16th week of 2010 patent applcation highlights part 6 |
Patent application number | Title | Published |
20100099056 | METHOD AND APPARATUS FOR OCCLUSAL POSITION MEASUREMENT AND RECORDING - The occlusal position of a patient is measured by means of light transmission through a layer of a polysiloxane which is not cross-linked. This material forms an exceptionally accurate impression of a patient's bite essentially instantaneously and enables subsequent recording and analysis of the bite in a matter of minutes. | 2010-04-22 |
20100099057 | ROOT CANAL INSTRUMENT HANDLE MADE OF TWO CO-AXIAL PORTIONS JOINED IN AXIAL TRANSLATION AND IN ROTATION - The invention relates to a method for designing and producing a package intended for the protection and/or transportation of a product. All of the digital design steps for the package are integrated in the method for digitizing the product, which includes a step of laminating a virtual key form of the product used to define geometrical data of each layer of the package to be cut. Then, the cutting is carried out followed by the stacking of the layers of the package defined by the design steps for said package to form a real package. The invention also relates to the package obtained by the method. | 2010-04-22 |
20100099058 | Method of Dental Implant Restoration - The invention provides a method for dental restoration including direct modification of an abutment in the oral environment to obtain the ideal shape, contour, and margin placement. The method is featured with directly measuring the shortest distance X | 2010-04-22 |
20100099059 | GUN SIMULATOR - The chain gun simulator provides a high-fidelity simulation of the electrical control system signals for any weapon platform using a variety of chain gun types. The simulator device is stand-alone, requiring no external equipment, and replicates the electrical states, levels, and timing of the real guns such that the weapon platform's fire control interface can function normally without the need for a real gun and live ammunition. In addition, the simulator provides user control for selecting gun type and mode, and provides visual indication of modes, feed selection, and simulated weapon bolt position. There may also be an audible indication every time the simulator has advanced through the normal shutdown portion of the gun cycle. | 2010-04-22 |
20100099060 | SALES RESPONSE TRAINING SYSTEM AND METHODS - Embodiments of the invention describe the implementation and execution of situational response training (SRT). In some embodiments, a sales team can use an SRT to implement real-time, peer-reviewed and/or focused training. For example, a manager can prepare a training situation through a web interface and then verbally record the training through a telephone interface. The training situation can include any number of questions, scenarios, fact patterns, etc. that can require a response by members of the sales team. Once prepared, the manager can send the training situation to his sales team. The sales team can then prepare and respond to the training situation over the phone using an interactive voice response (IVR) system or through another communication channel. For example, the training situation can be sent via email requesting that each member of the sales team respond to the training situation through a telephone interface. | 2010-04-22 |
20100099061 | ALPHANUMERIC FONT FOR THE BLIND AND VISUALLY IMPAIRED - A tactile alphanumeric font includes raised alphabetic symbols representing the letters of the Roman alphabet and raised numeric symbols representing the Arabic numerals. The alphabetic symbols are divided into first-fourth regions, the alphabetic symbols in the first and third regions being denoted by a circular frame, and the alphabetic symbols in the second and fourth regions being denoted by a square frame. Uppercase symbols are designated by a dot centrally located above the lowercase symbol frame. The numeric symbols are denoted by a pentagonal frame. All of the frames have an aspect ratio of less than or equal to approximately 1.25. At least some of the alphabet and numeric symbols also include an interior element inside of and separated from the frame; and at least some of the alphabet and numeric symbols embody at least a physical association, such as a dominant characteristic, of their corresponding letter of the Roman alphabet or corresponding Arabic numeral 0-9. | 2010-04-22 |
20100099062 | Braille Cell Cap - An electromechanical Braille cell assembly includes a plurality of parallel bimorph reeds. A first plurality of bimorph reeds is mounted to a first side of a printed circuit board by a first plurality of clips and a second plurality of bimorph reeds is mounted to a second side of the printed circuit board by a second plurality of clips. A frame has a top wall, a bottom wall, a first side wall in the form of an angle wall and a second side wall in the form of a flat wall. Pinholes are formed in the angle wall to accommodate Braille pins and the flat wall is slotted to accommodate a plurality of printed circuit boards. A monolithic cap covers all of the Braille pins. Pinholes formed in the cap receive the respective tips of the Braille cells when actuated bimorph reeds cause displacement of the Braille pins. | 2010-04-22 |
20100099063 | WAGERING GAME EDUCATIONAL SYSTEM - A computerized wagering game education system includes presentation of one or more interactive wagering game technical tasks to a student, presentation of a quiz to a student via the network interface such that the quiz results are used to provide suggestions for further study, and presenting multiple levels of testing to a student as part of a certification process, comprising at least one quiz presented after the completion of at least one course and at least one certification test presented at the completion of multiple courses. | 2010-04-22 |
20100099064 | COLLECTIBLE CENTRIC EDUCATIONAL GAME SYSTEM - Children exhibit curiosity and desire to acquire things of interest from their earliest stages. This eventually evolves into their lust for toys, dolls, stickers, books, clothing, having books read to them, being allowed to watch TV, and more. Things of a child's interest are generically referred to as ‘collectibles’ hereafter. A game system that overlays educational content with in-game collectibles is presented. The more in-game collectibles the player has the more fun they have. This paradigm converts the lust for in-game collectibles into a lust to learn. A virtuous cycle emerges where (i) anticipation to acquire the next educational content builds up, and then (ii) this anticipation is gratified when the educational content is finally acquired, and (iii) the educational content is naturally appreciated until the child moves onto the next collectible. | 2010-04-22 |
20100099065 | INTERACTIVE CINEMATIC SYSTEM FOR BONUS FEATURES FOR MOVIES, TV CONTENTS, ANIME AND CARTOONS, MUSIC VIDEOS, LANGUAGE TRAINING, ENTERTAINMENT AND SOCIAL NETWORKING - This invention is an apparatus and a method for language training and general entertainment and role-playing. It employs a digital processing system that can play back audio or audio-visual program material, using special software to selectively direct the audio of this playback through the digital processing system's speaker system or through a headset, with the user taking the audio routed to her headset—in particular speech—as a model and prompt to repeat this speech audibly. The user plays the role of the person in the program material whose speech is being routed to her headset, and the special software further permits the user to record her dubbing efforts along with the program material, producing a version of the program material with the user's voice recorded in place of, or in conjunction with, the voice of a character in the program material. | 2010-04-22 |
