07th week of 2010 patent applcation highlights part 37 |
Patent application number | Title | Published |
20100040964 | EXPOSURE APPARATUS, EXPOSURE METHOD AND METHOD OF MANUFACTURING DISPLAY PANEL SUBSTRATE - A range of a coordinate of drawing data supplied to a digital micromirror device (DMD) driving circuit | 2010-02-18 |
20100040965 | Exposure control for phase shifting photolithographic masks - Mask and integrated circuit fabrication approaches are described to facilitate use of so called “full phase” masks. This facilitates use of masks where substantially all of a layout is defined using phase shifting. In one embodiment, the phase shifting mask and the trim mask are exposed using substantially the same exposure conditions. These approaches facilitate better exposure profiles for the resulting ICs and can thus improve chip yield and increase throughput by reducing the need to alter settings and/or switch reticles between exposures. | 2010-02-18 |
20100040966 | ELECTROPHORETIC DISPERSIONS - This invention relates to improved electrophoretic dispersions and a method for improving the performance of an electrophoretic display. The invention also relates to a method of inducing or enhancing the threshold voltage of an electrophoretic dispersion. | 2010-02-18 |
20100040967 | HYPER-BRANCHED POLYMER OF AN ESTER TYPE, AND A TONER FOR ELECTROPHOTOGRAPHY USING THE SAME - [PROBLEMS] To produce a hyper-branched polymer having excellent resin strength, a good anti-blocking property and less environmental dependence. | 2010-02-18 |
20100040968 | Toner Compositions Including Silica Blends - A toner composition and method of providing such composition which may be used in a printer or printer cartridge. The composition may include toner particles mixed with silica particles having a primary particle size in the range of 30 nm to 60 nm present in the range of 0.1 to 2.0% by weight of the toner composition and silica particles having a primary particle size in the range of 60 nm to 150 nm present in the range of 0.1 to 2% by weight of the toner composition. | 2010-02-18 |
20100040969 | Toner Formulations with Tribocharge Control and Stability - A toner composition and a method of making a toner composition wherein toner particles having an average size in the range of 1-25 μm may be mixed with silica particles and alumina particles surface treated with an inorganic/organic compound. The silica particles may have a primary particle size in the range of 2 nm to 20 nm and may be present in the range of 0.01% to 3.0% by weight of the toner composition. The alumina particles surface treated with an inorganic/organic compound may be present in the range of 0.01% to 1.0% by weight of the toner composition. | 2010-02-18 |
20100040970 | POSITIVE RESIST COMPOSITION AND METHOD OF FORMING RESIST PATTERN - A positive resist composition including a resin component (A) which exhibits increased alkali solubility under action of acid and an acid-generator component (B) which generates acid upon exposure,
| 2010-02-18 |
20100040971 | PATTERN FORMING METHOD, AND RESIST COMPOSITION, DEVELOPER AND RINSING SOLUTION USED IN THE PATTERN FORMING METHOD - A pattern forming method comprising a step of applying a resist composition whose solubility in a negative tone developer decreases upon irradiation with an actinic ray or radiation and which contains a resin having an alicyclic hydrocarbon structure and a dispersity of 1.7 or less and being capable of increasing the polarity by the action of an acid, an exposure step, and a development step using a negative tone developer; a resist composition for use in the method; and a developer and a rinsing solution for use in the method, are provided, whereby a pattern with reduced line edge roughness and high dimensional uniformity can be formed. | 2010-02-18 |
20100040972 | PATTERN FORMING METHOD, AND RESIST COMPOSITION, DEVELOPER AND RINSING SOLUTION USED IN THE PATTERN FORMING METHOD - A pattern forming method comprising a step of applying a resist composition whose solubility in a negative tone developer decreases upon irradiation with an actinic ray or radiation and which contains a resin having an alicyclic hydrocarbon structure and a dispersity of 1.7 or less and being capable of increasing the polarity by the action of an acid, an exposure step, and a development step using a negative tone developer; a resist composition for use in the method; and a developer and a rinsing solution for use in the method, are provided, whereby a pattern with reduced line edge roughness and high dimensional uniformity can be formed. | 2010-02-18 |
20100040973 | COMPOSITION FOR FORMATION OF RESIST PROTECTION FILM, AND METHOD FOR FORMATION OF RESIST PATTERN USING THE SAME - Disclosed are: a composition for forming a resist protection film, which shows less damage to a resist film, can form a good, rectangular resist pattern, and can be used regardless of the structure of a resin used in a resist composition; and a method for forming a resist pattern by using the composition. Specifically, disclosed are: a composition for forming a resist protection film, which comprises (a) an alkali-soluble polymer and (b) an ether-based solvent; and a method for forming a resist pattern by using the composition. | 2010-02-18 |
20100040974 | UPPER LAYER FILM FORMING COMPOSITION AND METHOD OF FORMING PHOTORESIST PATTERN - An upper layer film forming composition for forming an upper layer film on the surface of a photoresist film includes (A) a resin dissolvable in a developer for the photoresist film and (B) a compound having a sulfonic acid residue group, the composition forming an upper layer film with a receding contact angle to water of 70° or more. The upper layer film forming composition of the present invention can form an upper layer film which has a sufficient transparency and is stably maintained without eluting the components into a medium without being intermixed with a photoresist film, can form a resist pattern with high resolution while effectively suppressing a defect, and can suppress a blob defect. | 2010-02-18 |
20100040975 | POSITIVE RESIST COMPOSITION AND PATTERN FORMING METHOD USING THE POSITIVE RESIST COMPOSITION - A positive resist composition comprises: (A) a compound capable of generating an acid upon irradiation with actinic rays or radiation; (B) a resin of which solubility in an alkali developer increases under action of an acid; and (C) a compound capable of decomposing under action of an acid to generate an acid. | 2010-02-18 |
20100040976 | HEAT-SENSITIVE IMAGING ELEMENT - A heat-sensitive imaging element includes an IR dye, and more particularly a heat-sensitive lithographic printing plate precursor includes the IR dye. A method for making the lithographic printing plate produces a print-out image of high contrast upon exposure to IR-radiation or heating. | 2010-02-18 |
20100040977 | RADIATION-SENSITIVE RESIN COMPOSITION - A radiation-sensitive resin composition includes a resin that includes a repeating unit shown by the following formula (1) and a solvent. The radiation-sensitive resin composition has an excellent performance as a radiation-sensitive acid generator, includes a resin that adversely affects the environment and a human body to only a small extent, and can form a resist film that has a high resolution and forms an excellent resist pattern. | 2010-02-18 |
