12th week of 2012 patent applcation highlights part 49 |
Patent application number | Title | Published |
20120071615 | Bi-Nuclear Metallocene Compound and the Preparation Method of Polyolefin Using the Same - The present invention relates to a binuclear metallocene compound having a new structure that is able to offer various selectivities and activities for copolymers, a preparation method thereof, and a method for preparing a polyolefin using the binuclear metallocene compound. | 2012-03-22 |
20120071616 | Pyridyldiamido Transition Metal Complexes, Production And Use Thereof - Pyridyldiamido transition metal complexes are disclosed for use in alkene polymerization. | 2012-03-22 |
20120071617 | DIKETOPYRROLOPYRROLE POLYMERS FOR USE IN ORGANIC SEMICONDUCTOR DEVICES - The present invention relates to polymers comprising one or more (repeating) unit(s) of the formula A polymer, comprising (repeating) unit(s) of the formula (1) and (2), wherein A is a repeating unit of the formula (I), and —COM | 2012-03-22 |
20120071618 | LIQUID CRYSTAL COMPOSITIONS - This invention relates to liquid crystal compositions, and polymer networks and articles comprising the compositions. The compositions comprise at least one compound of the group of compounds represented by the structures of each of the following Formulas (IV), (V) and (VI), | 2012-03-22 |
20120071619 | Method for Elastomer Finishing - In the production of isobutylene-based elastomers the product obtained from the polymerization process is often in the form of a stream. Described herein are an apparatus and a process for removal of hydrocarbon liquids from the elastomer. The process comprises the steps of obtaining a stream comprising hydrocarbon liquids, either solvents or diluents, and an isobutylene-based elastomer; passing the stream through a kneader to volatize the hydrocarbon liquids from the elastomer. | 2012-03-22 |
20120071620 | METHOD FOR CRYSTALLIZING (METH)ACRYLIC ACID AND METHOD FOR REGULATING CONTENT OF POLYMERIZATION INHIBITOR IN PRODUCT (METH)ACRYLIC ACID | 2012-03-22 |
20120071621 | METHOD AND DEVICE FOR PRODUCING A POLYMER TAPE - The invention relates to a method for producing a highly oriented, high molecular weight polymer tape. The method comprises: a) forming a non-fibrous polymeric sheet; ( | 2012-03-22 |
20120071622 | Method for Providing a Secondary or Tertiary Amine - A method for providing a secondary or tertiary amine with formula (R | 2012-03-22 |
20120071623 | POLYUREAS PREPARABLE FROM TWO POLYETHERAMINES AND A PREPOLYMER - The invention relates to a polyurea preparable from
| 2012-03-22 |
20120071624 | PROCESS FOR PREPARING 1,6-HEXANEDIOL - The invention provides 1,6-hexanediol having a proportion by weight of nitrogen of less than 5 ppm, and polymers obtained by reacting the 1,6-hexanediol with at least one reactive compound. The 1,6-hexanediol is obtained by distilling a mixture including 1,6-hexanediol and more than 500 ppm of at least one carboxylic acid, ester, or both, having a boiling point higher than that of the 1,6-hexanediol and being in contact with the 1,6-hexanediol at a temperature range greater than or equal to 100° C. for at least 5 minutes before, during, or before and during, the distillation, followed by collection of the 1,6-hexanediol. In certain embodiments of this invention, the 1,6-hexanediol has a proportion by weight of nitrogen of less than 3 ppm and less than 2 ppm. | 2012-03-22 |
20120071625 | PROCESS FOR MAKING POLYETHYLENE TEREPHTHALATE - The invention relates to a process for making polyethylene terephthalate (PET) from ethylene glycol (EG), purified terephthalic acid (PTA) and optionally up to 30 mol % comonomer, using a catalyst system essentially consisting of antimony—(Sb), zinc—(Zn) and phosphorous—(P) compounds, comprising the steps of a) esterifying EG and PTA to form diethyleneglycol terephthalate and oligomers (DGT), and b) melt-phase polycondensing DGT to form polyester and EG1 wherein the Sb- and P-compounds are added in step a) and the Zn-compound is added after step a). With this process PET can be obtained that shows favourable colour and optical clarity, also if recycling of EG is applied in the process, and a relatively low rate of acetaldehyde re-generation during melt-processing. | 2012-03-22 |
20120071626 | FLUORINATED AROMATIC BIS(ACYL)-CONTAINING COMPOUNDS AND POLYESTERS PREPARED THEREFROM - A fluorinated bis(acyl)-containing compound of Formula (I), where R | 2012-03-22 |
20120071627 | Soluble, Degradable Poly(ethylene glycol) Derivatives for Controllable Release of Bound Molecules into Solution - PEG and related polymer derivatives having weak, hydrolytically unstable linkages near the reactive end of the polymer are provided for conjugation to drugs, including proteins, enzymes, small molecules, and others. These derivatives provide a sufficient circulation period for a drug-PEG conjugate, followed by hydrolytic breakdown of the conjugate and release of the bound molecule. In some cases, drugs that demonstrate reduced activity when permanently coupled to PEG maintain a therapeutically suitable activity when coupled to a degradable PEG in accordance with the invention. The PEG derivatives of the invention can be used to impart improved water solubility, increased size, a slower rate of kidney clearance, and reduced immunogenicity to a conjugate formed by attachment thereto. Controlled hydrolytic release of the bound molecule into an aqueous environment can then enhance the drug's delivery profile by providing a delivery system which employs such polymers and utilizes the teachings provided herein. | 2012-03-22 |
20120071628 | TOPICAL THERAPEUTIC AGENT FOR OPHTHALMIC DISEASES COMPRISING COMPOUND CAPABLE OF BINDING SPECIFICALLY TO DNA SEQUENCE - Disclosed is a topical therapeutic agent for ophthalmic diseases, which comprises a compound capable of binding specifically to a DNA sequence. More preferably disclosed is a topical therapeutic agent for ophthalmic diseases, which comprise a pyrrole-imidazole polyamide having a specific structure. The topical therapeutic agent for ophthalmic diseases comprises a pyrrole-imidazole polyamide which can inhibit transforming growth factor-β gene and matrix metalloproteinase 9 gene. | 2012-03-22 |
