19th week of 2009 patent applcation highlights part 41 |
Patent application number | Title | Published |
20090117593 | T. Cruzi-derived neurotrophic agents and methods of use therefor - The invention relates to | 2009-05-07 |
20090117594 | METHOD FOR MEASURING HUMAN MEGALIN - This invention provides a method for measuring human megalin that can be performed in a simpler manner within a shorter period of time than is possible with conventional techniques, and that can also quantify human megalin. This invention also provides a method that enables diagnosis of functional diseases, which are specific to cells, tissues, or organs, in a site-directed manner at an early stage. Measurement of human megalin enables detection of a disease in an organ in which megalin expression is observed. | 2009-05-07 |
20090117595 | PRIMARY CENTRAL NERVOUS SYSTEM TUMOR SPECIFIC BEHAB ISOFORMS - The present invention comprises compositions and methods related to a glycosylation-variant BEHAB protein, poly-sialyated full-length BEHAB, and methods of use thereof. | 2009-05-07 |
20090117596 | Antibody-Sensitized Latex - Antibody-sensitized latex for use in determination of a bacterium belonging to the genus | 2009-05-07 |
20090117597 | Method for Measuring Heptoglobin Level in Blood Serum and Kit Therefor - The present invention relates to a method for measuring heptoglobin level in blood serum by using antibodies for α and β subunits of heptoglobin, and a kit for immunodetection of heptoglobin which comprises the antibodies for α and β subunits of heptoglobin for measuring heptoglobin level in blood serum. A method for measuring heptoglobin level in blood serum of the present invention comprises the steps of: reacting blood serum of a subject with an antibody (αh antibody) which binds specifically to α subunit of a dimeric heptoglobin and an antibody (βh antibody) which binds specifically to β subunit of a dimeric heptoglobin; and, measuring level of proteins which react with the αh antibody and βh antibody in blood serum and have a molecular weight of more than 100 kDa. The method for measuring heptoglobin level in blood serum can be practically applied for the early diagnosis of diseases which disrupt erythrocytes, since only the level of normal heptoglobin except for monomelic and degraded hep-toglobins can be specifically measured by the said method. | 2009-05-07 |
20090117598 | Method for identifying compounds that affect a transport of a protein through a membrane trafficking pathway - The present invention relates to a method for identifying compounds that affect a transport of a receptor of interest through a specific membrane trafficking pathway mediated by said receptor within the context of a generic membrane trafficking pathway, which generic pathway is not mediated by said receptor, characterised by the following steps:
| 2009-05-07 |
20090117599 | METHOD OF DETECTING SUGAR CHAINS HAVING GlcNAc TRANSFERRED BY GnT-V - It is intended to provide a method by which sugar chains having GlcNAc transferred by GnT-V can be accurately detected, screened and purified. In this detection method, two kinds of lectins differing in detailed GlcNAc-specificity are used together. As shown in FIG. | 2009-05-07 |
20090117600 | Detection of biological molecules by differential partitioning of enzyme substrates and products - This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples. | 2009-05-07 |
20090117601 | METHODS AND COMPOSITIONS FOR THE DETECTION OF BETA-LACTAMASES - Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases. AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes. | 2009-05-07 |
20090117602 | Plasmodium Diagnostic Assay Device - This invention relates to assays for a | 2009-05-07 |
20090117603 | STERILIZATION INDICATOR - The disclosed technology relates to a sterilization indicator and a process to concentrate signal generated by constraining it to a minimal surface, in a minimal volume and minimal pH and growth buffering or mediating influences. The sterilization indicator may comprise a carrier | 2009-05-07 |
20090117604 | PROTEOLYTIC ENZYMES IN URINE AS DIAGNOSTIC PARAMETERS IN DISEASES INVOLVING MATRIX REMODELLING - The present invention relates to a method for determining whether a urine sample has been obtained from a subject suffering from a kidney disorder involving kidney damage. The method is based on determining the level of a proteolytic enzyme in urine from the subject sample and optionally comparing this level with a reference value. The proteolytic enzyme preferably is a matrix metalloproteases, in particular MMP-2 or MMP-9. The method is particularly suitable for subjects with a condition or disorder that is associated with an increased risk of kidney disorders, such as diabetes. The method may advantageously be applied for early detection of kidney damage, in particular when the subject does not yet show any sign of microalbuminuria. The method may also be applied to a subject undergoing dialysis for determining whether the subject is suffering from remodelling of the peritoneal membrane. Thus, the method is particularly suited for patients undergoing continuous ambulatory peritoneal dialysis. | 2009-05-07 |
20090117605 | Software integrated cytometric assay for quantification of the human polymorphonuclear leukocyte fctri receptor (CD64) - The invention relates a method of quantifying CD64 and CD163 expression in leukocytes and, specifically to a kit for use with a flow cytometer including a suspension of quantitative fluorescent microbead standards, fluorescent labeled antibodies directed to CD64 and CD163, and analytical software. The software is used to take information on the microbead suspension and fluorescent labeled antibodies from a flow cytometer and analyse data, smooth curves, calculate new parameters, provide quality control measures and notify of expiration of the assay system. | 2009-05-07 |
20090117606 | Measuring Nanoparticle Concentrations in Tissue Using Diffuse Optical Spectroscopy - A non-invasive method to measure metal nanoparticle concentrations in bulk tissue is provided. A simple diagnostic assay to detect nanoparticle concentration in bulk tissue has been developed herein. One such provided method comprises: applying diffuse optical spectroscopy to a tissue having nanoparticles disposed therein; and applying an inverse algorithm to the light reflected from the nanoparticles. Another such method comprises: exposing tissue that comprises nanoparticles to a light source; collecting light from the tissue using an optical fiber probe; and measuring the concentration of nanoparticles in the tissue. A system is provided comprising: a tissue comprising nanoparticles; a light source arranged to illuminate a portion of the tissue; an optical fiber probe to collect light reflected from the tissue; and a spectrometer to measure the light reflected from the nanoparticles and operably connected to a computer having one or more processors and a memory. | 2009-05-07 |
