| 11th week of 2013 patent applcation highlights part 48 |
| Patent application number | Title | Published |
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| 20130066062 | NUCLEIC ACID EXTRACTION METHOD, NUCLEIC ACID EXTRACTION REAGENT KIT, AND NUCLEIC ACID EXTRACTION REAGENT - A method is provided that is suitable for various test samples and that prepares nucleic acid templates directly usable for gene amplification reaction such as PCR method or RT-PCR method conveniently and promptly, preferably under a mild condition. A nucleic acid extraction method is provided comprising a process of contacting a nucleic acid extraction reagent with a test sample, wherein the nucleic acid extraction reagent comprises zwitterionic buffer solution. Preferably, the nucleic acid extraction reagent comprises a surfactant and a proteolytic enzyme. | 2013-03-14 |
| 20130066063 | BICYCLO[6.1.0]NON-4-YNE REGENTS FOR CHEMICAL MODIFICATION OF OLIGONUCLEOTIDES - The present invention provides for compounds of Formulae I and II: | 2013-03-14 |
| 20130066064 | NOVEL PROCESS - A single-phase LPS extraction composition comprising water, an alcohol and a further organic solvent, where the amount of water is between about 0.8 to 1.2% (v/v). | 2013-03-14 |
| 20130066065 | OXIDATION PROCESS FOR PREPARING 3-FORMYL-CEPHEM DERIVATIVES - The present invention relates to an improved process for oxidizing 3-hydroxy-methyl-cephem derivatives to the corresponding 3-formyl-cephem derivatives. In particular this oxidation process is for the preparation of 7-[2-(5-amino-[1,2,4]thia-diazol-3-yl)-2-hydroxyimino-acetylamino]-3-formyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid derivatives of formula (I) using a combination of a hypervalent iodine oxidizing agent of the type 10-I-3 such as bis(acetoxy)iodo-benzene (BAIB) and a catalyst such as 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO). These compounds of formula (I) are intermediates in the synthesis of ceftobiprole. | 2013-03-14 |
| 20130066066 | Method for Late Introduction of the (8R)-Hydroxyl Group Carbapenem Beta-Lactam Antibiotic Synthesis - The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in | 2013-03-14 |
| 20130066067 | Synthetic Process for the Manufacture of Ecteinascidin Compounds - This invention relates to compounds of formula II: wherein R | 2013-03-14 |
| 20130066068 | PHOTO-RESPONSIVE LIQUID CRYSTALLINE COMPOUND AND ITS APPLICATIONS - The purpose of the present invention is to provide novel liquid crystalline compounds that are capable of inducing phase transition by a light stimulus and are useful in the display, optoelectronics, and photonics field. The present invention relates to the liquid crystalline compounds represented by general formula (1): | 2013-03-14 |
| 20130066069 | PROCESSES FOR PREPARING SUBSTITUTED PYRIMIDINES - The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions. | 2013-03-14 |
| 20130066070 | PROCESS FOR PRODUCING ESTER COMPOUND - To provide an environmentally-friendly method for producing industrially an ester compound. | 2013-03-14 |
| 20130066071 | CARBANUCLEOSIDE SYNTHESIS AND NOVEL INTERMEDIATE COMPOUNDS USEFUL THEREIN - Anti-virally active carbanucleosides such as entecavir are prepared by a process which utilizes, throughout the synthesis, an aromatic protectant group for the hydroxyl and the alkyl hydroxy groups of the starting material, removed as the final step of a multi-step synthesis. Such protectant groups yield intermediates which are solid and therefore easily purified at various stages of the process, for an economical and relatively fast process for synthesizing the final product. | 2013-03-14 |
| 20130066072 | CRYSTALS OF SALTS OF PHENYLALANINE DERIVATIVES - Provided is a crystal of a salt of the compound represented by formula (I), which is excellent in its solubility in water. In particular, also provided is a crystal of hydrochloride, hydrobromate, sulfate, nitrate, p-toluenesulfonate or methanesulfonate of the compound represented by formula (I). | 2013-03-14 |
| 20130066073 | PROCESS FOR THE PREPARATION OF DIHYDROQUINAZOLINES - The present invention relates to a process for the preparation of dihydroquinazolines, which are used for the production of medicaments. | 2013-03-14 |
| 20130066074 | PROCESS FOR THE PREPARATION OF PROPENAL INTERMEDIATE AND DERIVATIVES THEREOF - The present invention provides an improved process for the preparation of (E)-N-(4-(4-fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-enyl)pyrimidin-2-yl)-N-methyl methanesulfon-amide, which is a useful intermediate for the preparation of (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl methylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxy hept-6-enoic acid, commonly known as Rosuvastatin. | 2013-03-14 |
| 20130066075 | PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR NON-ALCOHOLIC STEATOHEPATITIS - Provided is a compound useful in the prevention and treatment of non-alcoholic steatohepatitis. A prophylactic and/or therapeutic agent for non-alcoholic steatohepatitis which contains, as the active ingredient, 2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide, an acid-addition salt thereof, or a solvate of the same. | 2013-03-14 |
| 20130066076 | Process for the Synthesis of Biaryl Oxazolidinones - The present invention relates to processes for the preparation of biaryl oxazolidinones. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. | 2013-03-14 |
| 20130066077 | BINDING SYSTEMS - A method of adapting a synthetic substrate for immobilisation of a target molecule thereon. | 2013-03-14 |
| 20130066078 | METHODS OF NANOASSEMBLY OF A FRACTAL POLYMER AND MATERIALS FORMED THEREBY - The invention relates to the formation of synthesized fractal constructs and the methods of chemical self-assembly for the preparation of a non-dendritic, nano-scale, fractal constructs or molecules. More particularly, the invention relates to fractal constructs formed by molecular self-assembly, to create synthetic, nanometer-scale fractal shapes. In an embodiment, a nanoscale Sierpinski hexagonal gasket is formed. This non-dendritic, perfectly self-similar fractal macromolecule is comprised of bisterpyridine building blocks that are bound together by coordination to (36) Ru and (6) Fe ions to form a nearly planar array of increasingly larger hexagons around a hollow center. | 2013-03-14 |
| 20130066079 | FORMS OF RIFAXIMIN AND USES THEREOF - The present invention relates to Rifaximin polymorphic, salt, hydrate, and amorphous forms, to their use in medicinal preparations and to therapeutic methods using them. | 2013-03-14 |