20100040978 | PHOTOSENSITIVE LITHOGRAPHIC PRINTING PLATE MATERIAL - A lithographic printing plate material that is suitable for exposure with laser beams of 350 to 450 nm emission wavelength, being highly sensitive and excelling in developability. The lithographic printing plate material is a photosensitive lithographic printing plate material with a photosensitive layer containing (A) polymerization initiator, (B) compound having an ethylenic double bond, (C) sensitizing dye and (D) polymer binder, characterized in that the photosensitive layer contains, as polymerizable ethylenic double bond having compound (B), a reaction product obtained by reaction of (BM1) compound having in each molecule at least one polymerizable ethylenic double bond and one hydroxyl and (BM2) compound having in each molecule one secondary amino and one hydroxyl with (BM3) diisocyanate compound, wherein the ratio of BM1(mole)/BM2(mole) is in the range of 2.4 to 38.0. | 2010-02-18 |
20100040979 | SYSTEMS AND METHOD FOR FABRICATING SUBSTRATE SURFACES FOR SERS AND APPARATUSES UTILIZING SAME - The present invention is related in general to chemical and biological detection and identification and more particularly to systems and methods for the rapid detection and identification of low concentrations of chemicals and biomaterials using surface enhanced Raman spectroscopy. | 2010-02-18 |
20100040980 | METHOD AND APPARATUS FOR REFORMING FILM AND CONTROLLING SLIMMING AMOUNT THEREOF - In a film reforming method for reforming a film layer to be reformed by irradiating electron beams thereon, the electron beams are irradiated in a state where the film layer is cooled. Further, in a slimming amount controlling method for controlling a slimming amount of a resist film layer, the slimming amount thereof is controlled by the irradiation amount of electron beams irradiated thereon in a state where the resist film layer having a specified opening dimension is cooled. Furthermore, in a film reforming apparatus including a mounting unit for mounting thereon an object to be processed and an electron beam irradiating unit for irradiating electron beams on the object disposed on the mounting unit to thereby reform a film layer to be reformed, formed on an object, the electron beams are irradiated from the electron beam irradiating unit in a state where the film layer is cooled by a cooling unit provided in the mounting unit. | 2010-02-18 |
20100040981 | Tuning Optical Cavities - A tunable optical cavity can be tuned by relative movement between two reflection surfaces, such as by deforming elastomer spacers connected between mirrors or other light-reflective components that include the reflection surfaces. The optical cavity structure includes an analyte region in its light-transmissive region, and presence of analyte in the analyte region affects output light when the optical cavity is tuned to a set of positions. Electrodes that cause deformation of the spacers can also be used to capacitively sense the distance between them. Control circuitry that provides tuning signals can cause continuous movement across a range of positions, allowing continuous photosensing of analyte-affected output light by a detector. | 2010-02-18 |
20100040982 | METHOD FOR FORMING AN OPENING - A method for forming an opening is disclosed. First, a semiconductor substrate is provided, in which the semiconductor substrate includes at least one metal interconnects therein. A stacked film is formed on the semiconductor substrate, in which the stacked film includes at least one dielectric layer and one hard mask. The hard mask is used to form an opening in the stacked film without exposing the metal interconnects, and the hard mask is removed thereafter. A barrier layer is later deposited on the semiconductor substrate to cover a portion of the dielectric layer and the surface of the metal interconnects. | 2010-02-18 |
20100040983 | Compensation of Process-Induced Displacement - A method of manufacturing integrated circuits includes determining a process-induced displacement (e.g., a stress-induced displacement) between primary structures on a substrate and providing a photomask with mask features assigned to the primary structures. The distances between the mask features are set such that the process-induced displacement is compensated. | 2010-02-18 |
20100040984 | METHOD OF FABRICATING MICRO ELECTRO-MECHANICAL COMPONENT - A method of manufacturing a micro electro-mechanical component having a three-dimensional structure includes preparing a conductive substrate, selectively insulating or removing the conductive substrate to form a functional structure for performing a desired electro-mechanical function, forming a plated structure serving as an electrical connection portion on at least one surface of the functional structure, and mounting the functional structure on a circuit substrate so that the electrical connection portion is connected to a circuit pattern of the circuit substrate. | 2010-02-18 |
20100040985 | FINE MOLD AND METHOD FOR REGENERATING FINE MOLD - A fine mold comprises a regeneration target film forming a convex part of a formation surface, and a light shielding unit that is configured deeper than a bottom of the formation surface and that regenerates the regeneration target film. A manufacturing cost of a product having a three-dimensional structure can be reduced. | 2010-02-18 |
20100040986 | PROCESS FOR MANUFACTURING LIGHT GUIDE - The present invention relates to a process for producing an optical waveguide, including the steps of applying a cladding layer-forming resin onto a substrate and curing the resin to form a lower cladding layer; laminating a core layer-forming resin film on the lower cladding layer to form a core layer; subjecting the core layer to exposure to light and development to form a core pattern; and applying a cladding layer-forming resin over the core pattern to embed the core pattern therebeneath, and curing the resin to form an upper cladding layer, wherein the step of forming the core layer includes the steps of (1) allowing the core layer-forming resin film to be temporarily attached onto the lower cladding layer using a roll laminator, and (2) thermocompression-bonding the temporarily attached core layer-forming resin film onto the lower cladding layer under a reduced pressure. There is provided the process for producing an optical waveguide having a uniform core with a good productivity. | 2010-02-18 |
20100040987 | Method for Exposing an Area on a Substrate to a Beam and Photolithographic System - Embodiments of the invention describe a method for exposing an area on a substrate to a beam. The method includes adjusting a focus offset of the beam with respect to the area on the substrate, tilting the beam or tilting the substrate, and exposing the area on the substrate with the beam, thereby generating locations within the area exposed with different foci. Furthermore embodiments describe computer programs for controlling a photolithographic system to do the same and a photolithographic system for doing the same. | 2010-02-18 |
20100040988 | SPIN BOWL COMPATIBLE POLYAMIC ACIDS/IMIDES AS WET DEVELOPABLE POLYMER BINDERS FOR ANTI-REFLECTIVE COATINGS - Anti-reflective compositions and methods of using these compositions to form circuits are provided. The compositions comprise a polymer dissolved or dispersed in a solvent system. In a preferred embodiment, the polymers of the composition include recurring monomers having the formulas | 2010-02-18 |
20100040989 | Combustor Control - An apparatus and method for controlling a combustor on a vapor recovery process system which prevents excessive oxygen from entering a natural transmission line and which prevents the need to vent natural gas to the atmosphere. | 2010-02-18 |
