13th week of 2014 patent applcation highlights part 46 |
Patent application number | Title | Published |
20140087309 | OLEFIN-TRIGGERED ACID AMPLIFIERS - There are disclosed olefinic acid amplifier triggers and methods of using these compositions in, for example, photolithography. | 2014-03-27 |
20140087310 | PATTERN FORMING METHOD, ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, RESIST FILM, METHOD FOR MANUFACTURING ELECTRONIC DEVICE, AND ELECTRONIC DEVICE - A pattern forming method comprises (i) a step of forming a film by using an actinic ray-sensitive or radiation-sensitive resin composition containing: (A) a resin containing a repeating unit having a group capable of decomposing by the action of an acid to produce a polar group, (B) a compound capable of generating an acid upon irradiation with an actinic ray or radiation, and (C) a solvent, (ii) a step of exposing the film, and (iii) a step of developing the exposed film by using an organic solvent-containing developer to form a negative pattern, wherein the content of a repeating unit represented by the following formula (I) is less than 20 mol % based on all repeating units in the resin (A) and the resin (A) contains a repeating unit having a non-phenolic aromatic group other than the repeating unit represented by the specific formula. | 2014-03-27 |
20140087311 | DEVELOPABLE BOTTOM ANTI-REFLECTIVE COATING - The present invention provides a cross-linking agent capable of preventing formation of scum from a bottom anti-reflective coating, and also provides a composition for forming a bottom anti-reflection coating containing the agent. The cross-linking agent is a nitrogen-containing aromatic compound having at least one vinyloxy group or N-methoxymethylamide group, and the composition contains the cross-linking agent. The cross-linking agent of the formula (1) can be produced by reaction of a nitrogen-containing aromatic compound, a halogen compound having a vinyloxy group or N-methoxymethylamide group and a basic compound. | 2014-03-27 |
20140087312 | METHOD FOR MANUFACTURING OF ORGANIC LIGHT EMITTING DISPLAY DEVICE - Disclosed is a method of manufacturing an organic light emitting display device. The method include forming a driving thin film transistor and passivation layer on a substrate, forming a bank layer at a boundary portion between adjacent sub-pixels, on the passivation layer, laminating a first photoresist film on the bank layer, forming a first photoresist pattern by irradiating IR light on the first photoresist film in an area except a first sub-pixel, depositing a first organic emission layer in the first sub-pixel area exposed by the first photoresist pattern, removing the first photoresist pattern, laminating a second photoresist film on the bank layer, forming a second photoresist pattern by irradiating IR light on the second photoresist film in an area except a second sub-pixel, depositing a second organic emission layer in the second sub-pixel area exposed by the second photoresist pattern, and removing the second photoresist pattern. | 2014-03-27 |
20140087313 | STRIPPING SOLUTION FOR PHOTOLITHOGRAPHY AND PATTERN FORMATION METHOD - A stripping solution for photolithography which can effectively strip away residual materials of a photoresist pattern and etching residual materials, and has excellent anticorrosion properties on SiO | 2014-03-27 |
20140087314 | HEAT RETAINING HOOD ASSEMBLIES, AIR CURTAIN DESTRUCTORS WITH HEAT RETAINING HOOD ASSEMBLIES, AND METHODS FOR USING THE SAME - Heat retaining hood assemblies include a plenum with an interior side and an exterior side, wherein the plenum restricts heat from flowing from the interior side to the exterior side, and an exhaust duct fluidly connected to the exterior side of the plenum, wherein the plenum includes one or more contours to direct the exhaust on the interior side to an intake opening of the exhaust duct, and wherein the exhaust flows from the intake opening to a release vent of the exhaust duct disposed on the exterior side of the plenum. | 2014-03-27 |
20140087315 | Fire Igniter - A fire igniter uses a chemical reaction of two components, such as glycerin and powdered potassium permanganate, to create a flame. The glycerin may be contained within a crushable vial. The powder may be contained within a sleeve along with the vial, to form a fuel cell. The fuel cell may be contained within an outer cover. Flammable material may be contained with the fuel cell, and is ignited when the fuel cell is broken to create a flame. The fuel cell may alternatively be contained within a housing, which may be formed of a pair of housing sections that are releasably secured together to define an interior compartment. The housing sections are separable to enable the fuel cell to be removed from the compartment. Alternatively, the fuel cell may be contained within an actuable housing assembly that acts as both a package and an actuator. | 2014-03-27 |
20140087316 | Method and System for Heat Recovery from Products of Combustion and Charge Heating Installation Including the Same - A plurality of independently flow rate-controlled flows of fuel may be preheated at a heat exchanger (or both oxidant and fuel at separate heat exchangers) by heat exchange with a hot shell-side (heat transfer) fluid. The separate flows of hot fuel are directed to associated separate burners where they combust with flows of fuel to produce hot combustion gases. The hot combustion gases are used to preheat the hot shell-side fluid at a recuperator or regenerator. | 2014-03-27 |
20140087317 | Candle Wick Kit and Methods of Using the Same - The present invention relates to a kit, specifically a candle wick kit and methods of using the same. More specifically, the present invention comprises a kit including a number of components to utilize a candle after a wick inside the candle becomes unusable. For example, the present invention comprises one or more boring tools for creating a borehole through a quantity of candle wax, and one or more lengths of wick, one of which may fit within the borehole created by the boring tool. Thus, a candle having an unusable wick may be provided with a replacement wick for continued utilization of the candle. | 2014-03-27 |
20140087318 | Metallic Wick Assembly - A metallic wick assembly includes at least one mesh member and a sleeve member. The at least one mesh member includes a first length defined between first and second ends thereof. The sleeve member is mounted around the mesh member and includes a second length defined between two longitudinal opposite ends thereof. The second length is less than the first length. A third length is defined between a distal end of the sleeve member and the first end of the mesh member. The sleeve member is slidable with respect to the mesh member to adjust the third length for controlling the flame scale. | 2014-03-27 |
20140087319 | Method and Device for Producing Cement Clinker - In a device for baking of clinker in a clinker, the heat generated in the furnace can be used in a particularly efficient and versatile manner if heat generated in the furnace is transferred, by means of a first heat exchanger, to a heat carrier fluid, the heated heat carrier fluid is transported through at least one line to at least one second heat exchanger, and the heat is then discharged to a heat sink, for example in order to heat a flow of flue gas to a temperature required for the dentitrifiaction thereof. | 2014-03-27 |