20090117607 | Methods For Differential Detection Of Hypoxic Tissue From A Tissue Sample Of A Mammalian Subject - Methods are provided for detecting levels of low oxygen in a tissue of a mammalian subject by administering non-polar halogen compounds to the mammalian subject. Detection may be accomplished using imaging methods involving fluorescence immunohistochemical imaging of the halogen compound. | 2009-05-07 |
20090117608 | APPARATUS FOR ON-SITE MICROBIAL DIAGNOSIS AND DISINFECTION AND METHOD THEREFOR - An apparatus for on-site microbial diagnosis and disinfection comprising a mobile unit for being brought to an infected site in the event of an emergency. The mobile unit comprises at least a first compartment and a second compartment. The first compartment comprises a laboratory for on-site microbial diagnosis of samples of the site. The second compartment comprises a water supply for washing the site and a disinfectant supply for disinfecting the site. A method comprising on-site evaluation of the biological security of a microbiologically contaminated site and of the washing requirements of the site followed by sampling and on-site diagnosis the sample. A disinfection protocol is provided on-site and then applied, the efficacy of the protocol is later evaluated. Bacterium which are competitors to the identified microbiological agent or agents responsible for contamination or infection are then applied to the site. | 2009-05-07 |
20090117609 | USE OF TETRACYSTEINE TAGS IN FLUORESCENCE-ACTIVATED CELL SORTING ANALYSIS OF PROKARYOTIC CELLS PRODUCING PEPTIDES OR PROTEINS - A process of in vivo labeling and identifying recombinantly produced peptides or proteins within an unpermeabilized prokaryotic host cell. Recombinant prokaryotic cells expressing a fusion peptide comprising at least one tetracysteine tag were labeled in vivo using a biarsenical labeling reagent. A fluorescent activated cell sorter was used to identify and select subpopulations of fluorescent cells wherein the amount of fusion peptide in the cell was proportional to the amount of fluorescence detected. | 2009-05-07 |
20090117610 | Methods and Compositions for Identifying a Cell Phenotype - A method of staining or pre-staining at least one cell is provided. The method comprising contacting the at least one cell with a staining agent selected from the group consisting of an extract of a | 2009-05-07 |
20090117611 | DEVICE AND METHOD FOR WETTING OBJECTS - The invention relates to a device and a method for wetting objects with a liquid by means of a system for carrying a specimen slide that is disposed at a distance from a platform. To reduce liquid consumption, the specimen slide is raised or lowered relative to the platform by means of a system. | 2009-05-07 |
20090117612 | METHOD OF BIOOXIDATION USING AN OLD YELLOW ENZYME - A method for a chemoselective and regioselective enzyme mediated oxidation of carbon-hydrogen bonds of substrates using a | 2009-05-07 |
20090117613 | Method for redox reaction using an old yellow enzyme - A method of selective biooxidation to non activated carbon-hydrogen bonds of substances using a | 2009-05-07 |
20090117614 | BETA-MANNANASE FROM COFFEE BERRY BORER, HYPOTHENEMUS HAMPEI, AND USES THEREOF - The present invention relates to an isolated β-mannanase protein having an amino acid sequence which is 90% similar to the amino acid sequence of SEQ ID NO: 1, as well as isolated polynucleotides encoding the β-mannanase protein, and isolated expression systems and host cells containing the polynucleotides. The present invention also relates to a method of recombinantly producing β-mannanase protein. Also disclosed is a method of degrading mannans and polysaccharides in plant material, which involves providing plant material and contacting the plant material with the β-mannanase protein of the present invention under conditions effective to degrade mannans and polysaccharides in the plant material. | 2009-05-07 |
20090117615 | Recombinant mammal cells, method of producing thereof, and method of producing proteins of interest - The present invention relates to a method of expressing an objective protein at a high level and stably as well as for a long period even in the absence of a selection drug with a recombinant mammal cell. More particularly, the present invention relates to a method of producing an objective protein by providing a recombinant mammal cell having multiple copies of the exogenous objective protein gene expression unit integrated into a hypoxanthine-phosphoribosyl transferase enzyme (hprt) gene locus and culturing said cell. | 2009-05-07 |
20090117616 | Methods for reducing or eliminating alpha-mannosidase resistant glycans for the production of glycoproteins - The present invention provides methods to reduce or eliminate α-mannosidase resistant glycans on glycoproteins in yeast. The reduction or elimination of α-mannosidase resistant glycans on glycoproteins results from the disruption of the newly isolated | 2009-05-07 |
20090117617 | Methods and compositions for targeted integration - Disclosed herein are methods and compositions for targeted integration of one or more copies of a sequence of interest using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain and integrase defective lentiviral donor constructs. | 2009-05-07 |
20090117618 | Expression system for preparing IL-15/FC fusion protein and its use - The invention relates to an expression system containing one or more nucleic acid(s) comprising at least one nucleic acid for an interleukin 15/Fc (IL-15/Fc) fusion protein, at least one promotor, at least one nucleic acid for a CD5 leader and, where appropriate, at least one nucleic acid for a selectable marker gene; to a nucleic acid comprising the components of the said expression system and to a host cell containing the expression system or the nucleic acid. Furthermore, the invention relates to a process for preparing an IL-15/Fc fusion protein, using the expression system, and to the use of the expression system, the nucleic acid, the host cell or the CD5 leader for expression in host cells. | 2009-05-07 |
20090117619 | CARBOHYDRASE EXPRESSION DURING DEGRADATION OF WHOLE PLANT MATERIAL BY SACCHAROPHAGUS DEGRADANS - The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose, hemicellulose and other carbohydrates. These systems have a number of applications. | 2009-05-07 |
