17th week of 2010 patent applcation highlights part 41 |
Patent application number | Title | Published |
20100104997 | Air Impingement Conveyor Oven - An air impingement conveyor oven incorporating a baking case having an interior space bordered by opposing longitudinal walls, opposing lateral walls, a ceiling, and a floor; an air plenum partitioning the baking case's interior space into an air impingement space and an air return space, the air plenum having at least a first intake port opening at the air return space, the air plenum further having a plurality of air impingement ducts extending into and opening at the air impingement space; a passive flow conduit opening the baking case, the passive flow conduit having an output end positioned at the return air space; a combustible fuel injector and igniter connected operatively to the passive flow conduit; and an air impelling fan mounted operatively within the baking case's interior space for recirculating impingement air from the air impingement space into the air return space, for drawing outside combustion air through the passive flow conduit, and for driving the air through the at least first intake port into the air plenum. | 2010-04-29 |
20100104998 | Dental Splint - A removable splint for treating certain orofacial disorders has a chewing surface and can be worn while the patient is eating. The splint fits over some or all of the maxillary or mandibular teeth. The chewing surface is preferably shaped like the occlusal surfaces of the natural teeth of the patient. The device may be made to look like natural teeth and gums. Preferably, the natural look is achieved by coloring the material of the splint during or after casting and placing denture teeth in the part of the splint that shows when the patient smiles. | 2010-04-29 |
20100104999 | Apparatus, System, and Method for Intra-Oral Distraction - Described herein are various embodiments of a bone distraction osteogenesis system and associated apparatus and methods that overcome at least some shortcomings of the prior art. According to one representative embodiment, a bone distraction system for distracting a portion of bone from a source bone includes a first anchor portion couplable to an anchor bone and a second anchor portion couplable to a distractable bone segment of the source bone. The system includes a distractor coupling the first anchor portion and the second anchor portion. The overall length of the distractor is decreasable to pull the distractable bone segment toward the anchor bone for distracting the bone segment. | 2010-04-29 |
20100105000 | ORTHODONTIC BRACKET - Orthodontic bracket comprising a body ( | 2010-04-29 |
20100105001 | APPARATUS, SYSTEM, AND METHOD FOR MAXILLO-MANDIBULAR FIXATION - Described herein are various embodiments of an apparatus, system, and method for maxillo-mandibular fixation. For example, according to one representative embodiment, an apparatus for maxillo-mandibular fixation includes a plurality of connectors, a fixation belt, and a release. The connectors include one or more anchors configured to attach to bone and a fixation belt attachment. The fixation belt includes a plurality of fasteners each fastener attachable to a fixation belt attachment and a flexible mesh disposed between the plurality of fasteners. The release is disposed on the fixation belt and has an engaged position restricting movement between the plurality of fasteners and a disengaged position allowing movement between the plurality of fasteners. | 2010-04-29 |
20100105002 | DENTAL MODEL, ARTICULATOR AND METHODS FOR PRODUCTION THEREOF - A model of at least a part of a dental structure, an articulator, and methods of manufacturing such devices are provided. The model and the articulator can be used to approximate the natural movements of a jaw of a patient to facilitate preparation of a dental restoration. The model can comprise the dental structure, an interface, and at least one void extending from a reference surface of the interface inwardly toward the void. The articulator can comprise upper and lower portions on which models of upper and lower dental structures can be held. The upper and lower portions of the articulator can be configured to generally maintain a vertical alignment while at least one gap formed between respective first and second alignment components thereof allows horizontal movability of the upper and lower portions relative to each other to test the interfit of the models therebetween. | 2010-04-29 |
20100105003 | DISPOSABLE DEVICE FOR EJECTING A LIQUID OR PASTY PRODUCT - Device for ejecting a liquid or pasty product, comprising a body ( | 2010-04-29 |
20100105004 | ENDODONTIC FILE - An endodontic file ( | 2010-04-29 |
20100105005 | APPARATUS, SYSTEM, AND METHOD FOR IMPLANTING DENTAL PROSTHESIS - Described herein are various embodiments of a dental prosthesis implant system and associated apparatus and methods that overcome at least some shortcomings of the prior art. According to one representative embodiment, a connector for an implant retained prosthesis includes a first portion securable to a prosthesis and a second portion securable to an implant embeddable within a bone under a gingival layer. The first portion includes a first engagement element. The second portion includes a second engagement element that defines an internal cavity. The first engagement element is positionable within the internal cavity. When the second portion is secured to the implant and the first engagement element is positioned within the internal cavity, at least a portion of the internal cavity and first engagement element is within the gingival layer. In one implementation, the first portion is coupleable to the second portion via a snap-fit connection. | 2010-04-29 |
20100105006 | ATTACHMENT SYSTEM FOR ATTACHING A DENTAL SUPERSTRUCTURE TO AN IMPLANT, AN ATTACHMENT DEVICE AND AN ANCHORING ELEMENT - An attachment system for removably securing a dental superstructure to a dental implant is provided. This attachment system has a first part, connected to, or arranged at, said dental superstructure, and a second part, connected to, or arranged at, said dental implant. These parts are removably securable to each other. An attachment device and an anchoring element that may be comprised in such a system are also provided. | 2010-04-29 |