20140087320 | METHOD OF REHEATING RAIL WELD ZONE - A method of reheating a rail weld zone after rails were welded, a distance C between a reheating region P of a rail web portion | 2014-03-27 |
20140087321 | ACTIVE COOLING REGULATION OF INDUCTION MELT PROCESS - Various embodiments provide methods and apparatus for active cooling regulation of a melting process. In one embodiment, a meltable material can be melted in a vessel that includes cooling channel(s) configured therein. A contact temperature T | 2014-03-27 |
20140087322 | Method and System for Heat Recovery from Products of Combustion and Charge Heating Installation Including the Same - A plurality of independently flow rate-controlled flows of oxidant may be preheated at a heat exchanger (or both oxidant and fuel at separate heat exchangers) by heat exchange with a hot shell-side (heat transfer) fluid. The separate flows of hot oxidant are directed to associated separate burners where they combust with flows of fuel to produce hot combustion gases. The hot combustion gases are used to preheat the hot shell-side fluid at a recuperator or regenerator. | 2014-03-27 |
20140087323 | SYSTEM AND METHOD FOR DIGITAL TOOTH IMAGING - Method and system for managing multiple impressions of a patient's jaw for an orthodontic treatment is provided. The method includes scanning at least a first impression and a second impression of same jaw for the orthodontic treatment; determining if the first jaw impression and the second jaw impression have distortion in different areas; selecting the first jaw impression or the second jaw impression as a base impression; and replacing a distorted tooth data from the base impression with data for the same tooth from a non-base impression. The method also includes scanning at least a first jaw impression for the orthodontic treatment; scanning a bite impression for the orthodontic treatment; matching the scanned first jaw impression with the scanned bite impression; comparing bite information with a tooth occlusal surface; and determining if reconstruction is to be performed on the tooth occlusal surface. | 2014-03-27 |
20140087324 | TOOTH MOVEMENT MEASUREMENT BY AUTOMATIC IMPRESSION MATCHING - The present invention relates to systems and methods for detecting deviations from an orthodontic treatment plan. One method includes receiving a tracking model, performing a matching step between individual teeth in a plan model and the tracking model, comparing the tracking model with the plan model, and detecting one or more positional differences. | 2014-03-27 |
20140087325 | COMPOSITE MATERIAL FOR MEDICAL DEVICES AND METHOD OF MANUFACTURING THE SAME - A composite material for medical devices includes a superelastic shape memory alloy configured or constituting a matrix and a metal oxide which is dispersed in the matrix. | 2014-03-27 |
20140087326 | APPARATUS AND METHOD FOR DENTAL IMPLANT FIXTURE LOCATION DETERMINATION - An apparatus for accurate dental implant fixture location determination including an inductive Eddy current effect based dental implant fixture location sensor and a handle. For detection and determination of the dental implant fixture location, the apparatus with the sensor is inserted into a patient mouth and moved in a scanning motion over the gums into which one or more dental implant fixtures have been earlier inserted. | 2014-03-27 |
20140087327 | PROSTHETIC TOOTH SUPPORT - Prosthetic tooth support ( | 2014-03-27 |
20140087328 | DENTAL SUCTION TUBING - A dental suction tube having a plurality of apertures in a distal portion of the tube is provided. The apertures are provided in a pattern to allow suction performance even when a portion of the distal end of the tube is abutting a portion of the mouth or other item during a dental procedure. | 2014-03-27 |
20140087329 | DRIVE MOTOR OF DENTAL HANDPIECE - A drive motor of a dental handpiece for driving a cutting tool of the handpiece is provided that is connected to the dental handpiece on its front end side and includes a cylindrical casing; a rotor unit, which is rotatably supported inside the casing and outputs a driving force; a stator unit provided around the rotor unit inside the casing; and an air path which causes cooling air supplied from the rear end side of the drive motor to pass through an airtight cooling room circumferentially extending between the stator unit and the casing, and to be discharged from the rear end side. | 2014-03-27 |
20140087330 | DENTAL RETRACTION CORD FACILITATING ABSORPTION AND BLOOD CLOTTING - A retraction cord for use in a dental procedure for widening the gingival sulcus containing kaolin. The kaolin acts as a hemostatic agent and an absorber or hydrophilic agent to reduce bleeding and dry the gingival sulcus. A binder may be used to aid in retention of the kaolin on the fibers of the retraction cord. A lubricant or release agent may be used preventing blood clots from sticking to the retraction cord upon removal. Kaolin is affected and has no adverse side effects. | 2014-03-27 |
20140087331 | DENTAL IMPLANT HAVING A FIRST, CONICAL, SCREW PART AND A SECOND, CYLINDRICAL, SCREW PART - The invention relates to a dental implant having a first conical screw part and a second cylindrical screw part, wherein the first screw part has a progressive thread and the second screw part has a fine thread and there is a circumferential groove at the thread termination of the fine thread, wherein the implant has a hexagon socket at the cervical end, the hexagon socket being arranged in a conical recess. | 2014-03-27 |
20140087332 | MULTILAYER MOUTHPIECE, MANUFACTURING METHOD AND MANUFACTURING DEVICE THEREOF - The present invention has aimed to provide a multilayer mouthpiece for rubbing teeth and gums to supply stimulation thereto. | 2014-03-27 |
20140087333 | PERIODONTAL TREATMENT SYSTEM AND METHOD - Methods and apparatuses for treating a root canal in a tooth or hard and/or soft tissue within a tooth and surrounding tissues by pulsing a laser light into a reservoir, preferably after introducing liquid fluid into the reservoir, so as to disintegrate, separate, or otherwise neutralize pulp, plaque, calculus, and/or bacteria within and adjacent the fluid reservoir without elevating the temperature of any of the dentin, tooth, bones, gums, other soft tissues, other hard tissues, and any other adjacent tissue more than about 5° C. | 2014-03-27 |
20140087334 | DEVICE FOR SPATIALLY MOVING PERSONS - A device for spatially moving persons includes a first support element, which includes a retaining device for at least one person and which is rotatable about a first rotational axis relative to a second support element. A second support element rotatably mounted about a second rotational axis relative to a third support element. The first rotational axis and the second rotational axis are substantially orthogonal to each other. The device further includes an image playback surface. The retaining device has at least one rotational degree of freedom relative to the image playback surface. | 2014-03-27 |
20140087335 | Motor Vehicle Operating Data Collection and Analysis - A method and apparatus for collecting and evaluating powered vehicle operation utilizing on-board diagnostic components and location determining components or systems. The invention creates one or more databases whereby identifiable behavior or evaluative characteristics can be analyzed or categorized. The evaluation can include predicting likely future events. The database can be correlated or evaluated with other databases for a wide variety of uses. | 2014-03-27 |