20100040990 | Precombustion chamber for canned heat products - This invention provides an improved chamber within the can of a canned heat product that allows more complete combustion due to a better mixing of air and gasified fuel which eminates from fuel on the surface of a fibrous fill. This improved mixing is the result of pulling cold outside air into the outer annulus of the combustion chamber where mixing occurs prior to ignition and also cools the fuel holding fiber as well as providing a steady height point of maximum temperature due to the combustion. | 2010-02-18 |
20100040991 | IN-LINE ANNEALING APPARATUS AND METHOD OF ANNEALING SUBSTRATE USING THE SAME - An in-line annealing apparatus and a method of annealing a substrate using the in-line annealing apparatus in which a plurality of heating devices provide a transportation path of a substrate and heat the substrate transported along the transportation path to a crystallization temperature, and an instantaneous high-temperature annealing unit heats the substrate positioned in the transportation path between the heating devices to a instantaneous annealing temperature. The in-line annealing apparatus and the method of annealing a substrate using the same provide a highly efficient annealing process that can be performed at various temperatures including a high temperature of 700° C. or higher. | 2010-02-18 |
20100040992 | ASCENDING/DESCENDING APPARATUS AND COMPLEX SINTERING FURNACE USING THE SAME - Provided is a complex sintering furnace to sequentially perform a bake-out process and a sintering process for molding ceramic products. The complex sintering furnace includes: a support frame; a pair of furnace bodies supported on the top of the support frame and having a built-in heat insulator covered by a disc-shaped cover; a pair of rails arranged under the support frame in parallel in a length direction along arrangement of the furnace bodies; a rotating base horizontally transferred along the rails and rotatably connected to bottoms of the furnace bodies when the rotating base is vertically transferred directly under the bottoms of the furnace bodies, the rotating base including a separately rotating setter mounted the top thereof; and an ascending/descending apparatus mounted under the rotating bases and having a ball-screw type rotation shaft to vertically ascend/descend the rotating base at the same time of the separate rotation of the setters. Accordingly, the production efficiency of the ceramic products can be significantly improved by rapidly transferring to the post-processes and simultaneously performing the bake-out process and the sintering process. | 2010-02-18 |
20100040993 | APPARATUS AND METHOD FOR DETECTING DENTAL PATHOLOGIES - A diagnostic tool for detection of dental pathology is provided that functions as a self-contained, handheld unit. The tool includes a light probe and a housing within which are located an optical source, an optical detector, an analysis processor and a power source. The components within the housing are integrated on a support which is removable from the housing. The housing is in multiple pieces which may be connected together during operation, and disconnected to allow removal of the support. This allows for sterilization of the housing and light probe without the electrical components of the device. | 2010-02-18 |
20100040994 | Reciprocal Reverse Rotation Endodontic File - A single use, reciprocal reverse rotation, endodontic file includes a plurality of spaced apart helical flutes with spiraled lands therebetween. The lands have an edge with a positive cutting angle when the file is rotated in one direction and a scraping angle when rotated in the opposite direction. The file provides for sequential rotation of a selected angle in a forward direction followed by rotation of a slightly less angle in a reverse direction. In one embodiment, the cross-sectional area of the flutes is concave polygonal-shaped at a proximal end of the file and square-shaped at the distal end. In another embodiment, the cross-sectional area of the flutes is convex arcuate-shaped, the lands lying normal to the central longitudinal axis of the file. The handle portion of the file may be configured for use in a rotary handpiece or for manual rotation. | 2010-02-18 |
20100040995 | Applicator Device - The invention relates to an applicator device ( | 2010-02-18 |
20100040996 | METHOD FOR MANUFACTURING A PROSTHESIS MADE PRIOR TO IMPLANT PLACEMENT - A dental implant-to-prosthesis interface is provided, allowing lateral misalignments between the fixture heads and the connections to the prosthesis. This type of interface, in combination with a dedicated screw for fixing implant to prosthesis, allows the use of a truly pre-manufactured prosthesis for immediate loading on the implant. This system is particularly suited for cases with multiple implant placement. | 2010-02-18 |
20100040997 | Artificial teeth - The invention enables to arrange artificial molar teeth at appropriate positions according to the oral cavity environment of each patient without requiring advanced techniques or experiences. The invention relates to artificial molar teeth having maxillary molar teeth | 2010-02-18 |
20100040998 | Paint Memorialization Kit - A paint memorialization kit includes a plurality of elongate color identifying elements, each having generally planar front and rear sides and having opposed first and second ends. Each second end includes a tab extending upwardly therefrom for use in identifying the color identifying elements. Each front side first end includes indicia requesting color information, texture information, and brand information of paint received on a respective second end. The kit includes a case having a first area for receiving the color identifying elements and a second area for receiving paint paraphernalia, the first area including partitions for separating the color identifying elements from one another and maintaining the color identifying elements in an upright configuration. The case includes a lid movable to selectively cover and expose the first and second areas. | 2010-02-18 |
20100040999 | Education board game system and related method - The invention provides an academic board game to assist in student education associated with a curriculum related to one or more players of the board game. The board game system includes a game board having a plurality of defined spaces that define a path of travel, a plurality of player tokens each representing a player and a player position on the path of travel traversed over the game board during play, a plurality of pre-defined playing cards having associated questions and answers, the pre-defined playing cards being color-coded according to subject matter, and a plurality of custom playing cards on which questions and answers directly related to at least one individual player's curriculum is placed. During play, the custom playing cards are used in part along with the pre-defined playing cards to determine player advancement on the game board. | 2010-02-18 |
20100041000 | System and Method for Controlling the Presentation of Material and Operation of External Devices - By performing a comparison of words spoken by a speaker and defined material which is presented to the speaker, information can be determined which allows for the convenient control of the presentation of material and external devices. A comparison of a speaker's words with defined material can be beneficially used as an input for controlling the operation of an exercise apparatus, video games, material presented to an audience, and the presentation of the material itself. Similar feedback loops can also be used with measurement and stimulation of neurophysiologic states, to make the activity of reading more enjoyable and convenient, or for other purposes. | 2010-02-18 |
