12th week of 2014 patent applcation highlights part 46 |
Patent application number | Title | Published |
20140080144 | METHOD FOR DETERMINING PLATELET-ASSOCIATED ANALYTES - The present invention relates to a routine in vitro method for determining platelet-associated analytes, for example VWF, factor XIII, fibrinogen or D-dimer, in a sample of platelet-rich plasma. | 2014-03-20 |
20140080145 | Monomeric and Polymeric Linkers Useful For Conjugating Biological Molecules and Other Substances - The present invention concerns monomeric or polymeric linker molecules useful in biological and chemical applications, their synthesis, and the synthesis and use of derivatives of the linkers conjugated to a variety of detectable labels and other substances. The linkers may be used, for example, in conjunction with fluorescent labels, nucleic acid or nucleic acid analog probes, and solid phase systems, and to enhance the solubility of the conjugated molecules. | 2014-03-20 |
20140080146 | METHOD FOR DETECTING NEUROLOGICAL DISEASE ASSOCIATED WITH COGNITIVE IMPAIRMENT BY MEASURING EPHA4 EXTRACELLULAR DOMAIN - A method for detecting a neurological disease associated with cognitive impairment, wherein the extracellular domain of EphA4 is measured from a biological sample taken from a subject. | 2014-03-20 |
20140080147 | NOVEL CD3 EPSILON IMMUNOGENS AND ANTIBODIES - The present invention relates to novel CD3 epsilon peptides, antibodies against the novel CD3 epsilon peptides. The invention also relates to methods of identifying an immunodeficiency (such as severe combined immunodeficiency (SCID) or a T cell immunodeficiency) in a patient, which may involve antibodies against CD3 epsilon peptides. | 2014-03-20 |
20140080148 | Generation of NK Cells and NK-Cell Progenitors - The present invention provides a cytokine-based culture method for ex vivo expansion of NK cells from postembryonic hematopoietic stem cells into a fully closed, large-scale, cell culture bioprocess. We optimized enrichment of CD34 | 2014-03-20 |
20140080149 | Method and Arrangement for Quantifying Subgroups from a Mixed Population of Cells - A method for determining the mass and concentration of certain particles or cells from a mixed population of cells, such as a patient's blood sample. The cells to be determined are each marked with a monoclonal antibody, to which colloidal iron is coupled. The blood sample is filled into a test tube with a capillary section and a magnet is used to gather the marked cells and move them to the capillary section. A test tube rack is constructed to hold the test tube with the capillary section and a measurement scale is provided for determining the mass and concentration of the marked cells. | 2014-03-20 |
20140080150 | METHOD AND KIT FOR RAPID ISOLATION OF HUMAN FOXP3+ TREG CELLS - The present invention relates to methods for isolating human forkhead box P3 (Foxp3+) CD4+ regulatory T cells (herein referred to a Foxp3+ Treg cells) from a sample containing (i) peripheral blood mononuclear cells (PBMCs), (ii) a lymphocyte containing fluid, or (iii) a lymphocyte containing tissue, a kit for isolating human Foxp3+ Treg cells, and the use of anti-CD49d antibody for the isolation of human Foxp3+ Treg cells. | 2014-03-20 |
20140080151 | ANTI-HIMF ANTIBODIES TO TREAT LUNG DISEASES - Hypoxia induced mitogenic factor (HIMF) is a member of the “found in inflammatory zone” (FIZZ)/resistin family of proteins and has potent mitogenic, angiogenic, and vasoconstrictive effects in the lung vasculature. The receptor/binding partners for this family of proteins have been largely unknown. We identified Bruton's tyrosine kinase (BTK) as a functional HIMF binding partner through GST-HIMF pull-downs and mass spectrometry. Using primary cultured HIMF-stimulated murine bone marrow cells, we demonstrated that BTK was recruited to the leading edge of the cells. A transwell migration assay showed that treatment with recombinant murine HIMF induced migration of primary cultured bone marrow cells, which was completely blocked by a BTK inhibitor. In vivo studies revealed that HIMF can stimulate angiogenesis in the hypoxic tissue. Our results indicate that HIMF may act as a chemotactic molecule in stimulating the migration of leukocytes/EPCs from bone marrow to targeted tissues through activation of the BTK pathway. | 2014-03-20 |
20140080152 | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR - The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. | 2014-03-20 |
20140080153 | METHOD FOR IMPROVING PHYSICAL PROPERTIES OF ANTIBODY - The present inventors discovered that physicochemical properties of a polypeptide can be improved by reducing the extracellular matrix-binding activity of the polypeptide. | 2014-03-20 |
20140080154 | IMMUNODIAGNOSTIC METHOD FOR DIAGNOSING AUTO-IMMUNE SYSTEMIC SCLEROSIS (SSC) AND SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) - The invention relates to a method for the identification of patients affected by Systemic Sclerosis (SSc) (early, limited cutaneous, diffuse forms) or Systemic Lupus Erythematosus (SLE). Among SSc and SLE patients, this method allows identification of presence of vascular ulcerations in SSc, and Raynaud's phenomenon in SLE, respectively. | 2014-03-20 |
20140080155 | DETECTION OF NGAL IN CHRONIC RENAL DISEASE - Methods of assessing the ongoing kidney status in a subject afflicted with chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in fluid samples over time. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine and serum as a result of chronic renal tubule cell injury. Incremental increases in NGAL levels in CRF patients over a prolonged period of time are diagnostic of worsening kidney disease. This increase in NGAL precedes and correlates with other indicators of worsening CRF, such as increased serum creatinine, increased urine protein secretion, and lower glomerular filtration rate (GFR). Proper detection of worsening (or improving, if treatment has been instituted) renal status over time, confirmed by pre- and post-treatment NGAL levels in the patient, can aid in designing and/or maintaining a proper treatment regimen to slow or stop the progression of CRF. | 2014-03-20 |
