18th week of 2012 patent applcation highlights part 59 |
Patent application number | Title | Published |
20120108419 | ABSORBENT CORE - An absorbent core for an absorbent article comprising from 1 to 2000 mg of a not cross linked polycarboxylic acid based polymer having an average molecular weight between 1000 and 25000 Da. | 2012-05-03 |
20120108420 | Polysulfide-rubber-coated activated carbon (PSR-AC) as a multi-sorbent for mercury and polychlorinated biphenyls (PCBS) - A toxin immobilization particle and method of fabrication is provided that includes a polysulfide-rubber polymer coated activated carbon particle that provides enhanced toxin adsorption. A porous activated carbon particle have a size range up to 2 mm is used. The polysulfide-rubber polymer coated activated carbon particle includes a polymer-dose range of up to 1.64 grams of sulfur per gram of activated carbon particles, where the toxins can include mercury, PCBs, chlorinated pesticides or polycyclic aromatic hydrocarbons. The method of forming the toxin immobilization particle includes condensing a polymer in a sulfide mixture to form a polysulfide-rubber polymer compound and coating an activated carbon particle with the polysulfide-rubber polymer. The levels of sulfur loading in the toxin immobilization particles are controlled by the polymer dose during the coating process, where the polysulfide polymer coated activated carbon particle provides enhanced toxin adsorption. | 2012-05-03 |
20120108421 | Absorbent composite material and method for manufacturing the same - An absorbent composite comprising: a base material and water-absorbent resin particles; wherein the following conditions (1) to (4) are fulfilled: (1) the weight ratio of water-absorbent resin relative to the total weight of the base material and water-absorbent resin is 65 to 99 wt %, (2) the water-absorbent resin particles adhering directly to the base material constitute 50 wt % or more of the total water-absorbent resin particles; (3) the average absorption capacity of the water-absorbent resin particles is 50 g/g or more; and (4) the amount of residual monomers in the water-absorbent resin is 200 ppm or less. | 2012-05-03 |
20120108422 | Antifungal 1,2,4-triazolyl Derivatives - The present invention relates to novel triazole compounds of the formulae I and II as defined below which carry a sulfur substituent, to agricultural compositions containing them, to their use as fungicides and to intermediate compounds used in the method of producing them. | 2012-05-03 |
20120108423 | Novel Heterocyclic Alkanol Derivatives - The present invention relates to novel heterocyclic alkanol derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators. | 2012-05-03 |
20120108424 | Novel complex for use in stabilizing herbicidal compositions and merthods for synthesizing and using the same - The present invention is directed to the discovery, isolation, identification and methods of synthesis of a novel chemical complex that can be used to stabilize mixtures of different chemical compounds, and in particular mixtures of different herbicidal compounds. | 2012-05-03 |
20120108425 | BIOSYNTHESIS OF GOLD AND SILVER NANOPARTICLES FOR STABILITY AND EXTENDED SHELF-LIFE OF ANTAGONISTIC ACTIVITIES - The use of microbial nanoparticles to stabilize antifungal activity is described. The preferred silver and gold nanoparticles are formed from various categories of microbes like bacteria, fungi and actinomycetes. The silver and gold nanoparticles synthesized from microbes, which can efficiently work as biocontrol/biofertilizer agent in field. The stabilized antagonistic activities of the microbes can be used for many other purposes with respect to the microbe selected for nanoparticle synthesis. Here the selected microbes were an indigenous organisms isolated from the tea fields that can control various diseases, individually and in combination with other microbe as biofertilizer. | 2012-05-03 |
20120108426 | Saline water acidification treatment method - A method for acidifying saline waters for raising plants, comprising injecting sulfur dioxide to form a sufficient amount of sulfurous acid treated saline waters until these buffered acidified waters condition the surface membranes of plant roots to selectively take in water and ions needed for metabolism, while filtering others out to enable the plant to withstand and live in a high salt aqueous environment. | 2012-05-03 |
20120108427 | AQUEOUS HERBICIDE CONCENTRATE - Stable aqueous herbicide concentrate composition containing potassium, ammonium or isopropylamine salts of glyphosate and anionic esters of alkyl polyglycosides containing a salified sulfonic acid group. | 2012-05-03 |
20120108428 | SYNERGISTIC HERBICIDAL COMPOSITION CONTAINING FLUROXYPYR AND QUINCLORAC - An herbicidal synergistic mixture of fluroxypyr and quinclorac provides improved post-emergence weed control in rice, cereal and grain crops, pastures, rangelands, IVM and turf. | 2012-05-03 |
20120108429 | SAFENED AND EFFICACIOUS WEED CONTROL PARTICLE - A weed control particle is provided that includes a delivery granule having a surface and a core. A dicarboximide herbicide is adhered to the surface, mixed into the core of the granule, or both. A dinitroaniline herbicide is adhered to the surface, mixed into the core of the granule, or both. A process of weed control includes distributing such particles or two separate types of particles that each have one of the two types of herbicides to a plot around a desired plant. The weed control particles are distributed at a density such that said dicarboximide herbicide is present at between 20% and 80% of full rate for the dicarboximide herbicide and the dinitroaniline is present at between 20% and 70% of full rate for the dinitroaniline herbicide to provide weed control around the desired plant. | 2012-05-03 |
20120108430 | SYNERGISTIC HERBICIDAL COMPOSITION CONTAINING PENOXSULAM AND ORYZALIN - An herbicidal synergistic composition containing (a) penoxsulam and (b) oryzalin provides improved post-emergence herbicidal weed control in tree and vine crops, turf, sugar cane, range and pasture, parks and alleyways, and IVM. | 2012-05-03 |
20120108431 | PLANT GROWTH REGULATOR ADDITIVE - The present invention relates to a method and composition for improving the efficacy of a plant growth regulator by the use of, particularly but not exclusively, anthranilic acid in combination with an additional agrochemically acceptable additive. | 2012-05-03 |
