14th week of 2014 patent applcation highlights part 43 |
Patent application number | Title | Published |
20140094348 | Self-Adjusting Skewer Clamp For A Bicycle Trainer - A self-adjusting bolt action skewer clamp for a bicycle trainer includes a hollow, outer support member and an inner engagement member located inside the support member. The support member has a helical slot with a pocket at one end. The inner engagement member is attached to a handle via a carrier contained within a passage defined by the inner engagement member, and the handle can slide within the helical slot such that the inner engagement member will extend past the support member as the handle is rotated around the helical slot. Once it reaches the pocket, the handle will remain locked in place. The clamp tightens onto a rear axle of the bicycle. The spring allows the bicycle trainer to accommodate bicycles of various sizes without adjustment. | 2014-04-03 |
20140094349 | Reverse Resistance Unit Mount For A Bicycle Trainer - A bicycle trainer includes a reverse resistance unit mounting arrangement that is configured to increase traction between a bicycle wheel and a resistance unit upon an increase in the speed of rotation of the wheel. The reverse resistance unit mounting arrangement is configured to mount the resistance unit in a suspension-type manner and has an actuator that initially positions the resistance unit against the bicycle wheel. The reverse resistance unit mounting arrangement tends to pivot the resistance unit against the bicycle wheel during use, to automatically bias the wheel toward the resistance unit to prevent slippage between the bicycle tire and the roller of the resistance unit. | 2014-04-03 |
20140094350 | PUNCHING BAG SUPPORT APPARATUS - This disclosure describes an apparatus and methods to support a punching bag, or a punching bag and rebound platform, within a doorway or other architectural opening. Mounting the apparatus does not involve modifying or altering the supporting architectural structures and surfaces (e.g., with screws, brackets, adhesives, etc.). Clamps are instrumental in safely securing the apparatus and stabilizing it for high-performance use of a plurality of punching bags. Adjustment mechanisms not only facilitate the mounting of the apparatus to a plurality of doorframes and other architraves but also accommodate the height and depth preferences of a user. In addition, a folding mechanism allows the apparatus to be compacted for storage or transport. | 2014-04-03 |
20140094351 | Resistance Brace - A resistance brace includes a pair of hinged arms having plates cooperating with one another to define a first and second pivots point separated from one another by a distance. A pair of splints having limb-attachment portions and geared ends engaged with one another and pivotably coupled with the plates at the pivot points. An adjustable compression member is coupled with the plates to compress the plates against the geared ends so as to frictionally impede movement of the splints relative to the plates. A joint harness is coupled with the hinged arms to attach the resistance brace to a joint of a body so that the hinged arms are positioned on opposing sides of the joint relative to a plane of rotation of the joint. Attachment members are coupled with the splints to attach the resistance brace to a first and second body portions extending from the joint. | 2014-04-03 |
20140094352 | FITNESS DEVICE - The present invention provides methods and systems for a fitness device that includes a frame having a horizontal portion and a vertical portion that are hingedly connected, a back engaged to the vertical portion of the frame, a seat engaged to the horizontal portion of the frame, and two pairs of legs extending away from the horizontal portion of the frame for positioning the fitness device on a surface. | 2014-04-03 |
20140094353 | PRESSURE SEALING SYSTEM - The present invention discloses a sealing system for sealing together at least a pair of flexible pouch material layers. The sealing station can have a first sealing bar, a second sealing bar and a drive system that is in contact with the first sealing bar. The drive system is operable to move the first sealing bar between an open position and a closed position such that the first sealing bar can apply a predefined pressure on the flexible pouch material layers when positioned or located between the sealing bars. A pressure sensor is also included and in communication with the drive system, the pressure sensor operable to detect if the drive system applies less or too much pressure than the predefined pressure on the flexible pouch material layers located between the first and second sealing bars. | 2014-04-03 |
20140094354 | Tape monitoring system - In general, the present invention comprises of a control unit with a tape applicator with operative members to selectively actuate sensors of a multiple sensor arrangement each of which is positioned to detect movement or position caused by a carton or the dispensing tape; specifically, the signal caused by the present of the carton; the movement caused by the dispensing tape as the carton being taped, and a further signal actuated based on the size (depletion) of the dispensing tape roll. The detected signals from the sensors are sent to a control unit with a multiple timing circuit or a preprogrammed micro processor with predetermined sequences and time values to generate and emit a correspond alarm signal based on the following control logics. | 2014-04-03 |
20140094355 | METHOD FOR PRODUCING SILICON CARBIDE-CARBON COMPOSITE - Provided is a novel method for producing a silicon carbide-carbon composite. A green body containing a carbonaceous material | 2014-04-03 |
20140094356 | TREATMENT PROCESS, OXIDE-FORMING TREATMENT COMPOSITION, AND TREATED COMPONENT - A treatment process, an oxide-forming treatment composition, and a treated component are disclosed. The treatment process includes applying an oxide-forming treatment composition to a ceramic coating and heating the oxide-forming treatment composition to form an oxide within the ceramic coating. The oxide-forming treatment composition includes a solute and a corrosion inhibitor. The oxide-forming treatment composition is super-saturated with the corrosion inhibitor. The treated component includes a ceramic coating and one or both of a corrosion inhibitor and an oxide formed by an oxide-forming treatment composition having the corrosion inhibitor. The corrosion inhibitor and the oxide-forming treatment composition are within the ceramic coating. | 2014-04-03 |
