19th week of 2012 patent applcation highlights part 45 |
Patent application number | Title | Published |
20120115119 | Artificial Lung - The invention relates to an artificial lung for simulating the stress by a user when testing a breathing apparatus, particularly a compressed air breathing apparatus, comprising a housing, which surrounds a pulmonary space for the breathing air and has a connection for supplying the breathing air to the breathing apparatus. In order to be able to variably control the volume flow for generating a certain respiration curve, the housing ( | 2012-05-10 |
20120115120 | DEVICE FOR TELLING OR LEARNING TO TELL THE TIME - A kit that may be assembled to produce a device for telling the time or learning to tell the time, more particularly to a device to assist children to learn how to tell the time by reading conventional analog clock. The kit comprises annular members selected from the group consisting of blank annular members, annular members with markings around the periphery dividing the periphery into a plurality of arcs, and mixtures thereof; and a member having a circular transparent face, a peripheral side wall and an optionally removable central boss on which elongated members extending towards the periphery may be mounted. | 2012-05-10 |
20120115121 | METHOD AND SYSTEM FOR TOUCH SCREEN BASED SOFTWARE GAME APPLICATIONS FOR INFANT USERS - Methods and systems for providing age appropriate activities to infant users. The age of the infant user is first determined and, based on the age, activities are presented to the infant user. Younger infant users will be presented with simpler and easier to understand activities requiring less manual dexterity and comprehension skills while older infant users will be presented with more complex tasks which may require more involved comprehension skills. These activities are presented by way of a touch screen user interface for ease of use by the infant user. Also disclosed are methods and systems for exposing the infant user to a variety of languages at an early age. These methods and systems may be incorporated as activities for older infant users. | 2012-05-10 |
20120115122 | DYNAMIC ROLE-BASED INSTRUCTIONAL SYMBIONT FOR SOFTWARE APPLICATION INSTRUCTIONAL SUPPORT - The disclosure provides a computer-based learning system that minimizes the “distance” between applications (for which instructions are provided) and the instructions themselves. That is, the instructional material provided is dynamically integrated with a “state” of one or more applications, which constantly change as a user interacts with the application. Further, the instructional information is visually presented within a common screen, window, or focus region as the application, in a minimally intrusive manner. For example, the instruction window can be an overlay that is designed to “hide from” or to avoid obscuring application content of particular interest to a user. Various techniques can be used to ensure the instructions are provided unobtrusively, including use of transparency settings to make instructions legible, resizing techniques, variable shading, font size/contrast/style adjustments, and the like. | 2012-05-10 |
20120115123 | PROVIDING LEARNING TOOLS - In general, techniques are disclosed for providing an electronic learning tool configured to teach content associated with one or more subject areas. A request for a provisioning of the electronic learning tool is received from a sponsor. A request for a generation of the content is communicated to an entity having access to knowledge of the one or more subject areas. The content is received from the entity. The content is provided to a tool generation entity for generation of the electronic learning tool. The electronic learning tool is received from the tool generation entity. The electronic learning tool is provided to one or more users associated with the sponsor. | 2012-05-10 |
20120115124 | IRRADIATION OF RED BLOOD CELLS AND ANAEROBIC STORAGE - A blood storage system comprising: a collection vessel for red blood cells; an oxygen or oxygen and carbon dioxide depletion device; a storage vessel for red blood cells; tubing connecting the collection vessel to the oxygen or oxygen and carbon dioxide depletion device and the oxygen or oxygen and carbon dioxide depletion device to the storage vessel; and a gamma or X-ray irradiating device is used to irradiate red blood cells stored in the vessel, storing red blood cells under anaerobic conditions. | 2012-05-10 |
20120115125 | ASSAY FOR DETECTING AND QUANTIFYING HIV-1 - Method of detecting HIV-1 nucleic acids using nucleic acid amplification and a molecular torch hybridization probe. The invented method is characterized by high levels of precision in the quantitation of HIV-1 targets at low copy numbers, and by accurate detection of different HIV-1 subtypes, including M group and O group variants. | 2012-05-10 |
20120115126 | Compositions and Methods for Rapid, Real-Time Detection of Influenza A Virus (H1N1) Swine 2009 - Disclosed are oligonucleotide amplification primers and detection probes specific for the amplification and detection of pathogenic organisms, including for example, specific Influenza A H1N1 viral isolates. Also disclosed is a biological organism identification kit including the disclosed nucleic acid probes and primers, as well as thermal cycling reagents that is both portable and durable, and may also be self-contained for remote, or in-field analysis and identification of particular influenza isolates from a variety of biological specimen types. | 2012-05-10 |
20120115127 | MOLECULAR FLUX RATES THROUGH CRITICAL PATHWAYS MEASURED BY STABLE ISOTOPE LABELING IN VIVO, AS BIOMARKERS OF DRUG ACTION AND DISEASE ACTIVITY - The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes serve as biomarkers and are quantitated and compared with the molecular flux rates (i.e., biomarker) from control subjects (i.e., subjects not exposed to the compounds). Any change in the biomarker in the subject relative to the biomarker in the control subject provides information to evaluate therapeutic efficacy of an administered drug or a toxic effect and to develop the compound further if desired. In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through metabolic pathways of interest. | 2012-05-10 |
20120115128 | SELECTIVE PROTEIN LABELING - The present invention is related to methods of detecting protein-protein interactions in living cells, as well as detecting the formation and/or inhibition of protein-protein interactions in cells. | 2012-05-10 |
20120115129 | ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS - Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease. | 2012-05-10 |