20120108432 | Cocoalkylpolyamine Alkoxylates as Agents for High Strength Herbicide Compositions - Embodiments of the present invention disclose an agricultural composition having an agrochemical active ingredient and at least one cocoalkylpolyamine alkoxylate agent. | 2012-05-03 |
20120108433 | SUPERCONDUCTING MAGNET COIL SUPPORT WITH COOLING AND METHOD FOR COIL-COOLING - A superconducting magnet coil support with cooling and a method for coil cooling are provided. One superconducting coil support arrangement includes a superconducting coil and at least one support beam supporting the superconducting coil and defining a tank for storing a cooling fluid therein. The superconducting coil support arrangement further includes a plurality of cooling tubes coupled to the superconducting coil and connected to the at least one support beam, wherein the plurality of cooling tubes are configured to transfer the cooling fluid therethrough. | 2012-05-03 |
20120108434 | HYBRID SUPERCONDUCTING-MAGNETIC MEMORY CELL AND ARRAY - In one embodiment, the invention is a hybrid superconducting-magnetic memory cell and array. One embodiment of a memory cell includes a magnetoresistive element and at least one superconducting element wired in parallel with the magnetoresistive element. In a further embodiment, memory cells of the disclosed configuration are arranged to form a memory array. | 2012-05-03 |
20120108435 | JOINT OF SUPERCONDUCTING WIRES AND METHOD FOR JOINING SUPERCONDUCTING WIRES - Provided is a superconducting apparatus, including a joint of superconducting wires having high electric conduction characteristics and a superconducting magnet or the like. The superconducting joint comprises a plurality of superconducting wires and a sinter which integrates the plurality of superconducting wires. Herein, at least any one of the superconducting wires is a MgB | 2012-05-03 |
20120108436 | SUBSTRATE, METHOD OF PRODUCING SUBSTRATE, SUPERCONDUCTING WIRE, AND METHOD OF PRODUCING SUPERCONDUCTING WIRE - A substrate of the present invention includes a copper layer, an alloy layer containing copper and nickel, formed on the copper layer, a nickel layer formed on the alloy layer, and an intermediate layer formed on the nickel layer. The concentration of nickel in the alloy layer at the interface between the alloy layer and the nickel layer is greater than the concentration of nickel in the alloy layer at the interface between the alloy layer and the copper layer. According to the present invention, there can be provided a substrate that allows the AC loss of a superconducting wire to be reduced, a method of producing a substrate, a superconducting wire, and a method of producing a superconducting wire. | 2012-05-03 |
20120108437 | Precursor for Nb3Sn superconductor wire, superconductor wire using the same and method for manufacturing Nb3Sn superconductor wire - A precursor for a Nb | 2012-05-03 |
20120108438 | SUPERCONDUCTORS AND METHODS OF MANUFACTURING THE SAME - A method of manufacturing superconductors with critical temperature T | 2012-05-03 |
20120108439 | METHOD OF PRODUCING SUBSTRATE AND SUPERCONDUCTING WIRE - The present invention relates to a method of producing a substrate, including the steps of preparing a substrate having a nickel layer formed on a copper layer through plating, subjecting the nickel layer to thermal treatment at 800-1000° C., and epitaxial-growing an intermediate layer on the nickel layer, after the step of subjecting the nickel layer to thermal treatment. According to the present invention, there can be provided a substrate that allows the orientation and flatness at the surface of a nickel layer to be improved, and a method of producing the substrate. | 2012-05-03 |
20120108440 | REDUCING ADAPTER DIMER FORMATION - Provided herein is a method of reducing adapter dimer formation comprising contacting a sample comprising target nucleic acid sequences with 5′ and 3′ adapters in the presence of one or more hairpin oligonucleotides. Also provided is a method of preparing a library of nucleic acid sequences comprising contacting first adapter oligonucleotides with a sample comprising target nucleic acid sequences under conditions to form first ligation products, contacting the sample with one or more hairpin oligonucleotides that binds to the first adapter oligonucleotides, and contacting the sample with second adapter oligonucleotides under conditions to bind to the first ligation products and form second ligation products, wherein the second ligation products form the library of nucleic acid sequences. | 2012-05-03 |
20120108441 | POLYMORPHISMS IN ANGIOGENESIS PATHWAY GENES ASSOCIATED WITH TUMOR RECURRENCE IN SURGERY TREATED CANCER PATIENTS - This invention provides compositions and methods for determining the likely tumor recurrence of cancer patients after surgical resection. Said methods are based on determining the patient's genotype for the polymorphisms PAR-1-506 ins/del C and/or EGF+61A>G. | 2012-05-03 |
20120108442 | METHOD FOR THE IDENTIFICATION OF THE CLONAL SOURCE OF A RESTRICTION FRAGMENT - The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising (sample-specific) identifiers are ligated. The adapter-ligated restriction fragments may be selectively amplified with adaptor compatible primers carrying selective nucleotides at their 3′ end. The amplified adapter-ligated restriction fragments are, at least partly, sequenced using high throughput sequencing methods and the sequence parts of the restriction fragments together with the sample-specific identifiers serve as molecular markers. | 2012-05-03 |
20120108443 | Dual polarity analysis of nucleic acids - This invention provides methods for characterizing the amounts of nucleic acids, including plus/minus determinations, the use of different constructs, the use of a library and a reference library. Expression may also be compared in two or more samples using the methods of this invention. Also provided are heterophasic arrays comprising labeled positive copies of nucleic acids hybridized to the array and labeled negative copies of nucleic acids hybridized to the array, in which the labeled positive copies are separately quantifiable from the labeled negative copies. | 2012-05-03 |
20120108444 | COMPOSITIONS AND METHODS FOR DETECTING PREDISPOSITION TO A SUBSTANCE USE DISORDER - The present invention provides screening kits, compositions, and diagnostic methods for determining whether a subject has a predisposition to, or likelihood of having, a substance use disorder by determining a nucleic acid methylation profile from a biological sample from the subject, wherein a given profile indicates that the subject has a predisposition to a substance use disorder. | 2012-05-03 |