| 20130066080 | Production of Alkaloids without the Isolation of Intermediates - The invention relates to processes for the production of alkaloids without the isolation of intermediates. | 2013-03-14 |
| 20130066081 | IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides Chalcone linked Imidazolone compounds of formula A as anti cancer agent against fifty three human cancer cell lines. | 2013-03-14 |
| 20130066082 | Metal-Enolate Precursors For Depositing Metal-Containing Films - Organometallic compounds suitable for use as vapor phase deposition precursors for metal-containing films are provided. Methods of depositing metal-containing films using certain organometallic precursors are also provided. Such metal-containing films are particularly useful in the manufacture of electronic devices. | 2013-03-14 |
| 20130066083 | PROCESSES AND INTERMEDIATES - The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof. | 2013-03-14 |
| 20130066084 | EQUOL-CONTAINING EXTRACT, METHOD FOR PRODUCTION THEREOF, METHOD FOR EXTRACTION OF EQUOL, AND EQUOL-CONTAINING FOOD - The present invention relates to an extract obtained by extracting useful components containing equol from an equol-containing fermented soybean hypocotyl, and to a method for producing the same. | 2013-03-14 |
| 20130066085 | EQUOL-CONTAINING EXTRACT, METHOD FOR PRODUCTION THEREOF, METHOD FOR EXTRACTION OF EQUOL, AND EQUOL-CONTAINING FOOD - The present invention relates to an extract obtained by extracting useful components containing equol from an equol-containing fermented soybean hypocotyl, and to a method for producing the same. | 2013-03-14 |
| 20130066086 | NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES - The present invention provides phosphonate conjugates and methods of preparing the phosphonate conjugates so as to allow, for example, improved methods and compounds for modifying the surface of a nanoparticle to increase in vivo circulation times and targeted delivery performance. | 2013-03-14 |
| 20130066087 | METHODS FOR PREPARING 17-ALKYNYL-7-HYDROXY STEROIDS AND RELATED COMPOUNDS-2 - The invention relates to processes for preparing 17-alkynyl-7-hydroxy-steroids, such as 17-Ethynyl-10R,13S-dimethyl 2,3,4,7,8R,9S,10,11,12,13,14S,15,16,17-hexadecahydro-1H-cyclopenta[a]phenanthrene-3R,7R,17S-triol (also referred to as 17α-ethynyl-androst-5-ene-3β,7β,17β-triol), that are essentially free of process impurities having binding activity at nuclear estrogen receptors. | 2013-03-14 |
| 20130066088 | METHODS FOR OBTAINING HIGH-YIELDING OIL PALM PLANTS - Methods are provided for obtaining a high-yielding oil palm plant, comprising determining the level of a protein in mesocarp tissue of a fruit of a parental oil palm plant, determining whether there is a difference between the level of the protein in the mesocarp tissue of the fruit of the parental oil palm plant and the level of the protein in mesocarp tissue of a fruit of a reference oil palm plant, and selecting progeny of the parental oil palm plant based on the difference to obtain the high-yielding oil palm plant. Also provided are methods for predicting oil yield of a test oil palm plant and kits for obtaining a high-yielding oil palm plant. | 2013-03-14 |
| 20130066089 | METHOD OF PRODUCING SATURATED ALKYL ESTERS/ACIDS - Disclosed herein is the production of saturated alkyl esters or acids from furan materials. The starting compounds contain furan, ketone, and ester or acid functional groups and may be biologically-derived. The method includes hydrogenating the starting compound to form a reduced mixture. The method further includes hydrodeoxygenation of the reduced mixture to yield a saturated alkyl ester or acid. The saturated alkyl ester or acid can be unbranched or branched. The ester and acid products have a wide variety of applications and may be further processed into surfactants, solvents, and lubricants suitable for use in consumer products. | 2013-03-14 |
| 20130066090 | BLOWN AND STRIPPED PLANT-BASED OILS - A method for producing a high viscosity, low volatiles blown stripped plant-based oil is provided. The method may include the steps of: (i) obtaining a plant-based oil; (ii) heating the oil to at least 90° C.; (iii) passing air through the heated oil to produce a blown oil having a viscosity of at least 50 cSt at 40° C.; (iv) stripping the blown oil from step (iii) to reduce an acid value of the blown oil to from 5 mg KOH/g to about 9 mg KOH/g; (v) adding a polyol to the stripped oil from (iv); and (vi) stripping the oil from step (v) to reduce the acid value of the oil to less than 5.0 mg KOH/g or less. | 2013-03-14 |
| 20130066091 | PROCESS FOR HYDROCHLORINATION OF MULTIHYDROXYLATED ALIPHATIC HYDROCARBONS - A process for producing a chlorohydrin, an ester of a chlorohydrin, or a mixture thereof including the steps of contacting, in a hydrochlorination reactor, a multihydroxylated aliphatic hydrocarbon, an ester of a multihydroxylated aliphatic hydrocarbon, or a mixture thereof with a source of a hydrogen chloride, in the presence of a hydrophobic or extractable carboxylic acid catalyst is provided. | 2013-03-14 |
| 20130066092 | USE OF GOLD COMPLEXES IN OPTOELECTRONIC DEVICES - The invention relates to gold(I) complexes having a planar-trigonal coordination geometry and multivalent ligands for use in an optoelectronic device, in particular in organic light-emitting diodes (OLEDs) and in light-emitting electrochemical cells (LEECs). | 2013-03-14 |
| 20130066093 | METAL (II) COORDINATION POLYMERS AND SYNTHESIZING METHOD THEREOF - The present invention relates to metal (II) coordination polymers and synthesizing method therefore, and particularly relates to metal (II) coordination polymers, in which divalent metal ions are Mg, Ca, Sr, Mn, or Zn and organic ligands are 4,4′-sulfonyldibenzoic acids (H | 2013-03-14 |
| 20130066094 | ADSORBENT FOR REMOVING METAL COMPOUNDS AND METHOD FOR SAME - Disclosed are effective and simple adsorbents and methods of using the adsorbents for removing metal impurities generated during storage, transportation and supply of organometallic compounds. The disclosed adsorbents and methods provide for the easy and effective removal of the metallic impurities or compounds generated from decomposition of the organometallic compound during its transportation, storage, and supply. Namely, the disclosed adsorbents and methods permit the stable supply of a high purity organometallic compound desired in the semiconductor and photovoltaic cell. | 2013-03-14 |