20120071629 | APPOPTOSIN AND USES THEREOF FOR TREATING NEURODEGENERATIVE DISEASE AND CANCER - Disclosed herein are compositions and methods relating to the modulation of Appoptosin levels or activity in the treatment of Neurodegenerative disorders or cancer. | 2012-03-22 |
20120071630 | Nucleic Acid and Amino Acid Sequences of Infectious Salmon Anaemia Virus and Their Use as Vaccines - The present invention provides the use of nucleic acid sequences and/or amino acid sequences in the preparation of a vaccine for the protection of fish against infectious salmon anaemia virus. Specifically, such vaccines contain at least one nucleic acid sequence which is derived from ISAV or synthetically prepared analogues thereof, or substantially homologous sequences. These nucleic acid sequences are transcripted and translated into peptide sequences which are incorporated into a vaccination strategy to induce and immune response to the surface antigens of ISAV and therefore ISAV itself. Therefore both the use of a vaccine against ISAV, and the incorporation of peptide sequences is herein described. | 2012-03-22 |
20120071631 | Isolation and Characterization of Novel Green Fluorescent Proteins from Copepods - The isolation and characterization of two protein isoforms collected green fluorescent copepods is described herein. The new | 2012-03-22 |
20120071632 | Lenalidomide and Thalidomide Immunoassays - Novel conjugates and immunogens derived from lenalidomide and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of thalidomide and lenalidomide in biological fluids. | 2012-03-22 |
20120071633 | METHOD FOR PURIFICATION OF TARGET POLYPEPTIDES - The present invention relates to a process for purification of a target molecule, comprising the steps: (a) contacting a target molecule, and a population of target binding polypeptides (TBP), in solution for a sufficient time to allow complex formation; and (b) isolating the target from the complex from (a) by subsequent purification steps, wherein (i) the target binding polypeptides have at least two binding functionalities; a first binding functionality towards the target and a second binding functionality towards a catching ligand comprised in a solid support; and (ii) the first binding functionality comprises at least two binding sites for the target, and the target comprises at least two binding sites for the TBP. | 2012-03-22 |
20120071634 | Antibody Constant Region Variant - By altering amino acid sequences, the present inventors successfully produced constant regions that can confer antibodies with particularly favorable properties for pharmaceutical agents. When used to produce antibodies, the altered constant regions produced according to the present invention significantly reduce heterogeneity. Specifically, the antibody homogeneity can be achieved by using antibody heavy chain and light chain constant regions introduced with alterations provided by the present invention. More specifically, the alterations can prevent the loss of homogeneity of antibody molecules due to disulfide bond differences in the heavy chain. Furthermore, in a preferred embodiment, the present invention can improve antibody pharmacokinetics as well as prevent the loss of homogeneity due to C-terminal deletion in antibody constant region. | 2012-03-22 |
20120071635 | METHODS AND COMPOSITIONS FOR MODULATING TUMOR CELL ACTIVITY - Antibodies which target clusterin, a protein involved in the epithelial-to-mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumour cell activity through binding the clusterin. | 2012-03-22 |
20120071636 | RISPERIDONE IMMUNOASSAY - Novel conjugates and immunogens derived from risperidone and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of risperidone and paliperidone in biological fluids. | 2012-03-22 |
20120071637 | SELECTIVE ENRICHMENT OF ANTIBODIES - The invention relates to a process for the selective concentration of immunoglobulins or other proteins that contain an Fc domain (target protein), comprising the following steps:
| 2012-03-22 |
20120071638 | Copolymer for positive type lithography, polymerization initiator used in production of said copolymer, and composition for semiconductor lithography - A copolymer for positive type lithography, having at least a recurring unit (A) having a structure wherein an alkali-soluble group is protected by an acid-dissociating, dissolution-suppressing group, represented by the following formula (A) | 2012-03-22 |
20120071639 | Methods and compositions of nucleic acid ligands for detection of foodborne and waterborne pathogens - Specific DNA sequences for binding various foodborne and waterborne pathogens and biotoxins are described. Each of these sequences can function in varying assay and sensor formats with varying degrees of success. | 2012-03-22 |
20120071640 | Sulfurizing reagents and their use for oligonucleotides synthesis - An oligonucleotide which comprises at least one internucleotide linkage comprising a P—S—R bond and at least two nucleosides, wherein R corresponds to the formula (I) | 2012-03-22 |
20120071641 | NUCLEIC ACID CHEMICAL MODIFICATIONS - The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene. | 2012-03-22 |
20120071642 | COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF A CARBAPENEMASE GENE - Compositions and methods for the rapid and sensitive detection of a carbapenemase in a sample are provided. The compositions include novel primer and probe compositions for use in detecting the presence of this enzyme in a sample, particularly using PCR methods. These primers and probe sets can be used in amplification methods (such as PCR, particularly quantitative PCR) and packaged into kits for use in amplification methods for the purpose of detecting carbapenemase in a test sample, particularly a patient sample, particularly a direct sample. Thus, in one embodiment, the present invention provides for novel oligonucleotide primers set forth in SEQ ID NOs:1, 2, 4, 5, 7, 8, 14, 15, 17, 18, and 20, and the novel oligonucleotide probe sequences set forth in SEQ ID NOs:3, 6, 9, 16, and 19. These sequences can be used in a method of detecting carbapenemase in a sample. | 2012-03-22 |