20120115130 | METHOD FOR DETECTING TARGET CELL - A target cell detection method includes performing a test measurement on a dispersion to obtain a measurement result 1, the test measurement being an optical or electromagnetic measurement, and the dispersion including labeled particles and target cells, the labeled particles being particles on each of which a substance that specifically binds to a specific molecule present on a surface of each of the target cells is immobilized, performing measurement that is identical with the test measurement on a dispersion that includes the target cells, but does not include the labeled particles to obtain a measurement result 2, and comparing the measurement result 1 with the measurement result 2. | 2012-05-10 |
20120115131 | GENETIC LESION ASSOCIATED WITH CANCER - The invention comprises methods for identifying mutations within the 3′ UTRs of genes that lead to increased risk or probability of developing cancer. | 2012-05-10 |
20120115132 | IDENTIFICATION OF CENTROMERE SEQUENCES USING CENTROMERE ASSOCIATED PROTEINS AND USES THEREOF - The present invention is directed to methods of centromere discovery using centromere-associated proteins in a variety of experimental formats. The methods of the invention can be used on any organism, and include using Cal1, Cbf1, Cbf3, Cbf5, CenH3 (Cenp-A), Cenp-B, Cenp-C, Cenp-D, Cenp-E, Cenp-F, Cenp-G, Cenp-H, Cenp-I, Cenp-K, Cenp-L, Cenp-M, Cenp-N, Cenp-O, Cenp-P, Cenp-Q, Cenp-R, Cenp-S, Cenp-T, Cenp-U, Cenp-V, Cenp-W, Chd1, Chp1, cohesin, condensin, Dnmt3b, Fact, Gcn5p, H2A.Z, Haspin, Hjurp, HP1, Hst4, Ima1, Incep, Ino80, Kms2, Knl-2, Mif2, Mis6, Np95, Pich, Sad1, Scm3, Shugoshin, Sim3, Skp1, Sororin, Survivin, Tas3, ZW10, and homologs thereof to identify centromere sequences. The invention is also directed to artificial chromosomes comprising centromeres made according to the methods of the invention, as well as to cells comprising such artificial chromosomes. | 2012-05-10 |
20120115133 | CYANINE DYES - The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates. | 2012-05-10 |
20120115134 | METHODS FOR DIAGNOSIS AND PROGNOSIS OF CANCER - We have discovered a protein in humans, herein referred to as collagen like gene (CLG) product (SEQ ID NOS: 12 and 13), that is expressed in human prostate cancer and breast cancer cell lines but not in normal adult, placenta, lung, liver, skeletal muscle, kidney or pancreas tissues. We have also discovered that the level of CLG mRNA expression correlates positively with the metastatic potential of the cancer cell lines tested. | 2012-05-10 |
20120115135 | METHOD FOR DETECTION OF ACTIVE PERIODONTAL DISEASE AT THE LOCAL TOOTH SITE - A method for site-specific detection and early diagnosis of periodontal disease using periodontal pocket fluid biomarkers is disclosed. | 2012-05-10 |
20120115136 | PNA DIAGNOSTIC USE - The present invention pertains to certain nucleic acid analogs and related kits that are useful for the capture, recognition, detection, identification, or quantification of certain chemical or biological entities. | 2012-05-10 |
20120115137 | Methods of Predicting Osteoarthritis - The present invention relates generally to methods for predicting progression, initiation and susceptibility of osteoarthritis in human subjects using their genotype test results. | 2012-05-10 |
20120115138 | METHOD FOR IN VITRO DIAGNOSING A COMPLEX DISEASE - The present invention relates to a method and kit for in vitro diagnosing a complex disease such as cancer, in particular, acute myeloid leukemia (AML), colon cancer, kidney cancer, prostate cancer; transient ischemic attack (TIA), ischemia, in particular stroke, hypoxia, hypoxic-ischemic encephalopathy, perinatal brain damage, hypoxic-ischemic encephalopathy of neotatals asphyxia; demyelinating disease, in particular, white-matter disease, periventricular leukoencephalopathy, multiple sclerosis, Alzheimer and Parkinson's disease; in a biological sample. For the diagnosis, use is made of measuring at least two different species of biomolecules and classifying the results by means of suitable classifier algorithms and other statistical procedures. With the present invention, a significant improvement of the reliability of e.g. expression profiles alone, are achieved. In other words, in a defined collective, an up to 100% accurate positive diagnosis could be achieved, which renders the method of the present invention superior over the prior art. | 2012-05-10 |
20120115139 | METHOD FOR EVALUATING CANCER - Provided is a cancer evaluation method using a novel cancer marker for evaluating the onset, the preclinical stage, the clinical stage, or the prognosis of a cancer in a subject. At least one miRNA selected from hsa-miR-92 and hsa-miR-494 is used as the novel cancer marker in cancer evaluation. The cancer marker in a sample of a cell or a tissue is detected, and the possibility of a cancer in the sample is evaluated based on the expression level of the cancer marker. According to this evaluation method, by detecting the miRNA as the cancer marker, it becomes possible to evaluate the possibility of a cancer in the sample with excellent reliability. As a method for detecting the cancer marker, it is preferable to perform an in situ hybridization method using a labeled probe with respect to the sample that has been immobilized, for example. | 2012-05-10 |
20120115140 | Molecular Diagnosis of Fragile X Syndrome Associated with FMR1 Gene - The present invention includes a rapid, selective, and accurate method of diagnosing a human subject with a triplet repeat genetic disorder of the FMR1 gene that leads to fragile X syndrome. The present invention also includes a rapid, selective, and accurate method of diagnosing a human subject at risk for developing a triplet repeat genetic disorder of the FMR1 gene that leads to fragile X syndrome, or at risk of passing such a disorder on to their progeny. | 2012-05-10 |
20120115141 | ENDPOINT TAQMAN METHODS FOR DETERMINING ZYGOSITY OF COTTON COMPRISING Cry1F EVENT 281-24-236 - A method for zygosity analysis of the cotton Cry1F event 281-24-236 is provided. The method provides 281-24-236 event-specific and cotton endogenous reference gene-specific primers and TaqMan probe combinations for use in an endpoint biplex TaqMan PCR assay capable of determining event zygosity and for assisting in event introgression and breeding. | 2012-05-10 |