20100099066 | Surgical Training System and Model With Simulated Neural Responses and Elements - A training apparatus, model, system, and method are disclosed that allows any trainee to train to perform surgeries in areas of the human body that include one or more nerves. The training model is configured to mimic one or more areas of the human anatomy in which the procedure is going to be performed that contains nerves by providing a realistic anatomical model of the area of interest. A neural element is positioned in the anatomical area of interest that is configured to behave like a real nerve. A neural monitoring system is utilized to ensure that while using specially designed surgical tools or devices during the procedure, the surgeon is trained to avoid taking actions that would adversely affect the functionality of the nerves located in this area after the surgery. | 2010-04-22 |
20100099067 | Mannequin for Medical Training - A mannequin representing a human body, anatomically particularized, adult aged and real sized with real motions. Special care is posed in selecting the materials in order to resemble the natural texture of human tissues. The aim of the mannequin is to allow the acquisition of medical skills in the field of pain management (peripheral anaesthesia techniques, vessels cannulation, port-a-cath implantation) through interchangeable modules simulating a plurality of anatomical variabilities (“drawers”). | 2010-04-22 |
20100099068 | ITEM MANAGEMENT SYSTEM - The present subject matter relates to a system for generating documents for testing and surveys. The system in various embodiments provides for generating and managing an electronic item bank The system provides for generation, administration, analyses, and processing of tests and surveys formed from items in the item bank Wherein an item includes information stored in a data structure to serve as a common source for the information for that particular item. | 2010-04-22 |
20100099069 | METHOD FOR VERIFYING ANSWERS INPUT INTO A QUIZ COMPUTER - The invention relates to a method for verifying answers of a quiz game that are input into a quiz computer, which comprises an input keyboard, an OK key, a display and a computer unit that is equipped with a read-only memory unit containing an operating program, said operating program coding for a method for evaluating answers input by means of the input keyboard during a quiz game, said operating program coding for the generation of control and/or confirmation data from input answers, said operating program coding for at least one security feature from the group consisting of the generation of a device time initialized by the actuation of a key, the generation of a random data word upon actuation of a key, and the combinations of the prominent security features, and said security feature in addition to the control and/or confirmation data being transmitted to a game organizer and verified at that location, and a program coding for such a method and a quiz computer for carrying-out such a method. | 2010-04-22 |
20100099070 | METHOD AND APPARATUS FOR AGGREGATING, PRESENTING, AND MANIPULATING DATA FOR INSTRUCTIONAL PURPOSES - A method and apparatus for aggregating data for instructional purposes. The method includes retrieving student responses, determining at least one bucket type and, if needed, changing the algorithmic criteria defining the at least one bucket type, aggregating the responses according to bucket type, and utilizing the aggregated responses for instructional purposes. | 2010-04-22 |
20100099071 | METHOD AND APPARATUS FOR AGGREGATING, ANALYZING, PRESENTING, AND MANIPULATING PROCESS DATA FOR INSTRUCTIONAL PURPOSES - A method and apparatus for presenting aggregated data for instructional purposes. The method includes retrieving student responses, determining at least one bucket type and, if needed, changing the algorithmic criteria defining the at least one bucket type, aggregating the responses according to bucket type, viewing students responses in the aggregated format, wherein the responses are displayed step by step to show the process of arriving to the response, and comparing at least two students responses to each other. | 2010-04-22 |
20100099072 | METHOD AND APPARATUS FOR PRESENTING AGGREGATED DATA FOR INSTRUCTIONAL PURPOSES - A method and apparatus for presenting aggregated data for instructional purposes. The method includes retrieving student responses, determining at least one bucket type and, if needed, changing the algorithmic criteria defining the at least one bucket type, aggregating the responses according to bucket type; and utilizing the aggregated responses to view or present at least one response in a different representation. | 2010-04-22 |
20100099073 | Combination chalkboard and corkboard - The combination chalkboard and corkboard is a display, both for erasable writing thereon with chalk and for removable attachment thereto of paper and the like via pushpins or thumbtacks. The combination chalkboard and corkboard includes a frame, a cork layer, and a mesh layer. The cork and mesh layers may be held together by the frame. The mesh layer is at least partially exposed through the frame so that the mesh may be marked by chalk. Apertures formed through the mesh layer and the cork layer are adapted for receiving pushpins. | 2010-04-22 |
20100099074 | COLLECTION DEVICE AND METHOD FOR STIMULATING AND STABILIZING A BIOLOGICAL SAMPLE - A collection device and methods for stimulating and stabilizing a biological sample are provided. Aspects of the device include an evacuated sample collection container having stimulating and stabilizing additives contained in separate internal chambers of the container. The internal chambers are arranged to facilitate stimulation upon collection of a sample, followed by stabilization of the sample after a desired period of time in the same sealed container. Also provided are methods for use of the subject device. The device and methods find use in a variety of different applications, including the collection and analysis of clinically relevant samples, such as whole blood and other body fluids, obtained directly from a patient. | 2010-04-22 |
20100099076 | SENSITIVE AND RAPID DETECTION OF VIRAL PARTICLES IN EARLY VIRAL INFECTION BY LASER TWEEZERS - The present system and methods allow for low level detection of as little as single pathogen particles, such as viral or bacterial particles, during the early stage of infection. An optical trapping system, such as laser tweezers, are used to trap a substrate to which an analyte has been bound to detect and record the thermal motion of an antibody-antigen interaction that may occur between an anti-viral antibody-coated microsphere and a viral particle for example. The system may be equipped with a detection system such as a position sensitive photodetector (PSD) to record the thermal motion of a trapped microsphere and particle at a certain frequency. The thermal motion data may be Fourier transformed into a power spectrum, which may be transformed into an output value using a Lorentzian equation. The power spectrum of the trapped microsphere may be recorded before and after binding of the pathogenic particle to determine the presence thereof. | 2010-04-22 |
