11th week of 2012 patent applcation highlights part 44 |
Patent application number | Title | Published |
20120064553 | BLOOD COAGULATION TIME PROLONGING AGENT - Provided is a reagent, which prolongs a blood coagulation time sufficiently and enhances an optical change, thereby enabling a correct and high-sensitive blood coagulability test. The present invention provides a blood coagulation time prolonging agent, including, as an active ingredient, a guanidine compound represented by the following formula (1) or an acid addition salt thereof (in the formula, R | 2012-03-15 |
20120064554 | METHODS FOR ASSAYING ENZYME ACTIVITIES - The present invention provides compounds and methods for assaying activities of enzymes such as histone deacetylases and histone acetyltransferases. In some embodiments, the methods may be performed in one step. The compounds described herein features peptide-based compounds having at least one blocked lysine or arginine residue which are coupled to reporter moieties. The methods described herein involve reacting a compound described herein with an enzyme, such as a histone deacetylase enzyme or a histone acetyltransferase enzyme, and an endopeptidase that recognizes basic amino acids to release the reporter moiety which may be subsequently detected. | 2012-03-15 |
20120064555 | QUANTITATIVE ANALYSIS OF A BIOLOGICAL SAMPLE OF UNKNOWN QUANTITY - Disclosed is a method for testing a modified specimen such as a dried blood spot, plasma or serum specimen, for an analyte of interest, such as cholesterol. In accordance with the disclosed subject matter, the level of the analyte of interest in the medium from which the modified specimen was obtained (e.g., from a patient's blood) is determined based on the level of an analyte in a solution formed from the modified specimen and on the level of at least one normalizing analyte. The analyte and normalizing analyte each may be an ion, compound, biochemical entity, or property of the specimen. Also disclosed are a fluid collector and a fluid collection device. | 2012-03-15 |
20120064556 | LIPOPROTEIN LIPASE ASSAY - The present invention is directed to a method and kit for the measurement of LPL. The method comprises the following steps; administering a dosage of an anti-coagulant to the subject, gathering the biological sample, adding the biological sample to a well of a well plate, adding a first buffer to the well plate, adding a second buffer to the well plate, adding a substrate to the well plate, incubating the well plate, measuring the fluorescence of the material within the well plate, and correlating the measured fluorescence to a level of LPL activity. The kit comprises the following elements; an anti-coagulant, a well plate, a first buffer, a second buffer, a substrate, and a correlator. | 2012-03-15 |
20120064557 | METHOD OF IDENTIFYING METALLO-BETA-LACTAMASE-PRODUCING BACTERIA - An object of the present invention is to provide a method of identifying metallo-β-lactamase-producing bacteria, particularly, a method of conveniently identifying an IMP or VIM type. According to the present invention, there is provided a method of detecting metallo-β-lactamase-producing bacteria, comprising spotting a compound (I) onto a surface of a solid medium coated with the bacteria to be tested, spotting 3 types of β-lactam agents at 3 respective positions different from the spot of the compound (I), culturing the solid medium, and then detecting the metallo-β-lactamase-producing bacteria based on the shape of an inhibition zone formed around the spot of each of the β-lactam agents. There is further provided a method of identifying an IMP or VIM type of the metallo-β-lactamase-producing bacteria. | 2012-03-15 |
20120064558 | Assays for Differentiating between Ischemic and Hemorrhagic Stroke in a Human Patient - Methods are disclosed for rapidly and reliably differentiating between ischemic and hemorrhagic stroke events in a human patient. The methods include obtaining a biological sample, such as blood serum, and analyzing the sample or a derivative thereof by mass spectrometry to measure the amount of one or more targeted proteins differentially present and ischemic and hemorrhagic stroke patients. The analysis may include proteolytic digestion of the biological sample and selective reaction monitoring (SRM) tandem mass spectrometry of the digested sample to determine the amounts of surrogate peptides corresponding to the targeted proteins. | 2012-03-15 |
20120064559 | TEST ELEMENT, TEST KIT, TEST DEVICE, AND TEST METHOD - According to one embodiment, a test element includes a base, a pair of optical element units, an optical waveguide unit, a detection unit and a holding unit. The base has transparency. The pair of optical element units are arranged away from each other on a major surface of the base. The optical waveguide unit is provided on the major surface of the base. The detection unit is provided on a major surface of the optical waveguide unit of between the optical element units. The major surface of the optical waveguide unit is an opposite side which touches the base. The holding unit is in a frame shape, and one end of the holding unit being is provided to protrude from a major surface of the detection unit. The detection unit includes a color former and a film-formed body holding the color former. | 2012-03-15 |
20120064560 | FOLDING OF RECOMBINANT PROTEINS VIA CO-EXPRESSION OF ARCHAEAL CHAPERONES - The present invention relates to recombinant protein production, and more specifically, to methods for recovery of properly folder bioactive proteins by expressing chaperone genes from extremophilic Archaea, during recombinant protein synthesis in a host cell thereby significantly improving recovery of properly folded bioactive proteins. | 2012-03-15 |
20120064561 | ACTIVITY OF FE-S CLUSTER REQUIRING PROTEINS - The present invention is related to a recombinant host cell, in particular a yeast cell, comprising a dihydroxy-acid dehydratase polypeptide. The invention is also related to a recombinant host cell having increased specific activity of the dihydroxy-acid dehydratase polypeptide as a result of increased expression of the polypeptide, modulation of the Fe—S cluster biosynthesis of the cell, or a combination thereof. The present invention also includes methods of using the host cells, as well as, methods for identifying polypeptides that increase the flux in an Fe—S cluster biosynthesis pathway in a host cell. | 2012-03-15 |
20120064562 | Subterranean Alternating Digester System and Method - An alternating anaerobic and aerobic digestion system and method of forming same includes a subterranean enclosure configured to hold organic matter. The enclosure has a plurality of conduits in a bottom surface of the enclosure. The digestion system further includes an irrigation system configured to dispense a liquid from a top portion of the enclosure and to recover a percolated liquid from a bottom portion of the enclosure, a ventilation system configured to provide air flow to the bottom portion of the enclosure, and a gas-tight membrane cover configured to cover the enclosure. | 2012-03-15 |
20120064563 | CELL-BASED SENSING SYSTEMS AND METHODS - The present disclosure describes cell-based sensors. Cell-based sensors can comprise cells coupled with a sensor for sensing change of configuration and/or movement of the cells. Such changes of configuration and/or movement of the cells can be sensed through changes to one or more parameters such as electrical, mechanical and/or optical parameters. By way of example, the sensors can be magnetic based sensors or electrochemical sensors. | 2012-03-15 |