20100041001 | VISUAL DIVIDED ATTENTION TRAINING - Computer-implemented method for enhancing cognition of a participant. A first target image of a set of target images is visually presented for a specified presentation time at a first location in a visual field that includes multiple peripheral locations, each at least a specified distance from the first location. Substantially simultaneously, a first peripheral location in the visual field is visually indicated for the presentation time, after which the visually presenting and indicating are ceased. Candidate target images with a specified discriminability are visually presented, including the first target image. The participant is required to select the target image from among the candidates. If the participant correctly selected the first target image, the participant is required to select the first peripheral location from the multiple peripheral locations. The presentation time is adaptively modified based on the correctness/incorrectness of the participant's selections. The process is repeated to improve the participant's cognition. | 2010-02-18 |
20100041002 | PORTABLE TERMINAL DEVICE HAVING FUNCTION OF MEASURING MENTAL FATIGUE AND ITS MEASURING METHOD - A portable terminal device ( | 2010-02-18 |
20100041003 | SYSTEMS AND METHODS FOR SIMULATING EFFECTS OF AGE-RELATED COGNITIVE OR PHYSICAL DECLINE - Certain aspects and embodiments of the present invention provide a system for allowing a user to experience a simulation of an age-related medical condition. The system can include eyewear, footwear, handwear, and an audio recording. The eyewear can include two colored lenses. Each lens includes a marking that can at least partially bock central vision of the user and a lens sideguard that can at least partially block peripheral vision of the user. The footwear includes a surface that can be located adjacent to a sole of the user. The surface includes protrusions that can at least indirectly contact the sole. The handwear can impair physical sensory of the user. The audio recording is stored on a medium and includes voiced instructions and static for a first pre-set time and static for a second pre-set time. The voiced instruction identifies home-based tasks for the user to perform during the second pre-set time while wearing the eyewear, footwear, and handwear. | 2010-02-18 |
20100041004 | SURGICAL BURR HOLE DRILLING SIMULATOR - A system, method and device for simulating a medical procedure include a haptic mechanism controllable to provide feedback to a user manipulating a medical device. In an embodiment, a pair of three degree of freedom haptic devices are coupled to provide six degree of freedom measurement and force/moment feedback to the user. The six degree of freedom haptic device may be configured to provide different resolutions for different degrees of freedom, depending on simulation requirements. In an embodiment, a load cell is used to provide higher resolution in a dimension determined to be of greater criticality to realistic simulation. | 2010-02-18 |
20100041005 | Tissue-mimicking phantom for prostate cancer brachytherapy - A phantom for prostate cancer brachytherapy has a prostate tissue phantom shaped like a real prostate gland, a perineal tissue phantom surrounding the prostate tissue phantom, a skin tissue phantom separating the perineal tissue phantom from an outside environment, and an enclosure. The prostate tissue phantom is a polyvinyl alcohol cryogel (PVA-C) having undergone 3-5 freeze-thaw cycles and having 10-20% w/w PVA in a solvent (e.g. water), 4-8% w/w oil and an amount of acoustic scattering particles to ultrasonically distinguish the prostate-tissue phantom from its surroundings. The perineal tissue phantom is a PVA-C having undergone 1-2 freeze-thaw cycles and having 10-20% w/w PVA in a solvent, 4-8% w/w oil and an amount of acoustic scattering particles to ultrasonically distinguish the perineal tissue phantom from its surroundings. The skin tissue phantom is a PVA-C having undergone at least 6 freeze-thaw cycles and having 15-25% w/w PVA in a solvent. The phantom mimics the imaging and mechanical properties of the prostate and surrounding tissues, providing a realistic phantom for prostate cancer brachytherapy. | 2010-02-18 |
20100041006 | INTERACTIVE INSTRUCTIONAL BOOK AND RELATED TOY SYSTEM - An instructional toy, comprising: a doll having an outside portion and an inside portion, the inside portion removably containing at least one body part; a book having a related shape of the at least one body part being substantially the same size and shape as the at least one body part and indicia on at least one page of the book related to the at least one body part. | 2010-02-18 |
20100041007 | Method and System for Knowledge Diagnosis and Tutoring - The present invention includes method and system for intelligent knowledge diagnosis and tutoring in any knowledge domain. It differs from prior arts with new knowledge model for knowledge presentation and heuristic algorithms. The knowledge model allows the present invention to be applied to curricula in different knowledge domains quickly and cost effectively. | 2010-02-18 |
20100041008 | INTEGRATED LEARNING MANAGEMENT SYSTEM AND METHODS - Integrated learning management is provided for a computer assisted learning system having an instructor led training component (ILT) and a computer based training (CBT) component. The CBT component has a plurality of training materials and a content management service (CMS) that (i) controls an interface between the ILT component and the CBT component. An integrated learning management system and method enforces a plurality of standards upon the ILT component and the CBT component, each said standard governing at least one of quality, uniformity and branding. | 2010-02-18 |
20100041009 | METHOD FOR ISOLATION OF AFTERBIRTH DERIVED CELLS - A method for extracting cells from afterbirth tissue, including placing the afterbirth into a perfusion circuit prior to exsanguination, extracting the cells from the afterbirth with digestive enzymes and mechanically recovering cells from the digested afterbirth tissue, and isolating the cells from the perfusate and digestion mix. Also disclosed is a cell line derived from afterbirth using the two-step pulsatile perfusion extraction method. | 2010-02-18 |
20100041010 | Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue - The invention relates to a method of treatment of collagenous connective tissue removed from a donor for implant into a recipient which is re-habited or re-colonized by host cells without an immune rejection and inflammatory reaction. After removal from the donor the tissue is trimmed and thereafter soaked in a cold stabilizing solution having a temperature range of 4 to 10 degrees centigrade. The tissue is then soaked at a predetermined temperature in a polyglycol, salt, hydrogen peroxide, and phosphate buffer first solution of predetermined quantities and concentrations and of sufficient ionic strength to permit ground substances to dissociate such that the collagen fibers remain stable. The tissue is then soaked in an alcohol and water solution at a predetermined temperature for a sufficient period of time to remove the residue of the first solution. Following the removal of the residue, the tissue is soaked at a predetermined temperature in a third solution of an anti-inflammatory agent, an anti-thrombic agent, alcohol, and water or sequentially in an anti-inflammatory agent, alcohol, and water solution, and then in an anti-thrombic agent, alcohol and water solution and thereafter stored. | 2010-02-18 |