20120071643 | SYSTEM AND METHODS FOR PURIFYING BIOLOGICAL MATERIALS - Fluid sample purification systems and methods are provided for isolating molecules of interest in a fluid sample. The fluid sample purification system has a housing with a distal end and distal opening adapted for the passage of a fluid and a proximal end and proximal opening adapted for passage of a fluid. A distal retainer is located inside the housing and above the distal opening. A proximal retainer is located inside the housing between the distal retainer and the proximal opening, or is located adjacent to, in contact with, or over the proximal opening. The system also comprises adsorption material, e.g., functionalized particles, inside the housing and confined between the distal retainer and the proximal retainer. The adsorption material adsorbs undesirable material while simultaneously rejecting desirable materials. Methods are also provided for isolating molecules of interest using the fluid sample purification system. | 2012-03-22 |
20120071644 | COMPOUNDS FOR FLUORESCENT LABELING - The present application is directed to compounds of Formula I: | 2012-03-22 |
20120071645 | TETRAHYDROPYRAN NUCLEIC ACID ANALOGS - The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran nucleoside analogs are provided, having one or more chiral substituents, that are useful for enhancing properties of oligomeric compounds including nuclease resistance and binding affinity. In some embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. | 2012-03-22 |
20120071646 | PROCESS FOR PRODUCING NUCLEOSIDE - There is a demand for a convenient production method of an NC type purine nucleoside. | 2012-03-22 |
20120071647 | Microfluidic reactor having an annular reaction chamber - A microfluidic reactor has a reaction chamber which is configured as an annular channel. It is provided that segments have been formed in the annular channel such that a sequence of inlets and outlets (allows an alternation between the process fluids (A and B) to take place. Furthermore, particles which circulate in the annular channel and can be used, for example, for the adsorption and desorption of ions may be provided in the annular channel. In this way, the ions concerned can, for example, be extracted from the process fluid (A) and transferred into the process fluid (B). In a method, the reactor can be used for example for the purpose of obtaining | 2012-03-22 |
20120071648 | METHOD FOR PRODUCING LACTAMATES BY WAY OF THIN FILM EVAPORATION - A method is described for producing lactamates by reacting alcoholates with lactams, wherein a reaction mixture comprising at least one alcoholate and at least one lactam is subjected to thin film evaporation. | 2012-03-22 |
20120071649 | PROCESS FOR THE PREPARATION OF QUETIAPINE FUMARATE - The present invention relates to an improved process for the preparation of quetiapine and pharmaceutically acceptable salts. It also relates to improved process for the preparation of intermediates of quetiapine. | 2012-03-22 |
20120071650 | METHOD FOR PRODUCING AMINOORGANOSILANES - The invention relates to a method (a) for producing aminoorganyltriorganylsilanes of the general formula (1) R′ | 2012-03-22 |
20120071651 | Processes for Preparing 1,2-Substituted Cyclopropyl Derivatives - The present invention relates to processes for preparing enantiomerically pure cyclopropyl amine derivatives and salts thereof; the chiral intermediates such as the chiral salts are useful for the preparation of such chiral compounds and salts; pharmaceutical compositions comprising the compounds and salts; and method of using such compositions. The chiral cyclopropyl amine derivatives are useful for binding to histamine H | 2012-03-22 |
20120071652 | Novel Piperazines, Pharmaceutical Compositions and Methods of Use Thereof - Disclosed are novel piperazine derivatives that act as agonists of the α7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds. | 2012-03-22 |
20120071653 | Human Adam-10 Inhibitors - The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. | 2012-03-22 |
20120071654 | ARYL ANILINE DERIVATIVES AS BETA2 ADRENERGIC RECEPTOR AGONISTS - The invention provides novel β | 2012-03-22 |
20120071655 | PROCESS FOR ENANTIOMERIC SEPARATION OF RACEMIC DIHYDRO-1,3,5, TRIAZINES VIA PREFERENTIAL CRYSTALLIZATION - A new process for the enantiomeric separation of racemic 3,6-dihydro-1,3,5-triazine derivatives for the treatment of disorders associated with insulin-resistance syndrome, by preferential crystallization. | 2012-03-22 |
20120071656 | PROCESS FOR PRODUCING SUBSTITUTED METHYLAMINE COMPOUND AND TRIAZINE DERIVATIVE - The present invention provides a process that enables a substituted methylamine compound which is useful as an intermediate for the production of agricultural chemicals and medicines, to be produced easily, with good yield, and at low cost, and also provides a production intermediate thereof. The process comprises a step of reacting a hexamethylenetetraammonium salt compound represented by a formula (I) with a base to obtain an N-methylidene-substituted methylamine oligomer represented by a formula (II) or a mixture of two or more of the oligomers, and a step of hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II) or the mixture of two or more of the oligomers in the presence of an acid. | 2012-03-22 |
20120071657 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS - This invention describes novel triazole compounds of formula IX: | 2012-03-22 |
20120071658 | PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITOR FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY - Provided herein are Heteroaryl Compounds having the following structure: | 2012-03-22 |
20120071659 | Process for the Preparation of Sufentanil Base and Related Compounds - The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously utilizes more cost effective and/or less hazardous reagents, including a dispersion comprising between about 50% and about 70% by weight (based on the total weight of the dispersion) of an alkali metal hydride, such as sodium hydride, as well as eliminates the need for expensive and/or time consuming purification techniques. | 2012-03-22 |