| 20130066095 | PREPARATION OF ORGANOXYSILYL OR SILOXY-CONTAINING ETHYLNORBORNENE COMPOUND - When an organoxysilyl or siloxy-containing ethylnorbornene compound is prepared by hydrosilylation of 5-vinyl-2-norbornene with a hydrogen organoxysilane or siloxy compound in the presence of a platinum catalyst, hydrosilylation is conducted in the co-presence of an ammonium salt. The organoxysilyl or siloxy-containing ethylnorbornene compound is effectively prepared at high reactivity and selectivity. | 2013-03-14 |
| 20130066096 | Method for Preparing a Diorganodihalosilane - A method of preparing a diorganodihalosilane comprising the separate and consecutive steps of (i) contacting a copper catalyst with a mixture comprising hydrogen gas and a silicon tetrahalide at a temperature of from 500 to 1400° C. to form a silicon-containing copper catalyst comprising at least 0.1% (w/w) of silicon, wherein the copper catalyst is selected from copper and a mixture comprising copper and at least one element selected from gold, magnesium, calcium, cesium, tin, and sulfur; and (ii) contacting the silicon-containing copper catalyst with an organohalide at a temperature of from 100 to 600° C. to form at least one diorganodihalosilane. | 2013-03-14 |
| 20130066097 | PROCESS FOR PREPARING AN ORTHO-SUBSTITUTED 5-HALOPHENOL AND A SYNTHESIS INTERMEDIATE THEREOF - A process for preparing a 5-halophenol, ortho-substituted by an electron-donating group, is described. Also described, is a process for preparing a sulphonic ester of an ortho-substituted phenol, which is the synthesis intermediate for the ortho-substituted 5-halophenol. The process for preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester can include reacting a phenol ortho-substituted by an electron-donating group with a sulphonylating agent in the presence of a Lewis acid. The process for preparing a 5-halophenol ortho-substituted by an electron-donating group can include a first step of preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester, as described above; a second step of halogenating the protected phenol intermediate obtained in the preceding step, in the position para to the electron-donating group; and a third step of deprotecting the sulphonic ester function to hydroxyl. | 2013-03-14 |
| 20130066098 | Remote Assembly of Targeted Nanoparticles using H-Phosphate ENE/-YNE Hydrophosphonylation Reactions - The present invention provides phosphonate compounds and methods of preparing the phosphonate compounds so as to allow, for example, increased capability to modify nanoparticles for targeted drug delivery applications. | 2013-03-14 |
| 20130066099 | PROCESS FOR PREPARING ALKANEDIOL AND DIALKYL CARBONATE - The invention relates to a process for the preparation of an alkanediol and a dialkyl carbonate comprising: (a) reacting an alkylene carbonate and an alkanol in the presence of a transesterification catalyst to obtain a reaction mixture comprising dialkyl carbonate, unconverted alkanol, alkanediol, unconverted alkylene carbonate and an alkoxy alkanol impurity; (b) subjecting the reaction mixture to distillation in a first distillation column to obtain a top stream comprising dialkyl carbonate, alkanol and alkoxy alkanol impurity and a bottom stream comprising alkanediol and alkylene carbonate; (c) subjecting the bottom stream from the first distillation column to distillation in a second distillation column to obtain a top stream comprising alkanediol and a bottom stream comprising alkylene carbonate; (d) subjecting the lop stream from the first distillation column to distillation in a third distillation column in the presence of a catalyst to effect reaction of the alkoxy alkanol impurity with the dialkyl carbonate into a carbonate ether impurity, to obtain a top stream comprising alkanol and a bottom stream comprising dialkyl carbonate and carbonate ether impurity; and (e) subjecting the bottom stream from the third distillation column to distillation in a fourth distillation column to obtain a top stream comprising dialkyl carbonate and a bottom stream comprising dialkyl carbonate and carbonate ether impurity, and (f) recycling the bottom stream from the fourth distillation column to the first distillation column. | 2013-03-14 |
| 20130066100 | PROCESS FOR PREPARING CATALYST USED IN PRODUCTION OF UNSATURATED ALDEHYDE AND/OR UNSATURATED CARBOXYLIC ACID BY DEHYDRATION REACTION OF GLYCERIN, AND CATALYST OBTAINED - A process for preparing a catalyst used in a production of acrolein and acrylic acid by dehydration reaction of glycerin, characterized by the steps of mixing a solution of heteropolyacid or constituents of heteropolyacid, a solution of at least one metal selected from elements belonging to Group 1 to Group 16 of the Periodic Table of Elements or its onium and a carrier to obtain a solid substance, and then of effecting at least one time of calcination before said solid substance is used in the dehydration reaction of glycerin. | 2013-03-14 |
| 20130066101 | PROCESS FOR PREPARING BIARYL SUBSTITUTED 4-AMINO BUTYRIC ACID OR DERIVATIVES THEREOF AND THEIR USE IN THE PRODUCTION OF NEP INHIBITORS - The invention relates to a process for producing a compound according to formula (i) | 2013-03-14 |
| 20130066102 | LACOSAMIDE INTERMEDIATE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF - A new compound is provided, which is used for preparing lacosamide. A novel method for preparing lacosamide is also provided. During the reaction, iodomethane and silver oxide that are cost expensive are not used, nor a Pd-c catalyst is used, so the production cost is low, the raw materials and accessory materials are cheap and easily available, and the process is simple, so that industrial production is easy to realize; and moreover, the yield is high, and good economic efficiency can be achieved. | 2013-03-14 |
| 20130066103 | High Vinyl Terminated Propylene Based Oligomers - This invention relates to a co-oligomer having an Mn of 300 to 30,000 g/mol comprising 10 to 90 mol % propylene and 10 to 90 mol % of ethylene, wherein the oligomer has at least X % allyl chain ends, where: 1) X=(−0.94(mole % ethylene incorporated)+100), when 10 to 60 mole % ethylene is present in the co-oligomer, and 2) X=45, when greater than 60 and less than 70 mole % ethylene is present in the co-oligomer, and 3) X=(1.83*(mole % ethylene incorporated)−83), when 70 to 90 mole % ethylene is present in the co-oligomer. This invention also relates to a homo-oligomer, comprising propylene, wherein the oligomer has: at least 93% allyl chain ends, an Mn of about 500 to about 20,000 g/mol, an isobutyl chain end to allylic vinyl group ratio of 0.8:1 to 1.2:1.0, and less than 100 ppm aluminum. This invention also relates to a process of making homo-oligomer, comprising propylene, wherein the productivity is greater than 4500 g/mmol Hf (or Zr)/hour. | 2013-03-14 |
