12th week of 2014 patent applcation highlights part 42 |
Patent application number | Title | Published |
20140079742 | COATING OF FAST ABSORPTION OR DISSOLUTION - A coating of fast absorption or fast dissolution on an implantable device and methods of making and using of the coating are provided. | 2014-03-20 |
20140079743 | COATINGS OF ACRYLAMIDE-BASED COPOLYMERS - An implantable device including a conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided. | 2014-03-20 |
20140079744 | Even Deposition and Low Rub-Off Compositions - Improved deposition and low rub-off compositions are described. The compositions are emulsions with aqueous-based film-forming resins in the water phase and particle with hydrophobic material in the oil phase of the emulsion. The compositions are low rub-off after being topically applied. | 2014-03-20 |
20140079745 | COSMETIC COMPOSITIONS COMPRISING POWDER CONTAINING ALUMINUM HYDROXIDE - The embodiments relate to cosmetic compositions providing a high coverage to the skin while retaining a natural skin appearance. The compositions of embodiments include a powder-containing aluminum hydroxide particles having an average coated ratio of from about 60% to about 150% powder by weight of aluminum hydroxide, and a cosmetically acceptable carrier. The compositions may be useful as a foundation and/or as a composition to correct skin discoloration. | 2014-03-20 |
20140079746 | FULLERENES AND OTHER CAGE MOLECULAR STRUCTURES IN A SPECIAL HYDRATED STATE - The invention relates to fullerenes and other fullerene-like caged molecular structures in a special hydrated state. The above-mentioned hydrated compounds can be described by the following general formulae: (xAi@C | 2014-03-20 |
20140079747 | Spray Drying Microcapsules - Spray drying microcapsules with particulates, the microcapsules that result from such spray drying, and compositions and methods of making said compositions including the spray-dried microcapsules. | 2014-03-20 |
20140079748 | ANHYDROUS COMPOSITIONS HAVING MICROCAPSULES AND NON-VOLATILE OILS - Anhydrous compositions having microcapsules and non-volatile oils; and methods related thereto. | 2014-03-20 |
20140079749 | COMPOSITIONS AND METHODS FOR IMPROVED SKIN CARE - Compositions and methods for administering collagen to a human subject have been developed. The collagen-containing lipid vesicles of the invention provide a delivery system for human collagen which eliminates problems associated with chemical and physical instability of the collagen as well as immune responses to non-human collagen. | 2014-03-20 |
20140079750 | TOOTH REMINERALIZING ORAL CARE COMPOSITIONS - Oral care compositions suitable for whitening and remineralizing teeth are described. The oral care compositions comprise a phosphate source and regeneration-source calcium salt having a particle size of five (5) microns or less so that in-situ hydroxyapatite may be generated upon use. | 2014-03-20 |
20140079751 | METHOD OF USING COMPOSITE OF SILVER NANOPARTICLES AND NANOSILICATE PLATELETS TO INHIBIT GROWTH OF SILVER-RESISTANT BACTERIA - The present invention provides a method of using a composite of spherical silver nanoparticles and layered inorganic clay, in particular nanosilicate platelets, for inhibiting the growth of silver-resistant bacteria. The layered inorganic clay serves as carriers of the silver nanoparticles and disperses them. The composite has a particle size of about 5 nm to 100 nm. The silver nanoparticles can be dispersed in an organic solvent or water. | 2014-03-20 |
20140079752 | Injectable, Pore-Forming Hydrogels for Materials-Based Cell Therapies - The invention provides compositions and methods to form pores in situ within hydrogels following hydrogel injection. Pores formed in situ via degradation of sacrificial porogens within the surrounding hydrogel facilitate recruitment or release of cells. Disclosed herein is a material that is not initially porous, but which becomes macroporous over time. | 2014-03-20 |
20140079753 | BMP BINDING PEPTIDES - Compositions and methods for tissue repair are provided including cell binding peptides and BMP binding peptides. The cell binding peptides bind to one or more of stem cells and fibroblasts. The tissue for repair includes bone, tendon, muscle, connective tissue, ligament, cardiac tissue, bladder tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and/or BMP binding peptides are attached, such as acellular extracellular matrix having attached binding peptide and bone graft material comprising a ceramic. | 2014-03-20 |
20140079754 | MICROFABRICATED NANOPORE DEVICE FOR SUSTAINED RELEASE OF THERAPEUTIC AGENT - A drug delivery device that includes a capsule for implantation into the body; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for allowing the substance to diffuse from or otherwise exit the reservoir, and a nanopore membrane in communication with the capsule at or near the exit port for controlling the rate of diffusion of the substance from the exit port. The device also includes an optional screen for providing structural stability to the nanopore membrane and for keeping the pores of the nanopore membrane clear. One embodiment of the drug delivery device includes an osmotic engine internal to the device for creating fluid flow through the device. | 2014-03-20 |
20140079755 | SELF-EXPANDING DEVICES AND METHODS THEREFOR - Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here. | 2014-03-20 |