20100099077 | STABLE ACRIDINIUM ESTERS WITH FAST LIGHT EMISSION - Chemiluminescent acridinium esters are provided which are fast light emitting and hydrolytically stable. The chemiluminescent acridinium esters are useful labels in assays for detecting or quantifying analytes. | 2010-04-22 |
20100099078 | METHOD FOR DESIGNING A DRUG REGIME FOR HIV-INFECTED PATIENTS - The instant disclosure describes a novel genotype and phenotype assay to elucidate and/or evaluate new potential HIV integrase inhibitors, but also currently approved and experimental compounds that target protease, reverse transcriptase, and RNaseH. This assay allows studying linked mutations and mutational patterns that occur under HAART and experimental therapies. | 2010-04-22 |
20100099079 | Non-dividing cell-based assay for high throughput antiviral compound screening - The present invention features a cell-based assay that recapitulates all aspects of a viral lifecycle for use in identifying antiviral agents. The assay employs synchronized, non-dividing host cells and a fluorescence resonance energy transfer peptide substrate for monitoring endogenous viral protease activity, which is indicative of viral infection kinetics. | 2010-04-22 |
20100099080 | NUCLEIC ACID MEMORY DEVICE - This invention pertains to methods of imparting information onto nucleic acid sequences. In specific embodiments, the present invention provides site-specific recombinase systems and error-prone polymerase systems to alter nucleotide sequences such as DNA and mini-genomes, as well as for the production of microarrays. The present invention also provides methods of analyzing the modified nucleotides sequences provided herein. Methods of engineering and screening for novel modified polymerases that incorporate chain terminating nucleotides and/or labeled nucleotides more efficiently than wild-type polymerases are also provided. | 2010-04-22 |
20100099081 | Method for Typing HLA Alleles - The present invention relates to the typing of HLA alleles. The sequence of exon 2 and exon 3 of the alleles HLA-B*3913, HLA-B*1406 and HLA-B*51 new and of exon 2 of the alleles HLA-DRB1*0820, HLA-DRB1*04 new and HLA-DRB4*01 new are disclosed. The present invention relates to methods for typing of said alleles. According to a preferred embodiment, said typing comprises the following steps: i) amplifying a relevant fragment of said alleles using at least one suitable pair of primers; ii) hybridizing the amplification product of step i) to at least one probe that specifically hybridizes to a target region comprising one or more polymorphic nucleotides in said relevant fragment; iii) determining from the result of step ii) the absence or presence of said alleles in the sample. The present invention further provides primers and probes to be used in said methods for typing. A diagnostic kit comprising said primers and probes is also part of the present invention. | 2010-04-22 |
20100099082 | Allele Detection - Method for simultaneously determining alleles present in a set of loci from at least one nucleic acid sample comprising the steps: a) providing said at least one sample, b) subjecting said sample to a nucleic acid amplification reaction using a primer pair simultaneously primer pairs specific and optimized for each of the loci of a set of at least three loci selected from the group consisting of D2S1360, D7S1517, D8S1132, D9S1118, D10S2325, D11S554, D12S1064, D12S391, D17S1290, D19S253, MYCLl, P450CYP19 and SE-33, and c) evaluating the length and optionally the relative quantity of amplification products obtained from step b) or from the analysis of one or two of the above loci to determine and/or optionally quantify the alleles present at each of the loci analyzed in the set within said sample. | 2010-04-22 |
20100099083 | CROHN DISEASE SUSCEPTIBILITY GENE - The present invention relates to the ATG16l1 gene and genetic variants associated with Crohn's disease. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to Crohn's disease and/or their response to a particular drug or drugs. | 2010-04-22 |
20100099084 | DETECTION OF NPM1 NUCLEIC ACID IN ACELLULAR BODY FLUIDS - The present inventions relates to methods for detecting NPM1 nucleic acid in acellular body fluid samples and determining whether the nucleic acid contains one or more mutations including insertions and deletions. The methods are useful for predicting prognosis of AML patients that have cells with mutations in the NPM1 gene. | 2010-04-22 |
20100099085 | Serum DNA Methylation Screening for Cancer - We disclose a method of screening a mammal for a cancer associated with methylation of promoters of tumor-suppressor genes by collecting a sample of a body fluid or tissue of the mammal containing free DNA; isolating the free DNA from the sample; amplifying at least a portion of the promoter of each of a plurality of turner-suppressor genes associated with the cancer from the free DNA, to yield a plurality of amplified promoters; and quantifying methylation of each of the plurality of amplified promoters, to yield a methylation quantity. The method can have a high sensitivity and high specificity and can thus reduce the proportion of unneeded biopsies. It can also be performed with minimal invasiveness and discomfort to a patient. | 2010-04-22 |
20100099086 | Method and apparatus for determining a probability of colorectal cancer in a subject - A method of determining a probability that a human test subject has colorectal cancer as opposed to not having colorectal cancer is disclosed. The method comprises, for each gene of a set of one or more genes selected from the group consisting of ANXA3, CLEC4D, IL2RB, LMNB1, PRRG4, TNFAIP6 and VNN1: determining a level of RNA encoded by the gene in blood of the test subject, thereby generating test data; providing positive control data representing levels of RNA encoded by the gene in blood of human control subjects having colorectal cancer, and providing negative control data representing levels of RNA encoded by the gene in blood of human control subjects not having colorectal cancer; and determining a probability that the test data corresponds to the positive control data and not to the negative control data, where the probability that the test data corresponds to the positive control data and not to the negative control data represents the probability that the test subject has colorectal cancer as opposed to not having colorectal cancer. | 2010-04-22 |
20100099087 | GENE SEQUENCE VARIANCES IN GENES RELATED TO FOLATE METABOLISM HAVING UTILITY IN DETERMINING THE TREATMENT OF DISEASE - The present disclosure describes the use of genetic variance information for folate transport or metabolism genes or pyrimidine transport or metabolism genes in the selection of effective methods of treatment of a disease or condition. The variance information is indicative of the expected response of a patient to a method of treatment. Methods of determining relevant variance information and additional methods of using such variance information are also described. | 2010-04-22 |
20100099088 | RELIABLE DETECTION OF VANCOMYCIN-INTERMEDIATE STAPHYLOCOCCUS AUREUS - The present invention relates to a method for identifying a VISA strain in a sample comprising measuring SAV2095 expression levels, a kit and use of SAV2095 for same. The present invention also relates to a method for facilitating the development of an individualized treatment regimen comprising measuring the expression level of SAV2095. The present invention further relates to a method for monitoring the progression of a vancomycin treatment of an infection comprising measuring the expression level of SAV2095. The present invention also relates to the detection of | 2010-04-22 |