20120064564 | MICROPLATE-READER WITH A CONTROLLED GAS ATMOSPHERE, CORRESPONDING METHOD AND USE OF SAME - A microplate reader and method has at least one measuring device and a holding device for accommodating at least one microplate and for positioning samples-containing wells of microplates in relation to the measuring device. The at least one measuring device is used for detecting light emitted by samples in wells of a microplate and/or which is influenced by samples transilluminated by light in the wells. The microplate reader has a control unit for controlling the composition of a gas atmosphere surrounding the wells containing the samples. A respective use is characterized particularly in that living cells are measured in a controlled gas atmosphere, wherein the living cells are chosen from microaerophilic, optionally anaerobic and obligatorily anaerobic microorganisms as well as fungi and eukaryotic cells. | 2012-03-15 |
20120064565 | System Setup For Biological Methane Potential Test - A system setup is disclosed for carrying out a biological methane potential test on a biosample and a system setup is disclosed for measuring biomethane gas in a biogas flow. In at least one embodiment, the system setups include at least one container for chemical irreversible fixation of other gases than biomethane gas, the other gases including at least CO | 2012-03-15 |
20120064566 | MULTIPLE PHASE FLOW SYSTEM FOR DETECTING AND ISOLATING SUBSTANCES - A multiple flow system and method for detecting substances in a fluid is provided. More specifically, a first fluid tube containing a first fluid and a second fluid tube containing a second fluid are coupled to a common fluid tube via a connector, such that alternating discrete compartments of the first fluid and the second fluid flow through the common fluid tube. The first and second fluids are immiscible. A substance detector, having a flow chamber with an internal wall, is coupled to the common fluid tube. The alternating discrete compartments of the first and second fluids flow through the flow chamber and are analyzed by the substance detector. | 2012-03-15 |
20120064567 | ACTIVE MICRO SIEVE AND METHODS FOR BIOLOGICAL APPLICATIONS - An active sieve device for the isolation and characterization of bio-analytes is provided, comprising a substrate for supporting the bio-analytes. The substrate comprises a plurality of interconnections and a plurality of regions, each region comprising a hole and at least one electrode embedded in or located on the substrate and electrically associated with the hole. Each region further comprises at least one transistor integrated in the substrate and operably connected to the at least one electrode and to at least one of the plurality of interconnections. | 2012-03-15 |
20120064568 | ENDOMANNOSIDASES IN THE MODIFICATION OF GLYCOPROTEINS IN EUKARYOTES - The present invention generally relates to methods of modifying the glycosylation structures of recombinant proteins expressed in fungi or other lower eukaryotes, to more closely resemble the glycosylation of proteins from higher mammals, in particular humans. The present invention also relates to novel enzymes and, nucleic acids encoding them and, hosts engineered to express the enzymes, methods for producing modified glycoproteins in hosts and modified glycoproteins so produced. | 2012-03-15 |
20120064569 | PRODUCTION OF ATTENUATED NEGATIVE STRANDED RNA VIRUS VACCINES FROM CLONED NUCLEOTIDE SEQUENCES - Attenuated, recombinant negative stranded RNA viruses suitable for vaccine use are produced from one or more isolated polynucleotide molecules encoding the virus. A recombinant genome or antigenome of the subject virus is modified to encode a mutation within a recombinant protein of the virus at one or more amino acid positions(s) corresponding to a site of an attenuating mutation in a heretologous, mutant negative stranded RNA virus. A similar attenuating mutation as identified in the heterologous negative stranded RNA virus is thus incorporated at a corresponding site within the recombinant virus to confer an attenuated phenotype on the recombinant virus. The attenuating mutation incorporated in the recombinant virus may be identical or conservative in relation to the attenuating mutation identified in the heterologous, mutant virus. By the transfer of mutations into recombinant negative stranded RNA viruses in this matter, candidate vaccine viruses are engineered to elicit a desired immune response against a subject virus in a host susceptible to infection thereby. | 2012-03-15 |
20120064570 | NOVEL CELL PENETRATING PEPTIDE - According to the present invention, it is possible to provide a novel cell penetrating peptide that transports proteins into cells and/or into nuclei at higher frequency than conventional cell penetrating peptides, and a pharmaceutical containing the peptide. | 2012-03-15 |
20120064571 | ZCYTOR19 POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES AND METHODS OF USE - Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36.11, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto. | 2012-03-15 |
20120064572 | Bacterial Virulence Factors And Uses Thereof - The invention relates to, in part, secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention provides in part several new common secreted proteins for A/E pathogens. In some embodiments of the invention, these polypeptides and nucleic acid molecules encoding these polypeptides, or portions thereof, are useful as vaccines, diagnostics, or drug screening tools for A/E pathogenic infections, or as reagents. | 2012-03-15 |
20120064573 | METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES - The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins. | 2012-03-15 |
20120064574 | METHOD FOR CONVERTING LIGNOCELLULOSIC BIOMASS - The present invention aims to develop a pretreatment technology for performing efficient saccharification without losing carbohydrates (in particular, free carbohydrates, starch, xylan, or the like) due to solid-liquid separation and washing steps, as a pretreatment for enzymatic saccharification of a lignocellulosic biomass feedstock (including a lignocellulosic biomass feedstock containing readily degradable carbohydrates). Provided are: a production method for a slurry to be used as a substrate for an enzymatic saccharification reaction, comprising: pulverizing an aerial part of a plant as a lignocellulosic biomass feedstock; preparing a slurry containing the biomass feedstock, calcium hydroxide, and water; subjecting the slurry to an alkali treatment; and neutralizing the slurry by introduction of and/or pressurization with carbon dioxide to decrease a pH to 5 to 7; an enzymatic saccharification method, comprising using, as a substrate, a slurry obtained by the production method for a slurry; and a production method for ethanol, comprising using, as a substrate, a saccharification product obtained by the enzymatic saccharification method. | 2012-03-15 |
20120064575 | CHEMO-ENZYMATIC APPROACH TO THE SYNTHESIS OF PIMECROLIMUS - Processes for preparing pimecrolimus starting from ascomycin, exploiting the selectivity characteristics of the purified enzymatic systems particularly regarding the selective functionalization of the hydroxyl groups present in position 24 and 33 of ascomycin. Such method represents the first example of chemoenzymatic synthesis for preparing pimecrolimus. | 2012-03-15 |
20120064576 | METHOD AND COMPOSITION FOR ENHANCING EFFICIENCY AND SENSITIVITY IN POLYMERASE CHAIN REACTION - Methods and compositions for enhancing reaction efficiency and sensitivity in polymerase chain reaction (PCR) are disclosed. | 2012-03-15 |