20090117620 | AUTOMATED ANALYZER FOR CLINICAL LABORATORY - A laboratory automation system that is capable of carrying out clinical chemistry assays, immunoassays, amplification of nucleic acid assays, and any combination of the foregoing, said laboratory automation system employing at least one of micro-well plates and deep multi-well plates as reaction vessels. The use of micro-well plates as reaction vessels enables the laboratory automation system to assume a variety of arrangements, i.e., the laboratory automation system can comprise a variety of functional modules that can be arranged in various ways. In order to effectively carry out immunoassays by means of micro-well plates, a technique known as inverse magnetic particle processing can be used to transfer the product(s) of immunoassays from one micro-well of a micro-well plate to another. | 2009-05-07 |
20090117621 | Methods of nucleic acid amplification and sequencing - The invention relates to a method of amplifying one or more nucleic acid templates on a solid support in a nucleic acid amplification reaction, for example by solid-phase PCR using one or more amplification primers attached to the solid support. The method is characterised in that the amplification primers used comprise a template-specific portion which is a sequence of at least 26 consecutive nucleotides and are not capable of annealing to target regions in the template under conditions of the amplification reaction. The method is particularly useful for amplifying human genomic DNA. | 2009-05-07 |
20090117622 | MIXTURE OF REVERSIBLY INHIBITED ENZYMES - The invention relates to composition or a kit containing an enzyme that is reversibly inhibited by means of a chemical modification and an enzyme which is reversibly inhibited using non-covalent binding, the use of a mixture of enzymes reversibly inhibited in such a manner for processing or multiplying polynucleotides, and a method for specifically amplifying DNA by simultaneously using both types of reversibly inhibited enzymes. | 2009-05-07 |
20090117623 | METHOD FOR PRODUCING L-AMINO ACIDS BY FERMENTATION USING BACTERIA HAVING ENHANCED EXPRESSION OF XYLOSE UTILIZATION GENES - A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genus | 2009-05-07 |
20090117624 | Process for the fermentative preparation of organic chemical compounds using coryneform bacteria in which the SugR gene is present in attenuated form - The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds. | 2009-05-07 |
20090117625 | Polypeptides and Biosynthetic Pathways for the Production of Monatin and Its Precursors - Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions. | 2009-05-07 |
20090117626 | Process for preparing carboxylic acid using surfactant-modified enzyme - The present invention relates to a process for preparing a carboxylic acid using a surfactant-modified enzyme which comprises selectively reacting water and a carboxylic acid ester, provided that triglyceride is excluded, in an organic solvent in the presence of a surfactant-modified enzyme. | 2009-05-07 |
20090117627 | PROCESS FOR PREPARING ENANTIOMERICALLY ENRICHED AMINES - A process for preparing enantiomerically enriched amines by reacting a ketone with ammonia or an ammonium salt and a reducing agent in the presence of a catalytic system comprising the components:
| 2009-05-07 |
20090117628 | Enzymatic processing in deep eutectic solvents - It has surprisingly been discovered that it is possible to use enzymes in deep eutectic solvents (DES). DES's are mixtures of a nitrogen salt or a metal salt and a strong hydrogen bond donor that can be mixed in proportions that form a eutectic point. | 2009-05-07 |
20090117629 | ISOPRENOID WAX ESTER SYNTHASES, ISOPRENOID ACYL COA-SYNTHETASES, AND USES THEREOF - The present invention provides isolated polynucleotides and isolated polypeptides. The polypeptides of the present invention have isoprenoid wax ester synthase activity or isoprenoid acyl CoA-synthetase activity. The present invention also includes methods of using the polynucleotides and polypeptides of the present invention. For instance, the methods include producing biodiesel and producing wax esters. | 2009-05-07 |
20090117630 | FERMENTATION PRODUCT PROCESSES - The present invention relates to processes for production of an ethanol product from granular starch | 2009-05-07 |
20090117631 | ALCOHOL EXTRACTION PROCESS FOR BIOFUEL PRODUCTION - This document describes a fermentation product producing or processing apparatus or process involving membrane pervaporation (PV) and either vapor permeation or distillation or both. The fermentation product may be produced semi-continuously wherein product concentration is maintained below a selected value by removal through pervaporation membranes. After a period of operation, the broth may be distilled. Distillation and/or pervaporation products may be further dewatered using vapor permeation. The PV membranes may be used in the form of immersed modules, for example with a flat sheet configuration. | 2009-05-07 |
20090117632 | USE OF ETHANOL PLANT BY-PRODUCTS FOR YEAST PROPAGATION - Embodiments of the invention relate, for example, to methods for reducing the load of organic acids and glycerol in water recycled to the fermentation process. Organic acids and glycerol produced during ethanol fermentation are used as a replacement for carbohydrates for propagation of yeast. The yeast may be sold as a feed product or used in subsequent fermentation. | 2009-05-07 |
20090117633 | Process of Producing Ethanol Using Starch with Enzymes Generated Through Solid State Culture - The present invention is directed to process of producing ethanol using starch with enzymes generated through solid state culture. | 2009-05-07 |
20090117634 | Process of Producing Ethanol Using Cellulose with Enzymes Generated Through Solid State Culture - The present invention is directed to process of producing ethanol using cellulose with enzymes generated through solid state culture. | 2009-05-07 |
20090117635 | Process for Integrating Cellulose and Starch Feedstocks in Ethanol Production - The present invention is directed to process integrating cellulose and starch feedstocks to produce ethanol. | 2009-05-07 |
20090117636 | METHOD AND APPARATUS FOR ACCELERATING GROWTH OF E. COLI BY APPLYING ELECTRIC FIELD - Disclosed are a method and an apparatus for accelerating the growth of | 2009-05-07 |
20090117637 | SUBSTRATES CONTAINING POLYPHOSPHAZENE AS MATRICES AND SUBSTRATES CONTAINING POLYPHOSPHAZENE WITH A MICRO-STRUCTURED SURFACE - This disclosure relates to substrates containing at least one polyphosphazene with a forming surface as matrices for producing biological materials that can be implanted in a mammal. The disclosure also relates to a method for producing such substrates and substrates containing polyphosphazene with a micro-structured surface. | 2009-05-07 |
