| 11th week of 2013 patent applcation highlights part 39 |
| Patent application number | Title | Published |
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| 20130065162 | METHOD OF FABRICATING WAVE-SHAPED MASK AND EXPOSURE METHOD OF FABRICATING NANO-SCALED STRUCTURE USING THE WAVE-SHAPED MASK - A method of fabricating wave-shaped mask is disclosed. The method of fabricating wave-shaped mask comprises the steps of providing an elastomeric transparent substrate comprising an upper surface and a lower surface, applying a stable force to the elastomeric transparent substrate for deforming the elastomeric transparent substrate, forming a light-penetrable thin film layer on the upper surface of the elastomeric transparent substrate, and removing the force applying to the elastomeric transparent substrate, whereby the upper surface of the elastomeric transparent substrate and the light-penetrable thin film layer are in a periodic wave shape and the lower surface of the elastomeric transparent substrate is in a plate shape. | 2013-03-14 |
| 20130065163 | METHOD OF MANUFACTURING EUV MASK - Techniques for easily fabricating defect-free EUV masks with good yield are provided. A method of manufacturing an EUV mask according to the present invention includes the steps of: carrying out a defect inspection after depositing a multilayer film on a substrate; if a defect is found in the defect inspection, determining whether the defect is a recessed defect, a protruded defect, or defects in which the recessed defect and the protruded defect are mixed, and if the defects are the mixed defects of the recessed defect and the protruded defect, determining the relation in size between the defects; and depositing an additional multilayer film on the multilayer film while changing a film forming method in accordance with the results of the determination. | 2013-03-14 |
| 20130065164 | PELLICLE FOR LITHOGRAPHY AND A METHOD OF MAKING THEREOF - A pellicle is proposed wherein the mask-bonding agglutinant layer coated on one annular face of the pellicle frame is designed to have a cross-section which is trapezoidal (including the case of rectangle) so that the angle alpha (α) included between the side wall of the agglutinant layer and said annular face is 90 degrees or smaller. | 2013-03-14 |
| 20130065165 | MASK BLANK, TRANSFER MASK, METHOD OF MANUFACTURING A TRANSFER MASK, AND METHOD OF MANUFACTURING A SEMICONDUCTOR DEVICE - A mask blank is used for manufacturing a binary mask adapted to be applied with ArF excimer laser exposure light and has a light-shielding film for forming a transfer pattern on a transparent substrate. The light-shielding film has a laminated structure of a lower layer and an upper layer and has an optical density of 2.8 or more for the exposure light. The lower layer is made of a material containing tantalum and nitrogen and has a thickness of 33 nm or more. The upper layer is made of a material containing tantalum and oxygen and has a thickness of 3 nm or more. The phase difference between the exposure light transmitted through the light-shielding film and the exposure light transmitted in air for a distance equal to the thickness of the light-shielding film is 60 degrees or less. | 2013-03-14 |
| 20130065166 | PHASE SHIFT MASK BLANK AND PHASE SHIFT MASK - The present invention provides a photomask blank used for producing a photomask to which an ArF excimer laser light is applied, wherein: a light-shielding film is provided on a light transmissive substrate; the light-shielding film has a laminated structure in which a lower layer, an interlayer and an upper layer are laminated in this order from the side close to the light transmissive substrate; the thickness of the entire light-shielding film is 60 nm or less; the lower layer is made of a film containing a metal and has a first etching rate; the upper layer is made of a film containing a metal and has a third etching rate; the interlayer is made of a film containing the same metal as that contained in the lower layer or the upper layer and has a second etching rate that is lower than the first etching rate and the third etching rate; and the thickness of the interlayer is 30% or less of the thickness of the entire light-shielding film. | 2013-03-14 |
| 20130065167 | PHOTORESIST COMPOSITION FOR COLOR FILTER AND METHOD FOR FORMING COLOR FILTER - A photoresist composition for a color filter is provided which includes a) a coloring agent, b) a binder resin, c) a photopolymerization initiator, d) a photopolymerizable monomer, and e) a solvent, wherein a siloxane-based material is bonded to the binder resin. | 2013-03-14 |
| 20130065168 | COLOR FILTER FOR LOW TEMPERATURE APPLICATIONS - A color filter comprising a cured layer of a photosensitive resist composition comprising a highly reactive polyacrylate monomer and an alkali soluble binder having a side chain containing an ethylenically unsaturated bond in the side chain and a process for the preparation thereof are provided. The color filter is especially useful for low temperature applications such as electrophoretic displays, polymer dispersed liquid crystal displays, OLED devices and the like. | 2013-03-14 |
| 20130065169 | ELECTROPHOTOGRAPHIC PHOTORECEPTOR, METHOD OF PRODUCING ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE - An electrophotographic photoreceptor includes a conductive substrate; and a photosensitive layer on the conductive substrate, wherein a layer having an outermost surface of the photoreceptor contains a polymer that is formed by polymerizing a crosslinkable charge transport material having an aromatic group and a —CH | 2013-03-14 |
| 20130065170 | ELECTROSTATIC CHARGE IMAGE DEVELOPING TONER, ELECTROSTATIC CHARGE IMAGE DEVELOPER, TONER CARTRIDGE, PROCESS CARTRIDGE, IMAGE FORMING APPARATUS, AND IMAGE FORMING METHOD - An electrostatic charge image developing toner includes: toner particles; and an external additive. The external additive contains sol-gel silica having a volume average particle diameter of from about 70 nm to about 400 nm and an average circularity of from about 0.5 to about 0.9, and a dielectric loss factor of the toner is from about 5×10 | 2013-03-14 |
| 20130065171 | LATENT ELECTROSTATIC IMAGE DEVELOPING CARRIER, PROCESS CARTRIDGE AND IMAGE FORMING APPARATUS - A latent electrostatic image developing carrier including: core particles each having magnetism; and a coating layer covering each of the core particles, wherein the latent electrostatic image developing carrier has a shape factor SF-2 of 115 to 150 and has a bulk density of 1.8 g/cm | 2013-03-14 |
| 20130065172 | TONER, DEVELOPER, AND IMAGE FORMING APPARATUS - A toner including a colorant and a first binder resin is provided. The first binder resin has first and second glass transition points at a temperature Tg1 of −20 to 20° C. and a temperature Tg2 of 35 to 65° C., respectively, measured by a differential scanning calorimeter at a heating rate of 5° C./min. A ratio h1/h2 of a baseline displacement h1 observed in the first glass transition point to a baseline displacement h2 observed in the second glass transition point is less than 1.0. The first binder resin has a structure in which a first phase is dispersed in a second phase. The first and second phases consist of portions having larger and smaller phase difference values, respectively, than an intermediate value between maximum and minimum phase difference values in a binarized phase image obtained by an atomic force microscope with a tapping mode method. | 2013-03-14 |
| 20130065173 | ELECTROSTATIC CHARGE IMAGE DEVELOPING TONER, ELECTROSTATIC CHARGE IMAGE DEVELOPER, TONER CARTRIDGE, PROCESS CARTRIDGE, IMAGE FORMING APPARATUS, AND IMAGE FORMING METHOD - An electrostatic charge image developing toner includes: a polyester resin that has a glass transition temperature of about 45° C. or higher and in which a proportion of repeating units derived from fumaric acid in repeating units derived from acid components is 10 mol % or greater and a proportion of repeating units derived from alkenylsuccinic acid in the repeating units derived from acid components is 10 mol % or greater; and a photopolymerization initiator, wherein a content of the photopolymerization initiator is from about 0.5% by weight to about 10% by weight. | 2013-03-14 |
