07th week of 2012 patent applcation highlights part 43 |
Patent application number | Title | Published |
20120040822 | Non-destructive process for the elimination of silicon from alumina based materials - The present invention refers to a method for eliminating silicon or silicon compounds that are contained in alumina based materials without destroying such alumina based materials allowing for their reutilization, its main application is being the regeneration of alumina based catalyst contaminated with silicon, which are used in hydro-treating processes in the oil industry for sulfur elimination and silicon removal from process streams. It is important to note that the procedures and/or conventional methods known so far for the elimination and removal of silicon contained in alumina based materials, use inorganic acids or their mixture in a digestion process which modifies the properties of alumina and of any other element contained in the material, thus destroying the alumina and disabling their reutilization. The non-destructive method of the present invention is characterized by the fact that an extraction agent depolymerize the silicon compounds deposited in alumina based materials, with no modification of the properties of the alumina based material and with no substantial modification of other materials o or on the metal content present in the alumina based material. The extraction agent used is an alcohol, preferably a polyol and more preferably glycerol, which is available needless of high grade of purity for its use. The silicon contained in alumina based materials, in which the non-destructive method of the present invention is used, is preferably found in inorganic structures such as oxide or silanol: Si—(OX) | 2012-02-16 |
20120040823 | METHOD FOR PRODUCING CATALYST FOR USE IN PREFERENTIAL OXIDATION REACTION OF CARBON MONOXIDE - The present invention provides a method for producing a catalyst for use in preferential carbon monoxide oxidation, which catalyst has a high preferential carbon monoxide oxidation activity and a high methanation activity with respect to the carbon monoxide contained in hydrogen gas, can thus stably reduce the carbon monoxide concentration to an extremely lower level and comprises porous inorganic oxide support particles and, on the basis of the mass thereof, 0.01 to 10 percent by mass of ruthenium and 0.01 to 1 percent by mass of platinum, loaded on the support. The method comprises (1) a step of loading 30 to 70 percent of the total amount of ruthenium to be loaded, on the support particles by a competitive adsorption method and (2) a step of loading the rest of the total amount of ruthenium to be loaded and the total amount of platinum to be loaded, on the ruthenium-loaded support particles produced in step (1) without using a competitive adsorption agent. | 2012-02-16 |
20120040824 | EXHAUST GAS-PURIFYING CATALYST - An exhaust gas-purifying catalyst includes a support provided with one or more through-holes through which exhaust gas flows, and a catalytic layer supported by the support and containing an oxygen storage material. The exhaust gas-purifying catalyst includes a first section to which the exhaust gas is supplied, and a second section to which the exhaust gas having passed through the first section is supplied. The catalytic layer includes a layered structure of a first catalytic layer containing platinum and/or palladium and a second catalytic layer containing rhodium in the first catalytic section and further includes a third layer containing rhodium in the second section. The second section is smaller in oxygen storage material content per unit volumetric capacity than the first section. | 2012-02-16 |
20120040825 | Hydrogen Storage Material and Method for Producing the Same - A mixed powder of AlH | 2012-02-16 |
20120040826 | NOVEL HERBICIDES - Bicyclic dione compounds, and derivatives thereof, which are suitable for use as herbicides. | 2012-02-16 |
20120040827 | DISPERSANTS FOR AGRICULTURAL APPLICATIONS - An agrochemical formulation and its method of manufacture comprising an agrochemical active and a dispersant polymer comprising a copolymer of benzylmethacrylate, acrylic acid and 2-acrylamido-2-methyl propane sulfonic acid. | 2012-02-16 |
20120040828 | METHOD TO IMPROVE PHOSPHATE SOLUBILIZATION IN PLANTS - The present invention relates to the use of a bacterium having an high indole-3-acetic acid (IAA) content for solubilizing phosphate rock (PR) in the ground, wherein said bacterium is obtained by transformation with a gene encoding an agent able to increase the IAA content. | 2012-02-16 |
20120040829 | BACTERIAL GHOSTS AS CARRIER AND TARGETING VEHICLES - The invention concerns the use of bacterial ghosts as carrier and targeting vehicles for active substances. | 2012-02-16 |
20120040830 | HERBICIDAL FORMULATIONS COMPRISING GLYPHOSATE AND ALKOXYLATED GLYCERIDES - The present invention generally relates to herbicidal compositions, and more particularly, herbicidal compositions containing glyphosate or a salt thereof and a surfactant comprising at least one mono and/or diglyceride alkoxylate. | 2012-02-16 |