20140079756 | Compressed Chewing Gum Tablet - A compressed chewing gum tablet includes at least a first and a second chewing gum module, the first chewing gum module including a first chewing gum composition including at least a first active ingredient and chewing gum granules containing gum base, the second chewing gum module including a second chewing gum composition including at least a second active ingredient and chewing gum granules containing gum base, wherein the first active ingredient is a pharmaceutically active ingredient, and the second active ingredient is selected from the group consisting of pharmaceutically active ingredients and enhancers, wherein the gum base content of the first and second chewing gum modules is different. | 2014-03-20 |
20140079757 | ORAL DRUG DELIVERY FORMULATIONS - The invention generally relates to the preparation and use of consumable products for delivering a bioactive agent to an oral cavity of a mammal. In certain embodiments, the invention provides a consumable product that releases a bioactive agent within an oral cavity of a mammal, the product including a polymer matrix and one or more bioactive agents, in which the matrix is of a heterogeneous thickness. | 2014-03-20 |
20140079758 | ELECTROSPUN MATERIAL COVERED MEDICAL APPLIANCES AND METHODS OF MANUFACTURE - A medical appliance or prosthesis may comprise one or more layers of electrospun nanofibers, including electrospun polymers. The electrospun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Electrospun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. | 2014-03-20 |
20140079759 | FIBROUS POLYMER SCAFFOLDS HAVING DIAMETRICALLY PATTERNED POLYMER FIBERS - Fibrous polymer scaffolds having at least one layer of diametrically patterned fibers, as well as methods of manufacture, are provided. The scaffolds can be formed of multiple layers and the extent and direction of alignment of each layer can be controlled. Fabrication systems and methods for producing such scaffolds including apparatuses and processes are also provided. | 2014-03-20 |
20140079760 | Phenyl Ester Side Chains to Increase Polymer Resorptivity - The present invention relates to polymers modified to increase their resorbability. In particular, the polymers of the invention have phenyl ester side chains which are good leaving groups and which thereby increase the resorption rate of the polymer relative to the same polymer, for example, bearing a comparable amount of an alkyl ester side chain. Such polymers are generally water insoluble, but when modified are able to solubilize drugs and upon degradation and resorption, release those in a physiological environment in a controlled and/or sustained manner. | 2014-03-20 |
20140079761 | SYSTEMS AND METHODS FOR TREATMENT OF ACNE VULGARIS AND OTHER CONDITIONS WITH A TOPICAL NITRIC OXIDE DELIVERY SYSTEM - The present invention generally relates to compositions and methods for treatment of subjects having or at risk of acne or other conditions. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto a location with acne, or on another suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like. | 2014-03-20 |
20140079762 | TREATMENT OF SKIN AND SOFT TISSUE INFECTION WITH NITRIC OXIDE - The present invention generally relates to compositions and methods for treatment of skin and/or other soft tissues that are infected with bacteria such as | 2014-03-20 |
20140079763 | METHODS AND SYSTEMS FOR TREATMENT OF INFLAMMATORY DISEASES WITH NITRIC OXIDE - The present invention generally relates to compositions and methods for treatment of various inflammatory diseases, such as inflammatory dermatoses and other conditions, e.g., using nitric oxide. Examples of such dermatoses include psoriasis, atopic dermatitis, and contact dermatitis. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto an inflammation site, or other suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like. | 2014-03-20 |
20140079764 | TREATMENT AND PREVENTION OF LEARNING AND MEMORY DISORDERS - The present invention generally relates to compositions and methods for transdermal drug delivery, including treatment and prevention of learning and memory disorders, and enhancement of learning or memory. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like. | 2014-03-20 |
20140079765 | TECHNIQUES AND SYSTEMS FOR TREATMENT OF NEUROPATHIC PAIN AND OTHER INDICATIONS - The present invention generally relates to compositions and methods for treatment of subjects having or at risk of neuropathic pain or other conditions. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto a location with neuropathic pain, or on another suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like. | 2014-03-20 |
20140079766 | METHODS AND COMPOSITIONS FOR MUSCULAR AND NEUROMUSCULAR DISEASES - The present invention generally relates to compositions and methods for treatment of subjects in need of muscle growth or repair. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto a location where muscle growth is desired, or on another suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like. | 2014-03-20 |
20140079767 | CANCER TREATMENTS AND COMPOSITIONS FOR USE THEREOF - The present invention generally relates to compositions and methods for treatment of subjects having or at risk of cancer or other conditions. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like. | 2014-03-20 |
20140079768 | COMPOSITIONS AND METHODS FOR TREATMENT OF OSTEOPOROSIS AND OTHER INDICATIONS - The present invention generally relates to compositions and methods for treatment of subjects having or at risk of osteoporosis or other conditions. In some cases, the composition may include nitric oxide. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto a suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like. | 2014-03-20 |
20140079769 | METHODS FOR PREDICTING THE PROGRESSION AND TREATING A CHRONIC KIDNEY DISEASE IN A PATIENT - The present invention relates to a method for predicting the progression of chronic kidney disease (CKD) in a patient and also to an inhibitor of NGAL gene expression or an NGAL antagonist for use in the prevention or the treatment of CKD. | 2014-03-20 |
