| 17th week of 2009 patent applcation highlights part 41 |
| Patent application number | Title | Published |
|---|
| 20090104557 | NEGATIVE IMAGING METHOD FOR PROVIDING A PATTERNED METAL LAYER HAVING HIGH CONDUCTIVITY - Disclosed is a method negative imaging method for making a metal pattern with high conductivity comprising providing a patterned substrate comprising a patterned catalyst layer on a base substrate by a thermal imaging method followed by plating to provide the metal pattern. The metal patterns provided are suitable for electrical devices including electromagnetic interference shielding devices and touchpad sensors. | 2009-04-23 |
| 20090104558 | Solution for a Treatment of a Resist, a Modified Resist, a Process for the Treatment of a Resist and an Intermediate Product - Solutions for the treatment of a resist used in the manufacturing of a semiconductor device or masks used in the manufacturing of semiconductor devices are described. Preferably, the solution includes a transition metal organic compound. Furthermore embodiments of modified resists, a process and an intermediate product are described. | 2009-04-23 |
| 20090104559 | Bottom Antireflective Coating Compositions - Developable bottom antireflective coating compositions are provided. | 2009-04-23 |
| 20090104560 | BARRIER FILM MATERIAL AND PATTERN FORMATION METHOD - In exposing a resist film to light with a liquid provided on a positive chemically amplified resist film, a barrier film material for a barrier film formed between the resist film and the liquid includes a compound having an acid leaving group and a thermal acid generator. | 2009-04-23 |
| 20090104561 | High performance, crosslinked polymeric material for holographic data storage - An optical recording material and methods of making such material is provided. The material comprises of a dewar benzene monomer, with at least two cross-linkable groups, a sensitizer, a cross-linker, and an initiator. The material does not require a binder or a co-sensitizer. The material can be fabricated by an exceedingly easy technique that offers high photosensitivity, high diffraction efficiency, millimeter thickness, and high dynamic range. | 2009-04-23 |
| 20090104562 | PHOTOPOLYMERIZABLE COMPOSITION - A composition that is photopolymerizable upon absorption of light and/or heat, the composition including a binder, a polymerizable compound, a sensitizer, and a photoinitiator, characterized in that the composition includes, with respect to its non-volatile compounds, at least about 0.01 wt.-% of a polythiol compound and has a very high sensitivity and hardness. | 2009-04-23 |
| 20090104563 | RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, NOVEL COMPOUND, AND ACID GENERATOR - There is provided a compound represented by a general formula (B1-1) shown below, an acid generator composed of the above compound, a resist composition containing an acid generator composed of the above compound, and a method of forming a resist pattern: | 2009-04-23 |
| 20090104564 | PATTERNING PROCESS - The invention is directed to a method for patterning a material layer. The method comprises steps of forming a mask layer on the material layer. A multiple patterning process is performed on the mask layer for transferring at least a first pattern from a first photomask through a first photoresist and a second pattern from a second photomask from a second photoresist layer into the mask layer without performing any etching process. The mask layer exposes a portion of the material layer and the mask layer is patterned at the time that the first photoresist layer and the second photoresist layer are developed respectively. An etching process is performed to pattern the material layer by using the mask layer as an etching mask. | 2009-04-23 |
| 20090104565 | METHOD FOR FORMING PHOTOELECTRIC COMPOSITE BOARD - In a method for forming a photoelectric composite board ( | 2009-04-23 |
| 20090104566 | Process of multiple exposures with spin castable film - Methods of multiple exposure in the fields of deep ultraviolet photolithography, next generation lithography, and semiconductor fabrication comprise a spin-castable methodology for enabling multiple patterning by completing a standard lithography process for the first exposure, followed by spin casting an etch selective overcoat layer, applying a second photoresist, and subsequent lithography. Utilizing the etch selectivity of each layer, provides a cost-effective, high resolution patterning technique. The invention comprises a number of double or multiple patterning techniques, some aimed at achieving resolution benefits, as well as others that achieve cost savings, or both resolution and cost savings. These techniques include, but are not limited to, pitch splitting techniques, pattern decomposition techniques, and dual damascene structures. | 2009-04-23 |
| 20090104567 | APPARATUS FOR FABRICATING SEMICONDUCTOR DEVICE AND METHOD THEREOF - An apparatus for fabricating a semiconductor device and method thereof are disclosed, by which an angle of light diffracted by a reticle can be decreased in a manner of filling up an empty space between a reticle and a frame with a transparent substance of high purity to maximize real resolution on and/or over a semiconductor wafer. | 2009-04-23 |
| 20090104568 | Exposure method, exposure apparatus, and method for producing device - An exposure method exposes a substrate by projecting an image of a pattern onto the substrate through a liquid by using a projection optical system while moving the substrate in a predetermined direction. A temperature distribution of the liquid in a direction intersecting the predetermined direction is measured. A projection state of the image of the pattern is adjusted on the basis of information about the measured temperature distribution. The substrate is exposed to the image of the pattern in the projection state. | 2009-04-23 |
| 20090104569 | Plane waves to control critical dimension - The present invention describes an aperture including: an opaque plate; two sliver openings located in the opaque plate, the two sliver openings having rectangular shapes, the two sliver openings being parallel to each other. | 2009-04-23 |
| 20090104570 | APERTURED MEDIA EMBELLISHING TEMPLATE AND SYSTEM AND METHOD USING SAME - A multi-function media embellishing template and a system and method of embellishing media with the template is provided. The template includes a body having a media abutment surface and an aperture in the media abutment surface extending through the template, and an embellishing wall extending from the media abutment surface and terminating in an embellishing surface. The media embellishing template can be formed by exposing first and second sides of a template blank not covered by a resist to etchant, etching the surface of the first side to form a media abutment surface and an embellishing wall extending from the media abutment surface and terminating in an embellishing surface, and etching the surface of the second side not covered by the resist to form at least one aperture extending through the template. | 2009-04-23 |