20140094357 | METHOD OF MANUFACTURING TRANSPARENT SESQUIOXIDE SINTERED BODY, AND TRANSPARENT SESQUIOXIDE SINTERED BODY MANUFACTURED BY THE METHOD - Provided is a method of manufacturing a transparent sesquioxide sintered body by which a transparent M | 2014-04-03 |
20140094358 | METHOD OF FORMING CERAMIC ARTICLES FROM RECYCLED ALUMINOSILICATES - The present invention relates to a process of forming ceramic articles that contain a high percentage of recycled alumina silicate in their composition. The fabrication process includes a fusing of the base material forming a reticulated network that is in-filled with a melted additive composition. The base material gives the article dimensional stability and strength while the additive composition gives the article water resistance and toughness In this invention, an additive powder with an engineered melting temperature is added to the recycled base material. The mixture is heated until the recycled aluminosilicate reaches the optimal fusing temperature. Heating is continued until the additive begins to melt filling the voids between the fused aluminosilicates particles. The article is then rapidly cooled to quench the fusing without cracking. The resulting article has high strength due to the fused alumina silicate particles and low water absorbance and high density due to the melted additive component filling all the pores between the fused alumina silicate particles. | 2014-04-03 |
20140094359 | GAS SEPARATION ADSORBENTS AND MANUFACTURING METHOD - The present invention generally relates to high rate adsorbents and a method for their manufacture involving the steps of component mixing, extrusion, spheronization and calcination. The component mixing can involve both dry mixing in addition to wet mixing of an adsorbent with a binder, if required, and a fluid such as water. The paste so formed from the mixing stage is extruded to produce pellets which are optionally converted to beads by spheronization using in one embodiment, a marumerizer. The product is harvested and calcined to set any binder or binders used and/or burn out any additives or processing aids. This basic manufacturing scheme can be augmented by extra processing steps including ion exchange and activation to alter the composition of the adsorbents, as required. | 2014-04-03 |
20140094360 | REACTIVE EXTRACTION PROCESS FOR REGENERATION OF AMINE-BASED SOLVENTS USED FOR CARBON DIOXIDE CAPTURE - A method for recovery of impurities and/or degradation products and/or heat-stable salts from amine-based solvents used for capture of C0 | 2014-04-03 |
20140094361 | ABSORBENT STRUCTURE - An absorbent structure with a sequence of two layers includes at least one liquid absorption layer, a subsequent liquid storage layer with super absorbent polymer particles and super absorbent polymer fibers, and a subsequent liquid distribution layer. The layers are connected and form a sheet structure. The liquid storage layer has its super absorbent polymer extending from the liquid storage layer into the liquid distribution layer in order to generate a return suction effect for the liquid that has passed through the liquid absorption layer and liquid storage layer into the liquid distribution layer. | 2014-04-03 |
20140094362 | TRIAZOLE COMPOUND AND USE THEREOF - In order to provide a compound that shows a strong effect on controlling a plant disease, a triazole compound of the present invention (i) is a compound in which —OH group, —R | 2014-04-03 |
20140094363 | Active Substance for Increasing Pathogenic Defense in Plants and Methods for the Defection Thereof - The invention relates to a method for finding compounds which induce plant pathogen defense, the enhanced expression of individual, or a plurality of, endogenous plant genes from the group consisting of jasmonic acid biosynthesis, plant proteinase inhibitors, plant xylanase inhibitors, plant PR proteins (pathogen-related proteins) and plant chitinases being regarded as a sign that induction has taken place, and to the use of these compounds alone or in combination with known compounds which act specifically and directly against phytopathogens, it being possible to carry out the application either simultaneously or staggered. | 2014-04-03 |
20140094364 | SYNERGISTIC WEED CONTROL FROM APPLICATIONS OF AMINOCYCLOPYRACHLOR AND AMINOPYRALID - Disclosed herein are herbicidal compositions comprising a synergistically herbicidal effective amount of (a) aminocyclopyrachlor, or an agriculturally acceptable salt or ester thereof, and (b) aminopyralid, or an agriculturally acceptable salt or ester thereof. Also disclosed herein are methods of controlling undesirable vegetation, which comprise applying to vegetation or an area adjacent the vegetation or applying to soil or water to prevent the emergence or growth of vegetation (a) aminocyclopyrachlor, or an agriculturally acceptable salt or ester thereof, and (b) aminopyralid, or an agriculturally acceptable salt or ester thereof, wherein (a) and (b) are each added in an amount sufficient to produce a synergistic herbicidal effect. | 2014-04-03 |
20140094365 | SYNERGISTIC WEED CONTROL FROM APPLICATIONS OF AMINOCYCLOPYRACHLOR AND TRICLOPYR - Disclosed herein are herbicidal compositions comprising a synergistically herbicidal effective amount of (a) aminocyclopyrachlor, or an agriculturally acceptable salt or ester thereof, and (b) triclopyr, or an agriculturally acceptable salt or ester thereof. Also disclosed herein are methods of controlling undesirable vegetation, which comprise applying to vegetation or an area adjacent the vegetation or applying to soil or water to prevent the emergence or growth of vegetation (a) aminocyclopyrachlor, or an agriculturally acceptable salt or ester thereof, and (b) triclopyr, or an agriculturally acceptable salt or ester thereof, wherein (a) and (b) are each added in an amount sufficient to produce a synergistic herbicidal effect. | 2014-04-03 |