20140079770 | VECTOR FOR PULMONARY DELIVERY, INDUCING AGENT, AND USES - The present invention provides a liposome having excellent lung migration ability that had not existed hitherto, by including GALA or Chol-GALA in the liposome. Furthermore, by using the liposome, a pulmonary delivery carrier having a stronger knockdown effect of siRNA when compared to existing carriers is provided. | 2014-03-20 |
20140079771 | METHODS AND COMPOSITIONS FOR TREATMENT OF METABOLIC DISORDERS - The present invention relates to the discovery that increases in invariant NKT cell (iNKT) number and/or activity can reduce the incidence or severity of metabolic disorders such as obesity and diabetes. The invention accordingly features methods, kits, and compositions for the treatment of such metabolic disorders by administration of a composition capable of increasing iNKT activity. | 2014-03-20 |
20140079772 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER - The present invention discloses anti-cancer compositions, and associated methods, including an anti-cancer composition comprising: a cellular energy inhibitor having the structure according to formula I | 2014-03-20 |
20140079773 | ENCAPSULATING LIPOSOMES - Provided herein is technology relating to liposomes and particularly, but not exclusively, to compositions of liposomes encapsulating a biologically active agent, methods of preparing liposomes encapsulating a biologically active agent, and uses of liposomes encapsulating a biologically active agent to treat a subject. | 2014-03-20 |
20140079774 | POROUS NANOPARTICLE-SUPPORTED LIPID BILAYERS (PROTOCELLS) FOR TARGETED DELIVERY AND METHODS OF USING SAME - The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery. | 2014-03-20 |
20140079775 | AGENTS TO TREAT/PREVENT AMOEBIASIS - The invention provides formulations comprising isolated lacto-N-tetraose (LNT) or galactooligosaccharides (GOS) or variants, isomers, analogs and derivatives thereof and a pharmaceutically acceptable carrier. | 2014-03-20 |
20140079776 | Nanostructures for Drug Delivery - The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a plurality of particles comprising a platinum(IV) therapeutically active precursor. | 2014-03-20 |
20140079777 | DRY POWDER VANCOMYCIN COMPOSITIONS AND ASSOCIATED METHODS - Dry powder vancomycin compositions and methods for administering and preparing such compositions are provided. | 2014-03-20 |
20140079778 | Pharmaceutical Formulations Including An Amine Compound - The present invention relates to solid, semisolid, or liquid formulations comprising water soluble antioxidants that prevent or reduce formic acid and/or formyl species generation in the dosage form during the manufacturing process and/or during shelf-life storage. The formulations of the present invention prevent or reduce formation of N-formyl impurities (and gelatin crosslinking) during the manufacturing process and/or during shelf-life storage. | 2014-03-20 |
20140079779 | Modified Release Tranexamic Acid Formulation - A modified release dosage form for the oral administration of tranexamic acid. | 2014-03-20 |
20140079780 | Crush resistant delayed-release dosage forms - The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed. | 2014-03-20 |
20140079781 | PHARMACEUTICAL COMPOSITIONS - The present invention relates to pharmaceutical compositions comprising fixed dose combinations of a DPP-4 inhibitor drug and pioglitazone, processes for the preparation thereof, and their use to treat certain diseases. | 2014-03-20 |
20140079782 | PARTICULATE MATERIALS - The present invention relates to active substances in particulate form, to methods for preparing them and to their uses. The present invention provides particulate powders, such as might be of use for delivery using a dry powder inhaler (DPI) or similar delivery device, having properties which may be beneficial to the DPI delivery process. | 2014-03-20 |
20140079783 | Pharmaceutical Compositions Comprising Rifaximin and Amino acids, Preparation Methods and Use Thereof - The present invention relates to rifaximin compositions comprising amino acids, characterized in that they increase rifaximin solubility in aqueous solutions and are useful in the treatment of disease wherein amino acids and rifaximin are efficacious. The present invention also relates to pharmaceutical compositions comprising rifaximin or one of the pharmaceutically acceptable salts thereof and one or more amino acid(s), wherein the molar ratio between the amino acid(s) and rifaximin is from 1:1 to 10:1, together with pharmaceutically acceptable excipients. The present invention further relates to rifaximin crystals obtained by dissolving rifaximin and amino acids in solutions formed by ethanol/water and evaporating the solution. | 2014-03-20 |
20140079784 | AEROSOLIZED LFA-1 ANTAGONISTS FOR USE IN LOCALIZED TREATMENT OF IMMUNE RELATED DISORDERS - This invention provides specifically formulated LFA-1 antagonists or pharmaceutically acceptable salts thereof that are suitable for aerosolized delivery. In particular, the LFA-1 antagonists are particularly well suited for localized treatment by having a rapid systemic clearance rate. The invention also encompasses methods of treatment and prevention of immune related disorders using the LFA-1 aerosolized formulations of the present invention. | 2014-03-20 |
20140079785 | COMPOSITION COMPRISING LIPID NANOPARTICLES AND A CORTICOSTEROID OR VITAMIN D DERIVATIVE - A pharmaceutical composition comprises, as a therapeutically active ingredient, a corticosteroid and/or vitamin D derivative incorporated as a solid solution or dispersion in lipid nanoparticles, said lipid nanoparticles being solid at ambient temperature and comprising a first lipid with a melting point above body temperature, the first lipid being a wax selected from the group consisting of esters of C | 2014-03-20 |
