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07th week of 2011 patent applcation highlights part 36
Patent application numberTitlePublished
20110040030USE OF A CYCLOHEXANE DIOL MIXTURE FOR MANUFACTURING POLYMERS - A polymer obtainable by polycondensation or polyaddition from monomeric compounds, wherein one monomeric compound used is a mixture of hydroxymethylcyclohexanepropanol or its alkoxylated derivatives and hydroxymethylcyclohexaneisopropanol or its alkoxylated derivatives (referred to below for short as C1/C3 cyclohexanediol mixture).2011-02-17
20110040031INORGANIC NANOPARTICLES AND POLYMER COMPOSITE PRODUCED THEREFROM - The invention relates to metal oxide or semimetal oxide nanoparticles having an average particle size of from 2 to 250 nm, characterized in that the nanoparticles have at least two different, free-radically polymerizable groups on the surface. The invention further relates to nanocomposites produced from such nanoparticles and also processes for producing them.2011-02-17
20110040032ORGANOPOLYSILOXANE COMPOSITION ROOM TEMPERATURE VULCANIZABLE TO ELASTOMER AND NEW ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS - The present invention relates to an organopolysiloxane composition that can be vulcanized at room temperature into an elastomer that is crosslinked by polycondensation and that does not contain alkyltin-based catalysts and also to novel organopolysiloxane polycondensation catalysts.2011-02-17
20110040033ROOM TEMPERATURE VULCANISABLE ORGANOPOLYSILOXANE COMPOUND TO GIVE AN ELASTOMER AND NOVEL ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS - The present invention relates to an organopolysiloxane composition that can be vulcanized at room temperature into an elastomer that is crosslinked by polycondensation and that does not contain alkyltin-based catalysts and also to novel organopolysiloxane polycondensation catalysts.2011-02-17
20110040034ROOM-TEMPERATURE VULCANISABLE ORGANOPOLYSILOXANE COMPOUND TO GIVE AN ELASTOMER AND NOVEL ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS - The present invention relates to an organopolysiloxane composition that can be vulcanized at room temperature into an elastomer that is crosslinked by polycondensation and that does not contain alkyltin-based catalysts and also to novel organopolysiloxane polycondensation catalysts.2011-02-17
20110040035Low Gloss Mass Polymerized Rubber-Modified Monovinylidene Aromatic Copolymer Composition - Disclosed is a mass polymerized rubber-modified monovinylidene aromatic copolymer composition with an excellent balance of aesthetic, physical and mechanical properties, in particular good impact with low consistent gloss across an injection molded textured part, and a method for preparing such a composition.2011-02-17
20110040036METHOD FOR PRODUCING SILICONE POLYETHERS - Silicone polyethers are prepared in a two stage process by reacting an unsaturated polyether with a first Si—H functional organopolysiloxane and then with a second organopolysiloxane, in which the weight ratio of silicon bonded hydrogen in the first and second organopolysiloxanes is at least 0.9. The reaction is more rapid than a single step process and produces a product with less unreacted Si—H content.2011-02-17
20110040037RUBBER COMPOSITION AND USES THEREOF - It is an object of the present invention to provide a rubber composition having: excellent sealing properties, heat resistance and acid resistance; a low reaction force, low hardness and low compression set; and excellent low-temperature recovery properties that contribute to sealing properties particularly in low-temperature environment. It is another object of the invention to provide uses of the rubber composition and main bodies on which the rubber composition has been mounted. The rubber composition of the present invention comprises a specific ethylene/α-olefin/non-conjugated polyene copolymer [A], a SiH group-containing compound [B] having two SiH groups in one molecule, and a SiH group-containing compound [C] having three SiH groups in one molecule.2011-02-17
20110040038THERMOPLASTIC RESIN COMPOSITION - Disclosed is a thermoplastic resin composition comprising a cross-copolymer which meets specific requirements; and a polyphenylene ether resin, wherein the cross-copolymer is contained in an amount of 5 to 95 mass % and the polyphenylene ether resin is contained in an amount of 95 to 5 mass %. The thermoplastic resin composition has excellent heat resistant, excellent softness, excellent flexibility, excellent stretching properties, and excellent scratch-abrasion resistance.2011-02-17
20110040039TETRAFLUOROETHYLENE POLYMER PARTICLES - Core-shell particles having a core of at least one tetrafluoroethylene (TFE) polymer and having an average primary particle size of less than 50 nm; and a shell of at least one acrylic polymer having recurring units, more than 50% by moles of which being derived from at least one ethylenically unsaturated monomer having directly bonded to one of the sp2011-02-17
20110040040POLYMER MIXTURE - A nonwoven and a nonwoven fiber are disclosed. The fleece or fleece fiber include a polymer mixture. The polymer mixture includes a polyethyelene and a LLDPE. Various applications for the fleece are proposed.2011-02-17
20110040041Polymerization Processes Using Metallocene Catalysts, Their Polymer Products and End Uses - A process for the production of an ethylene alpha-olefin copolymer is disclosed, the process including polymerizing ethylene and at least one alpha-olefin by contacting the ethylene and the at least one alpha-olefin with a metallocene catalyst in at least one gas phase reactor at a reactor pressure of from 0.7 to 70 bar and a reactor temperature of from 20° C. to 150° C. to form an ethylene alpha-olefin copolymer. The resulting ethylene alpha-olefin copolymer may have a density D of 0.927 g/cc or less, a melt index (I2011-02-17
20110040042FUSED THIOPHENES, METHODS FOR MAKING FUSED THIOPHENES, AND USES THEREOF - Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereof.2011-02-17
20110040043NOVEL DIURETHANE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND ACRYLIC RUBBER COMPOSITION CONTAINING THE SAME - Disclosed is a diurethane compound R2011-02-17
20110040044SURFACE TREATMENT METHOD OF WATER-ABSORBING RESIN AND PRODUCTION METHOD OF WATER-ABSORBING RESIN - The present invention provides a surface treatment method for a water-absorbing resin comprising three steps of: 2011-02-17