| 20130066104 | METHOD AND PLANT FOR PURIFYING UNSATURATED COMPOUNDS - Process for purifying unsaturated compounds, and a plant for performing the process. Unsaturated compound obtained by the process. | 2013-03-14 |
| 20130066105 | MODIFIED CARBON MATERIAL AND PROCESS OF MAKING AND USING THE SAME - A method of making modified carbon materials for use in fabricating fuel cell components. The modified carbon may comprise pendant fluorocarbon groups bonded covalently bonded thereto. In one embodiment, a mixture is formed and comprises carbon material suitable for use in a fuel cell component, an organic solvent, a compound having the general formula I-R wherein R is a fluorocarbon, and a reductant. | 2013-03-14 |
| 20130066106 | DRYING AGENT - One embodiment of the present invention discloses a drying agent having the formula: [Mg | 2013-03-14 |
| 20130066107 | Production of Acetic Acid with High Conversion Rate - A process for producing acetic acid comprising the steps of reacting carbon monoxide and at least one of methanol and a methanol derivative in a first reactor under conditions effective to produce a crude acetic acid product; separating the crude acetic acid product into at least one derivative stream, at least one of the at least one derivative stream comprising residual carbon monoxide; and reacting at least a portion of the residual carbon monoxide with at least one of methanol and a methanol derivative over a metal catalyst in a second reactor to produce additional acetic acid. Preferably the second reactor is a homogeneous reactor and a reactor carbon monoxide partial pressure is less than 1.05 MPa. | 2013-03-14 |
| 20130066108 | CONTINUOUS METHOD FOR MANUFACTURING BETAINE AQUEOUS SOLUTION - The present invention relates to a method for continuously preparing a betaine aqueous solution, including the reaction of an amine with an ω-halocarboxylic acid, in the presence of water and a base. Said method is characterized in that it is carried out in a device consisting of at least two consecutive reactors (R | 2013-03-14 |
| 20130066109 | COMPOUNDS AND RELATED METHODS OF USE - Described herein are compounds of formula (I), related compositions, and their use, for example in the formation of α-amino acids or a precursor thereof such as an α-aminonitrile. | 2013-03-14 |
| 20130066110 | METHOD FOR MANUFACTURING FLUORINE-CONTAINING IMIDE COMPOUND - With this method for manufacturing fluorine-containing imide compounds, a method for manufacturing a fluorine-containing imide compound ((Rf | 2013-03-14 |
| 20130066111 | Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation - The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of:
| 2013-03-14 |
| 20130066112 | MULTI-AMINE FUNCTIONAL OLIGOMERS AND METHOD FOR PRODUCING THE SAME BY THE REDUCTION OF CORRESPONDING OXIMES - The invention relates to multi-amine functional oligomers and multi-oxime functional oligomers in addition to a method for producing the same by means of the co-polymerisation of carbonyl carriers such as olefins or dienes, reaction with hydroxylamine and a subsequent selective catalytic hydrogenation. | 2013-03-14 |
| 20130066113 | PROCESS FOR PREPARING ALKYLATED P-PHENYLENEDIAMINES - A process for preparing alkylated p-phenylenediamine having the steps of reacting aniline and nitrobenzene in presence of a complex base catalyst to obtain 4-aminodiphenylamine intermediates, hydrogenating the 4-aminodiphenylamine intermediates to 4-aminodiphenylamine in presence of a hydrogenation catalyst, and reductively alkylating the 4-aminodiphenylamine to alkylated p-phenylenediamine. | 2013-03-14 |
| 20130066114 | INSECTICIDE FOR AGRICULTURAL OR HORTICULTURAL USE AND METHOD OF USE THEREOF - Aniline derivatives represented by formula (8): | 2013-03-14 |
| 20130066115 | METHODS AND SYSTEMS FOR FORMING BORONIC ACIDS AND INTERMEDIATES THEREOF - Methods for forming boronic acids, and intermediates thereof, are disclosed. The method may include mixing a 1-chloro-2-substituted-3-fluorobenzene starting material with an alkyllithium in a first reactor to form a reaction mixture. The 1-chloro-2-substituted-3-fluorobenzene starting material may react with the alkyllithium to form a lithiated intermediate. The reaction mixture may be continuously transferred to a second reactor and a borate may be continuously introduced to form a boronate. The boronic acids may be formed by treating the boronate with aqueous potassium hydroxide followed by acidification. Such methods may provide continuous formation of the boronic acids and may reduce an amount of a reactive intermediate present during processing as well as cycle times. Systems for forming the boronic acids are also disclosed. | 2013-03-14 |
| 20130066116 | METHOD FOR THE DEPOLYMERIZATION OF LIGNOCELLULOSIC BIOMASS - The present invention relates to a method for the depolymerization of lignin or of derivatives thereof, including a step of heating the lignin or the derivatives thereof in the presence of a hydroxide of general formula M(OH)n or of a mixture of M(OH)n hydroxides, where M is a metal of the alkali or alkaline-earth family and n is equal to 1 or 2, and where the mass ratio between said hydroxide or mixture of hydroxides and the lignin or the derivatives thereof is comprised between around 0.5 and around 20. | 2013-03-14 |
| 20130066117 | PROCESS FOR ISOLATION AND PURIFICATION OF CAROTENOIDS - The present invention discloses a novel saponification process for the isolation and purification of highly pure carotenoids from different carotenoid rich oleoresin derived from plants and microorganisms without the use of toxic chemicals and hazardous solvents. The hydrolysis is carried out by treating the carotenoid rich oleoresin with a novel mixture of a Fatty alcohol, alkali and a fatty acid without the use of any other solvents. Further the invention explains a process of stabilising the carotenoids from getting degraded due to high temperature and exposure time during the saponification process. Further the invention discloses an economically viable process of isolating high pure carotenoids with higher yield. | 2013-03-14 |
| 20130066118 | METHOD OF MAKING ALCOHOLS - Methods and systems for the synthesis of alcohol are described herein. The methods and systems include a method of hydrating an olefin that may include emulsifying an olefin gas in a water stream in a high shear device under high shear conditions to produce a dispersion; and contacting the dispersion with a catalyst to hydrate the olefin gas and form an alcohol. | 2013-03-14 |
