12th week of 2012 patent applcation highlights part 46 |
Patent application number | Title | Published |
20120071314 | ENERGY STORAGE CERAMIC DIELECTRIC COMPONENT AND METHOD THEREOF - The present invention is a new composition of matter and can be used as components of a capacitor. The dielectric properties possess in this material has improved tremendously as compared to the existing component. The finding of high dielectric permittivity in the present invention ceramic according to its formulation and processing technique that can operate or use at wide range frequencies and temperatures are very useful in electronic and electrical devices. The present invention is best for applications at the range of temperatures. The permittivity is recorded at 1 kHz are between ˜20,000 to ˜54,000 and almost constant over three decade of frequency. Thus, the dielectric permittivity obtained can be used as energy storage, sensor, electric filter, etc., besides minimizing the devices size. | 2012-03-22 |
20120071315 | Cordierite-Forming Batch Materials And Methods Of Using The Same - The present disclosure relates to cordierite-forming batch materials and methods of using the same, and in particular batch materials for forming porous cordierite bodies suitable for treating engine emissions. The batch materials include sources of magnesium, alumina, silica, and high BET specific surface area raw kaolin clay. In some embodiments, the BET specific surface area of the raw kaolin clay is greater than 22 m | 2012-03-22 |
20120071316 | METHOD FOR CONDITIONING CATALYSTS BY MEANS OF MEMBRANE FILTRATION - The present invention relates to a method of conditioning suspended catalysts, wherein at least part of the catalyst-comprising reaction medium is taken from one or more reactors and the suspended, at least partially inactivated catalysts are separated off and purified by means of at least one membrane filtration, with at least one of the membrane filtrations being carried out as a diafiltration. | 2012-03-22 |
20120071317 | TOLUENE DISPROPORTIONATION USING Nb/MORDENITE CATALYST - A molecular sieve catalyst useful in the conversion of hydrocarbons containing niobium is disclosed, along with a process for the disproportionation of toluene to benzene and xylene using such catalyst. | 2012-03-22 |
20120071318 | EXHAUST GAS-PURIFYING CATALYST - An exhaust gas-purifying catalyst includes a substrate, and a catalytic layer facing the substrate and including a precious metal, alumina, an oxygen storage material, and a sulfate of an alkaline-earth metal having an average particle diameter falling within a range of 0.01 to 0.70 μm, the average particle diameter being obtained by observation using a scanning electron microscope. Another exhaust gas-purifying catalyst includes a substrate, and a catalytic layer formed on the substrate using slurry containing a precious metal, alumina, an oxygen storage material, and a sulfate of an alkaline-earth metal having an average particle diameter falling within a range of 0.01 to 0.70 μm, the average particle diameter being obtained by observation using a scanning electron microscope. | 2012-03-22 |
20120071319 | SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES - Compounds of the formula (I) useful as pesticides are disclosed, wherein the substituents are as defined in claim | 2012-03-22 |
20120071320 | LIQUID AGRICULTURAL FORMULATIONS OF IMPROVED STABILITY - Agricultural oil dispersions of improved stability and processes to make and methods to use such compositions are disclosed. The compositions are comprised of an active ingredient coated with one or more non-oil soluble polymers that hinder degradation of the active ingredient by other ingredients. | 2012-03-22 |
20120071321 | DISPERSANTS IN HIGH-ELECTROLYTE SOLUTIONS - Embodiments of the present invention disclose a composition of an electrolyte solution comprising a water-soluble active ingredient; a water-insoluble solid active ingredient; and a dispersant that consists of a polyaminoamide resin, a polyoxyalkylene derivative thereof, a polyglycerol derivative thereof, a polycarbamate derivative thereof and a combination thereof. | 2012-03-22 |
20120071322 | Substituted Pyridopyrazines with a Herbicidal Action - Substituted pyrazines of the formula I | 2012-03-22 |
20120071323 | HERBICIDAL FORMULATIONS - The invention includes an aqueous compatibilized herbicidal formulation. In typical embodiments, formulations comprise a diammonium salt of glyphosate and a sodium salt of fomesafen. The invention also includes storage and transport systems containing formulation embodiments. The invention also includes methods inhibiting unwanted plant growth. | 2012-03-22 |
20120071324 | Biocidal substances - The present invention relates to biocidal and more particularly algicidal substances comprising one or more polymers which in turn comprise one or more biocides such as more particularly algicides, where at least one polymer has structural elements which derive from acrylonitrile. The invention further relates to biocidal compositions comprising aforesaid biocidal substances in particulate form, to a process for preparing the biocidal substances and the biocidal compositions and to the use of the biocidal compositions for protecting technical materials. | 2012-03-22 |
20120071325 | USE OF AMIDE COMPOUND FOR PROMOTING PLANT ROOT GROWTH - The present invention relates to use of amide compounds for promoting root growth of plants. | 2012-03-22 |
20120071326 | QUENCH PROTECTION CIRCUIT FOR SUPERCONDUCTING MAGNET COILS - A superconducting magnet includes at least one superconducting coil and a quench protection circuit electrically coupled to said at least one coil in parallel. The circuit includes at least one quench heater assembly thermally coupled to the at least one coil, and at least one superconducting current limiter electrically connected in series with the at least one quench heater assembly. The superconducting current limiter has a superconducting state with zero resistance, and a normal state with a normal resistance to decrease an electric current flowing through the quench heater assembly. | 2012-03-22 |
