| 10th week of 2009 patent applcation highlights part 55 |
| Patent application number | Title | Published |
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| 20090061387 | MULTIPLE ROOT IMPLANT - A dental implant has a body and a plurality of distinct roots that extend outwardly from the main portion that generally define a coronal-apical axis. A porous tantalum metal portion is disposed at the body for engaging bone and the plurality of distinct roots are configured to resist a torsional force that is applied to the dental implant and around the coronal-apical axis. | 2009-03-05 |
| 20090061388 | DENTAL PROSTHETIC DEVICE WITH SOFT TISSUE BARRIER PROMOTION MATERIAL - A dental prosthetic device has a body with a soft tissue engagement region formed of porous metal and that defines pores for the ingrowth of soft tissue into the pores. In one form, the porous metal includes tantalum. The porous metal may be partially filled with a resorbable material. The body may have a coronal end portion with an esthetic material. | 2009-03-05 |
| 20090061389 | DENTAL IMPLANT PROSTHETIC DEVICE WITH IMPROVED OSSEOINTEGRATION AND SHAPE FOR RESISTING ROTATION - A dental implant has a body that generally defines a coronal-apical axis and a porous tantalum metal portion that is disposed at the body for engaging bone and having a non-circular outer periphery extending around the axis. The non-circular outer periphery is shaped to engage a bore in a bone to resist a torsional force that is applied to the dental implant and around the coronal-apical axis. | 2009-03-05 |
| 20090061390 | Method for making a dental restoration - A series of ceramic ingots is provided in which each ingot in the series, referred to as base ingots, has a shade corresponding to a different shade of a shade guide. The number of differently shaded base ingots is less than the total number of shades associated with the shade guide. A base ingot is selected from the series having a shade of a value at least as high as a shade associated with a patient's tooth. If the base ingot shade matches the patient's tooth, a restoration made with the selected base ingot can be glazed as is; otherwise the dental restoration is stained with a stain having a lower value than the selected base ingot to match the tooth. Thus, the total different number of ingot shades needed in inventory is reduced but without requiring staining in every case. | 2009-03-05 |
| 20090061391 | Method for Operating a Laser System and Laser System for Bleaching Teeth - In a method for operating a laser system for bleaching teeth, a water-containing bleaching agent applied onto teeth is heated by a laser beam, wherein the laser beam has a wavelength in a range of 2.6 μm, inclusive, to 3.1 μm, inclusive, or in a range of 9.0 μm, inclusive, to 11.0 μm, inclusive. The laser system is operated in pulse mode with individual pulses of the laser beam, wherein the individual pulses each have a fluence that is below a vaporization threshold fluence of the bleaching agent. | 2009-03-05 |
| 20090061392 | Early Detection of Damage to Units Used in the Oral Cavity - A unit to be arranged in the oral space, which unit can, in particular, be a diagnosis and/or therapeutic treatment device. If the external shell of a unit of this type gets damaged, there is a risk of parts of the external shell detaching or of harmful substances leaking from the interior of the unit. In order to detect damage of this type as early as possible, the unit is provided with an indicator substance that is enclosed within the external shell and can be detected outside of the external shell in case the external shell breaks. The use of edible bitter substances for detecting damage on diagnostic and/or therapeutic units used in the oral spaces as well as to the use of edible dyes for detecting damage on diagnostic and/or therapeutic units used in the oral space are also provided. The dye is provided on the interior of the corresponding unit to leak out in case the corresponding unit gets damaged. | 2009-03-05 |
| 20090061393 | RETRACTION OF SULCUS - The invention concerns a method of retraction of sulcus, in which, in a first step, a flowable retraction material ( | 2009-03-05 |
| 20090061394 | COLORING SHEET - A coloring sheet including a sheet of paper and a design formed on the sheet of paper. The design is at least partially formed by a pair of parallel, adjacent raised lines, wherein the adjacent raised lines are spaced apart by a distance of less than about ½ inch. | 2009-03-05 |
| 20090061395 | SEQUENCE DOT CONNECT SHEETS - A drawing sheet assembly including a drawing sheet and a plurality of dots printed on the sheet. The dots have a differing optical property relative to each other. The drawing sheet assembly further includes a sequence guide configured guide a user to connect the dots in a particular sequence such that when a user connects the plurality of dots in accordance with the sequence guide a drawing or part of a drawing is created. | 2009-03-05 |
| 20090061396 | Crochet Stitch/Pattern - The present invention relates to a new method for creating crocheted items using a classical crochet hook to form stitches in a new pattern. The pattern produces a visually very attractive surface (on both front and back side) and leads to a specific thickness and density of the produced items which makes them keep their shape very well. The new crocheting method can be applied to a variety of materials producing items especially in the fields of garments and home accessories. The present invention is described in one basic version and two variations. | 2009-03-05 |
| 20090061397 | Educational card game for enhancing counting skills - A method for playing a game, involving the steps of determining a combination number; dealing to at least one player at least three cards from a deck to make a hand, the deck having at least one group of cards sequentially numbered from one to thirteen; and providing a reward to the player for each combination the player makes of the cards equaling the combination number. A typical combination number is 10, or multiples of 10. | 2009-03-05 |
| 20090061398 | Language Teaching Method and Apparatus - A student is taught a language through the introduction of target expressions including features, such as specific words or phrases and language structure. The student is presented one or more reference expressions made up of target expression with one or more of its features altered, while maintaining semantic meaningfulness, and he is prompted with a prompting expression designed to elicit the target expression as a response, in view of the at least one reference expression. | 2009-03-05 |