20090117638 | BILIRUBIN OXIDASE MUTANT HAVING THERMAL STABILITY - A heat-resistant bilirubin oxidase mutant is disclosed. The bilirubin oxidase is obtained by deletion, replacement, addition or insertion of at least one amino acid residue of a wild type amino sequence of SEQ. ID. No. 1 of a bilirubin oxidase derived from an imperfect filamentous fungus, | 2009-05-07 |
20090117639 | Neural Progenitor Cell Populations - This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates differentiation, and establishes the neural progenitor population. The progenitors can be further differentiated in culture into a variety of different neural phenotypes, including dopaminergic neurons. The differentiated cell populations or the neural progenitors can be generated in large quantities for use in drug screening and the treatment of neurological disorders. | 2009-05-07 |
20090117640 | Transglutaminase Variants with Improved Specificity - Variants of transglutaminase from | 2009-05-07 |
20090117641 | Mutated Abl Kinase Domains - The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides. | 2009-05-07 |
20090117642 | ALPHA-AMYLASE VARIANTS WITH ALTERED PROPERTIES - Disclosed are compositions comprising variants of a parent | 2009-05-07 |
20090117643 | Tumor-targeting gene-virus zd55-il 24,its construction method and application thereof - This present invention disclosed a tumor-targeting gene-virus ZD55-IL-24, which is a recombinant Ad5 with a deletion of E1B 55K da gene and carries the anti-tumor gene IL-24. This present invention also disclosed its construction method and its application in cancer gene-therapy. The tumor-targeting gene-virus ZD55-IL-24 of this invention can be used in the therapy of many kinds of tumors, so it can be used in developing the new effective tumor therapy medicine. | 2009-05-07 |
20090117644 | RECOMBINANT HSV USEFUL FOR TREATMENT OF HUMAN GLIOMA - The present invention provides a recombinant HSV having the ability to specifically kill tumor cells such as human glioma cells in vivo, useful and safe for treating human glioma, etc. and that can easily put to clinical use. A new recombinant HSV, KeM345, is constructed by inserting a γ34.5 gene transcription unit, which is expressed by Musashil promoter, into a ribonucleotide reductase gene site of the genome of a herpes simplex virus (HSV) previously attenuated, by means of homologous recombination and obtained as a purified strain. Since KeM345 is a recombinant virus itself, it can not only induce viral proliferation by being transmitted to culture cells but can also induce viral replication equivalent to that of wild-type HSV, showing an excellent cytotoxic effect (cytolytic ability) selectively upon a malignant glioma. | 2009-05-07 |
20090117645 | Biochips and methods of fabricating the same - Biochips for analyzing components of a biological sample using probes and methods of fabricating the same are provided. In some embodiments, a biochip includes a substrate, a plurality of probes immobilized on a top surface of the substrate, and a capping layer formed on a bottom surface of the substrate. | 2009-05-07 |
20090117646 | DEVICE, KIT AND METHOD FOR PULSING BIOLOGICAL SAMPLES WITH AN AGENT AND STABILISING THE SAMPLE SO PULSED - A device and kit for pulsing a biological sample with a pulsing agent is disclosed. The biological sample so pulsed is subsequently stabilized and the device or kit provides a control reaction. Applications for the described device and kit are found in the field of medical diagnostics, particularly immunology. | 2009-05-07 |
20090117647 | METHOD FOR ON-LINE OPTIMIZATION OF A FED-BATCH FERMENTATION UNIT TO MAXIMIZE THE PRODUCT YIELD - A method for on-line optimization of fed-batch fermentation unit containing bacteria and nutrients is disclosed. Parameters of the fermenter model used in optimization calculations are estimated periodically to reduce the mismatch between the plant and the calculated values. The updated fermenter model is used to calculate the optimum sugar feed rate to maximize the product yield. The method/fermenter model is implemented as a software program in a PC that can be interfaced to plant control systems for on-line deployment in an actual plant environment. An on-line optimization system is useful to the plant operating personnel, to maximize the product yield from the fed-batch fermenter unit. In another aspect, a plant control system to control a fed-batch fermentation based on the described method is also disclosed. | 2009-05-07 |
20090117648 | VESSEL AND METHOD OF MANUFACTURE THEREOF - The invention concerns a novel sample tube and a method of manufacturing a such a sample tube. According to the method an oversized mould cavity is formed with an opposing pair of mould members of an injection moulding machine, the mould members being movable relative to each other and between which mould members the sample tube is formed. A volume of resin exceeding the prescribed volume of the sample tube is injected into the cavity and force is applied to said mould members in order to reduce the volume of said mould cavity for displacing molten polymer in the cavity and for compressing the polymer to form said sample tube. By means of the invention, sample tubes and vessels having ultra thin walls can be manufactured. | 2009-05-07 |
20090117649 | ISOLATED SOLUBLE CORTICOTROPIN RELEASING FACTOR RECEPTOR TYPE 2 (SCRFR2) - The present invention is directed to compositions and methods related to soluble G-protein coupled receptors (sGPCR). In certain aspects the invention includes compositions and methods related to a soluble corticotropin releasing factor receptor related protein, sCRFR2, as well as its effects on CRFR signaling and interaction between CRF family ligand and CRFR receptors, including but not limited to CRFR2, CRFR1 and functional or signaling capable variants thereof. | 2009-05-07 |
20090117650 | MODIFIED GREEN FLUORESCENT PROTEINS AND METHODS FOR USING SAME - The present invention provides nucleic acid molecules encoding mutant fluorescent proteins as well as proteins encoded by these nucleic acids. In addition, host-cells, stable cell lines and transgenic organisms comprising the above-referenced nucleic acid molecules are provided. The subject protein and nucleic acid compositions find use in a variety of different applications and methods, particularly for labeling of biomolecules, cells, or cell organelles. | 2009-05-07 |