| 20130065174 | TONER - An object of the present invention is to provide a toner in which a charging amount and rise of the charging amount are hardly influenced by change in a temperature and humidity environment, and pigment dispersibility is high in order to provide an image output having high transparency, color mixing properties, and color nuance stability. The present invention is a toner comprising toner particles each comprising a metallic compound and a colorant, wherein the metallic compound is a compound having a structure bonded to a metal in a site derived from —COOM | 2013-03-14 |
| 20130065175 | CARRIER FOR DEVELOPING ELECTROSTATIC LATENT IMAGE AND DEVELOPER - A carrier for developing electrostatic latent image, including a core material; and a coated layer covering the core material, including a binder resin and a particulate material, wherein the core material is exposed on the surface of the carrier at an areal ratio of from 0.1 to 5.0% and has the largest exposed part having an areal ratio not greater than 0.03%, and wherein the coated layer comprises the particulate material in an amount of from 100 to 500 parts by weight per 100 parts by weight of the binder resin. | 2013-03-14 |
| 20130065176 | LIQUID DEVELOPER - A liquid developer includes at least toner particles and an insulating liquid. The toner particles include a resin and a color material dispersed in the resin. 90 mass % or more of the insulating liquid is aliphatic saturated hydrocarbon having a carbon number of 11 to 16, and 20 to 60 mass % of the insulating liquid is aliphatic saturated hydrocarbon having a carbon number of 11 to 12. | 2013-03-14 |
| 20130065177 | METHOD FOR MANUFACTURING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER - A method for manufacturing an electrophotographic photosensitive member using plasma CVD includes steps of placing a cylindrical base member in a reactor which can be evacuated, the reactor having an electrode therein, so as to be spaced apart from the electrode, introducing a raw material gas for deposited film formation into the reactor, and applying an alternating voltage of a rectangular wave having a frequency in the range of 3 kHz to 300 kHz between the electrode and the cylindrical base member so that a potential at one of the electrode and the cylindrical base member with respect to a potential at the other becomes alternately positive and negative, to decompose the raw material gas, and forming a deposited film on the cylindrical base member. The magnitude of the potential difference between the electrode and the cylindrical base member is selectively controlled. | 2013-03-14 |
| 20130065178 | COMPOSITIONS AND PROCESSES FOR IMMERSION LITHOGRAPHY - New photoresist compositions are provided that are useful for immersion lithography. Preferred photoresist compositions of the invention comprises two or more distinct materials that can be substantially non-mixable with a resin component of the resist. Particularly preferred photoresists of the invention can exhibit reduced leaching of resist materials into an immersion fluid contacting the resist layer during immersion lithography processing. | 2013-03-14 |
| 20130065179 | POSITIVE RESIST COMPOSITION AND PATTERNING PROCESS - There is disclosed a positive resist composition comprising (A) a specific resin (B) a photo acid generator, (C) a basic compound, and (D) a solvent. There can be a positive resist composition having, in a photolithography using a high energy beam such as an ArF excimer laser beam as a light source, an excellent resolution, especially excellent depth of focus (DOF) characteristics with an excellent pattern profile, and in addition, in formation of a contact hole pattern, giving a pattern having excellent circularity and high rectangularity; and a patterning process using this positive resist composition. | 2013-03-14 |
| 20130065180 | RESIST COMPOSITION AND METHOD OF FORMING RESIST PATTERN - A resist composition comprising: a base component (A) which exhibits changed solubility in a developing solution under action of acid; an acid-generator component (B) which generates acid upon exposure; and a compound (D1) including of a cation moiety which contains a quaternary nitrogen atom, and an anion moiety represented by formula (d1-an1) or (d1-an2) shown below. In the formulas, X represents a cyclic aliphatic hydrocarbon group of 3 to 30 carbon atoms which may have a substituent; and Y | 2013-03-14 |
| 20130065181 | LITHOGRAPHIC PRINTING PLATE SUPPORT, METHOD OF MANUFACTURING THE SAME, AND PRESENSITIZED PLATE - A lithographic printing plate support in which surface unevenness due to surface treatment has been suppressed and a presensitized plate of excellent sensitivity are produced from an aluminum alloy plate containing iron, silicon, titanium and boron by specifying the state in which TiB | 2013-03-14 |
| 20130065182 | Fluorine-Containing Sulfonate, Fluorine-Containing Sulfonate Resin, Resist Composition and Pattern Formation Method - According to the present invention, there is provided a fluorine-containing sulfonate resin having a repeating unit of the following general formula (3). | 2013-03-14 |
| 20130065183 | PATTERNING PROCESS AND RESIST COMPOSITION - A resist composition is provided comprising a polymer comprising recurring units having a protected hydroxyl group, a photoacid generator, an organic solvent, and a hydroxyl-free polymeric additive comprising fluorinated recurring units. A negative pattern is formed by coating the resist composition, prebaking to form a resist film, exposing, baking, and developing the exposed film in an organic solvent-based developer to selectively dissolve the unexposed region of resist film. | 2013-03-14 |
| 20130065184 | CHARGED PARTICLE BEAM DRAWING METHOD AND CHARGED PARTICLE BEAM DRAWING APPARATUS - A charged particle beam drawing method according to an embodiment is a method including forming a first measurement pattern in a first measurement pattern area; in succession with processing of forming the first measurement pattern, forming a second measurement pattern in a second measurement pattern area located farthest from the first measurement pattern area in the same column as the first measurement pattern area; and in moving a charged particle beam from the second measurement pattern area to a third measurement pattern area located adjacent to the first measurement pattern area in the same column as the first and second measurement patterns to form a third measurement pattern, moving the charged particle beam to the third measurement pattern area while taking tiny shots approximately equivalent to a data resolution at the adjacent measurement pattern areas to be drawn in the same column one after another from the second measurement pattern. | 2013-03-14 |
| 20130065185 | Scanning Lithography using point source imaging arrays - A new and useful concept for imaging a substrate is provided, that includes a source of illumination comprising a plurality of point light sources, and imaging the substrate by projecting each point light source through a near field projection schema (e.g an array of near field lens elements) to create a predetermined illumination pattern at the substrate. | 2013-03-14 |
| 20130065186 | RADIATION-SENSITIVE RESIN COMPOSITION, METHOD FOR FORMING RESIST PATTERN, ORGANIC ACID AND ACID GENERATING AGENT - A radiation-sensitive resin composition includes an acid generating agent to generate an organic acid by irradiation with a radioactive ray. The organic acid has a cyclic hydrocarbon group and an organic group including a bond that is cleavable by an acid or a base to produce a polar group. The organic acid is preferably represented by a following formula (I). Z represents an organic acid group. R | 2013-03-14 |
| 20130065187 | METAL POWDER IGNITION APPARATUS, METAL POWDER IGNITION METHOD, COMPACT METAL POWDER COMBUSTION APPARATUS AND METAL POWDER COMBUSTION METHOD USING WATER PLASMA - A metal powder ignition apparatus using water plasma is provided. The metal powder ignition apparatus includes an ignition apparatus for igniting and combusting metal powder by injecting the water plasma into a mixture of the metal powder and steam functioning as an oxidizer for burning the metal powder. | 2013-03-14 |
| 20130065188 | BURNER AND PILOT PROTECTOR FOR HORIZONTAL FLAMMABILITY TEST CHAMBER - A burner shield ( | 2013-03-14 |