20140094366 | SYNERGISTIC WEED CONTROL FROM APPLICATIONS OF AMINOCYCLOPYRACHLOR AND FLUROXYPYR - Disclosed herein are herbicidal compositions comprising a synergistically herbicidal effective amount of (a) aminocyclopyrachlor, or an agriculturally acceptable salt or ester thereof, and (b) fluoroxypyr, or an agriculturally acceptable salt or ester thereof. Also disclosed herein are methods of controlling undesirable vegetation, which comprise applying to vegetation or an area adjacent the vegetation or applying to soil or water to prevent the emergence or growth of vegetation (a) aminocyclopyrachlor, or an agriculturally acceptable salt or ester thereof, and (b) fluoroxypyr, or an agriculturally acceptable salt or ester thereof, wherein (a) and (b) are each added in an amount sufficient to produce a synergistic herbicidal effect. | 2014-04-03 |
20140094367 | METHOD OF IMPROVING GRASS QUALITY - The invention relates to a method of improving grass quality comprising applying an effective amount of a composition containing a phthalocyanine to the grass in the substantial absence of phosphorous acid, monoalkyl esters of phosphorous acid, or salts thereof. | 2014-04-03 |
20140094368 | Substituted Pyridines Having Herbicidal Activity - The present invention provides substituted pyridine compounds of the formula I | 2014-04-03 |
20140094369 | DELIVERY OF ETHYLENE BLOCKING AND/OR PROMOTING AGENTS - A composition including an ethylene blocking agent complex formed from the product of an ethylene blocking agent and a host, and at least one water-soluble polymer, wherein the ethylene blocking agent complex and the at least one water-soluble polymer are intermingled is disclosed. | 2014-04-03 |
20140094370 | FORMULATION COMPONENT - The invention relates to the use of aromatic esters as adjuvants in compositions, particularly for agrochemical use, as well to compositions comprising such an aromatic ester, in combination with at least one agrochemical. The invention further extends to methods of making and using such compositions. In particular the present invention relates to such compositions when formulated as, or comprised by, an emulsion concentrate (EC), an emulsion in water (EW), a suspension of particles in water (SC), a microcapsule formulation (CS), a suspension of particles with and emulsion (SE), a dispersion concentrate (DC) or an oil suspension (OD). | 2014-04-03 |
20140094371 | MAGNETIC SHIMS TO ALTER MAGNETIC FIELDS - An example particle accelerator includes a coil to provide a magnetic field to a cavity; a cryostat comprising a chamber for holding the coil, where the coil is arranged in the chamber to define an interior region of the coil and an exterior region of the coil; magnetic structures adjacent to the cryostat, where the magnetic structures have one or more slots at least part-way therethrough; and one or more magnetic shims in one or more corresponding slots. The one or more magnetic shims are movable to adjust a position of the coil by changing a magnetic field produced by the magnetic structures. | 2014-04-03 |
20140094372 | COMPACTLY-INTEGRATED OPTICAL DETECTORS AND ASSOCIATED SYSTEMS AND METHODS - Compactly-integrated electronic structures and associated systems and methods are provided. Certain embodiments relate to the ability to integrate nanowire-based detectors with optical components. | 2014-04-03 |
20140094373 | HIGHLY MULTIPLEX PCR METHODS AND COMPOSITIONS - The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons. | 2014-04-03 |
20140094374 | Recombinant Polymerases with Increased Readlength and Stability for Single-Molecule Sequencing - Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing or nucleic acid amplification. Such properties include increased stability, increased readlength, enhanced performance with large nucleotide analogs, and improved detection of modified bases, and can also include resistance to photodamage, enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased accuracy, altered speed, increased cosolvent resistance, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. | 2014-04-03 |
20140094375 | Recombinant Polymerases for Incorporation of Protein Shield Nucleotide Analogs - Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing or nucleic acid amplification. Such properties include enhanced performance with large nucleotide analogs, increased stability, increased readlength, and improved detection of modified bases, and can also include resistance to photodamage, enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased accuracy, altered speed, increased cosolvent resistance, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. | 2014-04-03 |
20140094376 | MULTIPLEX PYROSEQUENCING USING NON-INTERFERING NOISE CANCELLING POLYNUCLEOTIDE IDENTIFICATION TAGS - The present disclosure generally pertains to a multiplex method for analyzing samples comprising using polynucleotide amplification to produce amplified products wherein one or more target sequences are tagged with a non-interfering, non-canceling target-specific polynucleotide identification tag, pyrosequencing the amplified products through the non-canceling target-specific polynucleotide identification tag sequence to detect the presence of one or more specific polynucleotide identification tags. The presence of a specific polynucleotide identification tag being correlated with the presence of a specific target sequence. | 2014-04-03 |
20140094377 | METHOD FOR MUTIPLEXED MICROFLUIDIC BEAD-BASED IMMUNOASSAY - A method for performing multiplexed bead-based immunoassays using a microfluidic cassette capable of detecting a particle passing in substantially single file through an interrogation zone and generating a Coulter effect signal responsive to a characteristic of the particle. A fluid sample may be prepared by associating antibody-coated beads of different sizes to particles of interest. A first multiplexing option may be based on bead size, in which case the intensity of the Coulter signal is used to sort or characterize the particles. A second multiplexing option may be based on detection of Stokes' shift phenomena, or even simply emission intensity, in which case particles may be characterized responsive to intensity of the signal resulting from detection of radiation. The first and second multiplexing options may be employed together to populate an array of particle characteristics. | 2014-04-03 |