20120071660 | RESOLUTION OF (.+-.)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE - The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate. | 2012-03-22 |
20120071661 | Ionic Liquid Solvents - A chiral ionic compound comprising an alkyl substituted imidazolium or pyridinium cationic core having an alkyl ester side chain (-alkyl-C(O)O—) directly linked to the core and an associated counter anion, characterized in that the —O— atom of the ester side chain is linked to an alpha, a beta or a gamma hydroxycarboxylic acid functionality via the alpha, beta or gamma hydroxy of the acid functionality and the hydroxycarboxylic acid functionality has at least one asymmetric carbon, or characterized in that an —N═ atom of the alkyl substituted imidazolium or pyridinium cationic core is substituted with an alpha, a beta or a gamma hydroxy group of a alpha, a beta or a gamma hydroxycarboxylic acid functionality and the hydroxycarboxylic acid functionality has at least one asymmetric carbon. The chiral ionic liquids (CILs) may be used as novel solvents, in particular for organic synthesis. The CILs have the potential to induce asymmetry into substrates or catalysts in a variety of organic transformations. A number of the compounds have low antimicrobial and low antifungal toxicities and are also biodegradable CILs. | 2012-03-22 |
20120071662 | PREPARING AMINOARYLALKYL COMPOUNDS - The invention relates to a process for preparing aminoarylalkyl compounds, more particularly 5-amino-2-isopropylpyridine. | 2012-03-22 |
20120071663 | Preparation of N'-(4--2,5-dimethylphenyl)-N- ethyl-N-methylimidoformamide - The present invention relates to various processes for the preparation of N′-(4-{[3-(4-chloro-benzyl)-1,2,4-thiadiazol-5-yl]oxy}-2,5-dimethylphenyl)-N-ethyl-N-methylimidoformamide. | 2012-03-22 |
20120071664 | BETA-AMINO ACIDS AND METHODS AND INTERMEDIATES FOR MAKING SAME - Disclosed are β-amino acids that are unsubstituted in the β position; that are substituted in the β position with an aryl group; that are substituted in the α position with an aryl group; that bear two substituents in the α position; and/or that are substituted in the α and β positions with groups which, together with the carbon atoms at the α and β positions, form a ring. Also disclosed are methods for making the above-mentioned β-amino acids and other β-amino acids which involve providing an α,β-unsaturated imide; converting the α,β-unsaturated imide to a 2-substituted-isoxazolidin-5-one; and converting the 2-substituted-isoxazolidin-5-one to a β-amino acid. | 2012-03-22 |
20120071665 | METHOD FOR PRODUCING OLMESARTAN MEDOXOMIL - A method for producing high-purity olmesartan medoxomil is provided in which a solvent containing water is used in steps of tritylation and DMDO esterification of olmesartan. | 2012-03-22 |
20120071666 | Method for Purifying a Pyrazolinone Derivative - A method for purifying a pyrazolinone derivative comprising a step of mixing a solution containing a mixture containing the pyrazolinone derivative and a good solvent which can dissolve the pyrazolinone derivative with a poor solvent to crystallize the pyrazolinone derivative. | 2012-03-22 |
20120071667 | ACRYLATE DERIVATIVES, ALCOHOL DERIVATIVES, AND METHOD FOR PRODUCING THEM - Provided are an acrylate derivative useful as a raw material of a polymer compound for resist compositions capable of giving resist patterns which are excellent in lithographic performance and have a good shape, an intermediate thereof (alcohol derivative) and production processes for them. To be specific, it is an acrylate derivative represented by a formula shown below: | 2012-03-22 |
20120071668 | Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material - An object is to provide a novel carbazole derivative that has an excellent carrier-transport property and can be suitably used for a transport layer or as a host material of a light-emitting element. Another object is to provide an organic semiconductor material and a light-emitting element material each using the carbazole derivative. As the carbazole derivative that can achieve the above objects, a carbazole derivative in which a carbazolyl group whose either 2- or 3-position of carbazole is substituted by the 4-position of a dibenzothiophene skeleton or a dibenzofuran skeleton is bonded to aromatic hydrocarbon that has 14 to 70 carbon atoms and includes a condensed tricyclic ring, a condensed tetracyclic ring, a condensed pentacyclic ring, a condensed hexacyclic ring, or a condensed heptacyclic ring has been able to be synthesized. | 2012-03-22 |
20120071669 | PROCESS FOR PREPARATION OF ELETRIPTAN AND SALT THEREOF - The present invention relates to an improved process for the preparation of 3-(N-methyl-2(R)-pyrrolidinyl methyl)-5-[2-(phenyl sulfonyl)ethyl]-1H-indole or pharmaceutically acceptable salts thereof, particularly 3-(N-methyl-2(R)-pyrrolidinyl methyl)-5-[2-(phenyl sulfonyl)ethyl]-1H-indole hydrobromide (Eletriptan hydrobromide). The present invention further relates to novel polymorphs of 3-(N-methyl-2(R)-pyrrolidinyl methyl)-5-[2-(phenyl sulfonyl)ethenyl]-1H-indole hydrobromide and process for preparation thereof. | 2012-03-22 |
20120071670 | METHOD FOR PRODUCING OF ULTRA-CLEAN AND HIGH-PURITY N-METHYL PYRROLIDONE - The present invention provides a method for producing of ultra-clean and high-purity N-methyl pyrrolidone through using industrial grade N-methyl pyrrolidone as raw material. After the pretreatment, sorption and dehydration with 4A molecular sieve, twice membrane filtrations are carried out through using β-cyclodextrin composite membrane for the first and 18-crown-6 composite membrane for the second. The filtrate is rectified under vacuum and filtered through using complexant composite microporous membrane to obtain the product. The ultra-clean and high-purity N-methyl pyrrolidone, produced by the method provided by the present invention, is up to the SEMI C8 standard. And the purity of the product is over 99.8%, the moisture content is less than 0.03%, and the content of single metal ion is less than 1 ppb. Comparing to the prior art, the present invention has the advantage such as the stable quality of the product, simple operation, and is suitable for industrial continuous production. | 2012-03-22 |