20120040831 | NITROGEN CONTAINING ISETHIONIC ACID SALTS IN FIELD READY SPRAY AND TANK MIXES - Embodiments of the present invention disclose an agricultural composition that is a field ready spray or a tank mix that includes at least one nitrogen containing isethionic acid salt, at least one agriculturally active ingredient, and at least one surfactant. | 2012-02-16 |
20120040832 | HERBICIDAL COMPOSITION COMPRISING AN AMINOPHOSPHATE OR AMINOPHOSPHONATE SALT AND AN N-ALKYL-PYRROLIDONE SOLVENT - The present invention relates to herbicidal compositions comprising an aminophosphate or aminophosphonate salt, for example to herbicidal compositions comprising an aminophosphate or aminophosphonate potassium salt. Preferred compositions of the invention have a high amount and the aminophosphate or aminophosphonate salt. The invention also relates to compositions of matter (or blend) that are especially useful ingredients for preparing the compositions comprising the aminophosphate or aminophosphonate salt. In particular, these ingredients are a surfactant such as an amine oxide surfactant, and an organic solvent comprising an N-alkylpyrrolidone wherein the alkyl group comprises at least 2 carbon atoms. | 2012-02-16 |
20120040833 | Agricultural pesticide compositions - A pesticide composition contains, based on 100 parts by weight (“pbw”) of the composition: (a) from about 15 to about 65 pbw of one or more pesticide compounds, (b) from greater than 0 to about 10 pbw of one or more fatty acid (C | 2012-02-16 |
20120040834 | Surfactants in Agrochemical Formulations - Surfactant compounds which include an amine ended polyalkylene glycol hydrophile linked to C | 2012-02-16 |
20120040835 | Method for Improved Use of the Production Potential of Genetically Modified Plants - The invention relates to a method for improving the utilization of the production potential of a genetically modified plant where the plant is treated with an effective amount of at least one compound of the formula (I) | 2012-02-16 |
20120040836 | COMPOSITIONS AND METHOD FOR BLOCKING ETHYLENE RESPONSE IN FIELD CROPS USING 3-(CY-CLOPROPYL-L-ENYL)-PROPANOIC SALT - A method of inhibiting an ethylene response in a field crop is disclosed, comprising the step of applying to at least one portion of at least one plant of said field crop an amount of a solution of a water soluble cyclopropyl-1-enyl-propanoic acid salt (WS-CPD, Formula I) effective to produce inhibition of an ethylene response in said at least one plant, wherein M is chosen from the group consisting of Na, Li, K, and ½Ca. | 2012-02-16 |
20120040837 | INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES - (1,3,5)-Triazinyl phenyl hydrazones are effective at controlling insects. | 2012-02-16 |
20120040838 | COIL WITH SUPERCONDUCTIVE WINDINGS COOLED WITHOUT CRYOGENIC FLUIDS - A coil comprises a set of windings with a generally annular shape and formed by a plurality of series-connected partial windings made of a superconductor with a high critical temperature, in which these partial windings are arranged next to each other in stratified form, and at least one cooling sheet which is made of thermally conductive material and arranged in contact with this set of windings and which is designed to be connected in a thermally conductive manner to a cryogenic cooling system. | 2012-02-16 |
20120040839 | Fault Current Limiter - A fault current limiter (FCL) includes a series of high permeability posts for collectively define a core for the FCL. A DC coil, for the purposes of saturating a portion of the high permeability posts, surrounds the complete structure outside of an enclosure in the form of a vessel. The vessel contains a dielectric insulation medium. AC coils, for transporting AC current, are wound on insulating formers and electrically interconnected to each other in a manner such that the senses of the magnetic field produced by each AC coil in the corresponding high permeability core are opposing. There are insulation barriers between phases to improve dielectric withstand properties of the dielectric medium. | 2012-02-16 |
20120040840 | METHOD FOR PRODUCING METAL LAMINATED SUBSTRATE FOR OXIDE SUPERCONDUCTING WIRE, AND OXIDE SUPERCONDUCTING WIRE USING THE SUBSTRATE | 2012-02-16 |
20120040841 | SUPERCONDUCTIVE ELECTRIC CABLE - The invention relates to a superconductive electric cable (SK) that has at least one superconductive conductor ( | 2012-02-16 |
20120040842 | Gene Expression Markers for Prediction of Patient Response to Chemotherapy - The present invention relates to gene sets useful in assessing prognosis and/or predicting the response of cancer, e.g. colorectal cancer to chemotherapy. In addition, the invention relates to a clinically validated cancer test, e.g. colorectal test, for assessment of prognosis and/or prediction of patient response to chemotherapy, using expression analysis. The present invention accommodates the use of archived paraffin embedded biopsy material for assay of all markers in the relevant gene sets and therefore is compatible with the most widely available type of biopsy material. | 2012-02-16 |