| 20090061399 | EDUCATIONAL SOFTWARE WITH EMBEDDED SHELTERED INSTRUCTION - A system, method and a computer readable medium for providing virtual learning of academic topic unrelated to languages in a non-native language of a student. The system includes an input device, which receives user input, a datastore, which stores the academic topic. At least a portion of the academic topic is stored in both native and non-native languages. The system further includes a processor, which obtains the academic topic based on the user input and an output device, which outputs the academic topic provided by the processor to a user. The academic topic is obtained by the processor with sheltered instruction in the non-native language. Upon a user request, the continuous providing of the academic topic is paused and at least one key term of the academic topic is provided in the native language. | 2009-03-05 |
| 20090061400 | Unknown - The Ross Tutoring System (RTS) for reading is based on phonetic popularity. Its uniqueness comes from the grouping of sounds in a fashion that is easy for kids to learn by, and by various other methods detailed in my attached description. Along with these groupings of sounds are various support materials, including games, reading materials, and spelling sheets, all of which are described. These games, reading materials, and spelling sheets are unique as well, and provide support for this new, more effective way of teaching reading. Hands-on reading is also an essential part of my approach. | 2009-03-05 |
| 20090061401 | Apparatus to enhance enjoyment from reading printed subject matter - A handheld apparatus to enhance reading enjoyment of printed subject matter includes a housing member having a predetermined shape and a predetermined size. A micro-processing unit is disposed in the housing member. There is a power source disposed within the housing member. Such power source is connected to the micro-processing unit. A program containing at least a dictionary therein is disposed in the micro-processing unit. Additionally, there is a scanner disposed in the housing member that is in electrical communication with the power source and the micro-processing unit for scanning a printed word. Finally, there is a display screen disposed on a predetermined face of the housing member and in electrical communication with the power source and the micro-processing unit for displaying a definition of a scanned word. | 2009-03-05 |
| 20090061402 | Methods And Systems For Providing Interactive Educational Training - The present invention provides computer implemented and interactive educational platforms for training professionals, such as healthcare workers. In particular, the present invention provides learning modules for professionals for implementing an interactive curriculum that is designed to ensure thorough coverage of core and advanced competencies. | 2009-03-05 |
| 20090061403 | RATING METHOD AND SYSTEM FOR EARLY CHILDHOOD EDUCATIONAL PROGRAMS - The invention describes a method for evaluating educational programs which, firstly, develops criteria which will address the strengths and weaknesses of the educational program. The second step of the method is to observe the criteria, chosen in step one, in the educational program. The third step is to assign a numerical value to each of the criteria observed in step two. The next step is to assign an overall rating to the educational program based on the numerically valued criteria. The personnel involved in the educational program can then decide what steps in addition to the assessment can be done to improve or maintain the educational program. | 2009-03-05 |
| 20090061404 | MEDICAL TRAINING SIMULATOR INCLUDING CONTACT-LESS SENSORS - A medical training simulator includes contact-less sensors and corresponding detection objects, configured to enable sensor data collected during a training exercise to be used to evaluate the performance of the training exercise. The simulator includes a simulated anatomical structure, at least one contact-less sensor, and at least one detection object. During a training exercise, a spatial relationship between the contact-less sensor and the detection object produces data for evaluating performance of the training exercise. Either the contact-less sensor or the detection object is embedded in the simulated physiological structure, while the other is included in either a support for the simulated physiological structure, or as part of a tool used during the training exercise. Many types of contact-less sensors can be employed, including capacitance sensors, impedance sensors, inductive sensors, and magnetic sensors. | 2009-03-05 |
| 20090061405 | DOLL WITH REVOLVING ABDOMINAL CHAMBER TO SIMULATE PREGNANCY - An abdominal torso element for a doll incorporates a receiving cavity with a first rotational element mounted in the torso element having an enlarged abdominal surface representing a pregnant abdomen and incorporating an associated fetal cavity. The first rotational element is positionable in a first closed position with the enlarged abdominal surface exterior to the torso element simulating pregnancy and a second open position with the enlarged abdominal surface received in the receiving cavity. A second rotational element is nested within the first rotational element and has an outer surface representing a non-pregnant abdomen. The second rotational element is positionable in a first open position and a second closed position with the non-pregnant abdominal surface exposed simulating a non-pregnant condition. A fetus/baby model is removably received within the fetal cavity and can be viewed and removed/inserted with the first and second rotational elements in the open position. | 2009-03-05 |
| 20090061406 | CONSTRUCTING A PROFILE USING SELF-DESCRIPTIVE IMAGES FOR USE IN A SOCIAL ENVIRONMENT - Methods and apparatus are described in which a plurality of sensory stimuli are presented to a user. A response from the user to each of selected ones of the sensory stimuli is recorded where the response is given within a period of time from the presentation of the corresponding sensory stimulus. The period of time is selected to increase the likelihood that the recorded responses are spontaneous. | 2009-03-05 |
| 20090061407 | Adaptive Recall - The invention relates to a system and methods for determining user knowledge of information, calculating and employing “lag”, i.e., adaptive recall, time for delaying review and testing of the information depending on a user's progress, and/or selecting additional information to be reviewed and tested during the lag time. The present system and methods are adapted to be used in conjunction with conventional and novel computer systems and methods and provides adaptive recall therefor. | 2009-03-05 |