20120071327 | INDEXING OF NUCLEIC ACID POPULATIONS - The invention relates to a method for acquisition of genetic information, in particular for personalized medicine. | 2012-03-22 |
20120071328 | Complexity management of Genomic DNA - The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms. | 2012-03-22 |
20120071329 | METHODS FOR IDENTIFYING COMPOUNDS OF INTEREST USING ENCODED LIBRARIES - The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag. | 2012-03-22 |
20120071330 | MULTIPLEXED IDENTIFICATION OF NUCLEIC ACID SEQUENCES - A method for the rapid identification of a target nucleic acid sequence is provided, as well as corresponding devices, products and kits. Such methods are useful for the rapid detection, identification and/or quantification of target nucleic acid sequences associated with, for example, a pathogen. | 2012-03-22 |
20120071331 | INCREASING CONFIDENCE OF ALLELE CALLS WITH MOLECULAR COUNTING - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 2012-03-22 |
20120071332 | Method for Quantification of Small RNA Species - The present invention relates to a method for amplification and quantification of microRNA molecules using quantitative reverse transcription polymerase chain reaction (qRT-PCR) technology. The method comprise the steps of (a) producing cDNA molecules complementary to microRNAs in a sample using polyadenylation and primer extension by reverse transcription, and (b) amplification and quantification of the cDNAs by qPCR using microRNA specific primer sets of forward and reverse primers containing LNA monomers. | 2012-03-22 |
20120071333 | USES OF SYSTEMS WITH DEGREES OF FREEDOM POISED BETWEEN FULLY QUANTUM AND FULLY CLASSICAL STATES - Disclosed herein are systems and uses of systems operating between fully quantum coherent and fully classical states. Such systems operate in what is termed the “Poised realm” and exhibit unique behaviors that can be applied to a number of useful applications. Non-limiting examples include drug discovery, computers, and artificial intelligence | 2012-03-22 |
20120071334 | Methods And Marker Combinations For Screening For Predisposition To Lung Cancer - The present invention relates to rapid, sensitive methods for determining whether a subject has or is at risk of developing lung cancer based on certain combinations of biomarkers, or biomarkers and biometric parameters. The methods consist of: a) quantifying in a test sample obtained from a subject, the amount of two or more biomarkers in a panel, the panel comprising at least one antibody and at least one antigen: b) comparing the amount of each biomarker quantified in the panel to a predetermined cutoff for said biomarker and assigning a score for each biomarker based on said comparison: c) combining the assigned score for each biomarker quantified in step b to obtain a total score for said subject: d) comparing the total score in step c with a predetermined total score and e) determining whether said subject has a risk of lung cancer based on the comparison in step d. | 2012-03-22 |
20120071335 | Method for Identification, Selection and Analysis of Tumour Cells - The present invention relates to a method for the diagnosis of tumoural conditions and/or of the corresponding state of advance, wherein a specimen of an organic fluid taken from the patient and having a high probability of containing at least one circulating tumour cell (CTC) or a disseminated tumour cell (CTD) is enriched in a population of CTCs or CTDs. According to the invention, at least one type of CTCs or CTDs is isolated by selecting individually single cells in a microfluidic device so to constitute a diagnostic specimen having a purity of at least 90%. On the specimen thus obtained there is subsequently performed a molecular analysis such as to highlight a characteristic thereof suited to enabling diagnosis. | 2012-03-22 |
20120071336 | Antibiotic resistance profile for Neisseria gonorrhoeae and use of same in diagnosis and treatment of gonorrhea - The present invention relates to an antibiotic resistance profile for | 2012-03-22 |
20120071337 | METHODS - The invention provides a method for aiding the diagnosis or prognostic monitoring of Alzheimer's disease in a subject, said method comprising; providing a sample of blood obtained from said patient; assaying the amount of gelsolin present in said sample; comparing the amount of gelsolin present in said sample to a reference amount of gelsolin present in a sample from a healthy subject, wherein detection of a gelsolin level in the sample from said patient which is lower than the gelsolin level in the reference sample indicates an increased likelihood of Alzheimer's disease in said patient. Other markers are C1 protease inhibitor and ceruloplasmin. Both blood samples and tissue samples have been investigated. | 2012-03-22 |
20120071338 | POLYMERIZATION-BASED AMPLIFICATION FOR IMMUNOSTAINING AND BIODETECTION - The invention provides polymerization-based signal amplification methods in which labeling moieties are incorporated into a polymer mass or film formed at a biorecognition site. When the labeling moieties are fluorescent, the invention can be used to provide an immunofluorescent staining method which is non-enzymatic. The invention also provides kits useful for the immunofluorescent staining methods of the invention. | 2012-03-22 |
20120071339 | BIOMARKERS - The invention relates to a method of diagnosing or monitoring multiple sclerosis. | 2012-03-22 |
20120071340 | BIOMARKERS - The invention relates to a method of diagnosing or monitoring major depressive disorder. | 2012-03-22 |
