply water automatically instead of manual work, identify information about beverage substance likewise such as variety and years of tea leaf, and furthermore, take different brewing methods targeting at different beverage substances (e.g. tea leaf) according to identified information in collaboration with pre-stored beverage brewing parameters to make sure every beverage substance could be brewed according to the perfect method, so the advantage of beverage substance will be given into full play. The beverage producing equipment which adopts the invention could yield brewing results accomplished by specialists and furthermore be widely used in offices and homes. | 2013-05-23 |
20130129877 | REMOVAL OF PESTICIDE RESIDUES IN FOOD BY IONIZING RADIATION - The present disclosure relates to a process for removal of pesticide residues from aqueous solutions and food products by ionizing radiation. Standard pesticides concentrations recognized by international organizations as maximum residues limit (MRLs) were used as the targeted concentrations in both aqueous solutions and food products. Commercially known pesticides and recommended irradiation doses by International Atomic Energy Agency (IAEA) were selected for this investigation. Aqueous solutions and food products fortified with pesticide residues were subjected to selected doses of ionizing radiation. Radiation-induced removal of pesticide residues is generally greater in aqueous solutions than in food products. Ionizing radiation can reduce the residues of pirimiphos-methyl in potatoes, grapes and dates; malathion and cypermethrin in grapes to below MRLs at the recommended irradiation doses. | 2013-05-23 |
20130129878 | GREEN COLORING OF TABLE OLIVES WITH CHLOROPHYLL COMPOUNDS - A process for coloring treated and untreated green olives by using chlorophyll, chlorophyllin, and copper chlorophyllin salts is presented. The process includes soaking salt out of the green olives in sodium chloride of density from about 0% to about 7%. The process also includes sinking the green olives into a first fluid solution holding sodium hydroxide and other metal hydroxyl groups from about 0% to about 3.5%, chlorophyll chlorophyllin salts and copper chlorophyllin salts, in a ratio of olive liquid from about 0.45 to about 4. The process then includes leaving the green olives in the first fluid solution from about 1 hours to about 72 hours, removing the green olives from the first fluid solution, washing the green olives with water, and sinking the green olives into a second fluid solution holding an acid until a PH of the green olives becomes less than about 4.6. | 2013-05-23 |
20130129879 | NEUTRAL BEVERAGE AND OTHER COMPOSITIONS AND PROCESS FOR MAKING SAME - The present invention relates to the use of at least one acid soluble vegetable protein in a neutral beverage application. The neutral beverage application includes a soymilk. The current application produces a soymilk having a bland taste and a whiteness index close to cow's milk. | 2013-05-23 |
20130129880 | BANANA TREATMENTS - There is provided a method for treating bananas comprising contacting the bananas with a liquid composition comprising a cyclopropene molecular encapsulation agent complex, wherein the duration of contact is from 1 second to 4 minutes. | 2013-05-23 |
20130129881 | Carbohydrate Rich Food Composition Containing Cyclodextrin And Method of Making The Same - A food composition including a carbohydrate rich food base and cyclodextrin mixed with the food base to form the food composition having a volume increase of 15 percent or greater relative to a comparable control composition without the cyclodextrin. In certain instances, the food composition is a fruit juice, puree, or jam, starchy/carbohydrate rich food syrup and powders such as dried potatoes, and cocoa, dairy products like plain and non-fat yogurt, and simple carbohydrates like maltodextrins, starch, or sugar | 2013-05-23 |
20130129882 | METHOD FOR ENHANCING POST-PROCESSING CONTENT OF BENEFICIAL COMPOUNDS IN BEVERAGES NATURALLY CONTAINING SAME - A process for enhancing polyphenolics content of beverages brewed from polyphenolic containing, processed beverage substrate by pre-soaking substrate (coffee beans, for example) before roasting and then quenching the substrate after processing with the liquid in which the substrate was first “pre-soaked.” Beverages produced from the treated substrate exhibit substantially increased polyphenolics content, when compared to conventionally processed beverage substrate of the same nature and processing. | 2013-05-23 |
20130129883 | Packaging and Process for Cooking Food Products in an Oven - An improved packaging and process for cooking food products in an oven is disclosed, the packaging comprising a lower panel not containing any perforations; an upper panel containing a plurality of perforations, and where the upper panel and lower panel are coupled to define at least one food compartment to store at least one food product. The plurality of perforations allows for cooking of the food in an oven when the food packaging is placed in the oven with the lower panel facing downward. The present invention allows the food product to be easily transported, properly cooked in an oven to an optional consistency and quality, and provided to the consumer with minimal costs and efforts. | 2013-05-23 |
20130129884 | BEVERAGE BREWING SYSTEM AND METHOD OF USE - An apparatus for brewing a beverage, which includes an elongated member having a plurality of disks stacked along an axis of the elongated member; a filter having at least one slot and adapted to fit over the plurality of disks; and an elongated housing member having first and second slots on opposite sides of the elongated housing member, wherein the elongated housing member is adapted to fit over the filter. | 2013-05-23 |