14th week of 2010 patent applcation highlights part 36 |
Patent application number | Title | Published |
20100086918 | Methods for High Sensitivity Detection of Genetic Polymorphisms - Multiplex PCR-based methods for detecting a variant polynucleotide having a nucleotide sequence differing from the wild-type nucleotide sequence of a nucleic acid molecule, wherein the variant polynucleotide is in a sample containing an excess of the wild-type nucleic acid molecule. The methods are particularly useful for detection of deletions from, or translocations and inversions in, genomic DNA. The susceptibility to, diagnosis of, and progression of a disease clinically related to the occurrence of such polymorphisms in an individual may also be confirmed and monitored using the multiplex PCR-based methods or by detecting RNA fusion transcripts in a sample that correspond to previously identified deletions, translocations or inversions in genomic DNA. | 2010-04-08 |
20100086919 | Devices and methods for immunoglobulin production - The present invention relates to devices and methods that are useful for screening and isolating cells that express a desired immunoglobulin. The present invention further relates to devices and methods that are useful in producing monoclonal antibodies from non-immortal cells (such as B cells) or immortalized cells (such as hybridoma cells). The devices and methods disclosed herein significantly improve the efficiency for monoclonal antibody production. | 2010-04-08 |
20100086920 | METHOD TO ASSESS CANCER SUSCEPTIBILITY AND DIFFERENTIAL DIAGNOSIS OF METASTASES OF UNKNOWN PRIMARY TUMORS - This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different tumor markers in a serum sample, which can be used to screen for and determine susceptibility to cancer as well as for the differential diagnosis of metastases from an unknown primary tumor. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of monoclonal antibodies used for cancer susceptibility assessment and for differential diagnosis of metastases from an unknown primary tumor. | 2010-04-08 |
20100086921 | GENETIC SUSCEPTIBILITY VARIANTS OF TYPE 2 DIABETES MELLITUS - Association analysis has shown that certain genetic variants are susceptibility variants for Type 2 diabetes. The invention relates to diagnostic applications of such susceptibility variants, including methods of determining increased susceptibility to Type 2 diabetes, as well as methods of determining decreased susceptibility to Type 2 diabetes in an individual. The invention further relates to kits for determining a susceptibility to Type 2 diabetes based on the variants described herein. | 2010-04-08 |
20100086922 | Assessment of chromosomal alterations to predict clinical outcome of bortezomib treatment - Disclosed herein are chromosomal loci associated with clinical outcome to treatment for multiple myeloma. Genome-wide changes observed in myeloma relate to prognosis and treatment response to a proteasome inhibitor. Compositions and methods are provided to assess DNA copy number at corresponding to markers of loci and genes found thereon which are amplified or deleted, overexpressed or underexpressed in myeloma tumors to predict response to treatment, time-to-progression and survival upon treatment. | 2010-04-08 |
20100086923 | USE OF ACETALS FOR ISOLATION OF NUCLEIC ACIDS - The invention provides the use of water-miscible liquid cyclic acetals for adsorbing a nucleic acid to a solid phase such as a substrate with a silica surface. To this end, the invention also provides compositions comprising said acetals. Methods are disclosed and claimed to purify nucleic acids from samples, as well as kits useful for performing these methods. The nucleic acids purified by a method of the invention are suited for assays aiming at the detection of a target nucleic acid. | 2010-04-08 |
20100086924 | USE OF TDE FOR ISOLATION OF NUCLEIC ACIDS - The invention provides the use of tetraethylene glycol dimethyl ether for adsorbing nucleic acids to solid phases such as those with silica surfaces. To this end, the invention also provides compositions comprising TDE. Methods are disclosed and claimed to purify nucleic acids from samples, as well as kits useful for performing these methods. Particularly, the invention encompasses methods for the purification of nucleic acids with low molecular weight. The nucleic acids purified by a method of the invention are suited for assays aiming at the detection of a target nucleic acid. | 2010-04-08 |
20100086925 | MICROFLUIDIC STRUCTURE FOR MULTI-ASSAY AND MICROFLUIDIC DEVICE COMPRISING THE SAME - Exemplary embodiments relate to a microfluidic structure including: a plurality of sample chambers; a reaction chamber in which at least two types of materials, which respectively specifically react with at least two types of target materials, are immobilized; a detection chamber connected to the reaction chamber; a path connecting the chambers; and a valve for opening and closing the path, and a microfluidic device including the microfluidic structure. Since at least two types of materials specifically binding to target materials are immobilized in a reaction chamber of the microfluidic structure, space may be efficiently used and the target materials may be assayed in a one-step test. An internal space of the microfluidic device using the microfluidic structure, the amount of samples, and costs for manufacturing the microfluidic device may be reduced, and internal quality control may be efficiently performed using the microfluidic structure as a control for the operations. | 2010-04-08 |
20100086926 | METHOD OF CHARACTERIZING SEQUENCES FROM GENETIC MATERIAL SAMPLES - Among other aspects provided herein is a method describing the use of Single Nucleotide Polymorphism (SNP) genotyping microarrays to resolve whether genetic material (such as genomic DNA) derived from a particular individual is present in a genetic material mixture (such as a complex genomic DNA mixture) is disclosed. Furthermore, it is demonstrated that the identification of the presence of genetic material (such as genomic DNA) of specific individuals within a series of complex genomic mixtures is possible. | 2010-04-08 |
20100086927 | DEPOSITION OF METAL OXIDES ONTO SURFACES AS AN IMMOBILIZATION VEHICLE FOR CARBOXYLATED OR PHOPHATED PARTICLES OR POLYMERS - Intermediates and methods for forming activated metal complexes bound to surfaces on oxide layers, immobilizing beads to the modified surface and articles produced thereby are described. Hydroxyl groups on the oxide surfaces are reacted with a metal reagent complex of the formula Y(L-Pol) | 2010-04-08 |
20100086928 | DETECTION OF ORGAN REJECTION - The present invention features methods and compositions for the non-invasive detection of organ rejection using a microRNA score. | 2010-04-08 |
20100086929 | DETECTION OF ANALYTES - A kit and article of manufacture for detecting an analyte is disclosed. The kit comprises:
| 2010-04-08 |
