11th week of 2014 patent applcation highlights part 50 |
Patent application number | Title | Published |
20140073735 | AQUEOUS RESIN COMPOSITION COMPRISING A POLYESTER-POLYURETHANE RESIN AND A DENDRITIC POLYOL - An aqueous resin composition comprises a polyester-polyurethane resin and a dendritic polyol. The polyester-polyurethane resin is obtained by reacting, in a one-stage process or multi-stage process, a reaction mixture comprising a polyester polyol with a number-average molecular weight M | 2014-03-13 |
20140073736 | CURABLE COMPOSITION COMPRISING BIS-BENZOXAZINE, METHOD OF CURING, AND THE CURED COMPOSITION SO FORMED - The present invention deals with a novel curable composition comprising bis-benzoxazine and an amine-functionalized triazine, especially a di-isoimide, and the use thereof in the preparation of encapsulated printed wiring boards, especially flexible printed wiring boards. The curable composition hereof beneficially effects crosslinking of bis-benzoxazine at a lower temperature than has heretofore been provided in the art. | 2014-03-13 |
20140073737 | TRIAZINE CONTAINING FLUOROPOLYETHER ELASTOMERS HAVING LOW GLASS TRANSITION TEMPERATURE - There is provided a curable composition comprising: a) fluoropolyethers having a molecular weight of from about 400 g/mole up to about 20,000 g/mole and containing moieties selected from (—(CF | 2014-03-13 |
20140073738 | Hydrophilic Polymeric Particles and Methods for Making and Using Same - A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle. | 2014-03-13 |
20140073739 | THERMOPLASTIC ELASTOMER COMPOSITION AND ARTICLE MADE THEREFROM - The present invention relates to a thermoplastic elastomer composition, including an elastomer and a thermoplastic component having polyamide, polyethylene terephthalate and a compatibilizer. This present invention also relates to a thermoplastic elastomer article in which a hard thermoplastic matrix is made of a thermoplastic component that includes polyamide, polyethylene terephthalate and a compatibilizer, and soft elastomeric domains distributed within the hard thermoplastic matrix and made of an elastomer. | 2014-03-13 |
20140073740 | THERMOPLASTIC ELASTOMER COMPOSITION AND ARTICLE MADE THEREFROM - The present invention relates to a thermoplastic elastomer composition, including an elastomer and a thermoplastic component having polyamide, polyethylene terephthalate and a compatibilizer. This present invention also relates to a thermoplastic elastomer article in which a hard thermoplastic matrix is made of a thermoplastic component that includes polyamide, polyethylene terephthalate and a compatibilizer, and soft elastomeric domains distributed within the hard thermoplastic matrix and made of an elastomer. | 2014-03-13 |
20140073741 | Oxygen Scavenger System In A Polyolefin Matrix - An oxygen scavenging polyolefin composition and methods of making thereof are described herein. In one approach, the composition includes a continuous non-polar polyolefin matrix having oxygen scavenging domains dispersed therein. The oxygen scavenging domains include an oxidizable polymer, a transition metal catalyst or salt thereof, and a catalytic promoter effective to bind with oxygen passing through the continuous non-polar polyolefin matrix. The oxygen scavenging domains forming a discrete polar region within the continuous non-polar polyolefin matrix. The composition further includes a polymeric compatibilizer having a polar moiety and a non-polar moiety and in amounts effective to uniformly disperse the polar oxygen scavenging domains in the continuous non-polar polyolefin matrix. | 2014-03-13 |
20140073742 | UNSATURATED POLYESTER RESIN COMPOSITION - The present invention relates to unsaturated polyester resin compositions comprising (a) an unsaturated polyester, (b) a vinyl group containing organic compound as reactive diluent and (c) a tertiary aromatic amine, wherein the resin composition further comprises (d) a compound according to formula (1) as reactive diluent | 2014-03-13 |
20140073743 | POLY(OCTYLCYANOACRYLATE)-POLYISOBUTYLENE POLYMER CONETWORK, METHOD FOR THE PRODUCTION THEREOF AND USES THEREOF - A polymer conetwork formed from the polymerization reaction of octyl-cyanoacrylate and a tri-telechelic star polymer comprising polyisobutylene terminated with cyanoacrylate groups (Ø(PIB-CA) | 2014-03-13 |
20140073744 | METHOD FOR PRODUCING CHLORINATED HYPERBRANCHED POLYMER - There is provided a novel production method of a chlorinated hyperbranched polymer that is optically stable and is capable of derivatizing the chlorinated hyperbranched polymer into various compounds. A production method of a chlorinated hyperbranched polymer for producing a chlorinated hyperbranched polymer of Formula (1): | 2014-03-13 |
20140073745 | Biodegradable Polymer Blend - A fully degradable and a compostable polyester based blend that is free from non- degradable organic or inorganic additives such as nucleating agents and the like. The thermal properties of the present blend are configured for optimised flow rate during process moulding via a ‘flow rate enhancing component’ being a relative low molecular weight biodegradable polyester. The blend also provides a resultant moulded article having the appropriate mechanical, physical and chemical properties including greatly improved toughness over existing PLA based blends. This is achieved by incorporating a ‘toughening component’ within the blend being a relatively high molecular weight component relative to the flow rate enhancing component. | 2014-03-13 |
20140073746 | METHOD FOR PRODUCING CARBONACEOUS MATERIAL-POLYMER COMPOSITE MATERIAL, AND CARBONACEOUS MATERIAL-POLYMER COMPOSITE MATERIAL - Provided are a method for producing a carbonaceous material-polymer composite material in which a polymer can be easily grafted to a carbonaceous material and a carbonaceous material-polymer composite. | 2014-03-13 |
20140073747 | POLYLACTIC ACID, RESIN COMPOSITION, AND RESIN MOLDED PRODUCT - A polylactic acid has a terminal-modified structure represented by the following formula (1): | 2014-03-13 |
