12th week of 2011 patent applcation highlights part 31 |
Patent application number | Title | Published |
20110070566 | Meal Planning System - A meal planning system may include first, second and third grocery lists, a plurality of first recipes and a plurality of second recipes. The second grocery list may be associated with the first grocery list. The first recipes may be associated with the second grocery list. Each of the first recipes may include food items from at least one of the first and second grocery lists. The second grocery list includes enough food items to prepare the first recipes. The third grocery list may be associated with the first grocery list. The second recipes may be associated with the third grocery list. Each of the second recipes may include food items from at least one of the first and third grocery lists. The third grocery list includes enough food items to prepare the second recipes. The grocery lists and recipes may be displayed on cards and/or an electronic device. | 2011-03-24 |
20110070567 | SYSTEM FOR PROFESSIONAL DEVELOPMENT TRAINING, ASSESSMENT, AND AUTOMATED FOLLOW-UP - Systems and methods for providing web-enabled professional development training to participants in diverse industries to thereby improve the participant's knowledge, skills, and proficiency. Professional development training is provided over the Internet. Following the training, at least one participant is provided with a first question set regarding the training. The participant is then allowed to implement concepts and principles according to the training previously received. After a predetermined period of time elapses, additional follow-up questions are generated based on the participant's responses to the first question set and the participant's implementation of training principles and concepts. The follow-up questions may then be presented to the participant via the Internet. In a further implementation, the follow-up questions may be presented to a supervisor of the participant. In some implementations, the Internet may be utilized to assess the participants performance prior to and after receiving training. | 2011-03-24 |
20110070568 | COMMUNICATION DEVICES AND METHODS OF USE - A device and system to facilitate communication between a first communicator and a second communicator to teach desired behaviors, values, principles, and skills. The device includes a plush or stuffed toy form having one or more pockets which are sized and configured to receive one or more communication symbols. The communication symbols may represent thoughts, feelings, actions, goals, behavior, values, or other concepts to be discussed by the first communicator and second communicator. First communicator/second communicator discussion occurs as the communication symbols are placed into and removed from the pockets. | 2011-03-24 |
20110070569 | GROUP EXERCISE PROGRAM UTILIZING FREE WEIGHT, MACHINE FITNESS ACCESSORY AND BODY MOVEMENT EXERCISE COMBINATION - The present invention is a group workout program that allows instructors to lead and teach multiple exercisers machine, free weight and other forms of exercise simultaneously. Participants within a single exercise area can do the same free weight, machine and accompanying exercises simultaneously. They can also circuit train in small, medium and large circuits doing the same or different exercises concurrently or simultaneously under the direction of an instructor. More than one exerciser can exercise on each machine at the same time and machines can be combined to deliver more exercises. An exerciser can do multiple exercises on a single machine either changing the configuration between exercises and also by leaving the configuration the same and simply moving between varying exercises. The workout program allows an instructor to teach exercises and exercise combinations in way where they can have a slow, medium, fast and mixed pace. The workout program method can be conducted simultaneously for participants of different fitness levels and experience and can be delivered for specific body parts or entire body workout programs. | 2011-03-24 |
20110070570 | ELECTRONIC TEACHING SYSTEM INCORPORATING MAGNETS IN AN INSULATING BASEBOARD - An insulating baseboard which contains within itself a number of embedded magnets, accessible from top and bottom surface, which locate and hold in place component holders on which can be located ferromagnetic rods which when assembled combine to create electronic circuits. The component holders include eyelet cores and may include electronic components which align themselves with the magnets embedded in the baseboard and in turn hold in place ferromagnetic rods positioned on top of the eyelet cores. The ferromagnetic rods lie in a horizontal plane above and in parallel with the insulating baseboard and in-line or at 90 degrees to each other when viewed from above to produce a working circuit that replicates standard schematic circuit diagrams. Non-friction vertical connections can be made by means of connecting wires having ferromagnetic ends and which are held in place within the hollow part of the eyelet core by magnetism. | 2011-03-24 |
20110070571 | METHOD AND SYSTEMS FOR IMPROVING FERTILITY - The present invention provides audio and audio-visual programming to assist women in improving fertility and chance of conception through a multi-faceted regimen designed for daily usage over a usage period that corresponds to the female reproductive system. The regimen utilizes the following: (i) stress reduction through auditory progressive body scanning, deep breathing and visualization of events that would intend to induce deep mental and physical relaxation; (ii) physiologically-based detailed guided visualization of what the reproductive cycle is accomplishing in that particular time of the cycle; and (iii) cognitive restructuring through reduction of negative thought patterns to improve emotional state and well-being. | 2011-03-24 |
20110070572 | INTERACTIVE EDUCATION SYSTEM AND METHOD - A digitally-based, multi-media learning center is provided for an interactive learning experience. An expert-guided digital presentation of relevant evidence-based information is provided, such as relating to medical conditions. In addition to digitally-based information, live peer-to-peer, and interpersonal interaction, including with live patients, is preferably supported to supplement the learning experience. | 2011-03-24 |
20110070573 | INSTRUCTIONAL CONTENT AND STANDARDS ALIGNMENT PROCESSING SYSTEM - An instructional content and standards alignment processing system is disclosed. The system includes a computer-readable memory configured to store information indicative of instructional content, a first educational standard, and a second educational standard, and configured to store at least one alignment between the instructional content and the first educational standard and at least one mapping between the first educational standard and the second educational standard. The system also includes a processor configured to automatically generate at least one alignment between the instructional content and the second educational standard based on the mapping between the first educational standard and the second educational standard. The computer-readable memory is configured to store the alignment between the instructional content and the second educational standard after the alignment is confirmed by a user. Methods and machine-readable mediums are also disclosed. | 2011-03-24 |