| 20090061408 | DEVICE AND METHOD FOR EVALUATING LEARNING - A device and method for evaluating learning including a level examining module, a course planning module and a course evaluation module are provided. The level examining module provides a level examination for a user to determine a current capability level of the user. The course planning module plans a learning course for the use according to the current capability level as determined by the level examining module. The course evaluation module generates an evaluation quiz according to the learning course. After the user finishes the evaluation quiz, the course evaluation module also generates learning information to evaluate the user's learning status. | 2009-03-05 |
| 20090061409 | DEVICE AND METHOD FOR ARRANGING LEARNING COURSES - A device and method is provided for a user to arrange learning courses. The device comprises: a course database, a capability examining module and a course arranging module. The course database stores multiple learning courses, each including multiple learning quizzes. The capability examining module provides capability examination(s) for the user to determine the user's current capability level. The course arranging module acquires the corresponding learning courses from the course database according to the capability level determined by the capability examining module, and arranges these acquired corresponding learning courses for the user to learn. | 2009-03-05 |
| 20090061410 | Multiloop Engineered Heart Muscle Tissue - The invention is directed to a method for the preparation of a multiring engineered heart tissue construct suitable for use in cardiac tissue augmentation and/or replacement therapy. The invention further refers to multiring EHT constructs which comprise at least two force-generating engineered heart tissue rings fused with each other and a device for preparing the same. Finally, the invention relates to force-generating engineered heart tissue rings derived from human cells and their use in drug screening and target validation assays. | 2009-03-05 |
| 20090061411 | ANALYSIS OF SULFATED POLYSACCHARIDES - The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described. | 2009-03-05 |
| 20090061412 | Methods for Detecting Papillomavirus DNA in Blood Plasma and Serum - This invention relates to the detection of extracellular papillomavirus DNA in blood plasma or serum from a human or animal. In particular, the invention relates to the detection, identification, evaluation, or monitoring of neoplastic, premalignant or malignant disease associated with a papillomavirus. The invention thereby provides methods for the identification of individuals at risk for, or having, cervical dysplasia, cervical intraepithelial neoplasia, or cervical cancer. | 2009-03-05 |
| 20090061413 | ISOTHERMAL SCREENING OF HIV-1 RELATED NUCLEIC ACIDS - The presently described technology relates generally to the art of molecular diagnostics and more particularly to point-of-care diagnostic methods and materials. The diagnostic methods and materials of the presently described technology are suitable for a variety of uses including but not limited to the bedside or field diagnosis of infectious or noninfectious diseases. | 2009-03-05 |
| 20090061414 | Method for quantification of recombinant viruses - Titration is an important and critical step in dosing recombinant virus for gene therapy. A relatively fast, convenient and sensitive method that allows for precise quantification of recombinant retrovirus is presented. The method is based on PCR amplification of a foreign gene by the PRINS (primer in situ DNA synthesis) technique. The PRINS technique is based on the sequence-specific annealing of unlabeled oligonucleotide DNA it situ. This oligonucleotide operates as a primer for in situ chain elongation catalyzed by the Taq I polymerase. Using -labeled nucleotides as a substrate for chain elongation, the neo-synthetic DNA is labeled by an FITC-conjugated anti-antibody. To avoid the possibility of false positives, the puromycin resistance gene, which is associated with the transgene in the same viral vector and is not normally present in mammalian cells was amplified. The retroviral titer was evaluated by counting FITC-positive cells after PRINS labeling, while knowing the number of cells that were transduced with different amounts of viral supernatant. A comparable viral concentration of 1×10 | 2009-03-05 |
| 20090061415 | Sequences Diagnostic For Shrimp Pathogens - Primers have been isolated that are diagnostic for the detection of the taura syndrome virus (TSV). The primers are based on a new portion of the TSV genome and may be used in primer directed amplification or nucleic acid hybridization assay methods. | 2009-03-05 |
| 20090061416 | Surfaces and methods for biosensor cellular assays - Disclosed is an apparatus for measuring ligand-induced cell activity as defined herein, the apparatus including: an optical biosensor having a contact surface including a compatibilizer zone, an optional surface modifier zone, and a live cell zone. The disclosure also provides a method of making the apparatus and methods for measuring ligand-induced live cell activity with the apparatus. | 2009-03-05 |
| 20090061417 | INFLUENZA A VIRUS DETECTION METHOD AND KIT THEREFORE - The invention provides oligonucleotides for a simple, specific and/or sensitive test for the presence of Influenza A. In particular, the present invention provides a primer(s), probe(s) and/or test(s) for Influenza A Subtype H5N1. Kits comprising probe(s) and/or primer(s) useful in the test are also provided. | 2009-03-05 |
| 20090061418 | DISPOSABLE ANALYTICAL MICROPROCESSOR DEVICE - The present invention generally relates to the determination of an analyte concentration (quantitative determination) or whether an analyte threshold level has been passed (qualitative determination) in a biological sample through employment of a disposable analytical microprocessor device. The device can include a batch-specific, self-executable algorithm for the calculation of the analyte concentration. | 2009-03-05 |
| 20090061419 | GENOMIC MARKERS OF HEPATITIS B VIRUS ASSOCIATED WITH HEPATOCELLULAR CARCINOMA - The present invention provides methods of predicting a pre-disposition of HBV-infected individuals to develop hepatacellular carcinoma (HCC). | 2009-03-05 |
| 20090061420 | MUTATIONAL PROFILES IN HIV-1 PROTEASE CORRELATED WITH PHENOTYPIC DRUG RESISTANCE - The present invention is directed to the field of nucleic acid diagnostics and the identification of base variation in target nucleic acid sequences. More particularly, the present invention relates to the use of such genotypic characterization of a target population of HIV and the subsequent association, i.e., correlation, of this information to phenotypic interpretation in order to correlate virus mutational profiles with drug resistance. The invention also relates to methods of utilizing the mutational profiles of the invention in drug development, i.e., drug discovery, drug design, drug modification, and therapy, treatment design, clinical management and diagnostic analysis | 2009-03-05 |