20120071671 | CATALYST AND METHOD FOR PARTIALLY OXIDIZING HYDROCARBONS - The invention relates to a catalyst for partially oxidizing hydrocarbons in the gas phase, containing a multi-metal oxide of the general formula (I), AgaMObVcMdOe.f H2O (I), wherein M stands for at least one element selected from among Li, Na, K, Rb, Cs, Be, Mg, Ca, Sr, Ba, B, Al, Ga, In, Si, Sn, Pb, P, Sb, Bi, Y, Ti, Zr, Hf, V, Nb, Ta, Cr, W, Mn, Re, Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt, Cu, Au, Zn, Cd, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, and U, a has a value of 0.5 to 1.5, b has a value of 0.5 to 1.5, c has a value of 0.5 to 1.5, a+b+c has the value 3, d has a value of less than 1, e means a number that is determined by the valence and frequency of the elements other than oxygen in the formula (I), f has a value of 0 to 20, which multi-metal oxide exists in a crystal structure, the X-ray powder diffractogram of which is characterized by diffraction reflections at a minimum of 5 lattice distances selected from among d=4.53, 3.38, 3.32, 3.23, 2.88, 2.57, 2.39, 2.26, 1.83, 1.77 AA (+−0.04 AA). | 2012-03-22 |
20120071672 | PROCESS FOR PREPARING AROMATIC ALDEHYDE COMPOUND - An object of the present invention is to provide an industrially advantageous process for preparing a benzaldehyde compound from a benzyl alcohol compound with high yield. | 2012-03-22 |
20120071673 | SYNTHESIS OF (S)-N-[2-(1,6,7,8-TETRAHYDRO-2H-INDENO-[5,4-B]FURAN-8-YL)ETHYL]PROPIONAMI- DE - The present invention relates in general to the field of organic chemistry and in particular to the preparation of (S)—N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionamide, i.e. ramelteon, and analogues thereof. | 2012-03-22 |
20120071674 | SOLVATES OF DOCETAXEL - The present invention provides solvates of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1,7β,10β-trihydroxy-9-oxo-tax-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate and C2-3-alkyl esters of formic acid, process of their preparation and their use in the synthesis of the pharmaceutically pure 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1,7β,10β-trihydroxy-9-oxo-tax-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate. | 2012-03-22 |
20120071675 | METHOD FOR EXTRACTING MATERIALS AND DEVICE FOR IMPLEMENTING SAME - The invention can be used for extraction of valuable biologically active agents from vegetable, animal, fish, seafood, and other raw materials. | 2012-03-22 |
20120071676 | SYNTHESIS OF TERMINAL ALKENES FROM INTERNAL ALKENES AND ETHYLENE VIA OLEFIN METATHESIS - This invention relates generally to olefin metathesis, and more particularly relates to the synthesis of terminal alkenes from internal alkenes using a cross-metathesis reaction catalyzed by a selected olefin metathesis catalyst. In one embodiment of the invention, for example, a method is provided for synthesizing a terminal olefin, the method comprising contacting an olefinic substrate comprised of at least one internal olefin with ethylene, in the presence of a metathesis catalyst, wherein the catalyst is present in an amount that is less than about 1000 ppm relative to the olefinic substrate, and wherein the metathesis catalyst has the structure of formula (II) | 2012-03-22 |
20120071677 | Production of High Levels of DHA in Microalgae Using Modified Amounts of Chloride and Potassium - Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate | 2012-03-22 |
20120071678 | TRIHYDRIDOSILYL-TERMINATED POLYSILANES AND METHODS OF PREPARATION - Novel trihydridosilyl-terminated polysilanes and methods for their synthesis, which are applicable to other polysilanes, are provided. The synthetic methods provide for facile preparation of products with minimal handling of pyrophoric intermediates and byproducts. The novel compounds contain at least three silicon-silicon bonds and at least one terminal silicon atom having three hydrogen substituents. | 2012-03-22 |
20120071679 | PROCESS OF MAKING ALUMINOXANE AND CATALYSTS CONTAINING THUS PREPARED ALUMINOXANE - Processes for preparing aluminoxane comprising: bringing into contact under reaction conditions in an inert atmosphere a liquid containing reaction mixture comprising: (i) a water in oil emulsion comprising water and at least one emulsifier in a first hydrocarbon solvent; and (ii) an organoaluminum compound capable of forming aluminoxane in a second hydrocarbon solvent; provided that the aluminoxane produced by the reaction is present in solution under the reaction conditions. In a preferred embodiment a support carrier for the aluminoxane: (i) is present during the contact step or (ii) is introduced following contact. A polymerization catalyst can be prepared wherein the support carrier is SiO2 and a Group 3 to Group 10 metal containing single site complex is mixed with the aluminoxane. Catalysts suitable for polymerizing an olefin such as ethylene or copolymerizing an olefin with at least one C | 2012-03-22 |
20120071680 | SURFACE-MODIFIED ZIRCONIA NANOCRYSTAL PARTICLE AND METHOD FOR PRODUCING SAME - The invention provides a surface-modified zirconia nanocrystal particle, wherein the surface of the zirconia nanoparticle is modified by organic sulfonyloxy groups, and a method of producing a zirconia nanocrystal particle whose surface is modified by carbonyloxy groups, organic phosphoryloxy groups or aryloxy groups. This makes it possible a highly stable surface-modified zirconia nanocrystal particle having a solvent dispersibility by a simple method. Further, it is possible to the surface-modified zirconia nanocrystal particle of the invention is equipped with a surface modifier having a structure that can be easily substituted with a desired functional group according to use. Furthermore, it is possible to the method of producing the surface-modified zirconia nanocrystal particle which is capable of easily producing that. | 2012-03-22 |
20120071681 | PROCESS FOR PREPARING ORGANOMETALLOIDS - Disclosed are a process for preparing organometalloids functionalized with an unsymmetrical 1,1-disubstituted alkene, and compounds prepared therewith. | 2012-03-22 |