20110070574 | METHOD FOR VIRUS DETECTION - A method of determining the concentration of a virus or antigen thereof in a sample comprises the steps of: providing a sensor surface having immobilized thereto a virus antigen or a virus antigen analogue, mixing the sample with a known amount of antibody to the virus antigen to obtain a predetermined concentration of antibody to the antigen in the sample mixture, contacting the sample mixture with the sensor surface to bind free antibody in the mixture to the sensor surface, measuring the response of the sensor surface to the binding of free antibody, and determining the concentration of the virus or antigen in the sample from a calibration curve prepared by measuring the responses obtained for mixtures containing the predetermined concentration of antibody and different concentrations of virus. | 2011-03-24 |
20110070575 | Immunomodulatory Compositions, Combinations and Methods - The invention provides immunomodulatory compositions, immunomodulatory combinations, and methods of modulating TLR7-mediated biological activity. Generally, the immunomodulatory compositions include an immunomodulatory oligonucleotide in an amount effective to reduce TLR7-mediated biological activity. In some cases, an immunomodulatory combination can further include an IRM compound. In some of these embodiments, the IRM compound can be a TLR7/8 agonist. Generally, the Imethods include contacting immune cells with an immunomodulatory composition in an amount effective to reduce TLR7-mediated biological activity. | 2011-03-24 |
20110070576 | VITRO DIAGNOSTIC KIT FOR IDENTIFICATION OF HUMAN PAPILLOMAVIRUS IN CLINICAL SAMPLES - A method and kit for detection and typing of HPV in a sample are described, as is a reaction vessel for use in the method. Universal HPV primers are used to amplify a sample by PCR; the amplified sample is then hybridised to an array of HPV type-specific probes to determine the HPV type. | 2011-03-24 |
20110070577 | Method for Detecting Target Nucleic Acids Using Template Catalyzed Transfer Reactions - The present invention relates to the detection and quantification of nucleic acid sequences and to the sequence determination of nucleic acids using template catalyzed transfer reactions. The invention also relates to methods, reagents, and kits for detecting and quantifying nucleic acid sequences and for determining the sequence of nucleic acids. | 2011-03-24 |
20110070578 | DNA analyzer - Aspects of the disclosure provide a microfluidic chip to facilitate DNA analysis. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, a dilution domain coupled to the first domain to dilute a PCR mixture received from the first domain, and a second domain that is coupled to the dilution domain so as to receive the amplified DNA fragments. The second domain includes a separation channel that is configured to perform electrophoretic separation of the amplified DNA fragments. In addition, the disclosure provides a DNA analyzer to act on the microfluidic chip to perform an integrated single chip DNA analysis. | 2011-03-24 |
20110070579 | POLYKETIDE SYNTHASE-NONRIBOSOMAL PEPTIDE SYNTHETASE GENE - The objective is to provide a method for rapidly, and highly accurately performing genetic detection of the cyclopiazonic acid-producing ability in a strain belonging to genus | 2011-03-24 |
20110070580 | Methods, Compositions, and Kits for Amplifying and Sequencing Polynucleotides - In one aspect, there are provided methods of amplifying and sequencing a polynucleotide. In some embodiments, the method includes (a) amplifying the polynucleotide with at least one amplification primer, a processive amplification polymerase, a sequencing primer, a sequencing polymerase, deoxynucleoside triphosphates suitable for template-dependent primer extension, and one or more terminating nucleotides, the incubation being carried out at a first temperature suitable for amplifying the polynucleotide with the processive amplification polymerase; (b) incubating the product of step (a) at a second temperature suitable for forming a plurality of differently-sized extended sequencing primers with the sequencing polymerase; (c) evaluating the extended sequencing primers in order to determine the sequence of the polynucleotide. The reactions at the first and second temperatures can be carried out in a single reaction vessel. In other aspects, compositions and kits for carrying out the methods are also provided. | 2011-03-24 |
20110070581 | Separation of Leukocytes - Leukocytes (e.g., neutrophils, monocytes and/or lymphocytes) can be captured and separated from blood by removing platelets using a spiral channel, followed by capturing individual leukocyte types in a series of cell capture channels having leukocyte binding moieties. Accordingly, various microfluidic-based cell affinity chromatography methods can be used to separate leukocytes from whole blood. | 2011-03-24 |
20110070582 | Gene Expression Profiling for Predicting the Response to Immunotherapy and/or the Survivability of Melanoma Subjects - A method is provided in various embodiments for determining a profile data set for predicting the response top immunotherapy and or survivability of a subject with melanoma based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification under measurement conditions that are substantially repeatable for measuring the amount of RNA corresponding to at least 2, 3 or 4 constituents according to the gene models shown in Tables 2-3, 4-6 and 9. | 2011-03-24 |
20110070583 | Lsamp gene associated with cardiovascular disease - The LSAMP gene can be used for cardiovascular disease risk assessment, in particular Left Main Disease. The genetic risk attributable to LSAMP adds to known cardiovascular disease risk factors. Assessment of risk attributable to LSAMP permits early initiation of preventive and therapeutic strategies. Given the pronounced clinical risk associated with Left Main Disease, such risk assessment should significantly reduce morbidity and mortality. | 2011-03-24 |
20110070584 | METHODS AND COMPOSITIONS FOR DIAGNOSING AND MONITORING AUTOIMMUNE AND CHRONIC INFLAMMATORY DISEASES - Methods of diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis and kits or systems containing the same are also described. | 2011-03-24 |
20110070585 | INTEGRATED NUCLEIC ACID ANALYSIS - The present invention relates to an integrated method of nucleic acid analysis, and more particularly to a simplified sample pre-treatment, which renders the method more easily automated, where the sample is provided on or applied onto a solid matrix and the subsequent amplification and detection steps are performed in one single, sealed reaction vial without removing the matrix. | 2011-03-24 |