20100041011 | Reference Control for Cell by Cell Analysis - A reference control for cell by cell analysis on flow cytometric analyzers contains cellular analogs made of permeated blood cells containing therein aggregated intracellular proteins and preserved antigenic sites thereof, having cellular membrane permeable to antibodies and a suspension medium. The reference control is frozen after being prepared and thawed prior to use. The cellular analogs further contain a fluorescence marker therein. Further disclosed are a method of making the reference control and a method using the reference control, as an internal or stand-alone control, for measurements of cellular hemoglobin and cellular hemoglobin variant of a blood sample. | 2010-02-18 |
20100041012 | Rationally designed antibodies - Antibodies or fragments thereof having CDR regions replaced or fused with biologically active peptides are described. Flanking sequences may optionally be attached at one or both the carboxy-terminal and amino-terminal ends of the peptide in covalent association with adjacent framework regions. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities. | 2010-02-18 |
20100041013 | ASSAY FOR A HEALTH STATE - The invention relates to an assay for determining a health state of a subject using a combination of detecting the presence of a virus and detecting the presence of a genomic target or marker indicative of a health state. | 2010-02-18 |
20100041014 | Biological targeting compositions and methods of using the same - Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described. | 2010-02-18 |
20100041015 | COMPETITIVE ENZYME LINKED IMMUNOSORBENT ASSAY (C-ELISA) FOR THE DETECTION OF A FLAVIVIRUS SPECIFIC ANTIBODY - A competitive enzyme-linked immunosorbent assay (C-ELISA), using flavivirus member specific immunological agents was developed to detect antibody specific to members of the flaviviruses indicative of exposure to flavivirus. The test is based on a competition for epitope binding on the envelope protein of the flavivirus antigen captured using anti-flavivirus IgA in the presence of flavivirus positive serum. This test has comparable sensitivity specificity and speed to the virus neutralization assay (VNT). C-ELISA is a versatile technique, which could have various applications. Slight modifications of this protocol could lead to a C-ELISA-based detection method of secondary infection or one that could be used for serotype specific sero-epidemiological studies and/or vaccine evaluation. The protocol developed for C-ELISA was demonstrated using dengue lysate antigen and dengue specific monoclonal antibody. This can be used against other flaviviruses and the results for Japanese encephalitis illustrates this. | 2010-02-18 |
20100041016 | METHODS FOR DETECTING ORGANISMS AND ENZYMATIC REACTIONS USING RAMAN SPECTROSCOPY AND AROMATIC COMPOUNDS COMPRISING PHOSPHATE - The present disclosure provides systems for the rapid and sensitive detection of organisms and molecules in samples. Reactants that produce Raman-active products are used in combination with Raman light scattering. Such compounds may comprise phosphates permitting the detection of phosphatases. The present disclosure can also be used to measure enzyme-kinetics. | 2010-02-18 |
20100041017 | FLUORESCENT SEMICONDUCTOR MICROPARTICLE ASSEMBLY, FLUORESCENT LABELING AGENT ASSEMBLY FOR BIOLOGICAL SUBSTANCE, AND BIOIMAGING METHOD AND BIOLOGICAL SUBSTANCE ANALYSIS METHOD USING THE ASSEMBLIES - Disclosed is a fluorescent semiconductor microparticle assembly comprising at least three kinds of fluorescent semiconductor microparticles with an average particle size of from 1 to 10 nm, having the same chemical composition, a different average particle size and a different emission maximum wavelength in the emission spectra, wherein a standard deviation of emission intensity in each of the at least three kinds of fluorescent semiconductor microparticles is not more than 15%. | 2010-02-18 |
20100041018 | METHOD TO DETECT VIRUS RELATED IMMUNOLOGICAL MARKERS FOR THE DIAGNOSIS OF HEPATITIS C VIRUS INFECTION - This invention discloses using SPR technology to simultaneously and qualitatively measure the presence of HCV-associated immunological markers in a serum sample for the diagnosis of HCV infection. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of HCV related antigen proteins used for the diagnosis of HCV infection. | 2010-02-18 |
20100041019 | Methods of Screening for Respiratory Synctial Virus and Human Metapneumovirus - Provided are nucleic acid primers and probes for use in diagnostic assays to screen for respiratory infections, such as respiratory syncytial virus (“RSV”) and human metapneumovirus (hMPV). The primers and probes may be used to screen for RSV or hMPV in a singleplex assay or they may be used in a multiplex assay to simultaneously screen for RSV and hMPV, or RSV and/or hMPV and any of the following viruses: influenza A, and influenza B, parainfluenza viruses, adenovirus, coronavirus, and rhinoviruses. | 2010-02-18 |
20100041020 | Methods for detecting the presence, location or quantity of targets using novel dyes - The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified by the addition of charged and polar groups to provide beneficial properties. | 2010-02-18 |
20100041021 | APPARATUS AND METHOD FOR MEASURING CONCENTRATION OF MOLECULES THROUGH A BARRIER - An apparatus and method for detecting the presence and measuring the concentrations of molecules through a barrier and/or at a distance utilizes the principle of chemical/electrostatic attraction (hereinafter “affinity”), i.e., the affinity between charged atoms and molecules that cause their chemical interactions and reactions, to infer, based on the behavior of molecules on one side of the barrier, the presence and concentration of corresponding molecules on the other side of the barrier. The invention is useful, by way of example and not limitation, in non-invasively measuring glucose levels of diabetic patients. | 2010-02-18 |
20100041022 | Novel assay for the separation and quantification of hemagglutinin antigens - Described are methods for separating hemagglutinin (HA) antigens, comprising the steps of applying a reduced and derivatized antigen preparation comprising solubilized HA antigens and a detergent in a pH controlled solution, on a Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) column; and eluting the HA antigens from the column with an ion pairing agent in an organic mobile phase. The invention further relates to quantifying methods using the methods for separating the antigens with the further step of measuring the peak area of the eluted antigen in a chromatogram resulting from the elution step. | 2010-02-18 |
20100041023 | Inactivated FCV vaccines - The present invention relates to improved inactivated feline calicivirus (FCV) vaccines. The invention also provides a process for producing stabilized inactivated FCV, and the use of such stabilized inactivated FCV, in the production of FCV immunogenic compositions. The invention further provides methods of inducing an immune response in an animal of the Felidae family, preferably a cat, using the immunogenic compositions according to the invention. | 2010-02-18 |
