19th week of 2013 patent applcation highlights part 45 |
Patent application number | Title | Published |
20130116094 | Exercise apparatus adjustable for sidewise moving - An exercise apparatus includes a base having a carrier, two brackets attached to the carrier and adjustable relative to carrier between a forwardly directed position and a sidewise directed position, and two foot supports pivotally attached to the brackets and to be pivoted and swung forwardly and rearwardly relative to the brackets and the carrier when the brackets are attached to the carrier at the forwardly directed position, and the foot supports are allowed to be pivoted and swung sidewise relative to the brackets and the carrier when the brackets are attached to the carrier at the sidewise directed position. | 2013-05-09 |
20130116095 | Treadmill with workstation - A treadmill includes a tread assembly, a supporting frame, a control unit and a tread utility assembly. The supporting frame has a lower end portion connected to a front end portion of the tread assembly, and an upper end portion extended from the lower end portion at a predetermined evaluation. The control unit is mounted at the upper end portion of the supporting frame for controlling an operation of the tread assembly. The tread utility assembly includes a utility member frontwardly and movably extended from the control unit to form a utility platform which has a predetermined angle of inclination with respect to the control unit, wherein a user is allowed to simultaneously operate the control unit and run on the tread assembly, and accomplish a predetermined task on the utility platform in a convenient and safe manner. | 2013-05-09 |
20130116096 | WEIGHT-LIFTING BARS, METHODS OF MANUFACTURING THE WEIGHT-LIFTING BARS, AND A METHOD OF WEIGHT-LIFTING - A weight-lifting bar is provided. The weight-lifting bar includes a tubular member having a first end portion and a second end portion. The tubular member further includes an internal region. The weight-lifting bar further includes a plurality of balls disposed in the internal region of the tubular member that at least partially fills the internal region. The weight-lifting bar further includes a first endcap member configured to be coupled to the first end portion, and a second endcap member configured to be coupled to the second end portion. | 2013-05-09 |
20130116097 | Counterbalance Device for Weight Training - A counterbalance device for weight training includes a brake unit and a control unit. The brake unit includes an outer cylinder, a resistant spring received in the outer cylinder, and a screw rod extending through the outer cylinder and the resistant spring. The screw rod is connected with a steel cable of a weight training apparatus. An adjusting member is coupled around the screw rod and movably threaded into the resistant spring. A gear is provided at a front end of the resistant spring. The control unit includes a transmission gear which can be driven by a motor and is engaged with the gear. When the motor is actuated, a position of the adjusting member relative to the resistant spring can be changed, so that a number of spring coils of the resistant spring for compressing are changed, therefore a counterbalance of the weight training apparatus can be adjusted. | 2013-05-09 |
20130116098 | CLAMP DEVICE FOR ELASTIC BAND - A clamp device is for use with an elastic band and includes first and second clamp components and a coupling unit. The first clamp component has a resiliently deformable clamping arm portion connected to one end of a connecting arm portion, cooperating therewith to define a clearance, and defining a clamping side. The second clamp component has a clamping side disposed to confront that of the first clamp component. The coupling unit couples the two clamp components together in a manner that permits relative movement of the clamp components between a non-clamping state and a clamping state. In the clamping state, the clamping arm portion of the first clamp component deforms to contract the clearance and the clamping sides of the clamp components clamp cooperatively and tightly a portion of the elastic band therebetween. | 2013-05-09 |
20130116099 | Back strengthening device - A portable back strengthening device | 2013-05-09 |
20130116100 | Balancing exerciser - A balancing exerciser includes an immovable base having a socket opening for pivotally engaging with a universal joint device which has a shank, a plate is located above the base for supporting a user and includes a hole for engaging with the shank, and a knob engaged with the shank of the universal joint device and engaged with the plate for securing the plate to the shank of the universal joint device and for attempting to maintain the plate in a horizontal position or status and for allowing the user to conduct the balancing exercises or operations. The shank of the universal joint device is selected from a threaded shank for engaging with the threaded hole of the plate and for adjusting the plate toward and away from the base. | 2013-05-09 |
20130116101 | SHEET POST-PROCESSING APPARATUS AND IMAGE FORMING APPARATUS - A sheet post-processing apparatus includes a discharge portion configured to discharge a sheet having a folding portion, a conveyance portion configured to abut on a lower surface of the sheet discharged by the discharge portion, to convey the sheet downstream in a sheet conveyance direction of the discharge portion, a pressing portion arranged at a position opposing the conveyance portion, configured to press an upper surface of the sheet discharged by the discharge portion, and a moving portion configured to move the pressing portion in the sheet conveyance direction of the conveyance portion, in which the moving portion moves the pressing portion upstream in the sheet conveyance direction of the conveyance portion, to move the pressing portion from a position where the sheet discharged by the discharge portion is not pressed to a position where the sheet discharged by the discharge portion is pressed. | 2013-05-09 |
20130116102 | SYSTEM AND METHOD FOR AUTOMATED SAMPLE PREPARATION - A system for automatically processing a biological specimen is provided that includes an elevator comprising a plurality of shelves configured to receive a plurality of sample trays. The trays may comprise a plurality of sample containers containing a sample and having a plurality of respective caps engaged therewith. The trays may further include a plurality of centrifuge tube racks each containing a plurality of centrifuge tubes. The system may include a first transport mechanism, a second transport mechanism and a third transport mechanism. The system may include a chain-of-custody device configured to read identifiers on each of the containers. The system may also include a pipetting device configured to remove a portion from the sample containers and dispense the sample into the centrifuge tubes. | 2013-05-09 |