| 20130065189 | THERMAL TREATMENT APPARATUS, TEMPERATURE CONTROL SYSTEM, THERMAL TREATMENT METHOD, TEMPERATURE CONTROL METHOD, AND NON-TRANSITORY COMPUTER READABLE MEDIUM EMBODIED WITH PROGRAM FOR EXECUTING THE THERMAL TREATMENT METHOD OR THE TEMPERATURE CONTROL METHOD - A thermal treatment apparatus includes a processing container, a substrate holding unit for holding a plurality of substrates at predetermined intervals in a direction inside the processing container, a heating unit for heating the processing container, a supply unit for supplying gas, a plurality of supply ports provided respectively at different locations in the direction, and a cooling unit for cooling the processing container by supplying the gas into the processing container by the supply unit via each of the supply ports, wherein the supply unit is provided in such a way that the supply unit independently controls flow rates of the gases supplied via each of the supply ports. | 2013-03-14 |
| 20130065190 | FURNACE FOR MELTING INORGANIC SALTS - Furnace for melting inorganic salts, comprising a container ( | 2013-03-14 |
| 20130065191 | Palatal T-Bar - A palatal t-bar for preventing movement of selected teeth during corrective movement of other teeth through the use of an orthodontic appliance such as orthodontic braces. The t-bar comprises an elongate stem having an anchorage end arranged for affixation to the palatal bone of a patient by means of a temporary bone anchorage device, e.g., a miniscrew implant, and a free end extending in an anterior direction from the anchorage end. The stem is shaped to conform to the palatal surface of the patient. A cross-bar extends laterally from the free end of the stem and is arranged to engage one or more selected maxillary anterior teeth to retain the teeth non-mobile and non-rotational during corrective movement of other teeth utilizing an orthodontic appliance such as orthodontic braces. | 2013-03-14 |
| 20130065192 | Procedure and device for enabling a dental element to be applied to a dental arch - A process of applying at least one dental element to a patient's arch employs a device comprising a support tray shaped to fit to at least a portion of a patient's dental arch. A formed, liquid-soluble material (such as a thin starch layer formed from a starch sheet) is supported by the support tray and holds at least one dental element in a location for allowing an exposed surface of the at least one dental element to be applied to a patient's dental arch. Afterwards, the support tray is removed from the liquid-soluble material and the liquid-soluble is removed by dissolving it in a liquid, such as water. | 2013-03-14 |
| 20130065193 | Method for producing an orthodontic arch or retaining arch, device for performing said method, resulting orthodontic arch or retaining arch, and orthodontic appliance comprising same - The invention relates to a method for producing a bent orthodontic arch or a bent retaining arch for orthodontic treatment, comprising the bending of portions of a metal wire. The invention is characterised in that it comprises the use of an apparatus of the type intended for the production of springs, comprising bending tools and means allowing the continuous movement of the wire to be bent. The invention also relates to the device used to perform the aforementioned method, to the resulting orthodontic arch or retaining arch and to an orthodontic appliance comprising same. | 2013-03-14 |
| 20130065194 | ORTHODONTIC ADHESIVES - An orthodontic adhesive includes a curable resin monomer component; a quaternary curing initiator system; and filler. Another orthodontic adhesive having a W/C ratio (working time to curing time ratio) of at least 10, 12, 14 or 20, includes a curable resin monomer component; a curing initiator system; and filler. The adhesives are suitable as light-curing and may include a colorant. Suitable colorants include reversible, thermochromic dyes. The adhesive may also include a resin toughening component. | 2013-03-14 |
| 20130065195 | METHOD FOR MANUFACTURING A TEMPLATE FOR PROVIDING DENTAL IMPLANTS IN A JAW AND SCAN PROSTHESIS FOR APPLYING THIS METHOD - The invention concerns a method for manufacturing a template with at least one opening to drill through so as to create an appropriate bore hole in the bone of an at least partially toothless lower or upper jaw so as to fix an implant in said bone. | 2013-03-14 |
| 20130065196 | SYRINGE AND METHOD FOR DOSED DISPENSING OF MATERIALS - A syringe for dosed dispensing of material, in particular of free-flowing and/or pasty dental material, includes a sleeve for accommodating material and a piston inserted into the sleeve defining an inner sleeve chamber and which has a piston member, a frictional engagement element which abuts an inner wall of the sleeve, and an elastic element coupling the frictional engagement element and the piston member, wherein the elastic element can be tensioned, on insertion of the piston and/or of the piston member into the sleeve, by means of a relative lag of the frictional engagement element in relation to the piston member, wherein by relaxing the elastic element it is possible for the piston member to be expelled at least partially from the sleeve while the frictional engagement element remains motionless, to increase the volume of the inner sleeve chamber. | 2013-03-14 |
| 20130065197 | Driver and method - A driver assembly for driving a dental implant into an implantation site comprises a driver assembly having an abutment assembly, and a driver assembly. The lower portion of the driver assembly accommodates the upper portion of the abutment assembly in a rotation-preventing manner so as to prevent relative rotation between the driver assembly and the abutment assembly. In addition, the driver assembly includes a frangible section which permits the upper portion thereof to be separated from the lower portion and discarded while the lower portion remains mounted upon the abutment assembly. | 2013-03-14 |
| 20130065198 | JAW IMPLANT - A jaw implant includes an implant body comprising a top end, a base end, an axial line, an acute-angled long side, an obtuse-angled short side, a body core. An oval opening disposed at the top end comprises an opening edge lying in an opening plane inclined with an angle of inclination of 75° to 45° with respect to the axial line so that the implant body has an axial length on the acute-angled long side longer than on the obtuse-angled short side. An external thread structure comprises a lead comprising a lower side facing the base end, an upper side facing the top end, and a wedge angle disposed between the upper side and the lower side. A bisecting line of the wedge angle and the axial line of the implant body form a tilt angle which is smaller on the acute-angled long side than on the obtuse-angled short side. | 2013-03-14 |
| 20130065199 | DYNAMIC DENTAL CROWN - An artificial tooth system, including a denture-engaging body portion, a first recess formed in the denture-engaging body portion, and a pivot base positioned within the first recess and operationally connected to the denture-engaging body portion. A generally spherical ball connector extends from the pivot base. A pivot platform is pivotably connected to the generally spherical ball portion and a resilient ring is positioned around the generally spherical ball connector and situated between the pivot base and the pivot platform. A membrane is sealingly connected around the pivot base and the pivot platform. The tooth also includes a crown portion with a second recess formed in the crown portion, wherein the pivot platform is positioned within the second recess. | 2013-03-14 |
| 20130065200 | MULTICOLOR DENTAL BLANKS AND RELATED METHODS - A dental blank has at least an inner zone (or layer) of a first color and an outer zone (or layer) of a second color, wherein the inner and outer zones are concentric. The inner zone can be surrounded in its entirety by the outer zone such that only the outer zone is visible on all surfaces of the blank. Alternatively, the inner zone and the outer zone can extend to a same single surface of the blank, such that only the outer zone covers all remaining surfaces. The blank may also have an intermediate zone between the inner and outer zones. A method of fabrication includes solid free form processes, such as robocasting, laser sintering and 3D printing that allow for placement of multiple colors. A dental restoration made from the blank can have a variety of shades depending on a ratio of milled outer layers to internal layers. | 2013-03-14 |
