11th week of 2009 patent applcation highlights part 43 |
Patent application number | Title | Published |
20090068591 | RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, NOVEL COMPOUND AND METHOD OF PRODUCING THE SAME, AND ACID GENERATOR - A compound represented by formula (I); and a compound represented by formula (b1-1): | 2009-03-12 |
20090068592 | POSITIVE RESIST COMPOSITION AND METHOD OF FORMING RESIST PATTERN - A positive resist composition including a resin component (A) which exhibits increased alkali solubility under action of acid and an acid-generator component (B) which generates acid upon exposure,
| 2009-03-12 |
20090068593 | Photosensitive Resin Composition - The present invention relates to a photosensitive resin composition comprising at least a thermoplastic elastomer (a), a photopolymerizable unsaturated monomer (b), and a photopolymerization initiator (c), characterized in that the thermoplastic elastomer (a) comprises at least vinyl aromatic hydrocarbon units, butadiene units, and alkylene units and contains alkylene units not less than 5 wt % and not more than 80 wt % with respect to the total amount of butadiene units and alkylene units. The present invention provides a photosensitive resin composition that simultaneously achieves excellent fine line reproducibility, ester solvent resistance, and prevention of cracks occurring on plate surface. | 2009-03-12 |
20090068594 | POSITIVE RESIST COMPOSITION AND METHOD FOR FORMING RESIST PATTERN - A positive resist composition for producing MEMS using an electron beam, the composition comprising a resin component (A) that displays increased alkali solubility under the action of acid, and an acid generator component (B) that generates acid upon irradiation, wherein the resin component (A) is a resin prepared by protecting a portion of all the hydroxyl groups within an alkali-soluble novolak resin with acid-dissociable, dissolution-inhibiting groups. | 2009-03-12 |
20090068595 | PHOTOSENSITIVE RESIN COMPOSITION, COMPOSITION FOR SOLDER RESIST, AND PHOTOSENSITIVE DRY FILM - A photosensitive resin composition which is excellent in storage stability required for one-part type compositions and in processability required for dry-film formation and gives a cured product suitable for FPC substrates or suspension substrates for hard-disc which each retains essential properties required for solder resists, such as heat resistance, water resistance, and electrical-insulation reliability, and has flexibility and low polluting property. The composition comprises: a compound which has a carbon-carbon double bond and carboxy group and is obtained by allowing a bisphenol type epoxy compound and an unsaturated monocarboxylic acid to react and then allowing a polybasic acid anhydride to undergo addition reaction with part or all of the secondary hydroxy groups of the reaction product; a urethane (meth)acrylate compound having a structure derived from a polycarbonate polyol structure; another polymerizable compound having a carbon-carbon double bond; and a photopolymerization initiator. | 2009-03-12 |
20090068596 | Negative-tone,Ultraviolet Photoresists for Fabricating High Aspect Ratio Microstructures - UV photoresist materials are disclosed, based on EPON 154 or EPON 165. Preferred embodiments, based on a composite of EPON 154 and EPON 165, spread evenly into a flat, uniform layer, even without spin-coating. The preferred embodiments bond strongly to all substrates, and are resistant to cracking and debonding following exposure and development. The preferred embodiments have high UV transmittance, which promotes uniform photopolymerization throughout a thick layer. Structures may be produced by UV lithography that have a sidewall quality that has previously been attainable only by photolithography with a collimated x-ray source. | 2009-03-12 |
20090068597 | EXPOSURE METHOD AND APPARATUS, AND ELECTRONIC DEVICE MANUFACTURING METHOD - An exposure method provided is a high-resolution and inexpensive method suitable for use in formation of a fine pattern for making up an electronic device. A diffraction grating is located in proximity to a wafer or the like for making up an electronic device, and illumination light with a predetermined incidence angle property is applied onto the diffraction grating to effect exposure on the wafer. The exposure is done while changing a positional relation between the semiconductor wafer and the diffraction grating according to need. | 2009-03-12 |
20090068598 | LASER PROCESSING APPARATUS AND LASER PROCESSING METHOD, DEBRIS COLLECTION MECHANISM AND DEBRIS COLLECTION METHOD, AND METHOD FOR PRODUCING DISPLAY PANEL - A laser processing apparatus is provided for patterning with laser light a resin film or a metal film formed on a substrate. The apparatus includes a laser light source; and a debris collection device having a transmission window through which the laser light is transmitted, a vortex generation mechanism generating a vortex gas flow by allowing gas to flow into a region near a laser light-irradiated area of the resin film or the metal film, and a screening device having an opening through which the incident laser light passes and screening a flow of debris. The mechanism is placed close to the resin film or the metal film on the substrate. Debris generated by laser light irradiation and before and after being stacked on the object film is entrained in the vortex gas flow generated by the vortex generation mechanism and is exhausted to outside through the screening device. | 2009-03-12 |
20090068599 | METHOD OF MANUFACTURING IMAGE SENSOR - Provided is a method of manufacturing image sensor capable of maximizing light condensing efficiency so that the light input through a micro-lens is condensed onto a light receiving element. According to the present invention, inner micro-lenses or a condensing efficiency of the light input through the micro-lens. Therefore, light condensing efficiency of the light condensed onto the light receiving element in the image sensor can be improved. | 2009-03-12 |
20090068600 | METHOD FOR ENHANCING OPTICAL STABILITY OF THREE-DIMENSIONAL MICROMOLDED PRODUCT - In order to enhance the optical stability of a three-dimensional micromolded product having optical transparency produced by irradiating a molded layer formed of a photosensitive resin composition provided on a transparent substrate with an actinic radiation from the transparent substrate side so that the quantity of light is varied along the plane of the transparent substrate and dissolving and removing the exposed molded layer in its uncured part with a developing solution, a potassium carbonate solution is used as the developing solution. This constitution can prevent a deterioration in transparency of the transparent three-dimensional micromolded product, incorporated in an optical component, with the elapse of time. That is, the optical stability of the optically transparent three-dimensional micromolded product can be enhanced. | 2009-03-12 |