20110070586 | Multiplex Detection Of Agricultural Pathogens - Described are kits and methods useful for detection of agricultural pathogens in a sample. Genomic sequence information from agricultural pathogens was analyzed to identify signature sequences, e.g., polynucleotide sequences useful for confirming the presence or absence of a pathogen in a sample. Primer and probe sets were designed and optimized for use in a PCR based, multiplexed Luminex assay and/or an array assay to successfully identify the presence or absence of pathogens in a sample. | 2011-03-24 |
20110070587 | System For Genetic Surveillance and Analysis - A genetic surveillance system comprises a communications network and at least one reader-analyzer instrument. The reader-analyzer instrument has a communication interface to communicate over the network. The reader-analyzer instrument is adapted to perform genetic assay analysis of a sample obtained from a member of a population and to generate detection-related data based upon the analysis. The reader-analyzer instrument is adapted to associate qualifying information with the detection-related data and to communicate the associated qualifying information and detection-related data over the network. | 2011-03-24 |
20110070588 | Methods for Identifying Genomic Deletions - The genomic locus responsible for Van Buchem's disease is narrowed to an approximately 92 kb region of human chromosome 17 at 17q21. Individuals afflicted with or carriers of Van Buchem's disease exhibit a 52 kb deletion within this 92 kb region. Methods are provided that permit the differentiation between individuals homozygous for and therefore afflicted with Van Buchem's disease, individuals heterozygous for and therefore carriers of Van Buchem's disease, and individuals who are normal with respect to Van Buchem's disease. Also provided are general methodologies for the detection of a wide variety of large genomic deletions. | 2011-03-24 |
20110070589 | MAGNETIC LYSIS METHOD AND DEVICE - A method for lysing cells is disclosed. The method includes stirring cells with a magnetic stir element in the presence of a plurality of cell lysis beads at a speed sufficient to lyse the cells. Also disclosed is a device for lysing cells. The device includes a container having a magnetic stir element and a plurality of cell lysis beads disposed therein. The container is dimensioned to allow rotation of the magnetic stir element inside the container. | 2011-03-24 |
20110070590 | Primers and Methods for Determining RhD Zygosity - Provided herein are primers comprising a nucleotide sequence complementary to a portion of a RhD gene. Also provided herein are methods of determining a RhD zygosity in a subject. Also provided are methods of detecting a weak D allele in a subject. Further provided are kits for determining an RhD zygosity. | 2011-03-24 |
20110070591 | REPLICATION PROTEIN - This invention relates to a screening method for the identification of agents which modulate the activity of a DNA replication protein as a target for intervention in cancer therapy and includes agents which modulate said activity. The invention also relates to the use of the DNA replication protein, and its RNA transcripts in the prognosis and diagnosis of proliferative disease e.g., cancer. | 2011-03-24 |
20110070592 | DETECTION OF ANTIBODY THAT BINDS TO WATER SOLUBLE POLYMER-MODIFIED POLYPEPTIDES - The present invention provides analytical methods for detecting anti-polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble polymer-modified carrier and detecting binding of antibody to the water soluble polymer on the water soluble polymer-modified carrier wherein binding is indicative of the presence of antibody to the water polymer-modified polypeptide. Antibody may be detected to water soluble polymers such as polyethylene glycol, polysialic acid, dextran, hydroxyalkyl starch, or hydroxyethyl starch. When antibody to the water soluble polymer polyethylene glycol is to be detected, the carrier is modified with a non-linear polyethylene glycol derivative. | 2011-03-24 |
20110070593 | Conjugates of biological substances - Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens. | 2011-03-24 |
20110070594 | Method for Detecting Escherichia coli - Described herein are methods of detecting an infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample. | 2011-03-24 |
20110070595 | METHODS FOR THE IDENTIFICATION OF PARP INTERACTING MOLECULES AND FOR PURIFICATION OF PARP PROTEINS - The present invention relates to immobilization compounds and methods useful for the identification of PARP interacting compounds or for the purification or identification of PARP proteins. | 2011-03-24 |
20110070596 | AGENTS AND METHODS FOR ANALYZING PROTEIN INTERACTIONS - Agents and methods for qualitative and quantitative analysis a protein complex or protein complexes using isotope-labeled symmetrical bifunctional crosslinkers and mass spectrometry are provided. Targeting moieties, cell permeability moieties, or affinity moieties, may be appended to the bifunctional crosslinkers. The isotope-labeled symmetrical bifunctional crosslinkers may be used in a kit or as a library. | 2011-03-24 |
20110070597 | Thin-Film Passive Samplers for Detection of Hydrophobic Organic Contaminants and Estrogenicity in Various Environments - A thin-film passive sampler for use in detecting hydrophobic organic contaminants in air or aqueous environments. The sampler features a relatively thin layer of a suitable absorbent matrix coated directly on a solid support unit made of an inert material such as titanium or glass fibers. The passive samplers are simple and cost-effective to manufacture, easy to use, and exhibit rapid equilibration times and high accuracy. | 2011-03-24 |
20110070598 | DETECTION OF ELEVATED LEVELS OF HER-2/NEU PROTEIN ON CIRCULATING CANCER CELLS AND TREATMENT - The expression of Her-2/neu protein on circulating cancer cells in a blood sample is detected by isolating the cancer cells from the blood sample and then performing on the isolated cancer cells a sensitive Her-2/neu immunoassay. A positive result indicates the expression of Her-2/neu on cancer cells in the blood sample. This method can be used to identify cancer patients who are likely to benefit from treatment with an anticancer agent that targets Her-2/neu, such as trastuzumab (HERCEPTIN). | 2011-03-24 |
20110070599 | Method for Screening of Active Tuberculosis - The present invention provides an improved and simplified assay for use in diagnosing active Tuberculosis infections. The present assay is carried out using a sample of whole blood, does not require separating the blood into components, such as the isolation of peripheral blood mononucleocytes (PBMC), and is carried out using only cell-surface staining of T-cells. | 2011-03-24 |
20110070600 | PARTICLE AGGLUTINATION IN A TIP - An apparatus and a related method for performing particle agglutination reactions in at least one disposable probe tip are disclosed. The at least one probe tip includes a sample cavity for sample acquisition, at least one flanking cavity for the capture of particles by centrifugation or other means, a transition zone for the mixing of the sample with reagents for agglutination and a detection zone for the optical detection of particle agglutination. A mechanism may be attached to the probe tip for the controlled movement of fluids through the internal volume of the probe tip. The probe tip is particularly useful for the automation of high-throughput agglutination-type assays. | 2011-03-24 |