20120108445 | VEGF AND VEGFR1 GENE EXPRESSION USEFUL FOR CANCER PROGNOSIS - The invention provides compositions and methods for determining the likelihood of tumor recurrence of adjuvant cancer patients following surgical resection. | 2012-05-03 |
20120108446 | 4-miRNA SIGNATURE FOR PREDICTING CLEAR CELL RENAL CELL CARCINOMA METASTASIS AND PROGNOSIS - An miRNA expression signature comprising a set of one or more miRNAs associated with metastatic cancer is provided. In one embodiment, the expression signature is selected from the group consisting of miR-10b, miR-139-5p, miR-130b and miR-199b-5p. In some aspects, miR-199b-5p and miR-130b are overexpressed in metastatic cancer; and miR-10b and miR-139-5p are downregulated in metastatic cancer. Such an expression signature may be used in methods for predicting metastasis, risk for developing metastasis or a prognosis in a cancer. In another embodiment, a method for establishing such a cancer miRNA expression signature is provided. | 2012-05-03 |
20120108447 | METHODS OF PREDICTING CLINICAL OUTCOME IN MALIGNANT MELANOMA - Malignant melanoma is the most aggressive type of skin cancer and currently accounts for more than 160.000 new cancer cases worldwide every year. Incidence of malignant melanoma is rapidly increasing—with a doubling rate of 10-20 years and a death rate of 11%. The inventors of the present application found genes that predict overall survival of patients with malignant melanoma and that contain prognostic information not comprised in the conventional histopathological and clinical criteria. Accordingly, the present invention relates to the field of oncology, more particularly to methods of predicting clinical outcome in malignant melanoma as defined in the claims. | 2012-05-03 |
20120108448 | SYSTEM AND METHOD FOR CURATING MASS SPECTRAL LIBRARIES - Systems and method for curation of mass spectral libraries. In general, the systems and methods provided herein (a) obtain an experimentally derived mass spectrum of a compound of interest; (b) identify a peak in the mass spectrum that represent an experimental m/z value for an ion fragment of the compound of interest; (c) remove from the mass spectrum any peak that does not correspond to the compound of interest; and (d) replace the experimental m/z value for the peak identified in step (b) with a calculated theoretical m/z value for the ion fragment. | 2012-05-03 |
20120108449 | CRYSTAL STRUCTURE OF ISOGLUTAMINYL CYCLASE - A crystal comprising human isoglutaminyl cyclase having a characterised space group of P1211 and unit cell dimensions of +/−5% of a=126.51 Å, b=109.68 Å, c=159.53 Å, α=90.0°, β=104.9° and γ=90.0°. | 2012-05-03 |
20120108450 | Receptors Useful for Gas Phase Chemical Sensing - The invention provides for a receptor, capable of binding to a target molecule, linked to a hygroscopic polymer or hydrogel; and the use of this receptor in a device for detecting the target molecule in a gaseous and/or liquid phase. The invention also provides for a method for detecting the presence of a target molecule in the gas phase using the device. In particular, the receptor can be a peptide capable of binding a 2,4,6-trinitrotoluene (TNT) or 2,4-dinitrotoluene (DNT). | 2012-05-03 |
20120108451 | METHODS AND APPARATUS FOR NANOPARTICLE-ASSISTED NUCLEIC ACID HYBRIDIZATION AND MICROARRAY ANALYSIS - The invention provides nucleic acid hybridization methods for detecting target nucleic acid sequences wherein complexes comprising nanoparticles non-covalently associated with single-stranded tartlet nucleic acid molecules are incubated with immobilized probe nucleic acid molecules. Because the nanoparticles function as competitors in the hybridization reaction between the target nucleic acid molecules and the probe nucleic acid molecules. The methods provide a high degree of discrimination between a perfectly matched target sequence and a sequence having at least a single-base-pair mismatch, even when the hybridization reaction is performed at room temperature. The invention also provides microarray methods and apparatus which incorporate the nanoparticle-assisted hybridization methods. | 2012-05-03 |
20120108452 | Semi-Invasive Method for Characterizing Lung Injury - Described and disclosed are methods for determining, predicting, diagnosing, treating, and monitoring lung diseases, including bronchiolitis obliterans syndrome and acute cellular rejection in a lung transplant recipient by measuring chemokine levels in bronchoalveolar lavage (BAL) samples. The chemokine CXCL10 is measured in combination with at least one analyte selected from the group consisting of IL1RA, CXCL11, MCP-1, CXCL9, RANTES, IL-13, IL-17, IL-22, fractalkine, and eotaxin; and/or biomarkers. The present teachings also relate to methods, treatment decisions and kits for detecting and monitoring onset of lung transplant rejection in advance of clinically recognized symptoms. | 2012-05-03 |
20120108453 | MOLECULAR MARKERS IN PROSTATE CANCER - The present invention relates to methods for diagnosing prostate cancer and especially diagnosing LG, i.e., individuals with good prognosis; HG, i.e., individuals with poor prognosis of primary tumour; PrCa Met, i.e., individuals with poor prognosis and metastasis; and CRPC, i.e., individuals with poor prognosis suffering from aggressive localized disease. Specifically, the present invention relates to method for establishing the presence, or absence, of prostate cancer in a human individual comprising: a) determining the expression of one or more genes chosen from the group consisting of RRM2, HOXC6, TGM4, RORB, HOXDlO, SFRP2, and SNAI2 in a sample originating from said human individual; b) establishing up, or down, regulation of expression of said one or more genes as compared to expression of said respective one or more genes in a sample originating from said human individual not comprising prostate tumour cells or prostate tumour tissue, or from an individual not suffering from prostate cancer; and c) establishing the presence, or absence, of prostate cancer based on the established up- or down regulation of said one or more genes. | 2012-05-03 |
20120108454 | METHOD, MICROREACTOR AND APPARATUS FOR CARRYING OUT REAL-TIME NUCLEIC ACID AMPLIFICATION - A method for carrying out nucleic acid amplification, includes providing a reaction chamber ( | 2012-05-03 |