| 20090061421 | CRYSTAL STRUCTURE OF CMY-10, A BETA-LACTAMASE CAUSING ANTIBIOTIC RESISTANCE WITH EXTENDED-SUBSTRATE SPECTRUM - The present invention related to a method for crystallizing a CMY-10 being a β-lactamase with extended-substrate spectrum, a crystal of CMY-10, and a crystal structure of CMY-10. With utilization of three-dimensional structure of CMY-10 protein provided by the present invention, it is possible to develop novel antibiotics or inhibitors that can prevent an emergence of resistance bacteria appeared by plasmidic class C β-lactamases having extended-substrate specificity. | 2009-03-05 |
| 20090061422 | Diagnostic markers of breast cancer treatment and progression and methods of use thereof - To maximize both the life expectancy and quality of life of patients with operable breast cancer, it is important to predict adjuvant treatment outcome and likelihood of progression before treatment. The instant invention details the usage of a machine-learning based method to develop a cross-validated model to predict the outcome of adjuvant treatment, particularly chemotherapy treatment outcome, and likelihood of progression before treatment. The model includes standard clinicopathological features, as well as molecular markers collected using standard immunohistochemistry and fluorescence in situ hybridization. The model significantly outperformed the St. Gallen Consensus guidelines and the Nottingham Prognostic Index and has the potential to provide a clinically useful and cost-effective prognostic for breast cancer patients. | 2009-03-05 |
| 20090061423 | PHARMACOGENOMIC MARKERS FOR PROGNOSIS OF SOLID TUMORS - The present invention provides methods, systems and equipment for prognosis or evaluation of treatment of solid tumors. Gene markers that are prognostic of solid tumors can be identified according to the present invention. Each gene marker has altered expression patterns in PBMCs of solid tumor patients following initiation of an anti-cancer treatment, and the magnitudes of these alterations are correlated with clinical outcomes of these patients. In one embodiment, a Cox proportional hazards model is used to determine the correlations between clinical outcomes of RCC patients and gene expression changes in PBMCs of these patients during the course of a CCI-779 treatment. Non-limiting examples of genes identified by the Cox model are depicted in Tables 4A3 4B, 5 A and 5B. These genes can be used as surrogate markers for prognosis of RCC. They can also be used as pharmacogenomic indicators for the efficacy of CCI-779 or other anti-cancer drugs. | 2009-03-05 |
| 20090061424 | UNIVERSAL LIGATION ARRAY FOR ANALYZING GENE EXPRESSION OR GENOMIC VARIATIONS - The present invention provides an array system comprising a plurality of immobilized oligonucleotides comprising artificial sequences and a plurality of complementary ligation templates, as well as methods and kits for using the array system to analyze populations of nucleic acids. In particular, target nucleic acids are ligated to the immobilized oligonucleotides on the array in the presence of the complementary ligation templates. | 2009-03-05 |
| 20090061425 | Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences - Disclosed herein are methods and kits for selectively amplifying, detecting or quantifying a DNA fragment with a specific end sequence, especially generated following restriction enzyme digestion. This method can be used, for example, to detect a hypomethylated DNA fragment. This methods and kits are especially useful in detecting or quantifying a hypomethylated fetal DNA fragment in a maternal plasma sample containing a corresponding hypermethylated maternal DNA fragment. | 2009-03-05 |
| 20090061426 | Binary signaling assay using a split-polymerase - The present invention provides methods, kits and compositions for the detection of an analyte. In the methods of the invention, a complex is formed between two or more analyte specific probes (ASP) and an analyte. The analyte specific probes each have a portion of a polymerase which interact to form a functional polymerase complex upon binding of the ASP to the analyte. The functional polymerase complex then generates a detectable signal which is indicative of the presence and/or amount of the analyte in the sample. | 2009-03-05 |
| 20090061427 | Gene Encoding Protein Responsible for Flocculation Property of Yeast and Use Thereof - The present invention relates to a gene encoding a protein responsible for flocculation property of yeast and use thereof in particular, a brewery yeast with appropriate flocculation property for producing desired alcoholic beverages, alcoholic beverages produced with said yeast, and a method for producing said beverages. More particularly, the present invention relates to a yeast to which suitable flocculation property for brewing desired alcoholic beverages was imparted by controlling expression level of HSP150 gene encoding a protein responsible for flocculation property of brewery yeast, especially non-ScHSP150 gene specific to a lager brewing yeast, to alcoholic beverages produced with said yeast and to a method for producing said beverages. | 2009-03-05 |
| 20090061428 | Thermal Reaction Device and Method for Using the Same - An M times.N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block. | 2009-03-05 |
| 20090061429 | Reactive surfaces, substrates and methods of producing and using same - Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an otherwise non-reactive surface for use in different applications including single molecule analyses. | 2009-03-05 |
| 20090061430 | Reactive surfaces, substrates and methods of producing and using same - Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an otherwise non-reactive surface for use in different applications including single molecule analyses. | 2009-03-05 |
| 20090061431 | Method of prognosing and diagnosing hereditary spastic paraplegia, mutant nucleic acid molecules and polypeptides - A method for diagnosing the presence of hereditary spastic paraplegia (HSP) or predicting the risk of developing HSP in a human subject, comprising detecting the presence or absence of a defect in a gene encoding a polypeptide comprising the sequence of FIG. | 2009-03-05 |
| 20090061432 | CSPCNA ISOFORM MODIFICATIONS AND USES THEREOF - Methods and compositions to detect the presence of csPCNA isoform by identifying one or more posttranslational modifications are disclosed. Methods to identify csPCNA isoform through posttranslational modifications including methylesterification levels are disclosed. | 2009-03-05 |
| 20090061433 | NUCLEOTIDE PRIMER SET AND NUCLEOTIDE PROBE FOR DETECTING GENOTYPE OF SERUM AMYLOID A1(SAA1) - Provided is a LAMP-amplification nucleotide primer set for detection of the genotype of single nucleotide polymorphisms C-13T, C2995T and T3010C of the SAA1 gene. Also provided is a nucleotide probe for detection of the amplification product amplified with the primer set according to the present invention. Further provided is a method of detecting the genotype of the single nucleotide polymorphisms C-13T, C2995T and T3010C of the SAA1 gene by using the primer set according to the present invention. | 2009-03-05 |