20120115142 | ENDPOINT TAQMAN METHODS FOR DETERMINING ZYGOSITY OF COTTON COMPRISING Cry1Ac EVENT 3006-210-23 - A method for zygosity analysis of the cotton Cry1Ac event 3006-210-23 is provided. The method provides 3006-210-23 event-specific and cotton-genome-specific primers and TaqMan probe combinations for use in an endpoint biplex TaqMan PCR assay capable of determining event zygosity and for assisting in event introgression and breeding. | 2012-05-10 |
20120115143 | Universal Probe Assay Methods - Reagents and methods are provided for detecting the presence of a target polynucleotide in a sample are disclosed. In one aspect, a method for producing a labeled amplification product by amplifying a target nucleic acid sequence to produce an amplification product comprising the target sequence, a first probe-binding sequence 5′ to the target sequence, and a second probe-binding sequence 3′ to the target sequence, thereby producing an amplification product; and hybridizing a first detection probe to the amplification product, said first detection probe comprising a first segment that hybridizes to the first probe-binding sequence and a second segment that hybridizes to the second probe-binding sequence, thereby producing a labeled amplification product is disclosed. | 2012-05-10 |
20120115144 | Detection of Extracellular Tumor-Associated Nucleic Acid in Blood Plasma or Serum - This invention relates to detection of specific extracellular DNA in plasma or serum fractions of human or animal blood associated with neoplastic, pre-malignant or proliferative disease. Specifically, the invention relates to detection tumor-associated DNA, and to those methods of detecting and monitoring tumor-associated DNA found in the plasma or serum fraction of blood by using DNA extraction and amplification with or without enrichment for DNA. The invention allows the selection and monitoring of patients for various cancer therapies including receptor tyrosine kinase inhibitor therapies. | 2012-05-10 |
20120115145 | STRAND DISPLACEMENT ACTIVITY OF MODIFIED POLYMERASES AND USES THEREOF - The present invention is directed to the use of the strand displacement activity of a modified polymerase. The present invention is more specifically directed to a modified Taq DNA polymerase, which exhibits strand displacement activity, whereas the native polymerase does not possess the strand displacement activity. | 2012-05-10 |
20120115146 | METHOD OF ANALYZING GENETICALLY ABNORMAL CELLS - The present invention relates to a method for analyzing genetically abnormal cells including (a) preparing a cell sample containing eukaryotic cells, (b) conducting an antigen-antibody reaction to cells contained in the cell sample using antibodies which specifically bind to a molecule existing on the cell surface of eukaryotic cells after (a), (c) subjecting the cells contained in the cell sample to a permeation treatment after (b), (d) subjecting the cells contained in the cell sample to an immobilization treatment after (b), (e) conducting FISH to the cells contained in the cell sample using nucleic acid probes after (d), (f) analyzing fluorescence signals from the nucleic acid probes in the cells contained in the cell sample using a three-dimensional image analysis method after (e), and (g) determining whether the cells contained in the cell sample are genetically abnormal cells or not based on the results of (b) and (f). | 2012-05-10 |
20120115147 | NEUROPSYCHIATRIC TEST REPORTS - Methods and reports for presenting genetic information that is patient-specific and relevant to treatment of neuropsychiatric disorders, including treatment resistant depression. The methods and reports described include genotype information for each of six specific genetic loci and allow patient-specific therapy for the effective treatment of treatment resistant disorders (TRD). | 2012-05-10 |
20120115148 | Reagents and Methods for Detecting Neisseria Gonorrhoeae - This invention provides compositions and methods for detecting | 2012-05-10 |
20120115149 | SEROTONIN TRANSPORTER GENE AND TREATMENT OF ALCOHOLISM - The gene (SLC6A4) responsible for encoding the serotonin transporter (SERT) has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on diagnosing variations in the polymorphisms of the SERT gene and expression and activity of the SERT gene, as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders, for monitoring treatment and/or abuse (addictive behavior), and for determining which treatment should be used. | 2012-05-10 |
20120115150 | miRNA BIOMARKERS FOR THE DIAGNOSIS OF DUCHENNE MUSCULAR DYSTROPHY, ITS PROGRESSION AND FOR MONITORING THERAPEUTIC INTERVENTIONS - The invention refers to diagnosis and therapy of muscle degenerative disorders, as Duchenne Muscular Dystrophy (DMD) by means of a class of specific miRNAs. | 2012-05-10 |
20120115151 | METHOD FOR TESTING A SUBJECT THOUGHT TO BE PREDISPOSED TO HAVING METASTATIC CANCER USING DELTA133P53BETA - The present invention concerns a method of testing a subject thought to be predisposed to having a metastatic cancer which comprises: analyzing a biological sample from said subject for detecting the presence of a p53 isoform selected from the group consisting of Δ133p53, Δ133p53γ and Δ133p53β, the presence of said p53 isoform being indicative of a metastatic cancer. | 2012-05-10 |
20120115152 | Screening Method - The present invention relates to clinical diagnosis of Alzheimer's disease or early-stage Alzheimer's disease in the live patient. In particular, the invention provides a screening method which can be used to assist with diagnosis of Alzheimer's disease in live human subjects, or to identify human subjects with a predisposition to Alzheimer's disease. | 2012-05-10 |
20120115153 | MARKER FOR PROGNOSIS OF LIVER CANCER - The present invention relates to a marker for the prognosis of liver cancer; a composition for estimating the prognosis of liver cancer, which contains a substance for detecting a change in the expression level of the prognostic marker for liver cancer; a kit for estimating the prognosis of liver cancer, which contains the composition for estimating liver cancer prognosis; a method for estimating the prognosis of liver cancer using the marker for liver cancer prognosis; and a method for screening a therapeutic agent for liver cancer using the marker for the prognosis of liver cancer. | 2012-05-10 |
20120115154 | REFERENCE MARKERS FOR BIOLOGICAL SAMPLES - DNA oligomers comprising sequences that are absent from the genome of one or more organisms of interest are used as reference markers (RMs). The RMs are added to biological samples to “tag” and subsequently identify the samples as authentic and to distinguish tagged samples from samples obtained without said markers, for example, in forensic, medical, legal and other applications. | 2012-05-10 |