20120064577 | Mutant T7 polymerases - Provided are mutant polymerases that comprise a deletion of at least four amino acids among the amino acids at positions corresponding to 167-174 of SEQ ID NO:1. Also provided are mutant polymerases having greater resistance to 30 mM NaCl, 7.5 mM phosphate, or 20 μg/ml single stranded DNA than a wild-type T7 RNA polymerase having SEQ ID NO:1 or a wild-type T3 RNA polymerase having SEQ ID NO:3. Nucleic acids comprising a nucleotide sequence encoding any of the above mutant polymerases are also provided, as are vectors comprising those nucleic acids and host cells transformed with the vectors Additionally, methods of amplifying mRNA using the mutant polymerases described herein are also provided. Further, compositions comprising any of the mutant polymerases described herein, and a reagent at a concentration that is inhibitory to wild-type T7 RNA polymerase is provided. | 2012-03-15 |
20120064578 | CHROMOSOME-BASED PLATFORMS - Artificial chromosomes, including ACes, that have been engineered to contain available sites for site-specific, recombination-directed integration of DNA of interest are provided. These artificial chromosomes provide tractable, efficient and rational engineering of the chromosome for a variety of applications. | 2012-03-15 |
20120064579 | Altering Enzyme Balance Through Fermentation Conditions - This present disclosure relates to methods for improved production of proteins from a cell culture, particularly to culture components and conditions that can preferentially increase the expression of proteins produced from genes under the control of xylanase gene promoter sequences. The improved methods can be used for the production of enzyme compositions with enhanced xylanase and hemicellulolytic activity. | 2012-03-15 |
20120064580 | TERMITE ENZYMES AND USES THEREOF FOR IN VITRO CONVERSION OF LIGNIN-CONTAINING MATERIALS TO FERMENTABLE PRODUCTS - The disclosure provides isolated nucleic acid molecules derived from the gut of the termite | 2012-03-15 |
20120064581 | ESCHERICHIA COLI METABOLIC ENGINEERING OXYGEN INDEPENDENT PLATFORM STRAINS AND METHODS OF USE THEREOF - The invention provides transgenic | 2012-03-15 |
20120064582 | Nucleotide Sequences Encoding Alanine Racemase from Coryneform - The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the alr gene, and a host-vector system having a coryneform host bacterium in which the alr gene is present in attenuated form and a vector which carries at least the alr gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes. | 2012-03-15 |
20120064583 | HIGH THROUGHPUT BIOPROCESS APPARATUS - The invention relates to a multiple bioreactor system comprising a plurality of bioreactors, a source of pressurised fluid, and distribution means for distributing the fluid to the bioreactors, wherein the bioreactor system includes backpressure creating means presented by, before or after each bioreactor and the source of pressurised fluid such that each backpressure creating means provides a resistance to the flow of the pressurised fluid which is greater than the resistance to flow between each backpressure creating means. The invention further relates to A method of operating a multiple bioreactor system comprising providing a plurality of bioreactors, a source of pressurised fluid, and distribution means for distributing the fluid to the bioreactors, wherein the bioreactor system includes backpressure creating means presented by each bioreactor or located between each bioreactor and the source of pressurised fluid such that each backpressure creating means provides a resistance to the flow of the pressurised fluid which is greater than the resistance to flow between each backpressure creating means and operating the system. | 2012-03-15 |
20120064584 | BUFFER COMPOSITION FOR CATALYZING THE PREPARATION OF CALCITRIOL OR CALCIFEDIOL AND METHOD FOR PREPARING CALCITRIOL OR CALCIFEDIOL USING SAME - The present invention relates to a buffer composition for promoting production of calcitriol or calcifediol, and a method for producing calcitriol or calcifediol using the same. More particularly, the present invention relates to a buffer composition for promoting production of calcitriol or calcifediol comprising a metallic compound, an organic solvent, cyclodextrin, tris(hydroxymethyl)aminomethane, sodium succinate, sodium chloride, magnesium chloride, and water, and a method for producing calcitriol or calcifediol using the same. In the method for producing calcitiriol or calcifediol, the production yield of calcitriol or calcifediol is high, and the bioconversion is carried out in an enzyme reaction system instead of in a microorganism culture system. Thus, it is not required to maintain a sterile state. Also, the separation/purification following the completion of a biocatalytic reaction can be carried out in a cleaner state than the microorganism culture method. Accordingly, there is an advantage in that a cost required for separation is low and the quality is improved. Furthermore, the buffer composition for promoting production of calcitriol or calcifediol can provide a high productivity of calcitriol or calcifediol. | 2012-03-15 |
20120064585 | Increased Heterologous Fe-S Enzyme Activity in Yeast - Yeast strains were engineered that have increased activity of heterologous proteins that require binding of an Fe—S cluster for their activity. The yeast strains have reduced activity of an endogenous Fe—S protein. Activities of heterologous fungal or plant 2Fe-2S dihydroxy-acid dehydratases and Fe—S propanediol dehydratase reactivase were increased for increased production of products made using biosynthetic pathways including these enzymes, such as valine, isoleucine, leucine, pantothenic acid (vitamin B5), isobutanol, 2-butanone and 2-butanol. | 2012-03-15 |
20120064586 | Multimeric Oxidoreductases - The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof. | 2012-03-15 |
20120064587 | RECOMBINANT CLOSTRIDIA THAT FIX CO2 AND CO AND USES THEREOF - The present invention relates a recombinant | 2012-03-15 |
20120064588 | PROTEIN COMPLEX HAVING ACTIVITY CATALYZING ASYMMETRIC OXIDATION REACTION AND PROCESS FOR PRODUCING THE SAME - A process for producing a cross-linked crystallized protein complex, which comprises: a first step of concentrating a crude protein derived from an animal or plant; a second step of encapsulating the protein in a gel, to thereby allow the protein to undergo air oxidation, and then extracting a protein complex from the gel; a third step of allowing the extracted protein complex to undergo crystallization and precipitation; and a fourth step of cross-linking the precipitated protein complex. Alternatively, by use of a fifth step of drying (FD) the obtained crosslinked crystallized protein complex, to thereby form a powder. As a result, there is provided an enzyme which is stable at room temperature storage, and has an activity in catalyzing an asymmetric oxidation reaction. That is, there is provided a useful material which enables an efficient enzyme-mimetic reaction under a mild condition. | 2012-03-15 |
20120064589 | ENERGY PHOTOCONVERTER FOR OBTAINING BIOFUELS - The present invention relates to the design of energy photoconverters which act in a continuous and closed manner for producing biofuels and other products of interest by means of the mass culturing of phytoplankton. | 2012-03-15 |
20120064590 | RECOVERY OF HIGHER ALCOHOLS FROM DILUTE AQUEOUS SOLUTIONS - This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs. | 2012-03-15 |
20120064591 | RECOMBINANT YEAST WITH IMPROVED ETHANOL TOLERANCE AND RELATED METHODS OF USE - The present invention provides isolated Elo1 and Mig3 nucleic acid sequences capable of conferring increased ethanol tolerance on recombinant yeast and methods of using same in biofuel production, particularly ethanol production. Methods of bioengineering yeast using the Elo1 and, or, Mig3 nucleic acid sequences are also provided. | 2012-03-15 |