20110040045REVERSIBLE DERIVATIZATION OF POLY (ARYL ETHER KETONES) - The embodiments of the present disclosure present systems and methods for the reversible solubilization of (aryl ether ketones) (PAEKs). A thioacetalization process is employed to modify the PAEKs into poly (aryl ether thioacetals) which, unlike PAEKs, are substantially soluble in common solvents. This modification allowing selected analysis techniques to be more easily performed on PAEKs1 such as gel permeation chromatography. The thioacetalization may be reversed through a deprotection reaction to recover the original PAEK without substantial degradation, allowing for non-destructive characterization of the PAEK. Advantageously, the thioacetalization process is generally applicable to a broad range of PAEKs, unlike presently known methods of solubilizing PAEKs. Solubilization of PAEKs further expands the utility of the PAEKs, opening up additional routes to chemical modification of PAEKs, as well as allowing for the possibility of processing PAEKs from solution.2011-02-17
20110040046ADDUCTS OF EPOXY RESINS AND PROCESS FOR PREPARING THE SAME - An adduct comprises at least one reaction product of (i) an epoxy resin material (A) and (ii) a reactive compound (B). The epoxy resin material (A) comprises a cis, trans-1,3- and -1,4-cyclohexanedimethylether moiety and the reactive compound (B) comprises a compound having two or more reactive hydrogen atoms per molecule, wherein the reactive hydrogen atoms are reactive with epoxide groups. A curable epoxy resin composition comprises the adduct described above. A cured epoxy resin is prepared by a process of curing the curable epoxy resin composition.2011-02-17
20110040047Elastomer and vulcanizate compositions having desirable high temperature properties - Compositions including a thermoplastic elastomer or thermoplastic vulcanizate derived from a styrenic block copolymer having a reactive or crosslinkable hard block including aromatic vinyl repeat units and also preferably a crosslinkable soft block, and a non-olefin thermoplastic polymer or copolymer and preferably a compatibilizer such as the reaction product of a non-olefin thermoplastic polymer and a functionalized polymer such as a maleic anhydride functionalized styrenic block copolymer that is compatible with the styrenic block copolymer having a reactive or crosslinkable hard block, and optionally a linking compound. The vulcanizates are prepared by crosslinking the styrenic block copolymer in the presence of the non-olefin thermoplastic polymer and a suitable crosslinking agent, and optionally the compatibilizer, preferably utilizing dynamic vulcanization. In a further embodiment, thermoplastic vulcanizate compositions are provided including the styrenic block copolymer, a polyolefin polymer or copolymer, a non-olefin thermoplastic polymer and the compatibilizer.2011-02-17
20110040048Method for Preventing Catalyst Agglomeration Based on Production Rate Changes - A system and method for olefin polymerization is provided. The method includes polymerizing one or more olefins within a reactor having one or more injection tubes in fluid communication therewith, at least one of the one or more injection tubes having two or more concentric flow paths; flowing a catalyst through a first flow concentric path of the injection tube into the reactor; flowing one or more monomers through a second concentric flow path of the injection tube into the reactor; measuring rate of heat removal within the reactor; and adjusting the one or more monomers flow through the injection tube in response to the rate of heat removal in the reactor.2011-02-17
20110040049TUBULAR FLOW REACTOR AND METHOD OF MANUFACTURING POLYMERIC RESIN FINE PARTICLE - In the present invention, a tubular flow reactor can maintain a plug flow property even though the tubular flow reactor is downsized, and provided is the tubular flow reactor with which uniform resin fine particles exhibiting a narrow particle size distribution and a narrow molecular weight distribution can be prepared when the tubular flow reactor is used for preparation of the resin fine particle via emulsion polymerization or the like. Disclosed is a tubular flow reactor possessing a stirring blade and a cylindrical channel, wherein a ratio d/D is 0.3-0.9 when a diameter of the stirring blade is represented by d and an inner diameter of the cylindrical channel is represented by D, and a ratio Lb/La is 0.80-0.99 when a length of the stirring blade is represented by Lb and a length of the cylindrical channel is represented by La.2011-02-17
20110040050PROCESS FOR PREPARING POLYACRYLATES - Use of amino acids as regulator substances in the free-radical polymerization of monomer mixtures comprising at least 70% by weight of at least one acrylic and/or methacrylic ester and reaction solution comprising one or more solvents and one or more monomers, at least 50% by weight of the solvents being organic solvents, and at least 70% by weight of the monomers being acrylic and/or methacrylic esters, with at least one amino acid is being present.2011-02-17
20110040051CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND A CATALYST COMPRISING THE SAME - A catalyst component for olefin polymerization comprising an α-cyanosuccinate compound as an internal electron donor, a catalyst comprising the catalyst component, and use of the catalyst in olefin polymerization. When used in propylene polymerization, the catalyst can exhibit good catalytic activity and good hydrogen response, and the resulting polymer can have a good isotacticity and a good molecular weight distribution.2011-02-17
20110040052Processes for Controlling the Viscosity of Polyalphaolefins - The invention relates to a process for forming a polyalphaolefin, the process comprising the step of polymerizing at least one C2011-02-17
20110040053POLYSILOXANE, ACRYLIC COMPOUND AND VINYLIC COMPOUND - A polysiloxane includes a structural unit in which a functional group represented by a general formula of2011-02-17
20110040054METHOD FOR PRODUCING POLYTETRAFLUOROETHYLENE FINE POWDER - To provide a method for producing a PTFE fine powder having a low paste extrusion pressure property by a simple method.2011-02-17
20110040055ELECTROCHROMIC CONJUGATED POLYMERS - A series of conjugated polymers with electrochromic properties and photovoltaic activity are provided. The representative structure formula of the conjugated polymers is shown as structure formula (I):2011-02-17