20120115155 | Method for Amplifying Nucleic Acid - Disclosed is a nucleic acid amplification method which is based on a new principle and enables to amplify a nucleic acid having a specific nucleotide sequence in a simple manner, within a short time and with efficiency. The nucleic acid amplification method comprises the steps of: (a) obtaining a linear DNA fragment by performing a DNA polymerase elongation reaction by using a template DNA comprising a base sequence to be amplified and a primer pair comprising a primer having a base sequence complementary to a region adjacent to a 3′ end of the base sequence to be amplified and a chemically modified 3′ end; and (b) performing a strand displacement-type DNA polymerase elongation reaction on a circular single-stranded DNA comprising the base sequence to be amplified and serving as a template, with a 3′ end of the linear DNA fragment obtained in (a) serving as an origin of replication. | 2012-05-10 |
20120115156 | RECOMBINANT PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEINS 4 AND 5 AND THEIR USE - Accordingly, the invention provides constructs in which the nucleic acids encoding | 2012-05-10 |
20120115157 | Methods for Screening for Antibiotic Compounds - The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell. | 2012-05-10 |
20120115158 | METHOD TO DETERMINE EMBRYO AND OOCYTE QUALITY BASED ON CERAMIDASE - The present invention relates to a method of predicting the likelihood of embryo or oocyte survival. This method involves providing a sample of an embryo, an oocyte, or surrounding liquid or cells, and screening the sample for ceramidase expression or activity. The ceramidase expression or activity obtained through said screening is then correlated to a prediction of the likelihood of embryo or oocyte survival. Also disclosed is a kit. | 2012-05-10 |
20120115159 | BLOOD ANALYZER AND BLOOD ANALYZING METHOD - The present invention provides a blood analyzer and a blood analyzing method capable of obtaining information regarding B lymphocytes and T lymphocytes without using a fluorescence-labeled antibody. The blood analyzer of the present invention includes a blood specimen supplying portion, a sample preparation portion that prepares a measurement sample without using a fluorescence-labeled antibody by mixing a blood specimen supplied from the blood specimen supplying portion, a hemolyzing agent, and a fluorescent dye that stains nucleic acid, a light source, a first detector that detects fluorescence, a second detector that detects scattered light, and information processing portion that classifies lymphocytes based on the intensity of fluorescence and scattered light, and based on the fluorescence intensity of the classified lymphocytes, obtains information regarding B-lymphocytes and T-lymphocytes. | 2012-05-10 |
20120115160 | METHOD FOR DETECTING INVASIVE MICROVESCLES DERIVED FROM TUMOR CELLS - The present application relates to the isolation and analysis of populations of microvesicles, such as populations of microvesicles that are shed by tumor cells and contain the protein ARF6. Invasive microvesicles from tumor cells contain a variety of specific proteins, including ARF6. | 2012-05-10 |
20120115161 | COMPOSITIONS AND METHODS FOR DEMONSTRATING SECRETORY IMMUNE SYSTEM REGULATION OF STEROID HORMONE RESPONSIVE CANCER CELL GROWTH - Serum-containing and serum-free immunoglobulin inhibitors of steroid hormone responsive cancer cell growth are disclosed, along with their methods of production. Also disclosed are defined cell culture media, assay protocols, and model systems using the inhibitors for demonstrating steroid hormone growth effects of natural and synthetic substances, and other cell culture applications. The disclosed compositions and methods employing the immunoglobulin inhibitors are also useful as reagents in research, and for the diagnosis, treatment and prevention of mucus epithelial cancers. | 2012-05-10 |
20120115162 | ANTI-FATTY ACID AMIDE HYDROLASE-2 ANTIBODIES AND USES THEREOF - Antibodies that specifically bind to fatty acid amide hydrolases and methods of using the antibodies are provided herein. | 2012-05-10 |
20120115163 | MARKED PEPTIDES AND USE THEREOF FOR ASSAYING CIRCULATING IRAP - A method for the assay of the circulating extracellular portion of the IRAP protein (“insulin responsive aminopeptidase”) includes at least one stage of quantitative assay of the purified, secreted, extracellular portion of IRAP, via at least one labelled peptide, the labelled peptide interacting specifically with the extracellular portion of IRAP. | 2012-05-10 |
20120115164 | MAMMALIAN CYTOKINES; RELATED REAGENTS - Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided. | 2012-05-10 |
20120115165 | BIOMARKERS FOR DETECTION AND DIAGNOSIS OF HEAD AND NECK SQUAMOUS CELL CARCINOMA - Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid, hyaluronidase and CD44 to diagnose HNSCC are described. | 2012-05-10 |
20120115166 | DIAGNOSTIC METHODS FOR THE DETECTION OF RISK OF NEURODEVELOPMENTAL DISORDERS - The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of neural tissue, including autism spectrum disorder (ASD). The invention further provides methods of diagnosing whether an individual has a neurodevelopmental disorder, including an ASD, and methods for determining the risk that a mother's future offspring will develop an a neurodevelopmental disorder, including an ASD. | 2012-05-10 |
20120115167 | METHOD AND APPARATUS FOR ISOLATING A TARGET BIOENTITY FROM A BIOLOGICAL SAMPLE - A method for isolating a target bioentity from a biological sample, comprises contacting the biological sample with a magnetically-labelled ligand having selective binding affinity for the target bioentity, or for a determinant on the target bioentity, to form a target bioentity/labelled ligand complex, locating a separation module having a defined fluid flow path in the magnetic field of a magnetic module, the magnetic module comprising an array of at least two magnets in which adjacent magnets in the array are aligned with opposing polarity; passing the biological sample through the separation module to subject the biological sample to the magnetic field while the sample is passing through the defined fluid flow path to magnetically capture the target bioentity/labelled ligand complex by arresting or hindering movement of the complex within the defined fluid flow path; removing the separation module from the magnetic field; and recovering the target bioentity/labelled ligand complex from the fluid flow path. | 2012-05-10 |
20120115168 | BIOASSAY AND PEPTIDES FOR USE THEREIN - The invention provides a bioassay for detection of | 2012-05-10 |