20090068601 | Burner Pilot With Virtual Spinner - A method and apparatus for preheating a furnace during a warm-up phase of furnace operation. The furnace has main burners with a tubular fuel supply surrounded by a main combustion air duct defining an annular space between the supply and the duct that extends in an axial direction of the main burner. A pilot nozzle in the annular space extends in an axial direction of the burner towards an interior of the furnace and discharges readily ignitable fluid fuel jets through orifices in the nozzle toward the interior of the furnace. Combustion air from the duct is directed past the nozzle and is mixed with the fuel discharged from the orifices to form an ignitable mixture that is ignited to form the furnace heating pilot flame downstream of the nozzle. The flame is stabilized and anchored to the pilot nozzle by recirculating portions of the flame and its constituents from the furnace interior back towards the nozzle by protecting the air passing through the primary ignition zone from being directly affected by air flowing through the main combustion air conduit, diverging the fuel jets relative to the axial direction by an angle between about 20° to 80°, and giving the fuel jets a tangential directional component relative to the axial direction to spin the flame about the axis of the pilot. | 2009-03-12 |
20090068602 | Cigarette Lighter with Refractive Fuel Window - The exemplary embodiment is a reservoir for use with a cigarette lighter has a chamber for containing gas and liquid fuel and a lens made of a transparent material and having an internal surface adjacent the chamber. The internal surface allows optical transmission of visible light into and from the liquid fuel when in contact therewith, but denies the transmission of light into the gas when in contact therewith. The internal surface is contoured such that the transmissions are facilitated by optical refraction, and the denial is facilitated by optical reflection. The transmissions facilitate comparisons of the relative amounts of the liquid fuel and the gas in the chamber. The chamber has within a non-transparent object viewable through the lens during the transmissions and non-viewable through the lens during the denial. The object is a planar panel disposed substantially parallel to and displaced from the internal surface. Indicia proximate the lens may be provided for facilitating the comparison of the relative amounts of the liquid fuel and the gas in the chamber. The reservoir may be removable from the lighter for replacement and the lens may be viewable through a window in the lighter's housing. | 2009-03-12 |
20090068603 | Cigarette Lighter with Replaceable Fuel Cartridge - A cigarette lighter has a fuel cartridge for use therewith that may be removable there-from. In the exemplary embodiment, the fuel cartridge has a reservoir for holding a flammable liquid fuel, and includes a valve having a closed state for denying escape of the fuel from the reservoir and an open state for allowing such escape. The lighter has an ignition actuator for causing ignition of the escaped fuel when the ignition actuator is actuated, a nozzle for causing the ignited fuel to form a lighting flame, and a valve actuator cooperating with the ignition actuator to open the valve as the ignition actuator is actuated. In the exemplary embodiment, the reservoir has a transparent portion and the lighter housing is an opaque shell surrounding the reservoir with a viewing window there-through. The viewing window is aligned with the transparent portion of the reservoir to allow external observation of the amount of fuel within said chamber. The transparent portion includes indicia for gauging the amount of fuel in the reservoir during the external observation. The indicia are aligned with the window for gauging the amount of fuel in said reservoir during the external observation, and are structurally contoured to provide means for engaging the reservoir to force the reservoir from the lighter. | 2009-03-12 |
20090068604 | Cigarette Lighter with Replaceable Cartridge - A cigarette lighter has a fuel cartridge for use therewith that may be removable there-from. In the exemplary embodiment, the fuel cartridge has a reservoir for holding a flammable liquid fuel, and includes a valve having a closed state for denying escape of the fuel from the reservoir and an open state for allowing such escape. The lighter has an ignition actuator for causing ignition of the escaped fuel when the ignition actuator is actuated, a nozzle for causing the ignited fuel to form a lighting flame, and a valve actuator cooperating with the ignition actuator to open the valve as the ignition actuator is actuated. In the exemplary embodiment, the reservoir has a transparent portion and the lighter housing is an opaque shell surrounding the reservoir with a viewing window there-through. The viewing window is aligned with the transparent portion of the reservoir to allow external observation of the amount of fuel within said chamber. The transparent portion includes indicia for gauging the amount of fuel in the reservoir during the external observation. | 2009-03-12 |
20090068605 | QUARTZ GLASS MADE BURNER - A quartz glass burner including a multibranched-tube quartz glass nozzle made up of multiple tubules housed in a quartz glass outer tube, wherein an inner diameter of the outer tube contracted such that an inner diameter of a tip of the outer tube is between 0.65 and 0.90 times the inner diameter of a trunk of the outer tube. The nozzle is structured such that the region from the tubule branching portion to the tip thereof is housed in the outer tube. The outer tube housing the tubules has a length that is greater than or equal to 1.5 times the inner diameter of the tip of the outer tube. Therefore, there is provided a quartz glass burner that causes the flow velocity distribution of gas emitted from outer tube to be uniform at the tip of the burner, thereby enhancing glass microparticle deposition efficiency and also enhancing firepower during flame working. | 2009-03-12 |
20090068606 | HAND-HELD GAS COMBUSTION APPARATUS - The present invention relates to a hand-held gas combustion apparatus, comprises a gas storing tank, a gas discharging device, a housing, an ignition system and a flame device. The flame nozzle of the flame device and the metal sleeve tube are respectively in contact with the conductive wire and the electricity-guiding wire of the ignition system, so a static electricity spark is generated between the inner folding edge of the metal sleeve tube and the flame nozzle, so mixed combustion gas ejected from the flame nozzle is ignited, a gas combustion apparatus is therefore obtained, and the electricity-guiding wire is provided between the metal sleeve tube and the ignition system so the high-voltage static electricity can be guided back to the ignition system for forming a circuit. The present invention has overcome the disadvantages that a conductive wire of a conventional ignition system has to be provided at one side of the flame nozzle and the inconvenience of circuit design, and in the present invention there is no need of providing additional supporting racks for receiving and positioning the ignition system and the flame device | 2009-03-12 |
20090068607 | OUTDOOR CANDLES - A candle device having an outer container and a container lid is disclosed, Briefly described, in one embodiment, the outer container has a generally hollow interior, and the candle device also includes a candle pan that is supported in the interior of the outer container above a bottom surface of the outer container. In an upper region of the outer container, an opening having a size and shape is defined. The candle lid is sized and shaped to be complementarily received by the opening. | 2009-03-12 |