20120071341 | NOVEL METHODS FOR PREDICITING AND TREATING TUMORS RESISTANT TO DRUG, IMMUNOTHERAPY AND RADIATION - The present invention relates to methods for prognosis, diagnosis, and treatment of malignant tumors that were treatment resistant. The present invention provides methods of prognosis and diagnosis of multidrug resistant tumors through detection of the expression levels of nuclear co-repressor 2 (“N-CoR2”), histone deacetylases 3 (“HDAC3”), and their associated gene expression biomarkers. The present invention also provides methods of sensitizing tumors to anti-tumor therapeutics by disrupting HDAC3 activation, abrogating the N-CoR2-HDAC3 interaction, inhibiting the activity of either protein, or by downregulating the expression of either protein. | 2012-03-22 |
20120071342 | SYSTEM AND METHOD FOR DETECTING MULTIPLE MOLECULES IN ONE ASSAY - A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample. | 2012-03-22 |
20120071343 | BIOMARKERS FOR DIFFERENTIATING MELANOMA FROM BENIGN NEVUS IN THE SKIN - Disclosed is a method for diagnosing melanoma in a human subject, as well as a method for providing a prognosis to a human subject who is at risk of developing melanoma recurrence, and a method for determining the stage of melanoma in a human subject, comprising the step of determining the level of expression of phosphatase and actin regulator 1 (PHACTR1) gene, or fragments thereof, either alone or in combination with the level of expression of secreted integrin-binding phosphoprotein (SPP1), preferentially expressed antigen in melanoma (PRAME), growth differentiation factor 15 (GDF 15), and chemokine C-X-C motif ligand 10 (CXCL10) genes. Further, the invention relates to a diagnostic kit, comprising at least one substance for detection of the expression of PHACTR1, or fragments thereof, either alone or in combination with the detection of SPP1, PRAME, GDF15, and CXCL10, for the diagnosis or prognosis of melanoma. | 2012-03-22 |
20120071344 | COMPOSITIONS AND METHODS FOR IDENTIFYING ENZYME AND TRANSPORT PROTEIN INHIBITORS - The invention is directed to compositions, e.g., cell-based and multiplexed platforms, to screen for small molecule drugs that inhibit enzymes such as proteases, e.g., viral proteases, e.g., HIV proteases; and methods for making and using these compositions. The invention provides compositions and methods for identifying compositions, e.g., drug molecules, that can inhibit proteases, e.g., viral proteases such as HIV proteases. In alternative embodiments, the invention provides cell-based platforms or assays to screen for compositions, e.g., small molecules or drugs, that inhibit or modify the activity of enzymes such as calcium-dependent protein convertases involved in HIV envelope protein processing, including cleavage of the HIV gp160 envelope precursor, resulting in gp120 and gp41 envelope products. In one embodiment, the invention provides a cell-based or multiplexed platform for monitoring the activity of enzymes, e.g., proteases such as viral proteases. | 2012-03-22 |
20120071345 | SINGLE COLUMN IMMUNOLOGICAL TEST ELEMENTS - A plurality of individual single column test elements are provided for use in a clinical testing apparatus. Each test element is defined by a single test column that includes a quantity of a test material, such as gel material or a bead matrix, including a cover strip used to access the contents of the test column. Individual test elements can be stored, retained and dispensed for testing patient samples. | 2012-03-22 |
20120071346 | GENE-BASED ALGORITHMIC CANCER PROGNOSIS - The present invention is related to the methods and systems for prognosis determination in tumor samples, by measuring gene expression in a tumor sample and applying a gene-expression grade index (GGI) or a relapse score (RS) to yield a number c risk score. | 2012-03-22 |
20120071347 | COMPOSITIONS AND METHODS FOR MONITORING AND DETECTING CANCEROUS CONDITIONS - A method for monitoring or detecting a prostate condition in a subject comprises determining Engrailed-2 (EN2) gene, Paired Box 2 (PAX2) gene, and/or β defensin-1 (DEFB1) gene expression levels in a biological sample from the subject. The expression levels of EN2, PAX2 and/or DEFB1 gene are correlated with cancerous, pre-cancerous, or non-cancerous prostate conditions. | 2012-03-22 |
20120071348 | METHODS FOR LARGE SCALE FUNCTIONAL EVALUATION OF NUCLEOTIDE SEQUENCES IN PLANTS - The present invention provides for rapid and large scale evaluation of expression of, or function of, nucleotide sequences in plants. The invention comprises three specific components which provide for fast and large scale evaluation of nucleotide sequences. The first component includes delivery in either a single event a library of different engineered vectors or a single engineered vector for a single target nucleotide sequence comprising sequences the function of which is desired to be known in plant cells. Surprisingly, applicants have discovered that, the introduction of multiple vectors to plant cells predominantly results in individual transgenic plants which contain only a single transformation event. The second feature of the invention involves a highly transformable, fast cycling and/or miniature size plant and the final step involves mass scale analysis of T0 plants for various phenotypes and plasmid rescue to identify the nucleotide sequence present in a particular phenotype. | 2012-03-22 |
20120071349 | NOVEL ANTI-AGING AGENTS AND METHODS TO IDENTIFY THEM - The present invention discloses novel mechanisms in the aging process and describes novel methods for high-throughput screening to identify, detect, and purify agents to be used for improving mitochondrial function, maintaining the cell cycle-arrested state in senescent and post mitotic cells, and thus preventing or treating age-related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and/or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions identified from this method. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders. | 2012-03-22 |
20120071350 | TUMOR-INITIATING CELLS AND METHODS FOR USING SAME - Isolated and enriched tumor-initiating cell populations, methods for preparing the same, and uses thereof. | 2012-03-22 |