20100099089 | REPORTER UNIT FOR DETECTION OF TARGET MOLECULES USING POLYMERISABLE SUBSTRATE - The invention relates to a reporter unit for detecting a target molecule comprising at least one component attached to a target molecule specific probe, wherein said at least one component is liberated from said probe by the activity of a first enzyme thereby making the at least one component available as a substrate for a second enzyme which employs the substrate in a polymerization reaction to obtain a detectable structure. | 2010-04-22 |
20100099090 | BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO CTLA-4 ANTAGONISTS - CTLA-4 biomarkers useful in a method for predicting the likelihood that a mammal that will respond therapeutically to a method of treating cancer comprising administering an CTLA-4 antagonist, wherein the method comprises (a) measuring in the mammal the level of at least one biomarker s, (b) exposing a biological sample from the mammal to the CTLA-4 antagonist, and (c) following the exposing of step (b), measuring in the biological sample the level of the at least one biomarker, wherein an increase in the level of the at least one biomarker measured in step (c) compared to the level of the at least one biomarker measured in step (a) indicates an increased likelihood that the mammal will respond therapeutically to the method of treating cancer. | 2010-04-22 |
20100099091 | GENETIC COMPONENT OF COMPLICATIONS IN TYPE 2 DIABETES - The invention provides with means to predict, in subjects affected by type 2 diabetes (T2D), the probability of developing complications related to the disease. The invention involves 1) use of genetic features (SNPs, STRs, or other genomic markers) together with other chromosomal features and phenotypic information to establish a patient profile specifically developed for prediction of complications of T2D 2) use of a set of SNPs allowing to discriminate between individuals according to their descent. A preferred set of genomic markers selected for their association with complications of T2D is provided that can be used with a set of complementary phenotypic markers to evaluate the risk for an individual affected by T2D to develop complications related to the disease and to evaluate the likelihood that an individual affected by T2D type will benefit from treatments reducing the risk of developing such complications. | 2010-04-22 |
20100099092 | Methods for determination of haplotype dissection - A method for molecular haplotyping of a subject is disclosed. The method comprises: randomly selecting a set of chromosomes in each of a plurality of lyzed diploid cells of the subject, collecting the selected chromosomes from said plurality of cells into a plurality of sample tubes, wherein each sample tube contains chromosomes selected from one or more cells, genotyping genomic DNA in each sample tube, and determining haplotype of the alleles based on allele nucleotide sequence information and corresponding nucleotide signal intensities from genotyping data. Other methods for molecular haplotyping using single cell lysate or single cell microdissection are also disclosed. | 2010-04-22 |
20100099093 | Biomarkers for the Identification Monitoring and Treatment of Head and Neck Cancer - This present invention compositions and methods of treating cancer and methods of accessing/monitoring the responsiveness of a cancer cell to a therapeutic compound. | 2010-04-22 |
20100099094 | METHOD OF DETECTING NUCLEIC ACID AMPLIFICATION REACTION - The present invention provides a method of detecting a nucleic acid amplification reaction, including the steps of adding a sample nucleic acid to a nucleic acid amplification buffer containing a reducing agent molecule, a redox molecule and a magnesium ion, to conduct an amplification reaction, measuring a reduction current produced by a reduction reaction of the reducing agent molecule with the redox molecule, under the conditions that when the amplification reaction of the sample nucleic acid has proceeded in the buffer, pyrophosphoric acid formed with the progress of amplification of the sample nucleic acid forms magnesium pyrophosphate with the magnesium ion, thereby decreasing a magnesium ion concentration of the buffer, and determining, from the magnitude of the reduction current measured above, whether the sample nucleic acid has been amplified or not. | 2010-04-22 |
20100099095 | METHODS FOR DETERMINING PROGNOSES AND THERAPEUTIC INTERVENTIONS FOR OVARIAN CARCINOMAS - Methods for determining the prognosis and therapeutic interventions for cancer and for utilizing the expression of the homeoprotein Six1 to determine the prognosis and therapeutic interventions for cancer, in particular for ovarian carcinomas. | 2010-04-22 |
20100099096 | Compositions and Methods for Identifying Factors Affecting Protein Stability - The present invention is directed to retroviral vectors, and libraries generated from the vectors that can be used in assessing the stability of proteins and in correlating degradation with a specific E3 ubiquitin ligase. The libraries can also be used to identify factors that alter the degradation of proteins of therapeutic value and which have potential use clinically. | 2010-04-22 |
20100099097 | A Flow Through System, Flow Through Device And A Method Of Performing A Test - The invention relates to a flow through system for quantifying a target component in a liquid. The flow through system comprises a flow-through device comprising a flow path comprising a marker section, a capture section downstream to said marker section, and at least two quantification sections. The marker section comprises a non-immobilized marker. The capture section comprises a capture zone with an immobilized capture agent, and the at least two quantification sections comprise a pre-capture quantification section placed downstream to the marker section and up stream to the capture section, and a post-capture quantification section placed downstream to the capture section. The system further comprises a quantification unit for each of said quantification sections. The quantification unit(s) being arranged to quantify marker containing components and/or particles passing through said respective quantification sections. The invention also relates to a flow through device for such flow through system and a method of determining the amount of target component in a liquid using a flow through system. | 2010-04-22 |
20100099098 | METHODS AND COMPOSITIONS FOR DIAGNOSING AND MONITORING TRANSPLANT REJECTION - Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described. | 2010-04-22 |
20100099099 | METHOD AND TEST KIT FOR THE RAPID DETECTION OF SPECIFIC NUCLEIC ACID SEQUENCES, ESPECIALLY FOR DETECTING OF MUTATIONS OR SNPs - A method and a test kit for rapid detection of specific nucleic acid sequences, especially for detection of mutations or single nucleotide polymorphisms (SNPs), in which the detection reaction takes place in two steps. The first step involves the target-specific amplification reaction, coupled with the probe-hybridization reaction using fluorescence-labeled allele-specific amplification primers. In the second step, the fluorescence is detected by means of commercial fluorescence readers. Genotyping is carried out from the ratio of the end-point fluorescence of the samples and negative controls. | 2010-04-22 |
20100099100 | 'ULTRA-HIGH MULTIPLEX ANALYTICAL SYSTEMS AND METHODS" - Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination. | 2010-04-22 |