20110040056PROCESS FOR PRODUCTION OF POLYMER - Disclosed is a process for the production of a polymer by polymerizing a monomer or monomers in a solvent to give a polymer solution; and bringing the polymer solution into contact with a poor solvent to precipitate the polymer and to remove impurities therefrom, in which the polymer solution is diluted with a solvent before being brought into contact with the poor solvent to precipitate the polymer. The polymerization solvent preferably has a coefficient of viscosity at 20° C. of 1 mPa·s or more. The dilution solvent preferably has a coefficient of viscosity at 20° C. of less than 1 mPa·s. The process enables efficient production of a polymer with good reproducibility in quality, which polymer contains less amounts of residual monomers and is useful as resist polymers, polymers for undercoat films of multilayer resists, polymers for anti-reflection coatings, and polymers for immersion topcoats.2011-02-17
20110040057LIGAND-COUPLED INITIATOR POLYMERS AND METHODS OF USE - Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic β cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.2011-02-17
20110040058POLYMERIZATION OF ISOPRENE FROM RENEWABLE RESOURCES - The invention features compositions and methods for producing polymers of isoprene derived from renewable resources such as isoprene produced from cultured cells that use renewable carbon sources. A starting isoprene composition, such as a bioisoprene composition, is distinguished from petroleum based isoprene by the purity profile (such as lower levels of certain C5 hydrocarbons other than isoprene, presence of certain compounds associated with the biological process for production) and the relative content of the carbon isotopes. Polymers obtained by polymerization of such starting isoprene composition according to this invention, such as a polyisoprene homopolymer or a copolymer having repeat units that are derived from isoprene, are distinguishable from isoprene containing polymers from petrochemical resources. The present invention more specifically discloses a polyisoprene polymer which is comprised of repeat units that are derived from isoprene monomer, wherein the polyisoprene polymer has δ2011-02-17
20110040059ETHYLENE-a-OLEFIN COPOLYMER AND MOLDED ARTICLE - An ethylene-α-olefin copolymer wherein the copolymer has a monomer unit based on ethylene and a monomer unit based on an α-olefin having 3 to 20 carbon atoms, the density (d) is 860 to 950 kg/m2011-02-17
20110040060PROCESS FOR THE PRODUCTION OF POLYMER MICROPARTICLES - The object of the present invention is to provide a process for producing high-quality polymer microparticles having uniform particle size of the order of several micrometers to tens of micrometers by inverse suspension polymerization at high productivity while keeping excellent dispersion stability without causing aggregation among particles. The process is one for the production of polymer microparticles by inverse polymerization of a vinyl monomer and is characterized in that an oil-soluble oxidizing agent and a water-soluble reducing agent are used as a polymerization initiator and the oil-soluble oxidizing agent is fed after the water-soluble reducing agent is fed.2011-02-17
20110040061SHORT-CHAIN BRANCHED POLYPROPYLENE - A short-chain-branched polypropylene having xylene solubles of at least 0.5 percent by weight is provided. In certain embodiments the polypropylene has a strain hardening index of at least 0.15 as measured by a deformation rate of 1.00 s2011-02-17
20110040062COSMETIC PRODUCT - The present invention provides cosmetic products, such as makeup cosmetics and skin care cosmetics, which have a good water-proof and perspiration resistance and an excellent use feel such as spreadability at the time of application and long-wearing capabilities. Specifically, a cosmetic product containing a silicone resin, composed of (A) and (B) described below: 2011-02-17
20110040063PREPARATION OF TRIORGANOSILOXY END-CAPPED ORGANOPOLYSILOXANE - A triorganosiloxy end-capped organopolysiloxane, i.e., organopolysiloxane having a backbone consisting essentially of repeating (3,3,3-trifluoropropyl)methylsiloxane units and end-capped with triorganosiloxy groups is prepared by copolymerizing tris(3,3,3-trifluoropropyl)trimethylcyclo-trisiloxane with a silanol end-capped organopolysiloxane in the presence of an alkyllithium or lithium silanolate catalyst to form a silanol end-capped copolymer, and adding a trialkylsilyl triflate or strong acid in excess relative to the catalyst and a hexaorganodisilazane for effecting end-capping and neutralization.2011-02-17
20110040064THERMALLY-STABLE CROSSLINKED SILICONE ELASTOMERS - Thermally-stable silicone elastomers are prepared from organopolysiloxane compositions by polyaddition, polycondensation or vulcanization reactions in the presence of peroxide; the thermal stability of the silicone elastomers is achieved by the inclusion of an additive derived from an iron (III) complex.2011-02-17
20110040065POLYESTER RESIN, PRODUCTION PROCESS THEREFOR AND USE THEREOF - Polyester resins (C) of the invention have a practically sufficient high molecular weight and a high crystallinity and have an amide group in the molecular chain. Processes for producing the polyester resins are also disclosed. In detail, the polyester resins (C) have a practically sufficient high molecular weight and a high crystallinity and have a biodegradable amide group in the molecular chain. Processes for producing the polyester resins are also disclosed.2011-02-17
20110040066POLYCARBONATES HAVING REARRANGEMENT STRUCTURES, CYCLIC AND LINEAR OLIGOMERS AND ALSO FLOW BEHAVIOR - The present invention relates to compositions having improved rheological properties which are based on polycarbonate having rearrangement structures and cyclic and linear oligomers and also mouldings and extrudates composed of these polycarbonate compositions.2011-02-17
20110040067Low Melting Polyester Polymers - A bulk of polyester polymer particles comprising polyester polymer comprising greater than 75% virgin polyester polymer, the particles having: 2011-02-17
20110040068Method for forming organic layer pattern, organic layer pattern prepared by the same and organic memory devices comprising the pattern - Disclosed are a method for forming an organic layer pattern which is characterized by forming a thin layer by coating a coating solution including a polyimide-based polymer having a heteroaromatic pendant group including a heteroatom in its polyimide major chain, a photoinitiator and a crosslinking agent on a substrate and drying the substrate, and exposing and developing the thin layer, an organic layer pattern prepared by the method, and an organic memory device comprising the pattern. According to example embodiments, a high-resolution micropattern may be formed without undergoing any expensive process, e.g., photoresist, leading to simplification of the preparation process and cost reduction.2011-02-17
