| 19th week of 2009 patent applcation highlights part 40 |
| Patent application number | Title | Published |
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| 20090117489 | Compositons and processes for immersion lithography - New photoresist compositions are provided that are useful for immersion lithography. Preferred photoresist compositions of the invention comprises two or more distinct materials that can be substantially non-mixable with a resin component of the resist. Particularly preferred photoresists of the invention can exhibit reduced leaching of resist materials into an immersion fluid contacting the resist layer during immersion lithography processing. | 2009-05-07 |
| 20090117490 | POSITIVE RESIST COMPOSITION FOR IMMERSION LITHOGRAPHY AND METHOD FOR FORMING RESIST PATTERN - A positive resist composition for immersion lithography of the present invention includes a resin component (A) which exhibits increased alkali solubility under the action of acid; and an acid generator component (B) which generates acid on exposure, wherein the resin component (A) includes a cyclic main chain resin (A1) containing a fluorine atom and no acid-dissociable group, and a resin (A2) containing a structural unit (a) derived from an acrylic acid and no fluorine atom. | 2009-05-07 |
| 20090117491 | RESOLUTION ENHANCEMENT TECHNIQUES COMBINING INTERFERENCE-ASSISTED LITHOGRAPHY WITH OTHER PHOTOLITHOGRAPHY TECHNIQUES - Methods and systems are disclosed that provide multiple lithography exposures on a wafer, for example, using interference lithography and optical photolithography. Various embodiments may balance the dosage and exposure rates between the multiple lithography exposures to provide the needed exposure on the wafer. Other embodiments provide for assist features and/or may apply resolution enhancement to various exposures. In a specific embodiment, a wafer is first exposed using optical photolithography and then exposed using interference lithography. | 2009-05-07 |
| 20090117492 | METHOD FOR FORMING FINE PATTERN IN SEMICONDUCTOR DEVICE - A method is used in forming a fine pattern in a semiconductor device. The method includes forming an etch target layer; forming a photoresist pattern over the etch target layer; forming a polymer pattern including silicon-oxygen (Si—O) bonds on sidewalls of the photoresist pattern; removing the photoresist pattern; and etching the etch target layer using the polymer pattern as an etch mask. | 2009-05-07 |
| 20090117493 | Anti-Reflective Coating Forming Composition Containing Reaction Product of Isocyanuric Acid Compound with Benzoic Acid Compound - There is provided anti-reflective coating forming composition containing a reaction product of an isocyanuric acid compound having two or three 2,3-epoxypropyl groups with a benzoic acid compound. The anti-reflective coating obtained from the composition has a high preventive effect for reflected light, causes no intermixing with photoresists, can form a photoresist pattern having no footing at the lower part, and can use in lithography process by use of a light such as ArF excimer laser beam and F2 excimer laser beam, etc. | 2009-05-07 |
| 20090117494 | CONTROLLER FOR OPTICAL DEVICE, EXPOSURE METHOD AND APPARATUS, AND METHOD FOR MANUFACTURING DEVICE - An exposure method for exposing a mask pattern, which includes plural types of patterns, with a high throughput and optimal illumination conditions for each type of pattern. The method includes guiding light from a first spatial light modulator illuminated with pulse lights of illumination light to a second spatial light modulator and exposing a wafer with light from the second spatial light modulator, accompanied by: controlling a conversion state of the second spatial light modulator including a plurality of second mirror elements; and controlling a conversion state of the first spatial light modulator including a plurality of first mirror elements to control intensity distribution of the illumination light on a predetermined plane between the first spatial light modulator and the second spatial light modulator. | 2009-05-07 |
| 20090117495 | METHOD FOR FORMING A PATTERN IN A SEMICONDUCTOR DEVICE AND METHOD FOR MANUFACTURING A FLASH MEMORY DEVICE - A pattern formation method of a semiconductor device, and to a manufacturing method of a flash memory, in which spacer patterning technology is performed while two hard mask layers having a different etching characteristics are used, such that the patterning can be performed by using only a spacer as a mask in the region which requires a small pattern. Additionally, the patterning can be performed by using a hard mask layer pattern and the spacer as a mask in a region which requires a large pattern. Therefore, the pattern formation method of the invention can be used to form a semiconductor device with patterns having various sizes using just a single patterning. | 2009-05-07 |
| 20090117496 | METHOD FOR TREATING SURFACE OF ELEMENT - A method for treating a surface of an element includes the steps of providing a photo-sensitive and flexible thin film, providing a planar photomask having a micro-structural pattern, transferring the micro-structural pattern to the thin film, attaching the thin film to the surface of the element and partially exposing a portion of the element, processing the exposed portion of the element, and removing the thin film to form a micro-structure on the surface of the element. | 2009-05-07 |
| 20090117497 | METHOD OF FORMING PATTERN USING FINE PITCH HARD MASK - A method of forming a fine pattern of a semiconductor device using a fine pitch hard mask is provided. A first hard mask pattern including first line patterns formed on an etch target layer of a substrate with a first pitch is formed. A first layer including a top surface where a recess is formed between adjacent first line patterns is formed. A second hard mask pattern including second line patterns within the recess is formed. An anisotropic etching process is performed on the first layer using the first and the second line patterns as an etch mask. Another anisotropic etching process is performed on the etch target layer using the first and the second hard mask patterns as an etch mask. | 2009-05-07 |
| 20090117498 | PATTERN FORMING METHOD - A pattern forming method according to an embodiment of the present invention includes forming a resist layer on a semiconductor substrate, selectively exposing the resist layer, developing the selectively exposed resist layer, decomposing photosensitizer in the resist layer after developing the resist layer, removing the photosensitizer or acid generated from the decomposed photosensitizer, applying a shrink material on the developed resist layer after removing the photosensitizer or the acid generated from the decomposed photosensitizer, performing a heating process for the resist layer on which the shrink material is applied, and removing a part of the heat-processed shrink material. | 2009-05-07 |
| 20090117499 | Cleaning solution for immersion photolithography system and immersion photolithograph process using the cleaning solution - A cleaning solution for an immersion photolithography system according to example embodiments may include an ether-based solvent, an alcohol-based solvent, and a semi-aqueous-based solvent. In the immersion photolithography system, a plurality of wafers coated with photoresist films may be exposed pursuant to an immersion photolithography process using an immersion fluid. The area contacted by the immersion fluid during the exposure process may accumulate contaminants. Accordingly, the area contacted by the immersion fluid during the exposure process may be washed with the cleaning solution according to example embodiments so as to reduce or prevent defects in the immersion photolithography system. | 2009-05-07 |