20110070601 | CLASSIFICATION OF INDIVIDUALS SUFFERING FROM CARDIOVASCULAR DISEASES ACCORDING TO SURVIVAL PROGNOSES AS FOUND BY MEASURING THE LEVELS OF BIOMARKER YKL-40 - The present invention relates to the method of measuring the YKL-40 level and using this measurement as a prognosis for survival of an individual suffering from heart disease caused by atherosclerosis. The method may be used for classification of individuals in order to optimize treatment or monitoring the individuals during the course of or prior to or after treatment. The individual may suffer from any type of cardiovascular disease or disorder. The method also detects and determines whether diagnostically or prognostically significant levels of YKL-40 molecules are present in a biological sample. Furthermore the level of YKL-40 may be used to predict disease relapse. | 2011-03-24 |
20110070602 | Methods and Apparatuses for Measuring Biological Processes Using Mid-Infrared Spectroscopy - This invention relates to methods and apparatuses for measuring biological processes using mid-infrared spectroscopy. The method includes the step of directing a mid-infrared signal into a sample of a biological process during a biologically active phase, and the step of detecting a sample spectrum from the mid-infrared signal to form a sample spectrum. The method includes the step of generating a reference spectrum through a reference media, and the step of combining the sample spectrum and the reference spectrum to form an adjusted sample spectrum. | 2011-03-24 |
20110070603 | DISC FOR TESTING BLOOD, BLOOD TESTER HAVING THE SAME, AND CONTROL METHOD THEREOF - Disclosed are a blood tester for measurement of temperature of a sample placed in a blood-testing disc using a thermochromic pigment, and a control method thereof. The disclosed blood-testing disc, the blood tester having the blood-testing disc loaded therein, and the control method of the same, are used to measure a light absorbance of the thermochromic pigment in order to determine a temperature of a sample when a biological material such as blood, blood serum, blood plasma, or sputum, is subjected to analysis, so that the test may be executed at a constant temperature. Accordingly, more reproducible and accurate results are obtainable, and temperature measurement of a sample may be simply and effectively attained by an optical analyzer built in the blood tester, without an alternative instrument or sensor for measurement thereof. | 2011-03-24 |
20110070604 | ANALYSIS OF EX VIVO CELLS FOR DISEASE STATE DETECTION AND THERAPEUTIC AGENT SELECTION AND MONITORING - Described herein is the analysis of nanomechanical characteristics of cells. In particular, changes in certain local nanomechanical characteristics of ex vivo human cells can correlate with presence of a human disease, such as cancer, as well as a particular stage of progression of the disease. Also, for human patients that are administered with a therapeutic agent, changes in local nanomechanical characteristics of ex vivo cells collected from the patients can correlate with effectiveness of the therapeutic agent in terms of impeding or reversing progression of the disease. By exploiting this correlation, systems and related methods can be advantageously implemented for disease state detection and therapeutic agent selection and monitoring. | 2011-03-24 |
20110070605 | REVERSIBLE MHC MULTIMER STAINING FOR FUNCTIONAL PURIFICATION OF ANTIGEN-SPECIFIC T CELLS - The present invention relates to a new method for reversible staining and functional isolation or characterization of cells, e.g. antigen-specific T cells. With this technique, the original functional status of cells can be substantially maintained after their identification and purification. Thus, this new method is of broad benefit for basic research and clinical applications. | 2011-03-24 |
20110070606 | SYSTEMS AND METHODS FOR ANALYZING BODY FLUIDS - Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device. | 2011-03-24 |
20110070607 | GLYCOPROTEIN SYNTHESIS AND REMODELING BY ENZYMATIC TRANSGLYCOSYLATION - A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an activated oligosaccharide moiety, in the presence of a catalyst comprising endoglycosidase (ENGase), to transfer the oligosaccharide moiety to the acceptor and yield the homogeneous glycoprotein or glycopeptide. The donor substrate includes, in a specific implementation, a synthetic oligosaccharide oxazoline. A related method of glycoprotein or glycopeptide remodeling with a predetermined natural N-glycan or a tailor-made oligosaccharide moiety, and a method of remodeling an antibody including a heterogeneous sugar chain, are also described. The disclosed methodology enables glycoprotein drugs to be modified for prolonged half-life in vivo, reduced immunogenicity, and enhanced in vivo activity, and for targeting and drug delivery. | 2011-03-24 |
20110070608 | Method for Producing Corn Gluten Hydrolysate and Corn Gluten Hydrolysate Using the Same - Provided is a method for producing corn gluten hydrolysate comprising: (a) separating corn gluten protein by removing carbohydrate, water soluble sugars, inorganic materials and fiber material; (b) preparing corn gluten protein lysate by carrying out acid hydrolysis, enzymatic hydrolysis or natural fermentation; and (c) increasing a content of branch chain amino acid (BCAA) which is included in the hydrolysate by isolating, concentrating, precipitating, desalting and filtering the resultant corn gluten protein lysate. With improved pre-treatment and concentration processes as compared with the conventional method, the hydrolysate prepared according to the present invention is rich in amino acids and low-molecular-weight peptides. In particular, free amino acids and branched-chain amino acids (BCAA) are included in large quantity. | 2011-03-24 |
20110070609 | Production of Foreign Nucleic Acids and Polypeptides in Sprout Systems - The present invention provides systems and methods for producing a nucleic acid or protein in transgenic sprouted seedlings or sprouted seedlings engineered to transiently express a nucleic acid or protein of interest. The sprouted seedlings of the invention are grown in a contained, regulatable environment, wherein expression of a pharmaceutically active protein is controlled by an exogenously inducible promoter or a viral promoter. The sprouted seedlings may be eaten live or preferably harvested live to preserve the maximal biological activity of the nucleic acid or protein. | 2011-03-24 |
20110070610 | Processing Enzymes Fused to Basic Protein Tags - The invention is related to processing enzyme comprising an N-terminally attached tag derived from highly basic proteins from thermophilic bacteria. The processing enzymes are useful for modifying proteins. They can be produced in high yields and can be effectively separated from the modified protein after use. | 2011-03-24 |
20110070611 | PROCESS FOR PREPARING HUMAN G-CSF - The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase. | 2011-03-24 |
20110070612 | GENE INACTIVATED MUTANTS WITH ALTERED PROTEIN PRODUCTION - A recombinant filamentous fungal cell (e.g. | 2011-03-24 |