20100086930 | IMPROVED HOMOGENEOUS LUMINESCENCE BIOASSAY - A homogenous bioassay including i) a first group containing a short lifetime fluorescent acceptor capable of energy transfer, and ii) a second group containing a quencher capable of energy transfer from an acceptor, with the first and second groups linked by at least a first linkage. The bioassay measures the acceptor's fluorescence increase resulting from cleavage of the first linkage. The bioassay also includes iii) a third group containing a donor for energy transfer to the acceptor, where the donor is an up-conversion fluorescent compound, a long-lifetime fluorescent compound or an electrogenerated luminescent compound. A conformational or terminal epitope is created on the first group through cleavage of the linkage, and the third group includes a binder with affinity for this conformational or terminal epitope. The acceptor's fluorescence is brought about by exciting the donor. Also disclosed are kits for homogenous bioassays according to the method of the invention. | 2010-04-08 |
20100086931 | METHOD FOR ASSAYING ACTION OF ANTITUMOR AGENT USING DECREASE IN GENE EXPRESSION LEVEL AS INDEX - An object of the present invention is to provide a method, a probe, a primer, an antibody, a reagent, and a kit for assaying an action of a pladienolide derivative to a living subject. According to the present invention, there is provided a method for assaying an action of the pladienolide derivative using a decrease in gene expression level as an index. | 2010-04-08 |
20100086932 | BLADDER CANCER DIAGNOSIS AND/OR PROGNOSIS METHOD - The present invention relates to an in vitro non-invasive bladder cancer diagnosis and/or prognosis method based on the detection and quantification in bladder fluids of the gene expression of certain genes and/or combinations thereof acting as genetic markers of said disease. A bladder cancer diagnosis and/or prognosis kit based on the use of a set of probes suitable for the detection and quantification of the expression pattern of said genes is also contemplated. | 2010-04-08 |
20100086933 | SENSOR FOR DETECTING AN ANALYTE - The present invention relates to a sensor for detecting an analyte, to a sensor array, and to a method of detecting an analyte using the sensor of the invention. | 2010-04-08 |
20100086934 | Use of non-clonal chromosomal aberrations for cancer research and clinical diagnosis - A diagnostic method of determining tumorigenicity of a tissue specimen includes the steps of determining a magnitude of genome diversity in the tissue specimen, and diagnosing a likelihood of cancer in response to said step of determining the magnitude of genome diversity. The magnitude of genome diversity includes the determination of karyotypic heterogeneity in the tissue specimen, illustratively by detecting non-clonal chromosome aberrations (NCCAs). The detection of NCCAs includes the detection the frequency of NCCAs, and the diagnosis is responsive to the step of detecting the frequency of NCCAs. Detection of NCCAs advantageously includes the further step of screening lymphocytes. Also, the step of determining the presence of elevated genome diversity includes the step of applying Spectral Karyotyping to detect translocations throughout the genome. The diagnostic method is useful to determine drug resistance of a patient. | 2010-04-08 |
20100086935 | Identification, Monitoring and Treatment of Disease and Characterization of Biological Condition Using Gene Expression Profiles - A method provides an index that is indicative of the state of a subject, as to a biological condition, based on a sample from the subject. An embodiment of this method includes: deriving from the sample a profile data set, the profile data set including a plurality of members, each member being a quantitative measure of the amount of a distinct RNA or protein constituent in a panel of constituents selected so that measurement of the constituents enables evaluation of the biological condition; and in deriving the profile data set, achieving such measure for each constituent under measurement conditions that are substantially repeatable; and applying values from the profile data set to an index function that provides a mapping from an instance of a profile data set into a single-valued measure of biological condition, so as to produce an index pertinent to the biological condition of the subject | 2010-04-08 |
20100086936 | HEPATOCYTE PRECURSOR CELL LINES - The present invention is directed to methods for readily generating hepatocyte precursor cell lines that retain hepatocyte-specific functions after extensive in vitro culturing. The methods comprise isolating and culturing hepatocyte precursor cell lines under permissive culture conditions that suppress asymmetric cell kinetics and allow exponential growth of the precursor cells, followed by transferring the hepatocyte precursor cell lines to non-permissive culture conditions that allow expression of asymmetric cell kinetics and induce expression of hepatocyte-specific characteristics. | 2010-04-08 |
20100086937 | METHOD TO DETECT TREPONEMA PALLIDUM IMMUNOLOGICAL MARKERS FOR THE DIAGNOSIS OF SYPHILIS - This invention discloses using SPR technology to qualitatively detect the presence of | 2010-04-08 |
20100086938 | MASS SPECTROMETRY OF BIOLOGICAL SAMPLE USING IMMUNOPRECIPITATION - It is intended to provide an analysis method for a biological sample with clinical significance, which is a system being simple to such an extent that it can be applied to a clinical field, and capable of capping a molecule ionization suppression in mass spectrometry. Mass spectrometry of a biological sample using immunoprecipitation, comprising the steps of: preparing a sample containing an objective biological molecule; concentrating the biological molecule in the sample by immunoprecipitation using an antibody-bound carrier or a carrier to which a molecule capable of specifically binding to an antibody is bound; washing an immunoprecipitate of the biological molecule by using an aqueous solution containing a charge neutralizing agent as a washing liquid; and detecting the biological molecule by subjecting the washed immunoprecipitate to mass spectrometry. | 2010-04-08 |
20100086939 | DETERMINATION METHOD FOR ALLERGIC DISEASE - It is to provide a method for determining allergic diseases with a high sensitivity and accuracy which enables multilateral and global analysis with a minute amount of sample, even using body fluid other than blood such as saliva, nasal discharge and tears as a sample, particularly by suppressing nonspecific reaction as much as possible. A chemically modified diamond/DLC (Diamond-like Carbon) chip is activated with a reacting reagent, a coupling reaction with a peptide comprising allergen or allergen epitope is conducted, and a sample such as saliva, tears, and nasal discharge which has undergone pressure filtration with a low protein-adsorbing filter, is contacted with an allergen determination chip to which washing and blocking operations have been performed on unreacted active groups, and an allergen recognizing antibody in the sample captured by the allergen determination chip is detected by immunoassay using a labeled secondary antibody, wherein a glycine-containing solution is used for a washing solution and/or blocking solution used in the washing and blocking operations, is used. | 2010-04-08 |