20120071351 | LABEL FREE BIOSENSORS AND CELLS - Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in highthough put methods and can be multiplexed. | 2012-03-22 |
20120071352 | Non-labeled virus detection substrate, system, and method based on inverted multi-angular cavity arrays - The present invention discloses a non-labeled virus detection substrate, system, and method based on inverted multi-angular cavity arrays. The virus detection substrate is used together with a Raman spectrometer for virus detection. The virus detection substrate has a metal layer disposed thereon, and inverted multi-angular cavities are formed in the metal layer. The cavities are arranged in a microarray. In order to detect the target, the size of the cavities should be adjusted first. Then, a laser with an optimized wavelength is applied to induce the effect of the surface enhanced Raman scattering. | 2012-03-22 |
20120071353 | APPARATUS AND METHOD FOR PERFORMING NUCLEIC ACID ANALYSIS - The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis. | 2012-03-22 |
20120071354 | NORMALIZED NUCLEIC ACID LIBRARIES AND METHODS OF PRODUCTION THEREOF - The present invention relates generally to methods for producing normalized nucleic acid libraries in which each member of the library can be isolated with approximately equivalent probability. In particular, the present methods comprise subtractive hybridization of a nucleic acid library with haptenylated (e.g., biotinylated, avidinated or streptavidinated) nucleic acid molecules that are complementary to one or more of the nucleic acid molecules of the library, such that the variation in the abundances of the individual nucleic acid molecules in the library is reduced. The invention also relates to production of normalized nucleic acid libraries (particularly cDNA libraries) in which contaminating nucleic acid molecules have been reduced or eliminated, and to normalized nucleic acid libraries produced by such methods. | 2012-03-22 |
20120071355 | Microarray system - A microarray system is disclosed. The microarray system includes a microarray formed on a planar substrate and an incubation chamber formed around the microarray. The incubation chamber has a plurality of interior surfaces including a bottom surface on which the microarray is formed and a top surface that faces the bottom surface and is generally parallel to the bottom surface. At least one of a plurality of interior surfaces is a hydrophilic surface. | 2012-03-22 |
20120071356 | Variants in Complement Regulatory Genes Predict Age-Related Macular Degeneration - Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including polymorphisms in the BF, C2 and/or CFH genes. Microarrays and kits for use in these methods are also provided. | 2012-03-22 |
20120071357 | METHODS AND SYSTEMS FOR UNIFORM ENRICHMENT OF GENOMIC REGIONS - The present invention provides methods and compositions for the enrichment of target nucleic acids in a microarray system. In particular, the present invention provides methods and compositions for uniform enrichment of target nucleic acid molecules in a microarray format. The present invention also provides for intentionally non-uniform enrichment among target nucleic acid molecules. | 2012-03-22 |
20120071358 | Fluidic devices and methods for multiplex chemical and biochemical reactions - The present invention describes microfluidic devices that provide novel fluidic structures to facilitate the separation of fluids into isolated, pico-liter sized compartments for performing multiplexing chemical and biological reactions. Applications of the novel devices including biomolecule synthesis, polynucleotide amplification, and binding assays are also disclosed. | 2012-03-22 |
20120071359 | PURIFIED EXTENDED POLYMERASE/TEMPLATE COMPLEX FOR SEQUENCING - Methods, Compositions, and Systems are provided for obtaining polymerase-template complex mixtures with improved levels of active polymerase. In some aspects, methods are described in which a polymerase-template complex is exposed to reaction conditions in which a complementary strand to the template is produced. The extended reaction mixture is purified, for example by gel filtration chromatography to produce a mixture of polymerase-template complex having a higher active fraction. This purified mixture can be used for further analyses including single molecule sequencing. | 2012-03-22 |
20120071360 | ALKALINE SHOCK-BASED METHOD OF PROCESSING A BIOLOGICAL SAMPLE - Method of processing a biological sample to yield nucleic acid appropriate for use in a subsequent in vitro nucleic acid amplification reaction. The method involves a rapid, transient exposure to alkaline conditions which can be achieved by mixing an alkaline solution with a pH-buffered solution that includes a detergent and the biological sample to be tested for the presence of particular nucleic acid species using in vitro amplification. The invented method advantageously can improve detection of some target nucleic acids without substantially compromising detectability of others. The method is particularly useful for simultaneously preparing RNA and DNA templates that can be used in multiplex amplification reactions. | 2012-03-22 |
20120071361 | Substrate Preparation Process - The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays. | 2012-03-22 |
20120071362 | NONWOVEN-BASED CHEMI-CAPACITIVE OR CHEMI-RESISTIVE GAS SENSOR - A chemical gas sensor formed from a nonwoven material is described. The gas sensor includes a flexible, gas-permeable, nonwoven web-based material substrate having a matrix that is composed of a plurality of inert thermoplastic, pulp, cellulose or staple fibers as either a major or minor portion, with a plurality of gas-sensitive fibers formed from a polymer that can absorb volatile organic compounds (VOC), and a plurality of electrically conductive fibers. The gas-sensitive fibers are intermixed with and associated spatially among a network of adjacent electrically conductive fibers, such that a change in physical morphology of said gas-sensitive fibers as a result of interacting with volatile organic compounds, causes a change in dielectric properties that disrupts said network of adjacent electrically conductive fibers. The sensor can be configured as either a resistive or a capacitive chemisensor. | 2012-03-22 |