20140073748 | METHOD FOR IMPROVING ETHYLENE POLYMERIZATION REACTIONS - The present invention relates to a method for initiating an ethylene polymerization reaction in an ethylene polymerization loop reactor. More particularly, the invention relates to the timing upon which hydrogen is introduced into the ethylene polymerization loop reactor. The catalysts used in the ethylene polymerization reaction according to present invention are preferably metallocene catalysts. | 2014-03-13 |
20140073749 | PROCESS FOR PREPARING WATER SOLUBLE POLYMERS WITH NO INSOLUBLE GELS AND LOW LEVELS OF RESIDUAL MONOMERS - The invention provides a method and apparatus for continuously feeding wet gel polymers into a drying step of a dry polymer synthesis operation. A number of pistons are arranged having inner chambers through which monomers and other reagents are fed and polymerized into wet gel polymers. Each piston operates according to a coordinated schedule so that as one piston finishes extruding polymer into the drying step, a second piston has completed polymerizing more polymer and continues to feed more polymer without interruption. The then finished is re-fed more reagents so as to be ready again when needed next. As a result, cost effective continuous feeding can be achieved without the contamination and impurity problems that have plagued previous attempts to accomplish this. | 2014-03-13 |
20140073750 | CONTROLLED MORPHOLOGY HIGH ACTIVITY POLYOLEFIN CATALYST SYSTEM - A high activity polyolefin catalyst system comprising titanium containing pro-catalyst component, a co-catalyst component and an external electron donor compound is provided wherein the high activity polyolefin catalyst system is having controlled morphology and less fines. At least one embodiment of the present invention is more directed to provide a method for the preparation of titanium containing pro-catalyst component from solid spherical shaped magnesium containing pro-catalyst precursor wherein the spherical morphology of the pro-catalyst precursor is maintained through out the reaction in order to achieve titanium-containing pro-catalyst having controlled morphology. The polymerization of lower olefins in the presence of high activity polyolefin catalyst having controlled morphology provides polyolefins with minimal polymer fines. | 2014-03-13 |
20140073751 | Processes For The Preparation Of High-Cis Polydienes - The present disclosure is directed towards a solution or bulk polymerization process for preparing high-cis polydienes that utilizes at least one vinyl aromatic compound as a molecular weight regulator. The disclosed solution or bulk polymerization processes are useful for preparing high-cis polydienes with a Mooney viscosity between 30 and 55 while allowing the use of lower amounts of catalyst. | 2014-03-13 |
20140073752 | Living Coordinative Chain Transfer Polymerization with Dynamic Counterion Exchange - Disclosed is a method of producing a polyolefin composition comprising contacting a metal alkyl and a first olefin monomer, then adding a first co-catalyst, a second co-catalyst, a pre-catalyst, and a second olefin monomer. The method allows for the production of a series of copolymers with tunable incorporation ratios of the first olefin monomer. The method also allows for the production of polyolefins of low molecular weights and narrow molecular weight distributions. | 2014-03-13 |
20140073753 | PROCESS FOR MANUFACTURE OF CONJUGATED POLYMER COMPOSITIONS FOR SOLAR CELL APPLICATIONS - The present disclosure relates to a process for the synthesis of a conducting polymer comprising a benzothiadiazole acceptor and indeno-fluorene donor of formula [IV]. | 2014-03-13 |
20140073754 | ORGANIC SEMICONDUCTOR COMPOUND AND ORGANIC THIN FILM INCLUDING THE ORGANIC SEMICONDUCTOR COMPOUND - An organic semiconductor compound may be represented by the above Chemical Formula 1 or Chemical Formula 2, and an organic thin film may include the organic semiconductor compound according to Chemical Formula 1 or 2. | 2014-03-13 |
20140073755 | CONJUGATED POLYMER COMPOSITION FOR SOLAR CELL AND FLEXIBLE ELECTRONICS APPLICATIONS - A polymer composition for solar cell and flexible electronics devices, where the polymer is a p-type conducting polymer. The p-type polymer comprises a benzothiadiazole acceptor and indeno-fluorene donor. Further, a solar cell and flexible electronic device article may be made from the disclosed polymer. | 2014-03-13 |
20140073756 | Hydrophobic Diacrylamide Compound - A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound. | 2014-03-13 |
20140073757 | POLYCARBONATE RESIN AND TRANSPARENT FILM COMPRISING THE SAME - The polycarbonate resin of the present invention comprises a structural unit derived from a dihydroxy compound represented by a specific formula (1), a structural unit derived from a dihydroxy compound represented by a specific formula (2), and a structural unit derived from a dihydroxy compound represented by any one of specific formulae (3) to (6), wherein the content of structural units derived from dihydroxy compounds represented by the specific formulae (3) to (6) is within a specific range based on the total of structural units derived from dihydroxy compounds in the polycarbonate resin. | 2014-03-13 |
20140073758 | POLYCONDENSATION CATALYST FOR PRODUCING POLYESTER AND PRODUCTION OF POLYESTER USING THE POLYCONDENSATION CATALYST - The invention provides a polycondensation catalyst for producing polyester by an esterification reaction or a transesterification reaction between a dicarboxylic acid or an ester-forming derivative thereof and a glycol, wherein the polycondensation catalyst comprises particles of a solid base having on the surfaces an inner coating layer of titanic acid in an amount of from 0.1 to 50 parts by weight in terms of TiO | 2014-03-13 |
20140073759 | Purification of Insulin - The present application discloses a chromatographic process for separating protein components of a protein-containing solution, said solution comprising an insulin peptide and one or more di- or polyvalent metal ions, said insulin peptide being capable of self-association and/or structural change in the presence of di- or polyvalent metal ions, said process comprising the steps of: a) applying the protein-containing solution to a column of a chromatographic solid phase material, wherein the loading of the insulin peptide is at least 6.0 g per litre of column volume (g/L | 2014-03-13 |