20140080156 | MEANS AND METHODS FOR DIAGNOSING AND TREATING MULTIPLE SCLEROSIS - This invention relates to a peptide comprising or consisting of at least 8 consecutive amino acid residues of the sequence set forth in SEQ ID NO: 3, provided that said peptide does not consist of the sequence set forth in SEQ ID NO: 3, or a corresponding peptidomimetic, wherein said peptide or peptidomimetic binds to an anti-KIR4.1 antibody comprised in a sample from a patient, said patient having multiple sclerosis or a predisposition therefor, wherein preferably (i) said at least 8 consecutive amino acid residues are a subsequence of an extracellular domain of KIR4.1, said extracellular domain consisting of the sequence set forth in SEQ ID NO: 1 or 2; or (ii) said peptide comprises or consists of the sequence of SEQ ID NO: 1 or 2. The present invention furthermore relates to a method for diagnosing multiple sclerosis or a predisposition for multiple sclerosis in a subject, the method comprising determining the presence of an anti-KIR4.1 antibody in a sample obtained from said subject, wherein the presence of an anti-KIR4.1 antibody in said sample is indicative of multiple sclerosis or a predisposition for multiple sclerosis. Also provided are novel means and methods for the therapy of multiple sclerosis. | 2014-03-20 |
20140080157 | MATERNAL BIOMARKERS FOR GESTATIONAL DIABETES - Embodiments herein relate to the field of screening tools for fetal/maternal wellness, and, more specifically, to biomarkers for gestational diabetes. In various embodiments, the methods may provide non-invasive and minimally-invasive screening tools for gestational diabetes that involve detection of changes in a proteomic profile of a test sample relative to a reference sample. In particular embodiments, the method may include determining whether a proteomic profile of a test sample from the subject includes at least one expression signature characteristic of gestational diabetes, wherein the proteomic profile comprises information on the expression of glycosylated fibronectin and glycosylated PSG, for example information on levels of fibronectin-SNA or a fibronectin-antibody complex, and PSG-AAL or a PSG-antibody complex. In some embodiments, the proteomic profile may also include information on the expression of adiponectin, sex hormone binding globulin (SHBG), C-reactive protein (CRP), a ratio of human chorionic gonadotropin (hCG) to placental lactogen, or a combination thereof. | 2014-03-20 |
20140080158 | METHOD FOR IMMUNOLOGICALLY MEASURING SOLUBLE LR11 - To provide a method for assaying soluble LR11 in a biological sample, which method realizes a simple and accurate assay of soluble LR11 present in the sample by immunological means without requiring isolation of soluble LR11 from the biological sample (e.g., a serum sample). | 2014-03-20 |
20140080159 | LIGHT COLLECTION SYSTEM - The present teachings provide a detection cell for a biological material and methods for detecting biological material including a photosensitive material optically coupled to an interior volume containing the biological material so to avoid optical components or an external light source. | 2014-03-20 |
20140080160 | Assessment of Protein C Anticoagulant Pathway By Thrombin Generation Assay In The Presence of Endothelial Cells - The present application discloses the effects of endothelial cell-dependent activation of the protein C anticoagulant pathway via detection of thrombin generation correlated with the activation of the protein C anticoagulant pathway in plasma in the presence of endothelial cells using a fluorogenic substrate-based thrombin generation assay. | 2014-03-20 |
20140080161 | PHOSPHATASE COUPLED KINASE ASSAY - Assays and methods for detecting and quantifying the activity of a test kinase. The assay includes a nucleotide phosphatase at least ten times more active on ADP than on ATP and a free phosphate detector. The assay may also include a control kinase and/or ATP. Methods of the invention include combining a test kinase, a substrate of the test kinase, and a known quantity of ATP under conditions to produce ADP, combining the produced ADP with a phosphatase specific for ADP, and measuring free phosphate. The amount of phosphate produced directly correlates to the activity of the kinase.phosphatase coupled kinase assay | 2014-03-20 |
20140080162 | FLUORESCENCE LIFETIME EPIGENETICS ASSAYS - The invention is concerned with methods of assaying the activity of enzymes based on measurement of fluorescence lifetime (FLT). In particular, the invention relates to assays for enzymes which are capable of modifying the structure of peptide substrates, including for example enzymes catalysing methylation, demethylation, acetylation, deacetylation or deimination of peptide substrates. | 2014-03-20 |
20140080163 | LUMINESCENT PROBES HAVING A PHENANTHRIDINYL ANTENNA, AND METHODS OF USE - A molecular probe for the luminescent detection of nucleotides (e.g., adenosine nucleotides) is presented. In certain embodiments, the probe can readily distinguish between the three adenosine nucleotides in buffered aqueous conditions at neutral pH, a need for the direct monitoring of enzymatic reactions converting ATP to ADP or AMP. The probe is most efficient under millimolar concentrations of ATP, which are relevant to intracellular conditions. In preferred embodiments, the long luminescence lifetime of the probe readily enables time-gating experiments. | 2014-03-20 |
20140080164 | METHODS AND COMPOSITIONS FOR THE DETECTION OF BETA-LACTAMASES - Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10 minutes. | 2014-03-20 |
20140080165 | METHODS AND APPARATUS FOR SELECTIVELY PROCESSING EGGS HAVING IDENTIFIED CHARACTERISTICS - Methods and apparatus for processing eggs based upon a characteristic such as gender are provided. Material is extracted from each of a plurality of live eggs, the extracted material is assayed to identify eggs having the characteristic, and then eggs identified as having the characteristic are processed accordingly. | 2014-03-20 |