20120071682 | ORGANOSILICA NANOPARTICLES AND METHOD FOR MAKING - Preparation of Free-Flowing Organosilica Nanoparticles by Forming a solution of an organosilica nanoparticle precursor in a mixed solvent system comprising a first solvent and a second solvent, wherein the first solvent is different from the second solvent, wherein the second solvent has a boiling point which is greater than a boiling point of the first solvent, and wherein the nanoparticle precursor has a greater solubility in the first solvent than in the second solvent; removing at least 50% of the first solvent to form nanoparticles having a mean particle size less than about 25 nanometers dispersed in the solution; adding a coupling agent to the solution to facilitate reacting of the coupling agent with the nanoparticles; and recovering the nanoparticles from the solution, wherein the recovered nanoparticles have the mean particle size of less than about 25 nanometers | 2012-03-22 |
20120071683 | New Process - A process for the preparation of a compound of formula (I): | 2012-03-22 |
20120071684 | NOVEL FORMS OF CDDO METHYL ESTER - A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for example, from a saturated methanol solution. The glassy form displays an enhanced bioavailability over the non-hydrous crystalline form. Each form of CDDO methyl ester is a superior candidate for use, typically in solid dosage form, for treating a variety of disease states, generally associated with inflammation. | 2012-03-22 |
20120071685 | METHOD FOR PRODUCING BICYCLIC gamma-AMINO ACID DERIVATIVE - Methods for producing compounds having activity as an α | 2012-03-22 |
20120071686 | PRODUCTION OF DIESTERS FROM DINITRILE COMPOUNDS - Diesters are prepared by first hydrolyzing dinitrile compounds into imide compounds and then reacting such imide compounds with at least one alcohol. | 2012-03-22 |
20120071687 | PROCESS FOR PREPARING ACRYLIC ACID FROM ETHANOL AND FORMALDEHYDE - A process for preparing acrylic acid from ethanol and formaldehyde, in which, in a reaction zone A, the ethanol is partially oxidized to acetic acid in a heterogeneously catalyzed gas phase reaction, the product gas mixture A obtained and a formaldehyde source are used to obtain a reaction gas input mixture B which comprises acetic acid and formaldehyde and has the acetic acid in excess over the formaldehyde, and the formaldehyde present in reaction gas input mixture B is aldol-condensed with acetic acid present in reaction gas input mixture B to acrylic acid under heterogeneous catalysis in a reaction zone B, and unconverted acetic acid still present along-side the acrylic acid target product in the product gas mixture B obtained is removed therefrom, and the acetic acid removed is recycled into the production of reaction gas input mixture B. | 2012-03-22 |
20120071688 | PROCESS FOR PREPARING ACRYLIC ACID FROM METHANOL AND ACETIC ACID - A process for preparing acrylic acid from methanol and acetic acid, in which, in a reaction zone A, the methanol is partially oxidized to formaldehyde in a heterogeneously catalyzed gas phase reaction, the product gas mixture A obtained and an acetic acid source are used to obtain a reaction gas input mixture B which comprises acetic acid and formaldehyde and has the acetic acid in excess over the formaldehyde, and the formaldehyde present in reaction gas input mixture B is aldol-condensed to acrylic acid under heterogeneous catalysis in a reaction zone B with acetic acid present in reaction gas input mixture B, and unconverted acetic acid still present alongside the acrylic acid target product in the product gas mixture B obtained is removed therefrom, and the acetic acid removed is recycled into the production of reaction gas input mixture B. | 2012-03-22 |
20120071689 | PRODUCTION PROCESSES AND SYSTEMS, COMPOSITIONS, SURFACTANTS, MONOMER UNITS, METAL COMPLEXES, PHOSPHATE ESTERS, GLYCOLS, AQUEOUS FILM FORMING FOAMS, AND FOAM STABILIZERS - Production processes and systems are provided that include reacting halogenated compounds, dehalogenating compounds, reacting alcohol's, reacting olefins and a saturated compounds, reacting reactants having at least two —CF | 2012-03-22 |
20120071690 | PRODUCTION OF FORMAMIDES - A process is proposed for production of formamides by reaction of carbon dioxide with hydrogen in a hydrogenation reactor I in the presence of
| 2012-03-22 |
20120071691 | METHOD FOR SEPARATING A MIXTURE COMPRISING THREE COMPONENTS BY SIMULATED MOVING BED CHROMATOGRAPHY - A method for separating a mixture of components by simulated moving bed chromatography: (1) feeding the simulated moving bed such that the eluting power of the liquid phase in the second zone is greater than that of the liquid phase in the third zone, trapping the target component inside the second and the third zone; (2) a solvent for dissolving the mixture to be separated, instead of the feeding solution, is fed into the simulated moving bed through the feeding port, and the eluting power of the liquid phase in the second zone is maintained greater than that of the liquid phase in the third zone, thereby both the pre-impurity and the post-impurity are rinsed off completely, and the target component trapped in the second and the third zone is further purified; and (3) the target component trapped in the simulated moving bed is rinsed off the bed. | 2012-03-22 |
20120071692 | PROCESS FOR THE PREPARATION OF AROMATIC AMINES - A process for preparing an aromatic amine by reacting a corresponding aromatic alcohol with an aminating agent selected from the group consisting of ammonia, primary amines and secondary amines, in the presence of hydrogen and a catalyst molding, at a temperature of from 60-300°. The catalyst molding comprises Zr, Pd and Pt and has an annular tablet form with an external diameter in the range from 2-6 mm, a height in the range from 1-4 mm and an internal diameter of from 1-5 mm or a topologically equivalent form with the same volume. Catalyst moldings comprising Zr, Pd and Pt are also provided. The catalyst molding has an annular tablet form with an external diameter in the range from 3-6 mm, a height in the range from 1-4 mm and an internal diameter of from 2-5 mm or a topologically equivalent form. | 2012-03-22 |
20120071693 | PROCESS FOR THE PRODUCTION OF ETHYLENE GLYCOL AND RELATED COMPOUNDS - The present invention provide a process for the production of compounds of general formula (I), Y—CH | 2012-03-22 |