20100086940 | Polynucleotide encoding an autoantigen associated with endometriosis - This invention provides a polynucleotide encoding Repro-EN-1.0 and IB1, polypeptides associated with endometriosis. Auto-antibodies against Repro-EN-1.0 and IB1 have been found in subjects diagnosed with endometriosis. This invention also provides methods of using this polynucleotide and polypeptide. | 2010-04-08 |
20100086941 | Methods for determining aged based accumulation of senescent cells using senescence specific DNA damage markers - One disclosure provides a method for determining a senescence based disorder by detection of cells with senescence specific DNA damage markers which includes the step of providing a sample with one or more cells. It also includes the steps of identifying with immunodetection the presence of activated DNA damage response proteins that are shown to be activated with senescence and identifying with immunodetection the inactivation of DNA damage response proteins that are shown to be inactive in senescence. | 2010-04-08 |
20100086942 | COMPOUNDS - The present invention relates to binding members, especially antibody molecules, for CXCL13. The binding members are useful for the treatment of disorders associated with CXCL13, including arthritic disorders such as rheumatoid arthritis. | 2010-04-08 |
20100086943 | METHOD FOR THE DETECTION OF POST-TRANSLATIONAL MODIFICATIONS - Method for the detection in homogeneous medium of a post-translational modification of a protein substrate catalyzed by a cell enzyme, characterized in that the post-translational modification reaction takes place in intact living cells, in that these cells comprise a heterologous expression vector coding for a fusion protein comprising the protein substrate and a first coupling domain and in that it comprises the following stages: (v) Incubation of the cells in the presence or in the absence of a compound to be tested capable of modulating the activity of said enzyme, (vi) Addition to the reaction medium of a first fluorescent compound member of a first pair of FRET partners covalently bonded to a coupling agent capable of binding specifically to the first coupling domain present on the protein substrate, (vii) Addition to the reaction medium of a second fluorescent compound member of this first pair of FRET partners, and covalently bonded to a binding domain specific to the site of the protein substrate having undergone the post-translational modification and not binding to the non-modified protein substrate, (i) Measurement of the FRET signal emitted by the sample, this signal being representative of the quantity of protein substrate having undergone said post-translational modification; and cells for the implementation of said method. | 2010-04-08 |
20100086944 | Methods and Compositions for Diagnosis and Prognosis of Renal Artery Stenosis - The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects in the context of renal artery stenosis (RAS). In particular, the invention relates to using assays that detect NGAL, their use to diagnose RAS in subjects suffering from hypertension, and their use in prognosis, particularly of mortality and worsening renal function. | 2010-04-08 |
20100086945 | DIAGNOSTIC METHOD FOR DISEASES BY SCREENING FOR HEPCIDIN IN HUMAN OR ANIMAL TISSUES, BLOOD OR BODY FLUIDS AND THERAPEUTIC USES THEREFOR - The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding to the amino acid sequence between and including amino acids 25 and 49 of a hepcidin precursor protein, and quantifying the hepcidin precursor level using an assay based on binding of the antibody and the polypeptide; wherein the non-physiological level of prohepcidin is indicative of the disease condition. The present invention also concerns diagnostic methods and kits for applications in genetic technological approaches, such as for overexpressing or downregulating hepcidin. | 2010-04-08 |
20100086946 | PLGF, FLT1 AND ENDOGLIN FOR DIAGNOSING ANGIOGENIC STATUS IN CORONARY ARTERY DISEASE - Described are methods for diagnosing the angiogenic status of a subject suffering from coronary heart disease comprising determining the amounts of placental growth factor or a variant thereof, endoglin or a variant thereof and soluble FLT1 or a variant thereof in a sample of a subject suffering from coronary heart disease and comparing the amounts determined with reference amounts, whereby the angiogenic status is diagnosed. Also disclosed are diagnostic devices and kits for carrying out the aforementioned methods | 2010-04-08 |
20100086947 | USE OF FLOW-CYTROMETRIC ANALYSIS TO OPTIMIZE CELL BANKING STRATEGIES FOR CHO CELLS - Production of biopharmaceuticals from CHO cells requires generation of master-, working- and post-production cell banks of high quality, partly under GMP conditions. An optimal cryopreservation strategy is needed for each new production cell line, particularly with regard to the desire to establish production processes that are completely devoid of serum or even any animal components and to ensure robust thaw performance for reliable production. Here we describe a novel strategy employing flow cytometric (FC) analysis of Annexin V-stained cells for high-throughput characterization of CHO cell banks. Our data show that this method enables evaluation of a cryopreservation procedure just 6 h after thaw. | 2010-04-08 |
20100086948 | Ovarian Cancer Biomarkers and Uses Thereof - The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of ovarian cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose ovarian cancer or permit the differential diagnosis of a pelvic mass as benign or malignant. In another aspect, methods are provided for diagnosing ovarian cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having ovarian cancer, or the likelihood of the individual having ovarian cancer is determined, based on the at least one biomarker value. | 2010-04-08 |
20100086949 | RETENTATE CHROMATOGRAPHY AND PROTEIN CHIP ARRAYS WITH APPLICATIONS IN BIOLOGY AND MEDICINE - This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery. | 2010-04-08 |
20100086950 | IP-10 BASED IMMUNOLOGICAL MONITORING - The present invention relates to an immunological method and, more particularly, a method for measuring cell-mediated immune reactivity (CMI) in mammals based on the production of IP-10. The invention further discloses an assay and a kit for measuring CMI to an antigen using whole blood or other suitable biological samples. The methods of the present invention are useful in therapeutic and diagnostic protocols for human, livestock and veterinary and wild life applications, thus the invention further relates to a method for diagnosing an infection in a mammal. | 2010-04-08 |