20140080166 | Method for the Early Detection of Renal Disease Using Proteomics - A method for the detection of an early biomarker for assessing a change in renal status in a mammalian subject following a renal event. The method typically includes the steps of (a) providing a body fluid sample obtained from a mammalian subject; (b) analyzing the molecular weight of the proteins in the sample using proteome analysis; and (c) identifying the presence of a protein in the sample selected from the group consisting of a 6.4 kDa protein, a 28.5 kDa protein, a 33 kDa protein, a 44 kDa protein, a 67 kDa protein, and combinations thereof. The presence of one of these proteins can serve as an early biomarker for assessing a change in renal status. The levels of these proteins can be compared to predetermined levels, and thus provide a determination of the subject's renal status. The invention also includes a method of assessing the administration of aprotinin during cardio-pulmonary bypass surgery and provides for methods where the level of the 6.4 kDa biomarker in the subject's urine directs a caregiver's therapeutic decision regarding the intra-operative administration of aprotinin. | 2014-03-20 |
20140080167 | Biosensor Calibration Method - A biosensor calibration method configured to measure a concentration of a specific substance contained in sample liquid to be measured, including: a first step configured to acquire a first output value that is output by the biosensor when first calibration liquid is brought into contact with the biosensor; a second step configured to acquire a second output value that is output by the biosensor when second calibration liquid having a different concentration from that of the first calibration liquid is continuously brought into contact with the biosensor after the first step and determine time for replacement of the biosensor on the basis of the first output value and the second output value. | 2014-03-20 |
20140080168 | CLASS OF NEAR INFRARED OPTICAL PROBES FOR BIOLOGICAL APPLICATIONS - 2,5-Bis(benzoxazol-2′-yl)benzene-1,4-diol derivatives (Zinhbo derivatives) are used to detect zinc ions and have particular application in vivo and in vitro. Zinhbo derivatives upon excitation give a florescence response emission that can be used to determine the presence of zinc cation in solution. Zinhbo derivatives complexed with zinc cations upon excitation can produce a florescence response emission in the visible and near infrared range. Zinhbo derivatives complexed with zinc cations exhibit a large stoke shift between the excitation and emission wavelengths. | 2014-03-20 |
20140080169 | PROCESS TO AVOID INHIBITION OF ACETOGENS BY CO - A process is provided for fermenting CO-containing gaseous substrates. The process is effective for decreasing lag times and maintaining a culture in steady state by controlling CO concentration and minimizing effects of high or low CO concentrations during fermentation. The process includes providing syngas to a first fermentation zone, fermenting the syngas, and determining a CO concentration in a fermentation medium in the first fermentation zone. If the CO concentration in fermentation medium in the first fermentation zone has a calculated value of about 0.12 mM or greater, then at least a portion of the syngas being provided to the first fermentation zone is provided to one or more subsequent fermentation zones in an amount effective for providing a calculated CO concentration in any subsequent fermentation zone of about 0.12 mM or less. | 2014-03-20 |
20140080170 | FLUORESCENT ION INDICATORS AND THEIR APPLICATIONS - Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations. | 2014-03-20 |
20140080171 | OPTICAL CYTOMETRY - The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques. | 2014-03-20 |
20140080172 | Systems and Methods for Monitoring Chemical Processes - Disclosed are systems and methods for monitoring chemical reaction processes in or near real-time. One method may include containing a fluid within a flow path, the fluid having a chemical reaction occurring therein, optically interacting at least one integrated computational element with the fluid, thereby generating optically interacted light, and producing an output signal based on the optically interacted light that corresponds to a characteristic of the chemical reaction. | 2014-03-20 |
20140080173 | PRODUCTION OF AN ASPERGILLUS CONTAMINATION IMPRINT BASED ON DETECTION OF MVOC - This invention proposes a method comprising the steps of: | 2014-03-20 |
20140080174 | SUBSTRATE-SHEET FABRICATING METHOD - A group of small pieces of divided base substrate is arrayed on a sheet without gaps therebetween by means of a simple method. Provided is a substrate-sheet fabricating method including cutting into a group of small pieces a base substrate whose first-side surface is attached to a first sheet member; transferring the group of small pieces to a second sheet member by attaching the second sheet member, which can be contracted in the direction along a surface thereof, to second-side surfaces of the group of small pieces and by peeling off the first sheet member from the first-side surfaces of the group of small pieces; and making the second sheet member contract in the direction along the surface thereof. | 2014-03-20 |
20140080175 | PROCESSES FOR PREPARING TUBULYSIN DERIVATIVES AND CONJUGATES THEREOF - The invention described herein pertains to processes for preparing tubulysin derivatives, conjugates of tubulysins, and intermediates therefore. | 2014-03-20 |
20140080176 | TRANSFORMABLE RHODOBACTER STRAINS, METHOD FOR PRODUCING TRANSFORMABLE RHODOBACTER STRAINS - The invention provides an organism for expressing foreign DNA, the organism engineered to accept standard DNA carriers. The genome of the organism codes for intracytoplasmic membranes and features an interruption in at least one of the genes coding for restriction enzymes. Further provided is a system for producing biological materials comprising: selecting a vehicle to carry DNA which codes for the biological materials; determining sites on the vehicle's DNA sequence susceptible to restriction enzyme cleavage; choosing an organism to accept the vehicle based on that organism not acting upon at least one of said vehicle's sites; engineering said vehicle to contain said DNA; thereby creating a synthetic vector; and causing the synthetic vector to enter the organism so as cause expression of said DNA. | 2014-03-20 |
20140080177 | ANTICALINS - The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using generic engineering methods. Alike immunoglobulin, the anticalin thus obtained can be used to identify or bond molecular structures. | 2014-03-20 |
20140080178 | Polypeptides Having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2014-03-20 |