| 20090061434 | PRIMER COMPOSITION AND A KIT USEFUL FOR THE IDENTIFICATION OF PHYLLANTHUS - The present invention relates to an oligonucleotide primer set useful for the identification of | 2009-03-05 |
| 20090061435 | Methods and compositions for rapid amplification, capture and detection of nucleic acids and proteins - A method for detecting the presence of a nucleic acid template ( | 2009-03-05 |
| 20090061436 | PEPTIDE SEQUENCE THAT PROMOTES TUMOR INVASION - An isolated sequence SGSSEEKQNAVSSEET (OPNcPEP) SEQ ID NO: 8, and uses thereof. The peptide enhanced soft agar clone formation but did not support the growth of cells in plastic dishes, consistent with supporting anchorage-independence rather than growth. This sequence represented and is unique for a domain around the splice junction of OPN variant -c (OPN-c). OPN-c was expressed in a variety of tumor cell lines, but not in normal tissues (e.g., non-cancerous tissue) or in benign tumors. OPN-c antibody may be administered to a patient with a cancer associated with OPN-c expression to prevent the formation and growth of metastases. OPN-c may be used as a diagnostic to determine whether a patient has a malignant, rather than a benign, growth. OPN-c may be used to detect or identify agents that inhibit or mimic OPN-c expression or activity. | 2009-03-05 |
| 20090061437 | Nucleotide Analogs - The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids. | 2009-03-05 |
| 20090061438 | DETECTION OF MICROSATELLITE INSTABILITY AND ITS USE IN DIAGNOSIS OF TUMORS - Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer. | 2009-03-05 |
| 20090061439 | Methods and Compositions for Sequencing A Nucleic Acid - The invention provides nucleotide analogs and methods of using them in sequencing reactions. | 2009-03-05 |
| 20090061440 | METHOD FOR AMPLIFYING PLURAL NUCLEIC ACID SEQUENCES FOR DISCRIMINATION - The invention provides a method with fewer distribution of the amount of amplification among plural tags when the plural tags are used for multiplex detection using the tag. | 2009-03-05 |
| 20090061441 | EPIGENETIC SILENCING OF CYCLOOXYGENASE-2 AFFECTS CLINICAL OUTCOME IN GASTRIC CANCER - The present invention discloses methods of using the methylation status of the COX-2 gene promoter region as a biomarker for a gastric cancer patient to determine a prognosis and a treatment regimen, and to monitor the progress of a treatment regimen. | 2009-03-05 |
| 20090061442 | Screening assay to identify non-ATP-competitors targeting protein kinase A - Methods for screening compounds for their activity as a protein kinase A modulators are provided. The methods are based on fluorescence polarization of peptide probes to identify drug candidates that act by activating or inhibiting the catalytic function of PKA. In certain embodiments, the methods are adapted for high throughput screening. | 2009-03-05 |
| 20090061443 | Diagnostic and Therapeutic Targets for Leukemia - The present invention relates to methods of identifying candidate compounds for the treatment of leukemia and diagnostic methods based on histone methylation and HoxA5 promoter activity. | 2009-03-05 |
| 20090061444 | PHYTOCHROME-BASED FLUOROPHORES - Genetically-engineered fluorophore molecules with increased fluorescence are provided. These fluorophores are derived from the domains of phytochromes, and in particular bacterial phytochromes. Methods for generating these fluorophores and various applications of these fluorophores are also provided. | 2009-03-05 |
| 20090061445 | FLUX BALANCE ANALYSIS WITH MOLECULAR CROWDING - Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium; calculating metabolic flux reorganization in various environments and at various growth rates; and calculating the maximum metabolic rate and optimal metabolite concentrations and enzyme activities by applying a computational optimization method to a kinetic model of a metabolic pathway. The optimization methods use intracellular molecular crowding parameters and/or well as kinetic rates to assist in modeling metabolic activity. | 2009-03-05 |
| 20090061446 | METHOD FOR QUICKLY IDENTIFYING PATHOGENIC BACTERIA RESPONSIBLE FOR INFECTION - A system rapidly detects and identifies pathogenic bacteria responsible for infection (particularly septicemia), and selects an appropriate antimicrobial drug. A method according to the present invention for detecting and identifying pathogenic bacteria includes performing gene amplification such as real-time PCR, and analyzing the combination of the melting temperatures (Tm values) determined by gene amplification product melting curve analysis or the difference between the Tm values. Specifically, real-time PCR is performed using 4 to 16 primer sets including 1 to 7 primer sets for the 16S ribosomal RNA of bacteria, 1 to 6 primer sets for the 18S ribosomal RNA of fungi, and one primer set respectively for the spa gene and the mecA gene specific to MRSA, and the combination of the Tm values of the amplification product or the combination of the differences between the Tm values is compared with a database to identify pathogenic bacteria responsible for septicemia. Pathogenic bacteria responsible for infection (particularly septicemia) can be rapidly detected and identified using the method according to the invention so that a rapid septicemia diagnosis method and evidence-based medicine in septicemia treatment are implemented. | 2009-03-05 |
| 20090061447 | HIGH SPEED PARALLEL MOLECULAR NUCLEIC ACID SEQUENCING - A method and device is disclosed for high speed, automated sequencing of nucleic acid molecules. A nucleic acid molecule to be sequenced is exposed to a polymerase in the presence of nucleotides which are to be incorporated into a complementary nucleic acid strand. The polymerase carries a donor fluorophore, and each type of nucleotide (e.g. A, T/U, C and G) carries a distinguishable acceptor fluorophore characteristic of the particular type of nucleotide. As the polymerase incorporates individual nucleic acid molecules into a complementary strand, a laser continuously irradiates the donor fluorophore, at a wavelength that causes it to emit an emission signal (but the laser wavelength does not stimulate the acceptor fluorophore). In particular embodiments, no laser is needed if the donor fluorophore is a luminescent molecule or is stimulated by one. The emission signal from the polymerase is capable of stimulating any of the donor fluorophores (but not acceptor fluorophores), so that as a nucleotide is added by the polymerase, the acceptor fluorophore emits a signal associated with the type of nucleotide added to the complementary strand. The series of emission signals from the acceptor fluorophores is detected, and correlated with a sequence of nucleotides that correspond to the sequence of emission signals. | 2009-03-05 |