| 20130066119 | METHOD AND APPARATUS FOR THE SEPARATION OF A LIQUID FROM A GAS FEED STREAM IN A CATALYTIC REACTOR - Method and apparatus for separating a liquid reaction product from a gaseous stream in a catalytic reactor by means of a metallic sheet being indirectly cooled by a cooling surface and having a plurality of percolations in form of geometric-shaped protrusions on both sides of the sheet each with an open base, the open base is on the side of the sheet facing a catalyst bed are arranged upwards and on the side facing the cooling surface the open base faces downwards. | 2013-03-14 |
| 20130066120 | Renewable Diesel Refinery Strategy - A process is disclosed that permits the manufacture of renewable diesel while simultaneously manufacturing petroleum based jet fuel and/or diesel fuel. The process provides for the sulfiding of hydroprocessing catalyst used to hydroprocess sulfur deficient biomass derived feedstocks and permits the use of petroleum derived feedstock deactivated hydoprocessing catalyst in biomass derived feedstock service. | 2013-03-14 |
| 20130066121 | HYDROISOMERIZATION AND SELECTIVE HYDROGENATION OF FEEDSTOCK IN IONIC LIQUID-CATALYZED ALKYLATION - A process for producing alkylate comprising contacting a first hydrocarbon stream comprising at least one olefin having from 2 to 6 carbon atoms which contains 1,3-butadiene and 1-butene with a hydroisomerization catalyst in the presence of hydrogen under conditions favoring the simultaneous selective hydrogenation of 1,3-butadiene to butenes and the isomerization of 1-butene to 2-butene and contacting the resulting stream and a second hydrocarbon stream comprising at least one isoparaffin having from 3 to 6 carbon atoms with an acidic ionic liquid catalyst under alkylation conditions to produce an alkylate is disclosed. | 2013-03-14 |
| 20130066122 | DIESEL FUEL PRODUCTION DURING LUBRICANT BASE OIL HYDROPROCESSING - Conditions selected for lubricant base oil production can be used to also produce a high quality diesel product. The diesel product can have a cetane index or cetane number of at least 55, corresponding to a high value diesel fuel. The diesel product can also have good cold flow properties, such as a pour point of −40° C. or less and/or a cloud point of 25° C. or less. Additionally, the sulfur content of the diesel product can be low, such as less than 1 wppm. This can allow the diesel product to be blended with other potential diesel boiling range products that have a higher sulfur content while still meeting an overall diesel fuel specification. The aromatics content can also be low, allowing the premium diesel to comply with various regulatory requirements. | 2013-03-14 |
| 20130066123 | PROCESS FOR TRANSALKYLATING AROMATIC HYDROCARBONS - The present invention is a process for transalkylating aromatic hydrocarbon compounds, the process comprising introducing an aromatic hydrocarbon feed stream into a transalkylation zone to yield high-purity benzene as a byproduct while meeting transalkylation objectives. The feed stream contacts a catalyst in the transalkylation zone under conditions adjusted to control benzene purity as well as transalkylation performance. | 2013-03-14 |
| 20130066124 | PROCESS FOR PRODUCTION OF HIGH PURITY BETA-CAROTENE AND LYCOPENE CRYSTALS FROM FUNGAL BIOMASS - The present invention relates to a simple and economic method of extracting a crystalline Carotenoid compound, such as Beta-carotene, Lycopene, with a purity of at least 99%. The present invention further describes a process to prepare such a highly pure crystalline Carotenoid compound from microbial biomass, using an Anti-purity compound removal process followed by a mono-solvent extraction method. Further the process describes value addition of the co-products recovered during the extraction process thus resulting in a highly economical industrial method for the production of such high purity crystalline Carotenoids compound. | 2013-03-14 |
| 20130066125 | Extending the Life of an Aromatization Catalyst - A method of extending the life of an aromatization catalyst comprising identifying a rapid deactivation threshold (RDT) of the catalyst, and oxidizing the catalyst prior to reaching the RDT. A method of aromatizing a hydrocarbon comprising identifying a rapid deactivation threshold (RDT) for an aromatization catalyst, and operating an aromatization reactor comprising the catalyst to extend the Time on Stream of the reactor prior to reaching the RDT. A method of extending the life of an aromatization catalyst comprising predicting a rapid deactivation threshold (RDT) for an aromatization reactor by employing the catalyst in a reactor system under an accelerated fouling condition to identify a test rapid deactivation threshold (t-RDT), predicting the RDT for the aromatization reactor based upon the t-RDT, and oxidizing the catalyst prior to the predicted RDT to extend the Time on Stream of the aromatization catalyst. | 2013-03-14 |
| 20130066126 | PRE-CARBURIZED MOLYBDENUM-MODIFIED ZEOLITE CATALYST AND USE THEREOF FOR THE AROMATIZATION OF LOWER ALKANES - The present invention relates to a method for producing a zeolite catalyst useful for aromatization of a lower alkane, a zeolite catalyst useful for aromatization of a lower alkane obtainable by said method and a process for aromatization of a lower alkane using the zeolite catalyst of the present invention. | 2013-03-14 |
| 20130066127 | METHODS FOR PRODUCING CYCLOHEPTATRIENE - This invention relates to methods for producing cycloheptatriene from at least 7,7-dichloronorcarane and a liquid component comprising a C | 2013-03-14 |
| 20130066128 | NOVEL NICKEL-BASED CATALYTIC COMPOSITION AND METHOD OF OLIGOMERIZATION OF OLEFINS USING SAID COMPOSITION - The present invention describes a novel catalytic composition comprising at least one nickel complex, said complex being obtained from a mixture comprising at least one nickel precursor A with at least one imino-imidazole ligand B and a method of oligomerization of olefins using said catalytic composition. | 2013-03-14 |
| 20130066129 | CATALYST FOR PROPYLENE PRODUCTION, METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING PROPYLENE - Disclosed is a propylene production catalyst for producing propylene from one or more selected from a group consisting of methanol, dimethyl ether and olefins having from 4 to 8 carbon atoms. The catalyst comprises a binderless crystalline aluminosilicate shaped body having a silicon/aluminium atomic ratio of from 500 to 10000, in which the crystalline aluminosilicate contains an MFI-type crystal structure and/or an MEL-type crystal structure. The catalyst reduces the production amount of ethylene, paraffin components such as propane, and aromatic components, and increases the propylene yield and the propylene/propane ratio, and the catalyst life is long. | 2013-03-14 |
