| 13th week of 2012 patent applcation highlights part 50 |
| Patent application number | Title | Published |
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| 20120077926 | METHOD FOR PRODUCING FLUORORUBBER COMPOSITION - The present invention provides a method for producing a fluororubber composition that has excellent heat resistance and excellent mechanical properties at high temperatures. The production method comprises the step of mixing a fluororubber (A) and a carbon black (B) in the presence of an organic amine compound (C1) and/or an acid acceptor (C2) to prepare a mixed product, wherein the mixed product has a highest temperature Tm of 80° C. to 220° C. while being mixed and has a highest temperature of 80° C. to 220° C. upon being discharged. | 2012-03-29 |
| 20120077927 | FLUORORUBBER COMPOSITION - The present invention provides a fluororubber composition that has excellent heat resistance and excellent mechanical properties at high temperatures. The fluororubber composition comprises 100 parts by mass of a peroxide cross-linkable fluororubber (A); 5 to 50 parts by mass of a carbon black (B); 0.1 to 10 parts by mass of a peroxide cross-linking agent (C); and 10 parts by mass or smaller of a bisolefin (D). | 2012-03-29 |
| 20120077928 | Polymerization using a diallylamine and a compound comprising a macromolecular chain comprising units derived from this amine - Compounds containing macromolecular chains and having a structured architecture are prepared by polymerization of macromolecular monomers containing diallylamine structural units. | 2012-03-29 |
| 20120077929 | POLYTRIMETHYLENE ETHER-BASED POLYURETHANE IONOMERS - Disclosed is aqueous polyurethane dispersion with a polyurethane having a polymeric backbone with ionic and/or ionizable functionality incorporated into the polymeric backbone. The polymeric backbone consists essentially of one or more non-ionic segments derived from a reaction product of polytrimethylene ether glycol and a diisocyanate. The manufacture of such polyurethanes is also disclosed. | 2012-03-29 |
| 20120077930 | MOLD-RELEASING AGENT - Disclosed is a mold-releasing agent comprising, as active ingredients, a graft copolymer (A) in which a polyalkylene glycol or an alkyl ether thereof is graft-copolymerized with a polyfluoro-1-alkene represented by the general formula: C | 2012-03-29 |
| 20120077931 | AQUEOUS POLYMERIZATION OF FLUORINATED MONOMER USING POLYMERIZATION AGENT COMPRISING FLUOROPOLYETHER ACID OR SALT AND SHORT CHAIN FLUOROSURFACTANT - A process comprising polymerizing at least one fluorinated monomer in an aqueous medium containing initiator and polymerization agent to form an aqueous dispersion of particles of fluoropolymer, the polymerization agent comprising:
| 2012-03-29 |
| 20120077932 | COMPOSITIONS BASED ON DIISOCYANATES OBTAINED FROM RENEWABLE RAW MATERIALS - The invention relates to compositions based on 2,5-diisocyanato-1,4:3,6-dianhydro-2,5-dideoxy-D-manitol (I), 2,5-diisocyanato-1,4:3,6-dianhydro-2,5-dideoxy-D-glucitol (II), and/or 2,5-diisocyanato-1,4:3,6-dianhydro-2,5-dideoxy-L-iditol (III), alone or in any mixtures. | 2012-03-29 |
| 20120077933 | Polysiloxane Modified Titanium Dioxide - A particle of titanium dioxide treated with a polysiloxane is disclosed. One or more silicon atoms of the polysiloxane is substituted with an alkylene group terminating with a silyl group containing three substituents selected from the group consisting of hydroxy, halo, alkoxy, acetoxy, and mixtures thereof. These treated particles are blended with organic polymers to form a polyethylene polymer matrix having dispersed therein at least 55 wt % polysiloxane modified titanium dioxide particles. | 2012-03-29 |
| 20120077934 | Functional Polyisobutylene Based Macromonomers And Methods For Making And Using The Same - A method of synthesizing a functionalized polymer represented by the structural formula (I) comprising a step of reacting a polymer represented by structural formula (II) with a compound Nu | 2012-03-29 |
| 20120077935 | FLUORINE-CONTAINING ELASTOMER COMPOSITIONS SUITABLE FOR HIGH TEMPERATURE APPLICATIONS - A curable fluorine-containing elastomer composition is described which includes a first curable perfluoropolymer comprising tetrafluoroethylene, a first perfluoroalkylvinyl ether and at least one first cure site monomer having at least one cure site, wherein tetrafluoroethylene is present in the first curable perfluoropolymer in an amount of at least about 50 mole percent; a second curable perfluoropolymer comprising tetrafluoroethylene, a second perfluoroalkylvinyl ether and at least one second cure site monomer having at least one cure site, wherein the second curable perfluoropolymer comprises fluoroplastic particles therein; and at least one curative. Cured compositions and molded articles formed from such compositions are also disclosed. | 2012-03-29 |
| 20120077936 | COVALENTLY FUNCTIONALIZED PARTICLES FOR SYNTHESIS OF NEW COMPOSITE MATERIALS - The present invention includes compositions and methods for synthesis of composite materials involving gas phase plasma polymerization to covalently plasma graft an organic molecule onto particles; covalently binding an organic monomer to the functionalized particles; and, polymerizing the organic monomers into hybrid polymer composite materials. | 2012-03-29 |
| 20120077937 | Method For Preparing A Suspension Of PVC Grafted Onto An Elastomer - The invention pertains to the field of PVC production. More particularly, the invention relates to a method for preparing a polymer including vinyl chloride monomers that are polymerized and grafted onto acrylic, styrene, and/or ethylene monomers polymerized in the form of an elastomer. | 2012-03-29 |