20090117651 | Nucleoside compounds and methods of use thereof - The present invention provides methods of utilizing a nucleoside derivative having the chemical formula of Formula (I) to downregulate expression of an anti-apoptotic protein such as survivin in a cell, induce apoptosis in a cell, inhibit angiogenesis in a cell, inhibit binding of p53 to DNA in a cell, inhibit phosphorylation of Akt in a cell and inhibit HIV transcription in a cell, by administering to the cell or tissue an amount of a compound of Formula (I) sufficient to achieve the desired activity. Formula (I): wherein the substituents R | 2009-05-07 |
20090117652 | USE OF CXCL6 CHEMOKINE IN THE PREVENTION OR REPAIR OF CARTILAGE DEFECTS - The present invention disclosed the expression of CXCL6 by cells which are able to form stable cartilage. The invention describes the use of these cells and of CXCL6 to promote cartilage (and underlying bone) formation e.g. in the repair of cartilage or osteochondral defects. The invention further describes the use of chemokines in the modulation of progenitor cell differentiation. | 2009-05-07 |
20090117653 | METHOD AND APPARATUS FOR EVALUATING THERAPEUTICS ON CANCER STEM CELLS - Embodiments provide cell culture methods to produce a 3-D model assembly that mimics in vitro the microenvironment of human bone marrow, where cells occupy distinct niches. Methods and apparatuses are provided for the efficient testing of cancer, including malignant hematopoietic cancers and metastatic spread to the bone marrow of solid tumors, and of other diseases of the blood and bone marrow. Methods and apparatuses are further provided in embodiments for the investigation of bone marrow cell biological characteristics and for the testing of therapeutics for nonmalignant diseases of the blood and bone marrow. | 2009-05-07 |
20090117654 | MEDIUM FOR CULTURING HEMATOPOIETIC CELLS AND A METHOD OF CULTURING HEMATOPOIETIC CELLS - Provided are a medium for culturing hematopoietic cells including lysyl oxidase inhibitor and a method of culturing hematopoietic cells using the medium. | 2009-05-07 |
20090117655 | Culture Matrix for Forming a Cell Spheroid, and Method of Culturing the Same - A culture method for allowing only cancer cells to grow from a cancerous organ or tissue sample removed surgically or endoscopically, forming a spheroid of cancer cells having a tissue structure and different cell stages similar to a tissue structure and cell stages in the living body, and removing the cultured spheroid of cancer cells from the matrix by changing the temperature within the physiological temperature range. | 2009-05-07 |
20090117656 | STIMULI-RESPONSIVE DEGRADABLE GEL - To provide a new reductive-stimuli-responsive degradable gel that allows any control of decomposition of the three-dimensional base material for cell culture and production of a completely biological three-dimensional cellular structure consisting only of cells and cells-produced extracellular matrix and that allows safe recovery of the cellular structure produced. | 2009-05-07 |
20090117657 | Preparation For Transferring Nucleic Acid Into Cell - The present invention provides a composition comprising a polysaccharide to enhance transfection of a cell with a nucleic acid. The present invention also provides a method for transfecting a cell with a nucleic acid comprising the steps of forming a polyionic complex of the nucleic acid and a polysaccharide; and bringing about uptake of the polyionic complex by the cell. Preferably, the cell is selected from bone marrow mesenchymal stem cells, nervous system cell lines, adipose tissue stem cells, immunocytes, neurons, and chondrocytes. Moreover, preferably the polysaccharide is a cationized pullulan derivative, a cationized dextran derivative, or a cationized mannan derivative. | 2009-05-07 |
20090117658 | Macrophage transfection method - Described are a method and a composition for transfecting monocytes, as well as use of the same for therapeutic purposes. The composition is composed of a nucleic acid component, a lysosome evading component and a digestible particle that can be phagocytized. Preferably, the monocyte is a macrophage and the digestible particle is from a natural source, such as from a microbial source. More preferably, the digestible particle is a yeast cell wall particle such as zymosan. The composition itself, or cells pretreated with the composition, are useful in all gene medicine applications, such as gene therapy, gene vaccination, cancer treatment as well as immunomodulation and tissue repair. | 2009-05-07 |
20090117659 | Process for Evaluating Quality of Coke and Bitumen of Refinery Feedstocks - This invention relates to processes for the evaluation of the coke and/or bitumen quality of a plurality of refinery feedstocks using high throughput experimentation. | 2009-05-07 |
20090117660 | Devices and methods for sample collection and analysis - The present invention provides devices, methods, and kits for the collection of a solid or semi-solid sample and analysis for the presence, absence, or quantity of an analyte. The invention provides a collection slide having a first card and a second card. The first card has a sample collection area. The first and second cards have orifices allowing the passage of fluid through the sample collection area, and the cards are hingeably connected to each other. The invention also provides an assay device having a housing with a test element, a results window, and a docking area for receiving and engaging the collection slide. In one embodiment the collection slide and device can be used to detect the presence of fecal occult blood (human hemoglobin) in a stool sample. Many other embodiments are described herein. | 2009-05-07 |
20090117661 | METHOD OF ELIMINATING REACTIVITY OF LIPOARABINOMANNAN AND APPLICATION OF THE SAME - A method of eliminating the reactivity of lipoarabinomannan contained in a sample to a | 2009-05-07 |
20090117662 | Mutants of IGF Binding Proteins and Methods of Production of Antagonists Thereof - The present invention provides a crystal suitable for X-ray diffraction, comprising a complex of insulin-like growth factor I or II (IGF) and a polypeptide consisting of the amino acids 40-92 of IGFBP-5 or a fragment thereof consisting at least of the 9 | 2009-05-07 |
20090117663 | SAMPLING DEVICE - A sampling device for analysis of a substance which is chosen from the group consisting of isocyanates, aminoisocyanates, amines, and isothiocyanates, and which is present in an air flow intended to pass through the sampling device is disclosed, as well as a method for the production of said sampling device, and a method for the analysis of said substance in the air flow. | 2009-05-07 |
20090117664 | LIQUID SENDING METHOD OF LIQUID IN SUBSTRATE CHANNEL AND LIQUID SENDING APPARATUS - A liquid sending method includes the step of introducing either one fluid of a gas or an insulating liquid into a channel disposed on a substrate, thereby dividing a liquid flowing in the channel and sending the liquid. | 2009-05-07 |