20140094378 | MEANS AND METHODS FOR CLASSIFYING SAMPLES OF MULTIPLE SCLEROSIS PATIENTS - The invention in one aspect provides a method for classifying cells from a human individual said method comprising: providing a sample comprising cells from said individual that are typically responsive to exposure to a type I interferon; determining a level of activity of a pathway that is modulated by type I interferon; and classifying said cells on the basis of the determined level of activity. Cells present in said sample are preferably cultured said cells in the presence of a type I interferon prior to determining a level of activity of said pathway. This is activity is preferably compared to the activity of said pathway in cells in said sample prior to said culture. Preferably the sample is from an individual that is not treated with a type I interferon prior to collecting said sample. Preferably the method is used to determine, prior to initiating treatment with a type I interferon, whether said individual is likely to be a good, a normal or a poor responder to the contemplated treatment. | 2014-04-03 |
20140094379 | Colon Cancer Gene Expression Signatures and Methods of Use - A gene expression signature of colon cancer, microarrays including them and methods of using the colon gene expression signature are provided. The gene expression signature is especially useful for determining the prognosis of a patient diagnosed with colon cancer, such as stage II colon cancer. The gene signature described herein is also useful for determining effectiveness of surgical resection with or without adjuvant chemotherapy, and determining possibility of cancer recurrence in patients with colon cancer. | 2014-04-03 |
20140094380 | Methylation Biomarkers for Diagnosis of Prostate Cancer - Biomarkers for diagnosis and prognosis of prostate cancer are provided. The biomarkers are promoter sequences have altered methylation patterns relative to normal prostate tissue. Altered expression of DNA methyltransferases (DNMT) and proteins that interact with DNMT result in increased methylation at a subset of prostate tumor hypermethylation sites. | 2014-04-03 |
20140094381 | Predictive Biomarkers for Response to Exercise - A set of biomarkers have been identified that allows one to predict subjects who will respond to an exercise regime in term of cardiorespiratory fitness as assessed by maximal oxygen uptake. These predictions may be used, for example, to predict risk of cardiovascular disease, to design a more effective program for cardiac rehabilitation, to predict capacity for athletic performance or physically demanding occupation, and to predict ability to maintain functional capacity with aging using exercise. | 2014-04-03 |
20140094382 | METHODS AND AGENTS FOR MODULATING PROTOCADHERIN-18 ACTIVITY - Screening assays and methods of using same for screening to identify modulator agents or compounds that affect pcdh18 mediated inhibition of T cell effector function are described herein. Pharmaceutical and immunogenic compositions comprising agents or compounds that modulate pcdh18 mediated inhibition of T cell effector function are also encompassed. Methods for modulating pcdh18 mediated inhibition of T cell effector function using agents identified using assays described herein in pharmaceutical and immunogenic compositions are also envisioned. Adenocarcinoma is an exemplary tumor type that expresses pcdh18 and for which such pharmaceutical and immunogenic compositions would confer benefit to patients. Also encompassed are methods for reducing pcdh18 mediated inhibition of T cell effector function so as to achieve more effective T cell responses to pcdh18 expressing tumors. | 2014-04-03 |
20140094383 | Tethered Lipoplex nanoparticle Biochips And Methods Of Use - Disclosed are compositions and methods for the use of lipoplex nanoparticle chips and arrays in the detection of/diagnosis of a disease or condition. | 2014-04-03 |
20140094384 | STROMAL ANTIGEN 2 (STAG2) COMPOSITIONS AND METHODS - Compositions and methods related to stromal antigen 2 (STAG2) and its role in diverse human cancers, including nucleic acids, polypeptides, vectors, cells and cell lines. | 2014-04-03 |
20140094385 | SEQUENCE-SPECIFIC ENGINEERED RIBONUCLEASE H AND THE METHOD FOR DETERMINING THE SEQUENCE PREFERENCE OF DNA-RNA HYBRID BINDING PROTEINS - The subject of the invention is the ribonuclease which cleaves RNA strand in DNA-RNA hybrids, wherein ribonuclease comprises fusion protein comprising catalytic domain of RNase HI (RNase HI) or derivative thereof with a zinc finger DNA-RNA hybrid binding domain, and wherein the zinc finger binding domain has the ability to bind to specific sequences in the DNA-RNA hybrid. The invention also relates to new methods for determination of the sequence preference of DNA-RNA hybrid binding protein(s) or its domain(s) and allows determining the sequence recognized by sequence specific binding protein in the DNA-RNA hybrid. | 2014-04-03 |
20140094386 | METHODS OF DETERMINING A TREATMENT PROTOCOL FOR AND/OR A PROGNOSIS OF A PATIENT'S RECOVERY FROM A BRAIN INJURY RESULTING FROM A HYPOXIC EVENT - The present invention, in some embodiments, generally relates to methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury resulting from a hypoxic event. In some embodiments, methods are provided for determining a measure of the concentration of beta-amyloid peptide in a patient sample containing or suspected of containing beta-amyloid peptide. | 2014-04-03 |
20140094387 | SUV39H2 AS A TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS - Objective methods for detecting or diagnosing cancer, or determining a predisposition for developing cancer, particularly lung cancer, cervical cancer, bladder cancer, esophageal cancer, osteosarcoma, prostate cancer and soft tissue tumor, are described herein. In one embodiment, the diagnostic method involves determining an expression level of the SUV39H2 gene. The present invention further provides methods of screening for candidate substances useful in the treatment and/or prevention of an SUV39H2-associated cancer, such as lung cancer, cervical cancer, bladder cancer, esophageal cancer, osteosarcoma, prostate cancer and soft tissue tumor. The present invention further provides methods of inhibiting the cell growth and thereby treating or alleviating symptoms of an SUV39H2 associated cancer. The present invention also features double-stranded molecules against the SUV39H2 gene and vectors encoding thereof as well as compositions containing such components and their utility in connection with the treatment and prevention of an SUV39H2-associated cancer. | 2014-04-03 |