20100041024 | Bisulfite Conversion of DNA - The present invention relates to an improved method for the bisulfite conversion of DNA. In certain time-temperature ranges the efficacy of the bisulfite conversion is clearly improved. By combination with denaturating solvents, new reaction conditions and new purification methods the efficacy can be further increased The converted DNA can subsequently be analysed by different methods. The present invention facilitates the analysis of cytosine methylation. | 2010-02-18 |
20100041025 | Compositons, methods and kits for real-time nucleic acid analysis in live cells - The present invention includes compositions, methods and kits for the real-time detection of transcription and translation in live cells, tissues and organisms. The present invention further provides method for the rapid sequencing of nucleic acids without using conventional sequencing techniques or reactions. | 2010-02-18 |
20100041026 | Method for Identiflying Modulators of Rufy2 Useful for Treating Alzheimer's Disease - Compositions and methods for identifying modulators of RUFY2 are described. The methods are particularly useful for identifying analytes that antagonize RUFY2's effect on processing of amyloid precursor protein to Aβ peptide and thus useful for identifying analytes that can be used for treating Alzheimer disease. | 2010-02-18 |
20100041027 | METHODS OF ASSESSING CORONARY ARTERY DISEASE - An association between the Ala allele of the P12A variant of the human PPARγ gene and development of CAD, particularly premature CAD, in individuals, and specifically in women, particularly Caucasian women, is described, as are methods of assessing or predicting the likelihood or risk that an individual, such as a woman, will develop premature CAD. Single nucleotide polymorphisms in the human resistin gene, human resistin gene variants, gender-related increase in premature coronary artery disease, methods of assessing or aiding in assessing the risk that an individual will develop premature CAD, and methods of predicting the likelihood or aiding in predicting the likelihood that an individual will develop premature CAD are described. | 2010-02-18 |
20100041028 | Zinc finger binding domains for GNN - Zinc finger-nucleotide binding polypeptides having binding specificity for target nucleotides containing one or GNN triplets are provided. Compositions containing such polypeptides and the use of such polypeptides and compositions for regulating gene expression are also provided. | 2010-02-18 |
20100041029 | SYNTHESIS OF FOUR COLOR 3'O-ALLYL, MODIFIED PHOTOCLEAVABLE FLUORESCENT NUCLEOTIDES AND RELATED METHODS - This invention provides a process for making 3′-O-allyl-dGTP-PC-Biodopy-FL-510, 3′-O-allyl-dATP-PC-ROX, 3′-O-allyl-dCTP-PC- and 3′-O-allyl-dUTP-PC-R6G, and related methods. | 2010-02-18 |
20100041030 | DISPLACEMENT ASSAY FOR DETECTING NUCLEIC ACID OLIGOMER HYBRIDIZATION EVENTS - Described is a method for detecting nucleic acid oligomer hybridization events that comprises the steps providing a modified surface, the modification consisting in attaching at least one type of probe nucleic acid oligomer, providing at least one type of signal nucleic acid oligomer, the signal nucleic acid oligomers being modified with at least one detection label and the signal nucleic acid oligomers having a section that is complementary or largely complementary to the probe nucleic acid oligomers, providing a sample having target nucleic acid oligomers, bringing a defined quantity of the signal nucleic acid oligomers into contact with the modified surface, bringing the sample and the target nucleic acid oligomers contained therein into contact with the modified surface, detecting the signal nucleic acid oligomers and comparing the values obtained when detecting the signal nucleic acid oligomers with reference values. According to the present invention, the signal nucleic acid oligomers have a larger number of bases than the probe nucleic acid oligomers and exhibit at least one docking section, the docking section exhibiting no structure that is complementary or largely complementary to any section of the probe nucleic acid oligomers, and the target nucleic acid oligomers having a section that is complementary or largely complementary to the docking section. | 2010-02-18 |
20100041031 | Optoelectronic detection system - The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples. | 2010-02-18 |
20100041032 | COMPOSITION AND METHODS FOR THE DETECTION OF CRIPTO-3 - The present invention is based, at least in part, on the discovery that the pseudogene TDGF3 (Cripto-3) is expressed in cells and, in particular, that TDGF3 overexpression is associated with transformation of a cell, e.g., TDGF3 is overexpressed in cancer cell lines and cells from tumor tissue. Accordingly, the invention provides compositions, kits, and methods for detecting the presence of a TDGF3 polynucleotide or polypeptide in a sample. The invention further provides compositions, kits and methods for assessing whether a cell is transformed as well as for assessing whether a patient is a suitable candidate for an anti-Cripto antibody therapy. | 2010-02-18 |
20100041033 | SITE SPECIFIC SYSTEM FOR GENERATING DIVERSITY PROTEIN SEQUENCES - This invention relates to the diversification of nucleic acid sequences by use of a nucleic acid molecule containing a region of sequence that acts as a template for diversification. The invention thus provides nucleic acid molecules to be diversified, as well as those which act as the template region (TR) and in concert with the TR for directional, site-specific diversification. Further provided are methods of preparing and using these nucleic acid sequences. | 2010-02-18 |
20100041034 | METHOD FOR MANIPULATING SAMPLES WITH MAGNETIC NUCLEATION NANOPARTICLES - A method for manipulating a sample by utilizing a nucleic acid binding substance which has affinity for nucleic acid polymers. The nucleic acid binding substance is comprised of a nucleic acid binding element capable of specific binding to nucleic acid molecules and connected to a nucleation nanoparticle having paramagnetic properties. | 2010-02-18 |
20100041035 | IDENTIFICATION OF CENTROMERE SEQUENCES AND USES THEREFOR - Provided herein are methods for identifying centromeres and centromeres identified by such methods. Centromeres of organisms such as algae, fungi, and protists can be used, for example, for constructing artificial chromosomes and cells containing such artificial chromosomes. | 2010-02-18 |
20100041036 | GENOMIC MORSE CODE - The present invention relates to a method of detection of the presence of at least one domain of interest on a macromolecule to test, wherein said method comprises the following steps: a) determining beforehand at least two target regions on the domain of interest, designing and obtaining corresponding labeled probes of each target region, named set of probe of the domain of interest, the position of these probes one compared to the others being chosen and forming the specific signature of said domain of interest on the macromolecule to test; b) after spreading of the macromolecule to test on which the probes obtained in step a) are bound, detection of the position one compared to the others of the probes bound on the linearized macromolecule, the detection of the signature of a domain of interest indicating the presence of said domain of interest on the macromolecule to test, and conversely the absence of detection of signature or part of signature of a domain of interest indicating the absence of said domain or part of said domain of interest on the macromolecule to test. | 2010-02-18 |