| 20090061448 | METHOD FOR IDENTIFYING OCULOSKELETAL DYSPLASIA IN DOGS - Provided are methods for identifying dogs as likely to be genetically normal, carriers of, or affected with Oculo-skeletal dysplasia (OSD) by determining the presence or absence of a drd2 COL9A2 mutation and/or a drd1 COL9A3 mutation. Also provided is a method for selective breeding of dogs and kits useful for carrying out the methods of the invention. | 2009-03-05 |
| 20090061449 | SYSTEMS AND METHODS FOR PROCESSING HYBRID SEED - The present disclosure provides for systems and method for producing hybrid seed. In various embodiments, the disclosure provides a system for the high-throughput, nondestructive sampling of seeds. In another embodiment, a high-throughput, nondestructive method for producing hybrid seeds comprises removing a sample from a plurality of seeds in the population while preserving the germination viability of the seed and analyzing the sample for the presence or absence of one or more genetic markers indicative of a male-sterile gene. | 2009-03-05 |
| 20090061450 | SYSTEM AND METHOD FOR DIAGNOSIS OF INFECTIOUS DISEASES - A biosafe apparatus is disclosed for assay and diagnosis of respiratory pathogens comprising a nasal sampling device, a single entry, disposable microfluidic cartridge for target nucleic acid amplification, and an instrument with on-board assay control platform and target detection means. | 2009-03-05 |
| 20090061451 | BIOSENSORS AND RELATED METHODS - Provided herein are biosensors that comprise a biological signal source linked to a substrate by a peptide nucleic acid spacer and methods of use of the biosensor. In one embodiment, the biosensor is used to detect prostate-specific antigen. | 2009-03-05 |
| 20090061452 | Polymorphisms in the human genes for OCT 1 and their use in diagnostic and therapeutic applications - The present invention relates to a polymorphic OCT1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit. | 2009-03-05 |
| 20090061453 | Methods and compositions for detecting colon cancers - This application describes methods and compositions for detecting and treating HLTF-associated neoplasia. Differential methylation of the HLTF nucleotide sequences has been observed in HLTF-associated neoplasia such as colon neoplasia. | 2009-03-05 |
| 20090061454 | DIAGNOSTIC AND PROGNOSTIC METHODS FOR LUNG DISORDERS USING GENE EXPRESSION PROFILES FROM NOSE EPITHELIAL CELLS - The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis from a nasal epithelial cell sample. The methods of the invention provide far less invasive method with a superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, such as lung cancer. | 2009-03-05 |
| 20090061455 | Use of Glycosaminoglycans to Reduce Non-Specific Binding in Immunoassays - An immunoassay reagent is provided which comprises an analyte binding agent in a diluent, and a glycosaminoglycan in an amount sufficient to reduce non-specific binding in an assay of a sample for the analyte. Provided is such an immunoassay reagent in which the analyte is troponin I, the analyte binding agent is a biotinylated anti-troponin I antibody, and the glycosaminoglycan is chondroitin sulfate. A sample composition is also provided which comprises a sample to be assayed for the presence of an analyte, an analyte binding agent, and a glycosaminoglycan other than heparin. Further provided is a method of detecting an analyte in a sample, in which non-specific binding is reduced in the method using a glycosaminoglycan. | 2009-03-05 |
| 20090061456 | Method for predicting progression free and overall survival at each follow-up time point during therapy of metastatic breast cancer patients using circulating tumor cells - A cancer test having prognostic utility in predicting time to disease progression, overall survival, and response to therapy in patients with MBC based upon the presence and number of CTC's. The Cell Spotter® System is used to enumerate CTC's in blood. The system immunomagnetically concentrates epithelial cells, fluorescently labels the cells and identifies and quantifies CTC's. The absolute number of CTC's detected in the peripheral blood tumor load is, in part, a factor in prediction of survival, time to progression, and response to therapy. The mean time to survival of patients depended upon a threshold number of 5 CTC's per 7.5 ml of blood. Detection of CTC's in metastatic cancer represents a novel prognostic factor in patients with metastatic cancers, suggests a biological role for the presence of tumor cells in the blood, and indicates that the detection of CTC's could be considered an appropriate surrogate marker for prospective therapeutic clinical trials. | 2009-03-05 |
| 20090061457 | Apolipoprotein E3 protein as a biomarker of Parkinson's disease - The present invention relates to an Apolipoprotein E3 protein as a biomarker for neurodegenerative disease, including Parkinson's disease, and the related diseases. More specifically, the present invention relates to the identification of an Apolipoprotein E3 protein, useful for the screening, diagnosis, and differentiation of Parkinson's disease from Alzheimer's disease, other neurodegenerative diseases, and normal controls. | 2009-03-05 |
| 20090061458 | Heterooligomeric Taste Receptor - Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell. | 2009-03-05 |
| 20090061459 | Reagents for the detection of protein phosphorylation in carcinoma signaling pathways - The invention discloses nearly 443 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Protein kinases (including Serine/Threonine dual specificity, and Tyrosine kinases), Adaptor/Scaffold proteins, Transcription factors, Phospoatases, Tumor supressors, Ubiquitin conjugating system proteins, Translation initiation complex proteins, RNA binding proteins, Apoptosis proteins, Adhesion proteins, G protein regulators/GTPase activating protein/Guanine nucleotide exchange factor proteins, and DNA binding/replication/repair proteins, as well as other protein types. | 2009-03-05 |
| 20090061460 | TEST APPARATUS, PRODUCTION METHOD THEREFOR AND TEST METHOD - Test apparatus for detecting an analyte (A) contained in a sample liquid, comprising a dry porous carrier ( | 2009-03-05 |
| 20090061461 | Phosphorylated or Non-Phosphorylated MPR as Diagnostic Marker or Therapeutic Target - A method of diagnosing diseases associated with aberrant biological phenotypes including contacting a sample to be tested with at least one isoform of membrane associated progesterone receptor component 1 (mPR) as a diagnostic marker, and determining or estimating the degree of phosphorylation of the membrane associated progresterone receptor component 1 (mPR). | 2009-03-05 |
| 20090061462 | Prion-specific peptide reagents - Peptide reagents that interact preferentially with the PrP | 2009-03-05 |