20120071694 | PROCESS FOR PREPARING AMINOALKYLNITRILES AND DIAMINES FROM SUCH NITRILES - A process for preparing a diamine from a corresponding aminoalkyl nitrile, which is prepared by reaction of a corresponding monoamine with a corresponding alkenyl nitrile in a continuous mode of operation, comprising the steps: a) introduction of the corresponding monoamine into a continuously conveyed reaction stream; b) introduction of the corresponding alkenyl nitrile into the reaction stream, with this already comprising the aminoalkyl nitrile on addition; c) reaction of the reaction stream in a first reaction region; d) at least partial transfer of the reaction stream into at least one second reaction region for further reaction; e) discharge of the reaction stream from the second reaction region after the reaction; f) introduction of the reaction stream discharged in step (a) into a reduction region; and g) reduction of the aminoalkyl nitrile present in the reaction stream to the corresponding diamine. | 2012-03-22 |
20120071695 | Synthetic Method of 5,5-Dimethyl-2,4-Adipaldehyde-0,0-Boron Difluoride - This invention, which involves synthetic method of 5, 5- dimethyl-2, 4-adipaldehyde-0, 0-Boron difluoride, belongs to the field of organic synthesis. Synthetic method of 5, 5-dimethyl-2, 4-adipaldehyde-0, 0-Boron difluoride is to react pinacolone and boron trifluoride diethyl ether at low temperature, and then add aqueous alkaline solution in after treatment to extract product from ether, after that, separate fluid, condense organic phase and final product is obtained. Yield of this method is 2 to 3 times higher than that in literature, and apart from that, mild reaction condition, simple procedures, easy operation, and low cost make it easy for industrial production. The product can be used directly in next step reaction without any special purification. | 2012-03-22 |
20120071696 | PROCESS FOR PREPARING 2-METHYL-3-(4-TERT-BUTYLPHENYL)PROPANAL WITH HIGH PARA-ISOMER PURITY - The present invention relates to a process for preparing 2-methyl-3-(4-tert-butyl-phenyl)propanal with high para-isomer purity, and also to a process for preparing 4-tert-butylbenzaldehyde with high para-isomer purity. | 2012-03-22 |
20120071697 | Method for Producing Ethanol - A method for producing ethanol by which ethanol can be synthesized from less fermentable biomass materials such as plant-derived materials and rice straws and industrial waste biomass materials such as wooden building materials and pulp and which can therefore broaden the range of raw materials for the production of ethanol. Specifically, a method for producing ethanol including reacting a raw material gas obtained by a thermochemical gasification reaction of biomass in the presence of a catalyst containing rhodium, at least one transition metal, and at least one element selected from lithium, magnesium and zinc. | 2012-03-22 |
20120071698 | PRODUCTION OF ETHANOL FROM METHANOL - A process for converting methanol to ethanol which comprises reacting methanol and carbon monoxide in the presence of a catalyst to produce a product comprising at least 25 mole % methyl acetate and, in some instances, acetic acid. The acetic acid then is reacted with at least one alcohol to produce at least one acetate selected from methyl acetate, ethyl acetate, and butyl acetate. The at least one acetate (if produced) and the methyl acetate produced as a result of reacting methanol and carbon monoxide then are hydrogenated to produce ethanol. Syngas may be produced from biomass to produce all or a portion of the methanol, hydrogen, and carbon monoxide requirements for the process. | 2012-03-22 |
20120071699 | Process For Preparing 3,3,3-Trifluoropropene - The invention provides a process for preparing 3,3,3-trifluoropropene (1243zf), the process comprising contacting a compound of formula CX | 2012-03-22 |
20120071700 | CATALYSTS FOR HYDROGENATION OF UNSATURATED HYDROCARBONS AND PREPARATIONS AND USES THEREOF - Disclosed are catalysts for hydrogenation of unsaturated hydrocarbons comprising at least one carrier, at least one active metallic component supported on the at least one carrier, and at least one silane group; and wherein the at least one active metallic component is chosen from palladium, platinum, nickel, copper, and ruthenium; the at least one silane group is grafted to the catalyst by silylation and is present in an amount ranging from 0.05% to 25% by weight relative to the total weight of the catalyst. Also disclosed are processes for the preparation of the catalysts and processes using the catalysts for hydrogenation of unsaturated hydrocarbons. | 2012-03-22 |
20120071701 | Integration of Cyclic Dehydrogenation Process with FCC for Dehydrogenation of Refinery Paraffins - A process for increasing light olefin yields from the fluidized catalytic cracking process. The process combines small units to treat the paraffinic components in the product streams from the fluidized cracking process. The paraffins are dehydrogenated and light olefins are separated. Heavier olefins are passed to an olefin cracking unit for increasing the yields of ethylene and propylene. | 2012-03-22 |
20120071702 | Chemical Reactor System and Method Using Regenerative Turbine Pump to Produce Fuel Gas - A pump system and controller for a chemical reactor for converting water and carbon dioxide into a fuel gas is provided. Carbon dioxide gas bubbles are created and introduced into pumped water and delivered to a regenerative turbine pump where bubbles are collapsed to produce an ionized gas and ionized liquid mixture containing hydrogen, hydroxyl radicals and hydroxide, which subsequently react with the carbon dioxide gas present in the bubble, reducing it to carbon monoxide, with further reactions yielding methane. | 2012-03-22 |
20120071703 | Method of immobilizing nuclear waste - Method of immobilizing nuclear waste comprising:
| 2012-03-22 |
20120071704 | MITOCHONDRIAL LOCALIZATION OF MUC1 - The invention provides methods of identifying and making compounds that inhibit the interaction between MUC1 and either or both of HSP70 and HSP90. Also embraced by the invention are in vivo and in vitro methods of inhibiting such an interaction. | 2012-03-22 |