20140073760 | USE OF AN ANG-(1-7) RECEPTOR AGONIST IN ACUTE LUNG INJURY - The present invention refers to a peptidic or non-peptidic angiotensin(1-7) (Ang-(1-7)) receptor agonist, preferably a Mas receptor agonist, for the prevention and/or treatment of acute lung injury, preferably acute respiratory distress syndrome. | 2014-03-13 |
20140073761 | CONJUGATES CONTAINING HYDROPHILIC SPACER LINKERS - Described herein are compositions and methods for use in targeted drug delivery using cell receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in imaging, diagnosing, and/or treating diseases and disease states caused by pathogenic cell populations. | 2014-03-13 |
20140073762 | MULTIPLE STATIONARY PHASE MATRIX AND USES THEREOF - The present invention generally provides a separation matrix comprising at least two stationary phases and a stationary phase comprising at least one chiral modality and at least one achiral modality. Also provided are methods of using the separation matrix or the stationary phase to separate enantiomers of one or more chiral molecules. | 2014-03-13 |
20140073763 | PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING - Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them. | 2014-03-13 |
20140073764 | UNNATURAL AMINO ACIDS COMPRISING A CYCLOOCTYNYL OR TRANS-CYCLOOCTENYL ANALOG GROUP AND USES THEREOF - The present invention relates to unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and having formula (I) or an acid or base addition salt thereof. The invention also relates to the use of said unnatural amino acids, kits and processes for preparation of polypeptides that comprise one or more than one cyclooctynyl or trans-cyclooctenyl analog group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising an azide, nitrile oxide, nitrone, diazocarbonyl or 1,2,4,5-tetrazine group. | 2014-03-13 |
20140073765 | REGENERATION AND REPAIR OF MESENCHYMAL TISSUE USING AMELOGENIN - A method of treating an injury to or a disease of a skeletal joint ligament is disclosed. The method comprises contacting the skeletal joint ligament or tendon of the subject with a therapeutically effective amount of amelogenin, wherein the amelogenin is not comprised in a scaffold, thereby treating the injury to or disease of the skeletal joint ligament or tendon. | 2014-03-13 |
20140073766 | METHODS FOR PURIFYING IgY ANTIBODIES - A method for purifying IgY antibodies is provided. The method comprises precipitating IgY antibodies from a sample by contacting the sample with a precipitating agent; and differentially precipitating the IgY antibodies obtained in step (a) using the same or different precipitating agent to separate IgY(Fc) and IgY(ΔFc) antibodies. | 2014-03-13 |
20140073767 | PROTEIN COMPLEXES AND METHODS OF MANUFACTURING BISPECIFIC ANTIBODIES USING THE PROTEIN COMPLEXES - A protein complex comprising (i) a first fusion protein comprising (a) a first polypeptide that comprises a first antigen-binding site and (b) a first binding protein linked to a terminus of the first polypeptide; and (ii) a second fusion protein comprising (a) a second polypeptide that comprises a second antigen-binding site and (b) a second binding protein linked to a terminus of the second polypeptide, wherein the protein complex comprises an amino acid sequence that enables cleavage between the first polypeptide and the first binding protein, and/or between the second polypeptide and the second binding protein, as well as a method for preparing a bi-specific antibody and related methods and compositions. | 2014-03-13 |
20140073768 | OPTIMIZED Fc VARIANTS - The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants. | 2014-03-13 |
20140073769 | ASYMMETRIC POROUS ADSORPTIVE BEAD - The present invention relates to an asymmetric chromatography media suitable for separations applications, particularly as packed bed, fluidized bed or magnetized bed chromatography media. In certain embodiments, the asymmetric chromatography media comprises asymmetric particles, preferably beads, having at least two distinct, controlled pore size distributions. Preferably one of the distinct pore size distributions is in an internal region of the particle, and the other is in an external region or coating on the particle. These distinct pore size distributions can be modified with uniform or alternatively unique functional groups or mixtures of functional groups. The present invention allows for the control over pore size distribution within an asymmetric porous particle by providing a distinct internal region, preferably in the form of a bead, and a distinct external region, preferably in the form of a coating on the bead. | 2014-03-13 |
20140073770 | Process for preparation of ketolide intermediates - The inventions discloses a process for preparation of compounds of Formula (IX), Wherein, R is C | 2014-03-13 |
20140073771 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES - New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent. an aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP. | 2014-03-13 |
20140073772 | Biotechnological Production of Chondroitin - Chondroitin is produced by culturing a recombinant microorganism which is obtained by inactivation of a gene encoding an enzyme responsible for addition of fructose residues to the linear chondroitin polysaccharide in a microorganism producing a fructosylated derivative of chondroitin. | 2014-03-13 |
20140073773 | METHOD FOR PRODUCING ALKALI CELLULOSE - The present invention relates to a method for producing an alkali cellulose with suppressed decrease in the degree of polymerization as well as with small use amount of a basic compound, and to a method for producing a cellulose ether by using the alkali cellulose thus obtained. Provided by the present invention are: (A) a method for producing an alkali cellulose, comprising Step 1 wherein a cellulose-containing raw material is pulverized in the presence of 0.6 to 1.5 mol of a basic compound relative to 1 mol of an anhydroglucose unit that constitutes a cellulose in the said cellulose-containing raw material and under the condition in which the water content therein relative to the cellulose in the cellulose-containing raw material is 10% or less by mass thereby obtaining a cellulose powder mixture having the median diameter of the cellulose-containing raw material made 150 μm or less and Step 2 wherein water content therein is adjusted in the range of 30 to 100% by mass relative to the cellulose by adding water to the cellulose powder mixture thereby obtaining the alkali cellulose in the powder form; and (B) a method for producing a cellulose ether by reacting the alkali cellulose produced by the foregoing production method with an etherification agent. | 2014-03-13 |