20140094388 | Engineered Cardiac Tissues and Methods of Using Them - Engineered cardiac tissues are provided herein. The tissues include cardiomyocyte cells derived from a pluripotent cell, fibroblast cells and extracellular matrix components. Methods of using the tissues described herein are also provided. | 2014-04-03 |
20140094389 | COMPOSITIONS AND METHODS FOR DETECTING PREDISPOSITION TO A SUBSTANCE USE DISORDER - The present invention provides screening kits, compositions, and diagnostic methods for determining whether a subject has a predisposition to, or likelihood of having, a substance use disorder by determining a nucleic acid methylation profile from a biological sample from the subject, wherein a given profile indicates that the subject has a predisposition to a substance use disorder. | 2014-04-03 |
20140094390 | siRNA Targeting TIE-2 - Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed. | 2014-04-03 |
20140094391 | BIO-NANO-CHIPS FOR ON-SITE DRUG SCREENING - A bio-nano-chip (BNC) technology that works in connection with non-invasive samples, such as saliva, cheek swab or urine samples that can be easily performed by non-specialists, such as security personnel and police officers is disclosed. The microfluidic system for drug testing includes an analyzer or reader having a housing containing a slot for receiving a cartridge, a drug testing cartridge, a processor having a user interface, an optical or energy sensing means, and a means for moving fluid. | 2014-04-03 |
20140094392 | METHODS OF GENERATING LIBRARIES AND USES THEREOF - This invention relates to methods for the generation of humanized antibodies, particularly a humanized antibody heavy chain protein and a humanized antibody light chain protein. The method comprises using cells that express or can be induced to express Activation Induced Cytidine Deaminase (AID). | 2014-04-03 |
20140094393 | COMPOSITION AND METHOD FOR REDUCING HYDRATE AGGLOMERATION - Compositions and methods of inhibiting the formation of hydrate agglomerates in fluids including water, gas, and optionally liquid hydrocarbons are disclosed. The compositions may include counterions, such as halides or carboxylates. The compositions may also include a thermodynamic hydrate inhibitor, a kinetic hydrate inhibitor, an additional anti-agglomerant, an asphaltene inhibitor, a paraffin inhibitor, a corrosion inhibitor, a scale inhibitor, an emulsifier, a water clarifier, a dispersant, an emulsion breaker, and combinations thereof. | 2014-04-03 |
20140094394 | High Density Weight Materials for Oil Field Servicing Operations - A wellbore treatment fluid comprising one or more high-density weighting materials selected from the group consisting of tungsten-containing materials, bismuth-containing materials, and tin-containing materials. | 2014-04-03 |
20140094395 | RINSE-OFF SKIN CARE COMPOSITIONS CONTAINING ALKYL AMIDOPROPYL BETAINE SURFACTANTS - The compositions of this invention relate to rinse-off skin care compositions containing alkyl amidopropyl betaine surfactants having rheological properties acceptable to the user. The rinse-off skin care cleansing compositions of the invention preferably contain no greater than about 3% anionic surfactant by weight of the composition; no greater than about 3% of an alkyl amidopropyl betaine having from 8 to 10 carbon atoms in the alkyl chain; no greater than 8% by weight of unsaturated alkyl amidopropyl betaines having at least 18 carbon atoms; and at least one amphoteric surfactant. | 2014-04-03 |
20140094396 | PROCESS TO PREPARE AN EXTERNAL STRUCTURING SYSTEM FOR LIQUID LAUNDRY DETERGENT COMPOSITION - The present invention relates to a process to prepare external structuring system(s) (ESS) comprising crystallized triglycerides including crystallized hydrogenated castor oil (HCO) and packing parameter adjusting agent to provide higher structuring ability. The present invention also relates to laundry detergent compositions in liquid or gel form comprising ESS. | 2014-04-03 |
20140094397 | External structuring system for liquid laundry detergent composition - The present invention relates to external structuring system(s) (ESS) comprising crystallized triglycerides including crystallized hydrogenated castor oil (HCO), surfactant and organic non-amino functional alcohols to reduce shear sensitivity. The present invention also relates to laundry detergent compositions in liquid or gel form comprising ESS. | 2014-04-03 |
20140094398 | STABLE ENZYME STABILIZER PREMIX - The need for a highly concentrated enzyme stabilizer premix, which is both physically and chemically stable, is met by dissolving phenyl boronic acid, or a derivative thereof, to form a premix comprising an organic solvent, while limiting the amount of water present. | 2014-04-03 |
20140094399 | BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF - Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. | 2014-04-03 |
20140094400 | Novel Angiotensin Type 2 (AT2) Receptor Agonists and Uses Thereof - The invention relates to novel pharmaceutically-useful peptides, in particular cyclic peptides that are agonists of the AngII type 2 receptor (AT2 receptor). The invention further relates to the use of such peptides as medicaments, to pharmaceutical compositions containing them, and to their production. | 2014-04-03 |
20140094401 | MITRECIN A POLYPEPTIDE WITH ANTIMICROBIAL ACTIVITY - The present invention provides a Mitrecin A polypeptide useful in prevention and treatment of one or more bacteria. Also provided is a method to kill or prevent growth of one or more bacteria comprising contacting the one or more bacteria with a Mitrecin A polypeptide. The target bacteria can be selected from the group consisting of a Gram-positive bacterium, a Gram-negative bacterium, or both. In one embodiment, the present invention is drawn to a polynucleotide encoding a Mitrecin A polypeptide, a vector comprising the polynucleotide, a host cell comprising the polynucleotide, or a composition comprising the Mitrecin A polypeptide, the polynucleotide, the vector, or the host cell. | 2014-04-03 |