20090068608 | Torch with operating device - A torch includes a tank adapted to contain a fuel, a firebowl atop the tank defining a fill opening, and an operating device that fits over the firebowl as a snuffer. A closing device may be fitted into the fill opening. The closing device may be movable between a lowered closed position and a raised open position. The closing device defines at least one recess for receiving a portion of an operating device that moves the closing device between the open and closed positions. | 2009-03-12 |
20090068609 | Burner Arrangement - A burner arrangement is disclosed with a conical swirler in the form of a double cone which is arranged concentric to a burner axis and which encloses a swirl chamber, and with a central fuel lance which lies in the burner axis and projects from the cone point of the swirler into the swirl chamber, wherein a first stage is provided for injecting premix fuel, in which the premix fuel is injected radially outwards into the swirl chamber through injection openings which are arranged on the fuel lance, and wherein a second stage is provided for injecting premix fuel, in which the premix fuel is injected into an air flow, which is guided in the double cone, through injection openings in the double cone. With such a burner arrangement, the gas pressure which is required in the first stage is reduced by the entire premix fuel being injected into the swirl chamber in the first stage through two oppositely-disposed injection openings with increased opening diameter. | 2009-03-12 |
20090068610 | DENTAL BRACKETS OR ATTACHMENTS AND METHODS AND DEVICES FOR USING THE SAME - A method of attaching an orthodontic attachment to a patient's tooth with a photo-sensitive adhesive includes placing the attachment with a photosensitive adhesive applied thereto against a surface of the patient's tooth with the photosensitive adhesive in contact with the tooth and transmitting light through a solid, transparent portion of the appliance to initiate curing of the photo-sensitive adhesive to adhere the attachment to the tooth. | 2009-03-12 |
20090068611 | Orthodontic elastic apparatus - Apparatus for applying orthodontic elastics to brackets, including a container having a tube shaped member for housing said elastics in a predetermined position and/or orientation, said external side of the tube-shaped member carrying thereon a plurality of elastics, a release mechanism for selectively releasing an elastic from the container to an elastic placer positioned relative to said elastic housing to receive an elastic from said elastic container, said elastic placer having at least two rods sliding in use along said internal side of the tube-shaped member, said rods causing a first automatic inward-converging movement of the extremities of said rods respect said tube-shaped member in order to automatically receive an elastic from said elastic container, a second automatic outward-diverging movement of the extremities of said rods in order to automatically expand and apply said elastic directly to a bracket. | 2009-03-12 |
20090068612 | TOOTH POSITIONERS, METHOD OF MAKING THE SAME, AND METHOD OF POSITIONING TEETH USING THE SAME - A method for forming a tooth positioner for repositioning at least one tooth of a patient includes providing a dental arch cast of a patient, separating at least one tooth from the dental arch cast, fixing a pin in a stump part of the at least one separated tooth, and in any non-separated teeth, reconstructing the dental arch cast of the patient by aligning the separated teeth to correspond to the alignment in the patient's mouth and holding the pins in a material that may be softened by heat, heating an area to soften an area, applying force to the pin fixed in the at least one tooth to be repositioned to move it in a desired direction to obtain a realigned arch, and forming a tooth positioner corresponding to the realigned arch. The tooth positioner is used by having the patient wear it for a period of time. | 2009-03-12 |
20090068613 | PORTABLE COLOR CORRECTED OVER HEAD DENTAL LIGHT TO MATCH SHADES OF TEETH WITH TRUE CHROMATIC EFFICIENCY AND TO ACCELERATE TOOTH WHITENING - A portable color corrected light for the correct matching of tooth shades and acceleration of tooth whitening has been developed. In order to accurately match the tint and hue (true color) of teeth, the device provides 5500 to 6500 Kelvin, ambient-independent light with the ability to block or overwhelm ambient light to get a precise “color” reading of that tooth. The same light can accelerate the tooth whitening process with the addition of photo-accelerators to increase the decomposition of H | 2009-03-12 |
20090068614 | Dental polishing article which contains spherical resin particles - The present invention provides a dental polishing article having excellent polishability, which can polish dental composite resin, porcelain, dental restorative and prosthetic materials and teeth at a low cost, conveniently in a short time. More specifically, the present invention provides a dental polishing article which comprises a polishing portion formed by compounding polishing grains in an elastomer binder, and the polishing portion further comprising spherical resin particles. | 2009-03-12 |
20090068615 | Method of denture fixation - This method provides easy to use, non-irritating, comfortable, light, and reliable denture fixation that accurately copies the contours of the patient's gum line and holds dentures for 25-30 days. | 2009-03-12 |
20090068616 | Method And Apparatus For Making Products By Sintering And/Or Melting - The invention relates to a method for making metallic and/or non-metallic products | 2009-03-12 |
20090068617 | Method Of Designing Dental Devices Using Four-Dimensional Data - The present invention provides methods for acquiring and utilizing time-based 3d jaw motion images (4d datasets) to enhance the computer-aided design (CAD) of dental devices, which may include dental restorations, oral prostheses, and oral appliances. These 4d datasets may be used directly to provide a jaw motion model suitable for enhanced CAD or, they may be used to derive mathematical expressions that are then used to drive a motion simulation. The methods of the invention are based on acquiring time-based 3d images (a 4d sequence) of the upper and lower teeth, with each 3d frame in the time sequence capturing some upper and lower arch anatomy (the oral anatomy). Each image in the 4d sequence may therefore contain an accurate record of the relationship between the upper and lower arch in three dimensions. | 2009-03-12 |
20090068618 | METHOD AND DEVICE FOR DETERMINING THE CENTRIC POSITION OF HUMAN TEETH - The invention concerns methods and a device for the determination of the centric position of a human set of teeth with improved precision. This is needed for the adjustment of an articulator in the production of dentures. For this purpose a plurality of successive bite movements or displacement movements of the lower jaw are recorded in form of electronic signal data and evaluated for the determination of the centric position. | 2009-03-12 |