20130116103 | SYSTEMS AND METHODS FOR SEPARATING TARGET MATERIALS IN A SUSPENSION - Systems and methods that can be used to detect target materials in a suspension are disclosed. A suspension suspected of containing a target material is added to a tube, and a programmable float is added to the same tube. In one aspect, the mass of the float may be programmed by selectively adding one or more objects to the float interior so that when the tube, float and suspension are centrifuged together to separate the various materials of the suspension into layers along the axial length of the tube, the float is positioned at approximately the same level as a layer that contains the target material. The float expands the axial length of the layer between the float outer surface and the inner surface of the tube. | 2013-05-09 |
20130116104 | Centrifuge Bucket - A centrifuge bucket for centrifuging materials, in particular in laboratory centrifuges. The centrifuge bucket is operable in a very simple manner and facilitates safe and constant closure over the service life of the centrifuge bucket. Thus, the centrifuge bucket handles much better than known centrifuge buckets because real one hand operation without using a second hand is facilitated. Furthermore, the centrifuge bucket can be produced in a simpler and more cost-effective manner while being equally suitable for a given centrifugation power and centrifugation capacity. | 2013-05-09 |
20130116105 | DIRECT SMELTING PROCESS - A molten bath-based direct smelting process comprises controlling the process conditions in a direct smelting yessel so that molten slag in a molten bath of metal and slag in the vessel has a viscosity in a range of 0.5-5 poise when the slag temperature is in a range of 1400-1550° C. in the molten bath in the vessel. | 2013-05-09 |
20130116106 | METHOD FOR PRODUCING COLORED GLASS - The invention relates to a method for producing colored glass | 2013-05-09 |
20130116107 | Foam Glass Having A Low Coefficient of Thermal Expansion and Related Methods - Foam glass may include natural glass, wherein the foam glass includes greater than 5% alumina by weight of the foam glass and has a coefficient of thermal expansion ranging between 4×10 | 2013-05-09 |
20130116108 | SILICA GLASS HAVING IMPROVED PROPERTIES - The invention relates to a silica glass compound having improved physical and chemical properties. In one embodiment, the present invention relates to a silica glass having a desirable brittleness in combination with a desirable density while still yielding a glass composition having a desired hardness and desired strength relative to other glasses. In another embodiment, the present invention relates to a silica glass composition that contains at least about 85 mole percent silicon dioxide and up to about 15 mole percent of one or more dopants selected from F, B, N, Al, Ge, one or more alkali metals (e.g., Li, Na, K, etc.), one or more alkaline earth metals (e.g., Mg, Ca, Sr, Ba, etc.), one or more transition metals (e.g., Ti, Zn, Y, Zr, Hf, etc.), one or more lanthanides (e.g., Ce, etc.), or combinations of any two or more thereof. | 2013-05-09 |
20130116109 | PROCESS FOR PRODUCING A CERAMIC MATRIX COMPOSITE PART - The invention relates to a process for producing a ceramic matrix composite (CMC) part by infiltration of a suspension (S) of a ceramic powder into a fibrous reinforcement ( | 2013-05-09 |
20130116110 | Control of Clay Crystallite Size for Shrinkage Management - A method of making ceramic articles includes compounding ceramic precursor batch components that include hydrous clay. The hydrous clay includes particle components having a platy geometry. The crystallite size of the platy hydrous clay particle components is greater than a predetermined amount. Controlling such crystallite size can result in reduced shrinkage of green ware during the clay dehydroxylation stage of firing. | 2013-05-09 |
20130116111 | Molecularly Imprinted Carbon - Preparation of a molecularly imprinted carbon is described. The molecularly imprinted carbon has a surface that is imprinted on the molecular level for a specific template molecule of interest, making it highly selective for analytes corresponding to at least a portion of the template molecule. Devices including the molecularly imprinted carbon and their use in methods of detecting analytes are also described. As an example, dibutyl butylphosphonate (DBBP), a surrogate for chemical warfare agents, was used as a template molecule. Electrospun molecularly imprinted SU-8 and pyrolyzed polymer (PP) solid-phase microextraction (SPME) devices were prepared; their ability to preferentially extract DBBP from an aqueous matrix, with and without interferences present, was evaluated via comparison with non-imprinted SU-8 and PP SPME fibers. The electrospun devices demonstrated a higher selectivity for DBBP, as evidenced by their extraction time profiles. The MI-SPME fibers tested extracted at least 60% more DBBP than their non-imprinted counterparts. | 2013-05-09 |
20130116112 | COMPOSITE MEDIA FOR FLUID STREAM PROCESSING, A METHOD OF FORMING THE COMPOSITE MEDIA, AND A RELATED METHOD OF PROCESSING A FLUID STREAM - A composite media including at least one crystalline aluminosilicate material in polyacrylonitrile. A method of forming a composite media is also disclosed. The method comprises dissolving polyacrylonitrile in an organic solvent to form a matrix solution. At least one crystalline aluminosilicate material is combined with the matrix solution to form a composite media solution. The organic solvent present in the composite media solution is diluted. The composite media solution is solidified. In addition, a method of processing a fluid stream is disclosed. The method comprises providing a beads of a composite media comprising at least one crystalline aluminosilicate material dispersed in a polyacrylonitrile matrix. The beads of the composite media are contacted with a fluid stream comprising at least one constituent. The at least one constituent is substantially removed from the fluid stream. | 2013-05-09 |
20130116113 | CATALYST COMPOSITION, PRODUCTION PROCESS FOR NORBORNENE BASE COPOLYMER BY USING CATALYST COMPOSITION, NORBORNENE BASE COPOLYMER AND HEAT RESISTANT FILM PREPARED BY USING THE SAME - Provided are a catalyst composition comprising a main catalyst (A) and a promoter (B), wherein the main catalyst (A) is a complex represented by Formula (1): | 2013-05-09 |
20130116114 | Systems, Devices, and/or Methods for Preparation of Graphene and Graphene Hybrid Composite Via the Pyrolysis of Milled Solid Carbon Sources - Certain exemplary embodiments can provide a system comprising a hybrid composite. The hybrid composite can comprise tubular carbon and graphene produced via pyrolysis of a milled solid carbon source under an unoxidizing environment. When analyzed via X-ray diffraction, the hybrid composite can generate peaks at two theta values of approximately 26.5 degrees, approximately 42.5 degrees, and/or approximately 54.5 degrees. | 2013-05-09 |