20140094402 | Lantibiotic NAI-802, Pharmaceutically Acceptable Salts, Compositions and Uses Thereof - The present invention concerns novel lantibiotic compounds, processes for the isolation and preparation thereof, pharmaceutical compositions containing the same, pharmaceutical acceptable salts thereof, and methods of use of the lantibiotics as antibacterial agents. | 2014-04-03 |
20140094403 | ENOPEPTINS, USES THEREOF, AND METHODS OF SYNTHESIS THERETO - Provided herein are inventive enopeptin compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Further provided are methods of preparation, use, and treatment. | 2014-04-03 |
20140094404 | METHODS AND REAGENTS FOR EFFICIENT AND TARGETED DELIVERY OF THERAPEUTIC MOLECULES TO CXCR4 CELLS - The invention relates to conjugates comprising a targeting moiety specific for the CXCR4 based on the polyphemusin-derived peptide and a therapeutic or imaging agent. The invention relates as well to the application of said conjugates for the therapy and diagnostics which require the specific targeting to CXCR4+ cells. | 2014-04-03 |
20140094405 | CHOLESTEROL DERIVATIVES OF INHIBITORS OF VIRAL FUSION - The present invention relates to compounds comprising at least ten contiguous amino acids of the HR2 domain of a Type 1 viral fusogenic protein of an enveloped virus, or a derivative thereof, attached at the C-terminal to cholesterol or a derivative thereof; or a pharmaceutically acceptable salt thereof which inhibit viral fusion. Thus compounds of the invention are useful to prevent or treat diseases caused by an enveloped virus. | 2014-04-03 |
20140094406 | CHIMERIC FIBROBLAST GROWTH FACTOR 21 PROTEINS AND METHODS OF USE - The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor (“FGF”) and the C-terminus includes a C-terminal portion of an FGF21 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from diabetes, obesity, or metabolic syndrome, and methods of screening for compounds with enhanced binding affinity for the βKlotho-FGF receptor complex involving the use of chimeric proteins of the present invention. | 2014-04-03 |
20140094407 | DEVICES AND METHODS FOR TREATING AND/OR PREVENTING DISEASES - The invention relates to a therapeutic device for the delivery of therapeutic agents, e.g. a peptide such as leuprolide, via the vagina to a female mammal. In some embodiments, the invention also relates to methods for the treatment of obesity and eating disorders, diabetes, multiple sclerosis (MS), endometriosis, uterine fibroids, polycystic ovarian disease, various cancers such as breast cancer, acne, hirsutism, microbial or fungal or viral infections such as bacterial vaginosis or AIDS/HIV, and chronic diseases using a disclosed vaginal device. | 2014-04-03 |
20140094408 | MEDICAMENT FOR TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS, HYPERTENSION AND/OR METABOLIC SYNDROME - A dietary supplement or medicament comprising a substance including the chemical structure of bicyclo [3.2.1]octan or the chemical structure of kaurene. The medicament is useful for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome. The possible substances include steviol, isosteviol or stevioside. | 2014-04-03 |
20140094409 | ANTAGONIST FOR (PRO)RENIN RECEPTOR FOR THE TREATMENT OF HYPERTENSION AND DIABETES - Brain prorenin and the (pro)renin receptor (PRR) have a functional role in the development of hypertension. The present disclosure presents functional PRR antagonistic peptides (e.g., PR10, PR20, PR30, and PR40). In addition, modified peptides comprising one or more thioether-bridges that are stable and strong PRR antagonists are also provided. Methods for treating and preventing hypertension, including neurogenic hypertension, and diabetes with a PRR antagonist are also provided. | 2014-04-03 |
20140094410 | SILK FIBROIN MATERIALS AND USE THEREOF - The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided. | 2014-04-03 |
20140094411 | METHOD OF PURIFYING PROTEINS - The present invention relates generally to a method of purifying proteins. More specifically, the present inventions relates to a method of purifying haptoglobin and hemopexin from the same starting material, and uses thereof. | 2014-04-03 |
20140094412 | SELECTIVE ALFAVBETA3 RECEPTOR PEPTIDE ANTAGONIST FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The present invention is related to new peptide antagonists of α | 2014-04-03 |
20140094413 | HEPATOCYTE GROWTH FACTOR (HGF) MIMICS AS THERAPEUTIC AGENTS - Small molecule, peptidic hepatocyte growth factors mimics, which act as both mimetics and antagonists, have been generated. These molecules have been shown or predicted to have therapeutic potential for numerous pathologies including dementia, Alzheimer's disease, Parkinson's disease, amyotrphic lateral sclerosis, and other neurodegenerative diseases, spinal cord injury, traumatic brain injury, diabetes and metabolic syndrome, cancer, and defective wound healing. | 2014-04-03 |
20140094414 | COMPOSITION FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASE INCLUDING BIOACTIVE PEPTIDE AS EFFECTIVE COMPONENT - There is provided a new use of protein hydrolysates and peptide derived from seahorses for preventing or treating a neurodegenerative disease, and more particularly a composition and health functional foods for preventing or treating a neurodegenerative disease including seahorse protein hydrolysates or peptide isolated and purified from the same as an effective component. | 2014-04-03 |
20140094415 | HIGH-AFFINITY, DIMERIC INHIBITORS OF PSD-95 AS EFFICIENT NEUROPROTECTANTS AGAINST ISCHEMIC BRAIN DAMAGE AND FOR TREATMENT OF PAIN - The invention provides novel potent inhibitors of the ternary protein complex of nNOS, PSD-95, and the NMDA receptor and pharmaceutical compositions comprising the inhibitors for prophylaxis and/or treatment of excitotoxic-related disease and chronic pain conditions in a subject. The inhibitors are dimeric PSD-95 inhibitors comprising a first peptide or peptide analogue linked to a second peptide or peptide analogue by a linker, wherein the first and the second peptide or peptide analogue comprise at least four amide-bonded residues having a sequence YTXV or YSXV, wherein a. Y is selected from among E, Q, and A, or an analogue thereof, and b. X is selected from among A, Q, D, N,N-Me-A, N-Me-Q, N-Me-D, and N-Me-N or an analogue thereof, and wherein a Cell Penetrating Peptide (CPP) is linked to the linker or to an amino acid side chain of the first and second peptide or peptide analogue. The linker can be a PEG or NPEG linker. | 2014-04-03 |