20140079786 | Fiber Spheres - The disclosure pertains generally to spheres made from a fiber source. These spheres may be used as cores for carrying other ingredients or may be used alone for applications in the food, pharmaceutical, nutraceutical, personal care, and industrial industries. In many embodiments the ingredients used in this invention are derived from a natural resource, and are safe to ingest. In some embodiments, the spheres are formed using a centrifugal tumbling-granulating-coating apparatus. | 2014-03-20 |
20140079787 | METHODS FOR TREATING HEPATOCELLULAR CARCINOMA - The present invention provides methods and compositions for treating hepatocellular carcinoma (HCC) by administering a composition comprising nanoparticles that comprise a taxane and an albumin. The invention also provides combination therapy methods of treating HCC comprising administering to an individual an effective amount of a composition comprising nanoparticles that comprise a taxane and an albumin and another agent, such as an agent that inhibits microtubule disassembly. | 2014-03-20 |
20140079788 | METHODS OF TREATMENT OF PANCREATIC CANCER - The present invention provides methods and compositions for treating pancreatic cancer in an individual who has been previously treated for pancreatic cancer (e.g., gemcitabine-based therapy) by administering a composition comprising nanoparticles that comprise a taxane and an albumin. The invention also provides combination therapy methods of treating pancreatic cancer (for example, in an individual who has been previously treated for pancreatic cancer) comprising administering to an individual an effective amount of a composition comprising nanoparticles that comprise a taxane and an albumin and another agent. | 2014-03-20 |
20140079789 | Bioglass with Glycosaminoglycans - One or more particles of bioactive glass coated with a glycosaminoglycan, wherein the glycosaminoglycan is bound to the bioactive glass and methods of treatment using such particles. | 2014-03-20 |
20140079790 | MULTI-ENCAPSULATED FORMULATIONS MADE WITH OXIDIZED CELLULOSE FOR IN-SITU REACTIONS - A microsphere and methods for forming the same are disclosed. The microsphere includes modified cellulose and at least one of precursors for is-situ polymerization or endothermic/exothermic reactions. | 2014-03-20 |
20140079791 | PHARMACEUTICAL PREPARATIONS CONTAINING HIGHLY VOLATILE SILICONES - The subject of the present invention is a transdermal preparation containing pharmaceutically active ingredient, wherein the particles of the active ingredient are coated with highly volatile silicones or a mixture thereof, and these coated particles are dispersed in a gel or cream base. The volatile silicone component is hexamethyldisiloxane and/or octamethyltrisiloxane and/or decamethylpentacyclo-siloxane. A further subject of the present invention is a method for the preparation of such pharmaceutical compositions. | 2014-03-20 |
20140079792 | COATING COMPOSITION SUITABLE FOR PHARMACEUTICAL OR NUTRACEUTICAL DOSAGE FORMS - The invention relates to a coating composition suitable for the coating of pharmaceutical or nutraceutical dosage form, comprising a core comprising one or more pharmaceutical or nutraceutical active ingredients, wherein the coating composition is comprising at least 20% by weight of an enteric core/shell polymer composition derived from an emulsion polymerisation process, wherein the core of the core/shell polymer composition is formed by a water-insoluble, cross-linked polymer or copolymer and the shell of the core/shell polymer composition is formed by an anionic polymer or copolymer. | 2014-03-20 |
20140079793 | COMBINATIONS AND MODES OF ADMINISTRATION OF THERAPEUTIC AGENTS AND COMBINATION THERAPY - The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents (such as an anti-VEGF antibody), or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime. | 2014-03-20 |
20140079794 | GELATIN PARTICLE AND USE THEREOF, AND DEVICE FOR ADMINISTRATION OF PHYSIOLOGICALLY ACTIVE SUBSTANCE - The present invention relates to a gelatin particle, which is a thermally crosslinked non-porous spherical gelatin particle having a circularity of 0.8 or more and a dry particle diameter of 20 to 1,600 μm. The average volume swelling ratio of the gelatin particle in a case where the gelatin particle is immersed in physiological saline at 23° C. is from 200 to 2,000% relative to an average volume of the gelatin particle in a dried state. As for a swollen gelatin particle, it is preferable that the gelatin used has a jelly strength of 80 to 120 g and the swollen gelatin particle has a particle diameter of 50 to 2,000 μm. The gelatin particle can be used for blood vessel embolization and also for controlled release of physiologically active substance. | 2014-03-20 |
20140079795 | MUCOADHESIVE PARTICULATE FORMULATION FOR INDUCING ANTIGEN-SPECIFIC IMMUNE TOLERANCE - The present disclosure relates to a mucoadhesive composition, adapted for preventing and/or treating a pathological reaction of the immune system of an individual, by inducing a specific tolerance towards at least one antigen involved in said pathological reaction, comprising chitosan particles loaded with said at least one antigen involved in the pathological reaction, wherein the size of the loaded chitosan particles is of more than 800 nm. | 2014-03-20 |