20090068619 | COMPOSITION CONTAINING AZIRIDINO GROUPS AND USE THEREOF - The invention relates to a composition comprising a prepolymer as component (A), wherein the prepolymer comprises aziridino groups and is characterized by an equivalent weight EW1, a crosslinker as component (B), wherein the crosslinker has a structure being different from the structure of the prepolymer and comprises aziridino groups and is characterized by an equivalent weight EW2, an initiator as component (C) being able to start curing of the composition, optionally filler(s) as component (D) and optionally additive(s) as component (E), wherein equivalent weight is defined as (molecular mass of the molecule)/(number of aziridino groups present in the molecule) and wherein EW1>EW2. The invention also relates to the use of the composition for coating, sealing, moulding, adhering, making impressions, producing a dental material. | 2009-03-12 |
20090068620 | System and method for the contactless determination and measurement of a spatial position and/or a spatial orientation of bodies, method for the calibration and testing , in particular, medical tools as well as patterns or structures on, in particular, medical tools - In order to develop known tracking systems, in particular in the medical field, the invention proposes a device for the contactless determination and measurement of a spatial position and/or spatial orientation of bodies using a tracking system, by means of which the bodies are located and brought into relation with one another, the tracking system, or at least components or modules thereof, being mobile. | 2009-03-12 |
20090068621 | PAPER CUTTING ACTIVITY KIT - An activity kit including an assembly sheet with a drawing provided thereon and a strip of color paper. The kit further includes instructions instructing a user to cut the strip of color paper into smaller pieces and adhere the cut pieces onto the drawing. | 2009-03-12 |
20090068622 | LETTER GUIDE SHEET - A drawing sheet assembly including a plurality of drawing sheets, each drawing sheet including sequential instruction indicia. The instruction indicia instructs a user to draw at least part of two pre-writing shapes that cooperate to create a rudimentary drawing. Each drawing sheet further includes a drawing space providing a space in which a user can draw the rudimentary drawing in accordance with the sequential instruction indicia. The plurality of drawing sheets collectively include instruction indicia instructing a user to draw at least part of all nine pre-writing shapes. | 2009-03-12 |
20090068623 | Method to determine that a person possesses analysis and synthesis skills - A method for demonstrating a person has strong analytic and synthetic ability. The subject is presented with a carefully chosen puzzle or problem, which is fairly easy to solve using trial and error, but which also can be solve by using analysis and synthesis. The subject is instructed to solve the puzzle without using trial and error and to describe or document their method. Where the subject successfully describes the steps such that they follow a logical flow and lead correctly to the solution, the subject has demonstrated analytic and synthetic ability in a verifiable way. | 2009-03-12 |
20090068624 | LETTER DEVELOPMENT CARDS - A card set including a plurality of letter or number development cards. Each card includes opposed instruction and challenge sides. Each instruction side has instruction indicia relating to the writing of a particular letter or number associated with the card. Each challenge side has visual indicia which indirectly identifies the particular letter or number and cues the user to write the particular letter or number. The challenge side of the card lacks any indicia that directly identifies which particular letter or number is associated with the card. | 2009-03-12 |
20090068625 | ALPHIE: an algorithmic system and method for teaching and learning writing and reading - This invention is an integrated alphabetic language teaching system that facilitates teaching multiple levels of the arts of writing and reading to individuals aged one year and older. | 2009-03-12 |
20090068626 | NUMBER WRITING DEVELOPMENT GUIDE - A number writing development guide including a number guide sheet having sequential instruction indicia. The sequential instruction indicia includes discrete ordered steps that cue a user in proper writing strokes to write an associated number. At least one of the discrete ordered steps relates to a common childhood activity or experience to thereby form an association between the activity or experience and the sequential instruction indicia. The guide further includes a challenge sheet coupled to the number guide sheet and having number challenge indicia. The number challenge indicia cues the user to arrive at a numerical answer to the number challenge and write the numerical answer thereon. | 2009-03-12 |
20090068627 | MEDICAL PHYSIOLOGICAL SIMULATOR INCLUDING A CONDUCTIVE ELASTOMER LAYER - Conductive elastomeric circuits are used in various simulated physiological structures such as tissues and organs, enabling feedback to be provided indicating whether a simulated task is being performed correctly. For example, a surgical trainer has a simulated human tissue structure made of an elastomeric composition, at least one reinforcing layer of a fibrous material, and at least one flexible electrical circuit. The surgical trainer preferably includes multiple areas for practicing surgical skills, each with evaluation circuits for providing feedback regarding that skill. Conductive elastomers are also incorporated into other types of medical training simulators, to similarly provide feedback. In another embodiment, a simulated organ has a conductive elastomeric circuit in the periphery of the simulated organ, enabling feedback to be provided to evaluate whether a person is properly manipulating the organ in response to a manual applied pressure. | 2009-03-12 |
20090068628 | Apparatus and Method for Cyber Healthcare Monitoring, With Calibration Using Thin Client Communicating Techniques - A moving part with fluid detection therein. e.g., a body.
| 2009-03-12 |
20090068629 | DUAL OUTPUT GRADEBOOK WITH RUBRICS - A system and method for assessing a student's performance in a course in an online course environment, the method comprising creating rubrics that correlate with course materials for an online course, the rubrics including a scoring schema which is stored in an educational management system, distributing the rubrics from the educational system to a user's computer through a network connection, displaying the rubrics on the user's computer together with their correlating course materials, recording the outcome of a student's performance on the rubrics, the outcome including a grade associated with a student, and transferring the recorded outcome to the educational management system. | 2009-03-12 |
20090068630 | SELF-ADJUSTING VENTILATION OUTLET WITH MULTIPLE FLOW RATES - This invention is for a ventilation outlet ( | 2009-03-12 |
20090068631 | Web based educational system for collaborative learning - A method and apparatus is disclosed for facilitating collaborative learning in an educational community via a web based educational system. In one embodiment, the method allows one or more of the educational participants to generate educational content, upload it to a document depository and teach it to other participants with the help of web based tools like web-conferencing, audio and video streaming, and web logging (blogging). The method also safeguards the quality of the generated educational content, by defining the role of the educational moderator and the access privileges that each class of participants has in using the web system's resources. | 2009-03-12 |