20120040843 | CENTRIFUGAL CAPTURE SYSTEM - A particle capture system that can be used in the context of a lab-on-a-chip platform for particle- and cell-based assays is described. The system comprises a capture chamber comprising a plurality of capture sites, the capture sites defining a capture area configured to receive individual particles travelling within the capture chamber. By rotating the chamber, the individual particles are biased towards the capture sites where they may be captured. | 2012-02-16 |
20120040844 | Methods and Apparatus for Measuring Analytes Using Large Scale FET Arrays - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis. | 2012-02-16 |
20120040845 | ADVANCED PATHOGEN TESTING AND CARCASS-CERTIFICATION METHODS FOR SLAUGHTER OPERATIONS - The invention provides methods for certification of carcasses, and for detecting a contaminated carcass and preventing its movement into or across a production area. The inventive methods comprise obtaining, early in the production process (pre-fabrication), a test sample from at least one test location of at least one split-portion of each carcass, wherein the test samples are obtained prior to or during chilling of the respective split portions, before entry thereof in the production chain. Composite test samples are assayed for pathogens or microbes, whereby certification is afforded, or whereby entry of the chilled split-carcass-Lot into the production area is precluded if the corresponding composite-Lot test sample is contaminated. Methods for remedial reconditioning of contaminated split-carcasses are provided, wherein essentially 100% of the carcasses are targeted to the production line. The inventive methods provide substantial public health benefit, and are efficient and economical to implement. | 2012-02-16 |
20120040846 | Methods of Detecting Diseases or Conditions Using Phagocytic Cells - This invention provides methods of using phagocytic cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also provides methods of using phagocytic cells to identify markers of diseases or conditions. | 2012-02-16 |
20120040847 | Personal Diabetic Carbohydrate Counting Procedure System and Method - A program interface for diabetic users to streamline the process of carbohydrate counting of meals. The present invention helps diabetic patients keep track of their blood glucose levels and help the users to calculate their require insulin intake for each meal. The invention comprises of a database of foods which users can select from for the calculation of nutrition and carbohydrates. The users are able to select their assigned carbohydrate to insulin ratio for the calculation of the amount of insulin that is required for the meal. Essential data is then stored and accessible for future corrective analysis. | 2012-02-16 |
20120040848 | MOLECULAR SIGNATURE OF LIVER TUMOR GRADE AND USE TO EVALUATE PROGNOSIS AND THERAPEUTIC REGIMEN - The present invention concerns a method to determine the gene expression profile on a sample previously obtained from a patient diagnosed for a liver tumor, comprising assaying the expression of a set of genes in this sample and determining the gene expression profile (signature). In a particular embodiment, said method enables to determine the grade of liver tumor, such as hepatoblastoma (HB) or a hepatocellular carcinoma (HCC). The invention is also directed to kits comprising a plurality of pairs of primers or a plurality of probes specific for a set of genes, as well as to solid support or composition comprising a set of probes specific for a set of genes. These methods are useful to determine the grade of a liver tumor in sample obtained from a patient, to determine the risk of developing metastasis and/or to define the therapeutic regimen to apply to a patient. | 2012-02-16 |
20120040849 | GENE EXPRESSION PROFILE AS AN ENDOMETRIAL RECEPTIVITY MARKER - The present invention relates to determining the receptivity of human endometrium from a gene expression profile. More specifically, the invention consists of developing a specific expression microarray of endometrial receptivity (Endometrial Receptivity Array or ERA) which allows evaluating the receptive state of a human endometrium, as well as assessing said state for diagnostic and therapeutic purposes. | 2012-02-16 |
20120040850 | Methods for Diagnosis and Assessment of Autoimmune Disorders - The present invention relates to methods and compositions for use in the diagnosis, assessment and treatment of patients with suspected autoimmune disorders. In particular, the present invention provides an auto-antibody assessment system that combines a multiplex bead array using purified antigens with human cells. When analysis is performed with the system using means such as flow cytometry, this mixture can provide a more comprehensive auto-antigen profile for assessing disease states in autoimmune disorders. | 2012-02-16 |
20120040851 | miRNA TARGETS - The present invention provides systems for identifying, isolating, and/or characterizing targets of micro RNAs. | 2012-02-16 |
20120040852 | BIOMARKERS - The present invention relates to a method of diagnosing or monitoring schizophrenia or other psychotic disorders | 2012-02-16 |