| 20130065201 | Art instruction systems and methods using a border guide - Improved systems and methods using a border guide and/or border guide easel that enables art instruction in a relatively low cost and simple to use manner suitable for group or individual instruction of a relatively sophisticated nature. A scaled border guide preferably labeled with numbers and letters provides a virtual coordinate or reference system that enables artists to locate multiple random points on the surface to be painted. A physical grid or stencil or the like are not used on the artist's surface. The scaled border lines are used to define a virtual grid on the artist's working surface that may be used to indicate reference, points, positions, sizes and shapes for drawing or painting. Art instruction methods allow the teaching of drawing and painting in a more classical and relatively sophisticated style as compared to paint-by-numbers or grid art. | 2013-03-14 |
| 20130065202 | Method for designing test to assess skills for computer programming - This invention provides a method to design assessment tests for computer programming skill. Presently there are several tests like Microsoft and Java Certification. However, all the tests are not well designed and cannot provide accurate measure of genuine programming skills of testees. A good test for programming skill must have testee do the actual programming during the test. This invention is aimed at allowing testee to do the actual programming in tests while results can be graded by machine automatically. This is achieved by having questions in tests specially designed so that testee can only answer multiple-choice questions correctly if he makes the computer programs running correctly. The embodiment of this invention makes it implemented in various fields of Microsoft .Net and C# programming language and obviously applied to other languages. | 2013-03-14 |
| 20130065203 | MULTILAYER 3D FLOATING IMAGES IN A SINGLE SUBSTRATE - A multilayer sheeting with a 3D floating image. The sheeting includes a layer of microlenses and a multilayer material disposed adjacent the microlenses. The multilayer material includes multiple adjacent layers having X-Y planar positions and a Z-direction orthogonal to the X-Y planar positions. Individual images, which contrast with the material, are formed in the multilayer material and include connected elements at interfaces between the multiple layers and conjunction elements between connected elements. The connected elements are registered in the Z-direction at the X-Y planar positions in the interfaces between the layers. The individual images collectively form a composite 3D image that appears to the unaided eye to be three-dimensional and floating above or below the sheeting, or both. | 2013-03-14 |
| 20130065204 | AUGMENTATIVE AND ALTERNATIVE COMMUNICATION LANGUAGE SYSTEM - A method and device for providing a language system. The method includes displaying a home screen including a first plurality of user selectable communication keys, wherein each communication key represents a first word. In response to receiving a first indication of a user selection of a first key, it is determined whether the first key is linked to a secondary screen. If the first key is not linked to a secondary screen, an audible signal representing the first word is output. Otherwise, a secondary screen is displayed including a second plurality of communication keys that are related to the first word and a communication key that represents the first word. The device includes appropriate hardware for performing the method. In both the method and device, the language system is configured to output an audible output of a user selected word after no more than two user selections. | 2013-03-14 |
| 20130065205 | APPARATUS AND METHOD FOR GENERATING VOCAL ORGAN ANIMATION - The present disclosure relates to an apparatus and method for generating a vocal organ animation very similar to a pronunciation pattern of a native speaker in order to support foreign language pronunciation education. The present disclosure checks an adjacent phonetic value in phonetic value constitution information, extracts a detail phonetic value based on the adjacent phonetic value, extracting pronunciation pattern information corresponding to the detail phonetic value and pronunciation pattern information corresponding to a transition section allocated between detail phonetic values, and performs interpolation to the extracted pronunciation pattern information, thereby generating a vocal organ animation. | 2013-03-14 |
| 20130065206 | COMPUTER PROGRAM METHODS FOR EMULATING A MACHINE AND PRESENTING TRAINING SCENARIOS TO A USER - Computer program methods for emulating a process of a machine and training a user are disclosed. According to one embodiment, a computer program method for use with a computer device includes a computer usable medium having computer readable program code for training a user by emulating a process of a machine having actuators and mechanical elements. The computer readable program code includes computer readable code instructions configured to display a graphical user interface having input fields corresponding to the actuators and the mechanical elements. Also included are computer readable code instructions for displaying a training scenario to the user on the graphics display device. Computer readable code instructions are provided for emulating a mechanical operation of the machine using the parameters inputted into the input fields, generating output response data based on the emulation, and for displaying a feedback message to the user. | 2013-03-14 |
| 20130065207 | COMPUTER PROGRAM PRODUCTS AND MACHINES FOR EMULATING A MACHINE AND PRESENTING TRAINING SCENARIOS TO A USER - Computer program products and machines for emulating a process of a machine and training a user are disclosed. A computer program product for use with a computer device includes a computer usable medium having computer readable program code for training a user by emulating a process of a machine having actuators and mechanical elements. The computer readable program code includes computer readable code instructions configured to display a graphical user interface having input fields corresponding to the actuators and the mechanical elements. Also included are computer readable code instructions for displaying a training scenario to the user on the graphics display device. Computer readable code instructions are provided for emulating a mechanical operation of the machine using the parameters inputted into the input fields, generating output response data based on the emulation, and for displaying a feedback message to the user. | 2013-03-14 |
| 20130065208 | METHODS AND APPARATUS FOR EVALUATING A CANDIDATE'S PSYCHOLOGICAL FIT FOR A ROLE - In some embodiments, a non-transitory processor-readable medium stores code representing instructions to cause a processor to receive a first psychological profile identifying one or more psychological facets associated with a candidate for a role and a set of second psychological profiles identifying one or more psychological facets associated with the role. Each second psychological profile is associated with an assessment of the role by an evaluator from a set of evaluators. The code represents instructions to cause the processor to receive a set of post-interview assessments, each of which is from an interviewer from a set of interviewers and includes a degree of confidence that the candidate possesses the one or more psychological facets associated with the candidate. The code further represents instructions to cause the processor to compute an indicator associated with the first psychological profile, the set of second psychological profiles and the set of post-interview assessments. | 2013-03-14 |