20110070613 | Monoclonal Antibody - The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD). | 2011-03-24 |
20110070614 | FUCOSE TRANSPORTER - The present invention provides a gene encoding a fucose transporter, a fucose transporter polypeptide, a method for screening for a compound that binds to a fucose transporter or a compound that inhibits fucose transport activity, a cell having inhibited fucose transporter functions, and a cell wherein the expression of the fucose transporter is inhibited. The present invention further relates to a method for producing recombinant protein, and specifically, to a method for producing protein by which fucose existing within the Golgi apparatus of a host cell is decreased, a method for inhibiting the addition of fucose to protein by which fucose existing within the Golgi apparatus of a host cell is decreased upon production of recombinant protein using the host cell, a method for increasing the cytotoxic activity of an antibody by which an antibody is produced using a cell wherein fucose existing within the Golgi apparatus is decreased, and a cell having a Golgi apparatus wherein fucose existing within the Golgi apparatus is decreased. | 2011-03-24 |
20110070615 | Compositions and Methods Relating to Anti-IGF-1 Receptor Antibodies - The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric anti-IGF-1R antibodies that bind human IGF-1R, IGF-1R-binding fragments and derivatives of such antibodies, and IGF-1R-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having IGF-1R-related disorders or conditions. | 2011-03-24 |
20110070616 | PRODUCTION OF ITACONIC ACID - The invention relates to a nucleic acid sequence encoding an itaconate transporting Major Facilitator Superfamily Transporter (MFST) gene sequence and the protein encoded thereby. Preferably said sequence is the nucleic acid that comprises the sequence of ATEG_09972.1 of | 2011-03-24 |
20110070617 | Liquid methanol fuel production from methane gas at bio-normal temperatures and presure - Through staged and monitored control of gas, liquid, and solid source materials, the highly-efficient enzymatic ‘natural factory’ of specific methanotropic bacteria, which evolved dual, alternative, metabolic channels, can be manipulated for human goals. The first stage sets these bacteria to producing liquid methanol by oxidation of methane gas under aerobic conditions (their high-energy channel), which is harvested at the peak. The second stage, by establishing anaerobic conditions and providing supplementary metals, forces the bacteria to use their lower-energy channel for inorganic hydrogen-donor to organic-energy-transport, during which the older and weaker organisms become ‘food’ for newer and (relatively) stronger organisms. This accomplishes the desired result of liquid methanol production without employing a human-engineered industrial-chemical process with the costly high energy requirements associated with temperatures and pressures required by the prior art for converting methane gas to liquid methanol. | 2011-03-24 |
20110070618 | METHOD FOR PRODUCING ETHANOL USING RAW STARCH - Disclosed are methods for producing high levels of alcohol during fermentation of plant material, and to the high alcohol beer produced. | 2011-03-24 |
20110070619 | FERMENTATION OF A LIGNOCELLULOSE-CONTAINING MATERIAL - The invention relates to a process of fermenting a hydrolysed pre-treated lignocellulose-containing material to produce a fermentation product. | 2011-03-24 |
20110070620 | SUBSTRATES COMPRISING SWITCHABLE FERROMAGNETIC NANOPARTICLES - In a process for producing organic substrate particles bonded to switchable ferromagnetic nanoparticles with a mean particle diameter in the range from 10 to 1000 nm, the ferromagnetic nanoparticles used are those nanoparticles which are nonferromagnetic at first, but become ferromagnetic when the temperature is lowered, these at first nonferromagnetic nanoparticles in dispersed form are bonded to the organic substance particles, and then the nanoparticles bonded to the substrate particles are made ferromagnetic as a result of the temperature being lowered. | 2011-03-24 |
20110070621 | Multivalent Clostridial Toxins - The present invention is directed to multivalent Clostridial toxin comprising more than one binding domain directed to a cell surface molecule of a target cell. Such modified toxins are useful as therapeutic compositions to prevent exocytosis and secretion by the target cell. Conditions in which such compositions may be useful include, without limitation, disorders of the sensory or motor nervous system, acute or chronic pain, cancer, pancreatitis, hyperhydrosis, glandular disorders, viral infections, cystic fibrosis and the like. The invention is also directed to methods of using and administering such a composition, and methods of treating a given condition using such a composition. | 2011-03-24 |
20110070622 | PURIFICATION OF COLLAGENASES FROM CLOSTRIDIUM HISTOLYTICUM LIQUID CULTURE - The present invention provides a method for purifying | 2011-03-24 |
20110070623 | SELF-INACTIVATING HELPER ADENOVIRUSES FOR THE PRODUCTION OF HIGH-CAPACTIY RECOMBINANT ADENOVIRUSES - The invention relates to reagents and methods for the generation of auto-inactivating helper adenoviruses that allow the development of cell systems for the generation of high-capacity recombinant adenovirus showing a reduced contamination by auxiliary adenoviruses. | 2011-03-24 |
20110070624 | MICROWAVE RESONANT ABSORPTION METHOD AND DEVICE FOR VIRUSES INACTIVATION - Virus inactivation is performed with a specific microwave frequency to induce a collective vibration of virus through microwave resonant absorption (MRA). | 2011-03-24 |
20110070625 | NOVEL FLUORESCENT PROTEINS AND METHODS FOR USING SAME - The present invention provides nucleic acid molecules encoding novel red fluorescent proteins from | 2011-03-24 |
20110070626 | Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics - The invention provides isolated polypeptide and nucleic acid sequences derived from | 2011-03-24 |
20110070627 | Composition for the cultivation of sophisticated bacteria - The present invention relates to a composition for the cultivation of sophisticated bacteria, preferably of the genus | 2011-03-24 |
20110070628 | BIOMASS PROCESSIGN - A biomass processing system is disclosed, with an algae biomass growth container and a pyrolysis reactor for pyrolysis processing of the algae biomass. A conveying apparatus links the pyrolysis reactor and the biomass growth container for conveying at least part of at least one of the pyrolysis products from the reactor to the biomass growth container for promoting algae biomass growth. The pyrolysis product is a nutrient-rich aqueous phase produced directly or indirectly through pyrolysis processing to the biomass growth container, e.g. an aqueous phase derived from the vapour products of the pyrolysis, or a char wash obtained by washing the char product of the pyrolysis. | 2011-03-24 |