20100086951 | Pan-Kinase Activation and Evaluation of Signaling Pathways - Methods and reagents are provided for determining the activation state of a signal transduction pathway signaling protein. There exists a need in the art for methods that can monitor the efficacy of a signal transduction inhibitor in a patient. Other needs exist for detecting and monitoring certain disease or disorders that are associated with aberrant activation of a signal transduction pathway signaling protein. The present assay provides a highly sensitive assay that is also useful in patient populations in which obtaining a large cellular sample is difficult, for example, neonates. | 2010-04-08 |
20100086952 | ASSAYS FOR MEASURING PHOSPHATE MODIFICATION ENZYME ACTIVITY - The present invention relates to assays that can measure the activity of enzymes that catalyze phosphate modifications, such as kinases, phosphatases, cyclases and phosphodiesterases. The assays can also be used to identify and screen for substances that modulate the activity of kinases, phosphatases, cyclases and phosphodiesterases. | 2010-04-08 |
20100086953 | Blood Coagulation Assays - The invention relates to methods for determining the activity of a proteolytic coagulation factor of the blood coagulation cascade in a body fluid such as whole blood or plasma. A combination is provided in a reaction mixture. The combination comprises the sample and an activation agent for activating a proteolytic coagulation factor of the blood coagulation cascade or for activating the blood coagulation cascade. The effect of the activating on a reagent system comprising a cleavable moiety is evaluated. The cleavable moiety is or becomes bound to a chemiluminescent agent or a sensitizer agent or both. The chemiluminescent agent and the sensitizer agent are related in that, when in close proximity, energization of the sensitizer agent results in energization of the chemiluminescent agent. The effect of the activating is related to the activity of a proteolytic coagulation factor of the blood coagulation cascade wherein the effect is the extent of cleavage of the cleavable moiety. | 2010-04-08 |
20100086954 | Small Volume In Vitro Analyte Sensor and Methods of Making - A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent. | 2010-04-08 |
20100086955 | Small Molecule Inhibitors of Ghrelin O-Acyltransferase - Ghrelin O-acyltransferase (GOAT) is inhibited with designed small molecules. Methods comprise contacting the GOAT with an inhibitor and detecting a resultant inhibition. | 2010-04-08 |
20100086956 | DETECTION OF HIV-RELATED PROTEINS IN URINE - A method for detecting HIV infection in a mammal is disclosed. The method contains the steps of isolating exosomes from a urine sample of a mammal and detecting the presence of HIV-specific biomarker in said isolated exosomes. A method for diagnosing a mammal with an HIV-associated disease, in particular, HIV-associated nephropathy is also disclosed. | 2010-04-08 |
20100086957 | METHOD FOR MONITORING INTRACELLULAR TYROSINE PHOSPHATASE ACTIVITY - The invention relates in general to tyrosine dephosphorylation. More specifically, the invention relates to methods and compositions for monitoring intracellular tyrosine dephosphorylation at the single cell level. The invention further relates to techniques that can be used as aid in the development of novel therapeutics, and monitor regulation of intracellular tyrosine phosphatase activity at the single cell level. | 2010-04-08 |
20100086958 | NOVEL ENZYME - Novel FDH enzymes are provided herein, including novel NADPH-specific and NADH-specific FDH enzymes. Additionally, methods are provided utilizing these novel enzymes in catalytic systems for in situ regeneration of NADPH or NADH. Further aspects of the invention relate to the definition and use of crystal structures of these novel enzymes. | 2010-04-08 |
20100086959 | FILTRATION UNIT AND METHOD FOR THE MICROBIOLOGICAL ANALYSIS OF LIQUID SAMPLES - The invention relates to a filtration unit, comprising a membrane filter that can be disposed on a filter support of a bottom part and an attachment that can be placed on the bottom part, wherein the membrane filter has a reinforcing edge, and wherein the membrane filter can be clamped to a clamping part of a cover of a culture medium unit for removal purposes and introduced into the culture media unit. The invention further relates to a method for the microbiological analysis of liquid samples following a filtration process, wherein after removing an attachment a membrane filter is lifted off a filter support for pouring in the liquid sample and set down on a surface of a culture medium disposed in the bottom part of a culture medium unit, and the bottom part is covered by a cover. The cover is placed on the membrane resting on the filter support such that a clamping part present on the filter support clamps to a reinforcing edge of the membrane. The cover is lifted off the filter support together with the membrane and placed on the bowl-shaped bottom part such that the bottom of the membrane facing away from the cover rests on the top of the nutrient medium facing the cover. | 2010-04-08 |
20100086960 | METHODS FOR THE DIAGNOSIS OF OVARIAN CANCER HEALTH STATES AND RISK OF OVARIAN CANCER HEALTH STATES - The present invention describes a method for predicting a health-state indicative of the presence of ovarian cancer (OC). The method measures the intensities of specific small organic molecules, called metabolites, in a blood sample from a patient with an undetermined health-state, and compares these intensities to those observed in a population of healthy individuals and/or to the intensities previously observed in a population of confirmed ovarian cancer-positive individuals. Specifically, the present invention relates to the diagnosis of OC through the measurement of vitamin E isoforms and related metabolites. The method enables a practitioner to determine the probability that a screened patient is positive or at risk for ovarian cancer. | 2010-04-08 |
20100086961 | Small Volume In Vitro Analyte Sensor and Methods of Making - A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent. | 2010-04-08 |
20100086962 | HEMATOLOGY CONTROLS AND METHODS - An integrated hematology control and methods for making the same, including a first cellular component derived from a plurality of processed animal red blood cells other than human blood cells and a second cellular component derived from a plurality of processed animal red blood cells other than human blood cells and a plurality of human blood cells, wherein the control simulates erythroblasts and white blood cells of a human blood sample on an automated blood analyzer. | 2010-04-08 |
20100086963 | AUTOMATED SEED SAMPLER AND METHODS OF SAMPLING, TESTING AND BULKING SEEDS - An automated system for sampling seeds generally includes an automated sampler operable to remove a tissue sample from a seed, a seed tray configured to receive from the automated sampler the seed from which the tissue sample is removed, and a sample tray configured to receive the tissue sample removed from the seed. A table supports the seed tray and the sample tray, and an index mechanism is operable to move the table to bring the seed tray into position for receiving from the automated sampler the seed from which the tissue sample is removed, and to bring the sample tray into position for receiving the tissue sample removed from the seed. | 2010-04-08 |