| 20130065209 | NOSE BLOW TRAINING APPARATUS - A training apparatus for training a child how to blow his or her nose includes a tapered chute having proximal and distal ends. The tapered chute defines an internal passageway connecting the proximal and distal ends. The proximal end includes a proximal opening that is sufficiently wide to fit over a child's nose. The distal end includes a distal opening that is smaller than the proximal opening. The internal passageway includes a narrow portion, adjoining the distal opening, and sized to snugly accommodate a projectile lodged therein. When air is exhaled into the proximal opening, the exhaled air passes through the internal passageway and builds pressure behind the projectile such that the projectile is forcefully ejectable from the distal opening. | 2013-03-14 |
| 20130065210 | ADULT ASSISTED INFANT WALKING HARNESS - An infant walking harness is described. Embodiments may consist of a padded fabric harness that wraps around the upper chest and under an infant's crotch to provide all around support, while leaving the sides of the infant's lower torso uncovered. The top part of the harness or upper body section is designed like a vest with fastening means on the back. In one embodiment, the fastening means are hook and loop material patches allowing for adjustments based on the infant's chest circumference so as to provide a snug fit, important for the infant's balancing. Two vest loops ensure that there is no excessive movement in the upper chest and shoulder area of an infant. The bottom part of the harness or lower body section is designed to be adjusted up or down via hook and loop material patches to accommodate an infant's height. | 2013-03-14 |
| 20130065211 | Ultrasound Simulation Training System - The invention relates to a simulator training system for simulation training in ultrasound examination or ultrasound-guided procedures. The training system comprises a movable simulator input device to be operated by the user, and means for displaying an ultrasound scan view image which is an image or facsimile image of an ultrasound scan. The scan view image is variable and related to the position and/or orientation of the simulator input device. The system further includes means for displaying a second image, the second image being an anatomical graphical representation of a slice through of the body structure associated with the ultrasound scan view, the slice through displaying the scan beam plane of the simulator input device. The ultrasound scan view image and the second image are linked to vary in a coordinated manner as the position and/or orientation of the simulator input device changes. | 2013-03-14 |
| 20130065212 | Interactive online laboratory - A wireless sensor probe is used for performing experiments in an interactive laboratory. The probe may include a plurality of sensors for collecting experimental data during an experiment and a transmitter for wirelessly transmitting the collected data to a receiver module. The receiver module is adapted for transferring the data to a computer where a software component may process the data for presentation of the resultant processed data on a display substantially in real-time. | 2013-03-14 |
| 20130065213 | SYSTEM AND METHOD FOR ADAPTING AUDIO CONTENT FOR KARAOKE PRESENTATIONS - A system adapted to process non-karaoke-mode audio content for karaoke presentations is provided. An audio filter module filters a vocal portion from the non-karaoke-mode audio content to obtain filtered audio content. An audio rendering module renders the filtered audio content to generate an audio signal for output of the filtered audio content at an audio output device. A lyric acquiring module acquires lyric information associated with the non-karaoke-mode audio content. A lyric rendering module renders the lyric information to generate a display signal for display of the lyric information such that the lyric information is adapted to be displayed synchronously with the output of the filtered audio content. | 2013-03-14 |
| 20130065214 | Educational Assessment Support Systems And Methods Associated Methods - A system and method assess educational development of a child. Indication of accomplishment by the child of a plurality of tests is entered into the system. A report is generated to indicate educational areas of concern and strength for the child. | 2013-03-14 |
| 20130065215 | Education Method - An education system for educating one or more students wherein the student is presented with a setting and multiple responses. In the application of the system, one or more students provide a verbal response in accord with one of the multiple responses. The student's response is then incorporated into a dialog which is returned to the student. | 2013-03-14 |
| 20130065216 | Real-Time Interactive Collaboration Board - A real-time interactive collaboration system is provided, the system including at least: a collaboration board electronically connected between and amongst an instructor and one or more students, wherein the instructor and students are able to interact in real-time with previously uploaded objects that are part of a learning activity; means for the instructor and students to simultaneously share a predetermined view of the collaboration board; and means for the instructor and students to simultaneously share a portion of a predetermined view of the collaboration board at the discretion of the instructor. Methods of use for the foregoing system are also provided. | 2013-03-14 |
| 20130065217 | ORGAN PROTECTION SOLUTION AND METHOD OF USE - An organ protectant solution which is intravenously administerable includes a high concentration of cell impermeant molecules which have a charge and/or molecular weight which permit passage across a capillary endothelium and into an interstitial space in said subject but which are too large and/or charged to cross a cell plasma membrane such that said one or more cell impermeant molecules preferentially load into an extracellular fluid compartment can be used to to allow for improved organ harvesting from DCD and brain death donors for transplantation purposes and also can be used extend the “Golden Hour” for traumatic and hemorrhagic shock patients thereby allowing more time for those patients to reach a point of care facility to receive medical treatment. | 2013-03-14 |
| 20130065218 | MEDICAL FLUID, A METHOD OF TREATMENT AND USE OF THE FLUID - A medical fluid for a harvested organ, tissue or parts thereof, for evaluation and/or preservation. The fluid includes cocaine or a stimulating analogue thereof; nor-adrenalin; and/or adrenaline. In addition, the fluid includes an oncotic agent, such as dextran; hormones, such as thyroxin; triiodotyronine; cortisone, insulin; and electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium. In addition, the medical fluid further includes albumin in a concentration not exceeding 5.0%, and an oxygen carrier, such as erythrocytes. Further components may be dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin. The cocaine; adrenalin; and noradrenaline are present in concentrations of each about 0.010 μM to 0.100 μM, for example in a ratio of 1:1:1. | 2013-03-14 |
| 20130065219 | Nutrient Monitoring and Feedback Control for Increased Bioproduct Production - The present invention pertains to methods of increasing the efficiency of producing a bioproduct. In some embodiments, the method increases the quantity of a bioproduct produced, or decreases bioproduct production time, in a bioreactor cell culture producing the bioproduct, the method comprising, (a) intermittently or continuously analyzing the concentration of one or more nutrients in the bioreactor cell culture; and (b) adding to the bioreactor cell culture additional nutrient media when the concentration of the one or more nutrients is lower than a target value. | 2013-03-14 |
| 20130065220 | METHOD OF RAPIDLY DETECTING MICROORGANISMS USING NANOPARTICLES - The present invention relates to a method of rapidly detecting microorganisms using nanoparticles, and more particularly to a method and device of rapidly detecting microorganisms by adding, to the microorganisms to be detected, nanoparticles having immobilized thereon an antibody that binds specifically to the microorganisms to be detected, subjecting the mixture to an immune reaction to form a reaction solution, passing the reaction solution through a microorganism-concentrating film to concentrate the microorganisms, capturing microorganisms, which was immune-reacted with the antibody-immobilized nanoparticles, by a microorganism-capturing filtration membrane, and determining the presence and concentration of the microorganisms. | 2013-03-14 |