20140080179 | PROCESS FOR PRODUCING PROTEIN A-LIKE PROTEIN WITH USE OF BREVIBACILLUS GENUS BACTERIUM - The present invention relates to an efficient and economical process for producing a protein A-like protein. Hosts such as | 2014-03-20 |
20140080180 | HARVEST OPERATIONS FOR RECOMBINANT PROTEINS - The present invention contemplates methods of producing a recombinant protein comprising fermenting a prokaryotic host cell wherein said prokaryotic host cell has been transformed with a nucleic acid encoding said recombinant protein, harvesting said recombinant protein under conditions where dO | 2014-03-20 |
20140080181 | POLYNUCLEOTIDES ENCODING IL-31 MONOCLONAL ANTIBODIES - The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention further provides the hybridomas that generate the monoclonal antibodies. | 2014-03-20 |
20140080182 | Cellulose Binding Domain Variants and Polynucleotides Encoding Same - The present invention relates to cellobiohydrolase variants and cellulose binding domain variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 2014-03-20 |
20140080183 | HYBRID SEPARATION - This disclosure describes techniques for using a single feedstock of barley to produce a fermented product and a method for filtering a large-particles stream from a liquid stream containing small particles of a process stream using a series of mechanical separation devices to increase yield. | 2014-03-20 |
20140080184 | NOVEL ISOLATED BACTERIAL STRAIN OF GLUCONACETOBACTER OBOEDIENS AND AN OPTIMIZED ECONOMIC PROCESS FOR MICROBIAL CELLULOSE PRODUCTION THEREFROM - The present invention provides a novel and potent cellulose producing bacterial species, | 2014-03-20 |
20140080185 | Method for Producing a Target Substance by Fermentation - A method is described for producing a target substance utilizing a microorganism by culturing the microorganism in a medium to produce and accumulate the target substance in the medium, and then collecting the target substance from culture. The microorganism is imparted with isomaltase activity, or modified to increase isomaltase activity. | 2014-03-20 |
20140080186 | METHOD FOR PRODUCING L-CYSTINE BY FERMENTATION UNDER CONTROLLED OXYGEN SATURATION - The invention relates to a method for producing L-cystine by fermenting a microorganism strain in a fermentation medium, in which method L-cystine is precipitated in an amount of at least 70% relative to the total cysteine, characterized in that the O | 2014-03-20 |
20140080187 | SERINOL PRODUCTION IN GLYCEROL CATABOLISM DEFICIENT ESCHERICHIA COLI STRAINS - The invention is about | 2014-03-20 |
20140080188 | YEAST MICROORGANISMS WITH REDUCED 2,3-BUTANEDIOL ACCUMULATION FOR IMPROVED PRODUCTION OF FUELS, CHEMICALS, AND AMINO ACIDS - The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of an acetolactate-derived by-product such as 2,3-butanediol. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the | 2014-03-20 |
20140080189 | Method for Producing Butanol using Extractive Fermentation with Electrolyte Addition - A method for producing butanol through microbial fermentation, in which the butanol product is removed during the fermentation by extraction into a water-immiscible organic extractant in the presence of at least one electrolyte at a concentration at least sufficient to increase the butanol partition coefficient relative to that in the presence of the salt concentration of the basal fermentation medium, is provided. The electrolyte may comprise a salt which dissociates in the fermentation medium, or in the aqueous phase of a biphasic fermentation medium, to form free ions. Also provided is a method and composition for recovering butanol from a fermentation medium. | 2014-03-20 |
20140080190 | SPORULATION-DEFICIENT THERMOPHILIC MICROORGANISMS FOR THE PRODUCTION OF ETHANOL - A thermophilic microorganism comprising a modification that prevents sporulation, wherein the modification inactivates the native spo0A gene | 2014-03-20 |
20140080191 | APPARATUS AND PROCESS FOR FERMENTATION OF BIOMASS HYDROLYSATE - A process for converting biomass hydrolysate into biofuel, the process comprising the steps of: obtaining a biomass hydrolysate solution comprising monosaccharides; immobilizing | 2014-03-20 |
20140080192 | Genetically Modified Yeast Species, and Fermentation Processes Using Genetically Modified Yeast - Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase. | 2014-03-20 |
20140080193 | Methods For Enhancing The Degradation Or Conversion Of Cellulosic Material - The present invention relates to methods for degrading or converting a cellulosic material and for producing a substance from a cellulosic material. | 2014-03-20 |
20140080194 | Alpha-amylase variant with altered properties - The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase. | 2014-03-20 |
20140080195 | PROCESS FOR REDUCING CO2 EMISSIONS AND INCREASING ALCOHOL PRODUCTIVITY IN SYNGAS FERMENTATION - A process is provided that is effective for reducing CO | 2014-03-20 |
20140080196 | METHOD FOR THE COMPLETE ANAEROBIC DIGESTION OF POLYMER MIXTURES - The present invention relates to a process for complete anaerobic digestion of polymer mixtures of the composition:
| 2014-03-20 |
20140080197 | NANOSTRUCTURED CARBON BASED BIOCATALYST FOR REMEDIATION OF ENVIRONMENTAL POLLUTANTS - The present invention provides a series of new and improved compounds/materials as vehicles to delivery degradative enzymes to remove/remedy environmental pollutants. The inventive material comprises a series of amide-functionalized ordered mesoporous carbon (AFOMC), which utilizes chemical conjugation techniques for the tethering of enzymes to the surface of the synthesized AFOMC. The delivery mechanism may be utilized to express a wide variety of toxin-degrading enzymes for removal/remediation of organic pollutants. | 2014-03-20 |
20140080198 | MOLECULAR ZIPPER TWEEZERS AND SPRING DEVICES - Techniques, structures, devices and systems are disclosed for implementing molecular zipper tweezers and springs. In one aspect, a molecular device includes three molecular components including at least a passive side molecular component, a binding side molecular component and a target molecular component adapted to interact together as a zipper that separate two of the molecular components held together by molecular interaction forces. | 2014-03-20 |