| 20090104571 | Method for air gap formation using UV-decomposable materials - A method of selectively removing a sacrificial material on a substrate is described. The method comprises forming a sacrificial layer on a substrate. Thereafter, the sacrificial layer is selectively decomposed at a temperature less than the temperature required to thermally decompose the sacrificial layer by selectively exposing the sacrificial layer to UV radiation. | 2009-04-23 |
| 20090104572 | COMPOSITION AND METHOD FOR PROVIDING A PATTERNED METAL LAYER HAVING HIGH CONDUCTIVITY - Disclosed is a method for making a metal pattern with high conductivity comprising providing a patterned substrate comprising a patterned catalyst layer on a base substrate by a thermal imaging method followed by plating to provide the metal pattern. The metal patterns provided are suitable for electrical devices including electromagnetic interference shielding devices and touchpad sensors. | 2009-04-23 |
| 20090104573 | Gas burner system - A gas burner system includes a power supply device, one or a number of gas burners, one or a number of gas valve for controlling the fuel gas passage(s) of the gas burner(s), one or a number of control device each having an operating device for inputting a command signal, a microprocessor for receiving the command signal from the operating device and outputting a corresponding control signal, a valve control device for driving the gas valve(s) subject to the control signal from the microprocessor, an ignition induction electrode located on each gas burner at one side, and one or a number of igniter and inductor combination device for providing a high voltage current to the ignition induction electrode at each gas burner subject to the control signal from the microprocessor to cause the ignition induction electrode at each gas burner to discharge sparks for burning the discharged fuel mixture so that the igniter and inductor combination device stops from providing the high voltage current when received a feedback flame signal from the ignition induction electrode and sending the feedback signal to the microprocessor. | 2009-04-23 |
| 20090104574 | Utility Lighter - A utility lighter includes a housing having an elongated tube portion, an actuation button depressibly mounted at a housing portion of the housing, a safety wheel rotated and mounted at the actuation button, and a blocker driven to move by a rotational movement of the safety wheel between an inoperative configuration and an operative configuration. In the inoperative configuration, the blocker is retained in the housing portion of the housing to prevent a depressible head of a piezoelectric element from being depressed by the actuation button for ignition. In the operative configuration, the safety wheel is rotated at the actuation button to drive the blocker to diminish undesirable position, so that the actuation button is depressed to depress the depressible head of the piezoelectric element and to actuate the valve actuator for ignition. | 2009-04-23 |
| 20090104575 | Microencapsulation of fuel for dosage heat release, remote activated - A method for oil-based fuel dispersion in the form of micron and submicron Droplets with typical size distribution 0.5-20 microns where said Droplets are coated with a polymer-based shell containing metal nanoparticles that enable the droplets to absorb laser irradiation and utilize laser energy to initialize fuel burning. | 2009-04-23 |
| 20090104576 | FURNACE USING PLASMA IGNITION SYSTEM FOR HYDROCARBON COMBUSTION - An apparatus and method for the creation, placement and control of an area of electrical ionization within an internal combustion engine combustion chamber or a fuel burner for a furnace is disclosed. A furnace includes a fuel source, a fuel burner, a plasma nozzle and igniter assembly, and the associated housing and flue structures. The plasma nozzle and igniter assembly is arranged so that the fuel sprayed out from the nozzle into the combustion area passes through or in close proximity to the area of plasma ionization. A fuel burner equipped with this electrical ionization device has its fuel efficiency enhanced by the complete and immediate combustion of substantially all of the fuel that passes through the area of plasma ionization. Exhaust gas recirculation using this system is also disclosed. | 2009-04-23 |
| 20090104577 | Candle with an Embedded Magnet or Ferromagnetic Material - A candle is disclosed that contains a small magnet (or ferromagnetic material) embedded in the base of the candle. In one embodiment, the base of a cylindrical candle contains a magnet (or ferromagnetic material) molded into the body of the candle such that a face of the magnet (or ferromagnetic material) is substantially co-planar with the base of the candle. The magnet (or ferromagnetic material) can have an irregular cross section along the length of the candle, thereby aiding retention of the magnet (or ferromagnetic material) within the candle body. | 2009-04-23 |
| 20090104578 | ORTHODONTIC BRACKET AND PROCESS FOR PRODUCING THE SAME - A method for producing an orthodontic bracket is comprised of sintering a molded body of highly-pure alumina fine powder at a temperature of 1,200° C. to 1,300° C. to obtain a sintered body composed of crystals having a relative density of 96% to 99.5% and an average crystal grain size of at most 1 μm, and thereafter subjecting the sintered body to an HIP treatment at a temperature of 1,200° C. to 1,350° C., under a pressure of at least 50 MPa. Such an orthodontic bracket has high strength and high translucency, can be processed into a complicated shape, similar to that of a metal bracket, and maintains excellent translucency. | 2009-04-23 |
| 20090104579 | Mixing Device - A mixing apparatus has a mixing base on which components of a material, in particular a ceramic material, which are to be kept moist, are to be mixed, and a liquid reservoir and moistening means which communicate with the liquid reservoir and which are arranged and adapted to keep moist components which are to be kept moist, wherein the moistening means include a liquid carrier of an elongate configuration which provides for liquid transport in the longitudinal direction thereof and allows liquid delivery to components which are to be kept moist over the surface of the liquid carrier in transverse relationship with the longitudinal direction and which on the one hand is in communication with the liquid reservoir and which on the other hand adjoins a mixing surface on the mixing base. | 2009-04-23 |
| 20090104580 | FLUID AND PULSED ENERGY OUTPUT SYSTEM - A fluid conditioning system is adapted to condition the fluid used in medical and dental cutting, irrigating, evacuating, cleaning, and drilling operations. The fluid may be conditioned by adding flavors, antiseptics and/or tooth whitening agents such as peroxide, medications, and pigments. In addition to the direct benefits obtained from introduction of these agents, the laser cutting properties may be varied from the selective introduction of the various agents. | 2009-04-23 |
| 20090104581 | Dental Restoration Device - A device for anatomically restoring a tooth having a proximal caries ( | 2009-04-23 |