20100041037 | GENETIC VARIANTS CONTRIBUTING TO RISK OF PROSTATE CANCER - The present invention is characterised by certain genetic variants being susceptibility variants for prostate cancer. The invention relates to methods of determining increased susceptibility to prostate cancer, as well as methods of determining decreased susceptibility to prostate cancer, using such variants. The invention further relates to kits for determining a susceptibility to prostate cancer. | 2010-02-18 |
20100041038 | METHOD FOR DISCRIMINATING SINGLE NUCLEOTIDE POLYMORPHISMS - A method for discriminating single nucleotide polymorphisms (SNPs) offers improved sensitivity and specificity. A test kit is also provided. The method may be for genotyping in typing assays applied to a biological sample. The method may include steps of performing a real-time amplification of the target, generating multiple copies of amplicons, in presence of at least two different labeled probes, each probe allowing real-time detection at the SNP position of both the wildtype and at least one possible mutation, assessing the discriminatory variable value(s) based on the signals of each combination of two detection probes, and discriminating between the genotypes. The methods may be for diagnostic, preventive and therapeutic applications. | 2010-02-18 |
20100041039 | Analysis of nucleic acid obtained from nucleated red blood cells - The present invention is particularly useful for extracting DNA from nucleated RBCs. Therefore, the methods of the invention can be applied towards the genetic analysis of avians, fish, reptiles and amphibians. | 2010-02-18 |
20100041040 | Internally Controlled Multiplex Detection and Quantification of Microbial Nucleic Acids - The present invention relates to new methods and uses for the detection and quantification of microbial nucleic acids employing an internal quantitative reference. Preferred methods are based on the amplification of nucleic acids, preferably the polymerase chain reaction. Further provided are kits comprising components for performing said methods and uses. Moreover, an analytical system for advantageously performing the method according to the invention is disclosed. | 2010-02-18 |
20100041041 | NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING - The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, photocleavable, enzymatically cleavable, or non-photocleavable groups and methods for their use in DNA sequencing and its application in biomedical research. | 2010-02-18 |
20100041042 | BREEDING AND MILKING COWS FOR MILK FREE OF BETA-CASEIN A1 - A milk or other dairy product, capable of minimising the onset of disease such as coronary heart disease or enhancing the immune response is derived from animals which are substantially free of the β-casein A allele. Bulk milk can be produced by testing for and culling cows who test positive for the β-casein A allele, or by producing immunoglobulins and other immune response proteins, in cow's milk from animals not possessing the β-casein A | 2010-02-18 |
20100041043 | METHOD FOR THE DIAGNOSIS AND FOLLOW-UP OF SCHIZOPHRENIA AND OTHER MENTAL AND NEUROLOGICAL DISORDERS - A method for the diagnosis and follow up of a mental disorder or of a neurodegenerative disorder in an individual, comprises: (i) measuring mRNA of D | 2010-02-18 |
20100041044 | AMPLICON MELTING ANALYSIS WITH SATURATION DYES - Methods are provided for nucleic acid analysis wherein a target nucleic acid that is at least partially double stranded is mixed with a dsDNA binding dye having a percent saturation of at least 50% to form a mixture. In one embodiment, the nucleic acid is amplified in the presence of the dsDNA binding dye, and in another embodiment a melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye as the mixture is heated. Dyes for use in nucleic acid analysis and methods for making dyes are also provided. | 2010-02-18 |
20100041045 | NUCLEIC ACID FLUORESCENT STAINS - The present invention provides fluorescent dye compounds and methods of using the compounds for the staining of nucleic acids including qPCR applications. In particular, the dye compounds comprise heterocyclic molecules with hydroxy alkyl and aromatic substituents, and the dye compounds form highly fluorescent complexes upon nucleic acid binding. | 2010-02-18 |
20100041046 | METHOD AND APPARATUS FOR THE DISCRETIZATION AND MANIPULATION OF SAMPLE VOLUMES - Embodiments of the present invention relate to methods and apparatuses for the discretization and manipulation of sample volumes that is simple, robust, and versatile. It is a fluidic device that partitions a sample by exploiting the interplay between fluidic forces, interfacial tension, channel geometry, and the final stability of the formed droplet and/or discretized volume. These compartmentalized volumes allow for isolation of samples and partitioning into a localized array that can subsequently be manipulated and analyzed. The isolation of the discretized volumes along with the device's inherent portability render our invention versatile for use in many areas, including but not limited to PCR, digital PCR, biological assays for diagnostics and prognostics, cancer diagnosis and prognosis, high throughput screening, single molecule and single cell reactions or assays, the study crystallization and other statistical processes, protein crystallization, drug screening, environmental testing, and the coupling to a wide range of analytical detection techniques for biomedical assays and measurements. The minimal fluid interconnects and simple flow geometry makes the device easy to use and implement, economical to fabricate and operate, and robust in its operations. | 2010-02-18 |
20100041047 | EFFICIENT REDUCTION OF TARGET RNA'S BY SINGLE- AND DOUBLE-STRANDED OLIGOMERIC COMPOUNDS - The present invention provides, inter alia, methods of selecting a single-stranded oligomeric compounds for inhibiting RNA expression, methods of generating double-stranded oligomeric compounds, methods of identifying optimized double-stranded oligomeric compounds, methods of selecting optimized single-stranded oligomeric compounds, methods of selecting optimized double-stranded oligomeric compounds, methods of identifying multifunctional oligomeric compounds, methods for optimizing target region selection for modulation of RNA expression, methods of optimizing expression modulation of RNA, and the like. The present invention further provides oligomeric compounds, 8-80 nucleobases in length targeted to a target RNA, wherein said oligomeric compound hybridizes to said target RNA and inhibits RNA levels by at least 50% in both single-stranded and double-stranded forms, and multifunctional oligomeric compounds. | 2010-02-18 |
20100041048 | Circulating Mutant DNA to Assess Tumor Dynamics - DNA containing somatic mutations is highly tumor specific and thus, in theory, can provide optimum markers. However, the number of circulating mutant gene fragments is small compared to the number of normal circulating DNA fragments, making it difficult to detect and quantify them with the sensitivity required for meaningful clinical use. We apply a highly sensitive approach to quantify circulating tumor DNA (ctDNA) in body samples of patients. Measurements of ctDNA can be used to reliably monitor tumor dynamics in subjects with cancer, especially those who are undergoing surgery or chemotherapy. This personalized genetic approach can be generally applied. | 2010-02-18 |