20140080199 | LUCIFERASE DERIVED FROM LUCIDINA ACCENSA - An object of the invention is to provide a novel and useful luciferase. The luciferase according to the embodiments of the invention is derived from | 2014-03-20 |
20140080200 | METHODS OF PURIFYING POLYPEPTIDES - The present invention relates to improved processes for purifying polypeptides of interest by increasing the amount of a polypeptide of interest bound to an ion-exchange matrix relative to the amount of one or more impurities bound to the ion-exchange matrix. This effect is achieved by adding a chemical compound in the process which by also binding to the ion-exchange matrix due to a change that is opposite to the change of the ion-exchange matrix, reduces the binding of impurities more than the binding of the polypeptide of interest. | 2014-03-20 |
20140080201 | Biosynthesis of Human Milk Oligosaccharides in Engineered Bacteria - The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection. | 2014-03-20 |
20140080202 | Fabricated Panel - A self-supporting composite material is made with a shape conforming to the shape of an enclosure within which the composite material is incubated and molded. In on embodiment, a lid with at least one extrusion is placed over the enclosure to form a void in the final product corresponding to the extrusion. In another embodiment, a tool with extruded features is pressed into a face of the product in the enclosure to mold features into the finished product. | 2014-03-20 |
20140080203 | Analytical Cartridge with Fluid Flow Control - Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample. | 2014-03-20 |
20140080204 | Apparatus for the Rapid Diagnosis of Targets in Human Body Fluids - More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member. | 2014-03-20 |
20140080205 | SYSTEM OR DEVICE FOR BIOCHEMICAL ANALYSIS HAVING AT LEAST ONE ELECTROOSMOTIC PUMP - An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity. | 2014-03-20 |
20140080206 | MICROFLUIDIC SYSTEM FOR CONTROLLING A CONCENTRATION PROFILE OF MOLECULES CAPABLE OF STIMULATING A TARGET - The invention relates to a microfluidic system for controlling a concentration profile of molecules capable of stimulating a target, for example formed by an assembly of living cells, this system comprising: -a microfluidic device ( | 2014-03-20 |
20140080207 | ULTRASOUND AND ACOUSTOPHORESIS FOR COLLECTION AND PROCESSING OF OLEAGINOUS MICROORGANISMS - Microorganisms such as microalgae are collected and separated from a host medium such as water. Cellular walls and membranes of the microorganisms are then ruptured to release their lipids using a lipid extraction unit. Thereafter, the lipids from the host medium are collected and separated using a lipid collection and separation unit. Related apparatus, systems, techniques and articles are also described. | 2014-03-20 |
20140080208 | ADENOVIRAL VECTOR VACCINE - Provided are adenoviral vectors for generating an immune response to antigen. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal sequence upstream of a tumor antigen upstream of CD40 ligand, which is missing all or substantially all of the transmembrane domain rendering CD40L secretable. Also provided are methods of generating an immune response against cells expressing a tumor antigen by administering an effective amount of the invention vector. Further provided are methods of generating an immune response against cancer expressing a tumor antigen in an individual by administering an effective amount of the invention vector. Still further provided are methods of generating immunity to infection by human papilloma virus (HPV) by administering an effective amount of the invention vector which encodes the E6 or E7 protein of HPV. The immunity generated is long term. | 2014-03-20 |
20140080209 | METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION COMPRISING ADMINISTERING A TRIARYLMETHYL AMINE COMPOUND - This invention offers an effective method of inhibiting the expression of apolipoprotein E by mammalian cells. Apolipoprotein E is a protein that plays a significant role in the development of Alzheimer's Disease in humans. The method comprises administering an effective amount of a triarylmethyl amine compound having the general formula: | 2014-03-20 |
20140080210 | Treatment of Pluripotent Cells - The present invention is directed to methods to treat pluripotent cells, whereby the pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of GSK-3B enzyme activity. | 2014-03-20 |
20140080211 | MULTIWELL PLATE FOR REMOVING LIQUID AND CELL CULTURE METHOD USING THE SAME - Provided is a multiwell plate that includes first wells and second wells separated by a sidewall made of a porous material and a method of using the same. | 2014-03-20 |
20140080212 | BIOREACTOR SYSTEM FOR CONTINUOUS CELL CULTIVATION - A cell culture system for fermentation or cultivation of at least one of cells, tissues or tissue-like cell cultures, organs or organ-like cell cultures and multicellular organisms comprises:
| 2014-03-20 |
20140080213 | REACTOR - The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor. | 2014-03-20 |
20140080214 | CLEAVABLE CELLULOSIC SPONGE DEVELOPMENT FOR 3 DIMENSIONAL CELL CULTURE AND SPHEROIDS RETRIEVAL - A method of making a scaffold for 3 dimensional cell culture comprising the steps of conjugating a reducible disulfide bond onto a hydroxyl group at the side chain of a hydroxypropyl cellulose; forming a matrix of hydroxypropyl cellulose having the reducible disulfide bond conjugated onto the hydroxyl group such that a reducible disulfide bond exists adjacent to a double bond for crosslinking the matrix of hydroxypropyl cellulose. The scaffold and a system of using the scaffold for culturing 3 dimensional cell spheroids | 2014-03-20 |
20140080215 | BRANCHED POLYAMINES FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS - A branched polyamine comprises about 45 to about 70 backbone tertiary amine groups, about 90 to about 140 backbone secondary amine groups, a positive number n′ greater than 0 of backbone terminating primary amine groups, and a positive number q greater than 0 of backbone terminating carbamate groups of formula (2): | 2014-03-20 |
20140080216 | METHODS AND COMPOSITIONS FOR TREATMENT OF A GENETIC CONDITION - Methods and compositions for a genetic disease are provided. | 2014-03-20 |