| 20090061463 | P-Selectin associated with Eosinophils as a marker for asthma and correlating with B-1 integrin activation - Methods are provided for the detection of P-selectin associated with eosinophils and for the use of P-selectin as a biological marker for asthma. In one embodiment, the present invention relates to methods for detecting P-selectin in a sample containing eosinophils and quantifying the total number of eosinophils. In another embodiment, the present invention relates a method for determining the proportion of eosinophils that are P-selectin positive and positive for at least partially activated β-1 integrin. In yet another embodiment, the present invention relates to kits for the detection of P-selectin and for the detection of eosinophils that are both P-selectin positive and positive for at least partially activated β-1 integrin. In still yet another embodiment, the invention relates to a method for monitoring a biological condition. | 2009-03-05 |
| 20090061464 | METHODS FOR DETECTING AND/OR QUANTIFYING A CONCENTRATION OF SPECIFIC BACTERIAL MOLECULES USING BACTERIAL BIOSENSORS - A real-time method employing a portable peptide-containing potentiometric biosensor, can directly detect and/or quantify bacterial spores. Two peptides for specific recognition of | 2009-03-05 |
| 20090061465 | COMPOSITION FOR ANALYZING DIABETES MELLITUS AND/OR RETINAL VASCULAR DISEASE AND ANALYZING METHOD THEREOF - Disclosed are composition for diagnosing a diabetes mellitus and a retinal vascular disease, a kit for diagnosing the retinal vascular disease including the protein, a gene encoding the protein, and a method for analyzing an antibody prepared by the diabetes mellitus and/or the retinal vascular disease using the same. | 2009-03-05 |
| 20090061466 | ANTI-DRUG ANTIBODY ASSAY - The invention provides a method for the immunological determination of an antibody against a drug antibody in a sample using a double antigen bridging immunoassay comprising a capture drug antibody and a tracer drug antibody, characterized in that the capture drug antibody is a mixture of said drug antibody conjugated to the solid phase at least two different antibody sites and the tracer drug antibody is a mixture of said drug antibody conjugated to the detectable label at least two different antibody sites. | 2009-03-05 |
| 20090061467 | Methods and Compositions for Measuring Canine BNP and Uses Thereof - The present invention describes compositions and methods designed to determine the presence or amount of BNP or fragments thereof in a sample. In particular, the invention provides materials that may be configured to bind canine BNP in a sandwich assay format. The present invention provides, inter alia, assays designed to rapidly and accurately measure BNP-related species in non-human animals. | 2009-03-05 |
| 20090061468 | REAGENT AND METHOD FOR MEASURING COAGULATION TIME OF BLOOD SAMPLE - A reagent kit for measuring coagulation time is described herein. This reagent comprises calcium chelator which interferes with the reaction between calcium and substance other than a coagulation factor in a blood sample, and which substantially does not interfere with coagulation reaction. | 2009-03-05 |
| 20090061469 | Methods and kits for assaying acetyl transferase or deacetylase activity - The invention provides methods and kits for characterizing the activity of an acetyl transferase or deacetylase. The method involves enzymatically acetylating or deacetylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically acylating the peptide substrate with acyl groups that differ in molecular weight from the enzymatically added or removed acetyl groups. Typically, deuterated acetic anhydride is used to non-enzymatically acylate the substrate. The fully acylated substrate is then characterized by mass spectrometry to determine the amino acid positions of the substrate that are enzymatically acetylated or deacetylated. | 2009-03-05 |
| 20090061470 | Use of Human Hepatocytes for Determining Liver Function and Liver Regeneration - The use of human hepatocytes to determine the liver function and the liver regeneration in a test person, in particular a patient, as well as the use of these human hepatocytes as parameters for prognoses. Also, an in-vitro method to determine the liver function of a test person, in particular a patient using human hepatocytes. | 2009-03-05 |
| 20090061471 | Methods and systems for selective fluorination of organic molecules - A method and system for selectively fluorinating organic molecules on a target site wherein the target site is activated and then fluorinated are shown together with a method and system for identifying a molecule having a biological activity. | 2009-03-05 |
| 20090061472 | ASSESSING THE RISK OF A MAJOR ADVERSE CARDIAC EVENT IN PATIENTS WITH CHEST PAIN - Methods for characterizing the near term risk of experiencing a major adverse cardiac event in a patient presenting with chest pain are provided. In one embodiment the method comprises determining the level of myeloperoxidase (MPO) activity in a bodily sample obtained from the patient. In another embodiment, the method comprises determining the level of MPO mass in a bodily sample obtained from the patient. In another embodiment, the method comprises determining the level of one or more select MPO-generated oxidation products in a bodily sample obtained from the patient. The select MPO-generated oxidation products are dityrosine, nitrotyrosine, chlorotyrosine, methionine sulphoxide or an MPO-generated lipid peroxidation product. Levels of MPO activity, MPO mass, or the select MPO-generated oxidation product in bodily samples from the test subject are then compared to a control value that is derived from measurements of MPO activity, MPO mass, or the select MPO-generated oxidation product in comparable bodily samples obtained from control population. Such comparison can also be used to determine the near term treatment of the patient. | 2009-03-05 |
| 20090061473 | Measurement of Carbonaceous Particles in Biological Samples - Disclosed is a method of quantitative estimation of carbonaceous particles in biological samples such as biological cells and tissues. | 2009-03-05 |
| 20090061474 | CELLS AND METHODS FOR ESTIMATION OF EFFECTS ON NEUROLOGICAL DYSFUNCTION - The invention provides neuron-derived cells obtained by transfecting a receptor-expressing nucleic acid having an aryl hydrocarbon receptor gene, wherein outgrowth of neurites is not observed without adding a substance for the aryl hydrocarbon receptor, and outgrowth of neurites is observed by adding the substance for the aryl hydrocarbon receptor. The invention also provides a method for determining the presence of neurotoxicity of a test substance, a method for acquiring a marker for determining the presence of neurotoxicity of the test substance, a method for acquiring a marker for neurological dysfunction, and a method for determining the effect of the test substance on neurological dysfunction using such cells. | 2009-03-05 |