| 20120077938 | VIBRATION ISOLATION RUBBER - The present invention provides a vibration isolation rubber excellent not only in heat-aging resistance and oil resistance but also in mechanical properties at high temperatures. The vibration isolation rubber of the present invention comprises a cross-linked fluororubber layer obtainable by cross-linking a fluororubber composition containing a fluororubber (A) and a carbon black (B). The cross-linked fluororubber layer has a loss modulus E″ of 400 kPa or higher and 6,000 kPa or lower determined by a dynamic viscoelasticity test (measurement temperature: 160° C., tensile strain: 1%, initial force: 157 cN, and frequency: 10 Hz). | 2012-03-29 |
| 20120077939 | FLUORORUBBER MOLDED ARTICLE - The present invention provides a fluororubber formed product having excellent heat resistance and excellent mechanical properties at high temperatures. The formed product comprises a cross-linked fluororubber product obtainable by cross-linking a fluororubber composition containing a fluororubber (A) and a carbon black (B), the fluororubber (A) being a vinylidene fluoride fluororubber including 48 to 88 mol % of a structural unit derived from vinylidene fluoride and 0 to 10 mol % of a structural unit derived from tetrafluoroethylene relative to the total amount 100 mol % of structural units derived from all monomer components, the cross-linked fluororubber product having a loss modulus E″ of 400 kPa or higher and 6,000 kPa or lower determined by a dynamic viscoelasticity test (measurement temperature: 160° C., tensile strain: 1%, initial force: 157 cN, and frequency: 10 Hz). | 2012-03-29 |
| 20120077940 | Method For Preparing A Superplasticizer - The invention chiefly concerns a method for preparing polyalkoxylated polycarboxylates in which the following are caused to react in the presence of water and a catalyst at a temperature of between 120 and 250° C.:
| 2012-03-29 |
| 20120077941 | POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS - A method for preparing a functionalized polymer, the method comprising the steps of (i) polymerizing conjugated diene monomer by employing a lanthanide-based catalyst to form a reactive polymer, and (ii) reacting the reactive polymer with a protected oxime compound. | 2012-03-29 |
| 20120077942 | Materials Comprising a Matrix and Process for Preparing Them - The present invention is concerned with a material comprising: a matrix material comprising a plurality of urethane and/or urea and/or isocyanurate groups and having a hardblock content of more than 75% (hereinafter called matrix A); and a polymeric material which 1) has no groups which are able to form a urethane, urea or isocyanurate group with an isocyanate group, 2) exhibits a phase change as measured by differential scanning calorimetry (DSC) in the temperature range −10° C. to +60° C. with an enthalpy ΔHm of at least 87 kJ/kg, 3) is interpenetrating said matrix A, and 4) has an average molecular weight of more than 700 and comprises at least 50% by weight of oxyalkylene groups, based on the weight of this material, wherein at least 85% of the oxyalkylene groups are oxyethylene groups (hereinafter called polymeric material B); and wherein the relative amount of said matrix A and of said polymeric material B, on a weight basis, ranges from 15:85 to 75:25. Process for preparing such material. | 2012-03-29 |
| 20120077943 | Low Temperature Curable Epoxy Compositions - A heat curable epoxy composition comprising the contact product of an epoxy resin, an epoxy curing agent and an accelerator for the epoxy curing agent, the curing agent or the accelerator comprising the reaction product of (a) a phenolic resin (a) of general formula: | 2012-03-29 |
| 20120077944 | Catalyst Components for the Polymerization of Olefins and Catalysts Therefrom Obtained - Catalyst components for the polymerization of olefins CH | 2012-03-29 |
| 20120077945 | Novel Class Of Olefin Metathesis Catalysts, Methods Of Preparation, And Processes For The Use Thereof - This invention relates to a metathesis catalyst comprising (i) a Group 8 metal hydride-dihydrogen complex represented by the formula: | 2012-03-29 |
| 20120077946 | CATIONICALLY POLYMERIZABLE RESIN COMPOSITION AND CURED OBJECT OBTAINED THEREFROM - Disclosed is a cationically polymerizable resin composition which includes an oxetane-ring-containing vinyl ether compound (A) and/or an alicyclic-epoxy-containing vinyl ether compound (B); and an oligomer or polymer (C) having a molecular weight of 500 or more, being liquid at 0° C., and containing at least one of structures represented by following Formulae (1a) to (1f), wherein R | 2012-03-29 |
| 20120077947 | METHOD FOR PRODUCING (METH) ACRYLIC ACID - The objective of the present invention is to provide a method for efficiently producing (meth)acrylic acid by crystallization using a plurality of crystallizer to purify (meth)acrylic acid and a refrigerator for supplying both of a cooling medium and a heating medium, while the refrigerator is stably operated for supplying media having a proper temperature and the temperature of the crystallizers is maintained. The method for producing (meth)acrylic acid according to the present invention is characterized in comprising the steps of at least crystallizing (meth)acrylic acid and melting the (meth)acrylic acid crystal obtained in the crystallization step; wherein two or more crystallizers are employed; when both of the crystallization step and the melting step are concurrently carried out in separate crystallizers, from a refrigerator, a cooling medium is supplied to a crystallizer for carrying out the crystallization step to crystallize (meth)acrylic acid and a heating medium is supplied to other crystallizer for carrying out the melting step to melt the (meth)acrylic acid crystal; and when only the crystallization step is carried out before the melting step is carried out, a temperature of a heating medium to be returned to the refrigerator is previously decreased to be lower than a set temperature for the melting step before only the crystallization step is carried out. | 2012-03-29 |