20120108455 | Methods for assessing and identifying or evolving conditionally active therapeutic proteins - Methods for evolving or selecting or producing therapeutic proteins that exhibit reduced adverse side-effects and the resulting proteins are provided. For example, provided herein is an in vitro assay to identify conditionally active therapeutic proteins that exhibit better activity within one in vivo environment compared to another in vivo environment. The methods include the steps of a) testing the activity of a protein under conditions in which normal or increased activity is desired; b) testing the activity of the protein under conditions in which reduced activity compared to normal is desired; and c) comparing the activity in a) with b) and selecting/identifying a protein that has greater activity in a) compared to b). The selected/identified protein is a conditionally active protein. | 2012-05-03 |
20120108456 | DEVICE SIMILAR TO AN ELECTROMECHANICAL CAMERA AND METHOD FOR THE PRODUCTION AND USE OF THE DEVICE - A device for detecting chemical or biochemical substances in fluids includes a first carrier having a sensor array with a plurality of electrochemical sensors. A second carrier includes a porous layer having at least one functional region, in which specifically binding capturing molecules are immobilized. The at least one functional region is arranged directly adjacent to at least one non-functionalized region. Assigned to the at least one functional region and the at least one non-functionalized region are several sensors of the sensor array, for use as an electrochemical camera. | 2012-05-03 |
20120108457 | MIR-211 EXPRESSION AND RELATED PATHWAYS IN HUMAN MELANOMA - Provided herein are methods for the diagnosis of human melanoma by assessing MITF, miR-211, TRPM1, and/or KCNMA1. Methods for treating melanoma are also provided. | 2012-05-03 |
20120108458 | METHOD OF SYNTHESIZING SINGLE-STRANDED CDNA, METHOD OF PREPARING MICROARRAY SAMPLE, AND METHOD OF DETECTING NUCLEIC ACID - In order to provide a method of amplifying nucleic acid which can produce a nearly constant amount of amplified products despite the amount of RNA to be used as a template, the primer is used at a final concentration of 500 pM to 500 nM in a reaction which synthesizes a single-stranded cDNA using RNA extracted from a biological sample as a template and using a primer with oligo dT and a promoter sequence. | 2012-05-03 |
20120108459 | METHODS AND DEVICES FOR MOLECULAR ASSOCIATION AND IMAGING - The present invention is directed to devices and methods for molecular association, particularly to devices and methods for hybridization of nucleic acids utilizing temperature gradients and imaging thereof. In one aspect, a molecular hybridization system generally includes a substrate having a plurality of molecular probes attached thereto, the plurality of probes being generally present in multiple copies arranged in localized formations on the surface of the substrate. The molecular hybridization system further generally includes a chamber that encloses the plurality of molecular probes such that a fluid containing sample may be applied and kept in contact with the substrate having the probes thereon. The molecular hybridization system also includes a temperature affecting system that generally produces at least one desired temperature on the surface of the substrate and in the adjacent fluid within the chamber. | 2012-05-03 |
20120108460 | NON-INVASIVE FETAL GENETIC SCREENING BY SEQUENCING ANALYSIS - The invention provides a non-invasive technique for the differential detection of multiple genotypes and/or mutations for a plurality of target genes in a biological sample containing genetic material from different genomic sources. Methods are conducted using multiplex amplification of a plurality of target sequences from the biological sample, and sequencing is used to detect and enumerate genetic mutations and chromosomal abnormalities at the single nucleotide level. | 2012-05-03 |
20120108461 | HIGH-THROUGHPUT SLIDE PROCESSING APPARATUS - An assay device and method of use thereof includes a sample tray comprising a plurality of sample wells having a first volume, and a slide tray comprising a slide, and a liquid dispenser. The slide comprises a plurality of reaction sites on a bottom surface of the slide. The liquid dispenser is configured to dispense a plurality of liquid samples into the sample wells. The sample wells are configured to hold the liquid samples. Each of the liquid samples has a second volume such that the second volume exceeds the first volume and each of the liquid sample sits within and above one of the sample wells. The slide tray and the sample tray are configured such that the slide tray can be placed onto the sample tray, at least one of the reaction sites can be positioned directly above at least one of the sample wells containing a liquid sample, and the liquid sample can be drawn onto the reaction site upon the liquid sample contacting the bottom surface of the slide. | 2012-05-03 |
20120108462 | MIRNA FINGERPRINT IN THE DIAGNOSIS OF LUNG CANCER - The present invention provides novel methods for diagnosing diseases based on the determination of specific miRNAs that have altered expression levels in disease states compared to healthy controls. | 2012-05-03 |
20120108463 | COMPOSITIONS AND METHODS FOR MEMBRANE PROTEIN DETERGENT STABILITY SCREEN - The invention provides methods to assess protein stability and to obtain sizing information. In one aspect, the screen comprises a 94 detergent panel and a series of MWCO filtered microplates. A protein of interest is bound to an affinity matrix and aliquoted into a 96-well microplate. Wells containing the immobilized protein are washed in the new detergent and then eluted in the new detergent into a collection plate. Protein not stable in the new detergent is precipitated on the resin and not present in the elutions. Half of the elution is passed through a high (i.e., 300 kDa) MWCO microplate and the other half through a low (i.e., 100 kDa) MWCO microplate. Elutions from the microplates are spotted on a nitrocellulose membrane, visualized by Western analysis (or by some other method), and quantified. The high MWCO provides stability readout and the ratio of low/high kDa provides sizing information. | 2012-05-03 |