20140073774 | PROCESS FOR TREATING CELLULOSE AND CELLULOSE TREATED ACCORDING TO THE PROCESS - The present invention relates to a process for purifying a slurry comprising cellulose, such as microfibrillated cellulose, wherein the process comprises the following steps: —providing a slurry comprising cellulose and liquid, —subjecting the slurry to an electric field inducing the liquid of the slurry to flow, —separating the liquid from the cellulose thus obtaining a liquid depleted slurry, —adding a washing liquid, such as an organic solvent, to the liquid depleted slurry—subjecting the liquid depleted slurry to an electric field inducing the washing liquid of the slurry to flow and—separating the washing liquid from the cellulose, thus obtaining a purified cellulose. The invention also relates to cellulose such as microfibrillated cellulose obtainable from said process. | 2014-03-13 |
20140073775 | CELLULOSE PHOSPHATE POWDER PRODUCT AND PROCESS FOR MANUFACTURE THEREOF, AND APPLICATION TO REMOVAL OF CONTAMINANTS FROM AQUEOUS SOLUTIONS - A process for producing a cellulose based sorbent material for the removal of water soluble contaminants from water and other aqueous solutions comprising reacting one or more biomass based cellulose containing raw materials with dilute phosphoric acid where the reaction mixture containing said cellulose containing materials is heated to a reaction temperature and after completion of the reaction time, separation of the dilute phosphoric acid solution from the remaining insoluble raw material, neutralisation of the solution by means of a suitable neutralising agent resulting in precipitation of the modified cellulose, and then separating, washing and removing excess water from the resultant precipitate. | 2014-03-13 |
20140073776 | CELLULOSE NANOFIBERS AND METHOD FOR PRODUCING SAME, COMPOSITE RESIN COMPOSITION, AND MOLDED BODY - Cellulose nanofibers have an average degree of polymerization of 600 or more to 30000 or less, an aspect ratio of 20 or more to 10000 or less, an average diameter of 1 nm or more to 800 nm or less, and an Iβ-type crystal peak in an X-ray diffraction pattern, in which a hydroxyl group in the cellulose nanofibers is esterified and has a modification degree of 1.0 or more based on all of the hydroxyl groups. | 2014-03-13 |
20140073777 | METHOD FOR PRODUCING ALKALI CELLULOSE - The present invention relates to a method for producing an alkali cellulose with suppressed decrease in the degree of polymerization as well as with small use amount of a basic compound, and to a method for producing a cellulose ether by using the alkali cellulose thus obtained. Provided by the present invention are: (A) a method for producing an alkali cellulose, comprising Step 1 wherein a cellulose-containing raw material (I) is treated by a pulverizing machine thereby obtaining a cellulose-containing raw material (II) which contains a cellulose having crystallinity in the range of 10 to 55% and Step 2 wherein the cellulose-containing raw material (II) obtained in Step 1 is added by a basic compound with the amount thereof being in the range of 0.6 to 1.5 mol relative to 1 mol of an anhydroglucose unit that constitutes the said cellulose as well as by water with the amount thereof being in the range of 20 to 100% by mass relative to the said cellulose thereby obtaining the alkali cellulose; and (B) a method for producing a cellulose ether by reacting the alkali cellulose produced by the foregoing production method with an etherification agent. | 2014-03-13 |
20140073778 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION - The present invention relates to hydroxyalkyl starch conjugates, a method for preparing the same, the hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent and the cytotoxic agent comprising at least one tertiary hydroxyl group, wherein the hydroxyalkyl starch is linked via said tertiary hydroxyl group to the cytotoxic agent. The conjugates according to the present invention have a structure according to the following formula HAS′(-L-M) | 2014-03-13 |
20140073779 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION - The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M) | 2014-03-13 |
20140073780 | MULTIMERIC DUAL-MODALITY BREAST CANCER DIAGNOSTIC AGENTS - The present invention describes dual-modality probes. In particular, the present invention discloses hydroxyapatite specific multimeric bisphosphonate dual-modality MRI and optical probes. | 2014-03-13 |
20140073781 | PROCESS FOR OBTAINING A CHARGE OF HEXANITROHEXAAZAISOWURTZITANE CRYSTALS HAVING A ROUNDED MORPHOLOGY; CHARGE AND CORRESPONDING ENERGETIC MATERIAL - The present invention provides a process for obtaining a charge of hexanitrohexaazaisowurtzitane crystals having rounded morphology. It also provides said charge, the energetic material comprising it, and a process for manufacturing said material. Said process for obtaining said charge comprises:
| 2014-03-13 |
20140073782 | Substituted Quinazoline and Pyrido-Pyrimidine Derivatives - The present application provides novel substituted quinazoline and pyrido-pyrimidine compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating PI3K and/or mTOR activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the PI3K/AKT/mTOR pathway. Advantageously, these compounds perform as dual PI3K/mTOR inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer. | 2014-03-13 |
20140073783 | NEPRILYSIN INHIBITORS - In one aspect, the invention relates to compounds having the formula: | 2014-03-13 |
20140073784 | AROMATIC HETEROCYCLIC DERIVATIVE, MATERIAL FOR ORGANIC ELECTROLUMINESCENCE ELEMENT, AND ORGANIC ELECTROLUMINESCENCE ELEMENT - An organic EL device includes an anode, an emitting layer, an electron transporting zone and a cathode in this sequence, in which the electron transporting zone contains an aromatic heterocyclic derivative represented by a formula (1) below. In the formula (1), X | 2014-03-13 |