20130116115 | EXHAUST GAS PURIFYING CATALYST AND PRODUCTION METHOD FOR SAME - Disclosed is a carrier for an exhaust gas purifying catalyst, the carrier containing aluminum borate represented by 9Al | 2013-05-09 |
20130116116 | PROCESS FOR PRODUCING A REFORMING CATALYST AND THE REFORMING OF METHANE - The present invention relates to a process for producing a catalyst for the reforming of hydrocarbons, preferably methane, in the presence of CO | 2013-05-09 |
20130116117 | EXHAUST GAS PURIFYING CATALYST AND PRODUCTION METHOD FOR SAME - Disclosed is an exhaust gas purifying catalyst which includes barium hexaaluminate, and palladium and barium which are supported on barium hexaaluminate, wherein the amount of supported palladium, as reduced to metallic Pd, is 0.2 to 3.5 mass % with respect to the mass of barium hexaaluminate; the amount of supported barium, as reduced to BaO, is 1 to 20 mass % with respect to the mass of barium hexaaluminate; and the ratio by mole of supported barium to supported palladium, Ba/Pd, is (0.5 to 10)/1; an exhaust gas purifying catalyst product which has a catalyst support made of a ceramic or metallic material, and a layer which is formed of the exhaust gas purifying catalyst as a predominant component and which is supported on the catalyst support; and a method for producing the exhaust gas purifying catalyst product. | 2013-05-09 |
20130116118 | CATALYST COMPOSITION FOR THE STEAM REFORMING OF METHANE IN FUEL CELLS - The present invention relates to a catalyst composition and a catalyst material produced therefrom for the steam reforming of methane in fuel cells, in particular for the direct internal reforming of methane in molten carbonate fuel cells. The invention further relates to a process for producing such catalyst compositions. | 2013-05-09 |
20130116119 | COMPOSITIONS AND METHODS FOR ENHANCING PLANT QUALITY - Presented herein are compositions comprising an antioxidant (i), a radiation manager (ii), and one or more of, a plant strengthener (iii), or a plant growth regulator (iv). Also presented herein are compositions comprising a plant strengthener (iii), and one or more of, an antioxidant (i), or a radiation manager comprising a polyoxyalkylene UV absorber (ii). Furthermore, methods of using the disclosed compositions are also provided. | 2013-05-09 |
20130116120 | ALKOXYLATED ALKYLAMINES/ALKYL ETHER AMINES WITH PEAKED DISTRIBUTION - The present invention relates to processes for preparation of alkoxylated alkyl amines or alkoxylated alkyl ether amines with peaked distribution, surfactants comprising alkoxylated alkyl amines or alkoxylated alkyl ether amines with peaked distribution, and stable herbicidal formulations comprising alkoxylated alkyl amines or alkoxylated alkyl ether amines with peaked distribution. | 2013-05-09 |
20130116121 | METHOD FOR IMPARTING STRESS TOLERANCE TO PLANT, PLANT STRESS TOLERANCE IMPARTING COMPOSITION AND USE THEREOF - A method for imparting a stress tolerance to a plant that can provide the plant with such a stress tolerance that enhances growth in an environment where a variety of stresses on the plant occur is provided. The method for imparting a stress tolerance to a plant includes the step of applying, to a plant placed under a stressful cultivation condition that yields a plant stress level of 111 to 200%, a plant stress tolerance imparting composition containing at least one cellulose derivative selected from the group consisting of methyl cellulose (MC), hydroxymethyl cellulose (HMC), ethyl cellulose (EC), hydroxyethyl cellulose (HEC), propyl cellulose (PC), hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), hydroxyethyl methyl cellulose (HEMC), hydroxyethyl propyl cellulose (HEPC), methyl ethyl cellulose (MEC), methyl propyl cellulose (MPC) and ethyl propyl cellulose (EPC); catechins; and water, the cellulose derivative being contained in an amount of 45.0 to 99.5 wt % of the total components of the plant stress tolerance imparting composition except water. The present invention also provides the plant stress tolerance imparting composition and use of the plant stress tolerance imparting composition. | 2013-05-09 |
20130116122 | HOMOGENEOUS GAS-EVOLVING COMPOSITION - A homogeneous gas-evolving composition is provided that includes an acid, a gas-evolving acid neutralizing agent, and at least one of an inorganic carbonate, inorganic bicarbonate, alkaline peroxide, or alkaline azide. A water-soluble desiccant is homogeneously intermixed with the acid and the gas-evolving acid neutralizing agent. The desiccant is present in an amount able to absorb ambient moisture equivalent to at least 0.01 total weight percent of the composition before gas evolution of more than 50% of the theoretical gas evolution available from the composition. To confer storage stability, the acid, the gas-evolving acid neutralizing agent, and water-soluble desiccant cumulatively have a water content of less than 1 total weight percent water. Through appropriate selection of a desiccant or inclusion of a surfactant foaming agent, the composition foams upon drenching with water. The composition is particularly well suited for consistent usage of glyphosate herbicide. Plant growth inhibition is provided by wetting a plant with water and then applying the composition onto the plant. After allowing sufficient time, the composition absorbs the water and evolves gas, thereby spreading herbicide on the plant preferential to surrounding soil. | 2013-05-09 |
20130116123 | METHOD FOR PRE-EMERGENT WEED CONTROL USING TRIAZINE-BASED HERBICIDE - Methods for pre-emergent weed control using a triazine-based herbicide are disclosed. Particularly, methods of using ametryn as a pre-emergent herbicide to control weeds in corn crops are disclosed. | 2013-05-09 |
20130116124 | METHOD FOR CHANGING THE DEVELOPMENT PATTERN, INCREASING THE GROWTH AND THE ACCUMULATION OF STARCH, CHANGING THE STRUCTURE OF STARCH AND INCREASING THE RESISTANCE TO WATER STRESS IN PLANTS - The invention relates to a method for changing the development pattern, increasing the growth and starch accumulation, changing the structure of starch and increasing the resistance to water stress in plants. The method involves culturing plants in an atmosphere containing volatile elements emitted by a microorganism, without there being any physical contact between the microorganism and the plant. The method is based on the discovery that the volatile elements emitted by Gram-positive or Gram-negative bacteria, yeasts and microscopic fungi stimulate an increase in the growth of plants in general, with an increase in the height, the number of leaves and/or the number of branches of the plant, as well as an increase in the accumulated starch and structural change of this biopolymer, and modification of the development pattern, with an increase in floral buds. An increased resistance to water stress can also be observed, in addition to an increase in starch in leaves separated from whole plants. | 2013-05-09 |