20120108464 | TEST SYSTEMS, METHODS AND USES INVOLVING AS160 PROTEIN - The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system comprising AKT substrate 160 kDa-protein (AS160-protein) with a test substance, and identifying a test substance as a substance altering glucose uptake of a cell by detecting a signal indicative for altered glucose uptake of a cell; a test system comprising a gene coding for the AKT substrate 160 kDa-protein (AS160-protein) and an inducible promoter providing for controllable expression of the gene; the use of the test system for the identification of a substance improving glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell; and the use of AS 160-protein in a model for type 2 diabetes. | 2012-05-03 |
20120108465 | FIBER ARRAY SENSOR - A sensor array is provided including a plurality of fibers being woven to form 3-D periodic fiber structures. A selective number of the fibers include gaseous sensing materials to detect selective gases. A plurality of spacing elements provides adequate spacing between successively arranged nano-fibers. The nano-fibers and spacing elements are arranged to form a 3-D scaffolding structure for detecting specific or combinations of gaseous analytes. | 2012-05-03 |
20120108466 | IMMUNOGLOBULIN LIBRARIES - Methods and compositions for the screening and isolation of ligand-binding polypeptides, such as antibodies. In some aspects, methods of the invention enable the isolation of intact soluble antibodies comprising a constant domain. Screening methods that employ genetic packages such as bacteria and bacteriophages enable high through-put identification of ligand binding molecules. | 2012-05-03 |
20120108467 | Nucleic Acid Analysis Using Sequence Tokens - The present invention provides methods and compositions for tagging nucleic acid sequence fragments, e.g., a set of nucleic acid sequence fragments from a single genome, with one or more unique members of a collection of oligonucleotide tags, or sequence tokens, which, in turn, can be identified using a variety of readout platforms. As a general rule, a given sequence token is used once and only once in any tag sequence. In addition, the present invention also provides methods for using the sequence tokens to efficiently determine variations in nucleotide sequences in the associated nucleic acid sequence fragments. | 2012-05-03 |
20120108468 | Cell-based arrays, methods of making, and methods of using - Embodiments of the present disclosure provide for arrays, systems, and methods for the analyzing cells, methods of making arrays, and the like. | 2012-05-03 |
20120108469 | APPARATUS FOR COMBINATORIAL SYNTHESIS - Apparatus and methods are described for split synthesis combinatorial chemistry that provides candidate libraries where an even distribution of theoretical products is obtainable through even mixing during the pooling step, followed by controlled redistribution of the mixed pooled products from the prior addition step into separate synthesis columns, one for each different specie of subunit to be added. | 2012-05-03 |
20120108470 | MICROFLUIDIC MAGNETOPHORETIC DEVICE AND METHODS FOR USING THE SAME - A microfluidic device may employ one or more sorting stations for separating target species from other species in a sample. The separation is driven by magnetophoresis. A sorting station generally includes separate buffer and sample streams. A magnetic field gradient applied to the sorting station deflects the flow path of magnetic particles (which selectively label the target species) from a sample stream into a buffer stream. The buffer stream leaving the sorting station is used to detect or further process purified target species labeled with the magnetic particles. | 2012-05-03 |
20120108471 | Volcanic Ash-Based Drilling Mud to Overcome Drilling Challenges - Drilling mud compositions and related methods are provided as embodiments of the present invention. The drilling mud compositions are water-based and contain volcanic ash. The compositions and methods of the present invention provide improved properties relative to tolerance of high salt content, cement, lime, and temperatures. | 2012-05-03 |
20120108472 | Thermoplastic Cellulosic Fiber Blends as Lost Circulation Materials - A method is disclosed for reducing lost circulation in drilling wells, employing composite materials as lost circulation materials. The composites comprise a thermoplastic polymer and cellulosic fibers. Optionally the composites may include other components such as calcium carbonate, clay, oil and other blending agents. | 2012-05-03 |
20120108473 | PROCESS FOR TREATMENT OF PRODUCED WATER OBTAINED FROM AN ENHANCED OIL RECOVERY PROCESS USING POLYMERS - A process for treatment of produced water obtained from an enhanced oil recovery process from a reservoir, said water containing at least one water-soluble polymer, wherein:
| 2012-05-03 |
20120108474 | LUBRICANT MEMBER AND METHOD OF MANUFACTURING THE SAME - A lubricant member of a preferred embodiment of the invention is formed, into a stick-shaped body longer in a lengthwise direction than in a diametrical direction, of a mixture including at least a polyamide resin as a thermoplastic resin, an ultrahigh molecular weight polyethylene, and lubricant oil. A film made mainly of the polyamide resin is formed in the outer peripheral surface of the lubricant member. At the inner side of the film, fibrous crystals of the polyamide resin and the ultrahigh molecular weight polyethylene extend in the lengthwise direction of the lubricant member, and multiple pores are formed. With this structure, the lubricant member is produced with excellent workability without sacrificing the mechanical strength and the lubricating property. | 2012-05-03 |
20120108475 | METHOD FOR PRODUCING A STABLE BORIC SOLUTION - The invention relates to a method for producing a stable boron solution with lubricating characteristics which is intended to be used preferably as an addition in the form of a concentrate/additive to a liquid, e.g. to a liquid fuel or a lubricant. The invention is achieved by the method steps of using a boron substance of pharmaceutical quality ( | 2012-05-03 |
20120108476 | LUBRICATING OIL COMPOSITIONS - The present invention generally relates to a method for reducing intake valve deposits in a Direct Injection Spark Ignition engine, the method comprising operating the engine with a lubricating oil composition comprising:
| 2012-05-03 |
20120108477 | Natural gas engine lubricating oil compositions - A natural gas engine lubricating oil composition is disclosed which comprises (a) a major amount of an oil of lubricating viscosity, (b) one or more phosphorus-containing anti-wear additives, (c) one or more oil soluble overbased alkaline earth metal-containing detergents; and (d) one or more oil soluble neutral alkali metal-containing detergents, wherein the natural gas engine lubricating oil composition contains no more than about 0.03 weight percent of phosphorus, based on the total weight of the natural gas engine lubricating oil composition. | 2012-05-03 |