20120071363 | METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis. | 2012-03-22 |
20120071364 | DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING THE LIGASE DETECTION REACTION WITH ADDRESSABLE ARRAYS - The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support. | 2012-03-22 |
20120071365 | Detection Device Having Increased Detection Rate, and Method for Quick Detection of Biological Molecules - A biological molecule detection device that includes a detection array, arranged on a body and having one or more probes for detecting corresponding electrically charged molecules, wherein a time varying electric field generating circuit is provided for generating at least one time varying electric field around the detection array within the detection region. The time varying electric field moves the electrical charged molecules repeatedly back and forth over the probes, thus providing increased opportunities for interaction and speeding the detection process. | 2012-03-22 |
20120071366 | COMPLEMENTARY SURFACTANT COMPOSITIONS AND METHODS FOR MAKING AND USING SAME - Complementary surfactant systems and downhole fluids made using the systems are disclosed along with methods for making and using same, where the surfactant systems include from 0 wt. % to 100 wt. % of a first surfactant subsystem, from 100 wt. % to 0 wt. % of a second surfactant subsystem, and from 0 wt. % to 100 wt. % of a solvent subsystem based on the wt. % of the surfactant subsystems, where the system is tailored to foam the fluid including the analyzed crude and/or condensate. | 2012-03-22 |
20120071367 | ENVIRONMENTALLY FRIENDLY BASE FLUIDS AND METHODS FOR MAKING AND USING SAME - Non-toxic, biodegradable base fluids are disclosed for use in making downhole fluids, where the base fluids include blends of paraffins, olefins, naphthenes, esters, and oxygenates, having low viscosities, having a pale-yellow color, having a flashpoint of >80° C. (175° F.) and have a pour point of about 19° F. Methods for making and using fluids include the base fluids of this invention are also disclosed | 2012-03-22 |
20120071368 | Drilling Fluid for Enhanced Rate of Penetration - A drilling fluid is provided which results in an enhanced rate of penetration, and more particularly, a drilling mud composition is provided with a reduced ester content which maintains an enhanced rate of penetration. | 2012-03-22 |
20120071369 | Environment Friendly Base Fluid to Replace the Toxic Mineral Oil-Based Base Fluids - Processes for producing alkyl esters useful as base fluids in oil-based mud compositions. The alkyl esters are produced from raw material waste oil that include vegetable oil. The raw material waste oil can be obtained from the food industry, such as from food chains. The raw material waste oil is purified by removing impurities from it. The raw material waste oil is then esterified with an alcohol in the presence of a catalyst. The resulting alkyl ester products are then separated from triglycerides. The alkyl ester products are then washed and dried. | 2012-03-22 |
20120071370 | DEFOAMER FORMULATION AND METHODS FOR MAKING AND USING SAME - Defoamer compositions are disclosed and methods for making and using same, where the defoamer has universal applicability at low concentrations. The defoamer compositions include between 40 vol. % and about 80 vol. % distilled water (other waters may be used instead), 10 vol. % and about 30 vol. % of silicon anti-foam agent and between about 10 vol. % and about 30 vol. % of active silicon anti-foam agent. The defoamer compositions are used in amount of less than or equal to 200 ppm in all foamed downhole fluid systems. | 2012-03-22 |
20120071371 | AQUEOUS PARTICULATE SLURRY COMPOSITIONS AND METHODS OF MAKING SAME - A sand slurry composition and a method for making sand slurries are disclosed. The sand slurry composition is comprised of sand, an aqueous liquid and a chemical compound that renders the surface sand of hydrophobic. The method is comprised of rendering sand surface hydrophobic during or before making the slurry. This method and composition can find many applications in different industries, especially in various oil field applications. | 2012-03-22 |
20120071372 | PREVENTION AND REMEDIATION OF WATER AND CONDENSATE BLOCKS IN WELLS - The present invention relates to a method of removing and preventing water and condensate blocks in wells by contacting a subterranean formation with a composition comprising a low molecular weight fluorinated copolymer having perfluoro alkyl moieties which are no longer than C | 2012-03-22 |
20120071373 | LUBRICANT OIL COMPOSITION - A lubricant oil composition according to the present invention comprises: a lubricant base oil whose kinematic viscosity at 100° C. is 1 to 20 mm | 2012-03-22 |
20120071374 | LUBRICANT OIL COMPOSITION - A lubricant oil composition comprising: a lubricant base oil whose kinematic viscosity at 100° C. is 1 to 6 mm | 2012-03-22 |
20120071375 | LUBRICANT OIL COMPOSITION - The invention provides a lubricating oil composition comprising a lubricating base oil with a kinematic viscosity at 100° C. of 1-10 mm | 2012-03-22 |
20120071376 | Monitoring Cleaning of Surfaces - A method for monitoring cleaning of a surface includes applying an amount of transparent indicator material to an area of a surface and measuring the amount of transparent indicator material remaining on the surface. The transparent indicator material may be fixed on the surface by drying and, when a fluorescent material, may be measured through exposure to ultraviolet radiation. | 2012-03-22 |