20110040069CONDENSED POLYCYCLIC COMPOUND, CONDENSED POLYCYCLIC POLYMER AND ORGANIC THIN FILM CONTAINING THE COMPOUND OR THE POLYMER - An object of the present invention is to provide a polycyclic fused ring polymer which has a structure capable of showing high charge transport properties and also is excellent in solubility into a solvent. The polycyclic fused ring polymer according to the present invention includes: a plurality of one of a first structural unit represented by the following formula (2011-02-17
20110040070ISOTACTIC POLY(ALKYLENE OXIDE) AND PRODUCTION PROCESS THEREOF - An isotactic poly(alkylene oxide) containing the defined repeating unit, and having an isotactic triad fraction of 66 to 100%, and number-average molecular weight of 500,000 or more; and a production process thereof, comprising the step of polymerizing an epoxide represented by the defined formula in the presence of a catalyst and an aliphatic compound and/or alicyclic compound.2011-02-17
20110040071Protein Kinase-Inducible Domains - Applicants have used protein design to develop novel functional protein architectures, termed protein kinase-inducible domains, whose structures are dependent on phosphorylation by specific protein kinases or are dependent on dephosphorylation by specific protein phosphatases. Applicants have designed kinase-inducible domains based on a modular architecture, which allows kinase-inducible domains to be responsive to any specific serine-threonine kinases. Kinase-inducible domains can consist of canonical amino acids, allowing their use as expressible tags of protein kinase activity.2011-02-17
20110040072MONO AND DI-SUBSTITUTED OXYCODONE COMPOUNDS AND COMPOSITIONS - The invention relates to pharmaceutical compounds and compositions comprised of a chemical moiety attached to oxycodone in a manner that substantially decreases the potential for overdose. When delivered at the proper dosage the pharmaceutical composition provides therapeutic activity similar to that of oxycodone and may also provide sustained release characteristics and/or reduced side-effects. Further the compounds and compositions of the invention are useful in preventing addiction and susceptibility to addiction of oxycodone.2011-02-17
20110040073Covalent Factor VII-Tissue Factor Complex - The present invention relates to novel covalent complexes of a Factor VII polypeptide and a Tissue Factor polypeptide, in particular to such complexes which are functionally active and which have an enhanced proteolytic activity towards Factor X compared to the corresponding free Factor VII polypeptide as well as methods for production of these novel complexes.2011-02-17
20110040074PRODUCTION METHODS - The present invention provides methods of reducing the levels of a titratable selectable pressure required, the number of amplification cycles, and the time taken to generate protein expressing cell lines by altering the codons of the desired open-reading-frames. Through the use of codon adaptation for this purpose the methods of the invention consistently provide sufficient yields in faster time frames saving many weeks in cell line development activities. Furthermore the methods of the invention also generate cell lines with lower concentrations of selection and amplification agent than previously achievable. Accordingly lower levels of selection and amplification marker in the final cells lines are observed.2011-02-17
20110040075ANTIBODY PURIFICATION BY PROTEIN A AND ION EXCHANGE CHROMATOGRAPHY - A novel method for selectively removing leaked protein A from antibody purified by means of protein A affinity chromatography is disclosed.2011-02-17
20110040076Human Anti-NGF Neutralizing Antibodies as Selective NGF Pathway Inhibitors - This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.2011-02-17
20110040077Protein-Responsive Translational Regulatory System Using RNA-Protein Interacting Motif - An object of the present invention is to provide a translationally regulatable mRNA which has wider application and can perform specific ON-OFF regulation, an RNA-protein complex specifically bound to the mRNA, and a translational regulatory system. The present invention provides an mRNA having an RNA-protein complex interacting motif-derived nucleotide sequence 5′ to the ribosome-binding site or within the 5′ region of the open reading frame, and an mRNA having a nucleotide sequence complementary to an RNA-protein complex interacting motif-derived nucleotide sequence 5′ to the ribosome-binding site or within the 5′ region of the open reading frame.2011-02-17
20110040078PROCESS FOR THE PRODUCTION OF TELITHROMYCIN - The present invention relates to a process for the preparation of erythromysin derivatives, in particular telithromycin of formula (I) and its pharmaceutically acceptable salts, providing the isolated intermediates in crystalline form of superior stability and purity.2011-02-17
20110040079Infectious cDNA Clone of North American Porcine reproductive and Respiratory Syndrome (PRRS) Virus and Uses Thereof - The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of North American PRRS virus. The invention also provides vaccines comprising genetically modified North American PRRS virus, RNA molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules. Also provided are isolated polynucleotide molecules further comprising at least one nucleotide sequence that encodes a detectable heterologous antigenic epitope, and vaccines comprising North American PRRS virus, RNA molecules, plasmids and viral vectors comprising such isolated polynucleotide molecules.2011-02-17
20110040080Infectious cDNA Clone of North American Porcine Reproductive and Respiratory Syndrome (PRRS) Virus and Uses Thereof - The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American PRRS virus. The invention also provides isolated polynucleotide molecules, infectious RNA molecules, viral vectors, and transfected host cells encoding genetically-modified North American PRRS viruses; and genetically-modified North American PRRS viruses encoded thereby. The invention also provides vaccines comprising such plasmids, RNA molecules, viral vectors, and North American PRRS viruses, and methods of using these vaccines in swine and in other animals. Also provided are isolated polynucleotide molecules, viral vectors, and transfected host cells that comprise a nucleotide sequence encoding a peptide of a North American PRRS virus. These viral vectors and transfected host cell lines are useful in providing peptides to compensate for mutated peptide coding sequences of DNA sequences encoding genetically-modified North American PRRS viruses so that functional virions can be generated.2011-02-17