20120064592 | BIOCATALYSTS SYNTHESIZING DEREGULATED CELLULASES - Provided are isolated novel | 2012-03-15 |
20120064593 | SUPERANTIBODY SYNTHESIS AND USE IN DETECTION, PREVENTION AND TREATMENT OF DISEASE - Superantibodies having enhanced autophilic, catalytic, and/or membrane-penetrating properties are prepared by affinity-based conjugation of a photoactivatable organic molecule to a target immunoglobulin. The photoactivatable organic molecule bears a chromophoric aromatic hydrocarbon moiety, which has affinity for the immunoglobulin. Upon photolysis, the organic molecule is covalently linked to the immunoglobulin. A preferred organic molecule is a peptide and a preferred aromatic hydrocarbon moiety is a tryptophan residue. The photoactivatable organic molecule need not bear a purine, pyrimidine or azido group to effect binding to the immunoglobulin and/or photoactivation. Autophilic superantibodies can promote apoptosis of target cells and/or enhance therapeutic efficacies in the treatment of patients with diseases or disorders responsive to antibody therapy. Exemplary of such diseases are atherosclerosis and cardiovascular disease. Membrane-penetrating superantibodies can prevent apoptosis by binding to intracellular anti-caspase signal proteins. Compositions containing the superantibodies, as well as methods of making and using them, are disclosed. | 2012-03-15 |
20120064594 | DEVICE AND METHOD FOR TREATING CELLS - The present invention relates to a device for treating biological cells in an object, the device comprising: —a single winding coil element; —an electrical generator connected to the single winding coil element, the single winding being configured to be positioned essentially around the object; wherein the electrical generator is configured to discharge into the single winding coil element so that the single winding coil element generates a short duration pulsed electromagnetic field by magnetic induction in the single winding coil element, the electromagnetic field having a field strength that is sufficiently high to affect, preferably increase the permeability of cell membranes and/or intracellular membranes of the biological cells contained in the object when in operation the object is placed inside the single winding coil element. | 2012-03-15 |
20120064595 | Method for accumulating cells - The present invention has as an object to simplify the implant work in a series of the process from the separation of target cells by dielectrophresis to the cell cultivation and to realize a cell accumulation method that prevents bacteria contamination by bacteria. | 2012-03-15 |
20120064596 | HIGH-DENSITY SPOT SEEDING FOR TISSUE MODEL FORMATION - A method for making a tissue includes seeding cells at a selected concentration on a support to form a cell spot, incubating the cells to allow the cells to partially attach, rinsing the cells to remove any unattached cells, adding culture medium to enable the cells to proliferate at a periphery of the cell spot and to differentiate toward a center of the cell spot, and further incubating the cells to form the tissue. The cells may be C2C12 cells or other subclones of the C2 cell line, H9c2(2-1) cells, L6 cells, L8 cells, QM7 cells, Sol8 cells, G-7 cells, G-8 cells, other myoblast cells, cells from other tissues, or stem cells. The selected concentration is in a range from about 1×10 | 2012-03-15 |
20120064597 | MICROFLUIDIC MIXING AND ANALYTICAL APPARATUS - Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the sample are enhanced. Such devices provide an alternative for mixing that does not use a vent and can be used with a variety of particles in suspension such as magnetic beads to capture or purify useful cells and molecules. | 2012-03-15 |
20120064598 | Mutation of the parkin gene, compositions, methods and uses - The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes. | 2012-03-15 |
20120064599 | HYBRIDIZATION LINKERS - The invention provides method of covalently coupling two or more moieties, the method comprising: (a) providing a first moiety having covalently attached thereto (i) at least one first linker comprising a first hybridizable region and (ii) at least one first group capable of forming a covalent bond; (b) providing a second moiety having covalently attached thereto (i) at least one second linker comprising a second hybridizable region capable of hybridizing to the first hybridizable region and (ii) at least a second group capable of forming a covalent bond with the first group; (c) contacting the first and second moieties under conditions that allow the first and second hybridizable regions to hybridize and link the moieties; and (d) exposing the linked moieties to conditions that allow the formation of a covalent bond between the first and second groups. | 2012-03-15 |
20120064600 | ANTI-5T4 ANTIBODIES AND USES THEREOF - Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same. | 2012-03-15 |
20120064601 | Chromatography Membranes for the Purification of Chiral Compounds - Described herein are composite materials and methods of using them for the separation or purification of enantiomers. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a macroporous cross-linked gel, comprising a plurality of macropores, and a plurality of pendant chiral moieties. In certain embodiments, the composite materials may be used in the separation or purification of a chiral small molecule. | 2012-03-15 |
20120064602 | DISH DETERGENT COMPRISING BLEACHING ENZYMES - Described are compositions and methods that involve using bleaching enzymes in dish detergents. In some preferred embodiments, the bleaching enzyme comprises at least one laccase, while in some alternative preferred embodiments, the bleaching enzyme comprises at least one glucose oxidase suitable for use in dish detergents. In some additional preferred embodiments, the dish detergents are machine dish detergents. | 2012-03-15 |
20120064603 | SELECTIVE ACCESS TO CRYOPRESERVED SAMPLES - Methods and apparatus for selectively accessing a portion of a sterile cryopreserved sample are disclosed. The apparatus may include a container configured to receive the cryopreserved sample and having a first portion and a second portion, a heat sink chamber surrounding the first portion of the container, and a heat source adjacent to the second portion of the container. The chamber may be configured to maintain a non-accessed portion of the sample in a cryopreserved state. The heat source may be configured to separating an accessed portion of the sample from the non-accessed portion of the sample while maintaining the viability of the accessed portion while the non-accessed portion is maintained in the cryopreserved state. | 2012-03-15 |
20120064604 | METHODS FOR ENHANCING INFECTIVITY OF RETROVIRUSES - The present invention provides methods for producing retroviruses or viral vectors with enhanced infectivity. The methods entail transfecting a retroviral vector into a packaging cell that has suppressed expression or inhibited enzymatic activity of a parvulin prolyl peptidyl isomerase (parvulin PPIase), and culturing the transfected packaging cell to allow production of viral particles. The invention also provides methods for enhancing efficiency of gene transfer with a recombinant retrovirus. These methods involve constructing a recombinant retroviral vector expressing a target gene, transfecting into a packaging cell that has suppressed expression or inhibited enzymatic activity of a parvulin prolyl peptidyl isomerase (parvulin PPIase), culturing the transfected packaging cell to allow production of recombinant retroviral particles, harvesting recombinant retroviral particles from supernatant of the cultured cell, and transducing the recombinant retroviral particles into a target cell. Kits for carrying out these methods are also provided in the invention. | 2012-03-15 |