20090117665 | Rapid sample collection and analysis device and methods of use - The present invention is directed to devices and methods for determining the presence of analyte in a fluid sample. The devices utilize a sample collection well, an expression plate for expressing sample into the sample collection well, a plunger that drives a lance, and a test compartment containing test elements. The devices also preserve an aliquot of fluid sample in a reservoir for later confirmation testing. When the plunger is lowered into the sample collection well, a lance on the device punctures a frangible material that covers a sample outlet. When the sample outlet is thus opened, fluid sample flows from the sample collection cup to the test compartment. In one embodiment the plunger is lowered as a cap is applied to the device. The devices are useful for detecting the presence of analyte in a wide variety of fluid samples, such as saliva, oral fluids, and more. The invention also provides methods of using the devices, and kits containing the devices. | 2009-05-07 |
20090117666 | System and Method for Quantifying Analytes in Immuno or Enzymatic Assays - The present invention provides apparatus and methods for performing assays for determining the presence of and/or quantifying an analyte in a sample. The analyte and a label preferably immobilized on a particle are mixed to provide a homogenous solution. The homogeneous solution can be optionally made to flow through a filter. The homogenous solution or the filtrate can be metered through the read zone at a controlled flow rate and the presence of the label or the presence of the particle can be detected. The methods and apparatus of the invention do not require the use of a capture zone. | 2009-05-07 |
20090117667 | METHODS FOR MEASURING AFFINITY SUBSTANCES IN SAMPLES COMPRISING STEP OF DISRUPTING BLOOD CELL COMPONENTS - The present invention provides methods for measuring an affinity substance using pearl chain formation of carrier particles, in which the methods include the step of electrically disrupting blood cell components. Blood cell components which interfere with the counting of carrier particles are electrically disrupted. Furthermore, blood cell components can be disrupted without addition of hemolytic agents which interfere with immunological reactions. Whole blood samples can be directly used as measurement samples without separating serum or plasma. Therefore, it is unnecessary to separate serum or plasma when analyzing blood components. | 2009-05-07 |
20090117668 | Immune Agglutination Reagent Kit and Method of Measuring Antigen - In cases of poor reaction efficiency with the antibody due to inadequate number of epitopes or steric hindrance caused by epitopes being close to each other, this invention provides a direct method of efficiently measuring antigen in a given specimen without the need of pretreating it. Two types of monoclonal antibodies that recognize different epitopes are individually sensitized on separate latex. The specimen and one latex sensitized monoclonal antibody reagent are reacted to produce a reaction solution which is then reacted with the other latex sensitized monoclonal antibody reagent. The antigen can thus be directly measured in an efficient and highly sensitive way without pretreating it. | 2009-05-07 |
20090117669 | SUBSTRATE FOR TARGET SUBSTANCE DETECTING DEVICE, TARGET SUBSTANCE DETECTING DEVICE, TARGET SUBSTANCE DETECTING APPARATUS AND METHOD USING THE SAME, AND KIT THEREFOR - A substrate for forming a target substance detecting device includes a supporting member, an underlying layer disposed on a surface of the supporting member, and a metal pattern layer, disposed on a surface of the underlying layer, for being bound to a target substance trapping substance capable of trapping a target substance in a specimen solution at least containing water as a liquid medium to detect the target substance by utilizing plasmon resonance. The underlying layer has a refractive index nb satisfying the following relationship: | 2009-05-07 |
20090117670 | DETECTION OF TARGET MOLECULES IN A SAMPLE BY USING A MAGNETIC FIELD - The application relates to a method for detecting a target in a sample suspected of containing the target. The method comprises contacting the sample and a first binding molecule attached to a magnetic particle with a second binding molecule attached to a solid support. The first binding molecule is capable of binding to the second binding molecule, and the target is capable of interfering with this binding. Magnetic force is applied to bring the magnetic particle into close proximity with the solid support. The number of magnetic particles bound to the solid support is detected. | 2009-05-07 |
20090117671 | METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE INCLUDING FERREOELECTRIC CAPACITOR - A method for manufacturing a semiconductor device includes the step of conducting an acceptance/rejection judgment about the semiconductor device. The acceptance/rejection judgment is conducted by using a hysteresis loop that indicates the relationship between the applied voltage and the polarization quantity of the ferroelectric capacitor. | 2009-05-07 |
20090117672 | Light emitting devices with phosphor wavelength conversion and methods of fabrication thereof - A method of fabricating a light emitting device having a specific target color, CIE xy, of emitted light is described. The device comprises a light emitting diode that is operable to emit light of a first wavelength range and at least one phosphor material which converts at least a part of the light into light of a second wavelength range wherein light emitted by the device comprises the combined light of the first and second wavelength ranges. The method comprises: depositing a pre-selected quantity of the at least one phosphor material on a light emitting surface of the light emitting diode; operating the light emitting diode; measuring the color of light emitted by the device; comparing the measured color with the specific target color; and depositing and/or removing phosphor material to attain the desired target color. | 2009-05-07 |