20090068632 | Mountable writing assembly - A mountable writing assembly includes a cover member, a visually transparent writing member, a replaceable sheet for displaying personalized information or images, and a backing member removably retained in the cover member. A method of allowing a user to create a customized dry-erase board is also disclosed. | 2009-03-12 |
20090068633 | Hygiene training device and method - A training device for nasal hygiene comprises a facial tissue sheet; where the facial tissue sheet has a first side, and where the facial tissue sheet also has a second side having an opposing planar relationship to the first side. A first-side tissue graphic is visible on the first side of the facial tissue sheet. The first-side tissue graphic comprises a permanent graphic and/or an active graphic. In addition, the first-side tissue graphic is a training mark. | 2009-03-12 |
20090068634 | SUBSTRATES AND INTERNAL STANDARDS FOR MASS SPECTROMETRY DETECTION - An inventive substrate is provided which includes a substrate compound of formula A-B | 2009-03-12 |
20090068635 | INDIRECTLY LABELLED ASSAY CONJUGATES AND METHODS OF PREPARING AND USING SAME - Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding member. The indirectly labelled assay conjugates demonstrate an increased sensitivity when employed in diagnostic assays compared to assay conjugates prepared by methods that do not include a step of submitting the binding member to denaturing conditions prior to labelling. Processes for the preparation of the indirectly labelled assay conjugates, methods of detecting an analyte comprising the use of the indirectly labelled assay conjugate and kits comprising the indirectly labelled conjugates are also provided. | 2009-03-12 |
20090068636 | VIRAL PROTEIN - The present invention is directed to an isolated polypeptide containing SEQ ID NO: 1 or an immunogenic fragment thereof. Also disclosed is an isolated nucleic acid encoding the polypeptide or containing a sequence at least 70% identical to SEQ ID NO: 3. Within the scope of this invention are related expression vectors, host cells, and antibodies. Also disclosed are methods of producing the polypeptide, diagnosing coronavirus infection, and identifying a test compound for treating coronavirus infection. | 2009-03-12 |
20090068637 | MONOCLONAL ANTIBODIES BINDING TO AVIAN INFLUENZA VIRUS SUBTYPE H5 HAEMAGGLUTININ AND USE THEREOF - The present application provides monoclonal antibodies that specifically bind to the hemagglutinin of avian influenza virus subtype H5, as well as monoclonal antibodies capable of blocking at least 50% of the hemagglutinin binding activity of these monoclonal antibodies. Such antibodies are useful, for example, in the detection, diagnosis, prevention, and treatment of avian influenza virus. Also provided herein are hybridoma cell lines, isolated nucleic acid molecules, and short peptides related to the monoclonal antibodies provided herein, and pharmaceutical compositions and kits containing the monoclonal antibodies provided herein. | 2009-03-12 |
20090068638 | PHAGE-BASED METHOD FOR THE DETECTION OF BACTERIA - The present invention relates to the field of biosensors useful for detecting bacteria. More particularly, the present invention relates to an electrochemical cell or biosensor and its use in a phage-based method and kit for the detection of bacteria. | 2009-03-12 |
20090068639 | System and method of quantitatively determining a biomolecule, system and method of detecting and separating a cell by flow cytometry, and fluorescent silica particles for use in the same, and kit comprising plural kinds of the silica particles in combination - A system of quantitatively determining a biomolecule, which has: allowing fluorescent silica particles capable of emitting fluorescence detectable by a flow cytometer to capture a target biomolecule fluorescent-labelled for quantitative determination; detecting the fluorescence emitted from the fluorescent silica particles themselves by using the flow cytometer; and measuring the intensity of the fluorescence of the labelled target biomolecule, thereby quantitatively determining the target biomolecule. | 2009-03-12 |
20090068640 | METHODS FOR DETECTING AND INACTIVATING A PRION - A method for the isolation or detection of a prion in a sample is disclosed. Also disclosed are methods for the disinfection and/or decontamination and/or inactivation of TSE infectivity. | 2009-03-12 |
20090068641 | Highly conserved genes and their use to generate probes and primers for detection of microorganisms - Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to generate species-specific, genus-specific, family-specific, group-specific and universal nucleic acid probes and amplification primers to rapidly detect and identify algal, archaeal, bacterial, fungal and parasitical pathogens from clinical specimens for diagnosis. The detection of associated antimicrobial agents resistance and toxin genes are also under the scope of the present invention. | 2009-03-12 |
20090068642 | Composition and pharmacology of novel alpha6-containing nicotinic acetylcholine receptors - Nicotinic acetylcholine receptors (nAChRs) comprising the α6 receptor subunit; nucleic acids, including vectors, comprising subunit incoding sequences; cells expressing the nAChRs of the invention; and methods of screening compounds are provided. | 2009-03-12 |
20090068643 | Dual Function Primers for Amplifying DNA and Methods of Use - The present invention provides novel nucleotide compositions that enable the detection of DNA synthesis products and methods for use thereof. In one embodiment, the method can be used in PCR and allows the progress of the reaction to be monitored as it occurs. In one embodiment, the invention employs at least one fluorescence-quenched oligonucleotide that can prime DNA extension reactions. In a second embodiment, the invention employs at least one fluorescence-quenched oligonucleotide that can function as a template for DNA extension reactions. In both embodiments, the oligonucleotide also functions as a probe for detecting the progress of successive extension reaction cycles. Signal detection is dependent upon DNA synthesis and can occur with or without probe cleavage. | 2009-03-12 |
20090068644 | METHOD FOR PRODUCING HIGHLY SENSITIVE ENDONUCLEASES, NOVEL PREPARATIONS OF ENDONUCLEASES AND USES THEREOF - The present invention pertains to methods for producing recombinant endonucleases having a high sensitivity, as well as to endonucleases preparations obtained by said methods, and uses thereof, especially for the detection of mismatches. | 2009-03-12 |
20090068645 | Labeling and Sequencing of Nucleic Acids - The invention provides for methods of end labelling a ds DNA molecule with a bar-code as well as adaptor mediated methodology for creating single stranded overhanging ends, lengthening single stranded overhanging ends, controlled size reduction of labelled ds DNA molecules, and adaptor mediated sequencing. Also disclosed are methods for parallel sequencing of multiple ds DNA molecules in a mixture by visual means. | 2009-03-12 |
20090068646 | METHODS AND KITS FOR DETECTING MUTATIONS - Disclosed are methods and kits for detecting mutations in DNA by comparing the size of an amplified microsatellite locus to the expected size. The methods and kits may used in various applications, including monitoring exposure of a cell or organism to a mutagen, evaluating the mutagenicity of an agent, and evaluating a putative precancerous or cancerous cell or tumor cell for microsatellite instability. | 2009-03-12 |