20120115169 | HYDROXYCHOLESTEROL IMMUNOASSAY - Provided is a derivative of 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a protein conjugated to the above derivative. Further provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Additionally, a method of making antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Also, a method of assaying for 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Additionally provided is a kit for detecting 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. A method of detecting an enzyme or enzymes utilized in phase II drug metabolism is also provided. Also, a method of detecting an enzyme that synthesizes 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Further provided is a method of evaluating progression of multiple sclerosis in a patient. Also provided is a method of determining whether a treatment for multiple sclerosis in a patient is effective. Further, a method of evaluating progression of Huntington's disease in a patient is provided. Additionally provided is a method of determining whether a treatment for Huntington's disease in a patient is effective. | 2012-05-10 |
20120115170 | SERUM MG53 AS A DIAGNOSTIC MARKER FOR TISSUE INJURY - Disclosed herein are compositions and methods for measuring the level of MG53 found in a biological fluid as a biomarker for a disease or disorder, e.g., tissue damage, exercise capacity or a muscle-related disease or disorder. In addition, the invention relates to targeting the native MG53 found in the blood as a therapeutic approach. | 2012-05-10 |
20120115171 | Method For Diagnosing Thrombophilia - The invention relates to a method for diagnosing thrombophilia in a subject suffering from HIV or from a systemic auto-immune disease, said method comprising determining in a blood sample obtained from said subject the level of free Protein S having Activated Protein C (APC) cofactor activity and the level of total Protein S. | 2012-05-10 |
20120115172 | PTEN/AKT METHODS AND COMPOSITIONS RELATING TO BMP - The present invention relates to a purified molecules, including antibodies, that bind specifically to murine β-catenin phosphorylated at amino acid position Serine | 2012-05-10 |
20120115173 | BIOMARKERS FOR MOTOR NEURON DISEASE - The invention provides methods of determining a diagnosis or prognosis of motor neuron disease in a mammal comprising determining the expression level of one or more proteins or polypeptides of the renin-angiotensin system in a sample taken from a subject. Similarly, aberrant post-translational modification of the proteins or polypeptides as compared to a negative control indicates a diagnosis of disease. | 2012-05-10 |
20120115175 | METHODS FOR DIAGNOSING ELEVATED RIGHT OR LEFT VENTRICULAR FILLING PRESSURE - The present invention features a method of diagnosing elevated left or right ventricular filling pressure and cardiovascular dysfunction in a subject by detecting increased levels of sEng in a biological sample from the subject. | 2012-05-10 |
20120115176 | METHOD FOR DETECTING COMPOUNDS MODULATING DIMERS OF VFT DOMAIN MEMBRANE PROTEINS - The invention relates to a method for selecting compounds having a modulating effect on the activation state of a dimer of VFT-domain proteins expressed in cell membranes present in a measuring medium, said dimer consisting of a first protein and of a second protein, said proteins being identical or different, wherein this method comprises the following steps:
| 2012-05-10 |
20120115177 | Compositions and Methods for Diagnosis of Shock - Methods and kits for diagnosis and staging of shock, and especially non-septic shock are presented in which protease activities and/or volatile compounds are measured from a biological sample to so identify and/or stage shock. | 2012-05-10 |
20120115178 | Method of Diagnosing Gastric Cancer by Using Human Neutrophil Peptide 1-3 - Human neutrophil peptide (HNP) 1-3, used as diagnostic and therapeutic molecular probes, are found in clinical tissues of gastric cancer patients. In the analytical process according to the present disclosure, pairs of gastric cancer tissues are used to seek the putative biomarkers by proteomic strategy based on matrix assisted laser desorption ionization-imaging mass spectrometry (MALDI-IMS). Then, three differential biomarkers, including HNP-1, -2 and -3, are identified (P<0.001) and overexpressed in gastric cancer. At last, western blotting and immunohistochemistry are used to validate the protein expression in gastric cancer tissues. In conclusion, the use of the up-regulated proteins, HNP1-3, helps diagnosis and therapy in clinical for gastric cancer after validating the sensitivity and specificity. | 2012-05-10 |
20120115179 | ARRANGEMENT, SUBSTRATE AND METHOD FOR PREPARING A CELL SAMPLE - A flexible, thin, elongated band is used as a substrate. Similarly to a magnetic tape, the band is unwound from a feed reel and is transported past an outlet opening of a receptacle containing the cells such that the cells are poured onto the band. Subsequently, the band containing the cells applied thereon is wound onto a take-up reel. The take-up reel is fixed on a drive shaft which can be rotated by a drive mechanism. The rotation thus achieved has the effect that the band is unwound, transported past the outlet opening and finally wound up. In addition, spacers are provided at the upper surface of the band in order to prevent the contacting of radially adjacent sections of the band containing the cells in a wound-up state. | 2012-05-10 |
20120115180 | USE OF ANIMAL CELLS FOR SCREENING PROBIOTIC BACTERIA STRAINS - The present invention relates to an in vitro and/or ex vivo method of screening probiotic bacterial strains. The present invention also relates to a method of assessing quality of probiotic culture. In addition, the present invention relates to use of animal cells in screening of a probiotic strain. The present invention also relates to use of animal cells in assessing quality of probiotic culture. | 2012-05-10 |
20120115181 | SYSTEMS AND METHODS FOR CEREBROSPINAL FLUID COLLECTION - A test tube insert includes a flange having a width greater than a width of a mouth of a larger test tube into which the insert is to be inserted. The flange defines a first central opening. An annulus extends integrally downward from the flange. The annulus includes a fenestrated wall and a floor defining a second central opening. A small test tube body, smaller than the larger test tube, extends integrally downward from the floor of the annulus with the second central opening forming a mouth of the small test tube body. The test tube insert is disposed in the mouth of the larger test tube. Fluid is transferred through the central opening and the fluid fills the small test tube body of the test tube insert and flows through the fenestrated wall once the small test tube body is full into the larger test tube. | 2012-05-10 |