| 20090104582 | Male threaded implant drill - The Male Threaded Implant Drill will assist in the process that will allow a surgeon to place a dental implant in the mandible and/or maxilla bone(s) while working in conjunction with a stent. The Male Threaded Implant Drill is used in the placement of a surgical dental implant perfectly parallel to other dental implant(s) and root structures. The Implant Drill is used in conjunction with a surgical dental implant stent that will allow a surgeon to place dental implant(s) at a predetermined depth within the mandible and/or maxilla of a patient undergoing surgery. | 2009-04-23 |
| 20090104583 | Method for Designing an Abutment - A method for designing an abutment tooth which mainly comprises the steps of: setting a reference abutment device with a feature on an analog of a mouth model; positioning a digital abutment with the same configuration as the reference abutment device on the analog to obtain the configuration data of the positioning of the digital abutment on the analog; optimally adjusting the digital abutment by using as a reference the configuration digital data without affecting the configuration of the digital abutment and the analog, thus finishing the design of the abutment. | 2009-04-23 |
| 20090104584 | Incisor tooth or canine tooth, and set of teeth, and method for producing and incisor tooth or canine tooth - The invention relates to an anterior tooth such as an incisor tooth or canine tooth built up in layers, with a cutting-edge material ( | 2009-04-23 |
| 20090104585 | DENTAL FRAMEWORK - A method of preparing a dental framework or mathematical model thereof comprises creating a replica of a patient's mouth or a framework to be inserted into the patient's mouth, electronically scanning the replica or framework, electronically determining a surface model of a dental framework and manufacturing the framework. | 2009-04-23 |
| 20090104586 | Collagen Antral Membrane Expander - A subantral membrane elevator comprising an inflatable balloon and an over-formed membrane (e.g., collagen membrane), which is resorbable into the body, and a method of using the same in bone augmentation surgery, such as alveolar bone augmentation preparatory to implantation of a dental implant. | 2009-04-23 |
| 20090104587 | Defining an insertion indicator - Methods and apparatuses to define an insertion indicator on a Braille device are described. Information about an insertion indicator at a location on a display device is received. An output associated with the insertion indicator is provided to a Braille device. The output to the Braille device reproduces the location of the insertion indicator on the display device. The output associated with the insertion indicator may be provided to at least two cells of the Braille device. The output to the Braille device may be provided to raise a first dot of a first Braille cell on the Braille device, wherein the first Braille cell corresponds to a second location that precedes the first location on the display device. A Braille caption panel may be displayed on a display device, the Braille caption panel includes a simulation of the output associated with the insertion indicator on the Braille device. | 2009-04-23 |
| 20090104588 | Topographic Map that Can be Visually Perceived in a Three-Dimensional Manner - The invention relates to topographic maps which can be visually perceived in a three-dimensional manner and in which a pre-definable part of a territory is printed on a planar rear face of a lenticular foil in the form of strip images or a carrier that has been printed in this manner is adhesively bonded to or placed directly on the planar rear face of a lenticular foil. In order to increase the information content of such topographic maps, regions comprising thematic data which can be visually perceived in a two-dimensional form from pre-definable angles of observation are printed underneath cylindrical lenses of the lenticular foil in addition to strip images | 2009-04-23 |
| 20090104589 | SYSTEMS AND METHODS FOR PROVIDING REMOTE TRAINING FOR A QUALITY ANALYSIS PROGRAM - Systems and methods for providing remote training for a quality analysis program are disclosed. In certain embodiments, a computer-implemented method for providing remote training for a quality analysis program may comprise transmitting a first portion of a training program for a quality analysis program to a remote communication device, receiving a first transmission from the remote communication device, and transmitting a second portion of a training program to the remote communication device. | 2009-04-23 |
| 20090104590 | INTERACTIVE BOOK SYSTEM BASED ON ULTRASONIC POSITION DETERMINATION - In an interactive system for interacting with a printed material having at least a visual icon associated with predetermined response data, there is an ultrasonic pointing unit positionable over the at least one visual icon and arranged for generating ultrasonic wave. An ultrasonic positioning base unit is arranged for receiving the ultrasonic wave from the ultrasonic pointing unit and determining a position of the ultrasonic pointing unit based on the received ultrasonic wave. A is arranged for locating, in a data storage, the response data corresponding to the visual icon according to the position of the ultrasonic pointing unit. A response unit is arranged for outputting the response data. | 2009-04-23 |
| 20090104591 | SYSTEM AND METHOD FOR LEARNING ENHANCEMENT BASED ON A SPORTS GAME - A method of practicing educational exercises in the context of a simulated professional competitive sports game. The method includes assembling teams of students to compete against each other in the competitive sports game. Questions are posed to students during play of the sport and the correctness and time of response determines play outcome in the sport. Students have opportunities to make strategy decisions within the sports game context and such strategy decisions can result in harder or easier questions being posed depending on the potential reward of playing one strategy over another. The disclosure is based on baseball as the competitive background, while performing similar exercises in the context of other sports is equally possible. | 2009-04-23 |
| 20090104592 | Lights Out Learning - A computer implemented method, apparatus, and computer program product for presenting interactive, educational content using a projector. In one embodiment, a set of learning modules associated with a subject matter is selected to form educational content. The educational content is displayed on a surface, by the projector. The educational content comprises a question. An answer for the question is received. In response to a determination that the answer for the question is a correct answer, a reward light show is displayed on the surface by the projector. | 2009-04-23 |
| 20090104593 | Preparation and Use of Basement Membrane Particles - A method for supporting the in vitro growth of one or more eukaryotic cell type(s), the method comprising; seeding cells of said cell type(s) onto particles comprising basement membrane or a basement membrane-like substrate, and culturing said seeded cells in vitro under conditions suitable for expansion of said seeded cells, wherein said particles are less than about 500 μm in size. | 2009-04-23 |