20090068647 | Dna sequences for the detection of and differentiation amongst pathogenic e.coli - Oligonucleotide sequences and methods for specifically detecting and differentiating amongst pathogenic | 2009-03-12 |
20090068648 | Method and system for determining a quality metric for comparative genomic hybridization experimental results - Various embodiments of the present invention determine various quality metrics that reflect the quality of two or more identically-executed or similar array-based comparative-genomic-hybridization (“aCGH”) experiments. In certain embodiments of the present invention, a pairwise quality metric is generated for each possible pair of aCGH experimental results within a set of aCGH experimental results. The pairwise quality metrics may be summed and optionally normalized to produce an overall quality metric for the set of aCGH experimental results. Various pairwise quality metrics can be used in different embodiments of the present invention, including pairwise quality metrics based on measures of aberration overlap. | 2009-03-12 |
20090068649 | Methods of DNA Methylation Detection - The present invention provides for methods of DNA methylation detection. The present invention provides for methods of generating and detecting specific electronic signals that report the methylation status of targeted DNA molecules in biological samples. | 2009-03-12 |
20090068650 | Metabolic Primers for the Detection of (Per) Chlorate-Reducing Bacteria and Methods of Use Thereof - The present invention is directed to metabolic primers for the detection of (per)chlorate-reducing bacteria and methods and compositions for use of the same in environmental bioremediation. | 2009-03-12 |
20090068651 | Method for the detection of the antibiotic resistance spectrum of mycobacterium species - Method for the detection of the antibiotic resistance spectrum of | 2009-03-12 |
20090068652 | Method for identifying the sequence of one or more variant nucleotides in a nucleic acid molecule - The invention relates to methods for identifying the sequence of one or more variant nucleotides in a nucleic acid molecule. The method involves cleaving a double-stranded nucleic acid molecule containing a mismatch with a mismatch-specific endonuclease which cleaves on the 3′ side of the mismatch, and preserving the integrity of the variant nucleotide by ligating a double-stranded linker with a 3′-overhang to said variant nucleotide. Because the variant nucleotide is immediately adjacent to the linker, PCR and/or sequence-by-synthesis analysis can be readily carried out. | 2009-03-12 |
20090068653 | BIOCHEMICAL AND GENETIC ANALYSIS FOR PREDICTION OF BREAST CANCER RISK - The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of three selected genes, here associated with specific biochemical activities, to identify individuals with increased or decreased risk of breast cancer. Using such methods, it is possible to reallocate healthcare costs in cancer screening to patient subpopulations at increased cancer risk and to identify candidates for cancer prophylactic treatment. | 2009-03-12 |
20090068654 | ASSAY FOR IDENTIFYING COMPOUNDS WHICH AFFECT STABILITY OF MRNA - The present invention relates to an assay for the identification of biologically active compounds, in particular to a reporter gene assay for the identification of compounds, which have an effect on mRNA stability. More particularly, the present invention relates to a reporter gene expression system and cell lines comprising said expression system. The invention further relates to compounds which destabilise mRNA. | 2009-03-12 |
20090068655 | COMPOSITION AND METHOD FOR NUCLEIC ACID SEQUENCING - The present invention provides compositions and methods for detecting incorporation of a labeled nucleotide triphosphate onto the growing end of a primer nucleic acid molecule. The method is used, for example, to genotype and sequence a nucleic acid. In a preferred embodiment, the method described herein detects individual NTP molecules. | 2009-03-12 |
20090068656 | Methods of diagnosing osteoarthritis - A method of diagnosing osteoarthritis in a mammal is provided comprising the steps of obtaining a biological sample from the mammal; and quantifying in the sample the expression of at least one chondrocyte-specific gene or gene product, wherein a differential in expression of said gene or gene product in comparison with expression of said gene or gene product in a non-osteoarthritic mammal is indicative of osteoarthritis. | 2009-03-12 |
20090068657 | METHOD OF PREDICTING THE CLINICAL RESPONSE TO CISPLATIN OR CARBOPLATIN CHEMOTHERAPEUTIC TREATMENT - Method for predicting the survival of a patient suffering from NSCLC to a cisplatin or carboplatin based chemotherapy treatment which comprises the step of determining the methylation state of a nucleic acid encoding 14-3-3 sigma in a biological sample from the patient, wherein the presence of methylation is indicative of longer survival of said patient as a response to said chemotherapy treatment. The methylation status of the 14-3-3 sigma gene can be easily determined in a serum sample. | 2009-03-12 |
20090068658 | Soybean mutant strain and soybean oil therefrom - A soybean oil of a decreased content of polyunsaturated fatty acids is produced by hybridizing, selecting and raising a soybean mutant KK21 characterized by a gene having a sequence of base given by the sequence No. 1 of the sequence listing, a soybean mutant M23 characterized by deletion of a gene having a sequence of base given by the sequence No. 2 of the sequence listing, a soybean mutant M24 characterized by a gene having a sequence of base given by the sequence No. 3 of the sequence listing, a soybean mutant M5 characterized by a gene having a sequence of base given by the sequence No. 4 of the sequence listing, a soybean mutant J18 characterized by deletion of a gene having a sequence of base given by the sequence No. 5 of the sequence listing, and one or two kinds or more of these soybean mutants. | 2009-03-12 |
20090068659 | Method for identifying the sequence of one or more variant nucleotides in a nucleic acid molecule - The invention relates to methods for identifying the sequence of one or more variant nucleotides in nucleic acid molecules. The method involves cleaving a double-stranded nucleic acid molecule containing a mismatch with a mismatch-specific endonuclease which cleaves on the 3′ side of the mismatch, and preserving the integrity of the variant nucleotide by ligating a Double-Stranded Linker with a degenerate 3′-overhang to said variant nucleotide. Because the variant nucleotide is immediately adjacent to the linker, PCR and/or sequence-by-synthesis analysis can be readily carried out. | 2009-03-12 |
20090068660 | USE OF METHYLATED OR UNMETHYLATED LINE-1 DNA AS A CANCER MARKER - The invention relates to a method of detecting LINE-1 (long interspersed nucleotide elements-1) DNA either methylated or unmethylated at the promoter region in a tissue or body fluid sample from a subject. Also disclosed are methods of using LINE-1 DNA as a biomarker for diagnosing, predicting, and monitoring cancer progression and treatment. | 2009-03-12 |
20090068661 | PROBE, PROBE SET, PROBE CARRIER, AND TESTING METHOD - A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 4 and mutated sequences thereof. | 2009-03-12 |