20140073785 | Methods for Forming Protected Organoboronic Acids - Described are methods of forming protected boronic acids that provide in a manner that is straightforward, scalable, and cost-effective a wide variety of building blocks, such as building blocks containing complex and/or pharmaceutically important structures, and/or provide simple or complex protected organoboronic acid building blocks. A first method includes reacting an imino-di-carboxylic acid and an organoboronate salt. A second method includes reacting a N-substituted morpholine dione and an organoboronic acid. | 2014-03-13 |
20140073786 | CYCLOHEXENYL NUCLEIC ACIDS ANALOGS - The present disclosure describes cyclohexenyl nucleic acid analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, cyclohexenyl nucleic acid analogs are provided, having one or more chiral substituents, that are expected to be useful for enhancing properties of oligomeric compounds including nuclease resistance and binding affinity. In some embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. | 2014-03-13 |
20140073787 | PREPARATION OF 3-[2-[4-((6-FLUORO-1, 2-BENZISOXAZOL-3-YL)-L-PIPERIDINYL)-6, 7, 8, 9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDO[ 1, 2-A]-PYRIMIDIN-4-ONE (PALIPERIDONE) AND PALIPERIDONE PALMITATE. - An improved process for the synthesis of 3-[2-[4-((6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one (Paliperidone) and Paliperidone Palmitate through a novel intermediate (2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido [1,2-a]pyrimidine-4-one Palmitate ester. | 2014-03-13 |
20140073788 | Preparation of Polymer Conjugates of Therapeutic, Agricultural, and Food Additive Compounds - Disclosed is a process for preparing polymer conjugates of agricultural, therapeutic, and food additive compounds using Mitsunobu conditions. | 2014-03-13 |
20140073789 | Biological Buffers with Wide Buffering Ranges - Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability. | 2014-03-13 |
20140073790 | NOVEL FLUOROERGOLINE ANALOGS - Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT | 2014-03-13 |
20140073791 | NOVEL SALTS OF SITAGLIPTIN, PROCESS FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITION THEREOF - The present invention relates to pharmaceutically acceptable acid addition salts of sitagliptin, in particular anti-oxidant acid addition salts of sitagliptin and a process for its preparation. The present invention also provides a pharmaceutical composition using the pharmaceutically acceptable acid addition salts of sitagliptin. | 2014-03-13 |
20140073792 | NITROGENATED HETEROCYCLIC COMPOUND AND AGRICULTURAL OR HORTICULTURAL FUNGICIDE - An agricultural or horticultural fungicide contains as an active ingredient thereof at least one compound selected from the group consisting of nitrogenated heterocyclic compounds represented by formula (I) (wherein, R represents a group represented by CR | 2014-03-13 |
20140073793 | Germanium-containing camptothecin analogues - The present invention discloses: (i) the novel germanium-containing camptothecin compound, 7[2′-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts thereof; (ii) methods of synthesis of said novel germanium-containing camptothecin compound, 7[2′-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts; (iii) pharmaceutically-acceptable formulations comprising said novel germanium-containing camptothecin compound, 7[2′-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts thereof; and (iv) methods of administration of said novel germanium-containing camptothecin compound, 7[2′-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts thereof to subjects in need thereof, including subjects with cancer. | 2014-03-13 |
20140073794 | HIGH TRANSMISSIONAL YELLOW DYE FOR LCD AND SYNTHETIC METHOD THEREOF - The present invention relates to high transmission yellow dye for LCD, dye dispersion comprising the dye, coloring composite comprising the dye dispersion, color filter comprising the coloring composite, and synthetic method thereof. | 2014-03-13 |
20140073795 | Process for the preparation of substituted pyrimidine derivatives - The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H | 2014-03-13 |
20140073796 | NITROPYRIDINYL ETHYLENEIMINE COMPOUND, THE PHARMACEUTICAL COMPOSITION CONTAINING IT, THE PREPARATION METHOD AND USE THEREOF - The present invention discloses a nitropyridinyl ethyleneimine compound as shown in the formula I and a preparation method of the same, as well as use of the compound in manufacture of a prodrug and in manufacture of a drug for treating a tumor. | 2014-03-13 |
20140073797 | PROCESSES FOR THE PREPARATION OF 2-FLUORO 6-11 BICYCLIC ERYTHROMYCIN DERIVATIVES - The present invention relates to processes and intermediates for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (X-c): | 2014-03-13 |
20140073798 | IRIDIUM COMPLEXES DEMONSTRATING BROADBAND EMISSION THROUGH CONTROLLED GEOMETRIC DISTORTION AND APPLICATIONS THEREOF - Iridium compounds and their uses are disclosed herein. For example, carbazole containing iridium compounds are disclosed. The compounds are useful in many devices, including, but not limited to, electroluminescent devices. | 2014-03-13 |
20140073799 | THIENOPYRAZOLE DERIVATIVE HAVING PDE7 INHIBITORY ACTIVITY - To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): | 2014-03-13 |
20140073800 | ONO PINCER LIGANDS AND ONO PINCER LIGAND COMPRISING METAL COMPLEXES - Embodiments of the invention are directed to ONO pincer ligands that can be in a trianionic, protonated or protonated equivalent form. The ONO pincer ligand can be combined with a transition metal comprising compound to form an ONO pincer ligand comprising transition metal complex. By choice of the ONO pincer ligand structure, the steric and electronic properties of the transition metal complexes therefrom can be controlled. The ONO pincer ligands comprise a central nitrogen atom that is disubstituted with a pair of three atom comprising bridges where the three atoms are three sp | 2014-03-13 |
20140073801 | PYRROLIDINE DERIVATIVES AS SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF - Disclosed are compounds of formula (I): | 2014-03-13 |