20110070629 | METHOD FOR MICROPROPAGATION OF MONOCOTS BASED ON SUSTAINED TOTIPOTENT CELL CULTURES - The present invention provides a method of micropropagating a monocotyledonous plant comprising: (a) cultivating an explant of tissue from a monocotyledonous plant shoot tip on a primary medium, wherein the explant has been pretreated with a cold temperature and the primary medium comprises auxin or auxin and cytokinin, to produce a totipotent embryogenic cell culture; (b) treating the totipotent embryonic cell culture with a cold temperature; (c) maintaining the totipotent embryogenic cell culture by cultivation on a secondary medium, whereby a totipotent embryogenic cell culture of a monocotyledonous plant is produced and maintained; and (d) transferring the embryogenic cell culture of step (c) to a tertiary medium to continue multiplication and to produce a plantlet with roots and shoots, thereby micropropagating a monocotyledonous plant. The micropropagation techniques described herein provide plants for such purposes as development of elite plant lines, phytoremediation and biomass production. | 2011-03-24 |
20110070630 | METHOD FOR DERACEMIZATION OF ENANTIOMER MIXTURES - The invention relates to a process for enzymatic deracemization of enantiomer mixtures of secondary alcohols by a combination of oxidation and reduction reactions by means of stereoselective alcohol dehydrogenases and the cofactors thereof, wherein one enantiomer of an optically active secondary alcohol is in a formal sense selectively oxidized to the corresponding ketone, which is subsequently reduced selectively to the optical antipode, while the reduced form of the cofactor is provided for the reduction reaction by means of an additional enzyme, characterized in that two alcohol dehydrogenases with opposite stereoselectivity and different cofactor selectivity and the two corresponding, different cofactors are used for the oxidation and reduction reactions, and the oxidized and reduced cofactors are interconverted in a parallel enzymatic reaction with the additional enzyme, the direction of the deracemization toward one of the two enantiomers being controllable by the selection of the two alcohol dehydrogenases or using the selectivity difference of the additional enzyme for the two cofactors. | 2011-03-24 |
20110070631 | Container transportation case and culture treating device - A container transportation case is used to carry in/out a culture container to/from a chamber of a culture treating device. A case body of the container transportation case has a container housing room in which the culture container can be arranged and the container housing room is in communication with the outside by an opening part. A joint unit of the container transportation case can be attached/removed to/from a carrying-in/out opening of the culture treating device, and forms a space that is isolated from an outside atmosphere by joining the container housing room and the carrying-in/out opening. An airtight member of the container transportation case closes the opening part to block the container housing room from the outside atmosphere. | 2011-03-24 |
20110070632 | Photo bioreactor and cultivation system for improved productivity of photoautotrophic cell cultures - This invention relates to open or close top photobioreactor apparatus for improved productivity with a small footprint, that can be placed in varied temperature zones, above or below ground on land or in water or use in space-station for conducting aqueous aerobic or anaerobic; continues or batch wise cultivation and harvesting of photoautotrophic organism's. | 2011-03-24 |
20110070633 | ANALYTICAL TOOL, ANALYTICAL TOOL PACK, CARTRIDGE INCLUDING PLURALITY OF PACKS, METHOD OF MAKING ANALYTICAL TOOL PACK, ANALYZER, AND MECHANISM FOR TAKING OUT OBJECT - The present invention relates to an analytical tool pack ( | 2011-03-24 |
20110070634 | BIOSENSOR - An inexpensive biosensor is provided that can realize an electrochemical analysis and perform measurement with high accuracy or convenience. The biosensor is an immunological sensor that enables measurement anywhere at anytime by anyone while keeping convenience. The biosensor includes: an electrode sensor unit | 2011-03-24 |
20110070635 | SYSTEMS AND METHODS OF GENERATING ENERGY AND FRESH WATER FROM SOLAR RADIATION - A combined solar reflector and desalination assembly is provided for generating energy and fresh water from solar radiation. The solar reflector assembly is configured to be deployed on a supporting body of liquid and to reflect solar radiation to a solar collector. A combined solar reflector and desalination assembly comprises an inflatable elongated tube having an upper portion formed at least partially of flexible material and a lower ballast portion formed at least partially of flexible material. A reflective sheet is coupled to a wall of the tube to reflect solar radiation. At least one catchment device and collection assembly are coupled to the tube. The elongated tube may have an axis of rotation oriented generally parallel to a surface of a supporting body of liquid. | 2011-03-24 |
20110070636 | RESILIENT MEMBER AND DEVICE, IN PARTICULAR A BIO FILM REACTOR - The present invention relates to a resilient member (FIG. | 2011-03-24 |
20110070637 | Thermal cycler - A thermal cycler includes a bearing element, a heating element, a first cooling element, and a temperature controller. The bearing element carries at least one reaction mixture. The heating element raises the temperature of the reaction mixture. The heating element includes a housing, at least one carbon nanotube structure and a pair of electrodes. The carbon nanotube structure and the pair of electrodes are accommodated in the housing. The pair of electrodes is electrically connected to the carbon nanotube structure. The first cooling element cools the temperature of the reaction mixture. The temperature controller is electrically connected to the heating element and the first cooling element. The temperature controller controls the operation of the heating element and the first cooling element | 2011-03-24 |
20110070638 | APPARATUS AND METHOD FOR PREPARATIVE SCALE PURIFICATION OF NUCLEIC ACIDS - Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using flotation to separate and eliminate undesired insoluble cellular debris including chromosomal DNA from the lysates. A gas is introduced to controllably generate bubbles that reduce the density of the cell debris and create a buoyant flocculent phase that can be readily separated from, and thus provide, a substantially clarified fluid lysate phase that is enriched in extrachromosomal DNA but substantially depleted of cellular proteins and chromosomal DNA. | 2011-03-24 |
20110070639 | METHOD OF DESIGNING HYDRODYNAMIC CAVITATION REACTORS FOR PROCESS INTENSIFICATION - The present invention describes an apparatus of Hydrodynamic cavitation, to be used as reactors to achieve tangible effect by producing tailored active cavities either transient or steady or both, in aqueous and non-aqueous media for intensification of the physical and chemical processes in homogenous and heterogeneous systems. An apparatus comprises of a cavity generator, cavity diverter and turbulence manipulator wherein the cavity generator/cavity diverter is a flow modulator of various shapes and sizes. A regime map of cavitation and a method to generate it, is presented to achieve the desired type of cavitation, required for specific targeted process intensification and then reactors are designed to achieve the predetermined process intensification. Regime map relates the maximum fluid velocity in cavity generator with the cavitation number, active and specific type of cavity fraction for several geometric designs of apparatus. | 2011-03-24 |