20090117673 | FAILURE DETECTING METHOD, FAILURE DETECTING APPARATUS, AND SEMICONDUCTOR DEVICE MANUFACTURING METHOD - A failure detecting method has inputting a foreign substance inspection map created by foreign substance inspection for a wafer surface after each processing process in a wafer processing process, inputting a die sort map created by a die sort test after the wafer processing process, setting a plurality of region segments in the wafer, setting a region number for each of the region segments, calculating foreign substance density in each of the region segments, based on the foreign substance inspection map, and plotting the foreign substance density, using the region numbers, to calculate a foreign substance inspection map waveform characteristic amount, calculating failure density in each of the region segments, based on the die sort map, and plotting the failure density, using the region numbers, to calculate a die sort map waveform characteristic amount, calculating similarity between the foreign substance inspection map waveform characteristic amount and the die sort map waveform characteristic amount, and identifying a processing process that is a cause of failure occurrence, based on the similarity. | 2009-05-07 |
20090117674 | Method for manufacturing field emission electron source having carbon nanotubes - A method for manufacturing a field emission electron source includes: providing a CNT array; drawing a bundle of CNTs from the CNT array to form a CNT yarn; soaking the CNT yarn into an organic solvent, and shrinking the CNT yarn into a CNT string after the organic solvent volatilizing; applying a voltage between two opposite ends of the CNT string, until the CNT string snapping at a certain point; and attaching the snapped CNT string to a conductive base, and achieving a field emission electron source. The field emission efficiency of the field emission electron source is high. | 2009-05-07 |
20090117675 | Method for Producing Group 3-5 Nitride Semiconductor and Method for Producing Light-Emitting Device - The present invention provides a method for producing a group 3-5 nitride semiconductor and a method for producing a light emitting device. The method for producing a group 3-5 nitride semiconductor, comprises the steps of (i), (ii), (iii) and (iv) in this order: (i) placing inorganic particles on a substrate, (ii) growing a semiconductor layer, and (iii) separating the substrate and the semiconductor layer by irradiating the interface between the substrate and the semiconductor layer with light. | 2009-05-07 |
20090117676 | Semiconductor optical device - A method of fabricating a semiconductor optical device is disclosed. This semiconductor optical device includes first and second optical semiconductor elements. This method comprises the steps of: growing, in a metal-organic vapor phase deposition reactor, plural semiconductor layers for the first semiconductor optical element on a primary surface of a substrate which has first and second areas for the first semiconductor optical element and the second optical semiconductor element, respectively; forming an insulating mask on the plural semiconductor layers and the first area; etching the plural semiconductor layers by use of the insulating mask to form a semiconductor portion having an end face; growing a layer of a first semiconductor on the second area and deposit of the first semiconductor on the end face in the reactor by use of the insulating mask; supplying etchant for etching the first semiconductor to remove at least a part of the deposit of the first semiconductor on the end face by use of the insulating mask; and after removing the deposit of the first semiconductor, growing a layer of a second semiconductor for the second optical element on the second area in the reactor by use of the insulating mask. | 2009-05-07 |
20090117677 | Rubbing system for alignment layer of LCD and method thereof - A rubbing system for an alignment layer of a liquid crystal display (LCD) device, comprises: a rubbing table on which a substrate having an alignment layer thereon is positioned; a rubbing roll on which a rubbing material is wound, substantially positioned on the rubbing table thus to substantially contact the alignment layer, for rubbing the alignment layer by rotation of the rubbing roll; and a controlling unit for controlling the alignment layer to be rubbed by substantially contacting the rubbing roll onto the alignment layer by simultaneously lifting and lowering a rubbing table and the rubbing roll according to an alignment controlling force to be applied to the alignment layer. | 2009-05-07 |
20090117678 | Semiconductor laser with a weakly coupled grating - A semiconductor laser with a semiconductor substrate, a laser layer arranged on the semiconductor substrate, a waveguide arranged parallel to the laser layer and a strip shaped grating structure is disclosed. The laser layer, the waveguide and the grating are arranged in a configuration which results in weak coupling between the laser light and the grating structure, so that the laser light interacts with an increased number of grating elements. A process for the production of such a semiconductor laser is also disclosed. | 2009-05-07 |
20090117679 | METHODS FOR FORMING CRYSTALLINE THIN-FILM PHOTOVOLTAIC STRUCTURES - Methods for forming semiconductor devices include providing a textured template, forming a buffer layer over the textured template, forming a substrate layer over the buffer layer, removing the textured template, thereby exposing a surface of the buffer layer, and forming a semiconductor layer over the exposed surface of the buffer layer. | 2009-05-07 |
20090117680 | METHOD FOR MANUFACTURING PHOTOELECTRIC CONVERSION DEVICE - A photoelectric conversion device which is excellent in photoelectric conversion characteristics is provided by effectively utilizing silicon semiconductor materials. The present invention relates to a method for manufacturing a photoelectric conversion device using a solar cell, in which a plurality of single crystal semiconductor substrates in each of which a damaged layer is formed at a predetermined depth is arranged over a supporting substrate having an insulating surface; a surface layer part of the single crystal semiconductor substrate is separated thinly using the damaged layer as a boundary so as to form a single crystal semiconductor layer over one surface of the supporting substrate; and the single crystal semiconductor layer is irradiated with a laser beam from a surface side which is exposed by separation of the single crystal semiconductor layer to planarize the surface of the single crystal semiconductor layer. | 2009-05-07 |
20090117681 | SEMICONDUCTOR DEVICE AND MANUFACTURING METHOD THEREOF - The object of the present invention is to miniaturize the area occupied by the element and to integrate a plenty of elements in a limited area so that the sensor element can have higher output and smaller size. | 2009-05-07 |
20090117682 | Method for Manufacturing Image Sensor - A method for manufacturing an image sensor is provided. The method can include forming an oxide layer on a color filter layer, forming a first oxide layer microlens by etching the oxide layer, forming a second oxide layer microlens on the first oxide layer microlens, and forming a third oxide layer microlens on the second oxide layer microlens. | 2009-05-07 |