| 20090104594 | Bioreactor Process Control System and Method - A bioreactor includes a sensor linked to a model free adaptive controller or optimizer. The sensor can provide a real time measurement of a quantity that correlates with final product titer or other desired product quality attribute. | 2009-04-23 |
| 20090104595 | Methods for determining the sensitivity or resistance of retrovirus isolates to therapeutic retroviral treatments based on viral protease inhibitors and diagnostic kits - A method for determining sensitivity or resistance of isolates of HIV (human immunodeficiency virus) retroviruses to chemical molecules having an inhibiting activity on a viral protease or to therapeutic treatments based on inhibitors of the viral protease, including causing cell lysis of at least one yeast by expression of the retrovirus protease. | 2009-04-23 |
| 20090104596 | Noninvasive Measurement and Identification of Biomarkers in Disease State - The invention is methods and related kits for diagnosing a disease state of cachexia by measuring biomarker profiles from a biological sample. Rapid measurement of early onset or progression of the disease in a subject is determined by measuring biomarker levels from the subject and optionally comparing the biomarker levels to a standard biomarker profile or metabolome phase portrait for the disease. The biomarkers measured in the assay and related kit for cachexia progression include biomarkers selected from the group consisting of lactate, citrate, formate, acetoacetate, 3-hydroxy butrate, alanine, glutamine, glutamate, valine, isoleucine leucine, thrionine, lysine, arginine, tyrosine, phenyl alanine, histidine and tryptophan. | 2009-04-23 |
| 20090104597 | ADVANCED CERVICAL CELL SCREENING METHODS - Advanced cervical cancer screening methods that provide a molecular based process of detecting HPV-integration. The disclosed methods allow for a streamlined approach of conducting a Pap test and immunohistochemical test on the same slide. The disclosed methods provides an inexpensive, highly sensitive, specific, and detailed test that is easy to evaluate and follow-up. | 2009-04-23 |
| 20090104598 | Dopamine D2 receptor gene variants - The present invention provides a method of predicting antipsychotic response to drug therapy comprising testing a sample obtained from a subject for the presence of a polymorphism in the dopamine D2 receptor gene DRD2, wherein the presence of the rs1079598T allele, the rs1125394A allele or both is predictive of the subject being susceptible to drug therapy. | 2009-04-23 |
| 20090104599 | GENETIC VARIANT OF THE ANNEXIN A5 GENE - The present invention relates to a nucleic acid molecule comprising an annexin A5 (ANXA5) gene regulation element which comprises at least one point mutation, whereby said at least one point mutation (substitution) is selected from the group consisting of (i) a point mutation G to A at a position which corresponds to nucleotide 186 of SEQ ID NO: 2; (ii) a point mutation A to C at a position which corresponds to nucleotide 203 of SEQ ID NO: 2; (iii) a point mutation T to C at a position which corresponds to nucleotide 229 of SEQ ID NO: 2; and (iv) a point mutation G to A at a position which corresponds to nucleotide 276 of SEQ ID NO: 2. Furthermore, the present invention provides for a vector comprising the nucleic acid molecule the invention and a host transformed with the vector. The invention also relates to specific uses, in particular diagnostic uses of the nucleic acid molecules described herein. Moreover, the invention relates to a method for haplotyping an ANXA5 gene regulation element in an individual comprising the steps of: (a) isolating a nucleic acid from a sample that has been removed from the individual; (b) determining the presence of the nucleotides present at positions 186, 203, 229 and 276 of the individual's copy of the ANXA5 gene regulation element, wherein the position numbers are determined by comparison to SEQ ID NO: 2; (c) assigning the individuals a particular haplotype by comparison of the nucleotides present at said positions to the nucleotides recited in the haplotypes as defined herein. | 2009-04-23 |
| 20090104600 | Mutation within the connexin 26 gene responsible for prelingual non-syndromic deafness and method of detection - A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in a wild form encodes a polypeptide implicated in hereditary sensory defect, wherein said mutated purified polynucleotide presents a mutation responsible for prelingual non-syndromic deafness selected from the group consisting of a specific deletion of at least one nucleotide. | 2009-04-23 |
| 20090104601 | GENETIC DIAGNOSIS USING MULTIPLE SEQUENCE VARIANT ANALYSIS - The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention is useful to define the subset of variations that are most suited as genetic markers to search for correlations with certain phenotypic traits. Additionally, the insights are useful for the development of algorithms and computer programs that convert genotype data into the constituent haplotypes that are laborious and costly to derive in an experimental way. The invention is useful in areas such as (i) genome-wide association studies, (ii) clinical in vitro diagnosis, (iii) plant and animal breeding, (iv) the identification of micro-organisms. | 2009-04-23 |
| 20090104602 | Diagnosis of Tuberculosis - The invention provides a method of diagnosing tuberculosis (TB) in a test subject, said method comprising: (i) providing expression data of two or more markers in a subject, wherein at least two of said markers are selected from transthyretin, neopterin, C-reactive protein (CRP), serum amyloid A (SAA), serum albumin, apoliopoprotein-A1 (Apo-A1), apolipoprotein-A2 (Apo-A2), hemoglobin beta, haptoglobin protein, DEP domain protein, leucine-rich alpha-2-glycoprotein (A2GL) and hypothetical protein DFKZp667I032; and (ii) comparing said expression data to expression data of said marker from a group of control subjects, wherein said control subjects comprise patients suffering from inflammatory conditions other than TB, thereby determining whether or not said test subject has TB. | 2009-04-23 |
| 20090104603 | Tissue Carbohydrate Compositions and Analysis Thereof - The present invention reveals novel methods for producing novel carbohydrate compositions, glycomes, from animal tissues. The tissue substrate materials can be total tissue samples and fractionated tissue parts, or artificial models of tissues such as cultivated cell lines. The invention is further directed to the compositions and compositions produced by the methods according to the invention. The invention further represent methods for analysis of the glycomes, especially mass spectrometric methods. | 2009-04-23 |
| 20090104604 | SPERM-SPECIFIC CATION CHANNEL, CATSPER2, AND USES THEREFOR - Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders. | 2009-04-23 |
| 20090104605 | DIAGNOSIS OF SEPSIS - Methods and apparatus for predicting the development of sepsis in a subject at risk for developing sepsis are provided. Features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods and apparatus for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. A plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods and apparatus for diagnosing sepsis in a subject are provided. A plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set. | 2009-04-23 |