20120071705 | BRACHYTHERAPY DEVICE FOR ASYMMETRICAL IRRADIATION OF A BODY CAVITY - The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity. | 2012-03-22 |
20120071706 | SYSTEM AND METHOD FOR ELICITING A RELAXATION RESPONSE - The disclosed system and method are directed to qualifying an image(s) and exposing an individual to the qualified image(s) for the purpose of eliciting a relaxation response. More specifically, a sequential rendition of qualified images are presented to either a normal or cognitively impaired person in order to elicit relaxation and/or reduce agitation. Qualified images include those with both particular natural landscape content or elements (e.g., low vegetative growth, an open area, trees, a horizon, a visible sky, an absence of any man-made structures, and fresh water) and a particular average fractal dimension. | 2012-03-22 |
20120071707 | MEDICAL DEVICE - A tubular non-woven soft tissue implant has cell patterns. The cell pattern has a continuous circumferential construction with atraumatic edges and a tubular centre. The implant is suitable for stabilising and/or supporting body tissue for example to treat urinary incontinence and/or pelvic floor prolapse. | 2012-03-22 |
20120071708 | Implantable Sling Having Bladder Support - Surgical implants operative to simultaneously function as a pubovaginal sling for the treatment of incontinence and as a support member to effectuate cystocele repair. The implant comprises a first sling portion operative to be positioned beneath the urethra, per conventional pubovaginal sling surgery. The implant further includes a second bladder support portion extending from the sling support portion that is oriented to extend beneath and be surgically attached to a portion of the bladder to thus enable the same to be supported to a degree necessary to effectuate cystocele repair. The implant may be fabricated from a unitary piece of harvested tissue, synthetic material or combinations thereof. Preferably, the sling portion of the implant is fabricated from a synthetic material whereas the bladder support portion of the implant comprises a segment of harvested tissue sewn to the sling portion. | 2012-03-22 |
20120071710 | ENDOSCOPIC SMART PROBE AND METHOD - An improved endoscopic device which is introduced into the intestinal tract of a living organism and which operates autonomously therein, adapted to obtain and store or transmit one or more types of data such as visual image data, laser autofluorescence data, or ultrasonic waveform data. In another aspect of the invention, an improved endoscopic device useful for implanting the aforementioned endoscopic smart probe is disclosed. In another aspect of the invention, apparatus for delivering agents including nano structures, radionuclides, medication, and ligands is disclosed. In another aspect of the invention, apparatus for obtaining a biopsy of intestinal tissue is disclosed. In another aspect of the invention, apparatus for detecting the presence of one or more molecular species within the intestine is disclosed. Methods for inspecting and/or treating the interior regions of the intestinal tract using the aforementioned apparatus are also disclosed. | 2012-03-22 |
20120071711 | SURGICAL INSTRUMENTS AND BATTERIES FOR SURGICAL INSTRUMENTS - Various embodiments are directed to battery packs for use with surgical instruments. The battery packs may comprise a plurality of cells and at least a portion of the plurality of cells may not be electrically connected to one another. The battery packs may comprise a switch or other mechanism for interconnecting the plurality of cells and may also comprise, or be used in conjunction with, a discharge switch or plug configured to electrically connect an anode of the battery pack to a cathode of the battery pack, for example, via a resistive element. | 2012-03-22 |
20120071712 | HEATED BALLOON CATHETER - Thermally adjustable surgical tools include a conductor and a ferromagnetic material. The ferromagnetic material may be quickly heated when subjected to high frequency alternating current through the conductor. The ferromagnetic material may also cool rapidly because of its relatively low mass and the small thermal mass of the conductor. The thermally adjustable surgical tools may be used to sculpt, melt, break and/or remove biological material. The thermally adjustable surgical tools may also include balloon catheters which can heat fluid to thereby treat biological material. | 2012-03-22 |
20120071713 | BIOPSY INLET VALVE IMPROVEMENTS - A valve apparatus device provides surgical instruments with sealable access to an inlet port of an endoscope instrument channel. The valve has a hollow body with a distal end that releasably attaches to the inlet port, and a flexible diaphragm seal dividing the body into a proximal chamber and a distal chamber. An instrument opening extends through the diaphragm seal for the passage of instruments therethrough, and connects the chambers together. The diaphragm seal is configured to seal with a surgical instrument inserted into the instrument opening. At least one fluid transfer member is provided to fluidly interconnect the proximal chamber to the distal chamber when the surgical instrument is sealed within the instrument opening. | 2012-03-22 |
20120071714 | CANNULOTOME - Systems and methods for treating spinal stenosis include endoscopic access devices and bone removal devices used to perform a foraminotomy or other bone removal procedures. A bone removal device includes a cannulotome with an endoscopic imaging lumen. Optionally, an endoscope retaining device can be used to facilitate advancement of the endoscope through the cannulotome. | 2012-03-22 |
20120071715 | MATERIAL DELIVERY SYSTEM - A method for injecting a therapeutic agent into a target tissue, the method comprising: (a) providing an expandable member; (b) positioning said expandable member in proximity to the target tissue; (c) Introducing the therapeutic agent into the expandable member until a desired pressure is achieved; and (d) creating a plurality of small apertures in the expandable member. | 2012-03-22 |