| 20090117500 | PHOTORESIST STRIP WITH OZONATED ACETIC ACID SOLUTION - A solution, apparatus, and method for stripping photoresist from a workpiece are disclosed. Embodiments of the invention describe a solution comprising diluted liquid acetic acid and dissolved gaseous ozone. In an embodiment an ozonated liquid acetic acid solution is prepared by dissolving ozone in liquid DI water and then mixing with liquid acetic acid. In another embodiment an ozonated liquid acetic acid solution is prepared by mixing liquid DI water and liquid acetic acid and then dissolving ozone. The ozonated liquid acetic acid solution is used to strip a layer of photoresist from a workpiece with improved performance. | 2009-05-07 |
| 20090117501 | METHODS OF FABRICATING AND IGNITING FLARES INCLUDING REACTIVE FOIL AND A COMBUSTIBLE GRAIN - Flares include grain assemblies comprising a combustible grain and a reactive foil positioned at least proximate to the grain and configured to ignite combustion of the grain upon ignition of the reactive foil. The reactive foil may include alternating layers of reactive materials. Methods of fabricating flares include at least partially covering an exterior surface of a combustible grain with a reactive foil to form a grain assembly, and inserting the grain assembly at least partially into a casing. The reactive foil may include alternating layers of reactive materials that are configured to react with one another in an exothermic chemical reaction upon ignition. Furthermore, methods of igniting a flare grain include initiating an exothermic chemical reaction between alternating layers of reactive materials in a reactive foil located proximate to the flare grain. | 2009-05-07 |
| 20090117502 | Combustor and Method of Operating a Combustor - A combustor comprises in flow series a burner, a transition piece and a combustion chamber being of larger diameter than the transition piece, the combustion chamber being connected to the transition piece via a dome portion. In the dome portion are located air injection openings. A method of operating the combustor comprises the stop of introducing air from the dome portion by means of air jets. | 2009-05-07 |
| 20090117503 | Burner Control - A reactant supply and control system supplies a regenerative burner assembly with streams of pilot fuel and pilot air. The system can maintain a pilot flame throughout regenerative cycles in which a main flame is turned on and off, and supplies either or both of the pilot streams with an increased flow rate for shifting from a regenerative exhaust condition to a regenerative firing condition. | 2009-05-07 |
| 20090117504 | Furnace assembly - The invention relates to a furnace assembly for dental technology, in particular for ceramic dental compositions, comprising a display device associated with a furnace assembly ( | 2009-05-07 |
| 20090117505 | Portable Heat Transfer Apparatus - The present invention relates to a portable heat transfer apparatus designed to supply heat to an external heat load, such as a space-heating unit or a heating garment, in a manner to be usable in outdoor and other environments where it is difficult to receive a supply of electricity or fuel gas, and allows a ratio of LPG and air to be controlled so as to perform combustion in desirable conditions. | 2009-05-07 |
| 20090117506 | Correction Mouthpiece for Ideal Smile - A correction mouthpiece ( | 2009-05-07 |
| 20090117507 | SYSTEMS AND METHODS FOR DENTAL APPLIANCE COMPLIANCE INDICATION - An apparatus for monitoring orthodontic treatment compliance includes an appliance adapted to be worn over one or more teeth; and a compliance indicator mounted on the appliance to indicate compliance. | 2009-05-07 |
| 20090117508 | Adjustable orthodontic apparatus - An adjustable orthodontic apparatus is provided and the apparatus comprises: at least one base plate comprising opposing sides, a first side being a tooth engaging side and a second side comprising a plurality of vertical and horizontal columns of protrusions and plurality of vertical and horizontal channels created by the columns of protrusions; at least one connecting plate having opposing sides, a first side comprising a plurality of vertical and horizontal columns of protrusions and plurality of vertical and horizontal channels created by the columns of protrusions, and the protrusion designed to travel vertically and horizontally within said channel during an adjustment stage; and a securing device for locking said connecting plate to a desired position onto said base plate. | 2009-05-07 |
| 20090117509 | Orthodontic apparatus with self-ligating bracket - An orthodontic bracket is provided, and the orthodontic bracket comprises: a bracket housing having at least two opposing sides, a rear side which is a tooth engaging side and a front side having a cavity for receiving at least one wire; and a cover plate pivotally attached to the front side of the bracket housing, and the cover plate is designed to be moveable from an open to a closed position to secure and hold the wire within said cavity of the front side of the bracket housing. | 2009-05-07 |
| 20090117510 | Orthodontic Apparatus With Self-Ligating Bracket and Locking Device - An orthodontic bracket system is provided, the system comprising a base plate having a rear side and a front side, the rear side designed to engage a patient's tooth, the base plate front side comprising a channel for receiving an archwire; a cover plate for closing the opening of the channel and securing the archwire within the channel of the base plate; and a locking device designed to engage the cover plate during a closed position. | 2009-05-07 |
| 20090117511 | Orthodontic apparatus with adjustable base plate and connecting plate - An adjustable orthodontic apparatus is provided and the apparatus comprises: at least one base plate comprises opposing sides, a first side is a tooth engaging side and a second side comprises a plurality of vertical and horizontal columns of protrusions and plurality of vertical and horizontal channels created by the columns of protrusions; at least one connecting plate having opposing sides, a rear side comprises a plurality of vertical and horizontal columns of protrusions and plurality of vertical and horizontal channels created by the columns of protrusions, the protrusion designed to travel vertically and horizontally within the channel during an adjustment stage, a front side having a cavity for receiving a wire; and a securing device for locking the connecting plate to a desired position onto the base plate. | 2009-05-07 |
| 20090117512 | Orthodontic Instrument For Use With Adjustable Orthodontic Apparatus - An instrument is provided, comprising a handle and at least one working end. In a first embodiment, the working end comprised a first leg and a second leg, the second leg for disengaging a spring clip. In a second embodiment, the working end comprises a first leg and a second leg for grasping a connector plate of an orthodontic bracket, and a depth limiter attached to the first leg for preventing inadvertent grasping of an orthodontic bracket base plate. | 2009-05-07 |
| 20090117513 | CONCURRENT TREATMENT OF ORAL MALADIES USING DIRECT CURRENT ELECTRICITY - A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing direct current electricity. Electrodes are used to deliver a direct current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, perdiodontitis, and oral malodor while also promoting general oral hygiene. | 2009-05-07 |
| 20090117514 | METHOD AND COMPONENTS FOR PRODUCING EDENTULOUS DENTURES - A method and component devices for producing edentulous dentures. The method includes obtaining a cast impression of a jaw, any teeth and gingiva area with a first set of dental trays including selecting a properly sized upper dental tray and a properly sized lower dental tray, applying impression material in each said tray and placing each said dental impression tray with said impression material in said oral cavity in order to deform uncured impression material. A second set of dental trays is utilized including a lower dental tray having a contact plate with an upwardly extending shoulder surrounding a tapered opening, a ball nut retained in the tapered opening, and a post adjustably secured to the ball nut. A striking plate is attached to a second upper dental tray in order to accurately obtain an established occlusal vertical and centric relation positions. A third upper dental tray with a wax impression is inserted for esthetic blue printing to establish the shape of the patient's upper lip and mouth. A third lower dental tray with wax impression material is utilized to determine functional position including tongue, cheek and lip positioning. | 2009-05-07 |