20140087336 | PHYSIOLOGY AND EXERCISE MANAGEMENT SYSTEM BASED ON BODY WEIGHT DIFFERENCE AND HEARTBEAT RATE - A physiology and exercise management system based on body weight difference and heartbeat rate uses a common portable electronic device in line with a built-in APP imputation software program to impute a user's basal metabolic rate (BMR) and ideal calorie intake according to a difference value between the user's current body weight and an international standard body mass index (BMI) and then uses a heartbeat rate range to detect the user's calorie consumption situation and a concise balance chart to learn the relation between the user's calorie intake and total calorie consumption values, and increase or decrease of personal body weight, so that a specific user can manage and maintain the best physiological condition for a long term effectively according to the body type and exercise purpose. | 2014-03-27 |
20140087337 | Persian alphabet teaching and learning game and method thereof - A teaching and learning chess-based game designed to help teach and learn the letters, and sequence of alphabet, as well as dictation of words written in the Persian (Farsi) alphabet, Persian alphabet including 32 characters and being | 2014-03-27 |
20140087338 | METHODS AND SYSTEMS FOR TRANSLATION - Latin-derived letters may be converted into Arabic letters by performing processing associated with causing, with a display module in communication with a processor circuit and a display, the display to display a wheel comprising a Latin-derived letter and a corresponding Arabic letter; performing processing associated with receiving, with a UI module in communication with the processor circuit and an input device, a selection of a Latin-derived letter via the input device; and performing processing associated with causing, with the display module, the display to display an Arabic letter corresponding to the Latin-derived letter in a window on the wheel. | 2014-03-27 |
20140087339 | TOILET TARGET AND REWARD APPARATUS - A toilet training aide formed of a flushable, biodegradable material comprising a multi-layer pocket with a latent image revealed by locating the toilet training aide under a stream of liquid or urine, the toilet training aide further including a tab portion used to maintain the toilet training aide in a fixed position in the toilet bowl. | 2014-03-27 |
20140087340 | VESTIBULAR STIMULATION SYSTEMS AND METHODS - A vestibular stimulation system, computer controls, methods, and doses are provided. | 2014-03-27 |
20140087341 | EXERCISE TRAINING SYSTEM - An exercise training system for facilitating tempo-based exercising using a computing device. The system includes a music library module having a plurality of selectable music files stored in a data storage device. The system includes a video instruction library module including a plurality of selectable video instruction files stored in a data storage device. The system includes a builder module to manage organization of selected music files and video instruction files into a coordinated music stream and a coordinated video instruction stream using a processor. The system includes a tempo registration module for selectably altering an effective tempo of each of the music stream and the video instruction stream to each match a selectable desired tempo using a processor. The system includes a tempo selection module to permit a user to select a value for the desired tempo. | 2014-03-27 |
20140087342 | TRAINING AND TESTING SYSTEM FOR ADVANCED IMAGE PROCESSING - Techniques for providing medical image processing training are described herein. According to one embodiment, at least one medical image associated with a medical image processing training course (MIPTC) is displayed in a first display area. An instruction is displayed in a second display area, where the instruction requests a user to perform a quantitative determination on at least a portion of a body part within the medical image displayed in the first display area. In response to a user action from the user, the requested determination is performed on the displayed medical image. It is determined automatically without user intervention at least one quantitative value representing a result of the user action. The quantitative value is compared to a predefined model answer. | 2014-03-27 |
20140087343 | AUSCULTATION TRAINING DEVICE AND RELATED METHODS - An auscultation system is disclosed herein. The auscultation system includes an auscultation device. The auscultation system also includes a proximity device operable to detect the proximity of the auscultation device. The proximity device can also emit a signal in response to detection of the auscultation device. The auscultation system also includes a first database storing a plurality of sound files. The auscultation system also includes a first controller operable to communicate with the proximity device and receive the signal. The first controller is also operable to select one of the sound files and transmit the selected sound file to the at least one speaker in response to receipt of the signal from the proximity device. | 2014-03-27 |
20140087344 | Apparatus and Method for Demonstrating Surgical Procedures Using Dead Body Organs - An anatomical training apparatus secures a body organ for demonstrating and training a surgical procedure on a body organ. Tubes extend from apertures in a base to orifices in the body organ to stabilize the body organ for surgical training. Training heart surgery is further improved by extending tubes to veins and arteries to not only stabilize the heart for demonstrating surgical techniques, but for forcing fluids to flow through the heart during the training. | 2014-03-27 |
20140087345 | SURGICAL TRAINING MODEL FOR LAPAROSCOPIC PROCEDURES - A surgical training model that includes a simulated tissue having a tubular shape that is connected to a tissue holder is provided. A portion of the simulated tissue overhangs the distal end of the tissue holder to simulate a cuff-like entry to the vaginal vault or resected intestine suitable for practicing laparoscopic closure of the vaginal vault, intestine or other organ via suturing or stapling. Two concentric tubular structures are also arranged over the same tissue holder. A second model includes two portions of simulated tissue that are held by two holders such that the simulated tissues are adjacent making the model suitable for practicing different types of anastomosis procedures. A third model includes two holders with a single or double tubular simulated tissue structure connected to and spanning a gap between the holders. The model isolates the step of closing a cylindrical opening for the purpose of repeated practice. | 2014-03-27 |
20140087346 | SURGICAL TRAINING MODEL FOR LAPAROSCOPIC PROCEDURES - A surgical training model that includes a simulated tissue having a tubular shape that is connected to a tissue holder is provided. A portion of the simulated tissue overhangs the distal end of the tissue holder to simulate a cuff-like entry to the vaginal vault or resected intestine suitable for practicing laparoscopic closure of the vaginal vault, intestine or other organ via suturing or stapling. Two concentric tubular structures are also arranged over the same tissue holder. A second model includes two portions of simulated tissue that are held by two holders such that the simulated tissues are adjacent making the model suitable for practicing different types of anastomosis procedures. A third model includes two holders with a single or double tubular simulated tissue structure connected to and spanning a gap between the holders. The model isolates the step of closing a cylindrical opening for the purpose of repeated practice. | 2014-03-27 |