| 20120077948 | Methods - The invention relates to a method of making a polypeptide comprising an orthogonal functional group, said orthogonal functional group being comprised by an aliphatic amino acid or amino acid derivative, said method comprising providing a host cell; providing a nucleic acid encoding the polypeptide of interest; providing a tRNA-tRNA synthetase pair orthogonal to said host cell; adding an amino acid or amino acid derivative comprising the orthogonal functional group of interest, wherein said amino acid or amino acid derivative is a substrate for said orthogonal tRNA synthetase, wherein said amino acid or amino acid derivative has an aliphatic carbon backbone; and incubating to allow incorporation of said amino acid or amino acid derivative into the polypeptide of interest via the orthogonal tRNA-tRNA synthetase pair. The invention also relates to certain amino acids, and to polypeptides comprising same. | 2012-03-29 |
| 20120077949 | Organic semiconductor copolymers containing oligothiophene and n-type heteroaromatic units - An exemplary organic semiconductor copolymer includes a polymeric repeat structure having a polythiophene structure and an electron accepting unit. The electron accepting unit has at least one electron-accepting heteroaromatic structure with at least one electron-withdrawing imine nitrogen in the heteroaromatic structure or a thiophene-arylene comprising a C | 2012-03-29 |
| 20120077950 | Compound Suitable as Polymeric Dispersant - A compound according to the present invention is obtainable by reacting a polyisocyanate with a monoalkylether of a polyoxyalkylenemonoamine, in such an amount that substantially no free isocyanate groups are present in the component. The polyisocyanate itself is an adduct of two polyisocyanate molecules with one isocyanate reactive molecule chosen from the group consisting of a polyoxyalkylene diamine, a polyoxyalkylene diol, a polyoxyalkylenealkanolamine, a polyester diamine, a polyester diol and a polyesteralkanolamine, the average molecular weight of the isocyanate reactive molecule being more than 1000. | 2012-03-29 |
| 20120077951 | METHOD FOR INCREASING THE MOLECULAR WEIGHT OF A POLYESTER GRANULATE BY USING ITS RESIDUAL HEAT - The present invention relates to increasing the molecular weight during a thermal treatment of polyester in combination with a latent heat granulation. With the newly-developed method, an SSP (Solid State Postcondensation) can be directly combined with an underwater granulation. The method differs from a conventional solid state postcondensation by an increase in the molecular weight being possible without additional heat input and hence only by using the residual heat and the crystallisation heat present. A characterising element is improved water separation and dehumidification during the granulation. Only in this way is an increase in viscosity possible even with a small granulate of an average particle weight less than 20 mg. | 2012-03-29 |
| 20120077952 | PROCESS FOR THE PREPARATION OF COPOLYMER - 1 (COP-1), COMPOSED OF L-ALANINE, L-LYSINE, L-GLUTAMIC ACID AND L-TYROSINE-DRUG FOR THE TREATMENT OF MULTIPLE SCLEROSIS - A process for the synthesis of copolymer-1 composed of L-alanine, LHysine, L-glutamic acid and L-tyrosine for the treatment of multiple sclerosis. The molecular weight of copolymer-1 is between 8-19 KDa. Process is initiated by supported dialkyl amine. The copolymer-1 of the invention has acid content of less than 1%. | 2012-03-29 |
| 20120077953 | SYNTHESIS OF TRI-COMPONENT RESINS - A resinous compound of the formulas | 2012-03-29 |
| 20120077954 | PROCESS FOR REDUCING MOISTURE IN A BIODEGRADABLE IMPLANT DEVICE - The disclosed process comprises freeze-drying a biodegradable implant device comprised or one or more polyesters to thereby reduce moisture content in the device. | 2012-03-29 |
| 20120077955 | HOLE TRANSPORT POLYMERS - There is provided a polymer made from a monomer having Formula I: | 2012-03-29 |
| 20120077956 | Method of Producing Polymeric Phenazonium Compounds - A process of making a polymeric phenazonium compound having the general formula: | 2012-03-29 |
| 20120077957 | Lactam-Bridged Melanocortin Receptor-Specific Peptides - Lactam-bridged melanocortin receptor-specific cyclic peptides of the formula | 2012-03-29 |
| 20120077958 | Multimodal Imaging of Fibrin - Fibrin-specific imaging agents that contain at least two imaging reporters are described, as well as methods of making and using the contrast agents. | 2012-03-29 |
| 20120077959 | Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate - Cobalt(II) complexes of the D | 2012-03-29 |
| 20120077960 | FLUOROBODIES: INTRINSICALLY FLUORESCENT BINDING LIGANDS - Binding ligands with intrinsic fluorescence (“fluorobodies”), fluorobody libraries, and methods of preparing fluorobodies are provided. In one aspect, the invention provides fluorobodies generated from a highly stable, artificial fluorescent protein, eCGP123 and derivatives thereof. | 2012-03-29 |
| 20120077961 | ENHANCED PURIFICATION OF ANTIBODIES AND ANTIBODY FRAGMENTS BY APATITE CHROMATOGRAPHY - Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one intact non-aggregated antibody, or at least one immunoreactive antibody fragment, from an impure preparation. Integration of such methods into multi-step procedures with other fractionation methods are additionally disclosed. | 2012-03-29 |
| 20120077962 | HUMANIZED ANTI-PROSTATE STEM CELL ANTIGEN MONOCLONAL ANTIBODY - Prostate stem cell antigen (PSCA) is expressed in the majority of prostate cancer patients, making it an ideal target for cancer immunotherapy. Murine monoclonal antibody 1G8 binds to PSCA with nanomolar affinity, but its efficacy as a therapeutic agent is limited by the generation of a HAMA response. The present invention discloses humanized 1G8 antibodies in which the majority of the mouse-derived epitopes have been removed. These humanized antibodies bind PSCA with high affinity and specificity, and have been shown to reduce human bladder tumor take in a nude mouse model. These characteristics make the humanized antibodies of the present invention attractive agents for the treatment and detection of tumors expressing PSCA. | 2012-03-29 |