| 20090117515 | INTERPROXIMAL MARKING STRAND - A method and device for marking a natural tooth/bridge, crown or any dental restoration interface to mark high spots on said bridge or crown to be removed during the fitting process using a fiber or filament strand impregnated or otherwise treated with a visual indicating marker material. The marking device may include the use of handheld tool that includes at least one end having a wishbone shaped support for attaching the fiber or filament strand impregnated with the marker material between the wishbone support or having a tool having both ends with wishbone supports, both ends for supporting one or more filaments or strands of material that includes visual markers. | 2009-05-07 |
| 20090117516 | Magnetostrictive insert element for use in a tool holder of an ultrasonic dental treatment device - The invention relates to a magnetostrictive insert element for use in a tool holder of an ultrasonic dental treatment device with at least one first longitudinal section having a dental tool and a coupling element and a second adjoining second longitudinal section with a magnetostrictive ultrasonic converter, the first longitudinal section having a first length and a first weight and the second longitudinal section having a second length and a second weight. The ratio between the first and second length is for example between 0.5 and 0.8. Alternatively or in addition, the ratio between the first and second weight is between 0.1 and 0.3. | 2009-05-07 |
| 20090117517 | Dental crown preparation instrument and method for producing same - A dental crown preparation instrument and method for producing same includes a first body produced by grinding, the first body having a substantially cylindrical shaft and a head connected to the shaft, the first body having outer dimensions being substantially equal to the finished preparation instrument, wherein a basic toothing is at first produced in the head by grinding and a secondary toothing is produced subsequently by grinding, wherein a cutting rate of 15 to 40 m/sec is selected for the grinding process, wherein the grinding wheel is moved with a feed rate of 10 to 50 mm/min and the grinding wheels have diamond particles and have a grain size of 15 to 62 μm, and wherein the toothings have cutting edges featuring a surface roughness of not more than 2.5 μm. | 2009-05-07 |
| 20090117518 | DENTURE TEETH DEVICE AND METHOD - A denture teeth device having a wire, strand or thread, or a plurality of wires adjustably coupled to a plurality of denture teeth to form a unit. The wire may be adjustably coupled along the lingual-apical portions of the denture teeth. The wire may be flexible to permit development of a dental arch form so that the denture teeth can be readily adapted to individual patient needs. The wire may also serve to improve denture tooth retention in a processed denture base. The wire may be adjustably coupled to the denture teeth so as to not constrain the denture teeth along the length of the wire, allowing for customized arrangement of the denture teeth, including the incorporation of denture tooth overlaps, vertical and horizontal discrepancies, diastemata and facial-lingual and mesial-distal angular variation. The apical and lingual portions of the denture teeth may be contoured to facilitate the creation of anatomically realistic and hygienically favorable papilla forms and occlusion or the patient's bite. | 2009-05-07 |
| 20090117519 | STRUCTURAL/BIOLOGICAL IMPLANT SYSTEM - A structural/biological implant and method of use. The implant being utilized as a single or multiple staged system that is designed to encourage new alveolar bone growth with or without the need to obtain autologous bone. The implant has an apical portion that is fastened into existing bone, with the remainder of the implant left outside of existing bone. The exposed portion of the implant may have an external shape or configuration with a variety of attached and/or integrally formed mechanical retention and stability elements. Osteotropic/angiotropic material may be associated with the implant to induce and or conduct new bone growth and possible vascularization, thus, rather than fitting the implant into the bone, the bone is grown integratively with the implant. The osteotropic/angiotropic materials may be simultaneously placed with the staged implant to provide consistent stabilization for the materials and to provide an immediately available surface for bone cell adhesion and growth. The invention thus allows implants to be used in location where the volume and/or shape of the bone would not be adequate for existing implant systems. | 2009-05-07 |
| 20090117520 | IMPLANT KEEPER AND ITS ASSEMBLY, AND KEEPER-FIXING METHOD - A keeper for an implant comprising a keeper body made of a soft-magnetic material, which has a recess for receiving an abutment head having an internally threaded hole, and an internally threaded hole extending along its center axis in communication with the recess, and a screw member threadably engageable with the internally threaded holes of the keeper body and the abutment, whereby the keeper body is tightly fastened to the abutment by tension exerted by the screw member threadably engaging the internally threaded holes of the keeper body and the abutment. | 2009-05-07 |
| 20090117521 | Dental Implant Assembly With Internal Connection - Dental implant assembly with internal connection comprising an implant ( | 2009-05-07 |
| 20090117522 | System to whiten interproximal surfaces of adjacent teeth - A method to whiten contacting interproximal mesial and distal surfaces of a pair of adjacent teeth includes the steps of providing a carrier shaped and dimensioned to be inserted between the pair of adjacent teeth, to fit between and separate the interproximal mesial and distal surfaces, and to contact each of the interproximal mesial and distal surfaces; charging the carrier with a tooth whitening composition; inserting the carrier intermediate the pair of adjacent teeth; and, manipulating the carrier to separate the contacting interproximal mesial and distal surfaces and to deliver the tooth whitening composition to the interproximal mesial and distal surfaces by contacting simultaneously the interproximal mesial and distal surfaces with said carrier to contact each of the interproximal mesial and distal surfaces with a portion of the tooth whitening composition on the carrier. | 2009-05-07 |
| 20090117523 | Optical hand drawing plate - An optical hand drawing plate includes a body and a backlight module. The body has a concave portion and an input portion corresponding to one side of the concave portion. The backlight module is mounted in the concave portion and includes a light guide plate, a background plate and a light emitting assembly. An insertion space is formed between the light guide plate and the background plate and corresponds to the input portion. Basing on the structure of the present invention, a picture can be inserted in the insert space between the light guide plate and the background plate through the input portion, and a user can directly draw patterns shown on the picture. A light source is provided for the light guide plate via the light emitting assembly, thereby the optical hand drawing plate has a special visual effect. | 2009-05-07 |