20140087347 | SURGICAL TRAINING MODEL FOR LAPAROSCOPIC PROCEDURES - A surgical training device includes a model comprising a simulated tissue portion mounted in selectable tension onto a plurality of posts connected to a base. Each post includes at least one notch configured for retaining the simulated tissue portion. Mounting the simulated tissue portion that is in the form of a sheet in notches of different heights creates an angled installation of simulated tissue upon which surgical techniques such as cutting and suturing can be practiced in a simulated laparoscopic environment. More than one sheet can be mounted and each sheet can be mounted with selectable tension by pulling the sheet more or less as desired onto the posts. One variation includes a simulated tumor disposed between sheets, angled or wobbly posts and textured and imprinted simulated tissue surfaces to provide various levels of dynamism and difficulty for surgical skills training in a laparoscopic environment. | 2014-03-27 |
20140087348 | SURGICAL TRAINING MODEL FOR LAPAROSCOPIC PROCEDURES - A surgical training device is provided. The training device includes a practice model comprising a base with a plurality of eyelets connected to the outer surface of the base. The plurality of eyelets defines at least one predetermined pathway for practicing the passing of at least one needle and suture through the eyelets of the predetermined pathway. Various eyelets are described including angled, flexible, deflectable, interchangeable, retractable, rotatable and ones having apertures of various shapes and sizes. The predetermined pathway is marked with markings on the outer surface of base or with color-coded eyelets. Suture pathways define anatomical pathways as well as differing skill levels. The model provides a platform for practicing hand-to-hand transfer and depth perception among other skills required in laparoscopic procedures. | 2014-03-27 |
20140087349 | EMBEDDABLE VIDEO PLAYING SYSTEM AND METHOD - An embeddable video playing system and method. A user interface executing the method generates a display window for displaying video content to teach a course. The course includes a plurality of selectable lessons. The method displays a play control to play the video content and control bars to play several time-coded segments associated with the lesson. The method might also display an embedded exercise link, file attachment link and communication interface link. | 2014-03-27 |
20140087350 | INTERACTIVE TEST PREPARATION PLATFORM - An interactive test preparation platform that provides test problems and solutions in an interactive and enhanced manner. For example, the platform can provide an interactive problem and solution user interface that presents solution notations across different selectable problem screens in a manner that enhances the user's understanding of the problem and solution. The platform can enable the user to launch via the user interface multiple videos that explain the solutions to a particular problem in an efficient and bandwidth sensitive manner. The platform can also provide a navigation user interface that enables a user to locate items of interest in a quick and efficient manner by dynamically ordering the items in response to a selected item characteristic. | 2014-03-27 |
20140087351 | COMPUTER-BASED APPROACH TO COLLABORATIVE LEARNING IN THE CLASSROOM - A system for providing educators an approach to peer learning that helps students develop skills in specific content areas and build their self-efficacy: (a) collaborative, (b) reward-based educational techniques, and (c) teacher feedback on skill building effectiveness in the classroom environment. The configurable problem settings, problem generator, leveling milestones, classroom configurations, game play, and reporting analytics are made available through a Web portal to those involved with the subject children for which the programs are intended. Additionally, the portal allows for access to on-line reward based point program, a program comprised of a pool of merchants that partner with the present system program to allow exchange of products or discounts on their respective products for participants in the present system program. Players in the game receive virtual rewards for participation. | 2014-03-27 |
20140087352 | COMPUTER SYSTEMS FOR CAPTURING STUDENT PERFORMANCE - A method of capturing student performance can be provided that includes enabling a course creator to generate assessment data related to learning assessments for an online course and to generate learning outcomes for the online course, associating the assessment data with the learning outcomes, such that at least some of the learning assessments correspond to at least some of the learning outcomes, and generating an online classroom. The method may further include providing the learning assessments to students enrolled in the online course using the online classroom, wherein the students can generate completed learning assessments, and determining, for each of the completed learning assessments, whether one or more of the learning outcomes were met by each of the students. | 2014-03-27 |
20140087353 | Systems and Methods for Evaluating Technical Articles - The system includes an evaluation server configured to receive an article from an author. The article is then distributed to one or more reviewers who are technically qualified to evaluate the article. Further, the reviewers are provided with a scorecard that provides for specific aspects to be evaluated. Each reviewer completes his or her evaluation and submits his or her scores to the evaluation server. The evaluation server compiles the scores from each of the reviewers and calculates an aggregate score for the article. The server may be further configured to match the submitted articles with various technical journals that may be interested in the article. The server may give journals the ability to monitor articles that come through the process and that match a set of journal-definable requirements. The system may also provide authors with a list of matching journals. | 2014-03-27 |
20140087354 | Systems and Methods for Evaluating Technical Articles - The system includes an evaluation server configured to receive an article from an author. The article is then distributed to one or more reviewers who are technically qualified to evaluate the article. Further, the reviewers are provided with a scorecard that provides for specific aspects to be evaluated. Each reviewer completes his or her evaluation and submits his or her scores to the evaluation server. The evaluation server compiles the scores from each of the reviewers and calculates an aggregate score for the article. The server may be further configured to match the submitted articles with various technical journals that may be interested in the article. The server may give journals the ability to monitor articles that come through the process and that match a set of journal-definable requirements. The system may also provide authors with a list of matching journals. | 2014-03-27 |