20120064605 | Anaerobic Microbial Composition and Methods of Using Same - A microbial composition for concurrent dechlorination of a mixture of chlorinated ethanes and chlorinated ethenes includes a isolated consortium of bioremediative microorganisms comprising strains of microorganism comprising | 2012-03-15 |
20120064606 | METHOD FOR PRODUCING HIGH CONCENTRATE LACTIC ACID BACTERIA WITH MEMBRANE BIOREACTOR AND FREEZE-DRIED, LACTIC ACID BACTERIA POWDER - The present invention relates to a method for producing lactic acid bacteria of a high concentration continuously using a membrane bioreactor. Specifically, the present invention relates to a method for producing lactic acid bacteria of a high concentration in a membrane bioreactor that comprises the steps of cultivating lactic acid bacteria in a membrane bioreactor including a membrane for product separation and a medium supply apparatus; supplying culture media to the bioreactor through the medium supply apparatus; continuously separating and discharging culture filtrate through the membrane for product separation; and recycling lactic acid bacteria continuously to the bioreactor. Additionally, the present invention relates to a method for producing lactic acid bacteria powder by freeze drying the bacteria produced in the membrane bioreactor using a freeze drying preservative composition. The lactic acid bacteria obtained through the membrane bioreactor is obtained in pellet form with a centrifugal separator, and is subjected to freeze-drying using the composition for freeze drying preservative containing certain amounts of trehalose, maltodextrin, starch and sodium carboxy methyl cellulose to form lactic acid powder. The lactic acid bacteria that have been converted into powder by such method exhibit superior stability chemically and physically compared to lactic acid bacteria powder that has been subjected to simple freeze drying. | 2012-03-15 |
20120064607 | FERMENTATION ON PENTOSE SUGARS - The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence encoding the xylose isomerase confers to the host cell the ability to convert xylose to xylulose which may be further metabolized by the host cell. Thus, the host cell is capable of growth on xylose as carbon source. The host cell preferably is a eukaryotic microorganism such as a yeast or a filamentous fungus. The invention further relates to processes for the production of fermentation products such as ethanol, in which a host cell of the invention uses xylose for growth and for the production of the fermentation product. The invention further relates to nucleic acid sequences encoding eukaryotic xylose isomerases and xylulose kinases as obtainable from anaerobic fungi. | 2012-03-15 |
20120064608 | METHOD OF CULTURING PHOTOSYNTHETIC ORGANISMS - The present invention provides cultivation chambers and methods for the cultivation of photosynthetic organisms, particularly algae. | 2012-03-15 |
20120064609 | SOLUBILIZATION OF COAL OR LIGNOCELLULOSE BIOMASS - The present methods deal with the solubilization of coal and lignocellulose biomass using pyrophosphates, polyphosphates, or derivatives thereof. | 2012-03-15 |
20120064610 | SOLVENT AND METHOD FOR CO2 CAPTURE FROM FLUE GAS - The present disclosure describes the efficient use of a catalyst, an enzyme for example, to provide suitable real cyclic capacity to a solvent otherwise limited by its ability to absorb and maintain a high concentration of CO | 2012-03-15 |
20120064611 | Process For The Preparation of (3R)-Hydroxybutyl (3R) -Hydroxybutyrate By Enzymatic Enantioselective Reduction Employing Lactobacillus Brevis Alcohol Dehydrogenase - A process for producing a compound which is (3R)-hydroxybutyl(3R)-hydroxybutyrate of formula (I) which process comprises submitting, to enantioselective reduction, a compound of the following formula (II), (III) or (IV). | 2012-03-15 |
20120064612 | MICROFLUIDIC DEVICES FOR FLUID MANIPULATION AND ANALYSIS - The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis. | 2012-03-15 |
20120064613 | Monitoring Methods and Apparatus - A device for remote management of patients suffering from heart failure and hypertension can measure one or more biomarker. The device aids in monitoring the efficacy and safety of treatment in such patients. | 2012-03-15 |
20120064614 | DEVICE FOR PREPARING AND/OR TREATING A BIOLOGICAL SAMPLE - The invention relates to a device for preparing and/or treating a biological sample including an assembly ( | 2012-03-15 |
20120064615 | TEST ELEMENT FOR DETECTING AN ANALYTE IN A SAMPLE - The invention relates to a test element for detecting at least one analyte in a sample, in particular for detecting at least one metabolite in a bodily fluid. The test element comprises at least one test field with a test field surface. The test field comprises at least one detection reagent that is adapted to undergo a detectable reaction in the presence of the analyte. The test element further comprises at least one distribution element that has at least one distribution surface facing the test field surface. Between the distribution surface and the test field surface is at least one capillary gap, wherein the capillary gap is adapted to allow a layer of the sample with a layer thickness of no more than 50 μm to form within the capillary gap. | 2012-03-15 |
20120064616 | DEVICE FOR MEASURING AN ULTRA LOW GAS FLOW - A measuring device is disclosed for measuring an ultra low gas flow, working by the principle of liquid displacement. In at least one embodiment, the measuring device includes at least one cell including a gas inflow device, a gas compartment device with a predefined inner geometric physical volume and active volume. In at least one embodiment, the gas compartment device includes one gas accumulating end and one lifting end, the gas compartment device also defining a geometric gas collecting point inside of the gas compartment device, during a gas filling cycle, the geometric gas collecting point moving further and further from the gas accumulating end to the lifting end during the gas filling cycle. Further, in at least one embodiment the cell includes a holding device having a pivoting element enabling the gas compartment device to pivot upwards when the geometric gas collecting point is positioned at the lifting end and the lifting force is larger than the down-pressing force at the lifting end, thereby releasing all of the accumulated gas in the gas compartment device, and then pivoting back to its initial standby position for new receipt and storage of gas during another gas filling cycle until next releasing sequence. Finally, in at least one embodiment, the cell also includes a sensor provided to generate a signal and/or change the state of a signal when the gas compartment device is not in its initial standby position, wherein the gas storing capacity of the inside of the gas compartment device is larger at the gas accumulating end than at the lifting end and wherein the gas accumulating end has a higher vertical position than the lifting end at the initial standby position. | 2012-03-15 |