| 20130066130 | IONIC LIQUID CATALYZED ALKYLATION PROCESSES & SYSTEMS - Ionic liquid alkylation processes may comprise contacting at least one hydrocarbon stream with an ionic liquid catalyst in an ionic liquid alkylation zone under ionic liquid alkylation conditions, cooling at least one of a reactor effluent and a hydrocarbon phase of the reactor effluent, and recycling the cooled reactor effluent or cooled hydrocarbon phase to the ionic liquid alkylation zone. Ionic liquid alkylation systems for performing ionic liquid catalyzed alkylation processes are also disclosed. | 2013-03-14 |
| 20130066131 | Novel Catalyst To Increase Propylene Yields From A Fluid Catalytic Cracking Unit - A catalyst composition resulting in increased propylene yields during fluid catalytic cracking processes comprises (i) Y zeolite, (ii) ZSM-5 zeolite, and (iii) Beta zeolite. | 2013-03-14 |
| 20130066132 | CONVERSION OF HF ALKYLATION UNITS FOR IONIC LIQUID CATALYZED ALKYLATION PROCESSES - Methods for converting an H | 2013-03-14 |
| 20130066133 | CONVERSION OF HF ALKYLATION UNITS FOR IONIC LIQUID CATALYZED ALKYLATION PROCESSES - Methods for converting an HF alkylation unit to an ionic liquid alkylation system configured for performing ionic liquid catalyzed alkylation processes may comprise connecting at least one component configured for ionic liquid catalyzed alkylation to at least one component of the HF alkylation unit, wherein the at least one component of the HF alkylation unit is retained, modified or adapted for use in the ionic liquid alkylation system. An ionic liquid alkylation system derived from an existing or prior HF alkylation unit is also disclosed. | 2013-03-14 |
| 20130066134 | Multiplexed Radiation Therapy - A radiation system is provided comprising a single source of therapeutic radiation that is directed toward at least two treatment spaces in succession. Each treatment space houses a patient to be treated, each patient being secured generally by a separate supporting device adapted to support the patient in a generally sitting or standing or horizontal position. The x-ray source first delivers at least one beam to the first patient in the first space and then the x-ray source/patient relationship is adjusted so as to deliver an at least one beam to an at least second patient in a second space. | 2013-03-14 |
| 20130066135 | NEUTRON IRRADIATION THERAPY DEVICE - A device for irradiating cancer patients with neutrons, useful in Boron Neutron Capture Therapy, using at least one neutron emitter mounted and controlled so as to deliver a measured dose of neutrons directed at a treatment site or sites. | 2013-03-14 |
| 20130066136 | MAGNETIC BASED DEVICE FOR RETRIEVING A MISPLACED ARTICLE - A device for locating and retrieving a misplaced foreign body that has metallic characteristics includes a shaft connected to a handle and a retrieval tool that is coupled to the shaft and moves between a deployed position and collapsed position. The tool has a magnetic element that generates a magnetic field, wherein the magnetic field extends over a greater area in the deployed position and is of sufficient strength to attract the foreign body such that it is held in contact with the tool. The device can be part of an automated robotic system and can also include a metal detector to assist in locating the misplaced foreign body. | 2013-03-14 |
| 20130066137 | METHODS AND SYSTEMS FOR ESTABLISHING, ADJUSTING, AND/OR MODULATING PARAMETERS FOR NEURAL STIMULATION BASED ON FUNCTIONAL AND/OR STRUCTURAL MEASUREMENTS - Methods and systems for establishing, adjusting, and/or modulating parameters for neural stimulation based, at least in part, on functional and/or structural measurements are disclosed. A method in accordance with one embodiment includes measuring a volume of functionally active neural tissue within a patient's central nervous system both before and after affecting a target neural population of the patient with electromagnetic stimulation. The method further includes controlling at least one signal delivery parameter with which the electromagnetic stimulation is applied to the patient based, at least in part, on the measured difference in the volume of functionally active neural tissue. | 2013-03-14 |
| 20130066138 | Magnetic Field Treatment Techniques - The invention involves enhancing brain function by stimulating the brain using magnetic fields. Applications of the new methods include improving the condition of individuals with cognitive disorders, such as depression, and studying the effects of neural stimulation using induced electric fields. These techniques can avoid deleterious effects of psychotropic pharmaceutical treatments, and provide a relatively safe, comfortable, inexpensive means of direct cranial stimulation. | 2013-03-14 |
| 20130066139 | PUMP OR ROTARY CUTTER FOR OPERATION IN A FLUID - The invention relates to an apparatus for mechanical action upon a medium ( | 2013-03-14 |
| 20130066140 | HEART ASSIST DEVICE WITH EXPANDABLE IMPELLER PUMP - An impeller includes a hub and a blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed configuration in which the blade extends away from the hub. The impeller may be part of a pump for pumping fluids, such as blood, and may include a cannula having a proximal portion with a fixed diameter, and a distal portion with an expandable diameter. The impeller may reside in the expandable portion of the cannula. The cannula may have a compressed diameter which allows it to be inserted percutaneously into a patient. Once at a desired location, the expandable portion of the cannula may be expanded and the impeller expanded to the deployed configuration. A flexible drive shaft may extend through the cannula for rotationally driving the impeller within the patient. | 2013-03-14 |
| 20130066141 | IMPLANTABLE CARDIAC THERAPY DEVICE - An implantable cardiac therapy device having a heart assist pump, a stimulation unit, and a control unit. The heart assist pump is designed to be connected to a ventricle of a heart and an associated artery, and is designed to pump blood from a particular ventricle into an associated artery, thereby supporting the particular ventricle. The stimulation unit is designed to electrically stimulate a heart contraction, and the control unit is designed to control the heart assist pump and the stimulation unit in such a way that the stimulation unit induces synchronized motions of cardiac contraction while the heart assist pump operates in a ventricle-supporting manner. | 2013-03-14 |