20140094416 | SPARC ANGIOGENIC DOMAIN AND METHODS OF USE - The invention provides compositions and methods which exploit the discovery of the SPARC carboxy angiogenic domain. | 2014-04-03 |
20140094417 | PSEUDOMONAS EXOTOXIN A WITH LESS IMMUNOGENIC T CELL AND/OR B CELL EPITOPES - The invention provides a | 2014-04-03 |
20140094418 | PALATABLE DUCTILE CHEWABLE VETERINARY COMPOSITION - The present invention is directed to palatable ductile chewable veterinary composition for oral administration. The composition is capable of killing endo-parasites and ecto-parasites and/or can be used for treating prophylactic or curative animal diseases, and it is useful for the treatment of any warm-blooded non-human animal, including herd animals, like horses, cattle, sheep or poultry and preferably pets like dogs and cats. It consists basically of (A) an effective amount of one or more ingredients that are active against animal pests, pathogens or animal diseases; (B) meat flavoring; (C) partially gelatinized starch; (D) a softener; and (E) up to 9% water. | 2014-04-03 |
20140094419 | INJECTABLE AQUEOUS OPHTHALMIC COMPOSITION AND METHOD OF USE THEREFOR - The present invention is directed to the provision of an ophthalmic composition suitable for intravitreal injection. The composition includes an amount of complexing agent that reacts with one or more endogenous components (e.g., hyaluronic acid) in the eye to form a mass of enhanced viscosity. This mass can aid in creating a desirable release profile of therapeutic agent. | 2014-04-03 |
20140094420 | HYDROGEL-FORMING MATERIAL - There is provided a hydrogel-forming material from which a hydrogel can be formed with a simpler method and under milder conditions. A hydrogel-forming material comprising a lipid peptide-type gelator that is formed of at least one selected from compound of the following formula (1): | 2014-04-03 |
20140094421 | HERBAL MEDICINAL COMPOSITION FOR TREATMENT OF WOMEN INFERTILITY AND A METHOD OF PREPARING THE SAME - The embodiments herein provide a herbal medicinal composition for effectively treating a women infertility and a method for preparing the same. The composition comprises elm tree wood, a camel fat and water. The composition is prepared by taking several pieces of elm tree wood in a container and adding camel fat and water to the container. The container is heated for 120 minutes. The color of the contents of the container changes to bright red upon boiling. The mixture is filtered and cooled down at room temperature. The composition is taken by a patient in the morning for at least first seven days of the menstrual cycle. | 2014-04-03 |
20140094422 | Triazole Compounds and Methods of Making and Using the Same - The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. These compounds are represented by the following formula (I): | 2014-04-03 |
20140094423 | AQUEOUS HAIR CLEANSING AGENT - An aqueous hair cleansing agent contains a sulfate-type anionic surfactant having a specific structure, an ether carboxylate-type anionic surfactant having a specific structure, and an organic carboxylic acid or salt thereof, thereby has a pH of 1 to 5 at 25° C. when diluted 20-fold with water. | 2014-04-03 |
20140094424 | MICROBICIDAL COMPOSITIONS AND METHODS OF PRODUCTION USE THEREOF - Microbicidal compositions that exhibit enhanced microbial efficacy are disclosed, as well as methods of producing and using the microbicidal compositions. | 2014-04-03 |
20140094425 | METHODS FOR TRANSDIFFERENTIATION OF BODY TISSUES - The invention relates to methods for transdifferentiation of body tissues which can be used to generate specific cell types needed for regenerating organs or body parts, following cellular degeneration, injury or amputation. The present invention also describes the use of tissue transdifferentiation for treating cancer and autoimmune diseases. | 2014-04-03 |
20140094426 | AMPHIPHILE PRODRUGS - Amphiphilic prodrugs of general formula A-X are disclosed, wherein A is a biologically active agent or may be metabolized to a biologically active agent; and X is R, or up to three R moieties attached to a linker, Y | 2014-04-03 |
20140094427 | DOSING METHODS FOR TREATING DISEASE - The invention relates to a method for treating disease such as viral infections, tumors, and cancers, comprising administering a TLR7 agonist or TLR7 agonist prodrug according to a cyclical dosing schedule having a dosing period and a resting period. For example, the method encompasses treating disease with: | 2014-04-03 |
20140094428 | DOSAGE REGIMEN FOR SAPACITABINE AND DECITABINE IN COMBINATION FOR TREATING ACUTE MYELOID LEUKEMIA - A first aspect of the invention relates to a method of treating AML in a subject, said method comprising administering to a subject a therapeutically effective amount of (i) sapacitabine, or a metabolite thereof; and (ii) decitabine; in accordance with a dosing regimen comprising at least one first treatment cycle and at least one second treatment cycle, wherein said first treatment cycle comprises administering a therapeutically effective amount of decitabine for 5 to 10 consecutive days followed by a rest period of from 3 to 5 weeks, or until treatment-related toxicities are resolved, whichever is longer; and wherein said second treatment cycle comprises administering a therapeutically effective amount of sapacitabine, or a metabolite thereof, for 3 consecutive days per week, for 2 weeks followed by a rest period of from 2 to 4 weeks, or until treatment-related toxicities are resolved, whichever is longer. | 2014-04-03 |
20140094429 | FGF RECEPTOR-ACTIVATING 3-O-ALKYL OLIGOSACCHARIDES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF - The invention relates to the FGF receptor-activating oligosaccharides corresponding to formula (I): | 2014-04-03 |
20140094430 | HYALURONIC ACID COMPOSITIONS STABILISED AGAINST THE DEGRADING EFFECT OF HEAT OR ENZYMES - The invention relates to the use of an additive to stabilise hyaluronic acid formulated in an aqueous composition against the degrading effect of heat or of enzymes such as hyaluronidase, characterised in that said additive comprises one or more polysaccharides having a molecular weight equal to or greater than 20,000 daltons and solubility in water at least equal to or greater than 1 g/l, the total concentration of said polysaccharide(s) and hyaluronic acid in the composition giving it a viscosity of at least 500 cP, which is particularly suitable for intra-articular, intradermal or intraocular administration to humans or animals. | 2014-04-03 |