20120064617 | SYSTEM AND METHOD FOR CONTINUOUS FERMENTATION OF ALGAE - The present invention is a method for fermentation of algae or algaefaction method. The method includes feeding a hydrocarbon composition into a gasifier and pre-heating a biomass stream from a fermentation reactor. The biomass stream includes a liquid portion, a catalyst, and a biomass solids portion ranging between 15-92% by weight of the biomass stream. The biomass solids portion is algae or algal solids. The biomass stream is pre-heated to a temperature range between 200° F. and 500° F. Both the syngas and the pre-heated biomass stream are injected as a mixture into a reactor, where the mixture is separated into a gas component, liquid component, and solids component. The solids component is algal crude, which can be collected for processing as transportation fuels. The gas component is a lower temperature syngas, which can also be collected for processing as electricity or transportation fuels. | 2012-03-15 |
20120064618 | Compost Tea Apparatus - An apparatus and method of producing compost tea with an elongated container having a vortex chamber, cylindrical screen, and outlet wherein compost is placed inside the vortex chamber, nozzles spray water into the compost chamber under pressure forcing nutrients and micro-organisms from the compost into the water which passes through the screen and out of the outlet into a holding tank. | 2012-03-15 |
20120064619 | Device for the Anaerobic Fermentation of Organic Material - A device for implementing anaerobic fermentation having a vertically standing fermentation tank with a fermentation chamber in which organic material can be fermented, a feed device to mix fresh organic material with inoculant and to carry it through to an inlet in the fermentation tank, which is also provided with a cone with an extraction outlet via which fermented material can be discharged and an outlet for biogas, where the device is also provided with two or more return openings via which a fraction of the partly fermented material, located between the inlet and the outlet, is removed from the fermentation tank and is carried up through feed lines between the mixing pump and the inlet that are situated partly and vertically in the fermentation tank. | 2012-03-15 |
20120064620 | MODULAR DNA-BINDING DOMAINS AND METHODS OF USE - The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in a DNA sequence and, to DNA which is modified so that it can be specifically recognized by a polypeptide and to uses of the polypeptide and DNA in specific DNA targeting as well as to methods of modulating expression of target genes in a cell. | 2012-03-15 |
20120064621 | Cell Culture Compositions Capable of Producing a VEGF-Binding Fusion Polypeptide - The present invention provided cell culture compositions capable of producing fusion polypeptides that bind vascular endothelial growth factor (VEGF). The cell culture compositions of the invention comprise cells which contain an expression vector comprising a nucleic acid molecule encoding a fusion polypeptide that binds VEGF. The fusion polypeptides may comprise a VEGF receptor component having immunoglobulin-like (Ig) domain 2 of a first VEGF receptor, an Ig domain 3 of a second VEGF receptor, and a multimerizing component. | 2012-03-15 |
20120064622 | Methods and Systems for Chemoautotrophic Production of Organic Compounds - The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest. | 2012-03-15 |
20120064623 | Process for the Culturing of Cells - The invention relates to a process for the culturing of cells, preferably El-immortalized HER cells, more preferably PER.C6 cells in a reactor in suspension in a cell culture medium, wherein the cells produce a biological substance, preferably an antibody, wherein at least one cell culture medium component is fed to the cell culture and wherein the cell culture comprising the cells, the biological substance and cell culture medium is circulated over a separation system and wherein the separation system separates the biological substance from substances having a lower molecular weight than the biological substance and wherein the biological substance is retained in or fed back into the reactor. Preferably part of the substances of lower molecular weight is continuously removed from the cell culture. | 2012-03-15 |
20120064624 | METHOD FOR INHIBITING THE GROWTH OF MYCOBACTERIUM TUBERCULOSIS BY USING CD13 RECEPTOR - The present invention discloses a method for inhibiting the growth of | 2012-03-15 |
20120064625 | Nucleic Acids, Polypeptides, Compositions, and Methods for Modulating Apoptosis - The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods. | 2012-03-15 |
20120064626 | B7-H7 ANTIBODIES AND METHOD OF USE - The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides. | 2012-03-15 |
20120064627 | APPARATUS AND METHOD FOR CULTURING STEM CELLS - A method is provided to prepare a plurality of microwells suitable for the formation of embryoid bodies from embryonic stem cells. The method requires applying an image-forming material to a heat sensitive thermoplastic material in a designed pattern and heating the material under conditions that reduce the size of the receptive material by at least about 60% to create a mold. A polymer such as PDMS is then applied to the mold and removed to form the microwells. In an alternative aspect, the plurality of microwells on receptive material are prepared by etching a microwell designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the receptive material by at least about 60%. | 2012-03-15 |
20120064628 | TUBULAR SCAFFOLD FOR NEURAL GROWTH - A scaffold for neurons consists of tubes sized to promote neural growth through the tubes. The tubes may be fixed to a substrate providing electrical or optical paths out from the interior of the tubes from sensors or stimulating probes at one or more locations along the length of the coaxial axons. Steering electrodes at spaces between tubes may be used to selectively promote the growth of interconnections of different axons in a one, two, or three-dimensional fashion. | 2012-03-15 |
20120064629 | VARIANT ISOPRENOID PRODUCING ENZYMES AND USES THEREOF - This disclosure provides methods of designing and generating polypeptide variants that have altered properties compared to a parent polypeptide. The present disclosure provides methods of generating polypeptide variants, for example, variant isoprenoid synthases and/or variant prenyl transferases that have at least one desired property not present in the parent polypeptide. The present disclosure further provides polypeptides and polynucleotides encoding variant polypeptides, as well as vectors and host cells comprising the polynucleotides that encode the variant polypeptides. In other embodiments, the present disclosure provides methods of using the variant polypeptides to generate useful products, such as isoprenoid compounds and/or isoprenoid products. | 2012-03-15 |
20120064630 | EUKARYOTIC HOST CELL COMPRISING AN EXPRESSION ENHANCER - Invention relates to a eukaryotic host cell comprising a recombinant nucleotide sequence encoding an expression enhancer, which is selected from the group consisting of cLC52, RPL33 and cLC61, and its use in a method of producing a protein of interest (POI). | 2012-03-15 |
20120064631 | METHOD FOR AMPLIFICATION AND HIGH-LEVEL EXPRESSION OF TARGET GENE IN MAMMALIAN CELL, AND KIT FOR ACHIEVING THE METHOD - The present invention provides novel means for amplifying a target gene outside a chromosome of the mammalian cell with a high probability in amplifying a target gene with use of IR/MAR plasmid, to further improve a high-level gene amplification system. The present invention is a method of amplifying a target gene outside a chromosome of a mammalian cell, and includes the step of transferring, concurrently to a mammalian cell, (i) a vector including (a) a mammalian replication initiation region functioning in a mammalian cell and (b) a nuclear matrix attachment region functioning in a mammalian cell, (ii) a target gene, and (iii) a polynucleotide including a telomere repetitive sequence. | 2012-03-15 |