20110040081METHODS, COMPOSITIONS, AND KITS FOR GENERATING rRNA-DEPLETED SAMPLES OR ISOLATING rRNA FROM SAMPLES - The present invention provides methods, compositions, and kits for generating rRNA-depleted samples and for isolating rRNA from samples. In particular, the present invention provides compositions comprising affinity-tagged antisense rRNA molecules corresponding to substantially all of at least one rRNA molecule (e.g., 28S, 26S, 25S, 18S, 5.8S and 5S eukaryotic cytoplasmic rRNA molecules, 12S and 16S eukaryotic mitochondrial rRNA molecules, and 23S, 16S and 5S prokaryotic rRNA molecules) and methods for using such compositions to generate rRNA-depleted samples or to isolate rRNA molecules from samples.2011-02-17
20110040082Modifications of antimetabolite gemcitabine for incorporation in CpG oligonucleotides - This Divisional application of patent application Ser. No. 10/768,996, entitled “Novel Oligonucleotides And Related Compounds” discloses a class of chemical compounds which have been demonstrated to possess cancer fighting properties. The parent application disclosed oligonucleotides for selectively killing cancerous cells over noncancerous cells by incorporating and covalently linking antimetabolite prodrugs via CpG moieties, for the anitmetabolite Gemcitabine and other compounds with known cancer fighting properties. This application discloses modifications of Gemcitabine for incorporation into CpG oligonucleotides for improved biochemical and biological properties.2011-02-17
20110040083PHOTORESPONSIVE NUCLEIC ACID MANUFACTURING METHOD - The present invention provides a manufacturing method that can easily manufacture a compound known as photoresponsive (photocoupling) nucleic acids at high yield in a shorter period of time than that of the conventional technology. The present invention relates to a method of manufacturing a photoresponsive nucleic acid which includes a step of reacting a nucleic acid having groups represented by the Formula I, the Formula III, the Formula IV, or the Formula V and a compound represented by the Formula II, or reacting a nucleic acid having groups represented by the Formula VI, the Formula VIII, the Formula IX, or the Formula X and a compound represented by the Formula VII by heating them by microwaves in the presence of a metal catalyst, a basic substance, and a solvent.2011-02-17
20110040084METHOD FOR EXTRACTING SIALIC ACID-CONTAINING COMPOUND FROM PLANT - It is an object of the present invention to provide an extraction method for a sialic acid-containing compound from a natural raw material, which has no risk of contamination with pathogens affecting animals, can achieve mass production, and does not require the use of an organic solvent harmful to the environment and human body. Provided is an extraction method for a water-soluble sialic acid-containing compound, the method comprising: crudely extracting a water-soluble component with water, polyol, or water containing either an acid or an alkali or polyol from a plant body or a processed product of the plant body, in particular, seeds of cereal or seeds of bean; and separating and recovering the water-soluble sialic acid-containing compound from the resultant crude extract solution with a column packed with a serotonin affinity support.2011-02-17
20110040085PROCESS TO PREPARE CROSSLINKED CELLULOSE ETHERS, CROSSLINKED CELLULOSE ETHERS OBTAINABLE BY SUCH PROCESS AND THE USE THEREOF - The invention relates to a dry or slurry process to prepare phosphate-crosslinked cellulose ethers from a cellulose starting material comprising the steps of adding an alkalizing agent to the cellulose starting material to achieve mercerization, adding an ethehfying agent to the reaction mixture to achieve etherification of the cellulose, and adding a crosslinking agent to the reaction mixture to achieve crosslinking of the cellulose, wherein at least part of the alkalizing agent is added to the cellulose starting material before the etherification and/or crosslinking reactions take place to obtain alkalized cellulose; the crosslinking agent and the etherifying agent are added one after the other in random order or simultaneously; the crosslinking agent is an alkali metal thmetaphosphate; and the crosslinking and etherification steps are performed at an elevated temperature. Additionally, the invention relates to crosslinked cellulose ethers obtainable by the above process having a viscosity and/or water absorption capacity higher than their non-crosslinked equivalents and the use thereof.2011-02-17
20110040086Novel Beta-Lactam Antibiotics, Methods for Their Production, and Their Use - The invention relates to novel antimicrobial agents that are based on β-lactam derivatives and are produced by reacting previously known β-lactam derivatives with polyphenol oxidase substrates under the influence of free radicals and by forming salts of any β-lactam derivatives with polyhexamethylene biguanide hydrogen carbonate. Said novel compounds are suitable as an antibiotic.2011-02-17
20110040087PEPTIDE TURN MIMETICS - Peptide mimetics of structure X herein which (i) provide a wide range of sidechain functions at all sidechain positions, (ii) can be incorporated in a peptide sequence, (iii) can be readily synthesized and (iv) have a variety of conformations. There is also provided a novel process which can provide valuable intermediates in relation to production of peptide mimetics of structure X which intermediates have a high degree of chemo- and stereo-selectivity. Preferred mimetics include structures I, II, III, IV, V and VI.2011-02-17
20110040088FUSED HETEROCYCLIC COMPOUNDS - Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.2011-02-17
20110040089PROCESS FOR PREPARING BENZOMORPHOLINE DERIVATIVES BY HYDROGENATING O-NITROPHENOXY CARBONYL COMPOUNDS - A process for preparing benzomorpholine derivatives is described, in which an o-nitrophenoxy carbonyl compound is hydrogenated in the presence of extraneous metal-doped sponge metal catalysts based on nickel or cobalt with ring formation.2011-02-17