20130116125 | NOVEL METHODS OF PROTEIN EVOLUTION - The present invention is relevant to proteins and novel methods of protein evolution. The present invention further relates to methods of identifying and mapping mutant polypeptides formed from, or based upon, a template polypeptide. | 2013-05-09 |
20130116126 | COMPOSITIONS AND METHODS FOR IDENTIFYING AND MODIFYING CARBONACEOUS COMPOSITIONS - This invention generally relates to natural gas and methylotrophic energy generation, bio-generated fuels and microbiology. In alternative embodiments, the invention provides nutrient amendments and microbial compositions, e.g., consortia, that are both specifically optimized to stimulate methanogenesis, or for “methylotrophic” or other conversions. In alternative embodiments, the invention provides methods to develop nutrient amendments and microbial compositions that are both specifically optimized to stimulate methanogenesis in a given reservoir. The invention also provides methods for the evaluation of potentially damaging biomass formation and scale precipitation resulting from the addition of nutrient amendments. In other embodiments, the invention provides methods for simulating biogas in sub-surface conditions using a computational model. | 2013-05-09 |
20130116127 | BREAST CANCER ASSOCIATED CIRCULATING NUCLEIC ACID BIOMARKERS - The invention provides methods and reagents for diagnosing breast cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated. | 2013-05-09 |
20130116128 | INTEGRATED SEQUENCING APPARATUSES AND METHODS OF USE - Provided are methods and apparatuses for performing sequencing using droplet manipulation, for example, via electrowetting-based techniques. Also provided are integrated methods and apparatuses for performing sample preparation and sequencing on the same apparatus. In addition, provided are methods of reducing reagent waste and preloaded consumable cartridges comprising reagents for sample preparation and/or sequencing. | 2013-05-09 |
20130116129 | METHOD FOR DETECTING TARGET MOLECULES - The present invention provides a method for detecting a target molecule using the sequence information of a collection (pool) of aptamers capable of specifically binding to a target molecule, comprising the following steps of: (a) bringing a target molecule into contact with a collection of oligonucleotides which comprise multiple nucleic acid aptamers having different randomized sequences; (b) selecting a subcollection of oligonucleotides that bind to the target molecule; (c) examining the sequence of each oligonucleotide of the selected subcollection; (d) extracting sequence information which is characteristic to the oligonucleotides having affinity for the target molecule, from the sequences of the selected oligonucleotides; and (e) identifying the target molecule based on the sequence information. | 2013-05-09 |
20130116130 | Digital Counting of Individual Molecules by Stochastic Attachment of Diverse Label-Tags - Compositions, methods and kits are disclosed for high-sensitivity counting of individual molecules by stochastic labeling of a identical molecules in mixtures of molecules by attachment of a unique label-tags from a diverse pool of label tags to confer uniqueness to otherwise identical or indistinguishable events. Individual occurrences of target molecules randomly choose from a non-depleting reservoir of diverse label-tags. Labeled molecules may be detected by hybridization or sequencing based methods. Molecules that would otherwise be identical in information content are labeled to create a separately detectable product that can be distinctly detected. The disclosed stochastic transformation methods reduce the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed label-tags are present. The methods may be used, for example, to count a given species of molecule within a sample. | 2013-05-09 |
20130116131 | METHODS AND MATERIALS FOR THE DIAGNOSIS OF PROSTATE CANCERS - Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including detecting the levels of expression of multiple polypeptide biomarkers in a biological sample obtained from the subject and comparing the levels of expression with predetermined threshold levels. Levels of expression of at least two of the polypeptide markers that are above the predetermined threshold levels are indicative of the presence of prostate cancer in the subject. Determination of the expression levels of specific combinations of biomarkers can also be used to determine the type and/or stage of prostate cancer. | 2013-05-09 |
20130116132 | ALZHEIMER'S PROBE KIT - Oligonucleotide probes for use in assessing gene transcript levels in a sample, which may be used in analytical techniques, particularly diagnostic techniques, are disclosed. Conveniently the probes are provided in kit form. Different sets of probes may be used in techniques to prepare gene expression patterns and identify, diagnose or monitor neurodegenerative diseases or conditions and their progression. | 2013-05-09 |
20130116133 | METHODS AND MATERIALS FOR THE DIAGNOSIS OF PROSTATE CANCERS - Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including detecting the levels of expression of multiple polypeptide biomarkers in a biological sample obtained from the subject and comparing the levels of expression with predetermined threshold levels. Levels of expression of at least two of the polypeptide markers that are above the predetermined threshold levels are indicative of the presence of prostate cancer in the subject. Determination of the expression levels of specific combinations of biomarkers can also be used to determine the type and/or stage of prostate cancer. | 2013-05-09 |
20130116134 | METHOD AND KIT FOR THE CLASSIFICATION AND PROGNOSIS OF WOUNDS - The invention relates to a method and kit for identifying chronic or acute mammalian wound tissue or for determining the prognosis of mammalian wound tissue based upon the identification of at least one key set of molecular markers or genes whose expression pattern is indicative of a given wound type and so representative of a given prognosis. | 2013-05-09 |