| 20130066142 | IMPLANTABLE CARDIAC THERAPY DEVICE - A cardiac therapy device having a cardiac assist pump, a defibrillation unit, and a control unit, which is connected to the cardiac assist pump and the defibrillation unit to control them. The cardiac assist pump is implemented in case of use to pump blood from a ventricle into an associated artery and thus relieve the respective ventricle. The defibrillation unit is implemented for automatic defibrillation of a ventricular fibrillation and the control unit is implemented to activate the cardiac assist pump and the defibrillation unit in a coordinated manner in case of a ventricular fibrillation such that the cardiac assist pump first increases its performance to initially cause a pressure relief of at least one assisted ventricle in case of use and the defibrillation unit only subsequently delivers a defibrillation shock, when a ventricular pressure relief is provided. | 2013-03-14 |
| 20130066143 | MICROENVIRONMENT AND METHOD OF CONVEYING USER INSTRUCTIONS - A method and microenvironment includes accessing a dynamic image from a computer-readable medium and displaying the dynamic image on a display device communicatively connected to the microenvironment. The dynamic image includes a representation of an action performed by a clinician with respect to the microenvironment. | 2013-03-14 |
| 20130066144 | TISSUE ANCHOR WITH INSERTION DEVICE - In one embodiment, a medical device includes an elongate member and a tissue anchor. The elongate member defines a lumen. The elongate member has a retention member disposed within the lumen. The tissue anchor has a first arm portion, a second arm portion, and a base portion extending between the first arm portion and the second arm portion. The tissue anchor has a first configuration and a second configuration. The first arm portion is substantially linear when the tissue anchor is in its first configuration and the first arm portion is non-linear when the tissue anchor is in its second configuration. The tissue anchor is biased to its second configuration. The tissue anchor is configured to be disposed within the lumen defined by the elongate member such that the retention member engages the tissue anchor to help retain the tissue anchor in its first configuration. | 2013-03-14 |
| 20130066145 | MEDICAL DEVICE AND METHODS OF DELIVERING THE MEDICAL DEVICE - The present invention discloses a medical device and a method of placing the medical device within a patient's body. The medical device includes a support member, a first elongate member, a second elongate member and a coupling member. The first elongate member and the second elongate member extend from the support member. The coupling member includes a first portion and a second portion. The first portion of the coupling member is coupled to a distal end portion of the first elongate member and the second portion of the coupling member is coupled to a distal end portion of the second elongate member. | 2013-03-14 |
| 20130066146 | IMPLANTABLE MEDICAL DEVICE AND METHODS OF DELIVERING THE IMPLANTABLE MEDICAL DEVICE - A medical device and method of delivery of the medical device within a patient's body are disclosed by the present invention. The medical device includes a first elongate member and a second elongate member. A first portion and a second portion of the second elongate member are configured to form a defined non-planar shape such that the first portion is a first arm of the defined non-planar shape and the second portion is a second arm of the defined non-planar shape. | 2013-03-14 |
| 20130066147 | Apparatus and Method for Facilitating Male Orgasm - A male masturbation device and method for using same facilitates orgasm without the necessity of the subject achieving an erection. The novel device comprises a housing ( | 2013-03-14 |
| 20130066148 | METHOD OF AUGMENTING GLANS - Disclosed is a method of augmenting the glans that can safely and naturally expand the glans without causing problems such as an unnatural rough or shiny surface of the glans and the severe side effects of epidermal necrosis, which are caused by the conventional method of augmenting the glans. The method includes inserting an injector needle for injecting a filler into the central area of the lamina propria through the peripheral area of the ostium urethrae externum of the glans, slowly injecting the filler while checking with visual and tactual senses that the glans tissue where the filler is injected swells up and becomes tight and pressure resistance occurs and is maintained during injection of the filler, and slowly injecting the filler whereby the filler is uniformly spread by changing the depth and the direction of the inserted injector needle to expand half the glans area with a one-time injection. | 2013-03-14 |
| 20130066149 | ENDOSCOPIC HOOK BLADE AND USE THEREOF - An endoscopic surgical blade is disclosed. The blade is of a hook design, having an upper cutting surface located on the trailing edge of an arm and a lower cutting surface on the upper edge of the main body of the blade. The blade is part of an endoscopic knife assembly which also contains a knife tube and alignment ring. The endoscopic knife assembly is for use in endoscopic surgery by insertion of the assembly through a slotted cannula. The knife tube is hollow and allows the insertion of an endoscope for viewing of the surgical procedure. A method for a performing an operative procedure on a target tissue in a subject using an endoscopic knife assembly having a hook blade is also described. | 2013-03-14 |
| 20130066150 | ZOOM LENS MODULE AND ENDOSCOPE SYSTEM INCLUDING THE SAME - A zoom lens module and an endoscope system including the zoom lens module are disclosed. The zoom lens module includes: a first liquid lens; a second liquid which is disposed separated from the first liquid lens; and an aperture disposed between the first and second liquid lenses. A respective focal distance of each of the first liquid lens and the second liquid lens is adjustable based on a change of at least one of the respective curvature thereof and the respective thickness thereof. | 2013-03-14 |
| 20130066151 | Tracheal Intubation Device - A tracheal intubation device for placing an endotracheal tube in the trachea of a patient is disclosed. The tracheal intubation device includes a bar-shaped camera, a handle portion, a guiding portion, and a display device. The bar-shaped camera for capturing images is placed inside the endotracheal tube. The display device is electrically connected to the bar-shaped camera for displaying images captured by the bar-shaped camera. The guiding portion connected to the handle portion has a front end and a rear end, wherein the rear end is connected to the handle portion, and the bar-shaped camera and the endotracheal tube are movably situated in the guiding portion. | 2013-03-14 |