20120108478 | LUBRICANT COMPOSITION SUITABLE FOR ENGINES FUELED BY ALTERNATE FUELS - A lubricant composition suitable for use in engines fueled by gasoline or biorenewable fuels or both, comprising an oil of lubricating viscosity and a dispersant system is disclosed herein. Also disclosed is an emulsion composition comprising a biorenewable fuel, an oil of lubricant viscosity, and a dispersant system. A method of reducing aqueous separation in an emulsion composition is also disclosed. | 2012-05-03 |
20120108479 | COMPRESSOR OILS HAVING IMPROVED OXIDATION RESISTANCE - A compressor lubricant composition providing energy savings and exhibiting excellent oxidation stability is provided, as well as a process for preparation of the lubricant composition. The composition comprises: (i) from 68 to 99.999 wt % of an isomerized base oil or blend of isomerized base oils; (ii) 0.001 through 20 wt % of a blend of ashless additives, the ashless additives having a viscosity range at 40° C. of from 50 mm | 2012-05-03 |
20120108480 | LUBRICANT ADDITIVES - Processes are described for producing liquid, biobased lubricant additives containing from 50 to 100% biobased carbon according to ASTM D6866 from heat-bodied oils by transesterification with biobased or petroleum based alcohols and by hydrotreatment of at least the resulting diesters, triesters and polyesters. | 2012-05-03 |
20120108481 | LUBRICATING COMPOSITION - The present invention provides a lubricating composition comprising: a base oil; and a viscosity index improver containing poly(meth)acrylate having hydroxyl groups in the structure and having a hydroxyl value of from 22 to 37. | 2012-05-03 |
20120108482 | POLYAKYLENE GLYCOLS USEFUL AS LUBRICANT ADDITIVES FOR GROUPS I-IV HYDROCARBON OILS - Certain polyalkylene glycols, useful as lubricant additives, are soluble with all four types of hydrocarbon base oils (Groups I-IV) at a wide variety of ratios of oil to polyalkylene glycol and under a variety of conditions. These polyalkylene glycols are prepared by reacting a C8-C20 alcohol and a mixed butylene oxide/propylene oxide feed, wherein the ratio of butylene oxide to propylene oxide ranges from 3:1 to 1:1. The invention provides a means of providing desirable lubricant compositions which may pose fewer environmental problems. | 2012-05-03 |
20120108483 | COLOR INDICATION OF EFFECTIVENESS OF IMMISCIBLE LIQUID SUSPENSION - A two-part liquid product, the first of which comprises a first solvent and a first dissolved dye; and the second of which comprises a second solvent and a second dissolved dye. The two solvents are immiscible. The first dye is insoluble in the second solvent, and the second dye is insoluble in the first solvent. Each dye is a different color than the other. Initially, when placed in a single container, the two parts form two separate different colored layers that do not mix. Shaking the container produces a temporary micro-emulsion. The emulsion has a new color representing the combination of the colors of the two component layers. This combination color indicates to the user that an emulsion exists and that the product is effective. The component materials are selected so as to produce a stable emulsion for between five to twenty minutes before separation. | 2012-05-03 |
20120108484 | CLEANING AGENT CONTAINING CARBAMIDE AND/OR AT LEAST A DERIVATIVE THEREOF - The invention relates to the use of an agent that contains 5 to 99.9% by weight of carbamide and/or at least a derivative thereof, as a cleaning agent e.g. for closed systems, in particular as a dishwasher detergent, as a laundry detergent for washing machines, as an agent for cleaning, sanitizing and/or disinfecting for equipment in the food processing industry and for medical equipment, the use as a hand dishwashing detergent or sanitary cleaner or as a hand cleaner. | 2012-05-03 |
20120108485 | MULTI-AGENT TYPE CLEANING KIT FOR SEMICONDUCTOR SUBSTRATES, CLEANING METHOD USING THE SAME AND METHOD OF PRODUCING SEMICONDUCTOR ELEMENT - A multi-agent type cleaning kit for applying to semiconductor substrates, which contains a foaming agent having an alkylene carbonate and a carbonic acid salt, a foaming aid having an acidic compound, and an oxidizing agent; at least the foaming agent is mixed with the foaming aid upon using for the cleaning of a semiconductor substrate, in combination with the oxidizing agent. | 2012-05-03 |
20120108486 | COMPOSITIONS AND METHODS FOR REMOVING ORGANIC SUBSTANCES - Compositions and methods useful for the removal of organic substances from substrates, for example, electronic device substrates such as microelectronic wafers or flat panel displays, are provided. A method is presented which applies a minimum volume of the composition as a coating to the inorganic substrate whereby sufficient heat is added and immediately rinsed with water to achieve complete removal. These compositions and methods are particularly suitable for removing and completely dissolving photoresists of the positive and negative varieties as well as thermoset polymers from electronic devices. | 2012-05-03 |
20120108487 | Unit Dose Detergent Compositions And Methods Of Production And Use Thereof - The present invention provides unit dose detergent products, such as those in the form of compositions comprising: a water-soluble single-chamber container, such as a pouch; and a cleaning system comprising at least one detersive surfactant, and optionally one or more additional components. The invention also provides methods of production of such compositions, and methods use of such compositions in processes for cleaning dishware and/or fabrics, including garments, by introducing one or more of the unit dose products of the invention into an automatic washing machine suitable for washing dishware or laundry, whereby the cleaning system is released such that it comes into contact with a soiled article (e.g., dishware or fabrics) under conditions favoring the removal of one or more soils from the article. | 2012-05-03 |
20120108488 | Cleaning And/Or Treatment Compositions - This invention relates to compositions comprising certain fungal serine proteases and processes for making and using such compositions including the use of such compositions to clean and/or treat a situs. | 2012-05-03 |