| 20090117524 | METHOD OF ENHANCING THE LEARNING OF INNOVATION - A method of enhancing learning at a learning institution about innovation and the protection of intellectual property comprises establishing a course in innovation and/or intellectual property protection at the learning institution. Students desiring to register for the course at the learning institution may be required to assign to an entity designated by the learning institution any intellectual property right that student might achieve by reason of that student being allowed register to take the course. Students constituting a class taking the course conceive an innovation and learn about innovation and how to protect innovative intellectual property by participating in a patent application (or other intellectual property application) that is filed at a patenting authority on the innovation conceived as a result of the class taking the course being offered at the learning institute, and at least one student registered for the course is a named inventor on the application. | 2009-05-07 |
| 20090117525 | Sensory Coordination System for Sports, Therapy and Exercise - A sensory coordination system for sports, occupational therapy, physical therapy and general exercise. | 2009-05-07 |
| 20090117526 | Arrangement for Auscultation Training - A cap composition that can mechanically attach to a stethoscope headpiece, the cap composition having a cap; a cap element having a design that includes a shape and characteristic dimensions that enable the cap to mechanically attach to a stethoscope headpiece; and a speaker attached to and positioned on or at least partially within the cap, such that when the cap is attached to the stethoscope headpiece, the speaker is either touching or proximate to the stethoscope diaphragm such that a sound or signal emitted by the speaker can cause the stethoscope diaphragm to vibrate. | 2009-05-07 |
| 20090117527 | Auscultation Training Device and Related Methods - A cap composition that can mechanically attach to a stethoscope headpiece, the cap composition having a cap; a cap element having a design that includes a shape and characteristic dimensions that enable the cap to mechanically attach to a stethoscope headpiece; and a speaker attached to and positioned on or at least partially within the cap, such that when the cap is attached to the stethoscope headpiece, the speaker is either touching or proximate to the stethoscope diaphragm such that a sound or signal emitted by the speaker can cause the stethoscope diaphragm to vibrate. | 2009-05-07 |
| 20090117528 | Hybrid reading materials and methods for mentally investing readers in reading materials - Hybrid reading materials and methods for mentally investing readers in reading materials. Hybrid reading materials include text reciting written subject matter adapted to be read visually and an audio source operatively coupled to the text, the audio source including a memory device configured to store spoken presentation data, the spoken presentation data supplementing the text and being distinct from the written subject matter. Methods for mentally investing a reader in a reading material include providing a reader with a summary document which summarizes aspects of the reading material and providing the reader with a spoken presentation of subject matter related to the reading material. | 2009-05-07 |
| 20090117529 | Grant administration system - A method and system are disclosed for facilitating the completion of a questionnaire. A storage medium stores a plurality of questions and associated answers. Similar questions are linked. An interface presents to a user through a computer network a presented question as part of a questionnaire to be completed. The interface also presents to the user answers associated with similar questions linked to the presented question. Upon user selection, an answer to a similar question is stored as an answer to the selected question. The user may modify the answer. The method and system may present additional questions and answers associated with similar questions linked to the additional question. A user may have access to stored questions, add questions, and link similar questions. Answers to questions may be stored before the user completes the questionnaire. The questionnaire may include fields populated with information previously supplied by the user without user selection. The storage medium may be a database. | 2009-05-07 |
| 20090117530 | SYSTEMS AND METHODS FOR IMPROVING MEDIA FILE ACCESS OVER A NETWORK - Systems and methods are disclosed for serving fresh media content while minimizing Internet traffic by periodically checking content freshness between a local server and a remote server; if a stale content exists on the local server, replacing the stale content with a fresh content from the remote server; and serving the fresh content from the local server. | 2009-05-07 |
| 20090117531 | CLOTHES FOR INFANT EDUCATION - As for clothes for infant according to the present invention, it consists of and is characterized as followings: the base part embodied to be able to be detachably attached on surface of clothes; the educational auxiliary member detachably attached on the above base part but having a shape among as a plane or a solid body including a educational contents which consists of any of character, picture, digit, and shape and contains education content for infant and; a coupling auxiliary member which consists of any of a button, a velcro tape, a zipper, a magnet, a hook, and combination of a projected rod and a coupling groove and also, provides coupling ability of attachment and detachment on any of the above clothes and the above base part, or any of the above base part and the above educational auxiliary member. | 2009-05-07 |
| 20090117532 | Pre-clinical method for monitoring serial changes in circulating breast cancer cells in mice - The CellTracks® System provides a system to enumerate CTC's in blood. The system immunomagnetically concentrates epithelial cells, fluorescently labels the cells and identifies and quantifies CTC's. The absolute number of CTC's detected in the peripheral blood tumor load is, in part, a factor in prediction of survival, time to progression, and response to therapy. Pre-clinical studies of circulating tumor cells (CTC's) have been limited by the inability to repetitively monitor CTC's in animal models. The present invention provides a method to enumerate CTC's in blood samples obtained from living mice, using a protocol similar to an in vitro diagnostic system for quantifying CTC's in patients. Accordingly, this technology can be adapted for serial monitoring of CTC's in mouse xenograft tumor models of human breast cancer. | 2009-05-07 |
| 20090117533 | Apparatus For Producing And Handling A Flowing Substance | 2009-05-07 |
| 20090117534 | COMPOSITIONS AND ASSAYS UTILIZING ADP OR PHOSPHATE FOR DETECTING PROTEIN MODULATORS - Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials. | 2009-05-07 |
| 20090117535 | Method for identifying HIV-1 protease inhibitors with reduced metabolic affects - The invention provides a novel in vitro method for identifying HIV-1 protease inhibitors with reduced potential for inducing metabolic abnormalities. The invention further provides diagnostic methods for identifying patients who may be at risk of developing metabolic abnormalities subsequent to the administration of an HIV-1 protease inhibitor. The invention also provides novel polynucleotides associated with the incidence of HIV-1 protease inhibitor induced metabolic abnormalities. The invention also provides polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides which comprise at least one polymorphic locus per fragment. Allele-specific primers and probes which hybridize to these regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, medicine, and genetic analysis. The invention further relates to diagnostic methods for using these novel polynucleotides in the diagnosis, treatment, and/or prevention of HIV-1 protease inhibitor induced metabolic abnormalities. | 2009-05-07 |
| 20090117536 | METHOD AND DEVICE FOR BACTERIAL SAMPLING - A bacterial detection sampling device comprising: a sampling medium for receiving a bacterial sample; and a plurality of bacteriophage. The bacteriophage are located on or in the sampling medium. Each bacteriophage comprises a nucleic acid encoding a protein capable of emitting light at an output wavelength. | 2009-05-07 |