20140087355 | GAMING PLATFORM FOR THE DEVELOPMENT AND EXECUTION OF CUSTOMIZED GAMES AND GAME COMPONENTS - A computerized educational game includes multiple formats for questions on a variety of topics related to health, wellness and education and other topics. In one embodiment, questions and answers for the game are stored so that the individual questions can be downloaded in more than one format. For example, the questions and answers may be stored so that they can be answered as “fill in the blank” questions in which the user must supply an answer. The same question may be formatted as a multiple choice question, in which the user is required to select a correct answer from among a plurality of answers. The questions and answers may also be formatted for use in multiple game formats, e.g., a quiz game, a puzzle game, a choose-best-from-list game, a matching game, or a reverse quiz game in which an answer is supplied and the player guesses or selects the question. | 2014-03-27 |
20140087356 | METHOD AND APPARATUS FOR PROVIDING A CRITICAL THINKING EXERCISE - Disclosed herein is a software application that provides a “critical thinking exercise” that presents a problem, solvable by a user exercising critical thinking skills. Each critical thinking exercise conforms to an archetype (e.g., a framework or a set of specifications) based on which each critical thinking exercise is created by an author, for a user. The critical thinking exercise archetype facilitates the exercise of user critical thinking skills. The user can analyze a number of author specified investigation scenes, identify the problem, select author pre-defined hypotheses, and form arguments supporting or falsifying the hypotheses with user-selectable items such as: evidences, inferences, conclusions, and conclusion confidence levels provided in the critical thinking exercise by the author. A solved problem entails that collection of user-formed arguments that resolves the problem to the highest level of certainty possible. The framework also includes tools that facilitate the author in creating each critical thinking application. | 2014-03-27 |
20140087357 | Organ Transplant Solutions and Methods for Transplanting Organs - A preservation solution for organs waiting to be transplanted is disclosed; the method of using the solution in a transplantation procedure is also disclosed. The preservation solutions comprise a balanced isotonic aqueous solution comprising sodium, potassium, calcium, magnesium and bicarbonate ions in a physiologically acceptable amount, together with an effective amount of a mutein of the C5a anaphylatoxin which is a C5a receptor antagonist wherein the amino acid residue naturally occurring at sequence position 69 is mutated. | 2014-03-27 |
20140087358 | METHODS AND COMPOSITIONS FOR DETECTING RARE CELLS FROM A BIOLOGICAL SAMPLE - The present invention provides methods and compositions for isolating and detecting rare cells from a biological sample containing other types of cells. In particular, the present invention includes a debulking step that uses a microfabricated filters for filtering fluid samples and the enriched rare cells can be used in a downstream process such as identifies, characterizes or even grown in culture or used in other ways. The invention also include a method of determining the aggressiveness of the tumor or of the number or proportion of cancer cells in the enriched sample by detecting the presence or amount of telomerase activity or telomerase nucleic acid or telomerase expression after enrichment of rare cells. This invention further provides an efficient and rapid method to specifically remove red blood cells as well as white blood cells from a biological sample. | 2014-03-27 |
20140087359 | METHODS AND DEVICES FOR SAMPLE LYSIS - Disclosed herein are methods and systems for use in preparing a sample. The methods and systems may be used for lysing one or more structures in a sample (e.g., cells, viral particles, etc.). The methods and compositions may comprise a microfluidic chip or use thereof. The microfluidic chips disclosed herein may comprise (a) a substrate comprising a chamber, wherein at least one mechanical element may be located within the chamber; (b) a thermal element in contact with the chamber; and (c) at least one aperture within the surface of the substrate, wherein the aperture may be configured to insulate the chamber. | 2014-03-27 |
20140087360 | METHOD AND INSERT FOR DENSITY GRADIENT SEPARATION - An insert for a centrifuge tube suitable for use in density gradient separation is described. The insert includes a member sized to fit within the tube for dividing the tube into a top portion and a bottom portion. Optionally the insert has a support extending or depending from the member for positioning the member within the tube. At least two openings are located on the member so that a first opening is closer to a bottom end of the tube relative to a second opening when the insert is positioned in the centrifuge tube. Also described are methods for separating a target population of cells from a sample using the insert for a centrifuge tube. | 2014-03-27 |
20140087361 | SELECTIVE LYSIS OF CELLS BY IONIC SURFACTANTS - The present invention discloses methods, kits-of-parts, and devices for the selective lysis of eukaryotic cells in a sample comprising micro-organisms such as bacteria unicellular fungi. The selective lysis is obtained by incubating the sample in an ionic surfactant under alkaline conditions. | 2014-03-27 |
20140087362 | Methods for assessing effectiveness and monitoring oncolytic virus treatment - Diagnostic methods for in vivo and ex vivo detection of circulating tumor cells (CTCs) for the diagnosis and treatment of cancer are provided. The diagnostic methods employ oncolytic viruses alone or in combination with one or more tumor cell enrichment and/or detection methods. Combinations and kits for use in the practicing the methods also are provided. | 2014-03-27 |
20140087363 | METHOD FOR GENERATING, STORING, TRANSPORTING, ELUTING AND DETECTING CLINICAL RELEVANT INFORMATION IN PLASMA USING FILTER PAPER - The present invention relates to a method that enables simpler, easier and more accurate determination cell mediated immune (CMI) responses using the biomarker IP-10 together with a simple and safe “dried blood spot” filter paper method of storing and shipping samples. The method is useful for the diagnosis and prognostication of diseases and conditions that can be diagnosed and prognosticated by measuring correlates of IP-10. | 2014-03-27 |
20140087364 | METHOD AND KIT FOR DETERMINING THE TIME OF SEROCONVERSION OF A PATIENT INFECTED WITH A VIRUS - The present invention provides a method for determining the time of infection, and a method for determining if a microbial infection is in the early stages comprising the step of determining the ratio of in vitro stimulated anti-microbial immunoreactivity and un-stimulated anti-microbial immunoreactivity in blood samples from said subject and related kits. | 2014-03-27 |
20140087365 | IMMUNOCHROMATOGRAPHIC DETECTION METHOD CAPABLE OF DETERMINING SAMPLE WITHOUT SPECIMEN AS IMPROPERLY OPERATED SAMPLE AND TEST STRIP USED THEREWITH - An object of the present invention is to provide an immunochromatographic detection method comprising a step of detecting the failure to add a specimen and an immunochromatographic test strip comprising a means for detecting the failure to add a specimen. The inventers provides an immunochromatographic detection method and an immunochromatographic test strip capable of detecting the failure to add a specimen through a step and a means using an antibody solid-phased on an insoluble membrane for capturing the complex of a component (control component) contained in the specimen other than the analyte and a label to which an antibody to the component is immobilized so as to detect the presence or absence of the control component, in an immunochromatographic detection method of detecting an analyte in a sample acquired by diluting the specimen. | 2014-03-27 |