20130116135 | Methods, Kits and Reagents for Diagnosing, Alding Diagnosis and/or Monitoring Progression of a Neurological Disorder - The present inventors have identified a panel of biomarkers present in a biological sample of an individual (e.g. blood, including serum or plasma) whose concentrations or levels are altered in individuals with a neurological disorder. Accordingly, changes in the level of any one or more of these biomarkers can be used to assess cognitive function, to diagnose or aid in the diagnosis of a neurological disorder and/or to monitor a neurological disorder in a patient (e.g., tracking disease progression in a patient and/or tracking the effect of medical or surgical therapy in the patient). Changes in the level of any one or more of these biomarkers can also be used to stratify a patient (i.e., sorting an individual with a probable diagnosis of a neurological disorder or diagnosed with a neurological disorder into different classes of the disorder) and diagnosing or aiding in the diagnosis of mild cognitive impairment (MCI) as well as diagnosing or aiding in the diagnosis of cognitive impairment. | 2013-05-09 |
20130116136 | PROBES FOR GENOTYPING LOW-RISK-HPV - The current invention is concerned with a composition comprising at least one probe oligonucleotide each for the nucleotide sequences of the invention, said probe oligonucleotides specifically hybridizing to the sense strand or the antisense strand of said nucleotide sequences. Moreover, the present invention relates to a method for the identification of low-risk HPV types in a sample comprising the steps of a) contacting a sample with an amplification composition allowing amplification of at least one region of the HPV genome specifically hybridizing to at least one of the probe oligonucleotides of the current invention under conditions which allow for the amplification of polynucleotides and b) identifying low-risk HPV genotypes in said sample based on the amplified polynucleotides obtained in step a) by hybridizing the amplified polynucleotides with at least one labelled probe oligonucleotide of the current invention while said amplified polynucleotides are present in the same reaction container. The invention also relates to the use of a composition of the current invention for identifying low-risk HPV hi a sample and to a kit comprising the composition of the invention and/or adopted for carrying out the method of the invention and an instruction manual. | 2013-05-09 |
20130116137 | CANTILEVERED PROBE DETECTOR WITH PIEZOELECTRIC ELEMENT - A disclosed chemical detection system for detecting a target material, such as an explosive material, can include a cantilevered probe, a probe heater coupled to the cantilevered probe, and a piezoelectric element disposed on the cantilevered probe. The piezoelectric element can be configured as a detector and/or an actuator. Detection can include, for example, detecting a movement of the cantilevered probe or a property of the cantilevered probe. The movement or a change in the property of the cantilevered probe can occur, for example, by adsorption of the target material, desorption of the target material, reaction of the target material and/or phase change of the target material. Examples of detectable movements and properties include temperature shifts, impedance shifts, and resonant frequency shifts of the cantilevered probe. The overall chemical detection system can be incorporated, for example, into a handheld explosive material detection system. | 2013-05-09 |
20130116138 | PEPTIDE DOMAINS THAT BIND SMALL MOLECULES OF INDUSTRIAL SIGNIFICANCE - Described herein are small peptide domains and consensus sequences that bind small target molecules of industrial importance, e.g., metals such as nickel, β carotene, and isoflavones such as genistein. Also described are fusion proteins containing such binding domains fused to proteins or to peptide domains like GST or GBD that bind other ligands and can be used to immobilize the target binding domain on a support. One class of fusion proteins that is useful in industrial settings are fusions that contain concatemers of target binding domains, which increases the binding equivalents per molecule. | 2013-05-09 |
20130116139 | INNATE IMMUNITY MARKERS OF CANCER - This invention relates generally to methods of determing if a subject has a genetic predisposition to cancer, e.g., prostate cancer and breast cancer. | 2013-05-09 |
20130116140 | METHODS AND MATERIALS FOR DETERMINING THE EFFICACY OF PROSTATE CANCER THERAPIES - Methods for monitoring, and determining the efficacy of, a treatment for prostate cancer in a subject are provided, such methods including detecting the levels of expression of multiple polypeptide biomarkers in biological samples obtained from the subject prior to, and during, a course of treatment. Specific patterns of changes in the expression of the polypeptide biomarkers are indicative of the effectiveness of the treatment in the subject. | 2013-05-09 |
20130116141 | Systems and Methods for Multiplex Analysis of PCR in Real Time - The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the PCR process. | 2013-05-09 |
20130116142 | METHODS AND MATERIALS FOR THE DIAGNOSIS OF PROSTATE CANCERS - Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including detecting the levels of expression of multiple polypeptide biomarkers in a biological sample obtained from the subject and comparing the levels of expression with predetermined threshold levels. Levels of expression of at least two of the polypeptide markers that are above the predetermined threshold levels are indicative of the presence of prostate cancer in the subject. Determination of the expression levels of specific combinations of biomarkers can also be used to determine the type and/or stage of prostate cancer. | 2013-05-09 |
20130116143 | DETECTION AND ANALYSIS OF EPIGENETIC AND GENETIC CHANGES IN TUMOR TISSUE - The invention generally relates to a novel method and related compositions for detecting and analyzing cancer. More particularly, the invention relates to unique methods, compositions and assays useful for diagnosing and measuring the presence and/or risk of ovarian cancer involving the utilization of various generic and epigenetic biomarkers. | 2013-05-09 |
20130116144 | METHYLATION MARKER FOR DIAGNOSIS OF CERVICAL CANCER - The present invention relates to a cervical cancer-specific methylation marker for diagnosis of cervical cancer, and more particularly, to a cervical cancer-specific methylation marker, the CpG island region of which is methylated specifically in cervical cancer cells. The use of the kit and nucleic acid chip for diagnosis of cervical cancer of the present invention enables diagnosis of cervical cancer at an initial transformation stage, thus making it possible to diagnose cervical cancer at an early stage. In addition, the invention makes it possible to predict progression for high-risk groups and screen cervical cancer in a more accurate and rapid manner compared to conventional methods. | 2013-05-09 |
20130116145 | DIAGNOSIS AND PROGNOSIS OF BREAST CANCER PATIENTS - The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein. | 2013-05-09 |