20090117683 | Method of manufacturing single crystal substate and method of manufacturing solar cell using the same - In accordance with the present invention, a method for manufacturing a single-crystal substrate comprising the steps of: preparing a square-shaped frame; pouring polycrystalline molten silicon into the prepared frame; cooling and crystallizing the molten silicon; and forming the single-crystal silicon substrate by transferring a heating element from one corner of the frame to another corner opposite the corner, thus simplifying the entire manufacturing process of the single-crystal substrate and reducing the material cost. | 2009-05-07 |
20090117684 | METHOD AND APPARATUS FOR FORMING COPPER INDIUM GALLIUM CHALCOGENIDE LAYERS - A multilayer structure to form absorber layers for solar cells. The multilayer structure includes a base comprising a contact layer on a substrate layer, a first layer on the contact layer, and a metallic layer on the first layer. The first layer includes an indium-gallium-selenide film and the gallium to indium molar ratio of the indium-gallium-selenide film is in the range of 0 to 0.8. The metallic layer includes gallium and indium without selenium. Additional selenium is deposited onto the metallic layer before annealing the structure for forming an absorber. | 2009-05-07 |
20090117685 | THIN FILM SOLAR CELL AND ITS FABRICATION - A method for producing a solar cell including the steps of forming a p-type microcrystalline silicon oxide layer on a glass substrate using a PECVD method and raw gases comprising Silane gas, Diborane gas, Hydrogen gas and Carbon Dioxide gas. The method may employ a frequency of between about 13.56-60 MHz. The PECVD method may be performed at a power density of between about 10-40 mW/cm | 2009-05-07 |
20090117686 | METHOD OF FABRICATING ORGANIC SEMICONDUCTOR DEVICE - A method of fabricating an organic semiconductor device includes following steps. A gate conductive layer is formed on a substrate, and then a gate dielectric layer is formed. Next, patterned metal layers are formed on the gate dielectric layer beside the gate conductive layer. An electrode modified layer is then formed on the surface and the sidewall of each patterned metal layer, and the patterned metal layers and the electrode modified layers formed thereon serve as a source and a drain. Thereafter, an organic semiconductor layer is formed on the source and the drain and on a portion of the gate dielectric layer exposed between the source and the drain to be an active layer. | 2009-05-07 |
20090117687 | Semiconductor device and method of manufacturing the same, circuit board, and electronic instrument - A method of manufacturing a semiconductor device forms a penetrating hole in a substrate so that the penetrating hole extends from a first surface of the substrate to a second surface of the substrate being opposite to the first surface. An internal wall surface of the penetrating hole has a protrusion formed of a material constituting the substrate, the first surface of the substrate being closer to the protrusion than the second surface. A conductive member is formed on the first surface so that the conductive member covers the penetrating hole. A semiconductor chip is mounted on the first surface so that an electrode of the semiconductor chip is electrically connected to the conductive member. An external electrode is provided through the penetrating hole so that the external electrode is electrically connected to the conductive member and the external electrode projects from the second surface of the substrate. | 2009-05-07 |
20090117688 | FLIP CHIP MOUNTING METHOD AND BUMP FORMING METHOD - A flip chip mounting method which is applicable to the flip chip mounting of a next-generation LSI and high in productivity and reliability as well as a bump forming method are provided. After a resin | 2009-05-07 |
20090117689 | PACKAGED INTEGRATED CIRCUITS - A packaged, optically active integrated circuit device is shown is manufactured by mounting the integrated circuit ( | 2009-05-07 |
20090117690 | INTEGRATED TRANSISTOR MODULE AND METHOD OF FABRICATING SAME - An integrated transistor module includes a lead frame that defines at least one low-side land and at least one high-side land. A stepped portion of the lead frame mechanically and electrically interconnects the low-side and high-side lands. A low-side transistor is mounted upon the low-side land with its drain electrically connected to the low-side land. A high-side transistor is mounted upon the high-side land with its source electrically connected to the high-side land. | 2009-05-07 |
20090117691 | METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - To achieve electro-optical devices typified by active matrix liquid crystal display devices with higher productivity and yield and lower manufacturing cost by reducing the number of steps of manufacturing a terminal portion and a pixel portion having an inverted staggered thin film transistor, specifically by reducing the number of photomasks used in a photolithography process. In view of this object, a photomask (multitone photomask) formed in such a manner that a light-transmitting substrate is provided with a transmitting portion, a partially-transmitting portion having a function of reducing light intensity, and a light-blocking portion is employed. Moreover, a lift-off method which does not require an etching step in patterning of a source electrode and a drain electrode of the pixel portion and a source wiring that extends to the terminal portion is employed. | 2009-05-07 |
20090117692 | MANUFACTURING METHOD OF SEMICONDUCTOR DEVICE - A single crystal semiconductor substrate bonded over a supporting substrate with a buffer layer interposed therebetween and having a separation layer is heated to separate the single crystal semiconductor substrate using the separation layer or a region near the separation layer as a separation plane, thereby forming a single crystal semiconductor layer over the supporting substrate. The single crystal semiconductor layer is irradiated with a laser beam to re-single-crystallize the single crystal semiconductor layer through melting. An impurity element is selectively added into the single crystal semiconductor layer to form a pair of impurity regions and a channel formation region between the pair of impurity regions. The single crystal semiconductor layer is heated at temperature which is equal to or higher than 400° C. and equal to or lower than a strain point of the supporting substrate and which does not cause melting of the single crystal semiconductor layer. | 2009-05-07 |