20100086964 | APPARATUS AND METHOD FOR IDENTIFYING AT LEAST ONE SPECIMEN SLIDE - An apparatus and method for tagging a specimen slide are described. The apparatus comprises a receiving region for receiving at least one cassette magazine, a reading unit for reading the machine-readable coded information of a cassette identifier of a cassette, and a tagging unit for generating a machine-readable coded information for tagging the specimen slide with a specimen slide identifier that depends on the cassette identifier. Data are transferred from the microtome to the apparatus via the data transfer path as soon as the cassette is inserted into the microtome, and only then can the machine-readable coded information for tagging the specimen slide be applied onto the specimen slide by the tagging unit. | 2010-04-08 |
20100086965 | METABOLIC ENGINEERING OF ARABINOSE-FERMENTING YEAST CELLS - The invention relates to an eukaryotic cell expressing nucleotide sequences encoding the ara A, ara B and ara D enzymes whereby the expression of these nucleotide sequences confers on the cell the ability to use L-arabinose and/or convert L-arabinose into L-ribulose, and/or xylulose 5-phosphate and/or into a desired fermentation product such as ethanol. Optionally, the eukaryotic cell is also able to convert xylose into ethanol. | 2010-04-08 |
20100086966 | FEEDBACK RESISTANT ACETOHYDROXY ACID SYNTHETHASE MUTANTS - The present invention provides nucleotide sequences coding for acetohydroxy acid synthetase (AHAS) mutants, the mutated enzymes themselves and a process for the fermentative production of branched-chain amino acids using these enzymes in specific hosts in which genes which code for the modified acetohydroxy acid synthetase (AHAS) are expressed. | 2010-04-08 |
20100086967 | CELL GROWTH - The invention concerns the field of cell culture technology. It concerns a method of improving cell growth, especially the growth of biopharmaceutical producer host cells. The invention further concerns a method of producing proteins using the cells generated by the described method. | 2010-04-08 |
20100086968 | LACTIC ACID BACTERIA STRAIN AND ITS USE FOR THE PROTECTION OF FOOD PRODUCTS - The present invention refers to a strain of | 2010-04-08 |
20100086969 | Antibodies That Bind to EphA2 and Methods of Use Thereof - Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using such antibodies directed against this antigen are also disclosed. | 2010-04-08 |
20100086970 | THERMUS SCOTODUCTUS NUCLEIC ACID POLYMERASES - The invention provides nucleic acids and polypeptides for a nucleic acid polymerase from a thermophilic organism, | 2010-04-08 |
20100086971 | GROWTH MEDIUM FOR CLOSTRIDIUM HISTOLYTICUM - The present invention provides improved media for the cultivation of | 2010-04-08 |
20100086972 | Process for the production of biodegradable, functionalised polymer particles and use thereof as pharmaceutical supports - The invention relates to a method for producing biodegradable, functionalised polymer particles, and to the use of the same as medicament carriers. | 2010-04-08 |
20100086973 | GLYCOSYLATE DERIVATIVES OF MITHRAMYCIN, METHOD OF PREPARATION AND USES THEREOF - The present invention provides compounds characterized by the formula (I), where each of the substituent radicals is described in the specification. The invention also describes the use of said compounds in the treatment of various diseases, including: cancer or tumoral processes in general, Paget's disease, hypercalcaemia, hypercalciuria and neurological diseases (inter alia, Parkinson's, Alzheimer's, Huntington's). | 2010-04-08 |
20100086974 | HIGHLY PURE POLYSIALIC ACID AND PROCESS FOR PREPERATION THEREOF - The instant invention provides highly pure Polysialic acid and process for preparation thereof. | 2010-04-08 |
20100086975 | METHOD AND APPARATUS FOR AMPLIFICATION OF NUCLEIC ACID SEQUENCES USING IMMOBILIZED DNA POLYMERASE - The present invention generally relates to methods and apparatuses for amplifying nucleic acid sequences using immobilized DNA polymerase. More particularly, it relates to methods and apparatuses useful for amplifying target nucleic acid sequences by forming a plurality of reaction regions in which polymerase chain reaction (PCR) can occur, positioning immobilized DNA polymerase in a specific reaction region, and circulating DNA through the reaction regions. The present invention provides those methods and apparatuses that allow simple separation and recovery of the DNA polymerase after the amplification, that can be operated not only with thermostable DNA polymerases but also with non-thermostable DNA polymerases, and that are simpler in their designs and processes so that they can be readily integrated into complex devices such as Lab-on-a-chip. | 2010-04-08 |
20100086976 | METHOD FOR DECONTAMINATING A SOLUTION WITH RESPECT TO UNWANTED NUCLEIC ACIDS - The present invention concerns a method for decontaminating a solution of any nucleic acid present in said solution, comprising the following steps:
| 2010-04-08 |
20100086977 | Pressure Chamber Clamp Mechanism - In a high-density sequence detection system, an apparatus for transporting a microplate. A control system provides a thermocycler control signal to regulate a desired thermal output of a thermocycler block. A frame has a first side, a second side, and an opening that extends through the first side and the second side. A window is positioned in the opening and a circumferential seal is positioned around a periphery of the opening at the second side. The seal has a peripheral lip that seals against the microplate. A clamp is adapted to engage and displace the frame from an unclamped position to a clamped position, wherein in the unclamped position, the microplate is displaced away from the thermocycler block and in the clamped position, the clamp urges the microplate against the thermocycler block. In some embodiments the peripheral lip is positioned radially inward of the periphery of the opening. | 2010-04-08 |
20100086978 | INCREASED ISOPRENE PRODUCTION USING THE ARCHAEAL LOWER MEVALONATE PATHWAY - The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene. | 2010-04-08 |
20100086979 | PRODUCTION OF OMEGA-3 FATTY ACIDS IN MICROFLORA OF THRAUSTOCHYTRIALES USING MODIFIED MEDIA - The present invention relates to improved methods for the production of omega-3 fatty acids by microorganisms belonging to the microflora of Thraustochytriales using a modified composition of the culture medium. In particular, the invention is directed to a process for the production of omega-3 fatty acids by culturing microflora, such as strains of | 2010-04-08 |
20100086980 | METHOD FOR PRODUCING LACTIC ACID - There is provided is a method for producing lactic acid from glycerol, which comprises culturing a specific bacterium capable of producing lactic acid in a culture medium containing glycerol, or making cells of the bacterium, processed cells of the bacterium or immobilized product thereof contact with glycerol. | 2010-04-08 |