20100105007 | Plate element for the manufacture of a dental prosthesis - The curved plate is used to position and model a malleable material capable of temporarily supporting the incisor and pinless teeth according to positions and orientations that will then be fixed permanently in the prosthesis. The plate has a general U shape, delimited by two parabola-shaped contours: an outer edge and an inner edge, respectively corresponding to the contour of the vestibular walls of the incisor and pinless teeth of the prosthesis to be built. The plate features a flat surface on its lower face, and an appendix defining a visible reference point that must correspond to the position of the interincisive papilla. The distance between the reference point and an average central point of the outer edge indicating a position situated between the more vestibular walls of the upper central incisor teeth, is between 8 and 10 mm. | 2010-04-29 |
20100105008 | Methods For Manufacturing Dental Implant Components - A method of manufacturing a rapid prototype overmold for locating a dental implant analog in a modified stone model for use in creating a tooth prosthesis is provided. An impression of a mouth having a first installation site that has a dental implant and a gingival healing abutment with at least one informational marker installed is taken. A stone model based on the impression is prepared. The model is scanned. A three-dimensional computer model of the installation site on a CAD program using data from the scan is created. The at least one informational marker is determined to gather information about the location of the dental implant. Abutment dimensional information based on the three-dimensional image and the at least one informational marker is developed. Overmold rapid prototype dimensional information based on the three-dimensional image is developed. The overmold rapid prototype adapted to fit over the modified stone model is fabricated. | 2010-04-29 |
20100105009 | System, Method And Apparatus For Tooth Implants - A systematic approach to planning and selection of a dental implant. Models of the patient's dentition, including the gingival and supporting bone structure are analyzed in relation to a model of the dentition that will be replaced by the implant. Based on information collected from a missing tooth (or teeth) model, greater insight can be gained into the functional and aesthetic attributes of the implant best suited for the patient. And from this realization a more informed decision can be made for planning the procedure for installation of the implant for the patient, and selection of the implant, e.g., size, type and orientation of supporting fixture and abutment. | 2010-04-29 |
20100105010 | Methods and systems for producing demonstration and therapeutic models of dentition - In certain embodiments, the present invention relates to methods for producing demonstration models of dentition, which may be used for a variety of purposes, including, for example, installing dental implants in a patient and designing orthodontic devices. According to certain embodiments of the invention, methods for installing dental implants in a patient are provided. The methods generally comprise producing a demonstration model of a patient's teeth and a pilot hole for a dental implant and using the model as,a guide for drilling a pilot hole at the implant site. According to such embodiments, the step of producing the demonstration model comprises (a) capturing a digital image of patient's mouth region using a digital image acquisition system, (b) performing a digital image segmentation of the patient's teeth apart from a set of volumetric data (to produce a segmented image of the teeth), (c) identifying the implant site for the dental implant within the segmented image, (d) deriving the pilot hole and dimensions thereof at the implant site within the segmented image, and (e) manufacturing a real-sized demonstration model of the patient's teeth with the pilot hole disposed therein. The invention provides that a drill sleeve may be secured to the real-sized demonstration model within the pilot hole to produce a transfer tray, which may then be placed in the patient's mouth. According to such embodiments, the drill sleeve may be used as a guide for the pilot drill, such that the implant may thereafter be installed in the patient's mouth. | 2010-04-29 |
20100105011 | System, Method And Apparatus For Tooth Implant Planning And Tooth Implant Kits - Systems and methods support dental implant patient scheduling and treatment process relating to packaging one or more dental appliances as a kit which is readily used by dental professional during surgery, by communicating manufacturing progress information with a doctor over a network and performing patient scheduling and treatment when the dental appliances reach a certain manufacturing progress. A network-based service may also provide a doctor with a treatment solution including a surgical kit derived from patient data. | 2010-04-29 |
20100105012 | MOTION AND ORIENTATION SIMULATOR - The invention relates to a motion and orientation simulator with a cardanic suspension ( | 2010-04-29 |
20100105013 | String dispenser having an adhesive therein - A string dispenser kit is described. The string dispenser kit includes a string dispenser and a peg board. The string dispenser is formed as a string pen having a string storing element, an elongated barrel, and a tip element. The string pen is formed to store string and dispense string through the elongated barrel and from the tip element of the string dispenser. An adhesive substance is contained in the elongated barrel to douse the string. The peg board has a first plate with pegs and a second plate with corresponding holes. The second plate is formed to be positioned over the first plate. Once the string is positioned over the pegs in a desired form and the adhesive substance is dry, the second plate can be removed from the first plate to pull the string from the pegs and maintain the string in the desired form. | 2010-04-29 |
20100105014 | Kit With Integral Sketching Device - A kit for guiding a user is drawing a trace includes a sketching device coupled to a paper tablet. The sketching device comprises a first pattern of raised bumps sized and positioned to form a plurality of intersecting grooves along the surface of the sketching device. | 2010-04-29 |