| 20090104606 | LATE GESTATION LUNG GENES, FRAGMENTS AND USES THEREOF - The present invention provides a family of genes related to late gestation lung genes and fragments thereof. Embodiments of the present invention provide compositions and methods for the therapeutic treatment of disorders in the lung or other tissues. More particularly the invention provides methods for the treatment of abnormalities in alveolarization, and abnormalities in branching morphogenesis. In other embodiments of the invention the use of the LGL1 gene or related products or fragments thereof in research and diagnostics is provided. | 2009-04-23 |
| 20090104607 | EUBACTERIAL tmRNA SEQUENCES AND USES THEREOF - The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays. | 2009-04-23 |
| 20090104608 | EUBACTERIAL tmRNA SEQUENCES AND USES THEREOF - The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays. | 2009-04-23 |
| 20090104609 | METHOD FOR DISCRIMINATION OF METAPLASIAS FROM NEOPLASTIC OR PRENEOPLASTIC LESIONS - The present invention relates to a method for discrimination of p16 | 2009-04-23 |
| 20090104610 | Real-Time Multiplex Detection of Three Bacterial Species Responsible for Sexually Transmitted Diseases - The invention relates to the detection of three different bacterial species which are responsible for sexually-transmitted diseases, i.e., | 2009-04-23 |
| 20090104611 | METHODS OF WHOLE GENOME ANALYSIS - Methods are provided for ascertaining the sequence of a genomic DNA sample by nicking the DNA sample with a restriction nicking enzyme, followed by nick translation with labeled nucleotides, such that the labeled nucleotides can be quantified and compared to a known, reference genome. | 2009-04-23 |
| 20090104612 | DETECTION OF BLOOD GROUP GENES - Disclosed herein are nucleic acid molecules which permit the accurate and direct determination of blood groups based on the presence of certain genes. A method of determining blood groups is also provided. | 2009-04-23 |
| 20090104613 | METHODS AND COMPOSITIONS RELATING TO MULTIPLEXED GENOMIC GAIN AND LOSS ASSAYS - Compositions and methods are provided for detecting genomic DNA gain and loss. Embodiments of inventive assays include using a substrate-attached composite nucleic acid probe which specifically hybridizes to two or more genomic loci in a genomic region of a reference genome. The genomic region is characterized by a first terminus and a second terminus and has an intermediate region disposed between the first terminus and second terminus of at least 400 kilobases. The composite nucleic acid probe includes nucleic acid sequences which specifically hybridize to substantially an entire first genomic locus including the first terminus and to substantially an entire second genomic locus including the second terminus. Methods and compositions are provided which include assessment of two or more genomic DNA references. | 2009-04-23 |
| 20090104614 | QUANTITATIVE MOLECULAR PROBES - In accordance with this invention, a molecular probe for detection of a nucleic acid target containing a preselected target sequence is constructed and has at least two sources of a signal: a conventional reporter source and a reference source in a form of a luminescent material, e.g., a fluorophore, quantum dot, fluorescent nanoparticle, or other fluorescent reference dye/nanoparticle/microparticle conjugated to the molecular probe. | 2009-04-23 |
| 20090104615 | PHENOTYPE PREDICTION - Detection of epigenetic alteration, especially methylation, of a gene or a combination of genes, preferably in a perinatal tissue sample such as umbilical cord, for predicting diverse phenotypic characteristics such as propensity for obesity, altered body composition, impaired cognition, low bone mineral content, neuro-behavioural problems and altered cardiovascular structure and function occurring in an individual. | 2009-04-23 |
| 20090104616 | PRIMER SET FOR AMPLIFYING SULT1A1 GENE, REAGENT FOR AMPLIFYING SULT1A1 GENE CONTAINING THE SAME, AND THE USES THEREOF - A primer set for amplifying a region including sites to be detected of SULT1A1*2 and SULT1A1*3 in the SULT1A1 gene by a gene amplification method is provided, wherein the primer set can amplify the region specifically. A pair of primer set is used including a forward primer consisting of the base sequence of SEQ ID NO: 7 as well as a reverse primer consisting of the base sequence of SEQ ID NO: 18. The use of this primer set makes it possible to specifically and efficiently amplify, a region including both sites where two types of polymorphisms (SULT1A1*2 and SULT1A1*3) of the SULT1A1 gene are generated. | 2009-04-23 |
| 20090104617 | Diagnostic and Prognostic Tests - The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from tissue samples, such as cancer tissue samples. The invention also provides sets of genes that are expressed differentially in malignant pleural mesothelioma. These sets of genes can be used to discriminate between normal and malignant tissues, and between classes of malignant tissues. Accordingly, diagnostic assays for classification of tumors, prediction of tumor outcome, selecting and monitoring treatment regimens and monitoring tumor progression/regression also are provided. | 2009-04-23 |
| 20090104618 | Psoriasin Expression By Breast Epithelial Cells - The invention features methods of diagnosing high grade ductal carcinoma in situ (DCIS) These methods involve measuring: (1) the level of HID-5 in a body fluid (e.g., blood or urine) of a subject suspected of having, or at risk of having, high grade DCIS; or (2) the level of HID-5 gene expression in breast tissue from a subject suspected of having, or at risk of having, high grade DCIS. The invention also embodies a method of inhibiting expression of HID-5 protein in DCIS cells and methods of treating a subject suspected of having, or at risk of having, high grade DCIS. | 2009-04-23 |
| 20090104619 | Human G-Protein Coupled Receptors - Two human G-Protein coupled receptor polypeptides and DNA (RNA) encoding each of such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the nucleic acid sequence of each of the G-protein coupled receptors. | 2009-04-23 |
| 20090104620 | Simplified Method of Determining Predisposition to Scoliosis - The present invention relates to novel genetic markers associated with scoliosis, risk of developing scoliosis and risk of scoliosis curve progression, and simplified methods and materials for determining whether a human subject has scoliosis, is at risk of developing scoliosis or is at risk of scoliosis curve progression. | 2009-04-23 |
| 20090104621 | METHOD FOR DETECTING A TARGET NUCLEIC ACID SEQUENCE - A method of detecting a target nucleic acid sequence comprising providing a stem-and-loop structured nucleic acid for measurement wherein the nucleic acid comprises complementary sequence portions located at both terminals and a target sequence portion therebetween as well as a double-stranded portion formed by hybridization of the complementary sequence portions located at both terminals and a remaining looped single-stranded portion, providing a probe nucleic acid having a sequence complementary to the target sequence portion wherein one end of the probe nucleic acid being immobilized to a solid substrate surface, reacting the nucleic acid for measurement with the probe nucleic acid to specifically hybridize the target sequence portion of the nucleic acid for measurement to the probe nucleic acid, and detecting presence or absence of the nucleic acid for measurement hybridized to the probe nucleic acid. | 2009-04-23 |