20130116146 | Peptide Microarray and Method of Use - A peptide microarray comprising a plurality of predicted unique binding peptides being selected by computational prediction of interaction with a protein of interest or a domain thereof. The selected unique binding peptides are pre-synthesized and then printed and/or immobilized onto a solid support surface via N-terminus with a linker. Methods of using the invention peptide microarray for quantitative determination of protein-peptide interaction, epitope mapping, and drug screening are also provided. | 2013-05-09 |
20130116147 | DNA METHYLATION BIOMARKERS FOR LUNG CANCER - The present invention relates to the identification of novel DNA biomarkers and the use of the aberrant methylation patterns of the biomarkers to diagnose a disease or a condition (e.g., a cancer) associated therewith. In particular, the present invention relates to the use of the novel DNA biomarkers to diagnose lung cancers, e.g., squamous cell carcinomas and adenocarcinomas. | 2013-05-09 |
20130116148 | LIVER DISEASE MARKER, METHOD AND APPARATUS FOR MEASURING THE SAME, AND METHOD FOR ASSAYING PHARMACEUTICAL PREPARATION - Disclosed is a method for promptly identifying a liver disease. A normal person or a liver disease such as drug-induced liver injury, asymptomatic hepatitis B carrier, chronic hepatitis B, hepatitis C with persistently normal ALT, chronic hepatitis C, cirrhosis type C, hepatocellular carcinoma, simple steatosis, or non-alcoholic steatohepatitis is identified by measuring the concentration of a γ-Glu-X (wherein X represents an amino acid or an amine) peptide or the level of AST or ALT in blood and carrying out, for example, a multiple logistic regression based on the measured value. | 2013-05-09 |
20130116149 | Genetic Markers Associated with Intellectual Disability - Genetic markers associated with intellectual disability as well as compositions, methods and kits for screening for genetic markers intellectual disability, diagnosing intellectual disability and identifying individuals with a predisposition for offspring suffering from intellectual disability are provided. | 2013-05-09 |
20130116150 | Lung Cancer Biomarkers and Uses Thereof - The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 18, Table 20, or Table 21, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value. | 2013-05-09 |
20130116151 | BIOMARKER FOR HYPERTENSIVE DISORDERS OF PREGNANCY - The application discloses a new tool for predicting, diagnosing and prognosing hypertensive disorders of pregnancy and particularly preeclampsia; methods for the diagnosis, prediction, prognosis and/or monitoring said disorders; and kits and devices for measuring said biomarker and/or performing said methods. | 2013-05-09 |
20130116152 | UBIQUITINATION ASSAY - The present application relates to a method of assaying ubiquitination in a sample by combining ubiquitin together with a substrate in a sample containing UBE1, UbcH3, Skp2-isoform 1, Skp1, Cul1, Rbx1, Cks1, CDK2 and Cyclin E1 under conditions suitable for ubiquitination to take place, exposing the sample to a labelled binding partner which is specific for the ubiquitin, and measuring the amount of ubiquitin bound to the substrate. | 2013-05-09 |
20130116153 | MICROARRAY FABRICATION SYSTEM AND METHOD - A microarray is designed capture one or more molecules of interest at each of a plurality of sites on a substrate. The sites comprise base pads, such as polymer base pads, that promote the attachment of the molecules at the sites. The microarray may be made by one or more patterning techniques to create a layout of base pads in a desired pattern. Further, the microarrays may include features to encourage clonality at the sites. | 2013-05-09 |
20130116154 | METHOD AND SUBSTANCES FOR ISOLATION AND DETECTION OF SMALL POLYNUCLEOTIDES - A capture probe suitable for use with methods for isolating, labeling or detecting small polynucleotides. A method for isolating a small polynucleotide of interest from a sample comprising hybridizing the small polynucleotide to the capture probe and lengthening the small polynucleotide by primer extension or ligation. A method for detecting a small polynucleotide of interest following isolation by amplification of the primer extension products and/or hybridization and subsequent cleavage of dual labeled detector probes. | 2013-05-09 |
20130116155 | ANTICORROSIVE COMPOSITION BASED ON CHLORIDE IONS - The present invention relates to a powdery composition comprising a chloride selected from sodium chloride, magnesium chloride, calcium chloride, potassium chloride and mixtures thereof; metal particles of zinc and/or of aluminium and/or a metal salt; and optionally another corrosion inhibitor, and its method of preparation. It also relates to the use of metal particles in such compositions to protect steel or iron structures against the corrosion induced by chloride ions. | 2013-05-09 |
20130116156 | CHEMICAL SEAL RING COMPOSITION AND METHOD OF USING - Disclosed herein is a chemical seal ring composition that includes polyacrylamide crosslinked with a non-metallic crosslinker such as polylactam. Also, described in a method of forming a chemical seal ring from the chemical seal ring composition. | 2013-05-09 |
20130116157 | SLIDING MATERIAL BASED ON GRAPHITE-ADDED RESIN AND SLIDING MEMBER - [Task] Seizure resistance of sliding material based on graphite-added resin is improved. | 2013-05-09 |
20130116158 | LUBRICANT COMPOSITIONS AND ROLLING DEVICE - The lubricant compositions of the invention include a saturated fatty acid triglyceride as a lubricating ingredient and further contain an antioxidant or a thickener which is magnesium stearate or calcium stearate. Consequently, the lubricant compositions are harmless even when eaten, have excellent lubricity, and impose little burden on the environment. The rolling device of the invention not only imposes little burden on the environment because the device is lubricated with either of these lubricant compositions, but also has excellent durability. | 2013-05-09 |
20130116159 | PHOTORESIST AND POST ETCH RESIDUE CLEANING SOLUTION - A photoresist and post etch cleaning solution for semiconductor wafers comprising:
| 2013-05-09 |
20130116160 | NOVEL WHITENING AGENTS FOR CELLULOSIC SUBSTRATES - This invention relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two components: at least one chromophore component and at least one polymeric component. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to ultraviolet light, or they may absorb light to reflect these same shades. The whitening agents are further characterized by having a dispersion component value of the Hansen Solubility Parameter of less than or equal to about 17 MPa | 2013-05-09 |
20130116161 | Composition - A cleaning composition comprises a dispersion. The dispersion includes an acidic aqueous phase and a suspended particle. The particle is coated with an acid stable coating. The particle comprises an admixture of tetraacetylethylenediamine (TAED) and decanoyloxybenzenecarboxylic acid (DOBA). | 2013-05-09 |