20100086981 | COMPOSITIONS AND METHODS FOR IMPROVED SACCHARIFICATION OF BIOMASS - Compositions and methods are provided for enhancing saccharification of biomass with one or more enzymes to enhance availability of substrates for fermentation by a microorganism. Microorganisms are also modified to enhance activity of one or more hydrolytic enzymes that are present endogenously in or are introduced heterologously into a host microorganism. | 2010-04-08 |
20100086982 | PROCESS FOR THE BIOLOGICAL PRODUCTION OF n-BUTANOL WITH HIGH YIELD - The present invention provides a method for the biological production of n-butanol at high yield from a fermentable carbon source. In one aspect of the present invention, a process for the conversion of glucose to n-butanol is achieved by the use of a recombinant organism comprising a host | 2010-04-08 |
20100086983 | PROCESS FOR ACCELERATED CAPTURE OF CARBON DIOXIDE - The present invention generally relates to the removal of carbon dioxide from a gas stream, particularly a flue gas, hydrogen gas from a reformer, natural gas, or gas from a cement kiln. Immobilized enzymes for use in carbon capture and other systems are also disclosed. | 2010-04-08 |
20100086984 | OPTOINJECTION METHODS - Optoinjection method for transiently permeabilizing a target cell by (a) illuminating a population of cells contained in a frame; (b) detecting at least one property of light directed from the frame; (c) locating a target cell by the property of light; and (d) irradiating the target cell with a pulse of radiation. | 2010-04-08 |
20100086985 | NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 205P1B5 USEFUL IN TREATMENT AND DETECTION OF CANCER - A novel gene (designated 205P1B5) and its encoded protein are described. While 205P1B5 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in prostate cancer. Consequently, 205P1B5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 205P1B5 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response. | 2010-04-08 |
20100086986 | Nitrilases and Methods for Making and Using Them - The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature. | 2010-04-08 |
20100086987 | SURFACE TREATED CALCIUM CARBONATE AND ITS USE IN WASTE WATER TREATMENT - The present invention relates to a process for the purification of water, wherein a surface-reacted natural calcium carbonate is brought into contact with the water to be purified, the surface-reacted natural calcium carbonate being the reaction product of a natural calcium carbonate with an acid and carbon dioxide, which is formed in situ by the acid treatment and/or supplied externally. | 2010-04-08 |
20100086988 | NOVEL LACTIC ACID BACTERIA - The present invention relates to bacteria of a genus | 2010-04-08 |
20100086989 | MUTANT GLUCOSE DEHYDROGENASE - A mutant glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence of SEQ ID NO: 3 including substitution, deletion, insertion or addition of one or more amino acid residues other than the amino acid residue at the 365th position and having glucose dehydrogenase activity, wherein an amino acid residue at a position corresponding to the 365th position of, the amino acid sequence is replaced with another amino acid residue, and the mutant glucose dehydrogenase shows an improved substrate specificity to glucose. | 2010-04-08 |
20100086990 | APPARATUS AND METHOD FOR NUCLEIC ACID AMPLIFICATION - The present invention provides apparatus ( | 2010-04-08 |
20100086991 | INTEGRATED MICROFLUIDIC DEVICE WITH REDUCED PEAK POWER CONSUMPTION - An integrated microfluidic device having a number of chambers ( | 2010-04-08 |
20100086992 | BIOSENSOR, BIOSENSOR CHIP AND METHOD FOR PRODUCING THE BIOSENSOR CHIP FOR SENSING A TARGET MOLECULE - A biosensor chip for sensing a target molecule, includes: a substrate having a surface with a sensing area; and adhesive material for immobilizing a mollicute having a cell membrane on the sensing area. The chip may includes cell-resistant material for preventing the mollicute from being immobilized on those parts of the surface of the substrate that do not belong to the sensing area. Further, the adhesive material may comprise a first adhesive material for immobilizing a body of the mollicute on the sensing area and a second adhesive material for immobilizing a tip of the mollicute on the surface of the substrate. | 2010-04-08 |
20100086993 | CELL DETECTING SYSTEM AND QUANTUM DOT MEASURING SYSTEM - A cell detecting system is herein disclosed, wherein a complex is formed with a first bioactive ligand coupling to a quantum dot and recognizing and coupling to a first receptor of a cell and a second bioactive ligand coupling to a magnetic bead and recognizing and coupling to a second receptor of the cell. The magnet is configured for attracting the complex. A quantum dot measuring system configured for measuring the fluorescence of the complex includes an excitation light source, an optical system, a detecting sensor and a data capturing unit, wherein the detecting sensor includes a photomultiplier tube measuring florescence of the quantum dot excited by the excitation light source. The present invention achieves the goal of specific cell detection with high sensitivity without performing cell incubation. A quantum dot measuring system is also herein disclosed. | 2010-04-08 |
20100086994 | Structure of fermentation apparatus - A fermentation apparatus includes a fermentation tank, an air-hole mesh board, a lift-up cover, a blender and a pressurization equipment. An opening is above fermentation tank, an oblique-board base is at the bottom of the fermentation tank, and a feed opening and an air outlet are on the fermentation tank. Two air inlet holes are on the oblique-board base to form a passage through the oblique-board base. Exhaustion holes are on a surface of the oblique-board base and interconnected with the passage. The air-hole mesh board is installed in the fermentation tank and between the feed opening and the oblique-board base. The lift-up cover is connected to the fermentation tank and disposed above the fermentation tank for covering the opening. The blender is between the lift-up cover and the air-hole mesh board. The pressurization equipment is connected to the air inlet hole for supplying a high-pressure gas into fermentation tank. | 2010-04-08 |
20100086995 | MHC CLASS I PEPTIDE EPITOPES FROM THE HUMAN 5T4 TUMOR-ASSOCIATED ANTIGEN - There is provided an MHC class I peptide epitope from 5T4 antigen. In particular, there is provided a peptide epitope of 5T4 which comprises one of the following: (i) the amino acid sequence shown as SEQ ID No.2; (ii) the minimal epitope from the amino acid sequence shown as SEQ ID No.3; (iii) the minimal epitope from the amino acid sequence shown as SEQ ID No.4. (iv) the minimal epitope from the amino acid sequence shown as SEQ ID No. 5. (v) the minimal epitope from the amino acid sequence shown as SEQ ID No.6. (vi) the minimal epitope from the amino acid sequence shown as SEQ ID No.7. There is also provided a vaccine comprising such a peptide (or precursor thereof) and its use to treat and/or prevent a disease, in particular a cancerous disease. | 2010-04-08 |