20120064632 | ELECTRO-CHEMICAL SENSOR - The present invention provides an electrochemical sensor having a solid electrically conductive substrate and a compound immobilized thereon which has binding affinity for an analyte species to be detected and also displays electrochemical behaviour which is modified upon binding of that analyte species, so that binding of an analyte species can be detected by measuring electrochemical properties, such as by voltammetry. Desirably the immobilised compound contains both a first moiety with binding affinity for the analyte and a separate second moiety which is a redox system whose electrochemical oxidation/reduction properties become modified when the first moiety binds the analyte. The analyte binding moiety may be a diol or polyol and preferably is a sugar. The electrochemical sensor finds use in methods of analysing reservoir and process fluids, particularly at a subterranean location. The electrochemical sensor may be a component of a downhole tool, adapted for deployment downhole. | 2012-03-15 |
20120064633 | FLUORESCENCE QUENCHING AZO DYES, THEIR METHODS OF PREPARATION AND USE - Disclosed is a group of azo quencher compositions useful as fluorescence quenchers having the general structure of formula 1, methods of making or using the compositions, and kits comprising the composition. | 2012-03-15 |
20120064634 | Chromium-Free Indicating Device for Chloride Detection - A chemical indicating device ( | 2012-03-15 |
20120064635 | ENERGY METER FOR MIXED STREAMS OF COMBUSTIBLE COMPOUNDS - An energy content meter can spectroscopically quantify oxidation products after oxidation of a combustible mixture. The measured oxidation product concentrations or mole fractions can be converted to an energy content of the un-oxidized combustible mixture using a conversion factor that relates oxygen consumption during oxidation of the combustible mixture to the energy content of the combustible mixture. | 2012-03-15 |
20120064636 | AUTOMATIC ANALYSIS DEVICE AND ANALYSIS METHOD - Provided are an automated analyzer and an automatic analysis method for highly accurately determining presence or absence of abnormality based on reaction process data obtained when concentration of a chemical component or an activity level of an enzyme is measured. The reaction process data is approximated by a function, and shape feature quantities indicating features of a shape of a curve section at an early stage of reaction are calculated. The obtained shape feature quantities are used to determine the presence or absence of abnormality. | 2012-03-15 |
20120064637 | PREWETTING LATERAL FLOW TEST STRIP - A test strip and method for detecting an analyte present in a sample. The test strip comprising: a buffer addition zone to which a buffer may be added; an absorbent zone proximal to the buffer addition zone; one or more test zones distal to the buffer addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; a terminal buffer flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the buffer addition zone and having an absorption capacity relative to the other zones of the test strip such that when a volume of buffer within a predetermined buffer volume range for the test strip is added to the buffer addition zone, a distal diffusion front of the buffer diffuses from the buffer addition zone to a distal diffusion point within the terminal buffer flow zone and then diffuses proximal relative to the one or more test zones; and a sample addition zone distal to the terminal buffer flow zone to which a sample may be added. | 2012-03-15 |
20120064638 | SAMPLE PROCESSING APPARATUS AND SAMPLE PROCESSING METHOD - A sample processing apparatus for performing a process including a plurality of steps on a sample, the sample processing apparatus sequentially processing a plurality of samples, is disclosed. The apparatus comprises a plurality of units corresponding to the respective steps in the process; a transfer section which transfers a sample to the units according to a flow of the steps; and a controller. Specifically, when an operation was not performed successfully, the controller interrupts the process for a sample that had not reached the location where the unsuccessful operation was performed while continuing the process for a sample that had already passed the location, retries the operation that was not performed successfully, and resumes the interrupted process when the retried operation has been performed successfully. | 2012-03-15 |
20120064639 | STABLE ELASTOMERIC NEGATIVE ACOUSTIC CONTRAST PARTICLES AND THEIR USE IN ACOUSTIC RADIATION FIELDS - We describe methods for synthesis and formulations of stable elastomeric negative acoustic contrast particles with controllable compressibility and density. These elastomeric negative acoustic contrast particles have a density/compressibility ratio that is less than that of water and therefore exhibit negative acoustic contrast under acoustic radiation exposure. This negative acoustic contrast allows our elastomeric negative acoustic contrast particles to be acoustically manipulated (e.g. separated) differently from other components (e.g. cells) within an aqueous solution. This disclosure also describes methods for biofunctionalization of the elastomeric negative acoustic contrast particles and as an example their use as platforms for bioassays. Potential applications of these elastomeric negative acoustic contrast particles include sensitive bioassays based on acoustic flow cytometry and other types of techniques that utilize acoustic fields, including ultrasound imaging and ultrasound triggered drug delivery. | 2012-03-15 |
20120064640 | Spin transfer MRAM device with novel magnetic synthetic free layer - A method of forming a CPP MTJ MRAM element that utilizes transfer of spin angular momentum as a mechanism for changing the magnetic moment direction of a free layer. The device includes a tunneling barrier layer of MgO and a non-magnetic CPP layer of Cu or Cr and utilizes a novel synthetic free layer having three ferromagnetic layers mutually exchange coupled in pairwise configurations. The free layer comprises an inner ferromagnetic and two outer ferromagnetic layers, with the inner layer being ferromagnetically exchange coupled to one outer layer and anti-ferromagnetically exchange coupled to the other outer layer. The ferromagnetic coupling is very strong across an ultra-thin layer of Ta, Hf or Zr of thickness preferably less than 0.4 nm. | 2012-03-15 |
20120064641 | METHOD OF FABRICATING ARRAY SUBSTRATE FOR ORGANIC ELECTROLUMINESCENT DEVICE AND METHOD OF REPAIRING THE SAME - A method of fabricating an organic electroluminescent device (OELD) according to the present invention has steps of repairing a pixel region by irradiating a laser on a drain contact hole of a passivation layer in a pixel region in need of the repair; and disabling the connection between an organic electroluminescent diode and a drain electrode of a driving thin film transistor (TFT), where the pixel region of the OELD has i) the driving TFT comprising the drain electrode, ii) the passivation layer covering the driving TFT, while comprising the drain contact hole exposing the drain electrode of the driving TFT, and iii) the organic electroluminescent diode connected to the drain electrode of the driving TFT via the drain contact hole. | 2012-03-15 |
20120064642 | METHOD TO REMOVE SAPPHIRE SUBSTRATE - A Light-Emitting Diode (LED) is formed on a sapphire substrate that is removed from the LED by grinding and then etching the sapphire substrate. The sapphire substrate is ground first to a first specified thickness using a single abrasive or multiple abrasives. The remaining sapphire substrate is removed by dry etching or wet etching. | 2012-03-15 |