20140087366 | USE OF DIVALENT IONS, PROTEASES, DETERGENTS, AND LOW pH IN THE EXTRACTION OF NUCLEIC ACIDS - The present invention provides methods of extracting target nucleic acids from a biological sample using divalent salts and acidic conditions. | 2014-03-27 |
20140087367 | CHROMATOGRAPHY METHOD AND CHROMATOGRAPHIC KIT - The chromatography method includes a step of forming a composite with a test substance and a labeling substance containing a metal modified by a first binding substance of the test substance and then developing the composite on an insoluble carrier; a step of capturing the test substance and the labeling substance in a detection site on the insoluble carrier including a second binding substance of the test substance or a substance having a binding property to the first binding substance of the test substance; and a step of amplifying the captured labeling substance using a first amplification reagent and a second amplification reagent to detect the test substance. | 2014-03-27 |
20140087368 | Methods for Antimicrobial Resistance Determination - The present invention relates to methods and systems for determining the antibiotic-resistance status of microorganisms. The invention further provides methods for determining the antibiotic-resistance status of microorganisms in situ within a single system. | 2014-03-27 |
20140087369 | INFECTION DETECTION METHODS AND SYSTEMS AND RELATED COMPOUNDS AND COMPOSITIONS - A compound, or a pharmaceutically acceptable salt, ester, hydrate or solvate thereof, comprising formula I: | 2014-03-27 |
20140087370 | SAMPLE TREATMENT DEVICE, SAMPLE TREATMENT METHOD, AND REACTION CONTAINER FOR USE THEREIN - Reaction containers ( | 2014-03-27 |
20140087371 | Compositions and Methods for Detection of Clostridium Difficile - Methods for the rapid detection of the presence or absence of | 2014-03-27 |
20140087372 | PROBE, KIT, AND METHOD FOR DETECTING PATHOGENIC MICROORGANISM - Disclosed herein is a hairpin probe for detecting a target pathogenic microorganism in a sample. The hairpin probe includes a microbead and an oligonucleotide having its 3′-end coupled to the microbead. The oligonucleotide includes, from 5′ to 3′, a Tag sequence hybridizable to a specific identification sequence of the pathogenic microorganism, an internal control sequence having at least four words each having 4 nucleotides with a 75% AT-content, an anti-Tag sequence being a reverse complement of the Tag sequence, and a tail having at least two consecutive thymidine residues. The Tag and anti-Tag sequences are operable to form a stem of the hairpin probe with the internal control sequence being a loop. Also disclosed herein are, a kit including the hairpin probe and a method for using the kit in the detection of a target pathogenic microorganism. | 2014-03-27 |
20140087373 | Enclosed unit for rapid detection of a target nucleic acid amplification product - The invention relates to a method for rapid detection of a target nucleic acid amplification product while preventing cross-contamination between target nucleic acid amplification products and avoiding false positives, comprising the steps of: a) leaving the reaction tube unopened after the amplification reaction is finished, so as to prevent the target nucleic acid amplification product from leaking out and resulting in contamination; b) placing the unopened reaction tube inside an enclosed unit, making the target nucleic acid amplification product be transferred to a test strip from the reaction tube in a physically enclosed environment; c) performing detection in a visual read-out manner, and determining the result; d) discarding the enclosed unit in a safety place as a whole without opening it after the detection. The invention also relates to a totally enclosed unit for detecting a target nucleic acid amplification product, and still relates to applications of the totally enclosed rapid detection unit in detection of infectious pathogens, food industry, agriculture, livestock husbandry, customs quarantine control, and determination of DNA. | 2014-03-27 |
20140087374 | The Use of Microfluidic Systems in the Electrochemical Detection of Target Analytes - The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes. | 2014-03-27 |
20140087375 | BIOPROBES AND METHODS OF USE THEREOF - Disclosed are biomolecule based bioprobes that exhibit improved water solubility and monolayer-forming properties with substantially little or no aggregation that can appreciably interfere with binding of the bioprobes to a target nucleotide. The bioprobes may be used in conjunction with a suitable reporter system to detect very small quantities of biological markers. The bio-probes comprise a nucleobase sequence capable of hybridizing to a target nucleotide; and at least one charged functional group attached to said nucleobase sequence. Also disclosed are biosensors, and sensing devices that comprise the bio-probe. Further disclosed are suitable electrochemical reporter systems for use with bioprobes. Methods of use of these devices and probes, including for the detection of target biomarkers, including biomarkers for cancer cells or pathogens, are also included. | 2014-03-27 |
20140087376 | METHODS OF DETECTING ANEUPLOIDY IN HUMAN EMBRYOS - Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans. | 2014-03-27 |
20140087377 | METHOD OF IDENTIFYING NUCLEIC ACID-CONTAINING OBJECT - The present invention relates to a method of identifying nucleic acid-containing object, more precisely a method of identifying nucleic acid-containing object which comprises the following steps: (1) preparing nucleic acid-containing object having the nucleotide sequence complementary to the nucleotide sequence of RNA-dual probe; (2) reacting the nucleic acid included in the object with the buffer containing the RNA-dual probe conjugated with a reporter and a quencher respectively and RNase; and (3) detecting fluorescence generated from the reporter. The method of identifying an object of the present invention provides labeling sensitivity 100 times as high as that of the conventional method using sequencing or labeling with fluorescent materials, takes advantages of shorter analysis time, facilitates different labeling on a variety of products according to fluorescent materials, and makes possible unlimited product administration by product group and batch in real production process by differentiating the nucleotide sequence of each oligonucleotide. | 2014-03-27 |
20140087378 | METHOD, PROBE AND KIT FOR DNA IN SITU HYBRIDATION AND USE THEREOF - The invention relates to a method for the detection of the occurrence of initiation of replication events in genomic DNA in a eukaryotic cell, involving contacting said eukaryotic cell comprising said genomic DNA with a first nucleotide probe, under conditions enabling in situ hybridization of said first nucleotide probe with a target region in the DNA genome, wherein said target region comprises a nucleic acid sequence which has no identified corresponding annealing RNA in a metabolically active cell and therefore remains RNA-free during transcription and replication of said DNA genome and detecting said first nucleotide probe hybridized to said DNA. Further detection of at least one RNA molecule can be achieved. The invention also relates to a nucleic acid molecule suitable for use as a probe, hybridizing with a target region in a eukaryotic genomic DNA, and comprising a nucleic acid sequence which has no identified corresponding annealing RNA in the metabolically active cell containing said eukaryotic genomic DNA and therefore remains RNA-free during transcription and replication of said DNA genome. The invention also encompasses kit(s) for carrying out in situ hybridization and use of the method(s), nucleic acid molecule(s) or kit(s) of the invention in the detection of mitochondrial disease(s), neoplasic diseases(s) or cancer(s), or in the testing of the cytotoxicity of organic or chemical compounds, especially drugs, on eukaryotic cells. | 2014-03-27 |