20140080217 | Uranium Analysis Using Luminescence Enhancing Oxidant and Oxidant Composition - According to the present invention, there is provided a method of determining a concentration of uranium including: a) a primary measuring step of measuring luminescence intensity or luminescence attenuation of uranium (VI) of an oxidant added sample obtained by adding an oxidant composition to a detection target sample; b) a secondary measuring step of adding different volumes of standard solution containing uranium (VI) having a predetermined concentration to a plurality of oxidant added samples, respectively, and then measuring luminescence intensity or luminescence attenuation of uranium (VI) contained in each standard solution added sample; and c) a calculating step of calculating a concentration of uranium (VI) contained in the detection target sample by a standard addition method based on the primary and secondary measurements. With the method for determining a concentration of uranium according to the present invention, the concentration of uranium may be further rapidly and accurately analyzed. | 2014-03-20 |
20140080218 | METHODS OF EVALUATING PEPTIDE MIXTURES - The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture. | 2014-03-20 |
20140080219 | METHOD OF QUALIFYING MATERIAL FOR USE IN CLEANING OF ALKYLENE OXIDE EQUIPMENT - The present invention relates to methods for qualifying material for using in the cleaning of alkylene oxide equipment. Qualified material is not expected to contribute to the formation of determinable amounts of alkylene oxide by-products. Methods of cleaning alkylene oxide equipment, and alkylene oxide processes incorporating these methods are also provided. | 2014-03-20 |
20140080220 | Azide Substituted Naphthylene or Rylene Imide Derivatives and their Use as Reagents in Click-Reactions - Novel mono-azide substituted rylene-imide derivatives, their use in methods for the detection of analytes and reagents kits for the detection of analytes comprising said novel mono-azide substituted rylene-imide derivatives. | 2014-03-20 |
20140080221 | Semi-Continious Non-Methane Organic Carbon Analyzer - An instrument to provide on-site analyses utilizing a combination cryotrap and absorbent traps in the extraction of constituents from the sample gas stream consistent with the requirements of 40 CFR Pt. 60 App. A Method 25. | 2014-03-20 |
20140080222 | FLUORESCENT DYE FOR PH SENSOR - The present invention relates to a new type of fluorescent with the following formula (I), its preparation process, and also an optical pH sensor which comprises this fluorescent dye immobilized on an analyte-permeable carrier. | 2014-03-20 |
20140080223 | Systems and Methods for Inspecting and Monitoring a Pipeline - Disclosed are systems and methods for inspecting and monitoring an inner surface of a pipeline. One system includes a pig arranged within the pipeline and having first and second ends, one or more optical computing devices arranged on at least one of the first and second ends for monitoring a fluid within the pipeline. The optical computing devices including at least one integrated computational element configured to optically interact with the fluid and thereby generate optically interacted light, and at least one detector arranged to receive the optically interacted light and generate an output signal corresponding to a characteristic of the fluid. The system also includes a signal processor communicably coupled to the at least one detector of each optical computing device for receiving the output signal of each optical computing device and determining the characteristic of the fluid as detected by each optical computing device. | 2014-03-20 |
20140080224 | Systems and Methods for Inspecting and Monitoring a Pipeline - Disclosed are systems and methods for inspecting and monitoring an inner surface of a pipeline. One system includes a pig arranged within the pipeline and having a housing that defines a conduit therein for providing fluid communication through the pig, one or more optical computing devices arranged on the conduit for monitoring a bypass fluid flowing through the conduit. The one or more optical computing devices including at least one integrated computational element configured to optically interact with the bypass fluid and generate optically interacted light, and at least one detector arranged to receive the optically interacted light and generate an output signal corresponding to a characteristic of the bypass fluid. A signal processor is communicably coupled to the at least one detector of each optical computing device for receiving the corresponding output signals and determining the characteristic of the fluid. | 2014-03-20 |
20140080225 | METHODS AND DEVICES FOR XEROGEL BASED SENSORS - Fluorescence based sensing systems and methods that exploit xerogels are provided. Embodiments of the invention encompass a sensing system that includes: an optical excitation source emitting over a first predetermined wavelength range and capable of analog modulation over a predetermined frequency range; a sensor including a gel substrate incorporating within its matrix a receptor for molecular recognition of an analyte and a luminophore for signaling a recognition event relating to the analyte, the luminophore emitting an optical signal over a second predetermined wavelength range; a detection circuit including an optical detector for receiving the optical signal emitted by the luminophore and generating a photocurrent in dependence thereof; an excitation circuit that generates an analog signal for modulating the optical excitation source in dependence upon a digital control; and a read circuit for receiving the photocurrent and generating a digital output. | 2014-03-20 |
20140080226 | FLUID TRANSPORT SYSTEM WITH GASKET - Fluid transport system, including methods and apparatus, for moving fluid. The system may include a plurality of wells each having a rim. The system also may include a gasket defining a plurality of apertures that extend through the gasket from a top side to a bottom side of the gasket. The bottom side may define a plurality of grooves, with each groove extending at least partway around an axis defined by an aperture of the plurality of apertures. The gasket may be configured to have the top side of the gasket engaged with a pump assembly and at least a portion of the rim of each of the wells disposed in at least one groove of the plurality of grooves, to provide sealed communication between the pump assembly and each of the wells. | 2014-03-20 |