20100105015 | SYSTEM AND METHOD FOR FACILITATING THE DECODING OR DECIPHERING OF FOREIGN ACCENTS - A system for decoding foreign accents includes a visual display monitor, an audio display device, and a processor. The processor is electrically connected to, and configured for communication with, the visual display monitor and the audio display device. The processor is further configured to exert a measure of control over the visual display monitor and the audio display device to display aural and visual content. The processor is still further configured to train a user of the system to understand the nature of a mispronunciation of a native language word by a foreign language speaker, and to comprehend a response thereto. The processor is yet still further configured to validate the user's understanding and comprehension by allowing the user to determine whether his response to a mispronunciation was accurately performed following an aural display of the mispronunciation through the audio display device. | 2010-04-29 |
20100105016 | Format for presenting a story and method of use - A format for presenting a story includes page stations which contain first and second narratives, the second narrative being written at a higher reading level than the first narrative. Both narratives convey the same thought but do so using different words, phases, concepts, and/or sentence structure. The page also contains an image which depicts the contents of the two narratives. The image connects the two narratives, and can therefore be used as a key to decode unknown words and phrases in the narratives. | 2010-04-29 |
20100105017 | CENTRAL CONTROL FOR WEB-BASED HEALTH CARE TRAINING - A computer-implemented method and system centrally control web-based training courses for a plurality of staff members in a medical institution. A set of different training courses is accessible via an internet interface and a set of different job descriptions for the staff members. Each job description is assigned to a subset of training courses. The subset of training courses refers to training courses, which have to be completed by the staff member and which are indicative of a qualification of the staff member. For each staff member it is recorded which training courses he already has completed successfully and which training courses he still has to take, taking into account the assigned subset of training courses for his job description, which are provided as a suggestion for training courses to be taken by the staff member. | 2010-04-29 |
20100105018 | PASSIVE EDUCATION METHOD AND DEVICE - A method, device, and kit that utilizes tabletop education displays to allow parents and educators to expose the basic fundamentals of Education to subjects throughout the early developmental stages of learning; then, building on the basics, exposes the subject to more complex ideas. It also has the advantage of being customized in the final stage to the interest or strength of a subject. This provides the parents or educator the ability to challenge and develop the subject in its area of interest. | 2010-04-29 |
20100105019 | Wireless-Enabled Group Motion Signals Gathering Apparatus - The present invention uses motion detecting ribbons bound to moving parts of bodies. A teacher projects material on a screen. Motion statuses of students are detected by the motion detecting ribbons to be projected on the screen too. In this way, a learning environment becomes highly interactive while interactions are improved with the moving parts of bodies. | 2010-04-29 |
20100105020 | QUANTITATIVE MEASUREMENT OF GLYCATED HEMOGLOBIN - The invention relates to a method for quantitative measurement of glycated hemoglobin (HbAIc) in a blood sample containing hemoglobin molecules. In this method, the hemoglobin molecules are extracted from the blood sample, adsorbed onto a roughened metal surface and subjected to a Surface Enhanced Raman Scattering (SERS) measurement. The invention provides a universal method for the measurement of the HbAIc concentration in blood. | 2010-04-29 |
20100105021 | STABILISATION OF BIOLOGICAL CELL MARKERS - The invention provides compositions which stabilise the expression of cell surface markers. The invention further provides methods and kits comprising such compositions for use in stabilising the expression of cell surface markers. The invention is especially concerned with compositions for use in stabilising the expression of cell surface markers (such as cell activation markers) present on blood cells, such as platelets. The invention extends to methods, apparatus and kits for detecting platelet activation, and to kits for monitoring the efficacy of anti-thrombotic treatment regimes. | 2010-04-29 |
20100105022 | ANALYZING BIOLOGICAL CELL MATERIAL BASED ON DIFFERENT INTERACTIONS BETWEEN ILLUMINATION LIGHT AND CELL COMPONENTS - It is described a device ( | 2010-04-29 |
20100105023 | In Vitro Method Modeling The Consistency Generated In Vivo By Food During The Digestion Thereof - The present invention relates to an in vitro method modeling and measuring the consistency generated in vivo by a food during the digestion thereof, comprising the following steps:
| 2010-04-29 |
20100105024 | RAPID TEST INCLUDING GENETIC SEQUENCE PROBE - A rapid test kit may have a genetic probe, and antibody detecting probe or a combination of a genetic probe and an antibody detecting probe disposed within one or more test windows of the test kit. A cellulose filter paper membrane with a flow rate selected in a range of about 0.04 to about 0.4 ml/min/cm | 2010-04-29 |
20100105025 | DEVICES FOR GENERATING DETECTABLE POLYMERS - This document provides systems, devices, and methods involved in generating detectable polymers. For example, diagnostic systems, diagnostic devices, primer systems, and collections of primer systems are provided. | 2010-04-29 |
20100105026 | Optical measurement method for molecular detection using relaxation measurement in optically anisotropic nanoparticles and device for performing the method - Optical measurement methods are described that are suitable for determining the relaxation behavior of nanoparticles dispersed in a solution. The particles have optically anisotropic properties and are alignable by an external stimulus, for example, an electric or magnetic field. In this manner the optical detection of certain molecules that can bind specifically to the surface of the nanoparticles and thus change the relaxation behavior of the nanoparticles as well as to provide devices for carrying out the methods is possible. | 2010-04-29 |
20100105027 | DETECTION OF NUCLEIC ACIDS FROM MULTIPLE TYPES OF HUMAN PAPILLOMAVIRUSES - Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products are disclosed. | 2010-04-29 |
20100105028 | PROBE FOR DETECTING NUCLEIC ACIDS - The invention relates to a probe for detecting nucleic acids, to a method for producing the probe, methods for carrying out analytical reactions and test kits containing the reagents that are required for carrying out the probe-based analytical reaction. | 2010-04-29 |