| 20090104622 | Extracellular/Epidermal Growth Factor Like Protein - The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention. | 2009-04-23 |
| 20090104623 | COMPOSITIONS FOR CONTROLLING HAIR GROWTH - FP-1 is a protein that is specifically expressed in the follicular papilla of the hair follicle. The nucleic acid and amino acid sequences of FP-1, as well as antibodies that specifically bind FP-1 are provided. In addition, methods of isolating follicular papilla cells and methods of modulating hair growth are also disclosed. | 2009-04-23 |
| 20090104624 | METHODS AND KITS FOR DETECTING ITA IN A BIOLOGICAL SAMPLE - Methods for detecting invasive trophoblast antigen (ITA) in biological samples comprise screening the samples for ITA using antibodies that bind to the ITA. The methods are useful to detect pregnancy, trophoblastic diseases, and Down's syndrome in fetuses of pregnant women. Some methods include screening the samples with a plurality of capture antibodies that specifically bind ITA. Chemiluminescent immunoassays are disclosed. The methods may be practiced with the diagnostic kits of the invention. | 2009-04-23 |
| 20090104625 | Homogeneous immunoassays for multiple allergens - A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels. | 2009-04-23 |
| 20090104626 | METHODS OF ISOLATING BIPOTENT HEPATIC PROGENITOR CELLS - A method of obtaining a mixture of cells enriched in hepatic progenitors is developed which comprises methods yielding suspensions of a mixture of cell types, and selecting those cells that are classical MHC class I antigen(s) negative and ICAM-1 antigen positive. The weak or dull expression of nonclassical MHC class I antigen(s) can be used for further enrichment of hepatic progenitors. Furthermore, the progenitors can be selected to have a level of side scatter, a measure of granularity or cytoplasmic droplets, that is higher than that in non-parenchymal cells, such as hemopoietic cells, and lower than that in mature parenchymal cells, such as hepatocytes. Furthermore, the progeny of the isolated progenitors can express alpha-fetoprotein and/or albumin and/or CK19. The hepatic progenitors, so isolated, can grow clonally, that is an entire population of progeny can be derived from one cell. The clones of progenitors have a growth pattern in culture of piled-up aggregates or clusters. These methods of isolating the hepatic progenitors are applicable to any vertebrates including human. The hepatic progenitor cell population is expected to be useful for cell therapies, for bioartificial livers, for gene therapies, for vaccine development, and for myriad toxicological, pharmacological, and pharmaceutical programs and investigations. | 2009-04-23 |
| 20090104627 | METHOD FOR DETERMINATION OF ENZYMATIC ACTIVITY - A novel modified polysaccharide, a solid phase to which the polysaccharide is adhered, methods for detecting N-deacetylase activity, N-sulfotransferase activity and N-deacetylase/N-sulfotransferase activity in a sample which utilizes said solid phase, and detection kits thereof. | 2009-04-23 |
| 20090104628 | Method for quantifying phosphokinase activity on proteins - The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those sites. The method involves the in vitro or in vivo phosphorylation of a target protein at a specific serine, threonine or tyrosine residue, subjecting that protein (non-phosphorylated) to reaction mixture containing all reagents, including phosphokinase which allow the creation of a phosphorylated form of protein. The phosphorylated protein is measured by contacting it with an antibody specific for the phosphorylation site(s). The invention includes antibodies useful in practicing the methods of the invention. The invention particularly relates to all proteins modified by phosphorylation and dephosphorylation as illustrated by Tau, Rb and EGFR proteins and antibodies specific for the site of phosphorylation of the Tau, Rb or EGFR proteins. | 2009-04-23 |
| 20090104629 | USE OF BIOMARKERS OF ALZHEIMER'S DISEASE FOR DIAGNOSTIC TESTS AND DRUG SCREENING - The invention relates to method of diagnosing Alzheimer's disease or detecting a predisposition to Alzheimer's disease including providing a test cell sample from a subject, exposing the test cell sample to labeled amyloid beta peptides, and determining the level of labeled amyloid beta peptides in the test cell sample, wherein lower levels of labeled amyloid beta peptides in the test cell sample compared to a control cell sample are indicative of Alzheimer's disease. | 2009-04-23 |
| 20090104630 | Semi-quantitative immunochromatographic device and method for the determination of HIV/AIDS immune-status via measurement of soluble CD40 ligand/CD 154, A CD4+T cell equivalent - A semi-quantitative, immunochromatographic device for the detection of HIV/AIDS immune status CD4+ T cell equivalents, such as soluble CD40 ligand/CD 154, includes one or more support materials capable of providing lateral flow. The one or more support materials include a first area for receiving a biological sample containing a target analyte, the analyte being a CD4+ T cell equivalent, such as soluble CD40 ligand/CD 154, a second area having a movably contained detector ligand, wherein the detector ligand is capable of forming a mobile complex with the soluble CD40 ligand/CD 154, and at least one capture area having a predetermined amount of an immobile capture reagent, the immobile capture reagent capable of specifically binding to the mobile complex formed by the soluble CD40 ligand/CD 154 protein and the detector ligand and providing a visible signal. | 2009-04-23 |
| 20090104631 | PSCA: PROSTATE STEM CELL ANTIGEN AND USES THEREOF - The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors. | 2009-04-23 |
| 20090104632 | MODIFIED TWO-STEP IMMUNOASSAY EXHIBITING INCREASED SENSITIVITY - The present invention relates to immunoassays for detecting or quantifying at least one analyte of interest in a test sample which exhibits improved sensitivity and/or a reduction in non-specific background compared to the immunoassay formats known in the art. | 2009-04-23 |
| 20090104633 | Kit for Highly Sensitive Detection Assays - The present invention relates to kits comprising 2,4-dichlorophenoxyacetate derivatives as well as antibodies that bind to these derivatives. Inter alia, the kits can be used to label biomolecules for analytical and diagnostic applications. Some of the compounds described here can be used to label biomolecules under physiological conditions and without having to apply in situ activation. Furthermore, the presence of spacers within the 2,4-dichlorophenoxyacetate derivatives improves their binding to antibodies. | 2009-04-23 |