20140094431 | METHODS OF MAKING HYDROGELS FOR SOFT TISSUE AUGMENTATION - Hair-like shaped crosslinked hydrogels and methods for preparing such crosslinked hydrogels and are provided. | 2014-04-03 |
20140094432 | METHODS AND SYSTEMS FOR POLYMER PRECIPITATION AND GENERATION OF PARTICLES - Processes for precipitating polymers from a polymer-containing solution are disclosed. | 2014-04-03 |
20140094433 | DERMAL FILLER HYDROGELS WITH VITAMIN A/CYCLODEXTRIN INCLUSION COMPLEXES - Compositions, such as hydrogel compositions, that include a hyaluronic acid, a vitamin A, and a cyclodextrin may be used as medical or cosmetic fillers, implants, or creams. For example, the compositions may be used as dermal fillers. | 2014-04-03 |
20140094434 | AMINO ACID COMPOSITION - Amino acid compositions containing a carbohydrate and any one or more kinds of alanine, proline and glycine as amino acid can suppress a rapid increase in the blood glucose level immediately after ingestion and a decrease in the blood glucose level due to prolonged exercise, and can improve exercise performance. In addition, the present invention provides inhibitors of an increase in the blood glucose level immediately after carbohydrate ingestion, an inhibitor of a decrease in the blood glucose level due to a prolonged exercise, and an exercise performance improver. Therefore, the present invention provides an energy supplement useful for those who exercise (particularly prolonged exercise). | 2014-04-03 |
20140094435 | Use of Dextran Sulfate - A method of inhibiting Instant Blood-Mediated Inflammatory Reaction (IBMIR) in a patient, comprises administering a therapeutically effective amount of dextran sulfate, or a pharmaceutically acceptable salt thereof. A method of inhibiting morphological disruption of a transplanted cell transplant in a patient comprises administering a therapeutically effective amount of dextran sulfate, or a pharmaceutically acceptable salt thereof, to a patient. The dextran sulfate, or said pharmaceutically acceptable salt thereof, has an average molecular weight of less than 20,000 Da and an average sulphur content in a range of 10 to 25%, and the inhibition comprises administering said therapeutically effective amount of said dextran sulfate, or said pharmaceutically acceptable salt thereof, resulting in a concentration of said dextran sulfate, or said pharmaceutically acceptable salt thereof, in the blood of said patient of less than 5 mg/ml. | 2014-04-03 |
20140094436 | IMIDAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. | 2014-04-03 |
20140094437 | HIGH ALCOHOL CONTENT FOAMING COMPOSITIONS - This invention relates to a “high lower alcohol content”(>40% v/v of a C | 2014-04-03 |
20140094438 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PAIN - The claimed invention relates to compositions that may be in a form of a liquid, solid, gel, cream or gel capsule comprising an analgesic, and methods for administering these compositions for treatment of patients suffering from various forms of pain. | 2014-04-03 |
20140094439 | pH DEPENDENT CARRIERS FOR TARGETED RELEASE OF PHARMACEUTICALS ALONG THE GASTROINTESTINAL TRACT, COMPOSITIONS THEREFROM, AND MAKING AND USING SAME - Novel drug carriers capable of targeted and/or pH dependent release of biologically active agents into selected pH environments including the gastrointestinal (GI), ophthalmic, urinary, or reproductive tracts. Unexpectedly, carriers including free fatty acids (FFA) are able to deliver biologically active agents to various pH environments. Such targeted delivery is tailorable and useful for active agents that are: (a) injurious to the upper GI tract (esophagus, stomach, and duodenum), (b) acid labile, (c) impermeable/insoluble compounds in GI fluids, (d) susceptible to first pass metabolism, and/or (e) cause stomach irritation, upset, or dyspepsia. | 2014-04-03 |
20140094440 | NATURAL COMBINATION HORMONE REPLACEMENT FORMULATIONS AND THERAPIES - Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone. | 2014-04-03 |
20140094441 | NATURAL COMBINATION HORMONE REPLACEMENT FORMULATIONS AND THERAPIES - Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone. | 2014-04-03 |
20140094442 | COMBINATIONS COMPRISING ANTI-MUSCARINIC AGENTS AND CORTICOSTEROIDS - Combinations comprising (a) a corticosteroid and (b) an antagonist of M3 muscarinic receptors which is 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane, in the form of a salt having an anion X, which is a pharmaceutically acceptable anion of a mono or polyvalent acid are useful, e.g., for treatment of respiratory disease, e.g., asthma or chronic obstructive pulmonary disease. | 2014-04-03 |
20140094443 | TGR5 Modulators and Methods of Use Thereof - The invention relates to compounds of Formula A: | 2014-04-03 |
20140094444 | COMPOSITIONS AND METHODS FOR TISSUE ENGINEERING AND CELL BASED THERAPIES - The present application discloses strategies to recruit and mobilize stem cells using S1P receptor selective agonists and antagonists as wells as regulators of chemokine receptors. In an in vivo ischemic model, S1P | 2014-04-03 |
20140094445 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS - In one aspect, the invention relates to substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2014-04-03 |
20140094446 | Cyclic Amino Acids for the Treatment of Pain - Compositions comprising cyclic amino acids or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier. Said compositions are for use in the treatment of pain. Pain includes both acute and chronic forms of pain. The preferred cyclic amino acid is 1-aminocyclobutane-1-carboxylic acid (ACBC). | 2014-04-03 |
20140094447 | Pharmaceutical compositions comprising sulbactam and beta-lactamase inhibitor - Pharmaceutical compositions and methods for treating or preventing bacterial infections are disclosed. The pharmaceutical compositions typically comprise pharmaceutically effective amount of: (a) sulbactam or a pharmaceutically acceptable salt thereof, and (b) at least one beta-lactamase inhibitor or a pharmaceutically acceptable salt thereof, with the provision that the beta-lactamase inhibitor is not sulbactam. | 2014-04-03 |