20100105029 | Self-contained biological analysis - Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyses include nucleic acid amplification and detection and immuno-PCR. | 2010-04-29 |
20100105030 | NUCLEIC ACID BASE PAIRS - The invention relates to non-natural bases and base pairs that expand the normal DNA-based encoding system. Compositions herein may comprise at least one non-natural base that may interact with another base via a Watson Crick-type hydrogen bonding geometry and/or a Hoogsteen-type hydrogen bonding geometry. The bases may be used in a molecular entity, such as an oligomer or any other entity wherein the bases are attached to a backbone. For example, they may be comprised in DNA, RNA, or PNA, or a variety of other nucleic acid-type systems. | 2010-04-29 |
20100105031 | METHOD FOR PREDICTION OF THE EFFICACY OF VASCULARIZATION INHIBITOR - Disclosed is a method for the prediction of the efficacy of a vascularization inhibitor. In the method, the anti-tumor effect of a vascularization inhibitor can be predicted by measuring the number of blood vessels surrounded by pericytes in a tumor and using the measurement value as a measure for the anti-tumor effect. | 2010-04-29 |
20100105032 | HIGHLY SENSITIVE MULTIPLEX SINGLE NUCLEOTIDE POLYMORPHISM AND MUTATION DETECTION USING REAL TIME LIGASE CHAIN REACTION MICROARRAY - A method and apparatus for real-time, simultaneous, quantitative measurement of one or more single nucleotide polymorphisms in one or more target nucleic acids is provided. This method involves combining a ligase chain reaction (LCR), a ligase detection reaction (LDR), and/or a polymerase chain reaction (PCR) technique with an evanescent wave technique. | 2010-04-29 |
20100105033 | METHOD FOR SINGLE NUCLEOTIDE POLYMORPHISM AND MUTATION DETECTION USING REAL TIME POLYMERASE CHAIN REACTION MICROARRAY - A method and apparatus for real-time, simultaneous, qualitative measurement of one or more single nucleotide polymorphisms in one or more target nucleic acids is provided. This method involves combining a polymerase chain reaction (PCR) technique with an evanescent wave technique. | 2010-04-29 |
20100105034 | DETECTING AND TREATING DEMENTIA - This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals. | 2010-04-29 |
20100105035 | ELECTROLUMINESCENT-BASED FLUORESCENCE DETECTION DEVICE - The present invention provides compositions providing and methods using fluorescence detection device, comprising an electroluminescent light (EL) source, for measuring fluorescence in biological samples. In particularly preferred embodiments, the present invention provides an economical, battery powered and Hand-held device for detecting fluorescent light emitted from reporter molecules incorporated into DNA, RNA, proteins or other biological samples, such as a fluorescence emitting biological sample on a microarray chip. Further, a real-time hand-held PCR Analyzer device comprising an EL light source for measuring fluorescence emissions from amplified DNA is provided. | 2010-04-29 |
20100105036 | SIR2 Activity - This invention relates to methods of screening compounds that modulate cellular and organismal processes by modification of the activity of SIR2 and/or transcription factors, e.g., p53, particularly methods of screening for compounds that modify lifespan and/or metabolism of a cell or an organism by modulation of the activity of SIR2 and/or transcription factors, e.g., p53, and more particularly to methods of screening for compounds that modulate the activity of Sir2 and/or transcription factors, e.g., p53. In particular, the present invention relates to a method for screening a compound, by providing a test mixture comprising a transcription factor, Sir2, and a Sir2 cofactor with the compound, and evaluating an activity of a component of the test mixture in the presence of the compound. The invention further relates to therapeutic uses of said compounds. The invention further relates to a method of modifying the acetylation status of a transcription factor binding site on histone or DNA by raising local concentrations of Sir2. | 2010-04-29 |
20100105037 | METHODS FOR AMPLIFYING AND DETECTING NUCLEIC ACID SEQUENCES - The present invention, in different aspects and embodiments, provides nucleic acid amplification and detection methods that are both sensitive and fast. In various aspects there are disclosed amplification methods employing different combinations of primers to which can achieve exponential amplification and strand displacement, such as to generate a more than two fold increase of the amount of a target nucleic acid sequence during repeated cycles, while additionally permitting the production of single stranded products. Also provided are detection systems and kits. | 2010-04-29 |
20100105038 | GENETIC MARKERS FOR WEIGHT MANAGEMENT AND METHODS OF USE THEREOF - This application relates to methods and tests that allow for the establishment of personalized weight-loss programs for a subject based upon the subject's metabolic genotype in key metabolic genes. Kits and methods are disclosed for determining a subject's metabolic genotype, which may be used to select an appropriate therapeutic/dietary regimen or lifestyle recommendation based upon the likelihood of a subject's responsiveness to certain diets and activity levels. Such a personalized weight-loss program will have obvious benefits (e.g., yield better results in terms of weight loss and weight maintenance) over traditional weight-loss programs that do not take into account genetic information. | 2010-04-29 |
20100105039 | LABEL-FREE COLORIMETRIC DETECTION - The present invention provides a sensor system kit for detecting an analyte, consisting essentially of: a nucleic acid enzyme, wherein the nucleic acid enzyme cleaves a substrate in the presence of the analyte; the substrate for the nucleic acid enzyme, comprising a polynucleotide; an aggregator; and particles. | 2010-04-29 |
20100105040 | MICROFLUIDIC SYSTEMS INCLUDING POROUS POLYMER ELECTRODES - Microfluidic devices that incorporate a porous polymer electrode assemblies, including microfluidic device useful for detection of nucleic acids, as well as methods of using the microfluidic devices. | 2010-04-29 |
20100105041 | REAGENTS AND METHODS FOR DETECTING CYP2D6 POLYMORPHISMS - The present invention relates to oligonucleotide sequences for amplification primers and detection probes and their use in nucleic acid amplification methods for the specific detection of clinically relevant CYP2D6 polymorphisms, in particular CYP2D6 polymorphisms associated with adverse drug response. The oligonucleotide sequences are also provided assembled as kits that can be used to predict how an individual will respond to drugs or other xenobiotic compounds that are metabolized, at least in part, by CYP2D6. | 2010-04-29 |