20100086996 | GENETICALLY MODIFIED HUMAN NATURAL KILLER CELL LINES - The invention provides a natural killer cell, NK-92, modified to express an Fc receptor on the surface of the cell, such as CD16 (FcγRIII-A), or other Fcγ or Fc receptors. The modified NK-92 cell can be further modified to concurrently express an associated accessory signaling protein, such as FcεRI-γ, TCR-ζ, or to concurrently express interleukin-2 (IL-2) or other cytokines. Additional methods are disclosed for various assays, assessments, and therapeutic treatments with the modified NK-92 cells. | 2010-04-08 |
20100086997 | TrkB Agonists for Treating Autoimmune Disorders - Tyrosine receptor kinase (TrkB) agonists are provided for reducing leukocyte invasion of the central nervous system in autoimmune diseases such as multiple sclerosis. TrkB agonists include naturally-occurring agonists, such as NT4 and BDNF, as well as agonists such as agonist antibodies. | 2010-04-08 |
20100086998 | Enriched Central Nervous System Stem Cell and Progenitor Cell Populations, and Methods For Identifying, Isolating and Enriching For Such Populations - Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided. | 2010-04-08 |
20100086999 | DIFFERENTIATION OF PRIMATE PLURIPOTENT CELLS TO HEPATOCYTE-LINEAGE CELLS - Methods for differentiating primate pluripotent stem cells into hepatocyte-lineage cells are provided. In certain embodiments, the methods utilize sequential culturing of the primate pluripotent stem cells in certain growth factors to produce hepatocyte-lineage cells. In certain embodiments, the population of cells produced by the methods is further enriched for hepatocyte-lineage cells. | 2010-04-08 |
20100087000 | HEPATIC PROGENITOR CELL AND METHOD OF ISOLATING SAME - The isolation and proliferation of stem cells, particularly, hepatic stem cells continues to face technical hurdles. For example, colonies of stem cells, once isolated, tend to stop, or at least substantially slow, proliferating. The present invention provides a method to overcome this limitation, in part. The present invention also provides a method of providing and isolating a novel hepatic progenitor cell. | 2010-04-08 |
20100087001 | ANTI-ANGIOGENIC CELLULAR AGENT FOR CANCER THERAPY - The invention provides cytokine induced killer (CIK) cell populations and methods of using CIK cells to treat cellular proliferative disorders. CIK cells generated in vitro include both bulk cultures and clones. Individual CIK cell clones display distinct but overlapping lytic specificities for tumor cells and endothelial cells in vitro. When injected in vivo, bulk CIK cell cultures selectively attack tumor tissue. CIK cells can be used to treat a variety of cellular proliferative disorders, including early and late stage cancers as well as hematopoietic cell and solid tissue tumors. | 2010-04-08 |
20100087002 | Methods, Surface Modified Plates and Compositions for Cell Attachment, Cultivation and Detachment - The present invention relates to the field of mammalian cell culture, and provides methods and compositions for cell attachment to, cultivation on and detachment from a solid substrate surface containing from at least about 0.5% N, a sum of O and N of greater than or equal to 17.2% and a contact angle of at least about 13.9 degrees, lacking a feeder cell layer and lacking an adlayer. In one embodiment of the present invention, the cells are treated with a compound capable of inhibiting Rho kinase activity. In another embodiment, the cells are treated with a compound capable of inhibiting Rho activity. | 2010-04-08 |
20100087003 | DEVICE AND METHOD FOR THE MECHANICAL DECOLLATION OF CELLS FROM A CELL COMPOSITE - A device for mechanically decollating cells from a cell composite, particularly a shear rotor, a cell isolation unit including such a shear rotor and a method for decollating cells from a cell composite. The aforementioned device includes a rotor having a rotor wall, which is concentrically arranged in a receptacle. A rotor seat is connected to a motor and to which the rotor can be fixed in a detachable manner. A rotational movement of the motor can be transmitted to the rotor by means of the rotor seat. The rotor tapers longitudinally towards the bottom of the receptacle so that different circumferential speeds of the rotor can be transmitted to a liquid sample in the receptacle via the rotor wall. | 2010-04-08 |
20100087004 | PEPTIDE-PRESENTING SURFACES FOR LONG-TERM CULTURE OF PLURIPOTENT CELLS - The present invention relates to methods of growing and maintaining pluripotent cells on an insoluble substrate that presents a peptide that binds to glycosaminoglycans, such as heparin. Specifically, methods of growing and maintaining pluripotent cells on substrates having a chemically defined surface presenting at least one peptide having basic amino acid residues separated by one or two hydrophobic amino acid residues. | 2010-04-08 |
20100087005 | AUXILIARY REAGENT FOR GENE TRANSFER - The present invention provides a means for introducing a gene of interest into a host cell with a higher degree of efficiency regardless of the gene transfer method employed and the type of the host cell. The auxiliary reagent for gene transfer of the present invention is characterized in that it comprises a peptide comprising a specific amino acid sequence represented by formula (I), a mutant or derivative thereof, or a salt of the peptide, the mutant or the derivative. | 2010-04-08 |
20100087006 | Use of fluorescent protein in cyanobacteria and algae for improving photosynthesis and preventing cell damage - This disclosure provides a method to reduce cell damage caused by near UV light absorption of algal or cyanobacterial cultures. The algal or cyanobacterial cells are transformed to express one or more fluorescent proteins, that absorb the harmful UV or near UV wavelengths and emits wavelengths that are photosynthetically more active. The photosynthetic pigments of the transgenic algal or cyanobacterial cell culture will then absorb the photosynthetically active light emitted by the fluorescent proteins. Accordingly the harmful effects of the UV and near UV radiation are reduced and the photosynthetic activity of the algal or cyanobacterial cells is improved. | 2010-04-08 |
20100087007 | METHOD FOR QUANTITATIVE DETERMINATION OF NICKEL AND/OR COPPER AND EQUIPMENT TO BE USED IN THE METHOD - A method for quantitative determination of nickel and/or copper, by which an ultratrace amount of nickel and/or copper contained in a liquid sample can be easily and simply determined in situ; and apparatus to be used in the method. The method comprises a step of adding a complex-forming agent capable of forming a complex with nickel and copper to a liquid sample containing nickel and/or copper in unknown concentrations to form colored fine particles of a nickel complex and/or a copper complex and a step of determining the quantities of nickel and/or copper on the basis of the colored fine particles. | 2010-04-08 |