20140073802 | MALEIMIDYL POLYMER DERIVATIVES - The present invention provides, among other things, compounds that include a water-soluble and non-peptidic polymer as well as a maleimidyl group. The compounds are useful as, among other things, polymeric reagents. | 2014-03-13 |
20140073803 | RADIOTRACER PRECURSOR AND METHOD FOR PREPARING THE SAME - A precursor SnBZM for a dopamine receptor radiotracer and a method for preparing the same are revealed. The precursor includes a tributyltin group (Bu | 2014-03-13 |
20140073804 | PROCESS FOR THE PREPARATION OF ZANAMIVIR - The present invention provides a process for preparing 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-enonic acid Formula (I), which process comprises reducing compound of Formula (IV) by Lindlar catalyst in presence of hydrogen to obtain compound of Formula (V). reacting compound of Formula (V) with pyrazole-1H-carboxamidine or its suitable salt to obtain compound of Formula (VIII). hydrolyzing the compound of Formula (VIII) to give compound of Formula (I). The present invention also provides compounds of formula (VIII) which may be used in the synthesis of zanamivir. The present invention also provides process for preparing compound of formula (VIII) and process involving the use of Formula (VIII), including in the synthesis of zanamivir. | 2014-03-13 |
20140073805 | PROCESS FOR MANUFACTURING ESTERS OF 2,5-FURANDICARBOXYLIC ACID - The present invention relates to an improved process for manufacturing of esters of 2,5-furandicarboxylic acid (FD-CA-esters) by reacting 2,5-furandicarboxylic acid (FDCA) with one or more alcohols in the presence of a heterogeneous catalyst. The use of the heterogeneous catalyst, which may be a Bronsted or Lewis acid, allows for production of high yields of FDCA esters. Furthermore, the catalyst can conveniently be recycled after completion of the reaction. | 2014-03-13 |
20140073806 | METHOD FOR PRODUCING EPOXY COMPOUND - To provide a method for producing an epoxy compound having fewer residual quaternary salt compound by removing the quaternary salt compound from an organic solution containing an epoxy compound and the quaternary salt compound. | 2014-03-13 |
20140073807 | PROCESSES FOR PREPARATION OF OIL COMPOSITIONS - The present invention is directed to processes for preparing oil compositions having a high concentration of poly-unsaturated fatty acids and oil compositions having a low concentration of α-linolenic acid. In addition, the present invention is directed to processes for preparing oil compositions having advantageous stability characteristics. | 2014-03-13 |
20140073808 | METHOD FOR PREPARING A POLYORGANOSILOXANE - A method for preparing a polyorganosiloxane, wherein the method includes a step of subjecting at least one organic silicon compound having at least one —OX group bonding to a silicon atom in the molecule, wherein X is a hydrogen atom, an alkyl group having 1 to 10 carbon atoms or an alkoxyalkyl group having 2 to 10 carbon atoms, to a condensation reaction in the presence of a catalyst, wherein the catalyst is one obtained by surface treating at least one selected from the group consisting of hydroxides of elements in Group II of the periodic table, hydrates of hydroxides of elements in Group II of the periodic table and oxides of elements in Group II of the periodic table with a silane coupling agent. | 2014-03-13 |
20140073809 | PREPARATION METHOD FOR RIVASTIGMINE, INTERMEDIATES THEREOF, AND PREPARATION METHOD FOR SAID INTERMEDIATES - The present invention provides the preparation method for (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate (formula X compound), the preparation methods for its intermediates (S)-1-(3-methoxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium (formula VI compound), (S)-1-(3-hydroxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium (formula VIII compound) and (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium (formula IX compound), as well as the method for using above mentioned formula IX compound to prepare rivastigmine which can be used for the treatment of Alzheimer's disease. The preparation method for rivastigmine has a reasonable synthetic design with convenient source of raw materials and high total yield, and the product resulted has high chemical and optical purity, which makes it easy for large-scale. industrial production. | 2014-03-13 |
20140073810 | PHOTOREACTIVE MONOMERS - Photoreactive monomer which has (i) at least one free-radically polymerizable C—C double bond, (ii) at least one hydrophilic group selected from an ethylene glycol group and a polyethylene glycol group having at least 2 ethylene glycol units and (iii) at least one photoreactive group, the photoreactive group being a photoenolizable carbonyl group, and also a method for preparing the photoreactive monomers. | 2014-03-13 |
20140073811 | METHOD FOR PRODUCING TOLYLENE DIISOCYANATE - A method for producing tolylene diisocyanate includes: mixing a first diaminotoluene containing 2,4-diaminotoluene and 2,6-diaminotoluene at a first isomer ratio and a second diaminotoluene containing 2,4-diaminotoluene and/or 2,6-diaminotoluene at a second isomer ratio that is different from the first isomer ratio so as to prepare mixed diaminotoluene; producing tolylene dicarbamate by reaction of the mixed diaminotoluene, urea and/or N-unsubstituted carbamic acid ester and alcohol; and thermally decomposing the tolylene dicarbamate. | 2014-03-13 |
20140073812 | Process for Making Acrylic Acid by Integrating Acetic Acid Feed Stream from Carbonylation Process - In one embodiment, the invention is to a process for producing acrylic acid, comprising the step of providing from a distillation column in a carbonylation process a purified acetic acid stream comprising at least 0.15 wt % water. The process further comprises the step of condensation acetic acid of the purified acetic acid stream and an alkylenating agent in the presence of a catalyst and under conditions effective to form a crude acrylate product comprising acrylic acid and water. Acrylic acid is recovered from the crude acrylate product. | 2014-03-13 |