| 20090104634 | ONE-STEP IMMUNOASSAYS EXHIBITING INCREASED SENSITIVITY AND SPECIFICITY - The present disclosure relates to immunoassays for detecting or quantifying at least one analyte of interest in a test sample which exhibits improved sensitivity and specificity compared to the immunoassay formats known in the art. | 2009-04-23 |
| 20090104635 | Fluorescent Dry Test Strip Biosensor - Disclosed herein is a dry fluorescence biosensor strip for rapid detection of a target analyte present in bodily fluids. The dry fluorescence biosensor strip comprises a sample receptacle and a dry detection membrane. The sample receptacle receives a sample of one of the bodily fluids. The dry detection membrane detects presence of the target analyte in the received sample based on fluorescence induced on the dry detection membrane. Fluorescent signals are emitted from the dry detection membrane on induction of fluorescence. A fluorometer quantifies measurable properties of the target analyte based on the emitted fluorescent signals. The dry fluorescence biosensor strip may further comprise a filtration membrane for filtering the received sample. The filtered sample migrates from the filtration membrane to the dry detection membrane. The dry detection membrane may then detect presence of the target analyte in the filtered sample. | 2009-04-23 |
| 20090104636 | QUANTITATIVE ANALYSIS OF A BIOLOGICAL SAMPLE OF UNKNOWN QUANTITY - Disclosed is a method for testing a modified specimen such as a dried blood spot, plasma or serum specimen, for an analyte of interest, such as cholesterol. In accordance with the disclosed subject matter, the level of the analyte of interest in the medium from which the modified specimen was obtained (e.g., from a patient's blood) is determined based on the level of an analyte in a solution formed from the modified specimen and on the level of at least one normalizing analyte. The analyte and normalizing analyte each may be an ion, compound, biochemical entity, or property of the specimen. Also disclosed are a fluid collector and a fluid collection device. | 2009-04-23 |
| 20090104637 | Method and Apparatus for Assaying Blood Clotting - This invention provides an apparatus for assaying clotting activity. The apparatus includes an inlet for a blood fluid and two or more patches of material in the vessel. The material is capable of initiating a clotting pathway in a blood fluid. This invention also provides an apparatus for measuring clot propagation, which includes a region with material capable of initiating a clotting pathway, and a region where the clot propagation is monitored. Also provided are methods for assaying clotting activity, assaying the integrity of a blood clotting pathway, assaying the effect of a substance on the integrity of a blood clotting pathway, monitoring clot propagation, and preventing clot propagation from one vessel to another. | 2009-04-23 |
| 20090104638 | Methods for Building Atomic Models of Protein Molecules and Determining Drug Candidates Using MGST1 - Methods for building an atomic model of a protein molecule comprising: (a) identifying a protein molecule with at least 20% sequence identity with Microsomal Glutathione Transferase 1 (MGST1) and (b) utilizing the atomic coordinates of MGST1 to obtain an atomic model of the identified protein molecule and methods for determining a drug candidate compound that interacts with members of the MAPEG superfamily, in particular MGST1 are also provided. | 2009-04-23 |
| 20090104639 | BIOMARKERS FOR MOTOR NEURON DISEASE - The invention provides methods of determining a diagnosis or prognosis of motor neuron disease in a mammal comprising determining the expression level of one or more proteins or polypeptides of the renin-angiotensin system in a sample taken from a subject. Similarly, aberrant post-translational modification of the proteins or polypeptides as compared to a negative control indicates a diagnosis of disease. | 2009-04-23 |
| 20090104640 | Method of Evaluating Biological Material and Bioreactor Therefor - A method of evaluating biological material comprising forming a 3-dimensional scaffold of tubular biological material, delivering a fluid through the tubular biological material, and evaluating the biological material and in particular evaluating the effect of biomolecules, medical devices and medical devices containing biomolecules on biological material. The invention further relates to a bioreactor suitable for evaluating biological material. | 2009-04-23 |
| 20090104641 | Electrochemical method for detecting hemoglobin or hematocrit and test strip thereof - The present invention provides an electrochemical method and a test strip for detecting hemoglobin in a specimen. The method includes the steps of providing the specimen with a reagent, which has a buffer solution, a surfactant and an electron mediator, tetrathiafulvalene, modified by cyclodextrin; detecting electric current produced by the reaction of the hemoglobin and the electron mediator in a specimen under a potentiostatic condition; and calculating a hemoglobin concentration in the specimen according to the detected electric current. In the method of the present invention, tetrathiafulvalene modified by cyclodextrin is used as an electron mediator, which directly interacts with the hemoglobin in the specimen. Since the hemoglobin concentration is in inverse proportion to the value of electric current or the value of SOC (state-of-charge) integrated by electric current value with time, the hemoglobin concentration in a whole blood specimen or the hematocrit level in a blood specimen is accurately and rapidly obtained according to the detected electric value or the value of SOC. | 2009-04-23 |
| 20090104642 | NOVEL UBIQUITIN LIGASES AS THERAPEUTIC TARGETS - The present invention relates to the discovery and characterization of activity of Fbp1, a substrate-targeting ubiquitin ligase subunit. The invention encompasses interactions between Fbp1 and its substrates, including Fbp5, β-Catenin, and IκBα. The invention also encompasses interactions between the Fbp1 isoform β-Trcp2 and its substrates, including Fbp5, b-Catenin, and IκBα. The present invention relates to screening assays that use Fbp1 and/or β-Trcp2 to identify potential therapeutic agents such as small molecules, compounds or derivatives which modulate Fbp1 and/or β-Trcp2 activity for the treatment of proliferative and differentiative disorders, including infertility, cancer, major opportunistic infections, immune disorders, certain cardiovascular diseases, and inflammatory disorders. The invention also encompasses methods to diagnose and treat Fbp1-related infertility disorders. The invention further encompasses therapeutic protocols and pharmaceutical compositions designed to target Fbp1 and its substrates for the treatment of infertility. | 2009-04-23 |
| 20090104643 | BIOLUMINESCENCE-BASED SENSOR WITH CENTRIFUGAL SEPARATION AND ENHANCED LIGHT COLLECTION - In general, embodiments of the present invention relate to a bioluminescence-based point of care device that is made up of at least one reaction well ( | 2009-04-23 |
| 20090104644 | GENETICALLY MODIFIED CYCLIC-NUCLEOTIDE CONTROLLED ION CHAN - A genetically modified cyclic-nucleotide controlled ion channels where the subunits thereof are altered in such a manner that they have a higher sensitivity for cAMP in relation to cGMP in comparison with the Wildtype according to Seq ID No. 1 and 2. | 2009-04-23 |