20110040090PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES - The present invention relates to a process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamides and to the useful intermediate compounds of such process. 5-(2-Amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamides are described and claimed in W02007110344, which also discloses processes for their preparation. These compounds can be advantageously prepared through a process which allows to obtain the desired products in high yields and purity and with a limited number of steps. The synthesis is starting from a cyano pyrrole derivative, and is characterized from the final hydrolysis of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carbonitrile. The compounds prepared according to the process of the present invention are endowed with protein kinase inhibiting activity and, more particularly, Cdc7 or Cdc7/Cdks inhibiting activity. The compounds are therefore useful in the treatment of a variety of cancers, cell proliferative disorders and diseases associated with protein kinases.2011-02-17
20110040091PROCESS FOR THE PREPARATION OF (R)-2-PHENYL PROPIONIC ACID DERIVATIVES - The present invention relates to a process for the preparation of (R)-2-phenyl propionic acid derivatives of the formula2011-02-17
20110040092 PROCESS FOR MAKING AND USING HOF.RCN - The invention relates to a process for making HOF.RCN and using it to oxidise organic substrates in a quick and safe way. The process comprises passing diluted fluorine through a conduit and RCN in water through another conduit into a microreactor to form HOF.RCN and reacting this with an organic substrates.2011-02-17
20110040093PROCESS FOR THE PREPARATION OF PHARMACEUTICAL INTERMEDIATE - The invention relates to a process for the preparation of compounds of general formula (III), wherein R represents fluorine or chlorine atom and X represents chlorine or bromine atom, by halogenation of cyclopropyl benzyl ketone of general formula (II), wherein R represents fluorine or chlorine atom and the halogenation is carried out in the mixture of aqueous hydrogen halide and aqueous hydrogen peroxide in the presence of a water miscible solvent or in the presence of a phase transfer catalyst; or the halogenation is carried out in the mixture of sulfuric acid and an alkali metal salt of aqueous hydrogen halide. The process can be applied preferably on industrial scale.2011-02-17
201100400941,3,4-TRISUBSTITUTED BENZENES - Compounds that are 1,3,4-trisubstituted benzenes which modulate (e.g., inhibit) the activity of γ-secretase. The compounds are expected to reduce the level of Aβ42 in patients and be useful in the treatment of diseases (e.g., Alzheimer's disease) characterized by elevated levels of Aβ42 and/or the formation of Aβ plaques.2011-02-17
20110040095PREPARATION OF MONTELUKAST AND ITS SALTS - Processes for preparing montelukast acid and its salts.2011-02-17
20110040096Method for the Production of Halogen-Substituted 2-(aminomethylidene)-3-oxobutyric Acid Esters - The present invention relates to a process for preparing 2-(aminomethylidene)-4,4-dihalo-3-oxobutyric esters of the formula (I),2011-02-17
20110040097PROCESS FOR PREPARING LERCANIDIPINE HYDROCHLORIDE - Disclosed herein is a novel method for preparing lercanidipine hydrochloride which is highly effective for treating hypertension. The method comprises the steps of reacting 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid with a substituted chlorophosphate derivative to obtain a substituted phosphonoester derivative, and reacting the substituted phosphonoester derivative with 2, N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol. According to the preparation method, since little by-products are formed, the yield is improved, as compared to cases of conventional methods. In addition, the method involves simple isolation and purification processes of lercanidipine, thus realizing a high-quality product. Furthermore, the method has advantages of low preparation costs, substantial waste-free environmental-friendly process and applicability to industrial mass-production.2011-02-17
20110040098Organoactinide-, Organolanthanide-, and OrganoGroup-4-Mediated Hydrothiolation of Terminal Alkynes with Aliphatic, Aromatic and Benzylic Thiols - An efficient and highly Markovnikov selective organoactinide-, organolanthanide-, and organozirconium-catalyzed addition of aryl, benzyl, and aliphatic thiols to terminal alkynes is described. The corresponding vinyl sulfides are produced with little or no side-products.2011-02-17
20110040099METHOD FOR MANUFACTURING RUTHENIUM CARBENE COMPLEXES - A method of manufacturing ruthenium carbene complexes and novel aryl alkylidene ruthenium complexes based on the method, the complexes able to used as catalysts in metathesis reactions.2011-02-17
20110040100CRYSTALLINE FORMS OF 3-[5-(2-FLUOROPHENYL)-[1,2,4]OXADIAZOL-3-YL]-BENZOIC ACID - The present invention relates to crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid, pharmaceutical compositions and dosage forms comprising the crystalline forms, methods of making the crystalline forms and methods for their use for the treatment, prevention or management of diseases ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay.2011-02-17
20110040101ALANINE RACEMASE CHIRAL BINAPHTHOL DERIVATIVE WITH POWERFUL HYDROGEN BOND DONOR, AND OPTICAL RESOLUTION AND OPTICAL TRANSFORMATION METHODS USING THE SAME - Disclosed is an alanine racemase chiral binaphthol derivative having the ability to recognize amino alcohols selectively on the basis of chirality and transform amino acids from an L-form into a D-form. Methods for the optical resolution of amino acid or amino alcohol and for the optical transformation of D- and L-forms of amino acids using the binaphthol derivative are also provided.2011-02-17
20110040102PROCESS FOR THE PREPARATION OF INDAZOLYL UREAS THAT INHIBIT VANILLOID SUBTYPE 1 (VR1) RECEPTORS - The present invention relates to a process of preparing indazolyl ureas that are useful as antagonists of the vanilloid receptor subtype 1 (VR1).2011-02-17
20110040103PREPARATION OF PENTAFLUOROSULFANYL (SF5) HETEROCYCLES: PYRROLES AND THIOPHENES - The subject invention pertains to pentafluorosulfonyl (SF5) substituted pyrroles, thiophenes, 3-pyrrolines and 2,5-dihydrothiophenes, as well as methods for their synthesis.2011-02-17
20110040104ORGANOCATALYST - The present invention provides an organocatalyst of formula (I),2011-02-17
20110040105PROCESSES USEFUL FOR THE SYNTHESIS OF (R)-1--2-METHYL-PYRROLIDINE - Processes useful for making a pharmaceutically useful compound according to Formula (I), forms of such a compound, and intermediates useful in such processes are described.2011-02-17