20120071377 | ENGINE CLEANING COMPOSITION AND METHOD FOR CLEANING THE ENGINE - The present invention provides a method of cleaning an engine having at least one combustion chamber, and the method includes the steps of providing an engine cleaning composition and introducing the cleaning composition into the combustion chamber. The engine cleaning composition includes: (i) 10-100 wt % of an alkanol amine hydroxy carboxylate represented by formula (I): RCHOHCOONH | 2012-03-22 |
20120071378 | LIQUID CLEANING COMPOSITION - The present invention relates to a liquid, cleaning composition comprising abrasive cleaning particles. | 2012-03-22 |
20120071379 | LIQUID CLEANING COMPOSITION - The present invention relates to a liquid, cleaning composition comprising abrasive cleaning particles. | 2012-03-22 |
20120071380 | LIQUID CLEANING COMPOSITION - The present invention relates to a liquid, cleaning composition comprising coloured abrasive cleaning particles. | 2012-03-22 |
20120071381 | PROCESS FOR THE PREPARATION OF A SPRAY POWDER COMPRISING ONE OR MORE GLYCINE-N,N-DIACETIC ACID DERIVATIVES AND USE OF THE SPRAY POWDER FOR PRODUCING COMPRESSION AGGLOMERATES - A process for the preparation of a spray-dried powder containing at least one glycine-N,N-diacetic acid compound of a formula MOOC—CHR—N(CH | 2012-03-22 |
20120071382 | NON-FLUOROPOLYMER SURFACE PROTECTION COMPOSITION - The present invention encompasses a surface treatment composition which comprises a polyorganosiloxane fluid-silicone resin mixture and a carrier. The polyorganosiloxane fluid-silicone resin mixture comprises about 2% to about 95%, by weight of the mixture, of one or more polyorganosiloxane fluid compounds; from about 1% to about 10%, by weight of the mixture, of one or more silicone resin, a protonation agent, at least about 5%, by weight of the mixture; of water; and optionally, less than about 5%, by weight of the mixture, of an emulsifier. | 2012-03-22 |
20120071383 | LIQUID DETERGENT COMPOSITION WITH ABRASIVE PARTICLES - The present invention relates to a dishwashing composition comprising abrasive particles and a suspending aid selected from the group consisting of crystalline wax structurants, micro-fibril-cellulose, amido-gellants, di-benzylidene polyol acetal derivatives, and mixtures thereof, and the process and use thereof. | 2012-03-22 |
20120071384 | LAUNDRY COMPOSITION FOR TREATMENT OF SUNSCREEN STAINS BASED ON EXTENDED CHAIN SURFACTANTS - The invention discloses synergistic combinations of surfactants blends and cleaning composition. In certain embodiments a surfactant system is disclosed which includes extended anionic surfactants, linker surfactants, and a multiply charged cation component. This system forms emulsions with, and can remove greasy and oily stains, even those comprised of non-trans fats. In another embodiment anionic surfactants are combined with a solvent, and amine oxide to remove sunscreen stains. The compositions may be used alone, as a pre-spotter or other pre-treatment or as a part of a soft surface or hard surface cleaning composition. | 2012-03-22 |
20120071385 | QUATERNARY FUNCTIONALIZED ALKYL POLYGLUCOSIDES FOR ENHANCED FOOD SOIL REMOVAL - A cleaning composition including a primarily C | 2012-03-22 |
20120071386 | POLY QUATERNARY FUNCTIONALIZED ALKYL POLYGLUCOSIDES FOR ENHANCED FOOD SOIL REMOVAL - A cleaning composition including a poly quaternary functionalized alkyl polyglucoside, a water conditioning agent, an acid source, a solvent, and water. In one embodiment, the cleaning composition is substantially free of alkyl phenol ethoxylates. The cleaning composition is capable of removing soils including up to 20% proteins. The cleaning compositions include a biorenewable, environmentally friendly alternative to nonyl phenol ethoxylates and exhibit superior cleaning of food soils. | 2012-03-22 |
20120071387 | Soap Saver - A soap saver comprises an original soap bar and a soap fragment. The original soap bar comprises a cavity. The cavity comprises a predetermined shape, a cavity wall, and a cavity bottom surface. The cavity wall will be a continuous wall and will be connected to the cavity bottom surface. The cavity wall will have a smooth surface around the wall. The cavity bottom surface will not be a smooth surface. The soap fragment will be inserted into the cavity so the soap fragment can be reused with the original soap bar. Water will combined both the soap fragment and the original soap bar together. | 2012-03-22 |
20120071388 | POLY SULFONATE FUNCTIONALIZED ALKYL POLYGLUCOSIDES FOR ENHANCED FOOD SOIL REMOVAL - A cleaning composition including a primarily C | 2012-03-22 |
20120071389 | BETAINE FUNCTIONALIZED ALKYL POLYGLUCOSIDES FOR ENHANCED FOOD SOIL REMOVAL - A cleaning composition including a betaine functionalized alkyl polyglucoside, a water conditioning agent, an acid source, a solvent, and water. In one embodiment, the cleaning composition is substantially free of alkyl phenol ethoxylates. The cleaning composition is capable of removing soils including up to 20% proteins. The cleaning compositions include a biorenewable, environmentally friendly alternative to nonyl phenol ethoxylates and exhibit superior cleaning of food soils. | 2012-03-22 |
20120071390 | DETERGENT COMPOSITION CONTAINING BIO-DERIVED 1,3-PROPANEDIOL AND ITS CONJUGATE ESTERS - Biodegradable detergent compositions comprising 1,3-propanediol are provided, and the 1,3-propanediol in the composition is biologically derived. The compositions exhibit a lower anthropogenic CO | 2012-03-22 |
20120071391 | BENEFIT AGENT CONTAINING DELIVERY PARTICLE - The present invention relates to benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions. When employed in compositions, for example, cleaning or fabric care compositions, such particles increase the efficiency of benefit agent delivery, there by allowing reduced amounts of benefit agents to be employed. In addition to allowing the amount of benefit agent to be reduced, such particles allow a broad range of benefit agents to be employed. | 2012-03-22 |