20090068662 | METHOD AND TEST KIT FOR THE SEPARATION, PURIFICATION AND RECYCLING OF LONG- AND SHORT-CHAIN NUCLEIC ACIDS - Long- and/or short-chain nucleic acids are separated, purified and recovered by binding the nucleic acid to a solid phase using a binding buffer, to obtain a bonded nucleic acid, and eluting of the bonded nucleic acid from the solid phase, wherein the binding buffer comprises at least one citric acid salt and at least one alcohol. | 2009-03-12 |
20090068663 | SCREENING METHODS AND SEQUENCES RELATING THERETO - A screening method for identifying an individual having a pre-disposition towards having a cancer is disclosed, which screening method comprises the steps of:
| 2009-03-12 |
20090068664 | AMPLIFICATION METHODS AND COMPOSITIONS - The present invention provides methods and routines for developing and optimizing nucleic acid detection assays for use in basic research, clinical research, and for the development of clinical detection assays. In particular, the present invention provides methods for designing oligonucleotide primers to be used in multiplex amplification reactions. The present invention also provides methods to optimize multiplex amplification reactions. | 2009-03-12 |
20090068665 | METHODS AND KITS FOR IDENTIFYING TARGET NUCLEOTIDES IN MIXED POPULATIONS - Ligation-based methods and kits are disclosed for identifying at least two target nucleotides in a mixed population sample that is a sample that contains or potentially contains target nucleic acid sequences from more than one source. Typically, two ligation reaction compositions are formed ligation products generated, and the ligation products or their surrogates are analyzed to identify target nucleotides in the mixed population sample. In certain embodiments, the target nucleic acid sequences, the ligation products, or both are amplified. In certain embodiments, multiplex amplification and/or ligation reactions are performed. | 2009-03-12 |
20090068666 | Systems and Methods for Determining an Amount of Starting Reagent using the Polymerase Chain Reaction - Systems and methods for calculating an initial amount of target nucleic acid N | 2009-03-12 |
20090068667 | METHODS AND ASSAYS FOR SCREENING STEM CELLS - The present invention provides methods and assays for screening cells, such as stem cells, for chromosomal aberrations. In particular, the present invention provides a rapid, sensitive assay platform for detecting high and low levels of chromosomal aberrations present in a cell population. This includes, but is not limited to, detection of extra chromosomes (trisomies) as well as insertions of small segments that are undetectable using standard cytogenetic studies, wherein the abnormal cells comprise a low percentage of the total cell population. | 2009-03-12 |
20090068668 | Waveguide-Based Optical Scanning Systems - A scanning sensor system, methods of use and kits for detecting a biologically active analyte are provided. The scanning sensor system includes a light source, a detector, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, and at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector. | 2009-03-12 |
20090068669 | SLC9A3R1 DIRECTED DIAGNOSTICS FOR NEOPLASTIC DISEASE - Disclosed are methods for diagnosing cancer in a test cell sample or fluid sample by detecting an increase in the level of expression of SLC9A3R1 in the test cell sample or fluid sample as compared to the level of expression of SLC9A3R1 in a control cell sample or fluid sample isolated from a normal subject. | 2009-03-12 |
20090068670 | STRATIFIN DIRECTED DIAGNOSTICS FOR NEOPLASTIC DISEASE - Disclosed are methods for diagnosing cancer in a test cell sample or fluid sample by detecting an increase in the level of expression of stratifin in the test cell sample or fluid sample as compared to the level of expression of stratifin in a control cell sample or fluid sample isolated from a normal subject. | 2009-03-12 |
20090068671 | Binding method and apparatus for sorting objects - The present invention relates to a method and apparatus of sorting objects including, providing a sample having wanted objects and unwanted objects; coating a surface of a sample holder with an antibody; placing an eluted sample on the sample holder; binding an antigen in the wanted objects with the antibody on the surface of the sample holder to sort the objects into wanted objects and unwanted objects; separating the wanted objects; and performing PCR-based STR analysis on the wanted objects. In one embodiment, holographic optical trapping is used to further sort the wanted objects. In other embodiments, the wanted objects are sperm and the antibody is a human sperm specific antibody, and the PCR is single cell PCR-based STR analysis. In still other embodiments, the binding is direct or indirect, ligands are used to bind to object-specific organomolecules, and protein A or protein G are used to bind the antibody. | 2009-03-12 |
20090068672 | DETECTION SYSTEM - The use of a red nucleic acid stain, in particular red fluorescent SYTO® dye in various methods used for the detection or characterisation of nucleic acids is described. In particular, the red nucleic acid stains have been found to be particularly compatible with the polymerase chain reaction (PCR), and therefore form the basis of enhanced detection methods. | 2009-03-12 |
20090068673 | UTILIZATION OF COMPATIBLE SOLUTES TO IMPROVE THE PERFORMANCE OF THE TECHNIQUES USING IMMOBILIZED BIOLOGIC MATERIALS - This invention is based upon the application of compatible solutes to immobilized biological materials or to immobilize in order to improve the technical performance using the same, namely nucleic acid and proteins or biosensors micronets. The above mentioned compatible solutes are selected from a group that includes Mannosylglycerate (MG) and its 3 derivatives manno-sylglyceramide (MGA), -mannosylglycerol (MGOH), and mannosyl-lactate (MGLac), 1,1-di-glycerol phosphate (DGP), ectoin, hydroxyectoin, and or derivatives or combinations thereof. The improved performance of the above mentioned techniques might be due to: a better state of preservation of the material to be immobilized, increasing the life expectancy of the material, and/or decreasing the storage and/or transport requirements, a more efficient and uniform deposition of the material on the support, more efficiency and/or specificity of hybridation of the marked material, all this originating an increase of the signal-to-noise ratio. | 2009-03-12 |
20090068674 | Method and device for preparing a sample of biological origin in order to determine at least one constituent contained therein - The invention relates to a method of preparing an original sample ( | 2009-03-12 |
20090068675 | Methods for improved diagnosis of dysplasias - The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterising the proliferation properties of the respective cell. The characterisation of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens. | 2009-03-12 |
20090068676 | Diagnostic methods for congestive heart failure - The invention provides an assay for the quantification of circulating glycophorin in biological fluid samples. The circulating glycophorin measured by this assay is a truncated glycophorin diagnostic for congestive heart failure (CHF). | 2009-03-12 |
20090068677 | BIOMARKER FOR DIAGNOSING HEART DISEASE AND THE USE THEREOF - The invention relates to the following methods [1] to [3] and to a kit for carrying out the methods: | 2009-03-12 |