| 20090117537 | METHOD FOR DETECTING SARS CORONAVIRUS - This invention provides: a method for detecting SARS pathogenic viruses with high sensitivity and rapidity for diagnosing severe acute respiratory syndrome (SARS); an oligonucleotide primer that can specifically hybridize with any nucleotide sequence constructed based on the nucleotide sequence of RNA polymerase of the SARS coronavirus; a method for nucleic acid amplification using such primer; a method for diagnosing infection with the SARS coronavirus via detection of nucleic acid amplification; and a kit for diagnosing SARS. | 2009-05-07 |
| 20090117538 | Methods for Obtaining Gene Tags - The present invention provides methods for providing as tags the nucleotide sequences at the 5′ end of mRNA. The method of the present invention comprises the step of synthesizing cDNA using, as a template, mRNA whose CAP structure is linked with a IIs linker having a type IIs endonuclease recognition sequence. Tags including the nucleotide sequence from the 5′ end of mRNA are generated by reacting the type IIs endonuclease to cDNA. Tags can be generated from all mRNA, independently of their nucleotide sequences. Methods for identifying transcriptional start sites and primers for full-length cDNA synthesis are provided based on the nucleotide sequence information of tags of the present invention. | 2009-05-07 |
| 20090117539 | DNA sequences for gene suppression - The present invention provides methods of improving DNA sequences for gene suppression mediated by double-stranded RNA, and constructs and transgenic organisms containing such improved DNA sequences. | 2009-05-07 |
| 20090117540 | Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase - The invention relates to compositions and methods for generating a signal indicative of the presence of a target nucleic acid in a sample, where the compositions and methods include an RNA polymerase, a FEN nuclease, and a probe. | 2009-05-07 |
| 20090117541 | METHODS OF DETECTING TPMT MUTATIONS - Methods and compositions are described for use in the rapid and simultaneous screening of one or more samples for one or more mutations in the TPMT gene. The methods and compositions of the present invention can be used to rapidly determine if a mutation of the TPMT gene is present in the genome of a subject. Identifying which mutations are present in an individual allows the clinician to design an appropriate therapy using drugs metabolized by TPMT for that individual. | 2009-05-07 |
| 20090117542 | UNIQUE SHORT TANDEM REPEATS AND METHODS OF THEIR USE - Methods for DNA fingerprinting identification of human DNA samples, comprising: a) exposing a DNA sample of an individual to at least one primer specific for a Y chromosome polymorphism at a predetermined loci, said loci being chosen from OSU9, OSU14, OSU22, OSU35, OSU51, OSU57, OSU67, OSU70, OSU73, OSU77, with the proviso that if OSU70 is selected then at least one other OSU locus is also selected; b) amplifying DNA of the DNA sample using the at least one primer specific for a Y chromosome polymorphism; and c) identifying the size of an amplified product. Primers for the methods are also provided. | 2009-05-07 |
| 20090117543 | METHODS AND COMPOSITIONS FOR INDUCING SIRTUINS - Provided herein are compositions comprising agents that increase the level of expression of a sirtuin gene. Also provided are methods for purifying and isolating a factor from serum that stimulates the expression of a sirtuin gene. Diagnostic methods for determining whether a subject is calorically restricted or resistant to stress are also provided. | 2009-05-07 |
| 20090117544 | METHOD OF DESIGNING PRIMERS FOR USE IN METHOD OF DETECTING TARGET NUCLEIC ACID AND ASSAY KIT - A method of designing primers for use in a method of detecting an amplification product by hybridizing it with a probe, the amplification product is amplified from a target nucleic acid with the primers, including placing F3, F2 and F1 regions in this order from a 5′ terminal side and Bc, B2 | 2009-05-07 |
| 20090117545 | Glycine riboswitches, methods for their use, and compositions for use with glycine riboswitches Cross-Reference to Related Applications - It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified versions of these natural “riboswitches” (created by using various nucleic acid engineering strategies) can be employed as designer genetic switches that are controlled by specific effector compounds. Such effector compounds that activate a riboswitch are referred to herein as trigger molecules. The natural switches are targets for antibiotics and other small molecule therapies. In addition, the architecture of riboswitches allows actual pieces of the natural switches to be used to construct new non-immunogenic genetic control elements, for example the aptamer (molecular recognition) domain can be swapped with other non-natural aptamers (or otherwise modified) such that the new recognition domain causes genetic modulation with user-defined effector compounds. The changed switches become part of a therapy regimen-turning on, or off, or regulating protein synthesis. Newly constructed genetic regulation networks can be applied in such areas as living biosensors, metabolic engineering of organisms, and in advanced forms of gene therapy treatments. | 2009-05-07 |
| 20090117546 | Disease detection by digital protein truncation assays - Genetic diseases can be diagnosed by detection of mutations in causative genes. Protein truncation assays can be used to detect gene products of truncation-type mutations. However, the sensitivity of the assays is often insufficient to detect mutations present in a sample of DNA at a low frequency. Sensitivity can be increased by dividing samples so that the signal generated by a mutant allele comprises a larger fraction of the total alleles than prior to dividing. Thus a previously undetectable signal generated by the mutant allele can become detectable in the assay. Such increased sensitivity permits detection at early stages and in samples having high levels of other alleles. | 2009-05-07 |
| 20090117547 | NOVEL HAPLOTYPE OF HUMAN T2R RECEPTOR hT2R50 AND ITS USE IN ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS - The present invention relates to the discovery of a novel haplotype of the human taste receptor hT2R50 in the T2R taste receptor family that responds to particular bitter ligands, i.e., 2-acetylpyrazine and ethylpyrazine. The present invention also relates to the use of this novel haplotype in assays for identifying ligands that modulate the activation of the hT2R50 taste receptor. These compounds potentially may be used as additives in foods, beverages and medicinals for modifying (blocking) hT2R50-associated bitter taste. | 2009-05-07 |
| 20090117548 | ANALYSIS OF HIV-1 CORECEPTOR USE IN THE CLINICAL CARE OF HIV-1 INFECTED PATIENTS - A change in viral tropism occurs in many HIV positive individuals over time and can be indicated by a change in coreceptor usage from CCR5 to CXCR4. The change in coreceptor usage to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations of virus can be shifted back to CCR5-mediated entry after the CXCR4-specific strains have emerged. The present invention relates to a diagnostic method to monitor coreceptor use in the treatment of human immunodeficiency virus (HIV) infection. The present invention further relates to a diagnostic method applied to HIV-positive individuals undergoing HAART to monitor the suppression of CXCR4 specific strains. The diagnostic methods can be used to assist in selecting antiretroviral therapy and to improve predictions of disease prognosis over time. | 2009-05-07 |