| 20130065221 | HMGB1 AND ANTI-HMGB1 ANTIBODIES FOR THE PROGNOSTIC OF NEUROLOGICAL DISORDERS - The invention relates to in vitro method for quantitating the antibodies specific for High mobility group box I (HMGB1) contained in a sample, in particular a serum sample or a cerebrospinal fluid sample obtained from a patient, and the use of this method in the prognostic and/or diagnosis of neurological disorders. These methods are in particular applicable to the monitoring of the human immunodeficiency virus (HIV) infection of a subject who is known to be infected with HIV and in the prognostic and/or diagnostic of the state of progression of Acquired immune deficiency syndrome (AIDS) or the state of progression toward AIDS, in particular the state of progression or the state of progression toward neurological disorders associated with AIDS. Finally, the invention is also about method to determine the immune deficiency or level of immune activation of a patient, in particular a HIV-infected patient. | 2013-03-14 |
| 20130065222 | COMPOSITIONS, METHODS AND REACTION MIXTURES FOR THE DETECTION OF MURINE LEUKEMIA VIRUS-RELATED VIRUS - The present invention relates to the detection of infectious agents, more specifically to the detection of murine leukemia viruses and other highly related viruses, including but not limited to ecotropic murine leukemia viruses, xenotropic murine leukemia viruses, and polytropic murine leukemia viruses. Compositions, methods, reaction mixtures and kits are described for the detection of MLV by using in vitro nucleic acid amplification techniques. | 2013-03-14 |
| 20130065223 | Universally Applicable Lysis Buffer and Processing Methods for the Lysis of Bodily Samples - The present invention provides a universally applicable lysis buffer comprising a chaotropic 5 agent, a reducing agent, and a proteolytic enzyme suitable for processing a wide variety o different sample types, such as different types of bodily samples relevant for the diagnosis o a respiratory disease. Furthermore, the present invention provides the use of a chaotropic agent, a reducing agent, and a proteolytic enzyme for the lysis of a broad spectrum of bodily samples. Moreover, the present invention provides a method for processing bodily samples which is universally applicable to the lysis of a variety of different types of bodily samples. Furthermore, the present invention provides methods for analyzing a bodily sample or for detecting the presence of a pathogen in a bodily sample, preferably, for diagnosing a respiratory disease, such as pneumonia or tuberculosis. Preferably, these methods are universally applicable to a variety of sample types, are applicable as one-tube-processes, are 15 suitable for performance in a high-throughput setting, and are automatable. | 2013-03-14 |
| 20130065224 | PERSONAL GLUCOSE METERS FOR DETECTION AND QUANTIFICATION OF A BROAD RANGE OF ANALYTES - A general methodology for the development of highly sensitive and selective sensors that can achieve portable, low-cost and quantitative detection of a broad range of targets using only a personal glucose meter (PGM) is disclosed. The method uses recognition molecules that are specific for a target agent, enzymes that can convert an enzyme substrate into glucose, and PGM. Also provided are sensors, which can include a solid support to which is attached a recognition molecule that permits detection of a target agent, wherein the recognition molecule specifically binds to the target agent in the presence of the target agent but not significantly to other agents as well as an enzyme that can catalyze the conversion of a substance into glucose, wherein the enzyme is attached directly or indirectly to the recognition molecule, and wherein in the presence of the target agent the enzyme can convert the substance into glucose. The disclosed sensors can be part of a lateral flow device. Methods of using such sensors for detecting target agents are also provided. | 2013-03-14 |
| 20130065225 | Reversible Di-Nucleotide Terminator Sequencing - The present teachings provide methods, compositions, and kits for synthesizing and sequencing nucleic acids. In some embodiments, reversible di-nucleotide compounds are employed along with cleaving reactions that remove a label and a blocking moiety. Improved sequencing efficiency is achieved by the rapid polymerase-mediated incorporation of reversible di-nucleotide compounds. In some embodiments, the di-nucleotides do not contain conventional nucleotide triphosphates, but rather employ amino acid phosphoramidate nucleotides (AAPNs). | 2013-03-14 |
| 20130065226 | METHOD OF DETERMINING DOSE AND ADMINISTRATION OF STATIN - The object of the present invention is to provide a method of determining the dose and/or administration of statins to a patient suffering from a cardiovascular disease. | 2013-03-14 |
| 20130065227 | METHODS OF INCREASING MACROPINOCYTOSIS IN CANCER CELLS - This disclosure describes methods of stimulating macropinocytosis in cancer cells. | 2013-03-14 |
| 20130065228 | GENOME-SCALE ANALYSIS OF ABERRANT DNA METHYLATION IN COLORECTAL CANCER - Particular aspects provide methods and compositions (e.g., gene marker panels) having substantial utility for at least one of diagnosis, identification and classification of colorectal cancer (CRC) (e.g., tumors) relating to distinctive DNA methylation-based subgroups of CRC including CpG island methylator phenotype (CIMP) groups (e.g., CIMP-H and CIMP-L) and non-CIMP groups. Exemplary marker panels include: B3GAT2, FOXL2, KCNK13, RAB31 and SLIT1 (CIMP marker panel); and FAM78A, FSTL1, KCNC1, MYOCD, and SLC6A4 (CIMP-H marker panel). Further aspects relate to genetic mutations, and other epigenetic markers relating to said CRC subgroups that can be used in combination with the gene marker panels for at least one of diagnosis, identification and classification of colorectal cancer (CRC) (e.g., tumors) relating to distinctive CIMP and non-CIMP groups. | 2013-03-14 |
| 20130065229 | BIOMARKERS FOR SYSTEMIC LUPUS ERYTHEMATOSUS - The present invention provides methods and reagents for diagnosing system lupus erythematosus and for monitoring system lupus erythematosus disease activity in a subject. | 2013-03-14 |
| 20130065230 | SOYBEAN EVENT pDAB9582.814.19.1 DETECTION METHOD - Soybean Event pDAB9582.814.19.1 comprises genes encoding Cry1F, Cry1Ac (synpro), and PAT, affording insect resistance and herbicide tolerance to soybean crops containing the event, and enabling methods for crop protection and protection of stored products. The invention provides PCR event detection methods. | 2013-03-14 |
| 20130065231 | Primer and Probe for Use In Detection of Mycobacterium Kansasii and Method for Detection of Mycobacterium Kansasii Using The Same - The present invention discloses an oligonucleotide which comprises a part or the entire sequence of the nucleotide sequence depicted in SEQ ID NOS: 1-4, or a part or the entire sequence of a nucleotide sequence complementary to SEQ ID NOS: 1-4, wherein the oligonucleotide is capable of hybridizing with the nucleotide sequence of | 2013-03-14 |
| 20130065232 | ASSAYS AND KITS FOR SEROTYPING PSEUDOMONAS AERUGINOSA AND OLIGONUCLEOTIDE SEQUENCES USEFUL IN SUCH METHODS AND KITS - The present invention relates to assays, kits and oligonucleotides for the detection of | 2013-03-14 |
| 20130065233 | DETECTION OF DNA METHYLATION - In a first aspect, the invention concerns a method for detecting or quantifying DNA methylation at a locus. In one embodiment, a methylation-sensitive endonuclease is formulated together with a polymerase enzyme in an appropriate reaction mixture such that amplification of DNA occurs in a methylation specific manor. Quantitative DNA amplification at selected loci can be used to determine the level of methylation. Kits and reagents for performing such methods are also provided. | 2013-03-14 |