20100099101 | METHODS FOR TREATING, DIAGNOSING, AND MONITORING LUPUS - Methods of identifying, diagnosing, and prognosing lupus, including certain subphenotypes of lupus, are provided, as well as methods of treating lupus, including certain subpopulations of patients. Also provided are methods for identifying effective lupus therapeutic agents and predicting responsiveness to lupus therapeutic agents. | 2010-04-22 |
20100099102 | Development of Diagnostic Markers From the Saliva of Head and Neck Cancer Patients - The present invention relates to biomarkers that are useful for the detection of cancer. The invention further relates to biomarkers and methods of using biomarkers for the early detection of head and neck cancer. | 2010-04-22 |
20100099103 | Antibody Libraries - The present invention features improved in vitro RNA display libraries to allow reliable expression and selection of scFv antibody molecules from expression libraries. The scFv antibody libraries of the invention contain an optimized, shortened inter-domain linker that improves expression scFv antibody expression. The scFv antibody libraries also include short nucleic acid barcodes that allow for identification of individual library clones, libraries or subsets thereof. Primers for generating, amplifying and spectratyping the scFv antibody libraries of the invention are also provided. | 2010-04-22 |
20100099104 | GENETIC TEST FOR THE IDENTIFICATION OF CARRIERS OF COMPLEX VERTEBRAL MALFORMATIONS IN CATTLE - Genetic markets for identifying bovine carriers of complex vertebral malformation (CVM) disease gene are described. The genetic markers, including the microsatellite markers, BM4129, INRAA003, BMS2790, ILSTS029, INRA123, BM220, HUJ246, BMS862, BMS937, BL1048, BMS2095 and BMS1266 and the bovine SLC35A3 gene, are located on bovine chromosome BTA3. The G/T polymorphism at position 559 of the bovine SLC35A3 gene is identified as being causative and diagnostic for CVM in cattle. | 2010-04-22 |
20100099105 | ANTIBODIES HAVING BINDING SPECIFICITY FOR THE EXTRACELLULAR DOMAIN OF A BREAST CANCER RESISTANCE PROTEIN (BCRP) - The present invention includes methods of identifying and/or isolating stem cells based on expression of BCRP. The present invention also describes methods of obtaining and/or using cell populations enriched for stem cells. In addition, methods are provided for diagnosing and/or prognosing leukemia, particularly human acute myelogenous leukemia (AML), through assaying for BCRP expression in leukemic cells. | 2010-04-22 |
20100099106 | CELL DEATH INHIBITOR - The cell death inhibitor comprising a substance capable of binding to macrophage migration inhibitory factor is useful as a preventive/therapeutic agent for, e.g., heart diseases, neurodegenerative diseases, cerebrovascular diseases, central nervous infections, traumatic diseases, demyelinating diseases, bone/joint diseases, kidney diseases, liver diseases, myelodysplastic diseases, arteriosclerosis, diabetes, pulmonary hypertension, sepsis, inflammatory bowel diseases, autoimmune diseases, failure accompanying rejection in organ transplantation, AIDS, cancer, etc. | 2010-04-22 |
20100099107 | METHOD FOR IDENTIFYING AN INTESTINAL PHENOTYPE - The present invention relates to a method for identifying cells having a predisposition to develop an intestinal phenotype, wherein the cells are characterized by the loss of expression of the RUNX3 gene and the expression of one or more intestinal marker genes. In particular, the invention is directed to the identification of cells, which exhibit an intestinal phenotype representing a precursor of gastric cancer. Furthermore, the invention discloses a method for identifying a compound inhibiting the development of an intestinal phenotype in cells having a predisposition to develop an intestinal phenotype. Finally, the invention also relates to kits of parts for performing these methods. | 2010-04-22 |
20100099108 | Method for Detecting, Isolating, and Characterizing Cells from Body Samples by Transfection with Nucleic Acid Constructs - A method for detecting or isolating disease-associated cells or pluripotent stem cells from body samples is provided where cells of a body sample are transfected with nucleic acid constructs that include the following components: (a) a promoter element containing at least one DNA site for binding one or more transcription factors; and (b) a reporter gene that enables the diseased or stem cells to be detected. When the method is used for detecting disease-associated cells, the transcription factor initiates at least one signalling activity in the disease-associated cells that is not present in healthy cells. | 2010-04-22 |
20100099109 | Methods for Analyzing Drug Response - The present invention provides methods, instruments, reagents, kits and the biology involved in analyzing drug response. An embodiment of the present invention provides an approach for the characterization a plurality of pathways in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states of cellular molecules such as proteins, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Some of these categories include redox potential, ITIM phosphorylation, intracellular pH and other categories allows for characterization of such pathways and cell populations. Also, the present analysis is useful for the analysis of the effect of compounds on potential target cells. | 2010-04-22 |
20100099110 | Allele-Specific Amplification - The present invention includes a method of allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, but having a 3′-terminal nucleotide complementary to only one variant of the target sequence and having at least one nucleotide with a base covalently modified at the exocyclic amino group, wherein the allele-specific oligonucleotide is extended by a nucleotide-incorporating biocatalyst predominantly when hybridized to the variant of the target sequence for which it has said complementary 3′-terminal nucleotide. | 2010-04-22 |
20100099111 | ANTIBODIES AGAINST A PROTEIN ENTITLED 161P2F10B - Antibodies and methods of using same against products of the gene designated 161P2F10B and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit a humoral or cellular immune response. | 2010-04-22 |
20100099112 | QUANTITATIVE LATERAL FLOW SYSTEM AND ASSAY - The present invention relates to a lateral flow assay and system, including a test strip, for detection and quantification of analytes in samples, such as samples containing cells and fluid, where the assay is volume independent, and the sample size is less than about 100 μl, where the test strip includes a first membrane such as a sample filter, that is in capillary contact with an optional second membrane, such as a fluid collector, the second membrane, if present is in capillary contact with an optional third membrane, such as a conjugate pad containing a mobilizable detectable agent, or with a fourth membrane, which is a chromatographic strip, which optionally contains a mobilizable detectable agent, all such membranes being in fluid contact with a fifth membrane, such as a buffer pad, a sixth membrane, such as an absorbent pad, optionally a seventh membrane, which is also an absorbent pad, a capture band for capturing the analyte and at least one control band, or alternatively, the chromatographic strip contains the mobilizable detectable agent in place of a conjugate pad, where the test strip is configured to support removal of red blood cells from the sample and to allow uni-directional or bi-directional fluid flow of fluid from the sample filter to the capture band to be retained therein and detected thereon. | 2010-04-22 |