20100105042 | NOVEL METHODS - The present invention provides methods for site-specifically integrating at least one first nucleic acid into a genome of at least one cell, comprising:
| 2010-04-29 |
20100105043 | METHODS FOR MODULATING EMBRYONIC STEM CELL DIFFERENTIATION - Described herein is Zscan4, a gene exhibiting 2-cell embryonic stage and embryonic stem cell specific expression. Identification of nine Zscan4 co-expressed genes is also described Inhibition of Zscan4 expression inhibits the 2-cell to 4-cell embryonic transition and prevents blastocyst implantation, expansion and outgrowth. Provided herein are methods of inhibiting differentiation of a stem cell, promoting blastocyst outgrowth of embryonic stem cells and identifying a subpopulation of stem cells expressing Zscan4. Further described is the identification of Trim43 as a gene exhibiting morula-specific expression. Also provided are isolated expression vectors comprising a Zscan4 promoter, or a Trim43 promoter operably linked to a heterologous polypeptide and uses thereof. Further provided are transgenic animals comprising transgenes encoding marker proteins operably linked to Zscan4 and Trim43 promoters. | 2010-04-29 |
20100105044 | ILEAL POUCH-ANAL ANASTOMOSIS (IPAA) FACTORS IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE - A common long term problem after Ileal Pouch-Anal Anastomosis (IPAA) is the inflammation of the pouch, called pouchitis. Additionally, about 5-10% of patients undergoing IPAA with a diagnosis of ulcerative colitis at the time of surgery are subsequently diagnosed with Crohn's disease. In one embodiment, the present invention provides methods of diagnosing and predicting susceptibility to pouchitis after IPAA by detecting the presence or absence of pANCA and/or Cbir1 Flagellin expression. | 2010-04-29 |
20100105045 | DNP63A Gene and Screening Methods of Anticancer Agent by Using it - This invention relates to a gene encoding ΔNp63α and screening methods of anticancer-drugs thereof, more specifically a gene encoding ΔNp63α and a protein which is transported from nucleus to cytoplasm by contacting with potential anti-cancer-drugs in an epithelial cell carcinoma, a recombinant vector comprising said gene and reporter genes, and carcinoma cells comprising said vector. Also, This invention relates to high throughput screening methods of anticancer-drug comprising identifying the transportation of ΔNp63α protein from nucleus to cytoplasm by contacting with potential anticancer-drug in a carcinoma cell. | 2010-04-29 |
20100105046 | METHODS OF DIAGNOSING CARDIOVASCULAR DISEASE - The invention relates to predicting which individuals are at risk of developing atherosclerotic vascular disease, and once having disease, which individuals are at risk of experiencing plaque rupture which, depending on the site of the plaque, could produce myocardial infarction, stroke, critical limb ischemia, or other vascular event. The invention further relates to methods of diagnosing and aiding in the diagnosis of vascular conditions such as atherosclerosis, premature coronary artery disease and coronary artery disease, by detecting a resistin gene product in an individual. The invention further relates to methods of predicting, and aiding in predicting, the likelihood that an individual will experience a vascular event, such as but not limited to, a myocardial infarction, acute coronary syndrome, stroke, transient ischemic attack (TIA), or critical limb ischemia. | 2010-04-29 |
20100105047 | Method for the Simultaneous Determination of Blood Group and Platelet Antigen Genotypes - RBC and platelet (Plt) alloimmunization requires antigen-matched blood to avoid adverse transfusion reactions. Some blood collection facilities use unregulated Abs to reduce the cost of mass screening, and later confirm the phenotype with government approved reagents. Alternatively, RBC and Plt antigens can be screened by virtue of their associated single nucleotide polymorphisms (SNPs). We developed a multiplex PCR-oligonucleotide extension assay using the GenomeLab SNPStream platform to genotype blood for a plurality of blood group antigen-associated SNPs, including but not limited to: RhD (2), RhC/c, RhE/e, S/s, K/k, Kp | 2010-04-29 |
20100105048 | FUNCTIONALIZED FLUORESCENT NANOCRYSTAL DETECTION SYSTEM - The present invention include fluorescent nanocrystals which have high fluorescence intensity, are water soluble, exhibit physical and chemical stability, and whose spectral properties are detectably modified as the size of functional groups bonded to the nanocrystal surface change when contacted with target molecules in a sample. The molecules in the sample add to or reduce the size of functional groups on the fluorescent nanocrystal proportional to the activity and amount of the target molecules. The present invention may be used to detect telomerase in a sample. | 2010-04-29 |
20100105049 | PROCESSES AND COMPOSITIONS FOR METHYLATION-BASED ENRICHMENT OF FETAL NUCLEIC ACID FROM A MATERNAL SAMPLE USEFUL FOR NON INVASIVE PRENATAL DIAGNOSES - Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies. | 2010-04-29 |
20100105050 | REAL TIME DETECTION OF GENETIC SEQUENCES USING A BIPARTITE PROBE - The present invention concerns a method for detection or quantification of a Target Genetic Sequence in a Genetic Sample using a Bipartite Probe. A Bipartite Probe is made of a Target Binding Sequence capable of hybridizing a Target Genetic Sequence and a Nucleic Acid Binding Probe Sequence capable of being transcribed during PCR into the Capture Probe Sequence where it can hybridize with a Signal Generation Molecule. The Signal Generation Molecule participates in the PCR reaction and confers a fluorescent quality to the PCR amplified product. The reaction temperature of each PCR cycle is reduced below the Tm of the Quencher Oligonucleotide thereby allowing quenching of the fluorescence of the non-incorporated Signal Generation Molecule. Fluorescent detection of each PCR cycle establishes a quantitative PCR result. | 2010-04-29 |
20100105051 | COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF BREAST CANCER - The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided. | 2010-04-29 |
20100105052 | Nucleic acid sequencing and process - The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid templates to amplification methods to form nucleic acid nanoballs. The invention also includes methods of detecting and identifying sequences using various sequencing applications, including sequencing by ligation methods. | 2010-04-29 |