20120108489 | ACID CLEANING AND CORROSION INHIBITING COMPOSITIONS COMPRISING GLUCONIC ACID - A biodegradable acid cleaning composition for cleaning stainless steel, and other surfaces is disclosed. The composition comprises urea sulfate in combination with gluconic acid which serves as a corrosion inhibitor. The composition retains the cleaning and corrosion prevention properties of similar phosphoric acid solutions but is safe for the environment and is less expensive to produce. Applicants have surprisingly found that the traditionally alkaline corrosion inhibitor, gluconic acid, can work effectively in an acidic cleaning composition. | 2012-05-03 |
20120108490 | CLEANING COMPOSITION THAT PROVIDES RESIDUAL BENEFITS - A composition for use on a hard surface. The composition has: (i) at least 7.5 wt. % of at least one surfactant selected; (ii) a transport rate factor of less than about 55 seconds; and (iii) an adhesion time of greater than about 8 hours. | 2012-05-03 |
20120108491 | Particles Comprising Active Compounds - The present invention relates to a particle comprising an enzyme and a polymer wherein the enzyme and polymer is present as a mixture in the particle and the polymer is substantially soluble in an aqueous solution having an ionic strength of 0 mol/kg and insoluble in an aqueous solution having an ionic strength of more than 1 mol/kg according to method 1 of the invention. | 2012-05-03 |
20120108492 | LIGAND-SPECIFIC NON-ANTIBODY COMPOUNDS THAT INHIBIT CR2 ACTIVATION AND METHODS OF USE THEREOF - The present invention describes a novel non-antibody ligand-specific compound that selectively binds to a complement receptor type 2 (CR2) protein, a ligand thereof, or both, wherein the compound competitively inhibits CR2 ligand's binding to a CR2 protein in a standard assay. The present invention also describes compositions and methods of use thereof. | 2012-05-03 |
20120108493 | Polypeptide Fragments Comprising Endonuclease Activity and Their Use - The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting. This invention also relates to compounds and pharmaceutical compositions comprising the identified compounds for the treatment of disease conditions due to viral infections caused by viruses of the Orthomyxoviridae family. | 2012-05-03 |
20120108494 | INHIBITORS OF INTRACELLULAR UROKINASE PLASMINOGEN ACTIVATOR AND METHODS OF USE THEREOF - The present invention provides compositions comprising amiloride amino acid and peptide conjugates. Efficient methods are also provided for administering the compositions for treating cancer and for delivering an amiloride conjugate into cancer cells in a subject in need thereof. | 2012-05-03 |
20120108495 | Method of Inhibiting Smooth Muscle Cell Proliferation by Using Reconstituted HDL - A method of inhibiting smooth muscle cell proliferation comprising administering to a subject a pharmaceutical composition including reconstituted HDL as an active ingredient. | 2012-05-03 |
20120108496 | SHORT-CHAIN PEPTIDES AS PARATHYROID HORMONE (PTH) RECEPTOR AGONIST - The present invention provides novel short-chain peptides, which primarily act as parathyroid hormone (PTH/PTH-1) receptor agonist. These short-chain peptides exhibit increased stability to proteolytic cleavage. Most of short-chain peptides were found to be stable in rat plasma up to 24 hours (in vitro), showed increased stability against GIT enzymes such as pepsin and acidic stomach pH and also against liver microsomes (in vitro). Due to increased metabolic stability, other than parenteral route of administration, some of the short-chain peptides can also be delivered by oral routes of administration, for the treatment/prevention of hypoparathyroidism and diseases characterized by bone mass reduction, such as osteoporosis, postmenopausal osteoporosis and for stimulating bone repair. A-Z | 2012-05-03 |
20120108497 | COMPOSITIONS FOR CONFERRING TOLERANCE TO VIRAL DISEASE IN SOCIAL INSECTS, AND THE USE THEREOF - Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed. | 2012-05-03 |
20120108498 | STRUCTURAL AND MECHANISTIC BASIS FOR NOVEL COMPOUND BIOSYNTHESIS USING THE 4-ELECTRON HEXOSE OXIDASE - A novel pharmaceutical composition comprising a compound of formula (I) is disclosed. The novel compound can include a pharmaceutically acceptable carrier. The invention further comprises methods for making compounds of formula (I) using Dbv29, and to the use of compound of formula (I) to treat bacterial infections. | 2012-05-03 |
20120108499 | PEPTOID COMPOUNDS - The invention relates to new peptoid compounds of formula (I), as well as their use in the treatment of bacterial infections, such as those caused by vancomycin resistant microorganisms, and to compositions thereof. | 2012-05-03 |
20120108500 | Compositions and Methods for Modulating Immunodeficiency Virus Transcription - The present disclosure provides methods of modulating immunodeficiency virus transcription, involving modulating enzymatic activity and/or levels of a lysine-specific demethylase-1 (LSD1) polypeptide and/or LSD1-mediated demethylation of methylated Tat. The present disclosure also provides method of identifying agents that modulate LSD1-mediated demethylation of a human immunodeficiency virus (HIV) Tat polypeptide. | 2012-05-03 |
20120108501 | Protease Inhibitors - The invention relates to (among other things) protease inhibitors containing both a water-soluble, non-peptidic oligomer and a lipophilic moiety-containing residue. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over protease inhibitor compounds lacking the water-soluble, non-peptidic oligomer and a lipophilic moiety-containing residue. | 2012-05-03 |
20120108502 | NOVEL ANTI-PARASITIC COMPOUNDS - A novel structural class of highly N-methylated linear lipopeptide compounds useful for the treatment of parasitic disease. | 2012-05-03 |
20120108503 | METHODS FOR TREATING TYPE I DIABETES WITH LEPTIN AND LEPTIN AGONISTS - The present invention provides for methods of treating type I diabetes by inducing hyperleptinemia in subjects afflicted with type I diabetes. These methods can achieve normoglycemia and suppress hypergluconemia, and alleviate conditions associated with such, even in the absence of or at extremely low levels of adjunct insulin therapy, and without any appreciable increase in insulinogenesis. | 2012-05-03 |
20120108504 | LEPTIN AGONIST AND METHODS OF USE - Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, type II diabetes, appetite control after bariatric surgery, insulin resistance, lipodystrophy and hypothalamic amenorrhea, obesity-related infertility, among other diseases and conditions related to leptin deficiency and/or leptin resistance. | 2012-05-03 |