20090068678 | Method for identifying modulators of NOAH10 useful for treating Alzheimer's disease - Methods for identifying modulators of NOAH10 are described. The methods are particularly useful for identifying analytes that antagonize NOAH10's effect on processing of amyloid precursor protein (APP) to amyloid beta (Aβ) peptide and are useful for identifying analytes that can be used for treating Alzheimer disease. | 2009-03-12 |
20090068679 | Binding partners of the placental growth factor, especially antibodies directed against the placental growth factor, and production and use thereof - The invention relates to binding partners of the placental growth factor (or placenta growth factor, PIGF), especially antibodies directed against the placental growth factor, and production and use thereof. | 2009-03-12 |
20090068680 | Method for Characterizing Immune Disorders - Methods for characterizing immune diseases are provided which include exposing a sample of biological fluid from a patient to a pooled population of particles, wherein a first subset of particles is bound to a reactant that binds an antibody and a second subset of particles is bound to a reactant that binds an antigen. The methods further include determining a ratio of measured amounts of the antibody and the antigen in the sample. In some cases, the ratio is compared to one or more standard ratios representing differing states of the disease to determine a state of the disease within the patient. In other embodiments, the steps of exposing and determining a ratio of antibody to antigen are repeated for one or more additional samples of biological fluid taken from the patient. In such cases, at least two ratios are compared to analyze a progression of the disease. | 2009-03-12 |
20090068681 | METHODS AND COMPOSITIONS FOR RISK STRATIFICATION - The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations. | 2009-03-12 |
20090068682 | IMMUNOLOGICAL ASSAY FOR PLASMIN-DIGESTED PRODUCTS OF STABILIZED FIBRIN - A method of immunologically analyzing plasmin-digested products of stabilized fibrin, characterized by using a combination of a monoclonal antibody (a) which does not react with stabilized fibrin, fibrinogen, and plasmin-digested products of fibrinogen, but reacts with a neoantigen which is newly exposed in a D domain by digesting stabilized fibrin with plasmin, and a monoclonal antibody (b) which recognizes a site different from that recognized by the monoclonal antibody (a), and specifically reacts with plasmin-digested products of stabilized fibrin, wherein one of the monoclonal antibodies (a) and (b) is carried on a magnetic particle, and the other is labeled with an enzyme, and a chemiluminescent substrate is used as a substrate for the enzyme, is disclosed. | 2009-03-12 |
20090068683 | MARKERS FOR PREECLAMPSIA - This document provides methods and materials related to determining whether or not a pregnant mammal (e.g., a pregnant human) has preeclampsia. For example, methods and materials related to the use of urinary podocytes to determine whether or not a pregnant human has preeclampsia are provided. | 2009-03-12 |
20090068684 | Serine and threoninephosphorylation sites - The invention discloses 345 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above. | 2009-03-12 |
20090068685 | Method of Identifying Biomarkers in Human Serum Indicative of Pathologies of Human Lung Tissues - A method of identifying altered biomarker expression levels in a human serum specimen to diagnose asthma or non-small celled lung cancers in humans. The existence of asthma or non-small celled lung cancers in a patient can be determined by subjecting a blood sample from the patient to a simple blood test to determine the expression levels of certain specific biomarkers. The expression levels of the specific biomarkers are compared to ranges of expression levels for the same biomarkers which are indicative of individuals known to have asthma, non-small cell lung cancers, or neither. Comparing the expression levels will determine the existence or non-existence of asthma or non-small cell lung cancer. | 2009-03-12 |
20090068686 | Method for diagnosing auto-immune chronic urticaria - In certain embodiments, the present invention relates to methods, compositions, and kits for diagnosing autoimmune chronic urticaria. For example, in certain embodiments, such methods generally comprise detecting the presence of auto-antibodies to cell-surface IgE receptors or cell-bound IgE in a patient. Such auto-antibodies may be detected by (a) obtaining donor basophils and associated leukocytes from one or more donors, (b) challenging the donor basophils and associated leukocytes with control serum and quantifying the amount of histamine released by the donor basophils and associated leukocytes, (c) calculating a normalized baseline of histamine release, wherein the normalized baseline of histamine release represents a mean percentage of histamine released by the basophils and associated leukocytes of an individual donor plus a specified amount above such mean, (d) reacting patient serum with the donor basophils and associated leukocytes, (e) measuring the percentage of histamine released by the donor basophils and associated leukocytes in response to the patient serum, and (f) comparing the percentage of histamine released by the donor basophils and associated leukocytes in response to the patient serum to the normalized baseline of histamine release. | 2009-03-12 |
20090068687 | Screening platform for discovery of immunomodulatory activities in traditional medicine - The present invention relates to a method of screening traditional medicines for immunomodulating activity and anti-tumor activity. The method involves applying techniques and tools used in the field of proteomics, isolating an active ingredient from a natural ingredient historically used as a traditional medicine, stimulating splenocytes, and measuring and determining biomarker indicators resulting from such stimulation. | 2009-03-12 |
20090068688 | PVDF membranes - The invention provides a method of treating a polyvinyl difluoride (PVDF) membrane comprising: (a) contacting said membrane with an alcohol and a wetting agent; and (b) drying said membrane. | 2009-03-12 |
20090068689 | Molecular phenotyping of severe asthma - The present invention discloses a method for classifying individuals into those who have airway hyperreactvitiy and those with asthma based on cytokine expression patterns. It is contemplated that such a method will enable rapid identification of individuals requiring intensive treatment for asthma, thereby reducing morbidity and improving quality of life for those affected. | 2009-03-12 |
20090068690 | METHODS FOR IDENTIFYING PATIENTS WITH AN INCREASED LIKELIHOOD OF HAVING OVARIAN CANCER AND COMPOSITIONS THEREFOR - Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods may further comprise a two-step analysis. Biomarkers of interest include genes and proteins that are, for example, involved in defects in DNA replication/cell cycle control, cell growth and proliferation, escape from apoptosis, angiogenesis or lymphogenesis, or the mechanisms of cancer cell motility and invasion. In some aspects of the invention, expression of a biomarker is detected at the protein level using a biomarker-specific antibody or at the nucleic acid level using nucleic acid hybridization techniques. Methods for detecting ovarian cancer in patients are further disclosed herein. Kits for practicing the methods of the invention are further provided. | 2009-03-12 |