20130116162 | ENZYME CLEANING COMPOSITION AND METHOD OF USE - A cleaning composition for treating a surface comprises a purified enzyme and an enzyme denaturant system. The enzyme denaturant system is configured to denature the purified enzyme such that any residue remaining on the surface after the treatment of the surface is virtually free of active purified enzymes. | 2013-05-09 |
20130116163 | USE OF QUATERNARY AMMONIUM COMPOUND AS A HYDROTROPE AND A COMPOSITION CONTAINING THE QUATERNARY AMMONIUM COMPOUND - The present invention relates to the use of an alkyl di(lower alkyl)mono(polyoxyethylene) quaternary ammonium compound as a hydrotrope in 5 aqueous solutions for a nonionic surfactant, preferably a C8-C18-alcohol alkoxylate containing 1-20 ethyleneoxy units and 0-5 propyleneoxy units. It also relates to a composition comprising said quaternary ammonium compound and said nonionic surfactant. The cationic surfactant has the formula 10 R2+R(1)N(CH2CH2O)n H X R1 wherein R═C6-C22 alkyl; R1 and R2 are independently a C1-C4 alkyl group; n=8-25; and X— is an anion. The compositions may be used for the cleaning of hard surfaces, for example for vehicle cleaning or machine dishwashing. | 2013-05-09 |
20130116164 | PROCEDURE FOR CONDITIONING AND PERFUMING TREATMENT FOR TEXTILE ITEMS AFTER RINSING AND THE PRODUCT USED IN THIS PROCEDURE - The invention comprises a procedure for conditioning and perfuming textiles and a product suitable for carrying out this procedure, with a long-lasting persistence of the perfuming effect in the garments. The procedure comprises the phases for obtaining a solid product that comprises a hydrosoluble core and an enveloping layer composed by at least one water-soluble softening active ingredient. These ingredients have water-soluble surface activity, adjuvants and perfumes. The procedure also includes the phases of dosing the solid treatment product at a concentration between 0.2 and 15 g/1 of treatment liquid, the application of the solid and the washing water in rinsing phase at pH between 3 and 10. | 2013-05-09 |
20130116165 | LIGHT-ACTIVATED FUSION PROTEINS AND USES THEREFOR - The invention, in some aspects relates to synthetic, light-activated fusion proteins and their encoding polynucleotide molecules. In some aspects the invention additionally includes expression of the light-activated fusion proteins in cells and their use in methods such as therapeutic methods and candidate compound screening methods. | 2013-05-09 |
20130116166 | BIOMARKERS FOR IDIOPATHIC PULMONARY FIBROSIS - Biomarkers, kits, and diagnostic and treatment methods for idiopathic pulmonary fibrosis are provided. | 2013-05-09 |
20130116167 | ANTI-MART-1 T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE - The invention provides a chimeric T cell receptor (TCR) comprising a variable region of a human TCR and a constant region comprising at least an extracellular domain of a constant region of a non-human TCR, as well as functional variants thereof. The invention also provides polypeptides and proteins related to the inventive TCRs, as well as nucleic acids encoding the TCRs, polypeptides, or proteins, recombinant expression vectors, and host cells. Further provided are pharmaceutical compositions related to the inventive TCRs and methods of preventing or treating a disease, e.g., an infectious disease, cancer, in a host, methods of detecting a diseased cell in a host, and methods of improving the biological activity of a TCR. | 2013-05-09 |
20130116168 | PEA PROTEIN PEPTIDES WITH ANTI HELICOBACTER PYLORI ACTIVITY - The invention relates to a composition comprising pea protein hydrolysate for the treatment and/or prevention of infection by gastrointestinal pathogens, in particular | 2013-05-09 |
20130116169 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE - The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds. | 2013-05-09 |
20130116170 | CONTROL OF COLEOPTERAN INSECT PESTS - Improved compositions and methods for controlling coleopteran pests are disclosed. In particular, novel combinations of insecticidal proteins having improved toxicity to coleopteran insect pests such as corn rootworm are provided. Further, a method of killing or controlling coleopteran insect pests using the compositions of the invention is disclosed. | 2013-05-09 |
20130116171 | METHODS FOR TREATING METABOLIC DISORDERS USING FGF - The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance, dyslipidaemia, obesity, and fatty liver. | 2013-05-09 |
20130116172 | GLUCAGON SUPERFAMILY PEPTIDES EXHBITING G PROTEIN COUPLED RECEPTOR ACTIVITY - Provided herein are glucagon superfamily peptides conjugated with GPCR ligands that are capable of acting at a G protein-coupled receptor. Also provided herein are pharmaceutical compositions and kits of the conjugates of the invention. Further provided herein are methods of treating a disease, e.g., a metabolic disorder, such as diabetes and obesity, comprising administering the conjugates of the invention. | 2013-05-09 |
20130116173 | Glucagon Analogs Exhibiting GIP Receptor Activity - Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity. In exemplary embodiments, the glucagon analog of the present disclosures exhibit an EC50 at the GIP receptor which is within the nanomolar or picomolar range. | 2013-05-09 |
20130116174 | COMPOSITIONS AND METHODS FOR INCREASING POULTRY HATCHABILITY AND EARLY PERFORMANCE - Compositions and methods of improving poultry hatch health are provided herein. Poultry hatch health and hatchability may be improved by administering compositions in ovo prior to hatch. The compositions include iodinated tyrosine-containing proteins, suitably iodinated casein, and carbohydrates. | 2013-05-09 |
20130116175 | REVERSIBLE PEGYLATED DRUGS - Reversible pegylated drugs are provided by derivatization of free functional groups of the drug selected from amino, hydroxyl, mercapto, phosphate and/or carboxyl with groups sensitive to mild basic conditions such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS), to which group a PEG moiety is attached. In these pegylated drugs, the PEG moiety and the drug residue are not linked directly to each other, but rather both residues are linked to different positions of the scaffold Fmoc or FMS structure that is highly sensitive to bases and is removable under physiological conditions. The drugs are preferably drugs containing an amino group, most preferably peptides and proteins of low or medium molecular weight. Similar molecules are provided wherein a protein carrier or another polymer carrier replaces the PEG moiety. | 2013-05-09 |
20130116176 | DERIVATISATION OF ERYTHROPOIETIN (EPO) - The present invention relates to a compound which is a polysaccharide derivative of EPO, or of an EPO like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units. The present invention also relates to pharmaceutical compositions comprising the novel compounds, and methods for making the novel compounds. | 2013-05-09 |