| 20090117549 | Aptamer-based methods for identifying cellular biomarkers - In this invention, a biomarker discovery method has been developed using specific biotin-labeled oligonucleotide ligands and magnetic streptavidin beads. In one embodiment, the oligonucleotide ligands are firstly generated by whole-cell based SELEX technique. Such ligands can recognize target cells with high affinity and specificity and can distinguish cells that are closely related to target cells even in patient samples. The targets of these oligonucleotide ligands are significant biomarkers for certain cells. These important biomarkers can be captured by forming complexes with biotin-labeled oligonucleotide ligands and collecting the complexes using magnetic streptavidin beads, whereupon the captured biomarkers are analyzed to identify the biomarkers. Analysis of biomarkers include HPLC-Mass Spectroscopy analysis, polyacrylamide gel electrophoresis, flow cytometry, and the like. The identified biomarkers can be used for pathological diagnosis and therapeutic applications. Using the disclosed methods, highly specific biomarkers of any kinds of cells, in particular cancer cells, can easily be identified without prior knowledge of the existence of such biomarkers. | 2009-05-07 |
| 20090117550 | Assessing brain aneurysms - This document provides methods and materials related to assessing brain conditions within mammals. For example, methods and materials that can be used to determine whether or not a mammal (e.g., a human) with a brain aneurysm is likely to experience brain aneurysm rupture are provided. | 2009-05-07 |
| 20090117551 | METHOD FOR SIMULTANEOUS ANALYSIS OF MULTIPLE BIOLOGICAL REACTIONS OR CHANGES IN IN VIVO CONDITIONS - It is an object of the preset invention to provide an activity measurement molecule necessary for measuring biological reactions or changes in in vivo conditions, and a method for measuring activity using the above activity measurement molecule. It is intended to provide an activity measurement molecule used for simultaneously analyzing multiple biological reactions and/or changes in in vivo conditions, which is characterized in that one or more fluorescent molecule-labeled and/or -unlabeled biomolecules used as targets of the biological reactions or changes in in vivo conditions bind onto a quantum dot, and a method for simultaneously analyzing multiple biological reactions and/or changes in in vivo conditions using the above activity measurement molecule. | 2009-05-07 |
| 20090117552 | Method for Detection and Quantification of Target Nucleic Acids in a Sample - The present invention relates to methods for multiplex detection and quantification of target nucleic acid sequences in a sample comprising the steps of: (i) providing a solid support having immobilized thereon an array of detector oligonucleotides, wherein said array of detector oligonucleotides is designed by random selection of non-eukaryotic genomic sequences followed by random selection of oligonucleotide sequences and subsequent conversion of these oligonucleotide sequences such that these are composed of only three types of nucleotides; (ii) providing a sample having added thereto a fixed amount of control nucleic acid of known sequence; (iii) contacting said sample with at least two probes that hybridise to adjacent sites of a target sequence under conditions favouring hybridisation between the sample nucleic acids and the said at least two probes, wherein, a) a first probe is composed of a 5′ end sequence part for hybridisation to a PCR primer and a 3′ end sequence part for hybridisation to the target nucleic acid; and b) a second probe is composed of a 5′ end sequence part for hybridisation to the target nucleic acid, and a 3′ end sequence part for hybridisation with a PCR primer, and c) an intermediate sequence is present in between said 5′ and 3′ end sequence parts of said first or second probe; and d) said second probe is characterized by having 5′ phosphate group allowing ligation with a 3′ hydroxyl group at the said first probe forming a ligation-mediated probe; (iv) ligation of the said hybridised first and second probes to form ligation-mediated probes; (v) contacting a set of detectable labelled PCR primers with the ligation-mediated probes allowing amplification thereof; (vi) detection and quantification of sample nucleic acids via hybridisation of the said intermediate parts within the amplified ligation-mediated probes onto the array of detector oligonucleotides provided in The present invention also relates to the use of said methods as well as microarrays and kits for performing said methods. | 2009-05-07 |
| 20090117553 | NUCLEIC ACID MELTING ANALYSIS WITH SATURATION DYES - Methods are provided for nucleic acid analysis wherein a target nucleic acid is mixed with a dsDNA binding dye to form a mixture. Optionally, an unlabeled probe is included in the mixture. A melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye as the mixture is heated. Dyes for use in nucleic acid analysis and methods for making dyes are also provided. | 2009-05-07 |
| 20090117554 | POLYNUCLEOTIDE AND PROTEIN INVOLVED IN SYNAPTOGENESIS, VARIANTS THEREOF, AND THEIR THERAPEUTIC AND DIAGNOSTIC USES - The invention relates to a method and a kit for diagnosing autism linked to a mutation in a protein belonging to the family of human neuroligins. | 2009-05-07 |
| 20090117555 | Microfluidic Flow Lysometer Device, System and Method - The invention provides a device, system and method that enables a microfluidic flow lysometer cell analyzer. Using a population of suspended living cells. cell surface molecule detection reagents, and cell cytoplasm (or nuclear) molecule detection reagents, this microfluidic cell analyzer can rapidly analyze a population of cells by running them on a one-at-a-time basis through small capillary channels. The cell's morphology or surface markers are analyzed, then the cells are lysed, and the molecules present in the cell's cytoplasm or nuclear material are analyzed. Cell morphology is then analyzed as the cell surface molecules are correlated with the molecules present in the same cell's cytoplasm or nucleic acids, and this correlated cell population data is then presented to a user for interpretation. The invention also addresses issues such as device fouling, correction for experimental artifacts (incomplete cell lyis, variable cell debris volume effects), and inadequate data collection that hampered earlier efforts in this area. | 2009-05-07 |
| 20090117556 | Association of Single Nucleotide Polymorphisms in the CBFA2T1 and DECR1 Genes with Performance and Carcass Merit of Beef Cattle - Aspects of the present invention also provide novel compositions and methods based on novel CBFA2T1 and/or DECR1 single nucleotide polymorphisms selected from the group consisting of CBFA2T1 SNP1, CBFA2T1 SNP2, CBFA2T1 SNP3, CBFA2T1 SNP4, DECR1 SNP5, DECR1 SNP6, DECR1 SNP7, DECR1 SNP8, DECR1 SNP9, DECR1 SNP10, DECR1 SNP11, DECR1 SNP12 and DECR1 SNP13, which may provide novel markers for carcass quality, growth and/or feed efficiency. Additional aspects provide for novel methods which may comprise marker-assisted selection or marker-assisted management to improve carcass quality, growth and/or feed efficiency in cattle. | 2009-05-07 |
| 20090117557 | Rapid Detection of Microorganisms - Tools and methods for detecting the presence bacteria, yeast and mold in a sample obtained from a food sample are provided. The methods employ a polymerase chain reaction and primer and probe sets that are based on the 16S rRNA and squalene-hopene cyclase genes of | 2009-05-07 |
| 20090117558 | Method for improved specificity in probe based assays - Disclosed are compositions and methods for analyzing a target sequence in a sample. Generally, the method includes use of at least one pair of probes (Probe A and Probe B). In one embodiment, Probe A hybridizes to wanted and unwanted nucleic acid in the sample and bears a fluorophore and Probe B hybridizes to unwanted nucleic acid in the sample and bears a quencher. Fluorescence signal from Probe A hybridizing to unwanted nucleic acid is quenched by any relatively close hybridization of Probe B hereby increasing the specificity for the presence, amount or absence of the wanted target sequence. In preferred embodiments, the method is referred to as Fluorescence In-Situ Hybridization (FISH). The invention has many useful applications including rapidly detecting a microbial target sequence in a clinical sample. | 2009-05-07 |