20140079796 | Sustained Release Oral Dosage Forms Comprising Low Melting Propionic Acid Derivative Particles - Low melting propionic acid derivative particles that are free flowing and have significantly reduced or eliminated throat burn are disclosed. A method of manufacturing the low melting propionic acid derivative particles; dosage forms containing the low melting propionic acid derivative particles; methods of manufacturing the dosage forms; and methods of treatment using the dosage forms are also disclosed. | 2014-03-20 |
20140079797 | SKIN FORMULATION, PREPARATION AND USES THEREOF - Serum compositions for application to skin are described which contain an amniotic fluid extract in combination with embryonic stem cells. Formulations containing the serum composition are also described. The serum compositions and formulations may be applied to skin for treatment of symptoms of aging, wounds, burns, scars or other skin lesions. Methods of preparing the serum compositions and formulations are also disclosed. | 2014-03-20 |
20140079798 | WHOLE, LEECH SALIVA PRODUCT AND APPLICATIONS THEREOF - Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant. | 2014-03-20 |
20140079799 | TREATING DIABETES WITH A WHOLE, LEECH SALIVA EXTRACT - Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant. | 2014-03-20 |
20140079800 | ANTIOXIDANT THERAPY WITH A WHOLE, LEECH SALIVA EXTRACT - Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant. | 2014-03-20 |
20140079801 | Process for Making a Honey Product Having a Low Water Content - The present disclosure relates to a process for making a honey product having a low water content as well as honey products obtained using the process. The honey product retains the physical and palatable properties of untreated honey while having a prolonged shelf-life. It can be advantageously used to sweeten beverages (such as hot beverages) and in the manufacture of throat lozenges and/or confectionery. | 2014-03-20 |
20140079802 | METHODS TO TREAT NERVOUS SYSTEM CONDITIONS - Methods to treat nervous system conditions. In at least one embodiment of a method of treating a mammalian patient having a neuronal injury or insult of the present disclosure, the method comprises the step of administering a therapeutically-effective dose of a stem cell conditioned medium to a mammalian patient, the stem cell conditioned medium comprising a cell culture supernatant containing at least one factor capable of exerting effective neuroprotection to treat a mammalian neural injury or insult. | 2014-03-20 |
20140079803 | OPTIMIZING EGG PRODUCTION CHARACTERISTICS VIA SEAWATER MINERALIZATION - Aspects for utilizing a seawater fluid to optimize egg-production characteristics are disclosed. In one aspect, a method is provided, which includes identifying a desired optimization, determining a corresponding seawater to non-seawater ratio, and generating a seawater fluid according to the ratio. An egg-cultivation method is also provided, which includes ascertaining a desired optimization, selecting a corresponding seawater to non-seawater ratio, and providing a seawater fluid comprising the ratio to a hen. In another egg-cultivation method, hens are provided with a mixed feed comprising a feed to seawater-mineralized produce ratio selected according to a desired optimization. A method to grow produce is also provided, which includes mineralizing soil with a seawater fluid comprising a seawater to non-seawater ratio corresponding to a preferred optimization. In another aspect, a method to produce feed is disclosed, which includes mixing feed with mineralized produce according to a ratio corresponding to a desired optimization. | 2014-03-20 |
20140079804 | COMPOSITIONS AND METHODS FOR TREATMENT OF INFECTIONS - This invention relates to the field of topical treatments for infections such as nail infections, particularly fungal infections of the nail commonly referred to as onychomycosis. Particularly, the invention relates to novel compositions containing peroxide for the treatment of such nail infections and other infections. | 2014-03-20 |
20140079805 | ANTIOXIDANT AND ANTIMICROBIAL WOUND DRESSING MATERIALS - A wound dressing material comprising a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt. The substrate may comprise collagen and/or oxidized regenerated cellulose complexed to Ag | 2014-03-20 |
20140079806 | PENFLUFEN AS A WOOD PRESERVATIVE AGAINST XYLOPHAGOUS BASIDIOMYCETES - The invention relates to the use of penflufen for protecting wood and wood-comprising materials against wood-destroying basidiomycetes. | 2014-03-20 |
20140079807 | ANTIMICROBIAL ACTION OF COPPER IN GLASS - The disclosure is directed to glass compositions that incorporate copper into an otherwise homogeneous glass and to a method for making such glass. This incorporation of the copper into the glass composition imparts significant antimicrobial activity to the glass. A method of making a copper-containing glass article comprises: batching a glass batch comprising: 40-85 SiO | 2014-03-20 |
20140079808 | INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES - Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an active compound as described herein, or an agriculturally acceptable salt thereof. Methods of enhancing a microbicide (e.g., including a copper, antibiotic, bacteriophage, etc.) and/or plant defense activator are also provided, including applying an active compound as described herein. Compositions comprising an active compound as described herein in an agriculturally acceptable carrier are also provided, and in some embodiments the compositions further include a microbicide (e.g., including copper, antibiotic, bacteriophage, etc.) and/or plant defense activator. | 2014-03-20 |