| 20090104645 | Vectors And Methods For Identifying Proteins Amenable To Crystallization - The present invention provides for methods, systems and materials that may be used to identify and select proteins that are amenable to crystallization. While previous methods of screening proteins for crystallization required at least microgram quantities of purified protein, the inventive method can be practiced using nanogram quantities of unpurified protein. | 2009-04-23 |
| 20090104646 | Antibodies And Methods For Generating Genetically Altered Antibodies With Enhanced Effector Function - Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. These methods are useful for generating genetic diversity within immunoglobulin genes directed against an antigen of interest to produce altered antibodies with enhanced biochemical activity. Moreover, these methods are useful for generating antibody-producing cells with increased level of antibody production. The invention also provides methods for increasing the effector function of monoclonal antibodies and monoclonal antibodies with increased effector function. | 2009-04-23 |
| 20090104647 | METHODS FOR SELECTING ACTIVE AGENTS FOR CANCER TREATMENT - The present invention provides methods for individualizing chemotherapy, and particularly methods for individualizing neoadjuvant chemotherapy. The present invention provides methods for predicting a cancer patient's response to neoadjuvant chemotherapy, including assessing the probability of a positive response upon treatment with candidate agents prior to surgery. In various aspects, the invention involves culturing a monolayer of malignant cells from an explant of a patient's biopsy specimen, such as a transcutaneous biopsy-sized specimen, and testing the malignant cells for resistance or sensitivity to one or a plurality of candidate agents for neoadjuvant therapy. In other aspects, the invention provides methods for accurately scoring and interpreting such assays, and discloses in vitro chemoresponse results that are predictive of a patient's pathological complete response (pCR) upon receiving the corresponding treatment regimen. | 2009-04-23 |
| 20090104648 | TRANSFORMED CELL WITH ENHANCED SENSITIVITY TO ANTIFUNGAL COMPOUND AND USE THEREOF - The present invention provides a transformed cell in which a polynucleotide having a nucleotide sequence encoding an amino acid sequence of an osmosensing histidine kinase having no transmembrane region is introduced in a functional form into a cell deficient in at least one hybrid-sensor kinase, a method of assaying the antifungal activity of a test substance using the transformed cell, and a method of searching an antifungal compound using the method, and the like. | 2009-04-23 |
| 20090104649 | MARKERS FOR PREECLAMPSIA - This document provides methods and materials related to determining whether or not a pregnant mammal (e.g., a pregnant human) has preeclampsia. For example, methods and materials related to the use of urinary podocytes to determine whether or not a pregnant human has preeclampsia are provided. | 2009-04-23 |
| 20090104650 | Infectious diseases testing of menstrual fluid, endometrial/menstrual cells, amniotic fluid, umbilical cord blood or other samples - Methods are provided for obtaining and testing or analyzing a non-venous and non-arterial puncture human fluid or cell sample or human body fluid or cell sample to detect the presence of at least one infectious disease. The sample may be menstrual fluid, endometrial menstrual cells, umbilical cord blood, or amniotic fluid. Confirmatory testing of a corresponding arterial or venous blood sample for comparison to the test results for the non-venous and non-arterial human fluid or cell sample may be performed. The testing may comprise a screening test or a confirmatory test. | 2009-04-23 |
| 20090104651 | SCREENING PROCESS FOR ANTIBACTERIAL AGENTS - The present invention relates to a method of preparing a phenotypically antibiotic-resistant subpopulation of stationary phase bacteria by treating stationary phase bacteria with high doses of antibacterial agents, the subpopulation thus identified, a process for identifying new antibacterial agents by testing against the antibiotic-resistant subpopulation, the compounds thus identified and their uses, particularly in treating bacterial infections involving dormant bacteria. | 2009-04-23 |
| 20090104652 | METHOD AND APPARATUS FOR VIABLE AND NONVIABLE PROKARYOTIC AND EUKARYOTIC CELL QUANTITATION - A rapid method for the quantitation of various live cell types is described. This new cell fluorescence method correlates with other methods of enumerating cells such as the standard plate count, the methylene blue method and the slide viability technique. The method is particularly useful in several applications such as: a) quantitating bacteria in milk, yogurt, cheese, meat and other foods, b) quantitating yeast cells in brewing, fermentation and bread making, c) quantitating mammalian cells in research, food and clinical settings. The method is especially useful when both total and viable cell counts are required such as in the brewing industry. The method can also be employed to determine the metabolic activity of cells in a sample. The apparatus, device, and/or system used for cell quantitation is also disclosed. | 2009-04-23 |
| 20090104653 | Bio-process model predictions from optical loss measurements - This invention relates to methods for monitoring and controlling bioprocesses. Specifically, it describes using quasi-real-time analytical and numerical techniques to analyze optical loss measurements calibrated to indicate cell viability, whereby it is possible to reveal process changes and/or process events such as feeding or induction. Additionally, the present invention makes it possible to accurately estimate the onset of a decrease in cell viability and/or a suitable time for cell harvesting for a cell culture growth process. Pattern recognition methods for identifying specific process events such as batch feeding, cell infection, and product precipitation are also described. | 2009-04-23 |
| 20090104654 | LOW VOLATILITY HIGH TEMPERATURE TISSUE CONDITIONING CROSS-REFERENCE TO RELATED APPLICATION - Solutions exhibiting little or no evaporative loss at elevated temperatures, i.e., in excess of 100° C., are employed in place of conventional aqueous-based antigen retrieval solutions. | 2009-04-23 |
| 20090104655 | Fermentation Method and Apparatus for its Implementation - In order to develop and optimize metering strategies for fed-batch fermentations in two or more reaction vessels, release systems containing nutrients are attached to the inner surfaces of the reaction vessels in areas that will come into contact with culture liquid placed in the vessels. | 2009-04-23 |
| 20090104656 | System for the Inducible Expression of Recombinant Proteins in Cyanobacteria - The invention relates to a system for inducible expression in cyanobacteria, which enables the expression of recombinant proteins, and to the vectors and cyanobacteria containing said expression system. | 2009-04-23 |