20100105053 | APTAMER BASED SENSORS AND RELATED METHODS AND SYSTEMS - An aptamer based-sensor comprising: a target binding aptamer attaching a Raman probe and a metal coated surface; and related methods and systems | 2010-04-29 |
20100105054 | GENE EXPRESSION IN DUCHENNE MUSCULAR DYSTROPHY - Gene expression in peripheral blood from individuals with Duchenne muscular dystrophy (DMD), compared to control individuals, demonstrated differential gene sets that could be used in a method to diagnose DMD, to evaluate effect of DMD therapy, and/or to evaluate propensity to DMD. | 2010-04-29 |
20100105055 | SYSTEMS AND METHODS OF ANALYZING NUCLEIC ACID POLYMERS AND RELATED COMPONENTS - Systems and methods of identifying, sequencing and/or detecting nucleic acid polymers, as well as related components (e.g., substrates, software and the like) are disclosed. | 2010-04-29 |
20100105056 | Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two dimentional array - This invention relates to methods and apparati for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array, such as a gel, membrane, tissue biopsy, etc. Such manipulations particularly include assays and nucleic acid amplification protocols. | 2010-04-29 |
20100105057 | HUMAN DIABETES SUSCEPTIBILITY TNFRSF10D GENE - The present invention relates to a diagnostic method of determining whether a subject is at risk of developing type 2 diabetes, which method comprises detecting the presence of an alteration in the TNFRSF10D gene locus in a biological sample of said subject. | 2010-04-29 |
20100105058 | Method for Measuring DNA Methylation - The present invention relates to a method of measuring the content of methylated DNA in a DNA region of interest in a genomic DNA contained in a biological specimen, and so on. | 2010-04-29 |
20100105059 | ASSAY FOR CHLAMYDIA TRACHOMATIS BY AMPLIFICATION AND DETECTION OF CHLAMYDIA TRACHOMATIS PMPA GENE - A region of the | 2010-04-29 |
20100105060 | FAST RESULTS HYBRID CAPTURE ASSAY ON AN AUTOMATED PLATFORM - The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample. | 2010-04-29 |
20100105061 | AUTOIMMUNE GENES IDENTIFIED IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) - The present invention relates to a genes and autoimmunity. More specifically, the invention relates to the identification of genes that are associated with Systemic Lupus Erythematosus (SLE) in children and/or adults. Also disclosed are methods for making and using the genetic selection tool used to identify SLE associated genes, and their uses in diagnosis and treatment of the disease. | 2010-04-29 |
20100105062 | Genetic Markers for Optimizing Treatment for Schizophrenia - This document provides methods and materials related to genetic markers for predicting response to a treatment for schizophrenia (SZ). For example, methods for using such genetic markers to select optimal treatments are provided. | 2010-04-29 |
20100105063 | Methods for evaluating the methylation status of a polynucleotide - The invention provides methods related to evaluating the methylation status of a polynucleotide that includes an internal control. | 2010-04-29 |
20100105064 | METHOD OF SCREENING TEST SUBSTANCES FOR TREATING OR PREVENTING A DISEASE MEDIATED BY PLASMA CELLS - The present invention relates to a method of screening a compound for potential effectiveness in treating or preventing a mammalian disease mediated by plasma cells or a mammalian disease caused by virus infection of mammalian cells. Compounds are tested for their ability to inhibit IRE1-mediated processing of untranslatable XBP-1 mRNA into translatable XBP-1 mRNA. Drugs that are useful in treating or preventing a mammalian disease mediated by plasma cells and a method for detecting XBP-1 activity in living cells are also described. | 2010-04-29 |
20100105065 | Miniaturized Fluid Delivery and Analysis System - The present invention provides a method for combining a fluid delivery system with an analysis system for performing immunological or other chemical of biological assays. The method comprises a miniature plastic fluidic cartridge containing a reaction chamber with a plurality of immobilized species, a capillary channel, and a pump structure along with an external linear actuator corresponding to the pump structure to provide force for the fluid delivery. The plastic fluidic cartridge can be configured in a variety of ways to affect the performance and complexity of the assay performed. | 2010-04-29 |
20100105066 | Tissue Rejection - This document relates to methods and materials involved in detecting tissue rejection (e.g., organ rejection). For example, this document relates to methods and materials involved in the early detection of kidney tissue rejection. | 2010-04-29 |
20100105067 | BIOMARKERS FOR OVARIAN CANCER - The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry. | 2010-04-29 |
20100105068 | HYBRIDOMAS PRODUCING ANTIBODIES AGAINST NON FUNCTIONAL P2X7 RECEPTOR - The present invention relates to the production of anti non functional P2X7 receptor monoclonal antibodies from hybridoma cell lines. | 2010-04-29 |
20100105069 | METHOD FOR DETECTING HUMAN PARVOVIRUS ANTIGEN - A method for detecting human parvovirus/erythrovirus antigen in a sample comprises contacting a buffer having a pH in the range 3.0 to 4.0, suitably a citrate/trisodium citrate buffer, with the sample followed by the measurement of the antigen. The measurement of the antigen can be by virus capture enzyme immunoassay. The method is a good indicator of recent infection and can be used in the screening of individual plasma units or pools from which blood products are extracted. | 2010-04-29 |
20100105070 | DIAGNOSIS AND TREATMENT OF PREECLAMPSIA - The present invention relates to biomarkers for preeclampsia as well as treatment of this disease. In particular, the invention relates to methods for diagnosis or aiding in the diagnosis of preeclampsia of a pregnant female mammal to detect elevated levels of free haemoglobin, particularly free fetal haemoglobin. This facilitates and makes possible early diagnosis and clinical intervention when a preeclamptic condition is found. In addition, the invention relates to a method to treat female mammals with preeclampsia with the purpose to reverse the pathological conditions associated with this disease. | 2010-04-29 |