| 20090117559 | Methods for Determining Probability of an Adverse or Favorable Reaction to a Niacin Receptor Agonist - The present invention relates generally to a GPR109A niacin receptor. The present invention relates more particularly to assessing a GPR109A polymorphism in an individual, wherein the GPR109A polymorphism is indicative of the subject's risk for an adverse reaction to the administration of a GPR109A receptor agonist, wherein the adverse reaction is associated with stimulation of MAP kinase activity by the GPR109A receptor agonist. More specifically, the present invention relates to assessing a GPR109A polymorphism in an individual and determining the level of risk for the subject for experiencing an adverse reaction, wherein the subject's GPR109A zygosity is predictive of the risk for a cutaneous flushing response that can be experienced following administration of a GPR109A receptor agonist. | 2009-05-07 |
| 20090117560 | Method of Forming Self Assembly Substance on Microsphere and Method of Detecting Target Analyte - It is intended to provide a method, in which the sensitivity in detecting a target analyte on a microsphere can be elevated and plural items can be detected at the same time. The presence of at least one target analyte in a sample is detected by bonding a microsphere having a fluorescent substance on the surface and the target analyte to a self assembly substance formed by using two oligonucleotide probes having complementary base sequence regions which are hybridizable with each other via the target analyte, thus forming a self assembly substance-bonded particle, and then analyzing the self assembly substance-bonded particle. | 2009-05-07 |
| 20090117561 | DIFFERENTIAL EXPRESSION GENE PROFILES AND APPLICATIONS IN MOLECULAR STAGING OF HUMAN GASTRIC CANCER - The invention provides methods for detecting differential gene expression in intestinal gastric tissue in a mammal by comparing the expression of specific genes in an intestinal gastric tissue suspected of being cancerous with that of the corresponding adjacent intestinal gastric tissue or a normal gastric mucosa tissue. The methods can be used in diagnosing or monitoring the progression of intestinal gastric cancer and determining the levels of differentiation of intestinal gastric cancer Systems and kits for methods of the invention are also provided. | 2009-05-07 |
| 20090117562 | Method and kit for diagnosing Autism using gene expression profiling - This invention relates to DNA microarray technology, and more specifically to methods and kits for identifying autism and autism spectrum disorders in humans. | 2009-05-07 |
| 20090117563 | Identification of TRPML3 (MCOLN3) as a Salty Taste Receptor and Use in Assays for Identifying Taste (Salty) Modulators and/or Therapeutics that Modulate Sodium Transport, Absorption or Excretion and/or Aldosterone and/or Vasopressin Production or Release - This invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals (given the significance of sodium and other ions to physiological functions and conditions this phenotype is likely strongly conserved in different animals). The invention also relates to the discovery that the TRPML3 gene also modulates one or more of sodium metabolism, sodium excretion, blood pressure, fluid retention, cardiac function and urinary functions such as urine production and excretion. The invention also relates to transgenic animals that have been engineered to express or knock out TRPML3 expression and assays using TRPML3 expressing animals, cells and isolated ion channel polypeptides for identifying compounds that modulate TRPML3-associated functions including salty taste, sodium metabolism, sodium excretion, blood pressure, fluid retention, cardiac function and urinary functions such as urine production and excretion. | 2009-05-07 |
| 20090117564 | ESTROGEN RECEPTOR GENES AND UTILIZATION THEREOF - An estrogen receptor gene and utilization of the estrogen receptor gene. The estrogen receptor gene contains a nucleotide sequence coding for any of the following amino acid sequences: (a) the amino acid sequence of SEQ ID NO:1, (b) the amino acid sequence of SEQ ID NO:4, (c) the amino acid sequence of SEQ ID NO:23, (d) an amino acid sequence exhibiting 95% or more amino acid identity to the amino acid sequence of SEQ ID NO:1, (e) an amino acid sequence exhibiting 95% or more amino acid identity to the amino acid sequence of SEQ ID NO:4, and (f) an amino acid sequence exhibiting 85% or more amino acid identity to the amino acid sequence of SEQ ID NO:23. | 2009-05-07 |
| 20090117565 | Compositions and methods for diagnosis and treating mood disorders - The present invention provides methods for diagnosing mental disorders such as mood disorders, including bipolar disorder I and II and major depression; The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering from such mental disorders. | 2009-05-07 |
| 20090117566 | Compositions and methods for the diagnosis and treatment of tumor - The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. | 2009-05-07 |
| 20090117567 | EUBACTERIAL tmRNA SEQUENCES AND USES THEREOF - The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays. | 2009-05-07 |
| 20090117568 | EUBACTERIAL tmRNA SEQUENCES AND USES THEREOF - The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays. | 2009-05-07 |
| 20090117569 | EUBACTERIAL tmRNA SEQUENCES AND USES THEREOF - The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays. | 2009-05-07 |
| 20090117570 | EUBACTERIAL tmRNA SEQUENCES AND USES THEREOF - The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays. | 2009-05-07 |
| 20090117571 | IMPEDANCE SPECTROSCOPY OF BIOMOLECULES USING FUNCTIONALIZED NANOPARTICLES - A biosensor system includes a functionalized interdigitated electrode, functionalized nanoparticles, a current/voltage signal generator, and a circuit analyzer. The interdigitated electrode can be functionalized by coating an exposed surface with first biomolecular probes. The nanoparticles are functionalized by coating an outer surface with second biomolecular probes. A signal generator provides a signal (e.g., an alternating current or voltage) having a selected range of frequencies. A circuit analyzer analyzes electrical parameters of the circuit as the signal is applied. Sensitivity is increased by the presence of functionalized nanoparticles in the system. An analytic method includes measuring changes in electrical parameters of the circuit over the range of frequencies. Using these measurements, the biosensor system can determine whether a target biomolecule is bound. The biosensor system can also identify a biomolecule by comparing the detected signal or “electro-fingerprint” with a reference set of signals over the frequency range. | 2009-05-07 |
| 20090117572 | Cell-Based Fluorescence Resonance Energy Transfer (FRET) Assays For Clostridial Toxins - The present invention provides a method of determining clostridial toxin activity by (a) contacting with a sample a cell containing a clostridial toxin substrate that includes a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence containing a cleavage site that intervenes between the donor fluorophore and the acceptor, where resonance energy transfer is exhibited between the donor fluorophore and the acceptor under the appropriate conditions; (b) exciting the donor fluorophore; and (c) determining resonance energy transfer of the contacted cell relative to a control cell, where a difference in resonance energy transfer of the contacted cell as compared to the control cell is indicative of clostridial toxin activity. | 2009-05-07 |