| 20130065234 | METHOD FOR DIAGNOSING BONE AND JOINT DISEASE BASED ON SINGLE NUCLEOTIDE POLYMORPHISM IN CHROMOSOME 10Q24 - Provided is a method for diagnosing a bone and joint is disease such as scoliosis. A single nucleotide polymorphism present in region 24 on the long arm of chromosome 10 (region 10q24) is analyzed and the risk of onset of a bone and joint disease and/or the presence or absence of onset of the same are diagnosed on the basis of a result of the analysis. | 2013-03-14 |
| 20130065235 | BINDING AND FUNCTIONAL ASSAYS THAT USE THE T1R3 RECEPTOR TO SCREEN FOR TASTE MODULATORY COMPOUNDS - Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed. | 2013-03-14 |
| 20130065236 | METHOD FOR REAL-TIME NUCLEIC ACID AMPLIFICATION BY DROPLET MANIPULATION - The present invention provides a real-time nucleic acid amplification method capable of quickly and accurately detecting fluorescence obtained by a nucleic acid amplification method performed in a droplet in a perfect closed system. A real-time nucleic acid amplification reaction method for performing a nucleic acid amplification reaction in a droplet present in a container, wherein the droplet is composed of a nucleic acid amplification reaction liquid including a nucleic acid to be amplified and magnetic particles; the container holds a droplet encapsulating medium immiscible with the nucleic acid amplification reaction liquid forming the droplet, and has a transport surface having a temperature gradient; and at least the droplet encapsulating medium out of the droplet and the droplet encapsulating medium includes a fluorochrome at start of the nucleic acid amplification reaction, the method comprising transporting the droplet together with the magnetic particles by generating a magnetic field by means for applying a magnetic field to start and maintain a nucleic acid amplification reaction so that the droplet is placed on the transport surface at a temperature point at which the nucleic acid synthesis reaction is started and maintained, thereby controlling a temperature of the reaction liquid. | 2013-03-14 |
| 20130065237 | NOVEL MIXTURES FOR ASSAYING NUCLEIC ACID, NOVEL METHOD OF ASSAYING NUCLEIC ACID WITH THE USE OF THE SAME AND NUCLEIC ACID PROBE TO BE USED THEREFOR - [Problems] To provide a novel mixture for assaying a target nucleic acid, characterized by enabling a nucleic acid assay while: 1) requiring no step of diluting the target nucleic acid; 2) requiring no procedure of changing a probe concentration depending on a concentration of the target nucleic acid. | 2013-03-14 |
| 20130065238 | SYNGAP1 DYSFUNCTIONS AND USES THEREOF IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS FOR MENTAL RETARDATION - The invention identifies Syngap1 dysfunctions as causative of mental retardation. Described are methods of detecting mental retardation and methods of detecting non-syndromic mental retardation (NSMR) in a human subject. Particular methods comprise sequencing a human subject's genomic DNA for comparison with a control sequence from an unaffected individual. Also described are probes, kits, antibodies and isolated mutated Syngap1 proteins. | 2013-03-14 |
| 20130065239 | DIAGNOSTIC METHOD FOR DETECTING ACUTE KIDNEY INJURY USING HEAT SHOCK PROTEIN 72 AS A SENSITIVE BIOMARKER - The invention relates to a reliable, easy-to-implement non-invasive diagnostic method for detecting early acute kidney injury by measuring the concentration of a biomarker in urine samples, said biomarker being selected from heat shock proteins of the 70 KDa family. More specifically, the invention relates to the identification of heat shock protein 72, whereby said biomarker is identified by means of ELISA and Western blot or by means of the level of RNAm using real-time RT-PCR. The invention helps to solve the current problem that exists in medicine whereby it is not possible to detect acute renal failure in the early stages or the severity of the renal damage in order to treat the patient in a timely manner with an effective therapy. | 2013-03-14 |
| 20130065240 | CULTURE MEDIUM, METHOD FOR CULTURING SALMONELLA AND E. COLI AND METHOD FOR DETECTING SALMONELLA AND E. COLI - In embodiments there are disclosed culture media, compositions for supplementing culture media, and methods for culturing biological samples. In embodiments the methods are methods for detecting bacteria and in embodiments the bacteria include | 2013-03-14 |
| 20130065241 | Methods And Compositions Related To Continuous Flow Thermal Gradient PCR - Disclosed are compositions and a method for amplification and detection of nucleic acid sequences based on continuous flow thermal gradient PCR. | 2013-03-14 |
| 20130065242 | METHODS FOR DIAGNOSING, PROGNOSING AND TREATING MUSCULAR DYSTROPHY - Disclosed herein are methods for diagnosing, prognosing and treating muscular dystrophy. The disclosed methods can be used to diagnosis, prognosis or treat a subject with merosin-deficient congenital muscular dystrophy Type 1A (MDC1A), limb-girdle muscular dystrophy (LGMD), facioscapulohumeral (FHMD), Beckers muscular dystrophy (BMD) or Duchenne muscular dystrophy (DMD). Also disclosed are methods of determining the effectiveness of an agent for the treatment of muscular dystrophy. In an example, a method of diagnosing or prognosing a subject with muscular dystrophy includes detecting expression of Galectin-1 or Galectin-3 in a sample obtained from the subject at risk of having or having one or more signs or symptoms associated with muscular dystrophy, thereby diagnosing or prognosing the subject with muscular dystrophy. Also provided are methods of enhancing muscle regeneration, repair, or maintenance in a subject by administering galectin, such as Galectin-1 and/or Galectin-3 to a subject in need thereof. | 2013-03-14 |
| 20130065243 | METHOD FOR PRODUCING INDUCED PLURIPOTENT STEM CELLS - A major object of the present invention is to provide a method for producing induced pluripotent stem cells with low tumorigenesis potential and high induction efficiency. | 2013-03-14 |
| 20130065244 | METHOD FOR PRODUCING cAMP USING CHIMERIC OLFACTORY RECEPTOR - A method for producing cAMP using a chimeric olfactory receptor. The method includes a step of preparing a reaction system comprising a first layer, a lipid bilayer membrane, and a second layer, and a step of supplying a chemical substance which stimulates the chimeric olfactory receptor to the first layer so as to produce the cAMP from ATP. The lipid bilayer membrane includes the chimeric olfactory receptor and adenylate cyclase. The chimeric olfactory receptor penetrates the lipid bilayer membrane. The second layer contains ATP and a G protein. The G protein is placed in the vicinity of one end of the chimeric olfactory receptor. The chimeric olfactory receptor is derived from a mouse olfactory receptor and the N-terminal of the chimeric olfactory receptor is modified with an amino acid sequence. | 2013-03-14 |
| 20130065245 | Device - Provided is an assay device and kit for detecting the presence or amount of an analyte of interest. | 2013-03-14 |
| 20130065246 | METHOD FOR DIAGNOSING MELANOCYTIC PROLIFERATIONS - The invention provides a method for diagnosing a melanocytic proliferation in a subject comprising staining a sample of lesional melanocytes with an antibody against soluble adenylyl cyclase (sAC) and interpreting the sAC staining pattern, which is associated with a diagnosis of a melanocytic proliferation. The sAC staining pattern, which is complex, is discriminatory and distinctive according to the nature of the melanocytic proliferation. The sAC staining pattern comprises one or more of dot-like Golgi staining, broad granular Golgi staining, diffuse cytoplasmic staining, nucleolar staining, incomplete granular nuclear staining, and pan-nuclear staining. The method of the invention is particularly useful in confirming or disaffirming a diagnosis reached through conventional histologic examination of a sample. Additionally, the invention provides a kit for use in interpreting melanocytic proliferations. | 2013-03-14 |
| 20130065247 | METHODS OF DIAGNOSING LATENT AND ACTIVE MALIGNANCIES - Disclosed are procedures and methods for diagnosing latent and active cancers in a subject. The described methods include the use of sandwich ELISA assays containing antibodies specific for certain epitopes on the A-protein. This enables the assay to discriminate between the monomelic and homopolymeric forms of A-protein. | 2013-03-14 |