20120071392 | BENEFIT AGENT CONTAINING DELIVERY PARTICLE - The present invention relates to benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions. When employed in compositions, for example, cleaning or fabric care compositions, such particles increase the efficiency of benefit agent delivery, there by allowing reduced amounts of benefit agents to be employed. In addition to allowing the amount of benefit agent to be reduced, such particles allow a broad range of benefit agents to be employed. | 2012-03-22 |
20120071393 | Mutant CyaA Polypeptides and Polypeptide Derivatives Suitable for the Delivery of Immunogenic Molecules Into a Cell - The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide derivatives suitable for eliciting an immune response in a host. | 2012-03-22 |
20120071394 | NOVEL POLYPEPTIDES AND USE THEREOF - The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of | 2012-03-22 |
20120071395 | TREATMENT OF MAMMALIAN PHYSIOLOGICAL REACTION OF IgE ANTIBODIES PRESENT IN SAID MAMMAL UPON CONTACT WITH THE CORRESPONDEING ANTIGEN - A method is disclosed for blocking or reducing physiological reaction in a mammal to the interaction of IgE antibodies present in said mammal upon contact with the corresponding antigen, by the administration to said mammal of a therapeutically effective amount of a neurotoxin (CnT) derived from Clostridia sp. | 2012-03-22 |
20120071396 | Compositions and Methods for Inhibiting the Interaction Between CFTR and CAL - The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface. | 2012-03-22 |
20120071397 | Methods for Hematopoietic Stem Cell Transplantation - The present invention provides methods for treating a subject undergoing hematopoietic stem cell transplantation, methods for increasing a subject's resistance to bacterial or viral infection during and/or following hematopoietic stem cell transplantation, and methods for treating norovirus infection. | 2012-03-22 |
20120071398 | ANTI-MICROBIAL PEPTIDES - The present invention relates to peptides comprising amino acids according to Formula I | 2012-03-22 |
20120071399 | SULFATION OF WNT PATHWAY PROTEINS - Provided is a composition comprising a peptide comprising amino acids and/or amino acid analogs comprising a continuous sequence of a sclerostin fragment comprising Tyr43 or Tyr213. Also provided is a composition comprising a peptide comprising less than about 75 amino acids and/or amino acid analogs including an amino acid or amino acid analog capable of being sulfated, where the composition is capable of inhibiting sclerostin binding to an LRP. Further provided is a composition comprising a peptide comprising less than about 75 amino acids and/or amino acid analogs including an amino acid or amino acid analog capable of being post-translationally sulfated, where the composition is capable of inhibiting binding of a protein ligand comprising a sulfation site to its binding partner. Additionally provided is a method of enhancing a Wnt signaling pathway comprising contacting an LRP5/6 receptor in the Wnt signaling pathway with either of the above-described compositions that comprise a sequence of a sclerostin fragment or is capable of inhibiting sclerostin binding to an LRP, where the tyrosine or tyrosine analog is not sulfated, in a manner sufficient to enhance the Wnt signaling pathway. Further provided is a method of treating a subject having a disease exacerbated by inhibition of a Wnt signaling pathway comprising administering either of the above-described compositions that comprise a sequence of a sclerostin fragment or is capable of inhibiting sclerostin binding to an LRP, where the tyrosine or tyrosine analog is not sulfated, to the subject in a manner sufficient to reduce the inhibition of the Wnt signaling pathway. Also, a method of inhibiting binding of a protein ligand comprising a sulfation site to its binding partner is provided. The method comprises adding the above-described composition that is capable of inhibiting binding of a protein ligand to its binding partner to the protein ligand and its binding partner in a manner sufficient to inhibit binding of the protein ligand to its binding partner. | 2012-03-22 |
20120071400 | LIPID METABOLISM-IMPROVING REAGENT - Our objective is to provide a novel lipid metabolism-improving reagent effective in preventing and treating hyperlipidemia and obesity and to provide this reagent in food, beverages, nutritional supplements, and fodders with the ability to improve lipid metabolism. The whey protein hydrolysate as the active ingredient in the lipid metabolism-improving reagent has a molecular weight distribution of 10 kDa or less, with the main peak between 200 Da to 3 kDa, average peptide chain length (APL) of 2-8, free amino acid content of 20% or less, antigenicity of 1/10,000 or less compared with that of β-lactoglobulin. | 2012-03-22 |
20120071401 | AMYLIN AGONIST COMPOUNDS FOR ESTROGEN-DEFICIENT MAMMALS - Provided herein are methods to treat estrogen deficiency in mammals by administering amylin agonist compounds. Also provided herein are methods to treat obesity and overweight in estrogen-deficient mammals; methods to reduce or maintain body weight and/or body fat in estrogen-deficient mammals; and methods to increase Bdnf levels in mammals by administering effective amounts of amylin agonist compounds. The estrogen deficiency may be caused by menopause, perimenopause, post-menopause, ovarian dysfunction, an overectomy, a hysterectomy, and the like. The amylin agonist compounds may be any known in the art or described herein, such as pramlintide, davalintide, or SEQ ID NO: 142. | 2012-03-22 |
20120071402 | Protease Stabilized, Pegylated Insulin Analogues - Novel PEGylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain B25H and A14E or A14H. The PEGylation is at B29K. | 2012-03-22 |