20120064643 | Methods and System for On-Chip Decoder for Array Test - The present invention provides devices capable of testing the electrical performance of thin-film transistor backplane arrays and methods for their use. | 2012-03-15 |
20120064644 | Fluid Ejection Device and Method - A fluid ejection device includes one or more digital data storage arrays having plural EPROM cells. A method for affirming performance adequacy of EPROM cells in the one or more arrays includes the steps of identifying a reference cell in each array, measuring a selected performance criterion for the reference cells, obtaining a reference criterion value, and evaluating the actual performance of at least one cell in each array with respect to the reference criterion value. | 2012-03-15 |
20120064645 | MANUFACTURING METHOD OF SEMICONDUCTOR DEVICE - A method for manufacturing a semiconductor device according to the present invention comprises: forming a semiconductor circuit including a first transistor with a first threshold voltage and a first drain-source current; applying a stress voltage to the first transistor to make at least one of a change from the first threshold voltage a second threshold voltage and a change from the first drain-source current to a second drain-source current; and shipping the semiconductor circuit while the first transistor is presenting one of the second threshold voltage and the second drain-source current. | 2012-03-15 |
20120064646 | METHOD OF MANUFACTURING SEMICONDUCTOR INTEGRATED CIRCUIT DEVICE - The variation in the contact pressures of the plurality of contact terminals to the plurality of chip electrodes is decreased. A thin-film sheet (first sheet) includes: a principal surface (contact-terminal formation surface) on which a plurality of contactors (contact terminals) are formed; and a rear surface positioned on an opposite side to the principal surface. Also, in the thin film sheet, a plurality of wirings and dummy wiring are arranged between the principal surface and the rear surface. A slit formed of an opening portion penetrating from the principal surface of the thin-film sheet to the rear surface thereof is formed along the wiring between the dummy wiring and the contactor arranged at an end of a contactor group (first contact terminal group) in which the plurality of contactors are aligned. | 2012-03-15 |
20120064647 | METHOD OF FABRICATING MICROELECTROMECHANICAL SYSTEMS DEVICES - A method of fabricating microelectromechanical systems devices is disclosed. A silicon substrate having a plurality of microelectromechanical systems elements formed on a first surface thereof is provided. A guard layer defining a plurality of recesses is applied to the silicon substrate such that respective microelectromechanical systems elements are located within respective recesses. The silicon substrate is then segmented into discrete parts and an adhesive layer is bonded to a second surface of the silicon substrate. The guard layer is next segmented into discrete parts corresponding to the discrete parts of the silicon substrate, thereby forming individual microelectromechanical systems devices. Finally, the adhesive layer is selectively exposed to a light source allowing removal of individual microelectromechanical systems devices. | 2012-03-15 |
20120064648 | DISPLAY DEVICE AND MANUFACTURING METHOD OF THE SAME - It is an object of the present invention to provide a method for manufacturing a display device in which unevenness generated under a light-emitting element does not impart an adverse effect on the light-emitting element. It is another object of the invention to provide a method for manufacturing a display device in which penetration of water into the inside of the display device through a film having high moisture permeability can be suppressed without increasing processing steps considerably. A display device of the present invention comprises a thin film transistor and a light-emitting element, the light-emitting element including a light-emitting laminated body interposed between a first electrode and a second electrode; wherein the first electrode is formed over an insulating film formed over the thin film transistor; and wherein a planarizing film is formed in response to the first electrode between the first electrode and the insulating film. | 2012-03-15 |
20120064649 | METHOD OF FORMING AN ALIGNMENT FILM FOR USE IN AN LCD PANEL - The present invention discloses a method of forming an alignment film for use in a liquid crystal display (LCD). The method includes: Provide a glass substrate and dispose an ITO film on the glass substrate. Next, set the thickness of the alignment film. Next, determine the spray volume of thin film material droplets based on the length and the width of the glass substrate. Next, spray a plurality of thin film material droplets in rows on the glass substrate through a plurality of nozzles of an inkjet head. The thin film material droplets are distributed in an approximate equilateral triangular pattern. The thin film material droplets in the shape of an approximate equilateral triangle can reduce instability when spreading on the glass substrate, achieving a target of optimized coatings. Finally, process an alignment material thin film which is formed after the thin film material droplets spread to form an alignment film. | 2012-03-15 |
20120064650 | MANUFACTURING METHOD OF THIN FILM TRANSISTOR AND LIQUID CRYSTAL DISPLAY DEVICE - Etching of a semiconductor layer including a part over a gate wiring and formation of a contact hole for connection between a pixel electrode and a drain electrode are performed by one-time photolithography step and one-time etching step; thus, the number of photolithography steps is reduced. The exposed part of the gate wiring is covered by an insulating layer, and this insulating layer also functions as a spacer for maintaining a space for a liquid crystal layer. By the reduction in the number of photolithography steps, a liquid crystal display device can be provided at lower cost and higher productivity. Using an oxide semiconductor for the semiconductor layer can realize a liquid crystal display device with low power consumption and high reliability. | 2012-03-15 |
20120064651 | METHOD FOR MANUFACTURING ORGANIC ELECTROLUMINESCENT DISPLAY APPARATUS - Provided is a method for manufacturing an organic electroluminescent display apparatus that includes a substrate and a plurality of pixels each including two or more types of sub-pixels, in which the pixels are arranged in a display area of the substrate, and, among the sub-pixels, one type of sub-pixels are specified sub-pixels provided at certain intervals. The specified sub-pixels are formed by selectively forming the (2n-1)th specified sub-pixels (wherein n represents an integer of 1 or more) numbered from a side end of the display area using a mask having openings at positions corresponding to the (2n-1)th specified sub-pixels numbered from the side end, and selectively forming the (2n)th specified sub-pixels numbered from the side end using a mask having openings at positions corresponding to the (2n)th specified sub-pixels numbered from the side end. | 2012-03-15 |
20120064652 | OPTOELECTRONIC DEVICES AND A METHOD FOR PRODUCING THE SAME - A light-emissive device comprising a light-emissive material provided between first and second electrodes such that charge carriers can move between the first and second electrodes and the light-emissive material, wherein the device includes a layer of a polymer blend provided between the first and second electrodes, phase separation of the polymers in the polymer blend having been induced in at least a portion of the polymer blend so as to control the propagation of light emitted by the light-emissive material in a predetermined direction. | 2012-03-15 |