20140079809 | COMPOUNDS USEFUL FOR THE PREVENTION OR TREATMENT OF ACCOMMODATIVE ASTHENOPIA - The use of L-carnitine, in combination with antioxidants such as vitamin E and inorganic elements such as manganese, zinc, sodium and potassium, for the preparation of a physiological supplement or medicament for ophthalmic use, for the prevention or treatment of accomodative asthenopia is disclosed. | 2014-03-20 |
20140079810 | X-RAY CONTRAST MEDIA COMPOSITIONS AND METHODS OF USING THE SAME - Embodiments disclosed herein relate to improved X-ray contrast media compositions and methods of using the same for treating symptoms related to allergic reactions, inflammatory conditions, symptoms of the common cold and certain cancers. | 2014-03-20 |
20140079811 | X-RAY CONTRAST MEDIA COMPOSITIONS AND METHODS OF USING THE SAME TO TREAT, REDUCE OR DELAY THE ONSET OF CNS INFLAMMATION AND INFLAMMATION ASSOCIATED CONDITIONS - Embodiments disclosed herein relate to improved X-ray contrast media compositions and methods of using the same for treating symptoms related to allergic reactions, inflammatory conditions, symptoms of the common cold and certain cancers. | 2014-03-20 |
20140079812 | Disulfide Chemotherapeutic Agents and Methods of Use Thereof - Compositions and methods for the treatment of cancer are provided. | 2014-03-20 |
20140079813 | Genes Associated With Post Relapse Survival And Uses Thereof - Provided are methods, systems and kits for predicting post-relapse survival of a cancer patient and for identifying cancer genes predictive of the post-relapse survival of the patient. Values representing gene expression levels of a group of genes associated with survival of the cancer cells are determined using gene expression profiling platforms and a plurality of probe sets that hybridize to one or more of the genes in the group. A predictive model establishes a predictive value based on the weighted contribution of each gene associated with survival of the cancer cells to risk of death for the cancer patient and imports expression values of the genes in the group that is indicative of a risk of death for the relapsed patient. Using global gene expression profiling and statistical analysis, expression of cancer cell genes at baseline and at first relapse that are involved in interaction of cancer cells with cells in their microenvironment, can be used to identify genes that are predictive of post-relapse survival. | 2014-03-20 |
20140079814 | Method and Composition for Treating Gastro-Esophageal Disorders - An orally administered composition that includes least one alkaline agent with a pH of at least 9.0 to 12.0, mixed in an aqueous vehicle with relatively high surface tension, high viscosity and lateral adhesion properties. When mixed, a low water soluble emulsion is formed that evenly coats and partially adheres to the lower section of the esophagus and the LES and forms a relatively long acting, protective barrier and partially neutralizes gastric acid. In one embodiment, the alkaline agent is potassium hydroxide and the aqueous vehicle is made of hydroxypropyl methyl cellulose, polyethylene glycol or ethylene glycol and additional thickener agents capable of withstanding high pH environments, such as xanthan gum, croscarmellose sodium, and microcrystalline cellulose. Additional organoleptic agents, such as gum Arabic and polyethylene glycol, flavorings, such as sodium chloride, acesulfame potassium, sodium saccharine, and mint, and stabilizers such as colloidal silica made be added. | 2014-03-20 |
20140079815 | COMPOSITIONS FOR STIMULATING HAIR GROWTH AND PREVENTING HAIR LOSS - A composition for promoting hair growth, slowing hair loss, and for preventing or minimizing hair loss that do not suffer from the deficiencies of the prior art. One exemplary embodiment is directed to a topical formulation for hair, the formulation combining arnica and aqua ammonia to promote hair growth and hair loss diminution. | 2014-03-20 |
20140079816 | CROSS-LINKED BIOPOLYMERS, RELATED COMPOSITIONS AND METHODS OF USE - The present invention provides stabilized oil-in-water emulsions with an extended range of chemical, thermal and/or mechanical stabilities, and method(s) for their preparation. Such preparations provide an environmentally-protective biopolymer component exhibiting improved adherence to the dispersed phase, reducing or eliminating dissociation therefrom under such conditions, for use in the context of a range of food, pharmaceutical, personal care, health care, cosmetic and other end-use applications. | 2014-03-20 |
20140079817 | COMPOSITION FOR ENHANCING MEMORY AND MITIGATING NEURODEGENERATION AND METHOD THEREOF - The present invention provides a composition for enhancing memory and mitigating neurodegeneration comprising an effective amount of a | 2014-03-20 |
20140079818 | BOEHMERIA EXTRACT AND ITS USE IN TREATING LIVER DISEASES - A method for treating liver fibrosis. The method includes administering to a subject suffering from liver fibrosis a pharmaceutically active extract obtained from a | 2014-03-20 |
20140079819 | NATURAL PRESERVATIVE ALTENATIVES AND COMPOSITIONS CONTAINING SAME - A cosmetic preservative is disclosed which comprises Lonerica sp. extract, a metal chelating agent and ethanol in amounts effective to inhibit microbial growth including bacteria, molds and yeast. The effectiveness may be enhanced by the addition of a phospholipid, ascorbic acid and ascorbic acid salts. Effectiveness against microbial growth is further improved by addition of a combination of 1,2-hexanediol, 1,2 octanediol and tropolone. Specific formulations are provided. | 2014-03-20 |
20140079820 | CINNAMOMUM BURMANII EXTRACT, EXTRACTION PROCESS AND ITS USE AS PROTON PUMP DOWN-REGULATOR, ENZYME INHIBITOR, AND MUCOPROTECTOR - Extract and/or fraction from | 2014-03-20 |