20110040106ORGANIC SEMICONDUCTOR COMPOUND, SEMICONDUCTOR ELEMENT, SOLAR BATTERY, AND PROCESS FOR PRODUCING ORGANIC SEMICONDUCTOR COMPOUND - Disclosed is, for example, a compound that can be a material which can control many functions. According to a first aspect of the present invention, there is provided an organic semiconductor compound characterized in that the organic semiconductor compound is produced by forming a salt of organic molecules as a donor with an inorganic acid or an inorganic base and causes self-accumulation. According to the above constitution, the organic semiconductor compound can be obtained in a simple manner. According to a second aspect of the present invention, there is provided an organic compound characterized by being produced by deriving an ammonia salt or a hydroxyamine salt from a compound having a tetrathiafulvalene analogue site in the skeleton thereof and containing a protonic acid functional group. According to the above constitution, an organic compound which can control many functions can be obtained.2011-02-17
20110040107[1]BENZOTHIENO[3,2-B][1]BENZOTHIOPHENE COMPOUND AND METHOD FOR PRODUCING THE SAME, AND ORGANIC ELECTRONIC DEVICE USING THE SAME - A [1]benzothieno[3,2-b][1]benzothiophene compound expressed by General Formula (I): General Formula (I) where X and Y are each independently a hydrogen atom; a halogen atom; or a functional group having a straight or branched aliphatic alkyl group optionally having a halogen atom, a functional group having an alicyclic alkyl group optionally having a halogen atom, a functional group having a straight or branched aliphatic alkenyl group optionally having a halogen atom, a functional group having an alicyclic alkenyl group optionally having a halogen atom, a functional group having a carboxyl group, or a functional group having a thiol group, as a partial structure; and X and Y are the same or each independently different, provided that at least one of X and Y has a straight or branched aliphatic alkenyl group, an alicyclic alkenyl group, a carboxyl group or a thiol group, as a partial structure.2011-02-17
20110040108INOSITOLPHOSPHOLIPIDS AND ANALOGUES PHOSPHATIDYLINOSITOL PRODUCTS AND PROCESSES - Embodiments of the invention relate to natural and synthetic inositolphospholipid (IPL) materials, their preparation and applications. They provide compositions of the parent IPL comprising phosphatidylinositol (PI), PI-phosphates (phosphoinositides) and derivatives and analogues, and a process for their production starting from natural IPL. The embodiments further provide functional derivatives of PI for biomedical applications including a platform for drug design and delivery to therapeutic targets in the phosphoinositide mediated cellular signaling and allied cascades. The embodiments pertain to IPL having absolute stereo-structure. The embodiments further pertain to unique IPL and PI product compositions for defined applications, particularly pharmaceutical compositions for prophylaxis and treatment of diseases related to aberrant cellular and nuclear signaling mediated by PI and PI derived phosphates, and associated phosphoinositide specific enzymes including PI-PLC and PI 3-kinase.2011-02-17
20110040109METHOD OF CARBON CHAIN EXTENSION USING NOVEL ALDOL REACTION - Method of producing C2011-02-17
20110040110METHOD OF CARBON CHAIN EXTENSION USING NOVEL ALDOL REACTION - Method of producing C2011-02-17
20110040111EPOXY COMPOUND AND MANUFACTURING METHOD THEREOF - A novel epoxy compound represented by the following formula and a method for producing the same are provided:2011-02-17
20110040112METHOD FOR MAKING 3A-HYDROXY, 3B- SUBSTITUTED-5A-PREGNAN-20-ONES - Applicants have discovered a method for the stereoselective and regioselective synthesis of 3α-hydroxy, 3β-methyl-5α-pregnan-20-one (ganaxolone) comprising reacting 5α-pregnane-3,20-dione; with an organometallic methylating agent in an inert solvent to provide a compound of the formula2011-02-17
20110040113Pure PEG-lipid conjugates - Syntheses of polyethyleneglycol (PEG)-lipid conjugates are disclosed. Such syntheses involve stepwise addition of small PEG oligomers to a glycerol backbone until the desired chain size is attained. Polymers resulting from the syntheses are highly monodisperse. The present invention provides several advantages such as simplified synthesis, high product yield and low cost for starting materials. The present synthesis method is suitable for preparing a wide range of conjugates.2011-02-17
20110040114METHOD OF MANUFACTURING AN AMINOARYL-CONTAINING ORGANOSILICON COMPOUND AND METHOD OF MANUFACTURING AN INTERMEDIATE PRODUCT OF THE AFOREMENTIONED COMPOUND - To provide an aminoaryl-containing organosilicon compound with high efficiency, after protecting amino groups of a haloaniline compound with a specific compound, to form a Grignard reagent and to deprotect the aforementioned groups by reacting the Grignard reagent with a silicon compound.2011-02-17
20110040115INTERMEDIATES AND PROCESS FOR THE PREPARATION OF AROMATIC DERIVATIVES OF 1-ADAMANTANE - Process for the preparation of aromatic derivatives of 1-adamantane (tricyclo[3.3.1.1 (3,7)]decane), or an acceptable pharmaceutical salt thereof, based on a hydrolysis reaction of a precursor cyano compound. It also comprises different processes for obtaining the cyano compound. It is especially useful for obtaining Adapalene on an industrial scale in high yield and purity. It also comprises new intermediates useful in said preparation process.2011-02-17
20110040116Method For Producing Alkoxylated Phosphoric Acid Triesters - The invention relates to a method for producing phosphoric acid triesters of formula (I). According to said method, phosphoric acid or a phosphoric acid derivative selected from orthophosphoric acid, tetraphosphoric decaoxide and polyphosphoric acid is reacted with alkoxylated alcohols of formulae (II) R2011-02-17
20110040117PROCESS FOR PREPARING DIALKYL CARBONATES FROM ALKYLENE CARBONATES AND ALCOHOLS - The present invention relates to a continuous process for preparing lower dialkyl carbonates as main product and alkylene glycol as by-product by catalyzed transesterification of a cyclic alkylene carbonate (e.g. ethylene carbonate or propylene carbonate) with lower alcohols, where the reaction of the alkylene carbonate is carried out with an alcohol containing dialkyl carbonate in countercurrent, characterized in that introduction of a stream containing at least 99.5% by weight of alcohol takes place below the point of introduction for the alcohol containing dialkyl carbonate in a particular spacing ratio between the abovementioned points of introduction.2011-02-17