20100099113 | MINIMIZED SMALL PEPTIDES WITH HIGH AFFINITY FOR FACTOR VIII AND FACTOR VIII-LIKE PROTEINS - The present invention relates to the composition of small molecules and their use in the field of protein isolation, purification, stabilizing and/or enhancing its activity. In particular, the present invention relates to the synthesis and optimization of compounds comprising small peptides and peptide derivatives with affinity to coagulation Factor VIII and/or Factor VIII-like polypeptides and/or domains thereof. These compounds are useful for labeling, detecting, identifying, isolating and preferably for purifying, stabilizing and enhancing the activity of Factor VIII, Factor VIII-like polypeptides or domains thereof from physiological and non-physiological solutions comprising same. Further, these compounds may be used as ligands, which bind Factor VIII, Factor VIII-like polypeptides or domains thereof in methods of the present invention. | 2010-04-22 |
20100099114 | ANALYTICAL STRIP AND DETECTING METHOD USING THE SAME - An analytical strip and a detecting method using the analytical strip are provided. The analytical strip includes a substrate having a channel thereon. The channel has a first region, a second region and a third region, which are arranged successively. A first antibody is localized in the first region. A saccharide and a peroxidase are localized in the first or second region. A second antibody for recognizing a different epitope of an identical antigen with the first antibody is immobilized in the second region. A substrate reagent including a saccharide oxidase is localized in the third region. | 2010-04-22 |
20100099115 | SYSTEMS AND METHODS FOR PREPARING AND ANALYZING SAMPLES - The invention relates to systems and methods for preparing and analyzing samples (e.g., mucosal samples) for a microorganism of interest. In particular, the systems and methods are useful for detecting one or more analytes characteristic of a microorganism (i.e., microbe) of interest, such as components of cell walls that are characteristic of a microbe, particularly | 2010-04-22 |
20100099116 | Methods for Analysis of Hedgehog Pathway Inhibitors - One aspect of the present invention relates to a method of ascertaining the inhibitory activity in a mammal of a candidate inhibitor of the hedgehog pathway. In certain embodiments, the candidate inhibitor is administered systemically. In certain embodiments, the mammal is a rodent or primate. In certain embodiments, the mammal is a mouse. In certain embodiments, the candidate inhibitor is a small molecule or natural product. | 2010-04-22 |
20100099117 | DIAGNOSTIC METHOD FOR DETERMINING THE SUSCEPTIBILITY TO DELIVERY AND REAGENT KIT FOR USE THEREFOR - The invention relates to a diagnostic method for detecting susceptibility to delivery, and to a test kit for this purpose. A low, but higher than baseline level concentration of Insulin-like Growth Factor Binding Protein 1 (IGFBP-1), which is due to leakage from decidual cells, is detected by an immunological assay in a vaginal secretion sample. | 2010-04-22 |
20100099118 | METHODS OF DETERMINING TOTAL PON1 LEVEL - A method of determining an amount of total PON1 in a sample of a subject is disclosed. The method comprises:
| 2010-04-22 |
20100099119 | Detecting a Bacterial Process in Chronic Rhinosinusitis - The present invention provides a method for identifying bacterial induced rhinosinusitis. The method comprises obtaining a nasal or paranasal mucus sample and detecting the presence of neutrophil degranulation in the mucus sample. Degranulation of neutrophils can be determined by morphological analysis of the cells in the mucus or by detection of released (i.e., “free”) granule content markers such as neutrophil elastase or myeloperoxidase. Based on an accurate determination of the cause of sinusitis as described herein, an appropriate treatment can be instituted. | 2010-04-22 |
20100099120 | Method for staining substances having a phosphate group - It is intended to provide a method by which a substance having a phosphate group can be easily detected from a biological sample or the like, a method by which a phosphorylated amino acid residue is easily identified and a compound which can be used in the methods because of having a high coordinate bond forming capacity with a substance having a phosphate group. A metal complex compound represented by the general formula (I): {wherein M represents a metal atom which can be a divalent cation, Rs may be the same or different from one another and represent a hydrogen atom, an alkyl group having 1 to 16 carbon atoms, an acyl group, an alkoxycarbonyl group, an acylalkyl group, an alkoxycarbonylalkyl group, a carboxyalkyl group, a carbamoylalkyl group, a cyanoalkyl group, a hydroxyalkyl group, an aminoalkyl group or a haloalkyl group (here, the carbon number of alkyl moiety of these groups is 1 to 16), a carboxyl group, a carbamoyl group, a cyano group, a hydroxyl group, an amino group or a halogen group, X represents a ligand and Y represents a labeling group} can easily identify a substance having a phosphate group because of having a high coordinate bond forming capacity with a substance having a phosphate group and having the labeling group. | 2010-04-22 |
20100099121 | METHOD FOR THE DIAGNOSIS OF CANCERS BY MEASURING THE CHANGES OF GLYCOSYLATION OF PROTEINS RELATED TO TUMORIGENESIS AND METASTASIS AND KIT FOR DIAGNOSIS OF CANCERS USING THE SAME - The present invention relates to a method for diagnosing cancers by measuring proteins associated with tumorigenesis and metastasis, and a diagnostic kit using the same, particularly relates to the method for diagnosing cancers by measuring the changes of glycosylation of proteins and the kit for diagnosis of cancers using the said method. The method and kit of the present invention can effectively be used for the sensitive diagnosis of cancers comprising colon cancer, stomach cancer, lung cancer and liver cancer. | 2010-04-22 |
20100099122 | FERRIC REDUCTASE ACTIVITY OF HISTOPLASMA CAPSULATUM Y-GLUTAMYLTRANSFERASE - A novel gamma-glutamyltransferase gene and its encoded protein isolated from the fungus | 2010-04-22 |
20100099123 | Soluble Human M-CSF Receptor and Uses Thereof - Soluble human M-CSF receptor is provided, along with pharmaceutical compositions containing such receptor, kits containing a pharmaceutical composition, and methods of diagnosing and treating diseases and disorders associated with M-CSF such as bone loss in a subject afflicted with an osteolytic disease. | 2010-04-22 |
20100099124 | Method for Diagnosing Diseases Based on Levels of Anti-Glycan Antibodies - Disclosed are methods for diagnosing Crohn's disease (CD) or anti-phospholipid syndrome by measuring levels of antibodies to glycans in a biological sample. | 2010-04-22 |
20100099125 | METHOD FOR MEASURING LOW-DENSITY LIPOPROTEIN (LDL) CHOLESTEROL AND TEST PIECE FOR MEASURING LDL CHOLESTEROL - An LDL cholesterol measurement method that can be used with a test piece is provided. The LDL cholesterol measurement method for measuring LDL cholesterol in a sample has (A) a step of providing a total-cholesterol measurement portion and a non-LDL cholesterol measurement portion for measuring non-LDL cholesterol, which is cholesterol other than LDL cholesterol; (B) a step of measuring the total cholesterol in the sample in the total-cholesterol measurement portion; (C) a step of measuring the non-LDL cholesterol in the sample in the non-LDL cholesterol measurement portion; and (D) a step of obtaining the LDL cholesterol level in the sample by subtracting the non-LDL cholesterol value measured in the step (C) from the total-cholesterol value measured in the step (B). | 2010-04-22 |