20120071403 | Methods for Treating Type 2 Diabetes in Patients Resistant to Previous Treatment with other Anti-Diabetic Drugs Employing an SGLT2 Inhibitor and Compositions Thereof - The invention provides methods for treating a patient having type 2 diabetes who has failed on previous regimens of one or more oral and/or injectable anti-diabetic agents, which include the step of administering a therapeutically effective amount of an SGLT2 inhibitor alone or in combination with another anti-diabetic agent and/or other therapeutic agent to such patient. A pharmaceutical composition containing dapagliflozin or dapagliflozin-S-propylene glycol solvate and one or more diabetic agents and/or other therapeutic agents for use in the methods of the invention is also provided. | 2012-03-22 |
20120071404 | STIMULATION OF PROLIFERATION OF PLURIPOTENTIAL STEM CELLS THROUGH ADMINISTRATION OF PREGNANCY ASSOCIATED COMPOUNDS - The present invention provides for a method for stimulating the proliferation of pluripotential stem cells in a mammal comprising administration of pregnancy related compounds more particularly human chorionic gonadotropin, leutenizing hormone or prolactin. The present invention further provides for a method of treatment of tissues or organs experiencing cellular damage, injury or disease. | 2012-03-22 |
20120071405 | COMPOSITION OF INHIBITING PATHOLOGICAL ANGIOGENESIS - The present invention provides a pharmaceutical composition for inhibiting pathologic angiogenesis and/or cell proliferative disorder. The pharmaceutical composition of the present invention comprises an effective amount of LECT2 protein or analogue thereof, and a pharmaceutically acceptable carrier. | 2012-03-22 |
20120071406 | MODIFIED VEGF-A WITH IMPROVED ANGIOGENIC PROPERTIES - The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A. | 2012-03-22 |
20120071407 | METHOD OF TREATING WOUNDS - A novel method of treating a wound is provided. The method comprises administering a therapeutically effective amount of periostin to the wound. | 2012-03-22 |
20120071408 | FORMULATIONS FOR ACHIEVING WEIGHT LOSS - A formulation of human chorionic gonadotropin (HCG) for promoting weight loss comprising reconstituted HCG in an amount sufficient to promote weight loss; at least one vitamin selected from the group consisting of: vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin B9, and vitamin B12; and at least one dietary supplement selected from the group consisting of: an amino acid, inositol, choline chloride, and L-carnitine. | 2012-03-22 |
20120071409 | Colloidal Liposomal Compositions and Methods - A formulation delivery system is disclosed. When configured as a pro-liposome oral tablet, the tablet comprises a blend of at least one Iiposome forming ingredient, at least one active ingredient and at least one co-disintegrant. After ingestion at least a portion of the tablet disintegrates in a portion of an alimentary system to provide one or more in situ Iiposome encapsulated active ingredients. A method of producing the pro-liposome oral tablet and a method of therapeutically dosing with the pro-liposome oral tablet are further disclosed. The formulation delivery system may be configured as any one of a pro-liposome oral tablet, sublingual tablet, caplet, capsule and aerosol. | 2012-03-22 |
20120071410 | CALCITONIN PRODUCTS AND THERAPIES FOR TREATING INFLAMMATORY OR DEGENERATIVE DISEASES - Calcitonin products and therapies for treating inflammatory or degenerative diseases are disclosed herein. The pharmaceutical compositions disclosed herein include a first therapeutic agent that is calcitonin, in free or salt form; a second therapeutic agent selected from the group consisting of a protease inhibitor, an antibiotic, a non-steroidal anti-inflammatory agent, a COX-2 inhibitor and a steroidal anti-inflammatory agent other than glucocorticoid; and a pharmaceutically acceptable excipient, carrier or diluent. The methods disclosed herein for treating inflammatory or degenerative diseases in a subject include administering a therapeutically effective amount of calcitonin, in free or salt form, to the subject; and co-administering, as part of a combination therapy, a therapeutically effective amount of a second therapeutic agent selected from the group consisting of a protease inhibitor, an antibiotic, a non-steroidal anti-inflammatory agent, a COX-2 inhibitor and a steroidal anti-inflammatory agent other than glucocorticoid to the subject. | 2012-03-22 |
20120071411 | LKKTET AND/OR LKKTNT PEPTIDE COMPOSITIONS WHICH ARE LYOPHILIZED OR IN A FORM CAPABLE OF BEING LYOPHILIZED - A composition including a peptide agent including amino acid sequence LKKTET [SEQ ID NO: 1] or LKKTNT [SEQ ID NO: 2], a conservative variant thereof, or a stimulating agent that stimulates production of an LKKTET [SEQ ID NO: 1] or LKKTNT [SEQ ID NO: 2] peptide, or a conservative variant thereof, the composition including at least one amino acid stabilizing agent or lyophilization bulking agent, the composition being in lyophilized form, or in a form capable of being lyophilized. | 2012-03-22 |
20120071412 | METHODS OF USING MACROCYCLIC AGONISTS OF THE GHRELIN RECEPTOR FOR TREATMENT OF GASTROINTESTINAL MOTILITY DISORDERS - The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective agonists of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Such compounds are useful as medicaments for treatment and prevention of a range of medical conditions characterized by disturbed gastrointestinal motility including, but not limited to, post-surgical gastroparesis and post-operative ileus in combination with opioid-induced bowel dysfunction. These agents are effective for multiple disorders at dose levels equivalent to those required to treat a single disorder. | 2012-03-22 |
20120071413 | TREATMENT OF CHRONIC NEPHROPATHIES USING SOLUBLE COMPLEMENT RECEPTOR TYPE I (sCR1) - A method is disclosed for treating nephropathies involving undesired alternative pathway complement activation by administration of a complement inhibitory protein such as soluble complement receptor type I (sCR1). | 2012-03-22 |