20140080227 | Method of Manufacturing Semiconductor Device - According to one embodiment, a method of manufacturing a semiconductor device includes forming a silicon nitride layer on a metal layer, forming a plasma of a gas mixture of carbon oxide and oxygen, and selectively etching the silicon nitride layer with respect to the metal layer by using the plasma of the gas mixture. | 2014-03-20 |
20140080228 | SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SEMICONDUCTOR DEVICE - A semiconductor device in which MRAM is formed in a wiring layer A contained in a multilayered wiring layer, the MRAM having at least two first magnetization pinning layers in contact with a first wiring formed in a wiring layer and insulated from each other, a free magnetization layer overlapping the two first magnetization pinning layers in a plan view, and connected with the first magnetization pinning layers, a non-magnetic layer situated over the free magnetization layer, and a second magnetization pinning layer situated over the non-magnetic layer. | 2014-03-20 |
20140080229 | ADAPTIVE SEMICONDUCTOR PROCESSING USING FEEDBACK FROM MEASUREMENT DEVICES - A semiconductor processing device and a method of operating the same. The method may include measuring at least one property of a semiconductor wafer and determining a recipe for processing the semiconductor wafer based on the at least one property. The semiconductor wafer may be processed with a plurality of chemical mechanical polishing (CMP) modules based on the determined recipe, wherein the recipe comprises a value of at least one parameter for use by each of the plurality of CMP modules. The measurements may be made in situ or by an inline metrology device. The recipe and various parameters associated with the recipe may be determined by a controller of the semiconductor processing device. | 2014-03-20 |
20140080230 | APPARATUS AND METHOD FOR EVALUATING OPTICAL PROPERTIES OF LED AND METHOD FOR MANUFACTURING LED DEVICE - An optical property evaluation apparatus includes: a light conversion filter converting light emitted from an LED chip or a bare LED package, which is to be evaluated, into a different wavelength of light, and emitting a specific color of light; and an optical property measurement unit receiving the specific color of light emitted from the light conversion filter and measuring the optical properties of the received light. | 2014-03-20 |
20140080231 | METHOD FOR MANUFACTURING LIGHT EMITTING ELEMENTS AND DEVICE FOR MANUFACTURING LIGHT EMITTING ELEMENTS - A manufacturing method of white-light emitting elements that is one example of the present invention is a manufacturing method of a white-light emitting element with the light emitting diode chip covered with the fluorescent-body-containing resin member that has been formed with the fluorescent-body-containing resin material containing a resin and fluorescent bodies, and includes: an irradiating step of irradiating the fluorescent-body-containing resin material with the blue laser beam; a measuring step of measuring the fluorescence strength of the fluorescence light emission from the fluorescent bodies that have been excited by the blue laser beam with which the irradiation has been carried out; and an applying step of applying, to the light emitting diode chip, a quantity of the fluorescent-body-containing resin material, the quantity being based on the fluorescence strength that has been measured. | 2014-03-20 |
20140080232 | PEAK-BASED ENDPOINTING FOR CHEMICAL MECHANICAL POLISHING - A polishing system receives one or more target parameters for a selected peak in a spectrum of light, polishes a substrate, measures a current spectrum of light reflected from the substrate while the substrate is being polished, identifies the selected peak in the current spectrum, measures one or more current parameters of the selected peak in the current spectrum, compares the current parameters of the selected peak to the target parameters, and ceases to polish the substrate when the current parameters and the target parameters have a pre defined relationship. | 2014-03-20 |
20140080233 | COMBINATORIAL OPTIMIZATION OF INTERLAYER PARAMETERS - The embodiments describe methods and apparatuses for combinatorial optimization of interlayer parameters for capacitor stacks. The capacitor stacks may include a substrate, an insulating layer disposed on the substrate, a ruthenium disposed electrode on the insulating layer, and an interlayer disposed on the ruthenium electrode, where the interlayer is configured to prevent etching of the electrode when growing a high-k dielectric using an ozone-based precursor. The parameters for forming the interlayer may include interlayer thickness, precursor chemistry, oxidant strength, precursor purge times, oxidant purge times, and other suitable parameters. Each of these parameters may be evaluated through deposition of the capacitor stacks through a combinatorial optimization process. Thus, a plurality of different parameters may be evaluated with a single substrate to ascertain associated properties of Ruthenium electrode etching in a combinatorial manner. | 2014-03-20 |
20140080234 | LIGHT EMITTING DIODES WITH SMOOTH SURFACE FOR REFLECTIVE ELECTRODE - A light emitting diode comprising an epitaxial layer structure, a first electrode, and a second electrode. The first and second electrodes are separately disposed on the epitaxial layer structure, and the epitaxial layer structure has a root-means-square (RMS) roughness less than about 3 at a surface whereon the first electrode is formed. | 2014-03-20 |
20140080235 | METHOD FOR MANUFACTURING SEMICONDUCTOR LIGHT EMITTING DEVICE - A method for manufacturing a semiconductor light emitting device comprises a sealing step of sealing a semiconductor chip fixed on a lead frame with a sealing member, a removal step of removing the sealing member until a surface of the semiconductor chip becomes exposed, an irregularity formation step of forming fine irregularities on a bond surface formed in the removal step, and a bonding step of bonding a wavelength conversion member to the bond surface. | 2014-03-20 |