| 20120077963 | METHOD FOR REMOVING VIRUSES FROM HIGH CONCENTRATION MONOCLONAL ANTIBODY SOLUTION - An object of the present invention is to provide a method for removing even small viruses from a high concentration monoclonal antibody solution using a membrane, and thus for recovering the antibody within a short time at high yield in the form of a filtrate. The present invention provides a method for producing a preparation containing a monoclonal antibody, which comprises a step of removing viruses by filtering viruses in a monoclonal antibody solution using a virus-removing membrane, wherein
| 2012-03-29 |
| 20120077964 | ANTAGONISTS OF PCSK9 - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 2012-03-29 |
| 20120077965 | NON-AQUEOUS SYNTHESIS OF POLYSACCHARIDE-PROTEIN CONJUGATES FOR VACCINES - The invention is a novel chemical coupling methodology for the synthesis of a stable polysaccharide-protein conjugates as the immunogenic component for vaccines. A covalent bond is formed between polysaccharide and protein in the dry state in the absence of water and oxygen. A polysaccharide antigen is covalently linked to the protein by activating the polysaccharide with periodate to introduce aldehyde groups into the polysaccharide, lyophilizing an aqueous mixture of a protein and activated polysaccharide, sealing the dry lyophilized mixture in a vessel under vacuum or inert gas and then incubating the sealed vessel at an elevated temperature. | 2012-03-29 |
| 20120077966 | POLYNUCLEOTIDE AND POLYPEPTIDE SEQUENCE AND METHODS THEREOF - The present disclosure relates to a field of recombinant DNA therapeutics. It involves the bio-informatics design, synthesis of artificial gene for human insulin precursor including leader peptide coding sequence, cloning in an expression vector and expression in an organism, preferably | 2012-03-29 |
| 20120077967 | NOVEL TECHNETIUM AND RHENIUM COMPLEXES - Novel radioactive technetium and rhenium complexes comprising tripodal ligands are provided by the present invention. In particular, Tc(I) complexes are provided by the present invention. Novel ligands suitable for the formation of the technetium and rhenium complexes of the invention are also provided, as well as radiopharmaceutical compositions comprising said complexes, kits for their preparation. The invention also relates to the use of | 2012-03-29 |
| 20120077968 | NUCLEIC ACID SEQUENCES ENCODING AN1-LIKE ZINC FINGER PROTEINS - Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants. | 2012-03-29 |
| 20120077969 | NUCLEIC ACID PURIFICATION METHOD - The present invention relates to a method for purifying a defined amount of nucleic acids from a nucleic acid-containing sample, which has at least the following steps: (a.) contacting the nucleic acid-containing sample with a defined amount of a nucleic acid binding phase with the following features: (i) the nucleic acid binding phase has nucleic acid binding ligands that have at least one protonatable group; (ii) the nucleic acid binding ligands are bound to a carrier; (iii) the nucleic acid binding phase has a surface with a low charge density, wherein the amount of nucleic acids in the sample exceeds the binding capacity of the amount of nucleic acid binding phase used; (b.) binding of the nucleic acids to the nucleic acid binding phase at a pH (binding pH) that is below the pKs value of at least one of the protonatable groups; (c.) elution of the nucleic acids at a pH that is above the binding pH, wherein a defined amount of nucleic acids is obtained. Furthermore, corresponding kits and nucleic acid binding phases, which can be used for the purification of nucleic acids, are disclosed. | 2012-03-29 |
| 20120077970 | METHOD FOR PREPARING MOLECULAR COMPLEXES BETWEEN ADAPALENE AND CYCLODEXTRINS - A method for preparing molecular complexes between Adapalene and cyclodextrins using the technology of dense fluids under pressure, especially that of CO2 is described. | 2012-03-29 |
| 20120077971 | Optimization of Nucleation and Crystallization for Lyophilization Using Gap Freezing - This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously. The as frozen solution then provides a lyophilized cake of the solutes with large and uniform pores. | 2012-03-29 |
| 20120077972 | Chlorination of sucrose-6-esters - A method for the chlorination of a sucrose-6-acylate to produce a 4,1′,6′-trichloro-4,1′,6′-trideoxy-galactosucrose-β-acylate wherein said method comprises: (i) reacting the sucrose-6-acylate with a chlorinating agent in a reaction vehicle comprising a tertiary amide in order to chlorinate the 4, V and 6′ positions of the sucrose-6-acylate; and (ii) quenching the product stream of (i) to produce a 4,1′,6′-trichloro-4,1′,6′-trideoxy-galactosucrose-6-acylate; wherein before said quenching, a portion of the tertiary amide is removed. | 2012-03-29 |
| 20120077973 | Sulphonylated Diphenylethylenediamines, Method for Their Preparation and Use in Transfer Hydrogenation Catalysis - A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X | 2012-03-29 |
| 20120077974 | REDOX DRUG DERIVATIVES - The present invention provides redox drug derivatives. In particular, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, (3R,4R,5S)-4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester, (3S)-3-(aminomethyl)-5-methylhexanoic acid, (3S)-1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-α-α-diphenyl-3-pyrrolidineacetamide, (1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethyl-butyl]-4-(diaminomethylideneamino)-2-hydroxy-cyclopentane-1-carboxylic acid and (2R,3R,4S)-4-[(diaminomethylidene)amino]-3-acetamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid redox derivatives. | 2012-03-29 |
| 20120077975 | HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHOD OF USE - The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to compositions comprising said human protein tyrosine phosphatase beta (HPTP-β) inhibitors, and to methods for regulating angiogenesis. | 2012-03-29 |