20120115182 | MASS SPECTROMETRIC DIAGNOSIS OF SEPTICEMIA - The invention mainly relates to the mass spectrometric identification of pathogens in blood cultures from blood-stream infections (septicemia). The invention provides a method with which microbial pathogens can be separated in purified form from blood after a relatively brief cultivation in a blood culture flask, without any interfering human proteins or any residual fractions of blood particles such as erythrocytes and leukocytes, and can be directly identified by mass spectrometric measurement of their protein profiles. The method is based on the use of relatively strong tensides to destroy the blood particles by dissolving the weak cell membranes and most of the internal structures of the blood particles; in spite of the fact that tensides are regarded as strong ionization inhibitors in MALDI and other ionization processes required for mass spectrometric measurements. This method allows unknown pathogens to be obtained in their pure form by centrifuging or filtration and to be identified on the taxonomic level of species or subspecies. Problems with DNA from high levels of leukocytes can be resolved by special measures. After sufficient cultivation, the identification in a mass spectrometric laboratory takes only half an hour. | 2012-05-10 |
20120115183 | Detector Arrangement for Blood Culture Bottles with Colorimetric Sensors - A detector arrangement is disclosed for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO | 2012-05-10 |
20120115184 | METHOD FOR THE DETECTION OF MASTITIS AND MILK QUALITY AND MASTITIS SENSOR - A mastitis sensor and a method for detection of mastitis and determination of milk quality in real time (on-line). Methods and apparatuses for the rapid non-invasive determination of the concentration of dissolved molecular oxygen in milked milk are disclosed. Mastitis sensors are disclosed that include a fiberoptic, amperometric or potentiometric device for the determination of oxygen concentration, a device for data acquisition and processing, mastitis indicator and a device that generates a signal for the automatic on-line elimination of substandard milk of infected animals to prevent the pollution of bigger quantities of milk. | 2012-05-10 |
20120115185 | DEVICE AND METHOD FOR RECOVERING BIOGAS - A device for recovering biogas, comprising at least one fermenter ( | 2012-05-10 |
20120115186 | FERMENTATIVE PRODUCTION OF ETHANOL FROM GLUCOSE, GALACTOSE AND ARABINOSE EMPLOYING A RECOMBINANT YEAST STRAIN - The present invention relates to a process for the production of one or more fermentation product from a sugar composition, comprising the following steps:
| 2012-05-10 |
20120115187 | Production Of Recombinant Proteins Utilizing Non-Antibiotic Selection Methods And The Incorporation Of Non-Natural Amino Acids Therein - Provided herein are methods and compositions for expression of a nucleic acid construct comprising nucleic acids encoding a) a recombinant polypeptide, and b) a prototrophy-restoring enzyme in a host cell that is auxotrophic for at least one metabolite. In various embodiments, the host cell is auxotrophic for a nitrogenous base compound or an amino acid. The invention involves introducing an analogue into the growth media for the host cell such that the analogue is incorporated into the recombinant polypeptide or a nucleic acid coding sequence thereof. In various embodiments, the compositions and methods disclosed herein result in improved recombinant protein expression compared to expression of recombinant protein in an antibiotic selection system, or compared to expression of the recombinant protein in an expression system that lacks a metabolite analogue. | 2012-05-10 |
20120115188 | CHIMERIC DNA POLYMERASES - The present invention provides, among other things, chimeric DNA polymerases containing heterologous domains having sequences derived from at least two DNA polymerases that have at least one distinct functional characteristics (e.g., elongation rate, processivity, error rate or fidelity, salt tolerance or resistance) and methods of making and using the same. In some embodiments, the present invention can combine desired functional characteristics (e.g., high processivity; high elongation rate; thermostability; resistance to salt, PCR additives (e.g., PCR enhancers) and other impurities; and high fidelity) of different DNA polymerases in a chimeric polymerase. | 2012-05-10 |
20120115189 | MICROFLUIDIC AND NANOFLUIDIC DEVICES, SYSTEMS, AND APPLICATIONS - The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps. | 2012-05-10 |
20120115190 | AIR COOLING SYSTEMS AND METHODS FOR MICROFLUIDIC DEVICES - Systems and methods for air cooling a microfluidic device using confinement channels to isolate cooling air from exposed liquids are disclosed. The systems and methods may also thermally condition the cooling airflow for improved robustness of the microfluidic device. In one embodiment, the air cooling system includes a split-level cooling manifold including an inlet duct that directs cooling air to a microfluidic device and an outlet duct that directs air heated by the microfluidic device away from the microfluidic device. The temperature of cooling air may be measured. The cooling air may be preheated to a temperature that is higher than an expected ambient temperature. The temperature of the cooling air after being heated by a microfluidic device may be measured. | 2012-05-10 |
20120115191 | PRODUCTION OF FRUCTO-OLIGOSACCHARIDE AND DERIVATIVES BY USE OF ASPERGILLUS SPP - There is provided a new strain, that is | 2012-05-10 |
20120115192 | METHOD FOR PRODUCTION OF FERMENTABLE SUGARS FROM BIOMASS - A process for production of fermentable sugars from biomass using multi-enzyme multi-step system is provided herein. The process disclosed in the present invention provides high yielded sugars in less time period. The multi-enzyme system disclosed in the present invention converts celluloses, hemicelluloses and/or mixture thereof to fermentable sugar with higher efficiency and better economics than the process known in the prior art. Cellulose and hemicelluloses fractions derived from natural sources such as any lignocellulosic biomass are saccharified in a shortened time with higher conversion rates of intermediates with modified enzymatic compositions/groups of the Multi-enzyme system to enhance the rate thus providing an economical cellulose and hemicellulose saccharification process. | 2012-05-10 |