20110070640 | OPTIMIZED HIGH YIELD SYNTHETIC PLASMIDS - One aspect of the current invention is an optimized synthetic mammalian expression plasmid with a mutated origin of replication (e.g. “mut” family of plasmids) comprising a therapeutic element, and a replication element. The therapeutic elements of this plasmid are operatively linked and located in a first operatively-linked arrangement. Additionally, the optimized synthetic mammalian expression plasmid comprises replication elements, wherein the replication elements are operatively linked and located in a second operatively-linked arrangement. The first-operatively-linked arrangement and the second-operatively-linked arrangement comprise a circular structure of the codon optimized synthetic mammalian expression plasmid. | 2011-03-24 |
20110070641 | Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations - Enriched pancreatic stem and progenitor cell populations, and methods for identifying, isolating, and enriching for pancreatic stem cells using reagents that bind to cell surface markers are provided. | 2011-03-24 |
20110070642 | DEVICE AND METHOD FOR ISOLATING AND CULTIVATING LIVE CELLS ON A FILTER OR EXTRACTING THE GENETIC MATERIAL THEREOF - A device for isolating and cultivating live cells on a filter or for extracting the genetic material thereof includes: a filter holder ( | 2011-03-24 |
20110070643 | Utilization of Pharmacological Chaperones to Improve Manufacturing and Purification of Biologics - The present invention provides methods for improving the production of recombinant proteins through the use of pharmacological chaperones for the recombinant proteins. As exemplified by the present invention, the binding of a pharmacological chaperone to a recombinant protein expressed by a cell can stabilize the protein and increase export of the protein out of the cell's endoplasmic reticulum, and increase secretion of the protein by the cell. | 2011-03-24 |
20110070644 | Monocyte-Derived Stem Cells (MDSC) and Methods of Use Thereof - Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals is provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease. | 2011-03-24 |
20110070645 | COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS - Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described. | 2011-03-24 |
20110070646 | Biomimetic Cell Scaffolds - This invention relates to biomimetic implants containing mammalian cells which are induced by their environment to produce gradients of diffusible factors. This may be useful in eliciting a physiological pro-angiogenic response which stimulates angiogenesis and revascularisation in tissue adjacent the implant, for example in therapeutic applications in which increased angiogenesis and/or vasculogenesis is required. This may also be useful in providing biomimetic mammalian cell niches for cell culture and differentiation. | 2011-03-24 |
20110070647 | PLURIPOTENT STEM CELL THAT CAN BE ISOLATED FROM BODY TISSUE - Objects of the present invention are to provide a method for directly obtaining pluripotent stem cells from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stem cells that can be isolated from body tissue. | 2011-03-24 |
20110070648 | METHOD FOR CELL EXPANSION - The present invention relates to a method for cell expansion. More closely, it relates to a method for expansion of cells, such as mesenchymal stem cells, on microcarriers in a plastic bag bioreactor. The invention enables expansion to therapeutic amounts of stem cells. The method comprises the following steps: a) addition of cells in cell culture medium and microcarriers to a plastic bag container; b) allowing the cells to adhere to the microcarriers while the container is kept substantially still; c) addition of further cell culture medium once the cells have adhered; d) culturing the cells under gentle and constant agitation; e) increase the surface area for continued culturing; and f) final harvesting of cells by an active detachment and separation step. | 2011-03-24 |
20110070649 | METHOD FOR MANUFACTURING GLYCOPROTEINS HAVING HUMAN-TYPE GLYCOSYLATION - The present invention provides a method for manufacturing a glycoprotein having a human-type sugar chain comprising a step in which transformed plant cell is obtained by introducing to a plant cell the gene of glycosyltransfetase and the gene of an exogenous glycoprotein, and a step in which the obtained transformed plant cell is cultivated. | 2011-03-24 |
20110070650 | Method of Enhancing Homologous Recombination of Somatic Cells and Method of Acquiring Specific Antibody - The present invention provides a novel method for obtaining diverse antibodies as a result of markedly enhancing the somatic homologous recombination at an antibody locus in immunocytes. | 2011-03-24 |
20110070651 | RECOMBINANT VIRAL VECTOR FOR GENE TRANSFER INTO LYMPHOID CELLS - A recombinant herpesvirus, a method for producing the recombinant herpesvirus, and a pharmaceutical composition comprising the recombinant herpesvirus, are provided with a method for producing a recombinant herpesvirus using a BAC vector sequence. In addition, a vector comprising a herpesvirus genomic gene and a BAC vector sequence, a cell comprising the vector, and a nucleic acid cassette comprising a fragment, which is capable of homologous recombination with a herpesvirus genome, and a BAC vector sequence, are provided. | 2011-03-24 |
20110070652 | PHAGE MICROARRAY PROFILING OF THE HUMORAL RESPONSE TO DISEASE - The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides methods and compositions for phage microarray profiling of cancer (e.g., prostate, lung, or breast cancer). The present invention further provides novel markers useful for the diagnosis, characterization, and treatment of cancers. | 2011-03-24 |
20110070653 | INHIBITOR OF HISTONE ACETYLTRANSFERASE, ESPECIALLY p300 - An inhibitor of histone acetyltransferase p300 was isolated from human cDNA library and identified as a nuclear protein composed of 855 amino acid residues. It binds to the cysteine/histidine-rich region of p300, thereby inhibiting the transcriptional activation by p300. It also inhibits the transcription activity of p53, with p300 functioning as a coactivator, and inhibits the discontinuance of cell cycle that relies on p53. | 2011-03-24 |
20110070654 | VALVE ANALYTICAL SYSTEM - A lab on a valve analytical system includes a rotary sample preparation assembly having a stator and a rotor. The rotor includes a plurality of integral syringe pumps which can be aligned with passages formed within the stator. The stator passages can be connected with fluid inlet connector which connect the sample preparation assembly with fluid sources, and fluid outlet connectors which connect the sample preparation assembly with one or more wet chemical analytical devices. Some embodiments can include a mixer and optical sensor connected with the fluid outlets. One or more drive motors can be used to control simultaneous actuation of one or more of the syringe pumps, thereby providing for simultaneous delivery of metered volumes of fluid. | 2011-03-24 |