20130116177 | USE OF AROMATASE INHIBITORS FOR SYNCHRONIZING OVULATION, INDUCING SUPEROVULATION OR DOUBLE OVULATION AND IMPROVING TWINNING AND FERTILITY IN A MAMMAL - Described herein are methods for synchronizing ovulation in a herd, inducing superovulation in a single animal, and improving frequency of successful implantation and development of fertilized ova. | 2013-05-09 |
20130116178 | PHARMACEUTICAL COMPOSITIONS COMPRISING POLYETHYLENE GLYCOL HAVING A MOLECULAR WEIGHT OF LESS THAN 600 DALTONS - A liquid pharmaceutical composition comprising a biodegradable polymer, polyethylene glycol having a molecular weight of less than 600 Daltons, a pharmaceutically active agent and less than 0.5% of an biologically acceptable organic solvent. | 2013-05-09 |
20130116179 | PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF A NEURODEGENERATIVE DISEASE - The present invention refers to a pharmaceutical composition for use in the treatment of a neurodegenerative disease. | 2013-05-09 |
20130116180 | PARATHYROID HORMONE ANALOGS AND USES THEREOF - Disclosed are two PTH analog ligands, SP-PTH-AAK and Aib-SP-PTH-AAK, that have long-acting activity at the PTH receptor, as demonstrated both in vitro and in vivo. These polypeptides are thus particularly useful in the treatment of diseases, such as hypoparathyroidism, in which long-acting activity is desired. The method of making the analog polypeptides is also disclosed. | 2013-05-09 |
20130116181 | Method of treating dyspnea associated with acute heart failure - The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin. | 2013-05-09 |
20130116182 | Factor VIII B Cell Epitope Variants Having Reduced Immunogenicity - Provided herein are methods and compositions for preventing or reducing an initial immune response to factor VIII in patients suffering from hemophilia A, and for reducing the intensity of the immune response in patients having pre-formed inhibitor antibodies against factor VIII. | 2013-05-09 |
20130116183 | PEPTIDES THAT INHIBIT ANGIOTENSIN CONVERTING ENZYME AND PEPTIDES WITH ANTIOXIDANT ACTIVITY PURIFIED FROM OVOTRANSFERRIN AND METHODS OF PRODUCING AND USING THE SAME - Described herein are methods of identifying and releasing bioactive peptides from ovotransferrin The method involves (a) contacting ovotransferrin with a reducing agent, a sonication step, a high pressure processing step, a heating step, a fermentation step, or any combination thereof, and (b) contacting the ovotransferrin after step (a) with a hydrolytic enzyme to produce bioactive peptides that exhibit angiotensin converting enzyme inhibitory activity or antioxidant activity when compared to the parent protein. The bioactive peptides may be added to foodstuffs, a medication, or to any potable, ingestible, or edible compositions. | 2013-05-09 |
20130116184 | RFamide-Related Peptides and Methods Thereof - Provided herein methods and compositions directed to RFRP-1 polypeptides for modulating cardiac contractile function, for preventing and/or treating cardiac disorders. | 2013-05-09 |
20130116185 | PHOSPHATIDYLINOSITOL 3-KINASES ACTIVITY REGULATOR INCLUDING THE FIFTH ZINC FINGER DOMAIN OF FOG2 - The present invention relates to a phosphatidylinositol 3-kinases activity regulator which include the fifth zinc finger domain of FOG2 and which, more specifically, can induce cancer cells to die due to the inclusion of the fifth zinc finger domain of FOG2. Since the death of cancer cells is induced by suppressing the transfer of PI3K signals, the fifth zinc finger domain of FOG2 according to the present invention can be suitably use as a composition for the prevention and treatment of PI3K-related diseases. | 2013-05-09 |
20130116186 | LUBRICIN INJECTIONS TO MAINTAIN CARTILAGE HEALTH - Disclosed are novel methods of maintaining articular cartilage health in an atraumatic, non-diseased joint of a mammal, either human or non-human. The methods involve injecting into the joint capsule of the mammal an amount of a lubricin polypeptide to prevent shear-induced chondrocyte apoptosis and to maintain a lubricin-expressing phenotype of chondrocytes. | 2013-05-09 |
20130116187 | ARTIFICIAL CARTILAGE AND ITS PRODUCTION METHOD - An artificial cartilage comprising 15-95% by mass of collagen, 4.9-70% by mass of proteoglycan, and 0.1-20% by mass of hyaluronic acid. | 2013-05-09 |
20130116188 | IMPLANTABLE HYALURONIC ACID/COLLAGEN COMPOSITIONS - Hyaluronic acid and collagen may be crosslinked in aqueous solution as described herein. The crosslinked macromolecular matrices obtained in this process may be used as a hydrogel for implants and fillers for human aesthetic and therapeutic products. | 2013-05-09 |
20130116189 | RETINOL-MODIFIED COLLAGEN, METHOD FOR PRODUCING SAME, AND EXTERNAL COMPOSITION FOR SKIN CONTAINING SAME - Disclosed is a compound which exhibits a higher effect of preventing wrinkle formation, a higher effect of improving wrinkles, a higher effect of making the skin beautiful, and a higher effect of improving skin quality than conventional retinol and retinol derivatives in a sustained manner. Further disclosed are a method for producing the same, and an external composition for the skin and a sheet-shaped cosmetic each containing the same as an active ingredient. More specifically disclosed are retinol-modified collagen in which a dicarboxylic acid is attached to at least one hydroxyl group of collagen and retinol is attached to a carboxyl group of at least one attached dicarboxylic acid, a method for producing the same, and an external composition for the skin and a sheet-shaped cosmetic each containing the same as an active ingredient. | 2013-05-09 |
20130116190 | HYALURONIC ACID-COLLAGEN MATRICES FOR TISSUE ENGINEERING - Hydrogels comprising a macromolecular matrix including a crosslinked combination of hyaluronic acid and collagen, are provided for tissue engineering applications. | 2013-05-09 |
20130116191 | TRANSPORT PROTEIN WHICH IS USED TO INTRODUCE CHEMICAL COMPOUNDS INTO NERVE CELLS - The invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by | 2013-05-09 |
20130116192 | N-(AMINOACYL)-AMINO COMPOUND - N-(aminoacyl)-amino compound, represented by the following formula | 2013-05-09 |
20130116193 | USE OF THE PAT NONAPEPTIDE IN TREATING AND PREVENTING NEURODEGENERATIVE DISEASES - The invention relates to the use of the PAT nonapeptide in the manufacture of a drug for preventing or treating a neurodegenerative disease such as Alzheimer's disease. The parenteral route of administration is preferable, including the subcutaneous, intraperitoneal, intravenous or intranasal routes. The invention also relates to an injectable formulation containing the PAT nonapeptide which can be administered to patients suffering from a neurodegenerative disease such as Alzheimer's disease. | 2013-05-09 |