20120115193 | TRANSFORMATION OF GLYCEROL AND CELLULOSIC MATERIALS INTO HIGH ENERGY FUELS - The present invention includes a system and method for making a biofuel comprising: providing a nitrogen-limiting, minimal growth media comprising glycerol, sugars generated from cellulosic biomass or both, under conditions in which an oleaginous microbe converts the growth media into at least one of triacylglycerol, neutral lipids, fatty acids, long-chain fatty acids, and hydrocarbons that is secreted by the microbe. | 2012-05-10 |
20120115194 | MICROORGANISMS FOR THE PRODUCTION OF ADIPIC ACID AND OTHER COMPOUNDS - The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam. | 2012-05-10 |
20120115195 | PRODUCT OF FATTY ACID ESTERS FROM BIOMASS POLYMERS - The invention provides consolidated bioprocessing methods and host cells. The host cells are capable of directly converting biomass polymers or sunlight into biodiesel equivalents and other fatty acid derivatives. In particular, the invention provides a method for producing biodiesel equivalents and other fatty acid derivatives from a biomass polymer including providing a genetically engineered host cell, culturing the host cell in a medium containing a carbon source such that recombinant nucleic acids in the cell are expressed, and extracting biodiesel equivalents and other fatty acid derivatives from the culture. | 2012-05-10 |
20120115196 | CORYNEFORM BACTERIUM TRANSFORMANT AND PROCESS FOR PRODUCING ISOBUTANOL USING THE SAME | 2012-05-10 |
20120115197 | Ketol-Acid Reductoisomerase Using NADH - Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from | 2012-05-10 |
20120115198 | METHODS FOR INCREASING THE PRODUCTION OF ETHANOL FROM MICROBIAL FERMENTATION - A stable continuous method for producing ethanol from anaerobic fermentation of a gaseous substrate containing at least one reducing gas in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor. The free acetic acid concentration in the bioreactor is maintained at less than 5 g/L free acid. This method allows ethanol to be produced in the fermentation broth in the bioreactor at a productivity of greater than 10 g/L per day. Both ethanol and acetate are produced in a ratio of ethanol to acetate ranging from 1:1 to 20:1. | 2012-05-10 |
20120115199 | Enzymatic Hydrolysis Of Pretreated Lignocellulose-Containing Material With Basidiomycota Mycelia And Yeast Cells - A method for producing a fermentation product from a lignocellulose-containing material comprises pre-treating the lignocellulose-containing material; introducing treated basidiomycota mycelia and/or yeast cells to the pre-treated lignocellulose-containing material; exposing the pre-treated lignocellulose-containing material to an effective amount of hydrolyzing enzyme; and fermenting with a fermenting organism to produce a fermentation product. | 2012-05-10 |
20120115200 | CONTINUOUS PROCESS FOR THE PRODUCTION OF ETHANOL FROM LIGNOCELLULOSIC BIOMASS - A continuous process for the recovery of ethanol from hemicellulose and cellulose from lignocellulosic biomass. Yield of fermentable sugars can be maximized by continuous operation of the pre-treatment system and careful selection of pretreatment conditions including the addition of only small amounts of dilute mineral acid and low pressure. With this approach, the xylose component that is mainly present in its unfermentable oligomeric form in known pre-hydrolysis Kraft processes can be recovered more efficiently and as a monomer that can be fermented by xylose fermenting yeasts and bacteria. Due to the use of only dilute acids, there is a very low loss of glucose and xylose hence very low production of toxic chemicals (e.g. HMF, furfural) in the pretreatment step. The resulting overall fermentation efficiency of both hexose and pentose sugars is 90% of the theoretical maximum. | 2012-05-10 |
20120115201 | Methods and Systems for Producing Biomass and/or Biotic Methane Using an Industrial Waste Stream - Systems and methods for capture and sequestration of CO | 2012-05-10 |
20120115202 | PHOTOCATALYTIC HYDROGEN PRODUCTION IN CYANOBACTERIA - A cyanobacterial cell comprising a PSI complex which accepts electrons from at least one respiratory cytochrome is disclosed. Methods of generating same and use of same for the production of hydrogen gas are also disclosed. | 2012-05-10 |
20120115203 | METHOD FOR PRODUCING 4-HYDROXY-L-ISOLEUCINE - A highly active L-isoleucine dioxygenase from | 2012-05-10 |
20120115204 | VIRUS FILTRATION OF LIQUID FACTOR VII COMPOSITIONS - The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide). | 2012-05-10 |
20120115205 | Botulinum Neurotoxin Serotype B Activatable Botulinum Neurotoxin Serotype Bs - The specification discloses modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located in the di-chain loop region; and method of producing modified Clostridial toxins comprising Clostridial toxin substrate cleavage site located within the di-chain loop region. | 2012-05-10 |
20120115206 | NON-TUMORIGENIC MDCK CELL LINE FOR PROPAGATING VIRUSES - The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g., influenza virus) in the novel cell lines of the invention. | 2012-05-10 |
20120115207 | ENHANCED PRODUCTION OF PAPILLOMAVIRUS-LIKE PARTICLES WITH A MODIFIED BACULOVIRUS EXPRESSION SYSTEM - The present invention is concerned with the provision of a method for manufacturing papillomavirus like particles (PV-VLP), comprising the steps of a) culturing a host cell lacking protease activity and comprising an expression vector, wherein said expression vector comprises at least one polynucleotide encoding a PV L1 polypeptide, and b) obtaining VLPs from the host cell. Also proposed is a host cell lacking protease activity and comprising an expression vector, wherein said expression vector comprises a polynucleotide encoding at least one PV L1 polypeptide. Furthermore, a method for the manufacture of a pharmaceutical composition for the treatment or prevention of PV-related disease comprising the steps of manufacturing PV-VLPs and the further step of formulating the VLPs as a pharmaceutical composition is proposed as well as an expression vector comprising at least one polynucleotide encoding a PV L1 polypeptide but lacking a functional gene for a v-cath protease. | 2012-05-10 |