20140073813 | Heat Integration of Carbonylation and Aldol Condensation Reaction Processes - In one embodiment, the invention is to a process for producing an acrylic acid, comprising the step of reacting, in a carbonylation system, carbon monoxide with at least one reactant in a reaction medium under conditions effective to produce a crude alkanoic acid stream comprising alkanoic acid. Preferably, the reaction is an exothermic carbonylation reaction. The process further comprises the step of removing from the carbonylation system at least a portion of heat generated by the carbonylation reaction and transferring a portion of the heat to a heat transfer system that utilizes at least one steam condensate stream. The process further comprises the step of conveying at least a portion of the heat transferred to the heat transfer system of the condensation reaction zone and/or the condensation separation zone. | 2014-03-13 |
20140073814 | AMINOETHYLATION PROCESS HAVING IMPROVED YIELD OF ARYLOXYALKYLENE AMINE COMPOUNDS AND REDUCED UREA BY-PRODUCTS - Disclosed is a process for preparing an aryloxyalkylene amine compound via an aminoethylation reaction comprising: a) reacting an aromatic hydroxyl compound in the presence of a basic catalyst with a 2-oxazolidinone compound of the formula II to form an intermediate reaction product; | 2014-03-13 |
20140073815 | AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED WITH A CYCLIC GROUP - This invention provides a compound of the formula (I): | 2014-03-13 |
20140073816 | PROCESS FOR THE PREPARATION OF A STABLE POLYMORPHIC FORM OF ATOVAGUONE - The present invention provides a process for the preparation of a stable polymorph III of Atovaquone exhibiting characteristic peaks (expressed in degrees 2θ±0.2°θ) at about 6.9, 9.6, 14.1, 14.7, 17.0, 18.5, 19.1, 19.9, 20.3, 22.0, 22.6, 23.2, 24.2, 26.8, and 28.5, which comprises: (a) providing a sample of Atovaquone particles; (b) heating the sample of Atovaquone particles at a minimal temperature of between 140° C. to 160° C. depending on the particle size of the sample; and (c) cooling the sample to obtain the stable polymorphic form of Atovaquone. | 2014-03-13 |
20140073817 | METHOD FOR PREPARING MENTHONE FROM ISOPULEGOL - The present invention relates to a method for preparing menthone, starting from isopulegol, using specific homogeneous catalysts. | 2014-03-13 |
20140073818 | Method for hydroxylating phenols and phenol ethers - A method for hydroxylating phenols and phenol ethers using hydrogen peroxide and specifically, a method for hydroxylating phenol using hydrogen peroxide. The method for hydroxylating a phenolic substrate selected from a phenol or a phenol ether by reacting such phenolic substrate with hydrogen peroxide in the presence of an acid catalyst comprises the following steps, implemented consecutively or simultaneously: a first step consisting of mixing a phenolic substrate with a hydrogen peroxide solution under conditions in which the temperature is sufficient for the initial phenolic substrate to remain liquid and for minimizing the conversion rate of the hydrogen peroxide; a second step consisting of carrying out the phenolic substrate hydroxylation reaction under adiabatic conditions, the acid catalyst being added at the mixing stage and/or at the beginning of the hydroxylation reaction; and a third step, if necessary, consisting of recovering the hydroxylated product. | 2014-03-13 |
20140073819 | METHOD FOR PREPARING 2-METHYL-4-PHENYLBUTAN-2-OL - For the preparation of 2-methyl-4-phenylbutan-2-ol, a benzylmagnesium halide is reacted with isobutylene oxide. 2-Methyl-4-phenylbutan-2-ol is suitable as a fragrance. | 2014-03-13 |
20140073820 | PROCESSES AND SYSTEMS FOR THE FERMENTATIVE PRODUCTION OF ALCOHOLS - The present invention relates to the fermentative production of alcohols including ethanol and butanol, and processes for improving alcohol fermentation employing in situ product removal methods. | 2014-03-13 |
20140073821 | C HEAVY OIL COMPOSITION AND METHOD FOR PRODUCING SAME - The present invention provides a method for producing a C heavy oil composition which unlikely forms sludge, has excellent ignitability and combustibility, and enable the stable operation of a combustion device such as an external combustion device, a diesel device, and a gas turbine device. The method of the present invention is comprises method for producing a C heavy oil composition with a bicyclic aromatic hydrocarbon content of 10 percent by volume or more and 45 percent by volume or less, comprising blending a cracked reformed base oil with a total aromatic content of 80 percent by volume or more and a 15° C. density of 0.90 to 1.20 g/cm | 2014-03-13 |
20140073822 | Rotating Fluidized Bed Catalytic Pyrolysis Reactor - Reactors for the pyrolysis of pyrolyzable matter, pyrolysis systems incorporating the reactors and methods of using the reactors are provided. Also provided are systems and methods for integrating the pyrolysis and hydrodeoxygenation of pyrolyzable matter. The pyrolysis reactors create a horizontally rotating, fluidized-bed to which pyrolyzable matter, such as biomass, may be converted via pyrolysis into liquid fuels and/or value-added chemicals. | 2014-03-13 |
20140073823 | GENERATING DEOXYGENATED PYROLYSIS VAPORS - The present disclosure relates generally to novel biomass pyrolysis processes and systems that decrease entrainment of char and other contaminants with the pyrolysis vapors. | 2014-03-13 |
20140073824 | PYROLYSIS VAPOR RAPID FILTRATION AND CONVERSION TO FUEL - The present disclosure pertains to biomass pyrolysis processes and systems that decrease entrainment of char and other contaminants in the pyrolysis vapors by filtering the vapors in a heated container comprising a moving bed granular filter (MBGF), which in turn, comprises granular heat carrier. The granular heat carrier is heated within the MBGF and fed directly to the pyrolysis reactor, optionally along with filtered solids such as char. In certain embodiments, the MBGF additionally comprises at least one upgrading catalyst that contacts the vapors to produce a hydrocarbon mixture fungible with a petroleum-derived transportation fuel, a hydrocarbon transportation fuel component, or mixtures thereof. | 2014-03-13 |