20100105071 | METHODS FOR PREDICTING THE ONSET OF MENARCHE - Embodiments of the invention provide methods for predicting the onset of menarche, i.e. a females first menstrual period, through the measurement of salivary hormone levels (e.g. 17-β estradiol, testosterone, progesterone, and/or 17 hydroxy-progesterone (17-OHP)). In particular, the methods described herein enable a reliable determination that menarche will, or will not occur, within varied time intervals, e.g. 1 to 30 days, 1 to 45 days, 1 to 60 days and 1 to 90 days. Diagnostic kits and products of manufacture comprising the kits are also provided. | 2010-04-29 |
20100105072 | Methods of identifying respondents to hypoxia inducible factor 1-alpha inhibitors - This invention relates to methods of measuring HIF expression and activity, as well as measuring inhibition of HIF following administration of an HIF inhibitor useful in treating HIF related diseases. The present invention further relates to methods of identifying individuals who will respond to HIF inhibitors. The invention also relates to methods of monitoring a patient response to a given dosage of an HIF inhibitor. The invention also includes assays and kits for performing the methods described herein. | 2010-04-29 |
20100105073 | METHOD FOR THE PRODUCTION OF ANTIBODIES - The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell. | 2010-04-29 |
20100105074 | HIGH THROUGHPUT FLOW CYTOMETRY SYSTEM AND METHOD - The invention provides systems, compositions, kits and methods for automated processing of biological samples and analysis using a flow cytometer. | 2010-04-29 |
20100105075 | SYSTEMS AND METHODS OF VOLTAGE-GATED ION CHANNEL ASSAYS - Systems and methods are provided for optically measuring ion concentrations in biological samples. The systems and methods employ polymer-based optical ion sensors that include ion-selective ionophores and a pH sensitive chromionophore. Electrodes are providing for electrically stimulating the biological samples. | 2010-04-29 |
20100105076 | ANALYSIS KIT COMPRISING AT LEAST TWO MOLECULARLY IMPRINTED POLYMERS AND AT LEAST ONE MARKER, AND METHOD OF ANALYSIS USING SAME - The present invention relates to a kit for analysing at least one target molecule comprising at least a first molecularly imprinted polymer and a second molecularly imprinted polymer which are chemically identical or different, capable of interacting with the target molecule(s), and at least one marker, wherein said marker is either a competitive marker or marker capable of (i) of interacting with all or part of the recognition sites for the target molecule(s) of the second molecularly imprinted polymer and (ii) of being displaced from said recognition site(s) by the target molecule(s) when said molecularly imprinted polymer is placed in the presence of said target molecule(s), or an intrinsic marker or a constitutive unit of the second molecularly imprinted polymer, capable (i′) of interacting with all or part of the target molecule(s) when the latter interact(s) with all or part of its recognition sites for said target molecule(s) and (ii″) of consequently emitting a detectable signal. | 2010-04-29 |
20100105077 | Means for Detection and Purification of CD8+ T Lymphocyte Populations Specific to Peptides Presented in the Context of HLA - The invention concerns multimers developed from recombinant proteins analogues of MHC class I. | 2010-04-29 |
20100105078 | Compositions And Methods Of A Phosphatidic Acid Binding Protein - TGD2 proteins of | 2010-04-29 |
20100105079 | BIO SURFACE ACOUSTIC WAVE (SAW) RESONATOR AMPLIFICATION WITH NANOPARTICLES FOR DETECTION OF A TARGET ANALYTE - The present invention relates generally to a signal amplification method for a SAW resonator microsensor for analyzing test samples, containing target analyte including proteins and nucleic acids. The method comprising the steps: reacting the analyte in a sample with a first molecular recognition component and a second molecular recognition component linked to at least one nanoparticle; and adding an enhancement solution comprising silver ions and/or gold ions, and a reducing agent, whereby the silver ions and/or gold ions are reduced to metallic silver and/or gold which is deposited onto the surface of the at least one nanoparticle; wherein the mass increase of the at least one nanoparticle is detected by a SAW sensor. | 2010-04-29 |
20100105080 | Methods For Determining The Bioactivity Of TGF-Beta In A Composition - A novel method for determining the bioactivity of TGF-β in a sample of milk, raw protein source, or nutritional composition is provided. The method includes particular reconstitution steps, centrifugation steps, incubation steps, and activation steps. The bioactivity of the TGF-β in the sample may be measured in a HT-2 cell bioassay or a cellomics bioassay. | 2010-04-29 |
20100105081 | DETECTING FUNGI IN HUMAN SAMPLES - Methods and materials involved in detecting fungi in human samples are provided herein. | 2010-04-29 |
20100105082 | RAPID DETECTION NANOSENSORS FOR BIOLOGICAL PATHOGENS - An assay test solution, a method for using, and an apparatus for the rapid detection of multiple pathogens using a FRET-based phenomenon. A volume of fluid, possibly containing pathogens, is passed through an intake and combined with an assay solution of quantum dot/antibody-antigen/quencher complexes that dissociate and recombine with the pathogens into quantum dot/antibody-pathogen complexes. The quantum dot/antibody-antigen/quencher and quantum dot/antibody-pathogen complexes are captured on a detection filter which is illuminated by a light source. The quantum dot/antibody-pathogen complexes, but not the quantum dot/antibody-antigen/quencher complexes, fluoresce when excited by the light from the light source and the fluorescence is picked up by a photodetector, indicating the presence of the pathogens. | 2010-04-29 |
20100105083 | Methods For Determining The Levels Of TGF-Beta In A Composition - A novel method for determining the levels of TGF-β1 or TGF-β2 in a sample of milk, raw protein source, or nutritional composition is provided. The method involves, in some cases, reconstituting the sample; in some cases, centrifuging the sample; activating the sample using particular ratios of sample:acid:base; diluting the sample using particular ratios of sample:buffer agent; and determining the concentration of TGF-β1 in the sample using an ELISA assay. | 2010-04-29 |
20100105084 | METHODS AND KITS FOR THE RAPID DETERMINATION OF PATIENTS AT HIGH RISK OF DEATH DURING SEVERE SEPSIS AND SEPTIC SHOCK - The present invention provides for the in vitro establishing of a prognosis for a subject in severe sepsis with at least two organ failures or in septic shock with at least two organ failures. Embodiments of the invention comprise the steps of measuring the level of the S100A8/A9 complex from a biological sample from a subject, and comparing the measured level to a predetermined threshold in which the measured level of the S100A8/A9 complex above the predetermined threshold is indicative of a bad prognosis and a measured level of the S100A8/A9 complex below the predetermined threshold is indicative of a good prognosis. | 2010-04-29 |