20120108505 | THIOPHENES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE - The present invention relates to compounds of the general formula (I): wherein R | 2012-05-03 |
20120108506 | Agent For Suppressing Postprandial Elevation Of Blood Insulin Concentration - An agent for suppressing postprandial elevation of blood insulin concentration, comprising a polyglutamic acid as an active ingredient. | 2012-05-03 |
20120108507 | Methods for In Vivo Cell Reprogramming - The present disclosure provides a new technology platform that converts one type of cells (substrate cells) to another type of cells (product cells). | 2012-05-03 |
20120108508 | METHOD FOR PROMOTING SECRETION OF GLUCAGON-LIKE PEPTIDE-1 BY ADMINISTERING K-CASEIN - The invention relates to a GLP-1 secretagogue and an inhibitor of postprandial rise in blood glucose, containing κ-casein as an active ingredient, and a food or drink for promoting GLP-1 secretion and an inhibitory food or drink of postprandial rise in blood glucose, containing a milk-derived casein protein wherein κ-casein accounts for 60% by mass or more of the milk-derived casein. | 2012-05-03 |
20120108509 | ARTIFICIAL SCAB FOR USE IN AN AIRWAY - Body tissue and structures in an airway may be treated with an artificial scab comprising an inhomogeneous, uncohesive, solid sheet-like body comprising a granular mixture of chitosan and polysaccharide particles. The artificial scab breaks apart into smaller pieces if peeled away from the surgical site or wound, thus reducing the risk of airway occlusion. | 2012-05-03 |
20120108510 | METHODS OF IMPROVING BEHAVIORAL THERAPIES - This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or reducing the severity of psychotherapeutic or social disorders such as autism, and in particular the use of these compounds as an adjunct to psychotherapeutic counseling or behavioral therapy. | 2012-05-03 |
20120108511 | PREPARATION OF BIODEGRADABLE POLYESTERS WITH LOW-BURST PROPERTIES BY SUPERCRITICAL FLUID EXTRACTION - The invention provides methods of extracting a biodegradable polyester with a supercritical fluid effective to obtain a purified biodegradable polyester, such as a purified biodegradable poly(lactide-glycolide) (PLG). The supercritical fluid can be carbon dioxide at an elevated pressure, or can be carbon dioxide with one or more cosolvents. Methods for carrying out stepwise purification of the biodegradable polyester at multiple pressures or multiple temperatures, or both, are also provided. When the polyester is PLG, a purified PLG copolymer is obtained having a narrowed molecular weight distribution with respect to the unpurified polyester. The purified PLG copolymer can have a polydispersity index of less than about 1.7, less than about 2% monomers, and less than about 10% oligomers. The purified PLG copolymer can exhibit a reduced initial burst effect when incorporated into a controlled release formulation such as a flowable implant adapted to be injected into body tissues. | 2012-05-03 |
20120108512 | STABLE PHARMACEUTICAL COMPOSITIONS OF PEPTIDE DERIVATIZED USING AN OXIME LINKER - The invention relates to stable pharmaceutical compositions comprising a therapeutic peptide derivatized with a property-modifying group, wherein the property-modifying group is conjugated to the peptide by use of a linker comprising an oxime bond. | 2012-05-03 |
20120108513 | PURIFICATION METHOD FOR DIVALENT CATION BINDING PROTEINS ON ANION EXCHANGE RESIN - The present invention relates to a method for the purification of divalent cation binding proteins with high purity on an anion exchange resin material, to divalent cation binding proteins obtainable by said method, and to a kit comprising means for carrying out said method. | 2012-05-03 |
20120108514 | LONG ACTING ATRIAL NATRIURETIC PEPTIDE (LA-ANP) AND METHODS FOR USE THEREOF - Materials and Methods related to making and using natriuretic polypeptides having a mutation that results in an extended carboxy terminus. | 2012-05-03 |
20120108515 | NOVEL PEPTIDE DERIVATIVES FOR TREATMENT, PREVENTION OR ALLEVIATION OF A CONDITION ASSOCIATED WITH BONE LOSS OR LOW BONE DENSITY OR TO INHIBIT OSTEOCLAST DIFFERENTIATION AND STIMULATION - Novel compounds which may be for treatment, prevention or alleviation of a condition associated with bone loss or low bone density or to inhibit osteoclast differentiation and stimulation, bone resorption, or loosening of a prosthetic device. | 2012-05-03 |
20120108516 | THE USE OF MIDKINE PROTEIN AND THE PROTEIN-CONTAINING MEDICAL DEVICE - The applications and medical devices of Midkine in the field of biotechnology are described in this invention. This invention describes the applications of the protein as follow in (a) or (b) in preparing drugs for promoting cartilage growth or treating cartilage diseases, the protein as a growth factor for promoting chondrocyte proliferation, or medical devices containing this protein: (a) the protein whose amino acid sequence is shown as SEQ ID NO.1; (b) the proteins whose amino acid sequence have at least 60% homology comparing with amino acid sequence described in (a) and have activity for promoting proliferation of chondrocyte. The protein described in this invention promotes proliferation of three types of chondrocytes and is used for preparing drugs for treating cartilage disease. It may provide new therapy for treating cartilage diseases clinically, and new technology for expansion of chondrocytes in vitro for cartilage tissue engineering. | 2012-05-03 |
20120108517 | Agents and methods for denervation - Various agents are described to denerve, modulate, or otherwise affect the renal nerves and other neural tissue. Also, various delivery devices are described to deliver an agent locally to the renal nerves. The delivery devices are positioned in the renal artery and penetrate into the wall of the renal artery to deliver the agent to the renal nerves. The delivery devices may be used to deliver the agent according to longitudinal position, radial position, and depth of the renal nerves relative to the renal artery. In addition, various methods are described to denervate, modulate, or otherwise affect the renal nerves and other neural tissue. | 2012-05-03 |
20120108518 | TREATMENT OF ALLODYNIA, HYPERALGESIA, SPONTANEOUS PAIN AND PHANTOM PAIN - The present invention relates to the use of Meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain. In a preferred embodiment the disorder to be treated is allodynia, and hyperalgesia, more preferably allodynia including thermal and tactile allodynia. | 2012-05-03 |