20100099126 | METHOD OF CALCULATING ENZYMATIC REACTION RATE, COMPUTER PROGRAM PRODUCT AND METHOD OF DETERMINING AMOUNT OF ENZYME IN SAMPLE - A method of calculating an enzymatic reaction rate using the largest frequency value of a slope of a sub-group, a computer program product capable of performing the method of calculating an enzymatic reaction rate, and a method of determining the amount of an enzyme in a sample are provided. | 2010-04-22 |
20100099127 | SYSTEM AND METHOD FOR ACQUIRING AND STORING BIOLOGICAL SAMPLES - A system and method that may include grasping a sample collection medium with a holder; inserting the sample collection medium into a medium storage device within a first container such that at least a first portion of the sample collection medium is securely held within the first container; separating a second portion of the sample collection medium retained within the holder from the first portion of the sample collection medium held within the first container; and inserting the second portion of the sample collection medium into a second container. | 2010-04-22 |
20100099128 | NOVEL PEPTIDASE SUBSTRATES - The present invention relates to an enzyme substrate for detecting peptidase activity in microorganisms, of formula (I) below: | 2010-04-22 |
20100099129 | Transcobalamin II assay method - An assay method for determining transcobalamin saturation wherein a transcobalamin containing liquid sample is contacted with a porous substrate with immobilized thereon a transcobalamin immobilizing ligand and with a reporter-labelled transcobalamin binding partner and wherein signals from reporter labels which become immobilized on said substrate are detected, characterised in that one of said ligand or said binding partner comprises a first ligand or binding partner capable of specific binding to holo transcobalamin and a second ligand or binding partner capable of binding to apo transcobalamin or to holo and apo transcobalamin. | 2010-04-22 |
20100099130 | METHODS AND DEVICES FOR MONITORING PLATELET FUNCTION - A method of monitoring platelet function comprising: passing blood removed from a mammal through a passageway comprising (i) a shear generating restriction to generate a platelet mass in the passageway and (ii) a platelet aggregate trap; and monitoring the flow or composition of the blood in the passageway to detect formation of the platelet mass, wherein the blood passes through the passageway in one direction and only one time. A method of monitoring platelet function comprising: passing blood removed from a mammal through a passageway comprising (i) a shear generating restriction to generate a platelet mass in the passageway and (ii) a platelet aggregate trap; and monitoring the flow or composition of the blood in the passageway to detect formation of the platelet mass, wherein the blood is recirculated through the passageway and the blood flows only one direction through the passageway. | 2010-04-22 |
20100099131 | SOLUTION OF MATRIX - A solution of a matrix contains a liquid mixture consists of acetonitrile and water as main solvent component, wherein a volumetric ratio of acetonitrile and water is within a range of from acetonitrile 6.5: water 3.5 to acetonitrile 8: water 2, and wherein sinapinic acid is contained as the matrix. | 2010-04-22 |
20100099132 | BACTERIAL GROWTH INDUCER - The present invention relates to methods of preparing bacterial growth inducers, and in particular to novel bacterial growth inducers/resuscitators prepared by such methods. The invention extends to various applications of such growth inducers, for example in clinical and environmental diagnostics, in reviving not immediately culturable (NIC) bacteria, and in the analyses of microbial populations in blood, food and soil samples. | 2010-04-22 |
20100099133 | METHOD AND APPARATUS FOR THE TREATMENT OF SPECIMENS - A method and an apparatus for the treatment of cytological and histological specimens are described. A treatment program comprising multiple treatment parameters is predetermined. The specimens are introduced in accordance with the predetermined treatment program sequentially into a plurality of treatment stations by means of a transport device. At least one of the process data time and number of specimens subject to simultaneous treatment in one particular treatment station and number of the treatment stations during execution of the treatment program are determined. These process data are evaluated for optimizing the treatment program as to at least one of processing time, number of treatment stations and sequence of treatment stations. | 2010-04-22 |
20100099134 | METHODS FOR DETECTING SULFHYDRYL-CONTAINING COMPOUNDS IN A BIOLOGICAL TEST SAMPLE - The invention relates to methods for detecting the presence of a compound of formula I in a biological test sample: | 2010-04-22 |
20100099135 | METHODS AND ASSAYS FOR ASSESSING THE QUALITY OF EMBRYOS IN ASSISTED REPRODUCTION TECHNOLOGY PROTOCOLS - The present invention provides methods and assays for assessing the presence, viability and/or developmental stage of an embryo. The present invention also provides method and assays for assessing the quality of an Assisted Reproduction Technology protocol. | 2010-04-22 |
20100099136 | Microfluidic Assay for Selection and Optimization of Drug Delivery Vehicles to Tumors - An apparatus and method for assaying a tumor drug delivery vehicle comprises a synthetic microvascular network of interconnected flow channels in fluid communication through a porous wall with a tissue space containing animal cells and means for quantifying drug delivery from the microvascular network to the animal cells. | 2010-04-22 |
20100099137 | Direct Antimicrobial Susceptibility Assay - An antimicrobial susceptibility assay, including an assay dish including at least one chamber, at least one growth medium carried by the assay dish, at least one antimicrobial agent sample positionable at a sample location adjacent a growth medium in the assay dish, at least one interpretive indication positionable at a predetermined distance from the sample location adjacent a growth medium in the assay dish, and at least one interfitting element, said at least one interfitting element configured cooperate with the assay dish to enable at least one of: a) more accurately positioning said at least one antimicrobial sample at the sample position in contact with the growth medium; b) carrying said at least one interpretive indication positionable at a predetermined distance from said sample position; said assay enabling the interpretative indication to be compared with a margin of a zone of inhibition of microbial organism growth on said growth medium to determine an assay result, wherein said result enables determination of at least one of: a) “susceptible;” “intermediate;” and, “resistant.” | 2010-04-22 |
20100099138 | MULTIPLE-VALENT OPSONOPHAGOCYTIC ASSAY SELECTION PANEL ARRAYS AND USES THEREFOR - This application discloses a multivalent opsonophagocytosis assay that does not rely on counting of bacterial colonies to determine bacteria viability following opsonophagocytosis. Instead, the method uses a metabolic colorimetric indicator to determine if viable bacteria are present. Also disclosed are arrays that can be used to determine the viability of bacteria following opsonophagocytosis. | 2010-04-22 |
20100099139 | MEANS AND METHODS FOR DETECTING BACTERIA IN A SAMPLE - The present invention provides a method for detecting and/or identifying specific bacteria within an uncultured sample. The method comprises steps selected inter alia from (a) obtaining an absorption spectrum (AS) of said uncultured sample; (b) acquiring the n dimensional volume boundaries for said specific bacteria; (c) data processing said AS; and, (d) detecting and/or identifying said specific bacteria if said m1 statistical correlation and/or said m features are within said n dimensional volume. | 2010-04-22 |