| 20120077976 | CAMPHOR-DERIVED COMPOUNDS, METHOD FOR MANUFACTURING THE SAME, AND APPLICATION THEREOF - Camphor-derived compounds are disclosed, which are represented as the following formula (I): | 2012-03-29 |
| 20120077977 | PROCESS FOR PREPARING (METH)ACRYLIC ESTERS OF N,N-SUBSTITUTED AMINO ALCOHOLS - The present invention relates to a process for preparing (meth)acrylic esters (F) of N,N-substituted amino alcohols, by transesterifying N,N-substituted amino alcohols (I) | 2012-03-29 |
| 20120077978 | Structure Based Design Of Inhibitors Of Human Thymidylate Synthase - A compound is provided having the chemical structure: | 2012-03-29 |
| 20120077979 | 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors - Compounds of the formula | 2012-03-29 |
| 20120077980 | METHOD FOR PRODUCING A SOLID PREPARATION - A method for producing a solid preparation containing a compound represented by the formula (I) below or a pharmacologically acceptable salt thereof, which includes a step wherein a composition containing the compound represented by the formula (I) below or a pharmacologically acceptable salt thereof is mixed, while applying a mechanical stress to the composition. The compound of the formula (I) is as follows: | 2012-03-29 |
| 20120077981 | N[S(4-ARYL-TRIAZOL-3-YL)ALPHA-MERCAPTOACETYL]-P-AMINO BENZOIC ACIDS AS HIV REVERSE TRANSCRIPTASE INHIBITORS - A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. | 2012-03-29 |
| 20120077982 | Methods for Synthesizing 3-(Substituted Dihydroisoindolinone-2-YL)-2, 6-Dioxopiperidine, and Intermediates Thereof - The present invention discloses methods for synthesizing 3-(substituted dihydroisoindolinone-2-yl)-2,6-dioxopiperidine and intermediates thereof, namely, the synthesis of compounds of the Formula (I), with each substitutional group defined in the patent specification. Owing to the advantages of high productivity, little influence to the environment and material accessibility, the methods of the present invention is suitable for industrial production. | 2012-03-29 |
| 20120077983 | LEAD-FREE PRIMARY EXPLOSIVE COMPOSITION - Embodiments of the present subject matter provide a compound and material that may be used as a lead-free primary explosive. An embodiment of the present subject matter provides the compound copper(I) nitrotetrazolate. Certain embodiments of the present subject matter provide methods for preparing lead-free primary explosives. The method includes: providing cuprous salt; providing water; providing 5-nitrotetrazolate salt; combining the cuprous salt, water and 5-nitrotetrazolate salt to form a mixture; and heating the mixture. The method may also include providing cuprous chloride and providing sodium 5-nitrotetrazolate. Certain embodiments of the present subject matter also provide methods for preparing copper(I) nitrotetrazolate. The method includes: providing cuprous salt; providing water; providing 5-nitrotetrazolate salt; combining the cuprous salt, water and 5-nitrotetrazolate salt to form a mixture; and heating the mixture. The method may also include providing cuprous chloride and providing sodium 5-nitrotetrazolate. | 2012-03-29 |
| 20120077984 | Process For Preparing Epothilone Derivatives By Selective Catalytic Epoxidation - The present invention describes a novel process for preparing an epothilone derivative using substituted pyridines and methyltrioxorhenium as catalyst. | 2012-03-29 |
| 20120077985 | PROCESS FOR PRODUCING FUSED IMIDAZOLE COMPOUND, REFORMATSKY REAGENT IN STABLE FORM, AND PROCESS FOR PRODUCING THE SAME - The present invention provides an industrially advantageous process for producing a steroid C | 2012-03-29 |
| 20120077986 | NOVEL PREPARATION OF ANTICANCER-ACTIVE TRICYCLIC COMPOUNDS VIA ALKYNE COUPLING REACTION - The present invention is directed to provide a novel preparation of anticancer-active tricyclic compounds via alkyne coupling reaction. The present invention provides a process for preparing a compound of formula (Ia) or (Ib): | 2012-03-29 |
| 20120077987 | ORGANIC COMPOUND, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE - A novel substance with which an increase in life and emission efficiency of a light-emitting element can be achieved is provided. A carbazole compound having a structure represented by General Formula (G1) is provided. Note that a substituent which makes the HOMO level and the LUMO level of a compound in which a bond of the substituent is substituted with hydrogen deep and shallow, respectively is used as each of substituents in General Formula (G1) (R | 2012-03-29 |
| 20120077988 | BRANCHED HETERO POLYETHYLENE GLYCOL AND INTERMEDIATE - A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]: | 2012-03-29 |
| 20120077989 | CYCLIC IMIDATE LIGANDS - The present invention relates to a use of a cyclic imidate as a ligand for catalysis in which the ligand contains sub-structure (Y) as a minimal structural motive, wherein the carbon atoms and the nitrogen atom can be optionally substituted by a chemical substituent. | 2012-03-29 |
| 20120077990 | Alkene Aziridination - A process for the asymmetric aziridination of an alkene comprising treating the alkene with a sulfonyl azide, preferably trichloroethoxysulfonyl azide, in the presence of a cobalt(II) porphyrin. | 2012-03-29 |
| 20120077991 | NOVEL INSECTICIDES - Compounds of formula | 2012-03-29 |
| 20120077992 | DEVICE FOR CARRYING OUT CHEMICAL REACTIONS UNDER HOMOGENOUS AND HETEROGENOUS CONDITIONS - The present invention relates to a device for treatment of material transported through the device comprising at least one porous element consisting of solid, for example metallic, structure which allows cross-flow of the material through the porous element. The invention also relates to various types of uses of the device. A device in accordance with the invention is particularly useful to carry out chemical reactions under homogenous and heterogeneous conditions. Such a device hereinafter also referred as reactor may comprises a tube ( | 2012-03-29 |