20140079821 | METHODS FOR IMPROVING HEALTH IN HUMANS - Embodiments of the invention generally relate to methods and supplements for improving the health of human beings. | 2014-03-20 |
20140079822 | METHODS FOR IMPROVING SLEEP EFFICIENCY IN HEALTHY HUMAN BEINGS - Embodiments of the invention generally relate to methods and supplements for improving sleep efficiency in human beings. | 2014-03-20 |
20140079823 | METHODS FOR TREATING POST-TRAUMATIC STRESS DISORDER - Embodiments herein relate to nutritional supplements for treating post-traumatic stress disorder in human beings, and to methods of using the same. In particular examples, the nutritional supplement comprises an amino acid secretagogue composition. | 2014-03-20 |
20140079825 | METHODS FOR IMPROVING HEALTH IN CANINES - A method of improving health in a canine includes administering to the canine a nutritional supplement comprising an amino acid secretagogue composition, which stimulates the pituitary gland of the canines to produce growth hormone. The nutritional supplement may be administered orally. The nutritional supplement may comprise L-arginine hydrochloride, Oxo-proline, L-lysine hydrochloride, and cysteine. When desired, the nutritional supplement may consist essentially of L-arginine hydrochloride, Oxo-proline, L-lysine hydrochloride, N-acetyl-L-cysteine, L-glutamine, and schizonepeta powder. | 2014-03-20 |
20140079826 | COMPOSITIONS AND METHODS FOR INCREASING HUMAN GROWTH HORMONE LEVELS - Embodiments of the invention generally relate to methods and supplements for increasing human growth hormone (hGH) levels in healthy human beings. | 2014-03-20 |
20140079827 | METHODS FOR IMPROVING HEALTH IN ANIMALS - A method of improving health in an animal includes administering to the animal a nutritional supplement comprising an amino acid secretagogue composition, which stimulates the pituitary gland in the animal to produce growth hormone. The nutritional supplement may be administered orally. The nutritional supplement may comprise L-arginine hydrochloride, L-pyroglutamic acid, L-lysine hydrochloride, and cysteine. When desired, the nutritional supplement may consist essentially of L-arginine hydrochloride, L-pyroglutamic acid, L-lysine hydrochloride, N-acetyl-L-cysteine, L-glutamine, and schizonepeta powder. | 2014-03-20 |
20140079828 | METHODS FOR INCREASING HUMAN GROWTH HORMONE LEVELS - Embodiments of the invention generally relate to methods and supplements for increasing human growth hormone (hGH) levels in healthy human beings. | 2014-03-20 |
20140079830 | METHODS FOR IMPROVING THYROID FUNCTION IN A SUBJECT - Embodiments of the invention generally relate to methods for improving thyroid function in healthy human beings. | 2014-03-20 |
20140079831 | COMPOSITIONS FOR INCREASING HUMAN GROWTH HORMONE LEVELS - Embodiments of the invention generally relate to supplements for increasing human growth hormone (hGH) levels in healthy human beings. | 2014-03-20 |
20140079832 | METHODS AND COMPOSITIONS FOR INCREASING GROWTH HORMONES - Embodiments of the invention generally relate to methods and supplements for improving the health of human beings. | 2014-03-20 |
20140079833 | FOOD PRODUCT COMPRISING RYE - A rye extract as well as food compositions including the extract. The use of the extract for the manufacture of a food composition, a dosage product, a pharmaceutical or a medicament. The extract is useful as a food composition, dosage product, pharmaceutical or medicament for the treatment, controlling or prevention of diseases or conditions related to metabolic syndrome, diabetes or obesity or in the promotion of satiety, weight loss or maintenance of desired body weight. | 2014-03-20 |
20140079834 | BIOACTIVE FRACTIONS AND COMPOUNDS FROM DALBERGIA SISSOO FOR THE PREVENTION OR TREATMENT OF OSTEO-HEALTH RELATED DISORDERS - The present invention relates to bioactive fractions and compounds from | 2014-03-20 |
20140079835 | COMPOSITIONS CONTAINING RESVERATROL AND ESSENTIAL OIL OF CLOVES FOR THE TREATMENT OF ITCHING - The present invention relates to a patch or sticking plaster formulation containing a combination of resveratrol or derivatives thereof and essential oil of cloves ( | 2014-03-20 |
20140079836 | METHODS AND COMPOSITIONS FOR ALTERING HEALTH, WELLBEING, AND LIFESPAN - Described herein are the results of comprehensive genetic expression and other molecular analysis of the effect of antioxidants on biological systems, including specifically different human cells. Based on these analyses, methods and compositions are described for modifying or influencing the lifespan of cells, tissues, organs, and organisms. In various embodiments, there are provided methods for modulating the activity of the gene maintenance process in order to influence the length and/or structural integrity of the telomere in living cells, as well as methods for modulating the rate/efficiency of the cellular respiration provided by the mitochondria, mitochondrial biogenesis, and maintenance of the mitochondrial membrane potential. Exemplary lifespan altering compounds include natural and synthetic antioxidants, such as plant antioxidant and polyphenol compounds derived from coffee cherry, tea, berry, and so forth, including but not limited to caffeic acid, chlorogenic acid, ferulic acid, quinic acid, proanthocyanidins, ubiquinone, idebenone, or a synthetic form or derivatives thereof. | 2014-03-20 |