20120115208 | MODULAR METHOD FOR RAPID ASSEMBLY OF DNA - The invention is directed to methods, kits and compositions using specially designed nucleic acid components for efficient assembly of a DNA construct. The method involves a) incubating a support with a first form of nucleic acid components under conditions to form support-bound nucleic acid component complexes; b) removing unbound first form nucleic acid components; c) incubating the support-bound first form nucleic acid component complexes with a second form of nucleic acid components under conditions to anneal and link the second form to the first form; d) removing unbound second form nucleic acid components; e) repeating steps c) and d) until the DNA construct is generated; and f) eluting the DNA construct from the support. The first and second forms of the nucleic acid component comprise sticky ends such that each form cannot link to itself but can link to each other to form an alternating head to tail sequence. | 2012-05-10 |
20120115209 | Method For Culturing Microorganisms, Bioreactor For Implementing Same And Method For Producing Such A Bioreactor - The present invention thus aims to propose a bioreactor which has an improved yield (concentration, productivity), which is capable of culturing microorganisms sensitive to mechanical stresses, and which is energy-saving. The subject matter of the invention is a method for culturing microorganisms in suspension in a culture medium, in which the microorganism suspension is made to flow in a channel which has means for generating mixing by Lagrangian chaos when the microorganism suspension circulates in said channel. | 2012-05-10 |
20120115210 | OUTDOOR CULTIVATOR FOR PHOTOSYNTHETIC MICROORGANISMS - A novel waterborne cultivator, which provides the benefits of known systems for culture of photosynthetic micro-organisms in a novel configuration, incorporating a simplified, two-phase rotary mixing and gas injection system, the two phases being liquid and gas (CO | 2012-05-10 |
20120115211 | Apparatus for Testing the Quality of a Fluid Sample - Apparatus for testing the quality of a fluid sample comprising a body defining an interior space including a primary chamber and one or more secondary chambers, the apparatus having a first configuration in which it is arranged to hold at least some of the fluid sample in the primary chamber and a second configuration in which it is arranged to isolate a first portion of the fluid sample within the one or more secondary chambers whilst retaining a second portion of the fluid sample in the primary chamber. | 2012-05-10 |
20120115212 | Assay Tube - A non-instrumented biochemical assay device, such as a device for the processing of clinical specimens for molecular diagnostic applications. In one embodiment, an assay device comprises a lid which covers a reagent tube, which is disposed on a base. The platform utilizes chemical heating and optional temperature modulation by phase change material to prepare the sample and to amplify the target nucleic acid using Loop-Mediated Isothermal Amplification. The device features a simple indicator for a positive reaction, for example turbidity or fluorescence. | 2012-05-10 |
20120115213 | SYSTEMS FOR BIOAGENT IDENTIFICATION - The present invention provides systems and methods for analysis of samples, particularly biological and environmental sample to detect biomolecules of interest contained therein. A variety of system components are described herein, including, but not limited to, components for sample handling, mixing of materials, sample processing, transfer of materials, and analysis of materials. The invention further provides mechanisms for combining and integrating the different components and for housing, moving, and storing system components or the system as a whole. The systems may include any one or more or all of these components. The system finds particular use when employed for analysis of nucleic acid molecule using mass spectrometry, however, the invention is not limited such specific uses. | 2012-05-10 |
20120115214 | PORTABLE HIGH GAIN FLUORESCENCE DETECTION SYSTEM - An instrument for fluorometric assays in liquid samples is disclosed. The instrument may include multiple optical channels for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. The disclosed instrument finds utility in any number of applications, including microfluidic molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general. | 2012-05-10 |
20120115215 | LIGHT SOURCE REFLECTOR - A light source reflector includes a structure having three or more internal reflective surfaces defining a first light entry aperture and a second light exit aperture having an area that is greater than the area of the entry aperture. A single light source, or a plurality of uniformly distributed light sources, such as one or more LEDs, located proximal the entry aperture provides illumination, which impinges on the reflective surfaces from the entry aperture and is reflected off the surfaces to provides a substantially uniform illumination pattern exiting the exit aperture. The reflector advantageously allows for the use of a source (e.g., LED(s)) that is smaller than the targeted area of illumination and also avoids creating hot-spots as the reflector does not focus the light, but rather reflects mirror images of the source off of the reflective surfaces. | 2012-05-10 |
20120115216 | CONTAINER FOR TESTING FOR MICRO-ORGANISMS - A multi-compartment resealable container for testing for the presence of micro-organisms is provided with or adapted to receive a sample in a first substantially rigid transparent compartment, a growth medium in a second compartment, and a sanitizer in a third compartment, the compartments being separated by foil seals, the second and third compartments have an associated plunger which when depressed causes serrated cutters to puncture the foil seal and allow the contents to be added to the liquid containing or comprising the sample. | 2012-05-10 |
20120115217 | DEVICE AND METHOD FOR PHOTOSYNTHETIC CULTURE - A device and system for growing a photosynthetic culture is provided which employs one or a plurality of vertically disposed photopanels having interior cavities configured for holding liquid and the photosynthetic culture such as algae. The inner chamber of the photopanels may have a shape that is structurally supported by bridging elements. The bridging elements may be formed as stepped cones that may function as light guides to the interior chamber. | 2012-05-10 |
20120115218 | BIOREACTOR COMPRISING A MIXING CHAMBER - The invention relates to a bioreactor ( | 2012-05-10 |
20120115219 | High affinity binding site of HGFR and methods for identification of antagonists thereof - Use of a polynucleotide encoding or a polypeptide comprising at least the extra-cellular IPT-3 and IPT-4 domains of hepatocyte growth factor receptor for the screening and/or development of pharmacologically active agents useful in the treatment of cancer, preferably a cancer with dysregulation of hepatocyte growth factor receptor. | 2012-05-10 |