20100041049 | DETECTING NUCLEIC ACID - This document provides methods and materials for detecting target nucleic acid. For example, methods and materials for detecting the presence or absence of target nucleic acid, methods and materials for detecting the amount of target nucleic acid present within a sample, kits for detecting the presence or absence of target nucleic acid, kits for detecting the amount of target nucleic acid present within a sample, and methods for making such kits are provided. | 2010-02-18 |
20100041050 | Disposable Reactor Module and Detection System - A disposable reactor module, monitoring/optical detection system and related hardware for, inter alia, chemical reactions including Polymerase Chain Reactions. | 2010-02-18 |
20100041051 | Prostate Cancer Methylation Assay - An assay for diagnosing or prognosticating prostate cancer incorporates the detection of hypermethylation of SEQ ID NO 1, SEQ ID NO 3, and SEQ ID NO 2 genes and may be incorporated into a nomogram. | 2010-02-18 |
20100041052 | Receptor Tyrosine Kinase Assays - Methods for detecting phosphorylation of receptor tyrosine kinases (“RTKs”) upon activation are provided. The method employs cells comprising two fusion products: (1) an RTK fused to a small fragment of β-galactosidase and (2) a phosphotyrosine binding peptide fused to the large fragment of β-galactosidase, where the 2 fragments weakly complex to form an active enzyme, and optionally a construct for a cytosolic RTK phosphorylating kinase, when the RTK does not autophosphoryate. To detect phosphorylation a β-galactosidase substrate is added to the cells, whereby product formation indicates the occurrence of phosphorylation. | 2010-02-18 |
20100041053 | PROOFREADING PRIMER EXTENSION - The present invention provides for primer extension reactions, including polymerase chain reactions, in which a polymerase having 3′-5′ exonuclease activity edits a primer that is not fully complementary thereby allowing for amplification and detection of target nucleic acids that may have variability in their sequences. | 2010-02-18 |
20100041054 | METHODS FOR THE PRODUCTION OF IPS CELLS - Methods and composition of induction of pluripotent stem cells are disclosed. For example, in certain aspects methods for generating induced pluripotent stem cells using reporter genes are described. Furthermore, the invention provides novel reprogramming vectors employing reporter genes. | 2010-02-18 |
20100041055 | NOVEL GENE NORMALIZATION METHODS - Measurement of gene expression relative to an endogenous control gene is prone to excessive variability between samples and even replicates. The disclosure provides methods for normalizing expression levels of a gene by scaling gene expression levels to that of the most highly expressed gene in the set of genes whose expression levels are measured, rather than a house-keeping gene. | 2010-02-18 |
20100041056 | TEMPERATURE CONTROLLED NUCLEIC-ACID DETECTION METHOD SUITABLE FOR PRACTICE IN A CLOSED-SYSTEM - The invention relates to a method that utilizes thermophilic proteases for the treatment of nucleic acids in a closed-system to be used in tandem with methods for the rapid detection of target nucleic acids present in a sample. These combined methods enable simplified, temperature-controlled devices to be used for accurate, streamline testing at the point of care for a wide variety of applications in the medical, industrial, environmental, quality control, security and research fields. | 2010-02-18 |
20100041057 | DNA METHYLATION DETECTION METHODS - The present teachings provide DNA methylation quantification methods that avoid bisulfite treatment of DNA. Methylation-specific binding proteins (MeDNA binding proteins) and non-methylation specific binding proteins (non-MeDNA binding proteins) are employed in various embodiments to modulate the accessibility of nucleic acids to primer extension reactions. After selectively removing the target nucleic acids, the extension products can be analyzed and methylation quantitated. In some embodiments, the analysis comprises real-time PCR. | 2010-02-18 |
20100041058 | PIM-3 KINASE AS A TARGET FOR TYPE 2 DIABETES MELLITUS - The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus. | 2010-02-18 |
20100041059 | METHOD OF PREDICTING A BENEFIT OF ANTIOXIDANT THERAPY FOR PREVENTION OF CARDIOVASCULAR DISEASE IN HYPERGLYCEMIC PATIENTS - A method of determining a potential of a diabetic patient to benefit from anti oxidant therapy for treatment of a vascular complication, the method comprising determining a haptoglobin phenotype of the diabetic patient and thereby determining the potential of the diabetic patient to benefit from said anti oxidant therapy, whereby a patient having a haptoglobin 2-2 phenotype benefits from anti oxidant therapy more than a patient having a haptoglobin 1-2 phenotype or a patient having a haptoglobin 1-1 phenotype. | 2010-02-18 |
20100041060 | IRON-REGULATING PROTEIN-2(IRP-2) AS A DIAGNOSTIC FOR NEURODEGENERATIVE DISEASE - The present invention relates to the discovery of markers for neurodegenerative disease. More particularly, it was discovered that forms of IRP-2 protein that are unable to undergo oxidation at critical cysteine residues are diagnostic for neurodegenerative disease including, but not limited to Alzheimer's disease. Embodiments include nucleic acids that encode mutant IRP-2 proteins and fragments thereof, mutant IRP-2 proteins and fragments thereof, antibodies directed to epitopes present on mutant IRP-2 proteins and fragments thereof, methods of making these nucleic acids and polypeptides, as well as, approaches to diagnose neurodegenerative disease in animals, such as humans at risk of contracting Alzheimer's disease. | 2010-02-18 |
20100041061 | Enhancing Endotoxin Detection - Provided herein are methods for detecting gram negative bacteria or lipopolysaccharide in a sample. Kits for detecting gram negative bacteria or lipopolysaccharide in a sample are provided. | 2010-02-18 |
20100041062 | DEVICES, SYSTEMS, AND METHODS FOR AIDING IN THE DETECTION OF A PHYSIOLOGICAL ABNORMALITY - The present invention comprises a method for identifying the presence or absence of a pulmonary embolism using a combination of tests and brightline thresholds. The first test is a blood based test measuring D-Dimer concentration and the second test is a respiratory analysis that determines a carboximetry ratio. If the measured D-Dimer value is at or above a threshold indicative of concern and the carboximetry value is equal to or less than a carboximetry ratio threshold, pulmonary embolism is present. If the measured D-Dimer value is at or above a threshold indicative of concern and the respiratory analysis yields a carboximetry ratio greater than the carboximetry ratio threshold, test results are inconclusive and additional testing is required to determine whether a pulmonary embolism is present. | 2010-02-18 |
20100041063 | ANTI-DRUG ANTIBODY ASSAY - The invention provides an antibody binding specifically to Cynomolgus IgG characterized by not binding to Human IgG, and a method for the immunological determination of an immune complex (DA/ADA complex) of a drug antibody (DA) and an antibody against said drug antibody (anti-drug antibody, ADA) in a sample of a monkey species using a double antigen bridging immunoassay. | 2010-02-18 |