| 20120077993 | SPIRO EPOXIDES AS INTERMEDIATES - The present invention provides compounds of formula (I) wherein the substituents are as defined in claim | 2012-03-29 |
| 20120077994 | METHOD OF OBTAINING SECONDARY PLANT CONSTITUENTS - The present invention relates to a method of isolating phenolic secondary plant constituents from plant material using a microporous membrane which displays affinity ligands for the phenolic secondary plant constituents. | 2012-03-29 |
| 20120077995 | PROCESS FOR THE PRODUCTION OF DRONEDARONE INTERMEDIATES - A process for the production of Dronedarone intermediates of the formula (I), by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-(4-methoxyphenyl)-ethanone, subsequent treatment of the ester with bases and a zeolite (alumosilicate) catalyst and optional subsequent demethylation. This process can be used for the production of Dronedarone. | 2012-03-29 |
| 20120077996 | Purification of propylene oxide - The invention is a method of purifying propylene oxide containing acetone, water, methanol, methyl formate, aldehydes, and hydrocarbons impurities. The method comprises contacting the propylene oxide with a glycol and a C | 2012-03-29 |
| 20120077997 | EO PROCESS CONTROL - A process for the production of an olefin oxide, which process comprises reacting a feed comprising an olefin and oxygen in a reactor tube in the presence of a silver-containing catalyst, wherein the presence of water in the catalyst bed is controlled such that the ratio of the partial pressure of water (PPH | 2012-03-29 |
| 20120077998 | USE OF STRUCTURED CATALYST BEDS FOR PREPARING ETHYLENE OXIDE - The present invention relates to a process for preparing ethylene oxide by reaction of ethylene with oxygen in the presence of at least one silver-comprising catalyst, wherein the reaction takes place in a reactor which has a catalyst packed bed having at least two zones (i) and (ii) and the silver content of the catalyst in zone (i) is lower than the silver content of the catalyst in zone (ii). The catalyst packed bed preferably has a further zone (a) with which the reaction mixture comes into contact before the zones (i) and (ii). According to the invention, the silver content of the catalyst in the zone (a) is higher than the silver content of the catalyst in zone (i). | 2012-03-29 |
| 20120077999 | Method For Obtaining A Fraction Enriched With Functionalized Fatty Acid Esters From Seeds of Oleaginous Plants - The invention relates to a method for the selective extraction of functionalised fatty acid esters from seeds of oleaginous plants, wherein said method includes: a) at least one step of extracting fatty acid esters that comprises simultaneously feeding into a reactor containing said seeds a light anhydrous alcohol, a basic catalyst and an extraction solvent non-miscible with said light alcohol and in which said functionalised fatty ester is not soluble in order to obtain a mixture of esters and glycerol; b) and at least one step of selectively extracting hydroxylated fatty acid esters by feeding into the reactor said extraction solvent in a backflush direction relative to the light alcohol in order to obtain an alcohol phase enriched with fatty acid esters, a glycerol phase and a cake. The invention can be used for obtaining a fraction having a high concentration of hydroxylated or epoxydised functionalised fatty acid esters, and a solvent phase containing the other non-functionalised fatty acid esters directly from the seeds of oleaginous plants. | 2012-03-29 |
| 20120078000 | ALKYLENE OXIDE-ADDUCTED HYDROCARBYL AMIDES - A process is described for preparing alkylene oxide-adducted hydrocarbyl amides having less than 2 wt % of amine by-products by
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| 20120078001 | Process for Preparing ALkoxylation Catalyst and Alkoxylation Process - A process for preparing an alkoxylation catalyst wherein a catalyst precursor which is formed from an alkoxylated alcohol and an alkaline earth metal compound to form a dispersion of an alkaline earth metal species is reacted with propylene oxide to propoxylate at least a portion of the ethoxylated alcohol. | 2012-03-29 |
| 20120078002 | Recording Sheet for Ink Jet Printing - A method for the preparation of silicon dioxide dispersions is described, wherein the surface of the silicon dioxide is modified by a treatment with the reaction products of a compound of trivalent aluminum with least one aminoorganosilane. These reaction products are formed in a separate reaction step. The present invention also relates to recording sheets for ink jet printing having such a dispersion incorporated in an ink-receiving layer. | 2012-03-29 |
| 20120078003 | Use of pressure swing absorption for water removal from a wet methanol stream - The present invention includes a process to dry a feed steam containing alcohol and a small quantity of water. The process includes the step of using pressure swing adsorption to produce a first alcohol stream of substantially dehydrated alcohol and a second mixed stream of water and alcohol. The second mixed stream is distilled in a distillation column to produce a relatively purified water stream and a wet alcohol stream. The wet alcohol stream is added to the feed stream. Optionally the present invention is used to recover excess methanol from a biodiesel reactor that uses one or both of the transesterification reaction and the esterification reaction. The biodiesel reactor produces a product stream comprising fatty acid esters, water and alcohol. Water and alcohol is separated from the product stream. The alcohol is dried as noted above. Dried alcohol is recycled to one or both of the transesterification reaction and the esterification reaction. | 2012-03-29 |