20100099140 | METHODS AND COMPOSITIONS FOR PREVENTING ARTIFACTS IN TISSUE SAMPLES - Methods and compositions for preventing artifacts in tissue samples fixed with an aldehyde-based fixative are described. The methods include fixing a tissue sample with an aldehyde-based fixative, such as a formalin fixative agent. After fixation, the tissue sample can be contacted with separate solutions that each contain an artifact preventing composition or a tissue stain. However, because the artifact preventing composition may increase the stain's shelf-life, the stain and the composition are preferably mixed before being added to the sample. The artifact preventing composition can include one or more amino acids, polyamines, and/or Schiff-base-forming compounds. The components of the composition can bind to or react with free fixative to prevent fixative artifacts. Additionally, reactions between the artifact preventing composition and free aldehyde-based fixative may be favorable due to the thermodynamics, small size, high ability to diffuse, and/or high concentration of the components of the artifact preventing composition. | 2010-04-22 |
20100099141 | Method and intermediates for preparing 2-alkoxy and 2-aryloxy estrogen compounds - The present invention relates to a method for preparing 2-alkoxy and 2-aryloxyestrogen compounds, and the intermediate compounds prepared during the use of this method, which intermediate compounds are useful intermediates in the preparation of certain physiologically active compounds. | 2010-04-22 |
20100099142 | Processing of Peptides and Proteins - The invention provides novel methionine aminopeptidase enzymes and their use. | 2010-04-22 |
20100099143 | Alanine 2,3-aminomutases and related polynucleotides - The present invention is directed to polypeptides that have enhanced alanine 2,3-aminomutase (AAM) activity and/or thermostability relative to the wild-type enzymes that have incidental AAM activity as a result of cross reactivity with alanine. In addition, the present invention is directed to a polynucleotides that encodes for the AAM polypeptides of the present invention, to nucleic acid sequences comprising the polynucleotides, to expression vectors comprising the polynucleotides operatively linked to a promoter, to host cells transformed to express the AAM polypeptides, and to a method for producing the AAM polypeptides of the present invention. | 2010-04-22 |
20100099144 | COMBINED USE OF CELL PERMEABLE NANOG AND OCT4 FOR INCREASING SELF-RENEWAL AND SUPPRESSING DIFFERENTIATION OF STEM CELLS - The present invention discloses cell permeable Nanog and Oct4 recombinant proteins that comprise a kaposi fibroblast growth factor 4 (kFGF4)-derived macromolecule transduction domain (MTD). Also disclosed are polynucleotides encoding the cell permeable Nanog and Oct4 recombinant proteins, a method of increasing self-renewal and suppressing differentiation of stem cells by treating the cells in combination with the cell permeable Nanog and Oct4 recombinant proteins, and the combined use of the cell permeable Nanog and Oct4 recombinant proteins for increasing self-renewal and suppressing differentiation of stem cells. | 2010-04-22 |
20100099145 | RECOMBINANT HUMAN EPO-FC FUSION PROTEINS WITH PROLONGED HALF-LIFE AND ENHANCED ERYTHROPOIETIC ACTIVITY IN VIVO - A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy. | 2010-04-22 |
20100099146 | Variants of Beta-Glucosidases - The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences. | 2010-04-22 |
20100099147 | Anti-IGF-1R Antibodies and Uses Thereof - The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-1) and insulin like growth factor 2 (IGF-2) to bind to IGF-1R, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention. | 2010-04-22 |
20100099148 | Novel Vectors for Production of Antibodies - Novel compositions for the production of the light and heavy chains of an antibody are provided. These novel compositions are also used to produce germline transgenic birds that can successfully pass the transgene encoding the antibody to their offspring. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes the light or heavy chain of an antibody, and the vectors comprising these components. In certain embodiments, these vectors are transposon-based vectors. Also provided are methods of making these compositions and methods of using these compositions for the production of the light and heavy chains of an antibody. In one embodiment, the antibody is a human monoclonal antibody. | 2010-04-22 |
20100099149 | STABILIZING COMPOSITIONS AND METHODS FOR EXTRACTION OF RIBONUCLEIC ACID - The present invention provides a composition and method for stabilizing ribonucleic acid (RNA) from biological samples such that the ribonucleic acid within the sample remains stable at room temperature. The composition comprises an anionic detergent and a buffering agent at a pH of about 5 to about 8.2 and is used in methods for extracting and storing ribonucleic acid from the biological sample. | 2010-04-22 |
20100099150 | POLYMERASE STABILIZATION BY IONIC DETERGENTS - The invention relates to a composition comprising (i) an enzyme with nucleic acid polymerase activity, (ii) an inert protein and, (ii) a zwitterionic detergent. The invention also relates to a composition comprising (i) an enzyme with nucleic acid polymerase activity, (ii) an inert protein and, (ii) a zwitterionic detergent. The invention further relates to a method for enzymatic nucleic acid synthesis comprising the steps of, (a) providing in a reaction mixture, a polymerase activity, a nucleic acid template, a zwitterionic detergent, a buffer, a salt, nucleotides and an inert protein and, (b) incubating the reaction mixture at a temperature which enables nucleic acid synthesis. | 2010-04-22 |
20100099151 | VERTICAL SUBMERSIBLE PHOTOBIOREACTOR FOR OBTAINING BIOFUELS - The invention relates to a vertical submersible photobioreactor for obtaining biofuels, consisting of: vertical towers ( | 2010-04-22 |
20100099152 | METHOD FOR PRODUCING L-AMINO ACID - L-amino acids such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, and L-cysteine are produced by culturing in a medium a bacterium having an L-amino acid-producing ability and wherein the bacterium has been modified so that the phosphotransacetylase activity is enhanced. | 2010-04-22 |
20100099153 | Method for producing L-amino acids using bacteria belonging to the genus escherichia - A method for producing lower alkyl ester of α-L-aspartyl-L-phenylalanine by cultivating a recombinant | 2010-04-22 |
20100099154 | PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF - The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system. | 2010-04-22 |
20100099155 | RECOVERY OF VOLATILE PRODUCTS FROM FERMENTATION BROTH - Provided are apparatuses and processes for the removal and purification of fermentation prepared one or more volatile organic compounds. The apparatuses comprise a fermentor unit, a vacuum side stripper unit ( | 2010-04-22 |
20100099156 | PROCESS FOR THE PREPARATION OF ETHANOL FROM STARCH - The present invention provides a process for the preparation of ethanol from starch. Specifically, the present invention provides a process for the preparation of ethanol from starch such as tapioca, potato, sweet sorghum, rice by liquification and saacharification of starch and subsequent fermentation of mono saccherides to ethanol in presence of thermophilic micro-organisms. | 2010-04-22 |