20140087379 | Electrochemical Polynucleotide Detection Comprising Ligation - Disclosed, for example, are methods comprising cleaving an uncleaved probe to form a cleaved oligonucleotide flap, forming a hybridization complex between the cleaved oligo-nucleotide flap, a bridging oligonucleotide, and a capture oligonucleotide that is immobilized on a surface, such that the oligonucleotide flap and the capture oligonucleotide are hybridized to immediately adjacent, complementary regions of the bridging oligonucleotide, ligating the oligonucleotide flap to the capture oligonucleotide to form an immobilized ligation product, and detecting the ligation product. | 2014-03-27 |
20140087380 | Mutation Detection Probe, Mutation Detection Method, Method of Evaluating Drug Efficacy, and Mutation Detection Kit - The present invention provides a probe for detecting a mutation in the ALK gene, which is at least one fluorescently labeled oligonucleotide selected from the group consisting of P1 to P4, P7 and P8 oligonucleotides; an application thereof; and an oligonucleotide for the application. | 2014-03-27 |
20140087381 | DOUBLE STRANDED LINEAR NUCLEIC ACID PROBE - A double-stranded nucleic acid hybridization probe and methods of using the same are described. The probe described is particularly suited for real-time RT-PCR reactions and has high tolerance to mismatches. | 2014-03-27 |
20140087382 | NORMALIZATION OF POLYMERASE ACTIVITY - Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase. | 2014-03-27 |
20140087383 | NUCLEIC ACID PROBES AND METHODS FOR DETECTING PLASMODIUM PARASITES - This invention relates to novel nucleic acid probes and methods for detecting | 2014-03-27 |
20140087384 | DISTINGUISHING PCA3 MESSENGER RNA SPECIES IN BENIGN AND MALIGNANT PROSTATE TISSUES - This invention concerns the discovery of two distinct PCA3 mRNA sequences. One of these sequences corresponds to a short PCA3 mRNA molecule whereas the other PCA3 RNA molecule is longer as it comprises an additional sequence between exon 3 and exon 4a. The short RNA is associated with prostate cancer whereas the long RNA sequence is associated with a non-malignant state of the prostate. Based on the differential expression levels of these two PCA3 RNA sequences, protocols for the diagnosis of prostate disease are provided. The invention also relates to therapeutic approaches to prostate cancer. | 2014-03-27 |
20140087385 | SYSTEM AND METHOD FOR CLEANING NOISY GENETIC DATA FROM TARGET INDIVIDUALS USING GENETIC DATA FROM GENETICALLY RELATED INDIVIDUALS - A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals. | 2014-03-27 |
20140087386 | METHODS AND SYSTEMS FOR PERFORMING DIGITAL MEASUREMENTS - Methods, devices and systems for performing digital measurements are provided. | 2014-03-27 |
20140087387 | Methods for the Treatment, the Prognostic Assessment and the Staging of Non-Small Cell Lung Cancer - The present invention relates to methods for the treatment, the prognosis and the diagnosis of non-small cell lung cancer. | 2014-03-27 |
20140087388 | Methods of Nucleic Acid Liquid-phase Extraction and Detection - The invention discloses a method of extracting nucleic acid analyte solution from biological sample, comprising: placing the biological sample into a heating container; optionally, adding solvent medium into the biological sample; heating the biological sample under high pressure; optionally, centrifuging the biological sample; and obtaining the solution including the nucleic acid analyte. The invention also discloses a method of detecting the nucleic acid analyte obtained by said extraction method. | 2014-03-27 |
20140087389 | DETECTION APPARATUS AND METHOD FOR THE AUTOMATIC DETECTION OF PARTICLES - A detection apparatus and method for the automatic detection of particles, in particular biological particles, in a sample. The detection apparatus comprises a detection device for recording the particles, and a fluidic device for automatically conveying the sample to the detection device. The fluidic device comprises a treatment device for the automatic treatment of the particles for the purpose of detection, and the detection device comprises a flow cytometer for recording at least one physical parameter of the treated particles. The detection method includes operations performed by the detection device, the fluidic device, the treatment device and the flow cytometer. | 2014-03-27 |
20140087390 | METHOD AND SYSTEM FOR ANALYSIS OF PROTEIN AND OTHER MODIFICATIONS ON DNA AND RNA - A protocol and system for determining sites at which proteins directly bind to DNA or RNA, modify other proteins including histones, or bind to other proteins as well as determining sites at which DNA or RNA is modified is described herein. A simplified, highly accurate method for studying protein interactions with DNA or RNA and sites of DNA or RNA modification using nanodetector systems is provided. | 2014-03-27 |
20140087391 | Detection of Tumor Stem Cells and Tumor Cells in Epithelial-Mesenchymal Transition in Body Fluids of Cancer Patients - The present invention relates to the detection of tumor stem cells and tumor cells in epithelial-mesenchymal transition and uses of such methods. According to the present invention said method comprises a selecting step for selection or enrichment of said predetermined cells from the sample wherein the sample is contacted with the solid surface for preferential binding of said predetermined cells to the solid surface and then the sample is removed d from the solid surface in a washing step. The inventive method is characterized in that the sample contains a polyol at least during one of contacting the sample with the solid surface and the washing step and in a detection step detecting in said cells, preferentially selected or enriched by said selecting step, the presence or absence of expression of at least one marker associate with at least one the group comprising tumor stem cells and tumor cells in epithelial-mesenchymal transition. | 2014-03-27 |
20140087392 | GLYCOSYL TRANSFERASE FROM CHINESE HAMSTER AND RELATED METHODS - A glycosyl transferase from Chinese hamster and related methods are described. | 2014-03-27 |
20140087393 | METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY HCG ASSAY - The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample. | 2014-03-27 |
20140087394 | Instrument Setup System for a Fluorescence Analyzer - The present invention reagents and methods for setting up an instruments having a multiplicity of detector channels for analyzing a multiplicity of fluorescent dyes. The present invention is particularly applicable in the field of flow cytometry. | 2014-03-27 |
20140087395 | METHOD FOR DISTINGUISHING BETWEEN SPECIES WITHIN THE GENUS STAPHILOCOCCUS - The object was to provide a method for distinguishing between species within the genus | 2014-03-27 |