| 20130066152 | Tracheal Intubation Device - A tracheal intubation device includes a handle portion, a display unit, a bar-shaped camera, and a guiding portion. The display unit is electrically connected to the bar-shaped camera. The bar-shaped camera is used for capturing images and includes a camera rear end and a camera front end. The camera rear end is electrically connected to the display unit for displaying images captured by the bar-shaped camera. The camera front end has a bended portion. The guiding portion includes a front end and a rear end, wherein the front end is detachably connected to the handle portion. The guiding portion is used for accommodating the bar-shaped camera and the endotracheal tube to allow the bar-shaped camera and the endotracheal tube to move within the guiding portion. | 2013-03-14 |
| 20130066153 | ELECTRICAL DEVICE POWER MANAGEMENT - An electrical device includes a memory storing a value indicative the remaining available rated capacity of one or more batteries. The stored value is changed in use to reflect reducing capacity. The initial stored value is chosen so that there is a very high (e.g. >99.9%) confidence that the one or more batteries will provide at least the capacity indicated by the initial stored value. This reduces the chance of failure during emergency procedures. The one or more batteries may be integral to the electrical device. An override facility is provided. | 2013-03-14 |
| 20130066154 | TISSUE RETRACTOR APPARATUS AND METHODS - A delicate tissue retraction system having a hollow tubular retractor, a hollow tubular introducer that is removably installed within the retractor, and a navigation module that is removably installed within the introducer. The navigation module has a shaft with a proximal shaft end and a distal shaft end, and a navigation unit mounted to the proximal shaft end. When assembled, the distal shaft end is contained generally within the introducer and the navigation module outside the introducer. The navigation module indicates the location of one or more points on at least one of the retractor and the introducer to a navigation system. | 2013-03-14 |
| 20130066155 | LAPAROSCOPIC SURGICAL DEVICE - A laparoscopic surgical device comprising an anchor element comprising a pair of jaws defining a mouth within which at least a portion of an organ or tissue may be grasped is described. The jaws are biased towards one another so as to normally adopt a closed configuration. The anchor element is coupled to a support member, the support member being moveable about the anchor element. The device is dimensioned to be operably passed fully through a trocar into the abdominal cavity wherein it may be manipulated by a surgeon or other operator to grasp the desired target organ or tissue. | 2013-03-14 |
| 20130066156 | SURGICAL TOOL GUIDE AND PROTECTION CAP FOR SURGICAL TOOL GUIDE - The present invention relates to a surgical tool guide, which is easily installed and separated to reduce operating time, and furthermore surgical instruments are not separated from the abdominal walls or gas does not leak to stably perform the surgical operation. In addition, the present invention relates to a protection cap for a surgical instrument guide, which is interlocked together with surgical instruments to maintain a seal even though the surgical instruments for the operation are variously moved, thereby efficiently preventing the leakage of gas. Therefore, since it is unnecessary to inject gas again during the operation, the surgical operation can be smoothly performed. | 2013-03-14 |
| 20130066157 | SYSTEM FOR BODY ACCESS HAVING ADJUSTABLE DIMENSIONS - A device including a hollow pipe with a variable diameter is used for medical procedures. Means are provided for reducing the diameter either internally or externally so that the pipe can be inserted into a patient's body through an incision or an opening until the distal end of the pipe reaches a desired position. Thereafter, the diameter of the pipe is increased to allow various surgical devices to be introduced through the pipe. | 2013-03-14 |
| 20130066158 | Fabric Retraction Device and Method for Minimally Invasive Surgery - The present invention is directed to methods and instruments for performing tissue retraction in minimally invasive spinal surgery. Another specific application includes surgical methods performed through the percutaneously retracted tissue at any location in a patient's body. The tissue retraction is provided by an elongated sleeve formed from fabric materials, which may include the ability to stretch beyond their original length along at least one axis, for passage of instruments or implants. | 2013-03-14 |
| 20130066159 | METHOD FOR SECURING VERTEBRAE - A surgical access system for accessing a surgical target site within a spine includes a retractor and an elongated element. The refractor has a closed configuration defining a lumen with an internal circumference, and an open configuration in which the internal circumference, at least at the distal end of the retractor, is enlarged relative to said closed configuration. The open configuration creates and maintains an operative corridor to said target site. The elongated element is releasably coupled to an interior wall of the retractor and has an extension extending distal of the distal end of the retractor into the surgical target site. When coupled to the retractor, the elongated element covers a body structure at the target site without blocking access to the operative corridor. | 2013-03-14 |
| 20130066160 | CANNULA FOR RECEIVING SURGICAL INSTRUMENTS - A cannula ( | 2013-03-14 |
| 20130066161 | SURGICAL HAND ACCESS APPARATUS - A surgical access apparatus includes a liner base and an access housing for positioning outside the body. The liner base includes an inner member adapted for insertion through an opening within body tissue for positioning within the body; a sleeve member connected to the inner member and dimensioned to extend from the inner member through the opening within the body tissue, and a plurality of tensioning elements connected to the inner member and associated with the sleeve member to impart a tensioning effect on the sleeve member. The access housing includes a first element and a second element. The second element is operatively connected to the tensioning elements and adapted for rotational movement relative to the first member to cause the tensioning elements to displace the inner member toward the access housing and to cause the sleeve member to engage and retract tissue defining the opening within the body. | 2013-03-14 |