| 20090061475 | Methods for Identifying Compounds for the Treatment of Type 1 Diabetes - The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic β cells with an amount of apolipoprotein CIII (“apoCIII”) effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit an apoCIII-induced increase in intracellular calcium concentration in the pancreatic β cells. The present invention also provides methods for treating patients with type I diabetes comprising administering to the patient an amount effective of an inhibitor of apoCIII to reduce apoCIII-induced increase in intracellular calcium concentration in pancreatic β cells. | 2009-03-05 |
| 20090061476 | Method and apparatus for imaging target components in a biological sample using permanent magnets - A system for enumeration of cells in fluids by image cytometry is described for assessment of target populations such as leukocyte subsets in different bodily fluids or bacterial contamination in environmental samples, food products and bodily fluids. Briefly, all cells in a biological sample are fluorescently labeled, but only the target cells are also magnetically labeled. A small, permanent magnet is inserted directly into the chamber containing the labeled sample. The magnets are coated with PDMS silicone rubber to provide a smooth and even surface which allows imaging on a single focal plane. The cells are illuminated and the images of the fluorescent light emitted by the target cells are captured by a CCD camera. Image analysis performed with a novel algorithm provides a count of the cells on the surface that can be related to the target cell concentration of the original sample. | 2009-03-05 |
| 20090061477 | Method and apparatus for imaging target components in a biological sample using permanent magnets - A system for enumeration of cells in fluids by image cytometry is described for assessment of target populations such as leukocyte subsets in different bodily fluids or bacterial contamination in environmental samples, food products and bodily fluids. Briefly, fluorescently labeled target cells are linked to magnetic particles or beads. In one embodiment, a small, permanent magnet is inserted directly into the chamber containing the labeled cells. The magnets are coated with PDMS silicone rubber to provide a smooth and even surface which allows imaging on a single focal plane. The magnet is removed from the sample and illuminated with fluorescent light emitted by the target cells captured by a CCD camera. In another embodiment, a floater having a permanent magnet allows the target cells to line up along a single imaging plane within the sample solution. Image analysis can be performed with a novel algorithm to provide a count of the cells on the surface, reflecting the target cell concentration of the original sample. | 2009-03-05 |
| 20090061478 | High-Speed Quantification of Antigen Specific T-Cells in Whole Blood by Flow Cytometry - The present invention discloses novel methods and compositions for identifying particular cell types in whole blood samples and defining either the concentration or ‘absolute count’ of these cells per unit volume of the sample. More specifically, the invention relates to methods for quantifying the antigen-specific T cells or defining the relative percentage of said cells in un-lysed whole blood. Further, the invention relates to kits for the preparation of whole blood samples for high-speed quantification of particular cell types, e.g. antigen specific T-cells, in said whole blood samples by flow cytometry. | 2009-03-05 |
| 20090061479 | MINERALIZED THREE-DIMENSIONAL BONE CONSTRUCTS - The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics. | 2009-03-05 |
| 20090061480 | NUCLEOTIDE SEQUENCE ENCODING A MODULATOR OF NF-KB - The present invention relates to nucleotide sequences encoding a modulator of NF-κB, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-κB-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-κB, methods of detecting modulator of NF-κB using the antibodies, methods of treatment associated with NF-κB activation and to methods of identifying compounds which modulate the activity of the modulator of NF-κB. | 2009-03-05 |
| 20090061481 | HIGHLY-EFFICIENT HYPERTHERMOPHILIC DNA LIGASE - Disclosed is a modified hyperthermophilic DNA ligase having improved DNA binding ability and reactivity. The modified hyperthermophilic DNA ligase has an amino acid sequence corresponding to the amino acid sequence of a heat-resistant DNA ligase derived from a thermophilic bacterium, a hyperthermophilic bacterium, a thermophilic archaebacterium, or a hyperthermophilic archaebacterium, except with at least two of charged amino acids in the C-terminal helix region each being substituted by alanine, threonine, or serine residues. | 2009-03-05 |
| 20090061482 | NUCLEOTIDE SEQUENCES OF CORYNEFORM BACTERIA CODED FOR PROTEINS PARTICIPATING IN L-SERINE METABOLISM AND METHOD FOR MICROBIAL PRODUCTION OF L-SERINE - This invention relates to the nucleotide sequence of coryneform bacteria coding for proteins which are involved in L-serine metabolism with reduced and switched off L-serine dehydratase activity. The invention also relates to microorganisms used in methods for producing L-serine. | 2009-03-05 |
| 20090061483 | ACID FUNGAL PROTEASES - The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and host cells including nucleic acid sequences coding for the proteases, methods for producing the proteases, enzyme compositions and methods employing said proteases. | 2009-03-05 |
| 20090061484 | ENZYMATIC HYDROLYSIS OF LIGNOCELLULOSIC FEEDSTOCKS USING ACCESSORY ENZYMES - Provided is an enzyme mixture for hydrolyzing a pretreated lignocellulosic feedstock to soluble sugars. The enzyme mixture comprises EG4 at a fractional concentration (f | 2009-03-05 |
| 20090061485 | Method of Producing an Antibody Using a Cell in Which the Function of Fucose Transporter Is Inhibited - The present invention relates to a method of producing a recombinant protein, particularly an antibody, using a cell in which the function of a fucose transporter is inhibited, and it also provides a cell in which the expression of fucose transporter genes on both homologous chromosomes is artificially suppressed. | 2009-03-05 |
| 20090061486 | METHOD FOR CELLULASE PRODUCTION - A fermentation process using hemicellulose-derived carbohydrates for the production of cellulase mixtures with a high proportion of cellulases relative to hemicellulases is provided. The cellulases produced by the process of the invention are further characterized by high specific productivity. The resulting cellulase mixtures comprise at least two times more cellulase than hemicellulase and are useful for the hydrolysis of cellulosic substrated, particularly, pretreated lignocellulosic substrate. | 2009-03-05 |