20110070655 | FLOW CELL AND LIQUID DELIVERY METHOD - A flow cell includes: a flow channel through which a sample solution flows; an inlet section which communicates with the flow channel and to which the sample solution is supplied; a transfer section which includes a plurality of opening sections, one end side of which communicates with the flow channel and an other side of which opens to outside air, and which communicates with the flow channel, and draws in and guides the sample solution supplied into the inlet section to the flow channel; a detecting section which faces the sample solution in the flow channel; and a sealing member which unsealably seals at least either one of the opening section or the inlet section. | 2011-03-24 |
20110070656 | Fluorescent Proteins - A fluorescent protein (bFP) having chemiluminescence activity is a complex composed of the apoprotein of a calcium-binding photoprotein, coelenteramid or an analog thereof, and calcium ions or divalent or trivalent ions that can be substituted for the calcium ions. In the complex, the ratio of the number of molecules of the apoprotein to that of the coelenteramid is 1:1 and the ratio of the number of molecules of the apoprotein to that of the divalent or trivalent ions is 1:1 to 1:4. The fluorescent protein is used as a marker because it catalyzes luminescence of coelenterazine and has fluorescence capability. Removal of calcium ions etc. from this fluorescent protein (bFP) having luminescence activity provides a novel fluorescent protein (gFP). Mixing this gFP with the coelenterazine provides a calcium-binding photoprotein, which emit light instantaneously, enabling use as a marker. | 2011-03-24 |
20110070657 | DETECTING IONS AND MEASURING ION CONCENTRATIONS - The present inventions include methods and compositions for detecting the presence of ions and measuring the level or concentration of ions in a sample by nuclear magnetic resonance (NMR) using magnetic particles. In particular, the inventions include the preparation and use of magnetic particles having synthetic ion chelators covalently bound to their surfaces. In the presence of target ions, the surface-modified magnetic particles form clusters, which can be monitored by NMR relaxation measurements. The relaxation times can then be used to detect specific ions and determine their concentration. The described methods, compositions, and devices are useful for a variety of applications including biomedical applications in diagnostics and imaging. | 2011-03-24 |
20110070658 | SYSTEMS AND METHODS FOR DETERMINING THE PERCENTAGE OF GLYCATED HEMOGLOBIN - Described herein are systems and methods for assaying a sample to quantitatively determine the percentage of glycated hemoglobin in the sample. | 2011-03-24 |
20110070659 | SAMPLE PRESENTATION DEVICE - The present invention relates to sample presentation devices useful in performing analytical measurements. These devices have been configured to enable various aspects of liquid handling such as: retention, storage, transport, concentration, positioning, and transfer. Additionally, these devices can enhance the detection and characterization of analytes. The sample presentation devices of the present invention are comprised of one or more substrates having a plurality of zones of differing wettability. Methods of analyzing samples using the sample presentation device of the invention, as well as methods of making the sample presentation devices are disclosed. | 2011-03-24 |
20110070660 | DETECTION OF POLYMERIC ANALYTES - The present invention relates to methods for detecting polymeric analytes, especially biopolymers, and sensors for detecting the polymeric analytes. The present invention uses magnetic beads in a rotating magnetic field to provide a visual detection of the presence of a polymeric analyte, such as nucleic acids, lipids, polysaccharides, proteins, etc. When a polymeric analyte binds to the magnetic beads, application of a rotating magnetic field to the beads results in unique pinwheel formations. Without the presence of the polymeric analyte, the movement of the magnetic beads induced by the rotating magnetic field differs significantly from the pinwheel formations. The pinwheel, therefore, is used to detect the presence of polymeric analytes. | 2011-03-24 |
20110070661 | RAMAN-ACTIVE REAGENTS AND THE USE THEREOF - The present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Raman-active reporter molecule, a binding molecule, and a surface enhancing particle capable of causing surface enhanced Raman scattering (SERS). The Raman-active reporter molecule and the binding molecule are affixed to the particle to give both a strong SERS signal and to provide biological functionality, i.e. antigen or drug recognition. The Raman-active reagents can function as an alternative to fluorescence-labeled reagents, with advantages in detection including signal stability, sensitivity, and the ability to simultaneously detect several biological materials. The Raman-active reagents also have a wide range of applications, especially in clinical fields (e.g., immunoassays, imaging, and drug screening). | 2011-03-24 |
20110070662 | RAMAN-ACTIVE REAGENTS AND THE USE THEREOF - The present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Raman-active reporter molecule, a binding molecule, and a surface enhancing particle capable of causing surface enhanced Raman scattering (SERS). The Raman-active reporter molecule and the binding molecule are affixed to the particle to give both a strong SERS signal and to provide biological functionality, i.e. antigen or drug recognition. The Raman-active reagents can function as an alternative to fluorescence-labeled reagents, with advantages in detection including signal stability, sensitivity, and the ability to simultaneously detect several biological materials. The Raman-active reagents also have a wide range of applications, especially in clinical fields (e.g., immunoassays, imaging, and drug screening). | 2011-03-24 |
20110070663 | Method for the enrichment of phosphorylated and/or glycosylated analytes - The present invention relates to a method for the purification and isolation of phosphorylated and glycosylated analytes using titanium dioxide particles. | 2011-03-24 |
20110070664 | Integrated Microfluidic Device for Serum Biomarker Quantitation using Either Standard Addition or a Calibration Curve - Apparatus and method for determining concentration of one or more target compounds in a sample solution containing one or more nontarget compounds that uses an affinity column to immobilize the target compounds. The target compounds are eluted and passed through a separation/detection system to determine quantitative measure of concentration for each of the target compound. | 2011-03-24 |
20110070665 | DC and RF Hybrid Processing System - The invention can provide apparatus and methods for processing substrates and/or wafers in real-time using at least one Direct Current (DC)/Radio Frequency (RF) Hybrid (DC/RFH) processing system and associated Direct Current/Radio Frequency Hybrid (DC/RFH) procedures and DC/RFH process parameters and/or DC/RFH models. | 2011-03-24 |