20100087008 | Materials and Methods for Isolating Phosphopeptides - Protein phosphorylation is a major post-translational modification and it plays a pivotal role in numerous cellular functions. We present a composition that includes a soluble nanopolymer core functionalized with groups having an affinity for either metal ion or metal oxides which can be used for phosphopeptide enrichment. Exemplary compounds including PolyMAC-Zr, PolyMAC-Fe and PolyMAC-Ti demonstrate outstanding reproducibility, exceptional sensitivity, fast chelation time, and high phosphopeptide recovery from standard mixtures that include phosphorylated peptides. The composition can be used for phosphoproteome isolation from samples of medicinal, diagnostic or biological interest such as malignant breast cancer cells. Such compositions were used for the quantitative analysis of the changes in the tyrosine phosphoproteome in highly invasive breast cancer cells after induction of Syk kinase, a potent suppressor of tumor growth and metastasis. The composition and method disclosed herein offers an efficient and widely applicable tool for phosphoproteomics. | 2010-04-08 |
20100087009 | Method for automated formulation process for production of radiopharmaceutical injection medicine and evaluation thereof - A method of automated formulation process for radiopharmaceutical injection medicine, including preparation for process control and calculation for formulation control, wherein the preparation steps for process control includes measuring radioactivity and size of radiopharmaceutical materials, determining measurement time and calibration time, measuring pH value and impurity percentage of radiopharmaceutical raw materials. By means of input of parameters measured and calculation of the volume of injection solvent and pH value, finished product of injection medicine is obtained when the pH value reaches 6.5, and the finished product is dispensed into the sterile bottles. | 2010-04-08 |
20100087010 | METHOD FOR MEASURING IMMUNOCHROMATO TEST PIECE - After dropping a sample onto an immunochromatographic test strip | 2010-04-08 |
20100087011 | Detection and/or Characterisation of Oligomers - Disclosed is a method of detecting the presence of an oligomer analyte in a liquid sample, the method comprising the steps of: (a) contacting a sample comprising the oligomer or aggregate with an oscillating sensor surface, which surface may optionally be coated with a receptor that binds directly or indirectly to at least one component of the oligomer or aggregate, so as to cause direct or indirect binding of the oligomer or aggregate to the surface; (b) using a detection circuit to measure or calculate at least two of the following parameters: series resonance frequency (f | 2010-04-08 |
20100087012 | Sample Collector and Processor - An aerosol sample collector with an air flow path comprising: (i) at a first segment thereof, a particle charging device, and (i) at a second segment thereof, deflection plates configured to focus particles of a desired charge into a preselected cross-section of the air flow path. The air flow path also includes charged substrates arranged at an outflow portion of the air flow path to collect charged particles on a collection surface of the charged substrates; and an exit path for flowing particles not in the preselected cross-section of the air flow path away from the charged substrates. Related methods are also provided. | 2010-04-08 |
20100087013 | Nanosensors and related technologies - The present invention generally relates to nanotechnology and sub-microelectronic circuitry, as well as associated methods and devices, for example, nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample (for example, their presence and/or dynamical information), e.g., at the single molecule level. For example, a nanoscale wire device can be used in some cases to detect single base mismatches within a nucleic acid (e.g., by determining association and/or dissociation rates). In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between a nucleic acid or other analyte, and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire, and the size of the second portion of the nanoscale wire may be minimized and/or controlled in some instances. Articles and devices of size greater than the nanoscale are also included in certain embodiments. Still other aspects of the invention include assays, sensors, kits, and/or other devices that include such nanoscale wires, methods of making and/or using such nanoscale wires, or the like. | 2010-04-08 |
20100087014 | HEAT TREATMENT APPARATUS AND METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - Provided is a heat treatment apparatus including a treatment chamber housing a silicon substrate, a heater being provided in the treatment chamber and heating the silicon substrate, and an atmosphere adjustment mechanism reducing a concentration of oxygen contained in an atmosphere inside the treatment chamber to less than an oxygen concentration in the air. The atmosphere adjustment mechanism is provided with an oxygen trap, for example. | 2010-04-08 |
20100087015 | FEEDBACK FOR BUFFER LAYER DEPOSITION - Improved methods and apparatus for forming thin film layers of chalcogenide on a substrate web. According to the present teachings, a feedback control system may be employed to measure one or more properties of the web and/or the chalcogenide layer, and to adjust one or more parameters of the system or buffer layer deposition method in response to the measurement. | 2010-04-08 |
20100087016 | APPARATUS AND METHODS FOR MANUFACTURING THIN-FILM SOLAR CELLS - Improved methods and apparatus for forming thin-film layers of semiconductor material absorber layers on a substrate web. According to the present teachings, a semiconductor layer may be formed in a multi-zone process whereby various layers are deposited sequentially onto a moving substrate web. | 2010-04-08 |
20100087017 | METHOD OF PRODUCING SEMICONDUCTOR DEVICE - It is intended to produce a semiconductor device with a stable gate length, using an end-point detection process based on monitoring a plasma emission intensity during dry etching for setting a gate length. A semiconductor device production method of the present invention comprises the steps of forming a first dielectric or gate conductive film to allow a pillar-shaped semiconductor layer to be buried therein; flattening the first dielectric or gate conductive film while detecting an end-point using a stopper formed on top of the pillar-shaped semiconductor layer; forming a second dielectric or gate conductive film; etching the second dielectric or gate conductive film and calculating an etching rate during the etching; and detecting an end-point of etching of the first dielectric or gate conductive film, based on the etching rate of the second dielectric or gate conductive film during etching-back of the second dielectric or gate conductive film, to control an etching amount of the first dielectric or gate conductive film. | 2010-04-08 |