20110040118FLUORINE-CONTAINING BORONIC ACID ESTER COMPOUND AND METHOD FOR PRODUCING THE SAME - A fluorine-containing boronic acid ester compound2011-02-17
20110040119METHOD FOR PREPARING PRECURSOR OF RADIOACTIVE 3-IODOBENZYLGUANIDINE - A method for preparing a precursor of radioactive 3-iodobenzylguanidine-N,N′-bis(tert-butyloxycarbonyl)-3-(tri-n-butyltin)benzylguanidine) (MSnBG) is revealed. The MSnBG is a precursor of [*I]MIBG that is used as radioactive imaging agents and antineoplastic drugs. The method includes following steps. Firstly, obtain 3-iodobenzylguanidine bicarbonate by an addition reaction between 3-iodobenzylamine hydrochloride and cyanamide. Use di-tert-butyl dicarbonate as a protecting agent for NH group and convert 3-iodobenzylguanidine bicarbonate into N,N′-bis(tert-butyloxycarbonyl)-N-(3-iodobenzyl) guanidine. At last, under catalysis of bis(triphenylphosphine) palladium dichloride, obtain a final product MSnBG by a substitution reaction between N,N′-bis(tert-butyloxycarbonyl)-N-(3-iodobenzyl) guanidine and bis(tri-n-butyltin). MSnBG is used in no-carrier-added synthesis of [*I]MIBG. The [*I]MIBG obtained by this method has better effect on neuroblastoma treatment than that obtained by conventional, carrier-added method.2011-02-17
20110040120PREPARATION OF OSELTAMIVIR PHOSPHATE (TAMIFLU.RTM.) AND INTERMEDIATES STARTING FROM D-GLUCOSE OR D-XYLOSE - Novel processes for the preparation of the anti-viral agent, Oseltamivir Phosphate and novel intermediates prepared in such processes. The novel processes use as starting materials D-glucose or D-xylose in the preparation of Oseltamivir Phosphate.2011-02-17
20110040121Process for producing purified terephthalic acid - Disclosed is a process for producing purified terephthalic acid, which employs new para-xylene (PX) oxidation technology to make the intermediate product, crude terephthalic acid (CTA) produced by oxidation does not contain two purities of 4-carboxybenzaldehyde (4-CBA) and para-toluic acid (PT acid), so that the factory processing operation of “purification” can be omitted. PTA product produced by the present process is more suitable to be used as the polymer raw material of food packaging material, beverage bottle material, medicament packaging material and medical appliance since the content of formaldehyde group thereof is extremely low and it has the advantages of being safer and having no poison.2011-02-17
20110040122METHOD FOR PREPARING METAL SALT OF VALPROIC ACID - The present invention provides a simple, safe and more efficient process for preparing metal salts of valproic acid. The process includes steps of: (i) mixing valproic acid and a metal hydroxide (either dry solid or aqueous solution) in a drier to form a reaction mixture; and (ii) removing water, which is produced during the step of mixing the valproic acid and the metal hydroxide, from the reaction mixture to obtain the desired metal salts of valproic acid.2011-02-17
20110040123Bifunctional compound containing amino group and diaminedithiol ligand and manufacturing method thereof - A bifunctional compound containing an amino group and diaminedithiol ligand and a manufacturing method thereof are revealed, the bifunctional compound includes at least one amino group and a diaminedithiol (N2011-02-17
20110040124Method for Preparing Metal Complexes of Polydentate Beta-Ketoiminates - A method for making a group 2 metal-containing polydentate β-ketoiminate represented by the following structure A:2011-02-17
20110040125NITROGEN AND HINDERED PHENOL CONTAINING DUAL FUNCTIONAL MACROMOLECULAR ANTIOXIDANTS: SYNTHESIS, PERFORMANCES AND APPLICATIONS - Disclosed are compounds represented by structural formula (I):2011-02-17
20110040126NOVEL MERCAPTAN-BASED CORROSION INHIBITORS - Corrosion of both ferrous and non-ferrous metals, induced by a variety of corrosive aqueous-based environments, may be inhibited or controlled through use of corrosion inhibiting compositions comprising at least one member of certain formula-specified categories of mercaptan-based compounds. Where the compounds are appropriately selected, and particularly at low inhibitor concentrations, the compositions may inhibit corrosion to a degree that is comparable to or significantly greater than the inhibition provided by an equal amount of certain other corrosion inhibitor compounds. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.2011-02-17
20110040127PROCESS FOR PRODUCING A 2-ALKYL-2-CYCLOALKEN-1-ONE - The present invention relates to a process for producing a 2-alkyl-2-cycloalken-1-one represented by the following general formula (2), including the step of reacting a 2-alkylidene cycloalkanone in the presence of a palladium and/or platinum catalyst which is treated in the following steps (a) and (b); and a method for activating the palladium and/or platinum catalyst including the following steps (a) and (b): 2011-02-17
20110040128OPTIMIZED PRODUCTION OF KETONES/ALDEHYDES - Production of a ketone or aldehyde prepared by condensation is optimized by dehydration and hydrogenation of a starting acetone/ketone or aldehyde in a reaction zone and wherein water is partially eliminated from such reaction product by at least one membrane pervaporation module, the pervaporation module being fed tangentially and situated laterally to the reaction zone and operating in a loop, and wherein a fraction of reaction product exiting the reaction zone is thus partially dehydrated and recycling such dehydrated concentrate to the reaction zone.2011-02-17
20110040129PROCESS FOR THE PRODUCTION OF DIMETHYL ETHER - A process for the production of dimethyl ether from a methanol reactor effluent is disclosed. The process may include: contacting an aqueous extractant comprising water and an effluent from a methanol synthesis reactor comprising methanol and one or more of methane, water, carbon monoxide, carbon dioxide, hydrogen, and nitrogen. At least a portion of the methanol partitions into the aqueous extractant; recovering an extract fraction comprising the aqueous extractant and methanol. The extract fraction is fed to a catalytic distillation reactor system for concurrently: contacting the methanol with catalyst in a reaction zone thereby catalytically reacting at least a portion of the methanol to form dimethyl ether and water; and fractionating the resulting dimethyl ether and the water to recover a first overheads fraction comprising dimethyl ether and a first bottoms fraction comprising water.2011-02-17