20140073825 | FIELD REPLACEABLE MULTIFUNTIONAL CARTRIDGE FOR WASTE CONVERSION INTO FUEL - Disclosed herein is a field replaceable multifunction cartridge for the conversion of composite high molecular weight hydrocarbon vapours, extracted from homogenous or heterogeneous, segregated or unsegregated, wet or dry, unclean miscellaneous multi-feed waste input, to produce low molecular weight fractions of industriously combustible fuel products through catalytic cracking. The multifunction cartridge system is constructed in a modular fashion is capable of performing the catalytic, cleaning and scrubbing functions through the temperature range ranging from ambient to 500° C., owing to the high mechanical strength, low coefficient of expansion, resistance to thermal fatigue etc. | 2014-03-13 |
20140073826 | BASE OIL UPGRADING BY CO-FEEDING A KETONE OR BETA-KETO-ESTER FEEDSTOCK - This invention discloses a process for making high viscosity index lubricating base oils having a viscosity index of at least 110 by co-feeding a ketone or a beta-keto-ester feedstock with a lubricant oil feedstock directly to a hydrocracking unit to produce a hydrocracked stream. Then at least a portion of the hydrocracked stream is treated under hydroisomerization conditions to produce a high viscosity index lubricating base oil. The process may involve bypassing a hydrotreating or hydrofinishing step, which may result in improved efficiency and economics in producing high viscosity index lubricating base oils. | 2014-03-13 |
20140073827 | UPGRADING OF BIO-OIL USING SYNTHESIS GAS - A method for producing biofuel and other hydrocarbons from bio-oil is disclosed. The method does not require the use of hydrogen derived from fossil fuel. | 2014-03-13 |
20140073828 | SINC-CONTAINING METHANE AROMATIZATION CATALYST, METHOD OF MAKING A METHOD OF USING THE CATALYST - A catalyst for converting methane to aromatic hydrocarbons is described herein. The catalyst comprises an active metal or a compound thereof, zinc or a compound thereof and an inorganic oxide support wherein the active metal is added to the support as a metal oxalate. A method of making the catalyst and a method of using the catalyst are also described. | 2014-03-13 |
20140073829 | METHODS AND APPARATUSES FOR STABILIZING FUEL CONTAINING REACTIVE SODIUM METAL - A method of stabilizing a fuel containing a reactive sodium metal may include puncturing a cladding of a fuel pin enclosing the fuel containing the reactive sodium metal to form an injection passage and an extraction passage. A reaction gas may be injected into the fuel pin through the injection passage to react with the reactive sodium metal to form a stable sodium compound. A ratio of a product gas and a remaining quantity of the reaction gas exiting the fuel pin through the extraction passage is subsequently measured, wherein the product gas is a reaction product of the reaction gas and the reactive sodium metal within the fuel pin. Once the measured ratio indicates that a reaction between the reaction gas and the reactive sodium metal is complete, the injection passage and the extraction passage are sealed so as to confine the stable sodium compound within the fuel pin. | 2014-03-13 |
20140073830 | COMPOSITIONS AND METHODS FOR CONVERTING HAZARDOUS WASTE GLASS INTO NON-HAZARDOUS PRODUCTS - The present invention provides compositions and methods for converting hazardous waste glass into safe and usable material. In particular, the present invention provides compositions and methods for producing ceramic products from toxic-metal-containing waste glass, thereby safely encapsulating the metals and other hazardous components within the ceramic products. | 2014-03-13 |
20140073831 | RADIATION TREATMENT PLANNING SYSTEM - Optimal irradiation conditions determined by iterative calculation are based upon an operator-defined irradiating direction, prescription dose, and other conditions. Dose matrixes A and B relating doses to calculation points from a beam delivered to irradiating positions are divided into a dose matrix A | 2014-03-13 |
20140073832 | ANTI-TUMOR T CELL IMMUNITY INDUCED BY HIGH DOSE RADIATION - Cancer treatment is provided, by irradiating an individual with a localized, high single dose or short course of doses at a primary tumor site; collecting T cells from the individual after a period of time sufficient activation of an anti-tumor response; treating the individual with an effective dose of dose of chemotherapy; and reintroducing the T cell population back to the individual. | 2014-03-13 |
20140073833 | METHODS, SYSTEMS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR DETERMINING PATIENT SPECIFIC TREATMENT PLANNING MARGINS - Methods, systems and computer-readable storage media relate to determining individualized treatment planning margins. The methods may include processing motion data of a target obtained from at least one marker for one or more periods. Each period may include a plurality of time intervals. The processing may include processing the motion data to determine an isocenter for each time interval along at least one of the axes of motion. The axes can include the x axis, the y axis, and/or the z axis. The method may include determining motion prediction data for each of the at least one of the axes; and determining treatment planning margins for each of the at least one of the axes based on the motion prediction data. The individualized treatment margins can be smaller and more optimal because the treatment margins can incorporate patient specific patterns of motion of a target (e.g., an organ). | 2014-03-13 |
20140073834 | SYSTEM AND METHOD FOR RADIATION BEAM MEASUREMENT NORMALIZATION - A radiotherapy system includes a radiotherapy device, such as a LINAC, operable to direct a radiation beam from a head thereof during operation, a field detector positioned to be within the radiation beam during operation of the radiotherapy device and operable to generate a beam measurement signal, a reference detector positioned to be outside of the radiation beam during operation of the radiotherapy device and operable to generate a reference signal, and at least one computer in signal communication with the field detector and the reference detector and configured with software to normalize the beam measurement signal based on the reference signal and to output a normalized beam measurement. | 2014-03-13 |