| 20120078004 | Acrylic Acid from Lactide and Process - Technical grade acrylic acid derived from renewable resources utilizing a homogeneous nickel catalyst system by a process including reacting lactide with acetic acid to form 2-acetoxypropionic acid in the presence of a homogeneous nickel catalyst, pyrolyzing, with or without a catalyst, the 2-acetoxypropionic acid to acrylic acid and acetic acid, condensing and collecting the pyrolysis products in the presence of polymerization inhibitor(s) and purfying the acrylic acid by distillation in the presence of polymerization inhibitor(s). Acrylic acid and methyl acrylate are produced from methyl 2-acetoxypropionate which comes from fermentation derived lactic acid. The disclosed process will produce a “green” (i.e. renewable resources derived) acrylic acid and methyl acrylate ester. | 2012-03-29 |
| 20120078005 | CARBONYLATION PROCESS - A process for the production of acetic acid and/or methyl acetate by the carbonylation of methanol, methyl acetate and/or dimethyl ether with carbon monoxide in the presence of a desilicated mordenite catalyst. | 2012-03-29 |
| 20120078006 | Integrated Process for the Production of Vinyl Acetate from Acetic Acid Via Ethylene - This invention provides an integrated two stage economical process for the production of vinyl acetate monomer (VAM) from acetic acid in the vapor phase. First, acetic acid is selectively hydrogenated over a hydrogenating catalyst composition to form ethylene either in a single reactor zone or in a dual rector zone wherein the intermediate hydrogenated products are either dehydrated and/or cracked to form ethylene. In a subsequent second stage so formed ethylene is reacted with molecular oxygen and acetic acid over a suitable catalyst to form VAM. In an embodiment of this invention reaction of acetic acid and hydrogen over a hydrogenation catalyst and subsequent reaction over a dehydration catalyst selectively produces ethylene, which is further mixed with acetic acid and molecular oxygen and reacted over a supported palladium/gold/potassium catalyst. | 2012-03-29 |
| 20120078007 | PROCESS FOR PREPARATION OF ISOSULFAN BLUE - A process for the preparation of isosulfan blue (Active Pharmaceutical Ingredient) is provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2,5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon mild oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater. | 2012-03-29 |
| 20120078008 | Process for Reducing Inorganics from and Concentrating Anionic Surfactant Solutions - A process including contacting one or more Strecker sulfonation reaction products of one or more halogenated alkyl ethers in the presence of sulfite with one or more polar water soluble organic solvents selected from acetone, methyl ethyl ketone, the C | 2012-03-29 |
| 20120078009 | PROCESS FOR THE PREPARATION OF CILASTATIN AND SODIUM SALT - An improved process for preparing Cilastatin Sodium including dissolving Cilastatin acid in a solvent using an organic base, adding sodium salt of a week acid and isolating Cilastatin Sodium. | 2012-03-29 |
| 20120078010 | PROCESS FOR RECOVERING AND RECYCLING AN ACID CATALYST - Disclosed is a process for the extractive recovery of an acid catalyst from an aqueous mixture of glycolic acid with an extraction solvent comprising a tertiary amine or an onium carboxylate compound, a modifier, and a diluent. The acid catalyst, which can comprise strong acids such as sulfuric acid, alkyl sulfonic acids, and fluoroalkyl sulfonic acids, can be recovered by back extraction with aqueous formaldehyde and recycled to a process for the preparation of glycolic acid by the acid-catalyzed carbonylation of formaldehyde. | 2012-03-29 |
| 20120078011 | PUMP AROUND REACTOR FOR PRODUCTION OF ACETIC ACID - The present invention relates to improved processes for the manufacture of acetic acid. A pump around reactor is used to produce additional heat for the production of steam. The pump around reactor receives a portion of the reaction solution produced by the carbonylation reactor and further reacts that portion with additional carbon monoxide and/or reactants. | 2012-03-29 |
| 20120078012 | PRODUCTION OF ACETIC ACID WITH HIGH CONVERSION RATE - A process for producing acetic acid comprising the steps of reacting carbon monoxide and at least one of methanol and a methanol derivative in a first reactor under conditions effective to produce a crude acetic acid product; separating the crude acetic acid product into at least one derivative stream, at least one of the at least one derivative stream comprising residual carbon monoxide; and reacting at least a portion of the residual carbon monoxide with at least one of methanol and a methanol derivative over a metal catalyst in a second reactor to produce additional acetic acid. | 2012-03-29 |
| 20120078013 | METHOD FOR PRODUCING 4-SUBSTITUTED BENZOTHIOAMIDE DERIVATIVE - Disclosed is a method appropriate for safely, economically and easily producing at a high yield a 4-substituted benzothioamide derivative which is useful as an intermediate in the production of a 2-(3-cyanophenyl)thiazole derivative useful as a drug for gout. Specifically disclosed is a method for producing a 4-substituted benzothioamide derivative represented by formula (A). | 2012-03-29 |
| 20120078014 | METHOD FOR MANUFACTURING CYCLOHEXANONE OXIME - To produce cyclohexanone oxime stably for a long time by an ammoximation reaction of cyclohexanone. Cyclohexanone oxime is produced by performing an ammoximation reaction of cyclohexanone with hydrogen peroxide and ammonia in the presence of titanosilicate and a solid containing a silicon compound, wherein the solid containing a silicon compound is one that had been used in a Beckmann rearrangement reaction of cyclohexanone oxime as a catalyst. | 2012-03-29 |
| 20120078015 | Chemical Installation - According to the present invention, a chemical installation is provided. The chemical installation comprises A first unit for providing a first aqueous waste stream comprising nitrobenzene; At least a second unit for providing a second aqueous waste stream comprising aniline. The chemical installation comprises an aniline cleaning apparatus for removing nitrobenzene from aniline, and further comprising a stripping column for stripping aniline from an aqueous stream. The first and second aqueous waste stream are provided to the stripping column, stripping aniline and nitrobenzene from the first and the aqueous waste stream, and the stripped aniline and nitrobenzene is provided to the aniline cleaning apparatus. | 2012-03-29 |