20140079837 | TIRE VULCANIZER AND TIRE VULCANIZING SYSTEM - A tire vulcanizer and tire vulcanizing system improving production efficiency by shortening time for loading and unloading of tires are provided. They include: a lower mold supporting part; an upper mold supporting part; a moving device moving the upper mold supporting part horizontally; an elevator device moving the upper mold vertically; a lift device pushing up a vulcanized tire held in the lower mold; and a tire supporting part supported by the upper mold supporting part. The tire supporting part moves between a supporting position and a retreated position. The bottom side of the vulcanized tire is supported by the tire supporting part at a peripheral side closer to the outside than a pushed-up position in the supporting position. The retreated position is positioned at a peripheral side closer to the outside than the vulcanized tire. | 2014-03-20 |
20140079838 | METHOD AND MANUFACTURING LINE FOR MANUFACTRING WIND TURBINE BLADES - Manufacturing line for manufacturing wind turbine blades having a composite shell structure comprising a matrix material and a fibre reinforcement material by use of a resin transfer moulding process is used to assemble wind turbine blades formed in a number of moulds, including at least a first mould part having a first mould cavity. A gantry moves along the manufacturing line, in which the manufacture includes a) arranging fibre reinforcement material in the first mould cavity of a first mould using the gantry means, b) moving the gantry means along the manufacturing line to a second mould, c) supplying curable matrix material into the first mould cavity of the first mould, while substantially simultaneously arranging fibre reinforcement material in the first mould cavity of a second mould using the gantry means. The manufacturing line comprises a plurality of moulds for forming wind turbine blades. | 2014-03-20 |
20140079839 | STRETCH-BLOW MOLDING MACHINE - A stretch-blow molding machine having at least one blow molding station, in which a split blow mold, an adjustable blow nozzle with a valve section, a stretching rod with a stretching rod drive system, and an electronic control unit are provided, the electronic control unit arranged in the blow molding station is equipped with hardware and software for selectively operating the blow molding station with a combination of a cam drive and a pneumatic drive, or a combination of an electric servo drive and a pneumatic drive, or only an electric servo drive in the stretching rod drive system. The movement of the stretching rod is initiated in the stretch-blow molding machine in the production process of a container by means of an electric servomotor with the beginning of or during the locking phase of the blow mold and before the blow nozzle is placed, and the stretching rod is already displaced to a position in which the stretching rod is either very closely approached to the preform bottom or contacts the preform bottom, or has even already pre-stretched the preform, until the blow nozzle is placed. | 2014-03-20 |
20140079840 | Apparatus for Injection Molding - An apparatus for facilitating removal and installation of mold insert members of a mold assembly from and into the clamp unit of an injection molding machine comprising a material distributing sub-assembly from which at least one material distributing nozzle projects, the apparatus comprises a two-part frame comprising an ejector part, an injection part being releasably connectable to the material distributing sub-assembly, and support pins spanning between the ejector part and the injection part when the injection part is separated from the material distributing sub-assembly, and guide elements projecting from the material distributing sub-assembly to engage a mold insert member received in the injection part and effective to align that mold insert member relative to the material distributing sub-assembly. The two-part frame comprises first clearance bores and second clearance bores allowing protrusion into the mold insert member of, respectively, the material distributing nozzles and the guide elements. | 2014-03-20 |
20140079841 | MULTICOLOURED FUSED DEPOSITION MODELLING PRINT - The invention relates to a modified fused deposition modeling process for production of multicolored three-dimensional objects. More particularly, the invention relates to a 3D printing process with which 3D objects with particularly good color appearance compared to the prior art can be produced. The process according to the invention is based on coloring of the polymer strand used for production of the actual object in the nozzle, and on using a mixing apparatus which comprises a plurality of injection needles, a static mixer or a dynamic mixer. | 2014-03-20 |
20140079842 | PATTY-FORMING APPARATUS WITH BOTTOM FEED AND ROTARY PUMP - The food product machine with a food supply, a rotary food pump connected to the food supply, a molding mechanism having a mold plate and a knockout drive, and a the mold plate configured to be driven to reciprocated between a fill and a discharge position. The knockout drive is reciprocating a knockout plunger to discharge molded food products from a cavity in the mold plate, the mold plate being reciprocated by a mold plate drive between a cavity fill position and a cavity discharge position. The machine further includes a manifold connected an outlet of the food pump and having an outlet passageway connected to an inlet of the molding mechanism for filling the cavity of the mold plate. | 2014-03-20 |
20140079843 | SEMI-SOLID ANIMAL FEED BLOCKS AND METHOD OF MAKING AND USING SAME - A semi-solid animal feed block is provided to an animal as a feed supplement or as a complete feed. The feed block is formed of a liquid binder containing denatured wheat flour protein and sugar, and a nutrient mixture of at least one animal feed component. The denatured protein and the sugar bind the nutrient mixture to form the semi-solid animal feed block as a single mass. The nutrients may be formulated to promote digestive tract development of a recently weaned livestock animal, such as a piglet. | 2014-03-20 |