20140080236 | MULTICHIP LIGHT EMITTING DIODE (LED) AND METHOD OF MANUFACTURE - The present invention provides a multichip LED and method of manufacture in which white light is produced. A plurality of electrically interconnected LED chips is selected for conversion of light to white light. The LED chips comprise: a blue LED chip, a red LED chip, a green LED chip, and a target LED chip whose light output is converted to white light. A wavelength of a light output by one or more of the plurality of chips will be measured. Based on the wavelength measurement, a conformal coating is applied to the one or more of the LED chips. The conformal coating has a phosphor ratio that is based on the wavelength. The phosphor ratio is comprised of at least one of the following colors: yellow, green, or red. Using the conformal coating, the light output of the target LED is then converted to white light. | 2014-03-20 |
20140080237 | METHOD OF MANUFACTURING ORGANIC ELECTROLUMINESCENT DISPLAY - In a method of manufacturing an organic electroluminescent display, when a substrate including first and second pixel areas is prepared, a first mask including openings is disposed on the substrate to respectively correspond to the first and second pixel areas, and a second mask including an opening corresponding to the first pixel area is disposed on the first mask to expose the first pixel area and cover the second pixel area. Then, a first organic light emitting material is provided to the substrate to form the first organic light emitting material in the first pixel area and the second mask is removed from the substrate to expose the first and second pixel areas. Thereafter, a second organic light emitting material is provided to the substrate to form the second light emitting material in the first and second pixel areas and the first mask is removed from the substrate. | 2014-03-20 |
20140080238 | LIQUID CRYSTAL DISPLAY DEVICE AND METHOD FOR MANUFACTURING THE SAME, AND LIQUID CRYSTAL TELEVISION RECEIVER - At least one or more of a conductive layer which forms a wiring or an electrode and a pattern necessary for manufacturing a display panel such as a mask for forming a predetermined pattern is formed by a method capable of selectively forming a pattern to manufacture a liquid crystal display device. A droplet discharge method capable of forming a predetermined pattern by selectively discharging a droplet of a composition in accordance with a particular object is used as a method capable of selectively forming a pattern in forming a conductive layer, an insulating layer, or the like. | 2014-03-20 |
20140080239 | PATTERNED SUBSTRATE FOR LIGHT EMITTING DIODE AND LIGHT EMITTING DIODE EMPLOYING THE SAME - Disclosed herein are a patterned substrate for a light emitting diode and a light emitting diode employing the patterned substrate. The substrate has top and bottom surfaces. Protrusion patterns are arranged on the top surface of the substrate. Furthermore, recessed regions surround the protrusion patterns. The recessed regions have irregular bottoms. Thus, the protrusion patterns and the recessed regions can prevent light emitted from a light emitting diode from being lost due to the total reflection to thereby improve light extraction efficiency. | 2014-03-20 |
20140080240 | METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE - According to one embodiment, a method for manufacturing a semiconductor device is disclosed. The method can prepare a substrate unit including a base substrate, an intermediate crystal layer, and a first mask layer. The intermediate crystal layer has a major surface having a first region, a second region, and a first intermediate region. The first mask layer is provided on the first intermediate region. The method can implement a first growth to grow a first lower layer on the first region and grow a second lower layer on the second region. The first and second lower layers include a semiconductor crystal. The method can implement a second growth to grow a second upper layer while growing a first upper layer to cover the first mask layer with the first and second upper layers. The method can implement cooling to separate the first and second upper layers. | 2014-03-20 |
20140080241 | MANUFACTURING METHOD OF ORGANIC EL ELEMENT - A method of manufacturing an organic EL element having a pair of electrodes and an organic functional layer disposed therebetween, the pair of electrodes consisting of an upper electrode and a lower electrode, comprising: forming the upper electrode on the organic functional layer by a magnetron sputtering method with a film-forming power density no less than 4.5 W/cm | 2014-03-20 |
20140080242 | METHOD FOR MANUFACTURING PACKAGE STRUCTURE WITH MICRO-ELECTROMECHANICAL ELEMENT - A package structure includes a micro-electromechanical element having a plurality of electrical contacts; a package layer enclosing the micro-electromechanical element and the electrical contacts, with a bottom surface of the micro-electromechanical element exposed from a lower surface of the package layer; a plurality of bonding wires embedded in the package layer, each of the bonding wires having one end connected to one of the electrical contacts, and the other end exposed from the lower surface of the package layer; and a build-up layer structure provided on the lower surface of the package layer, the build-up layer including at least one dielectric layer and a plurality of conductive blind vias formed in the dielectric layer and electrically connected to one ends of the bonding wires. The package structure is easier to accurately control the location of an external electrical contact, and the compatibility of the manufacturing procedures is high. | 2014-03-20 |
20140080243 | METHOD OF MANUFACTURING RADIATION DETECTOR - A method of manufacturing a radiation detector, comprising: a charge blocking layer generating step of generating a charge blocking layer on a substrate; a CdTe-layer generating step of generating a CdTe layer so as to cover the charge blocking layer on the substrate, the CdTe layer undergoing heterojunction to the charge blocking layer and being composed of a chlorine-doped polycrystalline film; and a heat treatment step of performing a heat treatment on the substrate having the CdTe layer formed thereon. | 2014-03-20 |