| 20130065248 | REAGENTS AND METHODS FOR SIRTUIN CAPTURE - The invention provides a method of preparing a sirtuin complex. The invention also provides a method of detecting a sirtuin in a sample comprising use of the aforesaid sirtuin complex. | 2013-03-14 |
| 20130065249 | SIGNAL AMPLIFICATION FOR IMMUNOASSAYS BY USE OF AVIDIN-BIOTIN LINKAGES - In sandwich-type immunoassays that capture a protein analyte between a capture antibody, typically bound to a solid phase, and a detection antibody that is coupled to a reporter group, the number of reporter groups associated with each molecule of analyte is increased by a variety of methods that utilize avidin-biotin-type binding in conjunction with such features as immunological binding to the reporter group on the detection antibody or multiple biotin-avidin-type binding sites. | 2013-03-14 |
| 20130065250 | Kit and Method for Detecting Porous Dental Hydroxyapatite - The present invention relates to a kit and a probe for detecting porous dental hydroxyapatite, comprising a protein capable of binding porous dental hydroxyapatite or a detector thereof. The invention also relates to a method for detecting a condition involving porous dental hydroxyapatite comprising detecting in or on a tooth or a sample of the tooth of a subject a protein bound to porous dental hydroxyapatite. The invention also relates to methods for detecting a hypomineralisation developmental dental defect or detecting intact and/or broken MIH enamel, and to a kit and method for removing a protein bound to porous dental hydroxyapatite. | 2013-03-14 |
| 20130065251 | METHOD AND SYSTEM FOR DETERMINATION OF MOLECULAR INTERACTION PARAMETERS - A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface. An analytical system for carrying out the method, a computer program, a computer program product and a computer system for performing the method are also disclosed. | 2013-03-14 |
| 20130065252 | COMPOSITIONS AND METHODS FOR DETECTING AUTOANTIBODIES - The invention provides compositions and methods for detecting thyroid hormone blocking immunoglobulin (TBI). The invention's methods are sensitive and specific for TBI, and may be used for the dual detection of both TBI and TSI. The invention's compositions and methods are useful for the diagnosis of diseases that are associated with the presence of TBI and/or TSI, for monitoring the progress of disease and/or treatment regimens, therapeutics, vaccines, etc., and for assisting clinicians in making treatment decisions. | 2013-03-14 |
| 20130065253 | DETECTION SYSTEM AND USES THEREFOR - A system for the detection of molecular associations, the system comprising: i) a first agent, comprising a first interacting group coupled to a first reporter component; ii) a second agent, comprising a second interacting group coupled to a second reporter component; iii) a third agent, comprising a third interacting group; iv) a modulator; and v) a detector; wherein proximity of the first and second reporter components generates a signal capable of detection by the detector; and wherein the modulator modulates the association of the second interacting group with the third interacting group; such that monitoring the signal generated by proximity of the first and second reporter components by the detector constitutes monitoring the association of the first and third agents. | 2013-03-14 |
| 20130065254 | NOVEL EPIGENETIC MECHANISMS RELATED TO DNA DAMAGE AND AGING - This invention pertains to markers of cellular senescence. In particular methylation of histone H1 (or isoforms thereof) at residue 172 and/or at residue 180 is a marker of cellular senescence. Antibodies specific to histone H1 (or isoforms thereof) methylated at residue 172 and/or at residue 180 are provided. | 2013-03-14 |
| 20130065255 | Biomarker to Measure Drug Efficacy in Enteropathic Disease - The diagnosis of a patient with an enteropathic disease or the response of a patient with an enteropathic disease to therapy, particularly a candidate therapy in a clinical trial setting, is assessed by detecting the ability of the patient to metabolize an orally administered CYP3A substrate. The CYP3A metabolism may be monitored in a variety of ways. Conveniently, the appearance of a metabolite of the CYP3A substrate is detected in a patient sample over a period of time following oral administration, e.g. in urine, plasma, serum breath, saliva, etc. The CYP3A substrate is optionally labeled, e.g. with an isotopic, fluorescent, etc. label. | 2013-03-14 |
| 20130065256 | ASSAY SYSTEM - An assay apparatus comprising: i) an assay cartridge ( | 2013-03-14 |
| 20130065257 | ENZYME-LOGIC BIOSENSING - Techniques, apparatus and systems are disclosed for implementing enzyme-logic based diagnosis that uses patterns of multiple markers and biochemical processing of the signal information for reliably identifying cardiac abnormalities and providing a final digital binary answer. In one aspect, a biochemical logic sensing system includes a network of enzyme-biocatalyzed logic gates adapted to receive biomarker input signals and perform an enzyme-biocatalyzed reaction resembling a Boolean logic operation using the received biomarker input signals to generate an output signal of the enzyme-biocatalyzed reaction. A signal processing unit is connected to the network of enzyme-biocatalyzed logic gates. The signal processing unit processes the generated output signal of the enzyme-biocatalyzed reaction and generates a digital binary output having a value of zero or one. The generated digital binary output indicates a type of an injury. | 2013-03-14 |
| 20130065258 | COLORECTAL CANCER MARKER GALECTIN, METHOD FOR ANALYZING GALECTIN CONCENTRATION IN BLOOD SAMPLE, AND KIT FOR DETECTING COLORECTAL CANCER MARKER GALECTIN - The present invention provides a tumor screening marker that can be actually used in clinical practice to detect colorectal cancer, and a tumor progression marker that can complement CEA or CA19-9. Galectin-1 used as a tumor screening marker or a tumor progression marker for colorectal cancer. Galectin-3 used as a tumor screening marker. Galectin-4 used as a tumor progression marker, a tumor screening marker, or a prognostic prediction marker for colorectal cancer. A method of analyzing the galectin concentration in a collected blood sample using the galectin. A colorectal cancer marker detection kit comprising a detection antibody selected from the group consisting of a fluorescently labeled galectin-1 antibody, a fluorescently labeled galectin-3 antibody, and a fluorescently labeled galectin-4 antibody. | 2013-03-14 |
| 20130065259 | METHODS FOR DETECTION OF BOTULINUM NEUROTOXIN - Provided herein is a large immuno-sorbent surface area assay (ALISSA) for the rapid and sensitive detection of botulinum neurotoxins (BoNTs) and anthrax toxin. This assay is designed to capture a low number of toxin molecules and to measure their intrinsic protease activity via conversion of a fluorogenic or luminescent substrate. Also provided herein are novel peptides that can be specifically cleaved by BoNT and novel peptides that are resistant to cleavage by BoNT. The combination of these cleavable and control peptides can be used for implementation of an exemplary ALISSA used to specifically detect BoNT enzymatic activity. Furthermore, the ALISSA as described herein may also be used in a column based format for use in a high-throughput system for testing large quantities of samples. | 2013-03-14 |
| 20130065260 | Compositions, Methods and Uses for Simultaneous Assay of Thrombin and Plasmin Generation - Embodiments of the present invention report compositions and methods of analyzing thrombin and plasmin generation in a sample from a subject. In certain embodiments, the methods may comprise introducing at least one activator of coagulation and at least one activator of fibrinolysis to a sample and analyzing the sample for kinetic parameters related to thrombin and plasmin generation. In other embodiments, assays disclosed herein concern assessing net hemostatic balance of a subject for diagnostic and/or therapeutic applications. | 2013-03-14 |
| 20130065261 | MODIFIED GLUCOSE DEHYDROGENASE GENE - The purpose of the present invention is to provide an FAD-conjugated glucose dehydrogenase that is hard to be inhibited by the inhibitors such as 1,10-phenanthroline. | 2013-03-14 |