| 20090117573 | Locus specific amplification using array probes - Methods are provided for multiplexed amplification of selected targets and analysis of the amplified targets. In preferred aspects the amplification and analysis take place on the same solid support and preferably in a localized area such as a bead or a feature of an array. In preferred aspects the analysis is a determination of sequence at one or more locations in the amplified target. The methods may be used for genotyping, sequencing and analysis of copy number. | 2009-05-07 |
| 20090117574 | SELF-ACTUATING SIGNAL PRODUCING DETECTION DEVICES AND METHODS - An assay system is provided of great sensitivity and portability where the presence of a specific target in a sample, as well as its concentration (qualification and quantification) is detected by reason of a potential or voltage in a closed circuit, built up a redox reaction. The reaction is produced by binding a capture moiety to an enzymatic redox reaction partner, allowing the capture moiety to bind to any target in the sample, and washing any such bound target. The bound target, if not immobilized, may be immobilized through use of a second capture moiety. Substrate for the enzyme is then added. The action of the enzyme upon the substrate frees electrons, creating a potential across an anode and cathode which may be separated by a membrane. | 2009-05-07 |
| 20090117575 | Detection Probe Acting by Molecular Recognition - The present invention relates to a detection probe acting by molecular recognition of a target sequence, comprising successively in the 5′-3′ direction:
| 2009-05-07 |
| 20090117576 | METHODS FOR ANALYZING NUCLEIC ACID - The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification). | 2009-05-07 |
| 20090117577 | METHODS TO IDENTIFY COMPOUNDS USEFUL FOR TUMOR SENSITIZATION TO DNA DAMAGE - Cdc25A is herein identified as a substrate for β-TrCP1- or β-TrCP2-mediated ubiquitination and subsequent degradation via the ubiquitin-proteasome pathway. In particular, it has been found that interfering with β-TrCP expression or function, or increasing β-TrCP degradation, leads to accumulation of Cdc25A in a cell. Since degradation of Cdc25A is a key feature of the response to DNA damage, leading to a stall in the cell cycle during which the cell can repair the damage, Cdc25A accumulation can abolish this response, thereby sensitizing the cell to DNA damage. Described herein are assays for identifying β-TrCP inhibitors, and method of using such inhibitors for modulating Cdc25A degradation, sensitization of tumor cells, and as adjuvants in cancer therapy based on DNA damaging agents. | 2009-05-07 |
| 20090117578 | Method for identifying type I diabetes mellitus in humans - A method and system for classifying subject populations utilizing predictive and diagnostic biomarkers for type I diabetes mellitus. The method including determining the levels of a variety of markers within the serum or plasma of a target organism and correlating this level to general populations as a screen for predisposition or progressive monitoring of disease presence or predisposition. | 2009-05-07 |
| 20090117579 | Relating To The Handling Of DNA - A variety of methods are provided which use a silicon or silicon dioxide channel to extract DNA from a sample and then release it at a later point. The extraction channels are simple to manufacture and reliable in use. Prior art problems with entrainment of gas, liquid and solid material within channels are addressed. The techniques provide a convenient way of controlling the amount or concentration of DNA in the eluant. | 2009-05-07 |
| 20090117580 | Structure of prl-1 protein crystal and the method of crystallization thereof - The present invention relates to a crystal structure of PRL-1 (Phospatase of Regenerating Liver) protein and a method of crystallization thereof. It has been found that the PRL-1 protein has a tertiary structure having 5 strands of beta-sheet surrounded by 6 alpha-helices and well-arranged active site with closed P-loop, and monomers form a trimer through farnesylation site in the C-terminus of said protein. Thus intra-cellular migration and membrane localization can be achieved. The said crystal structure of PRL-1 protein of the present invention is very useful for the development the agent which inhibits carcinogenesis and metastasis of the cancer. | 2009-05-07 |
| 20090117581 | Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS) - The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. | 2009-05-07 |
| 20090117582 | Diagnosis of Allergic Complaints, Atopic Diseases and/or Auto-Immune Diseases by the Identification of Antibodies Against CD28 in Human Serum - The invention relates to a method for diagnosing allergic complaints, atopic diseases and/or auto-immune diseases, according to which a sample from a patient is analysed for the presence of anti-CD28 auto-antibodies by bringing said sample into contact with CD28. If auto-antibodies bond to the CD28, this indicates the presence of an allergic complaint, atopic disease and/or auto-immune disease. The invention also relates to the use of CD28 for diagnosing said diseases and to a kit that is designed for this purpose, comprising CD28 and marked anti-immunoglobulin antibodies. | 2009-05-07 |
| 20090117583 | EGF-like nucleic acids and polypeptides and uses thereof - The invention provides isolated nucleic acid molecules, designated ELVIS-1, ELVIS-2, and ELVIS-3 (for Epidermal Growth Factor-Like Variant In Skin-1,2, and 3). ELVIS nucleic acid molecules encode wholly secreted and transmembrane proteins with homology to EGF and TGF-α. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes. | 2009-05-07 |
| 20090117584 | Non-Human mammalian Arthritis Model Featuring Human Antibodies Against Citrul-Linated Proteins - Use of a non-human mammalian disease model, wherein the non-human mammal has been implanted with human synovial tissue or other human inflamed tissue containing anti-CCP (cyclic citrullinated peptide) antibody producing cells for (i) analyzing cellular processes in a disease associated with anti-CCP antibodies in such human synovial tissue or other human inflamed tissue, (ii) studying the role of anti-CCP antibodies in the induction and progression of a disease associated with anti-CCP antibodies, (iii) testing the efficacy of a therapeutic agent for the prevention or treatment of a disease associated with anti-CCP antibodies, and (iv) identifying a therapeutic agent useful for the prevention or treatment of a disease associated with anti-CCP antibodies. In one embodiment the non-human mammalian disease model is a mouse, such as a SCID mouse, and the disease associated with anti-CCP antibodies is arthritis, such as RA (rheumatoid arthritis). | 2009-05-07 |
| 20090117585 | ANTI-FUNGAL SCREENING METHOD - The present invention relates to a method for identification of anti-fungal agents and their mode of actions. In particular, it relates to cell wall disturbing anti-fungal agents and to an assay to identify them. More particularly, it relates to a screening method for the identification of an anti-fungal compound, which method comprises (i) contacting a potential anti-fungal compound with a polypeptide which is involved in cell wall synthesis; and then (ii) identifying the effect which the potential anti-fungal compound has on the activity of the polypeptide, whereby reduced polypeptide activity is indicative for anti-fungal activity of the potential anti-fungal compound. It also relates to an overexpressing host cell and to a kit for performing the assay. | 2009-05-07 |
| 20090117586 | FUNGAL CELL WALL SYNTHESIS GENE - A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved. | 2009-05-07 |
| 20090117587 | High-Affinity Monoclonal Antibodies for Botulinum Toxin Type A - High affinity antibodies for binding epitopes of BoNT/A and hybridomas that produce such antibodies are described. The antibodies may be used in a kit for detecting BoNT/A in a sample. | 2009-05-07 |
| 20090117588 | Methods of diagnosing pre-eclampsia or eclampsia - Disclosed herein are kits for diagnosing pre-eclampsia and eclampsia or a propensity to develop pre-eclampsia or eclampsia that include agents for the detection of levels of free placental growth factor in a subject. | 2009-05-07 |