20140087396 | Health Diagnostic Compact Disc - A modified health diagnostic compact disc (HDCD) comprising (a) a protective layer; (b) a reflective layer; (c) a dye layer (d) a polycarbonate layer; and (e) a micro fluidic layer. In a certain aspect, the polycarbonate layer of the HDCD contains a data layer. The micro fluidic layer of the HDCD is composed of polydimethylsiloxane (PDMS). The micro fluidic layer of the HDCD contains one or more donut-shaped trenches. The micro fluidic layer of the HDCD is associated with conjugated microparticles in solution. The HDCD further comprises integrated microneedles. The modified health diagnostic compact disc can be used by methods of the invention to identify and/or measure the presence of biologic cells utilizing a standard computer compact disk drive. | 2014-03-27 |
20140087397 | BIOMARKERS FOR FANCONI ANEMIA - A method for adjusting therapy given to a patient having cancer by diagnosing Fanconi Anemia (FA), and/or predicting bone marrow failure (BMF) or predicting cancer susceptibility in the patient by determining a level of at least one biomarker. In one embodiment the biomarker is at least one of 3-hydroxyisovalerate, acetate, isopropanol, glycerol-3-phosphocholine, choline, histamine, glutamate, alanine, glycine, isoleucine, lysine, phenylalanine, threonine, tyrosine, vitamin A, vitamin D, cholesterol, ketone bodies, acetone, and/or acetoacetate/acetoacetaldehyde. The biomarker level is assessed in a biological sample obtained from the patient, and an altered level of the biomarker, increased or decreased, compared to a family member not having FA or to a healthy control subject, is indicative of FA and/or predictive of BMF and cancer susceptibility. The information is used to adjust the patient's therapy based on the diagnosis of FA and/or prediction of BMF and cancer susceptibility in the patient. | 2014-03-27 |
20140087398 | OXIDIZED CARDIOLIPIN AND USES TO DETECT CARDIOLIPIN ANTIBODIES - Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized cardiolipin, alone or complexed with one or more attachment molecules, are useful to detect anti-lipoidal antibodies (such as IgG and IgM antibodies) in subjects, for example, when used in ELISA plates. ELISA plates are described that permit the detection of anti-lipoidal antibodies and that permit the co-detection of nontreponemal and treponemal antibodies in biological samples. | 2014-03-27 |
20140087399 | ASSAY METHOD FOR PEPTIDE SPECIFIC T-CELLS - A method of assaying for peptide-specific T-cells comprises adding peptide to a fluid sample of fresh peripheral blood mononuclear cells, and detecting a cytokine such as interferon-y produced by T-cells that have been pre-sensitised to the peptide. The assay method is quick and cheap and is expected to be useful for the study of various disease states including Hepatitis B, Hepatitis C, tuberculosis, malaria, HIV and influenza. | 2014-03-27 |
20140087400 | DIAGNOSIS AND PROGNOSIS OF TRIPLE NEGATIVE BREAST AND OVARIAN CANCER - In one aspect, the present disclosure provides a method of predicting disease progression comprising: (a) obtaining a sample of breast tissue that is estrogen receptor negative, progesterone receptor negative and does not over-express human epidermal growth factor 2 receptor protein; and (b) determining the expression of glia maturation factor beta, wherein expression of glia maturation factor beta is indicative of lymph node metastatis. In another aspect, the present disclosure provides a method of predicting disease progression comprising: (a) obtaining a sample of breast tissue that is estrogen receptor negative, progesterone receptor negative and does not over-express human epidermal growth factor 2 receptor protein; and (b) determining the expression of glia maturation factor beta, wherein expression of glia maturation factor beta is indicative of an untreated or treated prognosis that is reduced compared to an absence of the expression. | 2014-03-27 |
20140087401 | Biomarkers for Assessment of the Molecular Quality in Biospecimens - The present invention provides compositions and methods for assessing the amount of degradation in a biospecimen. The invention relates to the discovery that dynamic changes in protein biomarkers correlate to the amount of degradation in a biospecimen. The present invention also provides kits for assessing the amount of degradation in a biospecimen. | 2014-03-27 |
20140087402 | Synthetic luciferase gene and protein - A codon optimized and stabilized luciferase gene and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in mammalian cells, are disclosed. This new luciferase exhibits long-wavelength light emission, as well as improved thermostability and higher expression levels in mammalian cell systems, compared to native luciferase. Assays using this new enzyme for measuring various biological metabolic functions are described. | 2014-03-27 |
20140087403 | LOW-VOLUME COAGULATION ASSAY - Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 μL) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof. | 2014-03-27 |
20140087404 | METHOD FOR ASSAYING ARYLSULFATASE ACTIVITY - Provided is a method for determining activity of arylsulfatase in an aqueous system, which comprises a step in which arylsulfatase is subjected to reaction with a substrate, from which fluorophore or chromophore is liberated by suffering an action of the arylsulfatase, in an aqueous reaction system having high ionic strength. Also, provided are a lactase preparation having a lactase activity of 4,000 NLU/g or more according to the FCC IV method and having an arylsulfatase activity of 0.1% or less of the lactase activity as the basis, in which the arylsulfatase activity has been determined by the method for determining activity of arylsulfatase in an aqueous system according to the fluorescence method of the present invention; a method for producing this preparation; and a dairy product which comprises using this preparation. | 2014-03-27 |
20140087405 | MODIFIED ALPHA-GLUCOSIDASE AND APPLICATIONS OF SAME - The object is to provide an α-glucosidase in which a transglycosylation activity predominates, and use thereof, and the like. A modified α-glucosidase consisting of an amino acid sequence in which one or two or more of the amino acid(s) is selected from a group of specific amino acids. | 2014-03-27 |
20140087406 | SALMONELLA DETECTION ARTICLES AND METHODS OF USE - An article for detecting | 2014-03-27 |
20140087407 | Methods of Measuring Protein and/or Fat Digestibility and Uses Thereof - The present invention provides methods for continuous measurement of protein and/or triglyceride digestibility during a meal. Stable isotope of | 2014-03-27 |
20140087408 | INFORMATION ACQUISITION METHOD - The present invention relates to an information acquisition method of acquiring information of distribution of a protein or peptide in a sample based on mass information obtained by mass spectrometry of the protein or peptide. The method includes mass spectrometry of a definite region of the sample after limited proteolysis of the protein or peptide and acquisition of information relating to distribution using an ion peak that has a two-dimensional intensity distribution having a Pearson product-moment correlation coefficient of 0.5 to more and 1.0 or less in the definite region against the two-dimensional intensity distribution of the parent ion of the protein or the peptide subjected to the limited proteolysis and has a peak intensity ratio of larger than 1.0 against the peak intensity of the integrated spectrum of the parent ion in the definite region, wherein the m/z of the ion peak is greater than 500. | 2014-03-27 |