20100105085 | METHOD OF DIAGNOSING AND STRATIFYING ANTI-PHOSPHOLIPID SYNDROME - Disclosed are a method and reagents for diagnosis of anti phospholipid syndrome based on the levels of certain anti 1 can antibodies. | 2010-04-29 |
20100105086 | DIFFERENTIAL DIAGNOSIS FOR SCLERODERMA - Use of IFI16 protein, fragments or peptides thereof for differential diagnosis of the limited cutaneous form of scleroderma (Ic-SSc) in a subject suspected of or at risk of having an autoimmune disease and the corresponding method of diagnosis and kit. | 2010-04-29 |
20100105087 | BIOMARKERS FOR BREAST CANCER - Low molecular weight (LMW) peptides have been discovered that are indicative of breast cancer. Evaluating patient samples for the presence of such LMW peptides is an effective means of detecting breast cancer and monitoring the progression of the disease, for example during treatment. The LMW peptides are particularly useful in detecting breast cancer during its early stages. | 2010-04-29 |
20100105088 | METHOD FOR DIAGNOSING ATHEROSCLEROTIC PLAQUES BY MEASUREMENT OF CD36 - The present invention relates to diagnosis, classification and monitoring of atherosclerotic plaques in an individual using measurement of the concentration of CD36 in a body fluid and/or the plaque as such. The present invention also relates to diagnosing the burden of atherosclerotic plaques in an individual. Furthermore, the invention relates to a method for diagnosing stenosis caused by atherosclerotic plaques. Within the scope of the present invention are also methods for determining the treatment regime of an individual. Kits and oligonucleotides for use in the methods are claimed. | 2010-04-29 |
20100105089 | QUANTUM DOT BIOTAGS - A biotag that includes a biomolecule that includes a bio polymer sequence; an attaching polymer attached at an endpoint of the biopolymer sequence; and a quantum dot bound to the attaching polymer causing the attaching polymer to become fluorescently labeled is provided. Suggested biomolecules include, but are not limited to, peptides, proteins, amino acids, nucleic acids, deoxyribonucleic acids, ribonucleic acids, and peptide nucleic acids. The biopolymer sequence may be or otherwise include a protein sequence. The biomolecule may be located inside a cell, outside a cell, or on a cell. Desirably, a quantum dot is bound to an attaching polymer and, thus the biomolecule, without using any of thiol chemistries, 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide/N-hydroxysuccinimide hydrochloride (EDC/NHS) chemistries, and biotin/avidin chemistries. In certain desirable embodiments, the attaching polymer is attached at an endpoint of a biopolymer sequence using any of synthesizing, replicating, transcribing, translating, and expressing the attaching polymer at any of a C-terminal end or an N-terminal end of the biopolymer sequence. | 2010-04-29 |
20100105090 | SECRETED LUCIFERASE MLUC7 AND USE THEREOF - The invention relates to the nucleotide and amino acid sequences and to the activity and use of the secreted MLuc7 luciferase. | 2010-04-29 |
20100105091 | Method for Measuring the Concentration of Transient Proteolytic Activity in Composite Biological Media Containing Cells - A method is provided for determining in real time the course of thrombin activity in a sample of clotting blood or plasma as it appears in and disappears from the sample which comprises adding a signal substrate to said sample, said signal substrate causing a detectable signal related to the amount of conversion product formed upon reaction by the generated proteolytic activity, monitoring the signal development in time in said sample to provide a curve, and mixing said sample frequently so that clot formation occurs in a dense manner such that the majority of the sample remains fluid and that cell precipitation is inhibited, wherein said monitoring and mixing steps are repeated and performed in an alternate way. | 2010-04-29 |
20100105092 | LIPOLYTIC ENZYME VARIANTS - Variants with increased acyl transferase activity can be designed on the basis of a three-dimensional model by making amino acid alterations near the active Ser of lipolytic enzymes such as | 2010-04-29 |
20100105093 | ASSAY METHOD FOR THE DETECTION OF VIABLE MICROBIAL CELLS IN A SAMPLE - The present invention discloses an assay method for the detection of viable microbial cells in a sample, the assay method comprising the steps of: i) adding an ATP degrading enzyme to a sample suspected of containing viable microbial cells to substantially degrade any extracellular ATP in the sample; ii) adding a phosphate containing compound to the sample to substantially halt action of the ATP degrading enzyme; and iii) subjecting the sample to a detection assay to establish the level of undegraded ATP in the sample to provide an indication of the level of viable microbial cells in the sample. | 2010-04-29 |
20100105094 | METHOD, DEVICE AND APPARATUS FOR MEASURING THE CONCENTRATION OF CREATININE, AND METHOD, DEVICE AND APPARATUS FOR MEASURING THE AMOUNT OF SALT IN URINE USING THE SAME - A method for measuring the concentration of creatinine includes the steps of: (A) mixing a sample containing creatinine with a creatinine quantitative reagent including 1-methoxy-5-methylphenazinium in the absence of picric acid and any enzyme responsive to creatinine, to cause the creatinine to reduce the 1-methoxy-5-methylphenazinium; (B) electrochemically or optically measuring the amount of the 1-methoxy-5-methylphenazinium reduced in the step (A); and (C) determining the concentration of the creatinine contained in the sample from the amount of the reduced 1-methoxy-5-methylphenazinium measured in the step (B). | 2010-04-29 |
20100105095 | Optical Molecular Sensors for Cytochrome P450 Activity - The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe of the invention is a compound having the generic structure Y-L-Q, wherein Y is selected from the group consisting of Q as herein defined, saturated C | 2010-04-29 |
20100105096 | METHOD OF EVALUATING FOAM-HOLDING PROPERTY OF FERMENTED MALT DRINK AND MARKER FOR EVALUATING FOAM-HOLDING - The present invention provides a method for determination of the foam stability of a fermented malt beverage, wherein the concentration of yeast thioredoxin (M | 2010-04-29 |