| 20120078016 | Methods of Synthesizing 2-Substituted-1,4-Benzenediamine - Disclosed is a method of making a 2-substituted-1,4-benzenediamine by nucleophilic aromatic substitution. | 2012-03-29 |
| 20120078017 | METHODS FOR PREVENTING AND TREATING RADIATION-INDUCED EPITHELIAL DISORDERS - The present invention provides methods of protecting irradiated eukaryotic cells such as irradiated mammalian epithelial cells, from the deleterious effect of microbial pathogens such as | 2012-03-29 |
| 20120078018 | Process For Neutralizing An Unneutralised Polyether Polyol - A process for neutralizing an unneutralised polyether polyol prepared using a base catalyst according to the invention comprises the steps of addition of a polyprotic acid to the unneutralised polyether polyol, the highest pKa-value of the polyprotic acid being less than 3.5, wherein, per kilogram of unneutralised polyether polyol, “A” moles of said polyprotic acid are added to the unneutralised polyether polyol, such that | 2012-03-29 |
| 20120078019 | METHOD FOR PRODUCING MONOHYDROXYPOLYALKYLENE OXIDES - The present invention relates to a process for the preparation of monohydroxypolyalkylene oxides (MPAO) which are substantially free of diols, comprising the reaction of at least one monoalcohol as a starter with at least one alkylene oxide in the presence of at least one basic catalyst, the catalyst being used as a solution in water or alcohol or in solvent mixtures which comprise water and/or alcohol. | 2012-03-29 |
| 20120078020 | PROCESS FOR THE MANUFACTURE OF HYDROFLUOROOLEFINS - In this invention we are disclosing a process for the synthesis of hydrocchlorofluoro olefins (HCFO) and/or hydrofluoroolefins (HFO). The process is based on the steps of fluorination of hydrochloropropenes or hydrochloropropanes to form hydrochlorofluoropropenes and/or hydrofluoropropenes, followed by gas phase, catalytic fluorination of the hydrochlorofluoropropenes to form hydrofluoropropenes. | 2012-03-29 |
| 20120078021 | ANTI-AGGLOMERATE GAS HYDRATE INHIBITORS FOR USE IN PETROLEUM AND NATURAL GAS SYSTEMS - A method of inhibiting gas hydrate formation in petroleum and natural gas production systems through the use of low dosage hydrate inhibitors which include reaction products of non-halide-containing inorganic acids, organic acids, and organic amines. The use of these non-halide-containing reaction products rather than chloride containing acids or alkylating agents avoids corrosion and stress cracking caused by residual inorganic chloride and other inorganic, halide-containing acids. The anti-agglomerate compositions can be administered continuously to effectively inhibit gas hydrate formation. In preferred embodiments, the anti-agglomerate compositions are mixtures of reaction products of non-halide-containing organic acids and organic amines. | 2012-03-29 |
| 20120078022 | METHOD FOR PRODUCING OLEFIN DIMER, AND OLEFIN DIMER - The process for producing an olefin dimer of the present invention includes a first step of carrying out a dimerization reaction of an olefin in the presence of a solid phosphoric acid catalyst in which phosphoric acid is supported on inorganic support particles at a reaction temperature of 55 to 300° C. by introducing into a reactor an olefin-containing raw material containing water in an amount of 10 ppm by mass or more and less than the saturated water content at the reaction temperature, thereby preparing a reaction product containing an olefin dimer, a second step of washing the reaction product prepared in the first step at a temperature of 50° C. or higher using an alkaline substance-containing water adjusted to pH 8 to 13 and a third step of washing the reaction product after the alkaline washing in the second step with water at a temperature of 0 to 110° C., thereby preparing an olefin dimer. | 2012-03-29 |
| 20120078023 | PROCESS FOR THE PREPARATION OF HYDROCARBONS FROM SYNTHESIS GAS - A process for the preparation of hydrocarbon products comprising the steps of (a) providing a synthesis gas comprising hydrogen, carbon monoxide and carbon dioxide; (b) reacting the synthesis gas to an oxygenate mixture comprising methanol and dimethyl ether in presence of one or more catalysts which together catalyse a reaction of hydrogen and carbon monoxide to oxygenates at a pressure of at least 4 MPa; (c) withdrawing from step (b) the oxygenate mixture comprising amounts of methanol, dimethyl ether, carbon dioxide and water together with unreacted synthesis gas and introducing the entire amount of the oxygenate mixture without further treatment into a catalytic oxygenate conversion step (d); (d) reacting the oxygenate mixture in presence of a catalyst being active in the conversion of oxygenates to higher hydrocarbons; (e) withdrawing an effluent from step (d) and separating the effluent into a tail gas, a liquid hydrocarbon phase containing the higher hydrocarbons produced in step. (d) and a liquid aqueous phase, wherein the pressure employed in steps (c) to (e) is substantially the same as employed in step (b). | 2012-03-29 |
| 20120078024 | Removal of Hydrogen From Dehydrogenation Processes - A process and system for dehydrogenating certain hydrocarbons is disclosed. The process includes contacting a dehydrogenatable hydrocarbon with steam in the presence of a dehydrogenation catalyst to form hydrogen and a dehydrogenated hydrocarbon. Some of the hydrogen is then removed and some of the remaining dehydrogenatable hydrocarbon is dehydrogenated. | 2012-03-29 |
| 20120078025 | USE OF A DIRECT HEATING DEVICE WITH A REHEATER IN A DEHYDROGENATION UNIT - Methods and processes for increasing the efficiency and/or expanding the capacity of a dehydrogenation unit by use of at least one direct heating unit are described. | 2012-03-29 |