20120040853 | REAL TIME MULTIPLEX PCR DETECTION ON SOLID SURFACES USING DOUBLE STRANDED NUCLEIC ACID SPECIFIC DYES - The present invention provides method allowing for real time detection of a multitude of target nucleic acids of interest in one reaction (multiplexing) using dyes that are specific for double stranded nucleic acids. | 2012-02-16 |
20120040854 | Method for in vitro diagnosis or prognosis of testicular cancer - The invention relates to a method for in vitro diagnosis or prognosis of testicular cancer which comprises a step of detecting the presence or absence of at least one expression product from at least one nucleic acid sequence selected from the sequences identified in SEQ ID NOS: 1 to 6 or from the sequences which exhibit at least 99% identity with one of the sequences identified in SEQ ID NOS: 1 to 6, to isolated nucleic acid sequences and to the use thereof as a testicular cancer marker. | 2012-02-16 |
20120040855 | TISSUE-SPECIFIC AGING BIOMARKERS - The invention provides methods of developing tissue-specific biomarkers of aging, sets of robust biomarkers identified by those methods, and uses of the biomarkers to identify nutrients and other functional ingredients or agents having anti-aging properties. | 2012-02-16 |
20120040856 | METHOD FOR DETECTING THE PRESENCE OF LIQUIDS IN A MICROFLUIDIC DEVICE, DETECTING APPARATUS AND CORRESPONDING MICROFLUIDIC DEVICE - A method for detecting the presence of liquids includes detecting an initial temperature in a channel accommodating a liquid; heating the channel for a pre-determined test time; detecting a test temperature; determining a temperature variation on the basis of the initial temperature, the test temperature, and the test time; and comparing the temperature variation with at least one threshold. Before detecting an initial temperature, an ambient temperature is read, the channel is heated to the initial temperature, and is kept at the initial temperature for a time period. | 2012-02-16 |
20120040857 | ISOLATION OF FACTORS THAT ASSOCIATE DIRECTLY OR INDIRECTLY WITH CHROMATIN - Methods for isolating non-coding nucleic acids that are associated with chromatin at a target genomic locus are provided. The methods comprise the steps of obtaining a sample that comprises a target genomic DNA sequence and one or more non-coding nucleic acids associated with that DNA sequence; contacting the sample with at least one oligonucleotide probe that comprises a sequence that is complimentary to and capable of hybridising with at least a portion of the target DNA sequence, wherein the oligonucleotide probe comprises at least one modified nucleotide analogue and wherein the oligonucleotide probe further comprises at least one affinity label; allowing the at least one oligonucleotide probe and the target DNA sequence to hybridise with each other so as to form a probe-target hybrid; isolating the probe-target hybrid from the sample by immobilizing the probe-target hybrid through a molecule that binds to the at least one affinity label; and eluting the one or more non-coding nucleic acids that are associated with the target genomic DNA sequence. Also provided are probes suitable for use in the methods of the invention. The methods and probes of the invention are suited to identification of non-coding RNAs including microRNAs and snoRNAs that are associated with chromatin remodelling. | 2012-02-16 |
20120040858 | BIOMARKERS FOR STROKE - Biomarkers for stroke and methods for their detection are disclosed. In one aspect, the present application discloses biomarkers for the diagnosis of stroke in a subject. In another aspect, the application discloses a method for the diagnosis of stroke in a subject. The method comprises detection of stroke biomarkers in cerebrospinal fluid, blood, serum or PMBCs of a subject. Also disclosed is a kit for the detection of biomarkers for the diagnosis of stroke in a subject. | 2012-02-16 |
20120040859 | ASSAY SYSTEMS FOR GENETIC ANALYSIS - The present invention provides assays systems and methods for detection of chromosomal abnormalities and status of single loci associated with monogenic or polygenic traits in a sample containing nucleic acids from a maternal and a fetal source. | 2012-02-16 |
20120040860 | Methods for Determining Protein Binding Specificity Using Peptide Libraries - A method for determining protein binding specificity using a screen of a peptide library is provided. The method can be used to determine binding specificity for human NAD | 2012-02-16 |
20120040861 | Pancreatic Cancer Biomarkers and Uses Thereof - The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and pancreatic cancer specifically. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer generally or pancreatic cancer specifically. In another aspect, methods are provided for diagnosing pancreatic cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having pancreatic cancer, or the likelihood of the individual having pancreatic cancer is determined, based on the at least one biomarker value. In a further aspect, methods are provided for diagnosing cancer generally in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 19, wherein the individual is classified as having cancer generally, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value. | 2012-02-16 |
20120040862 | METHOD FOR DETECTING AND QUANTIFYING ENDOGENOUS WHEAT DNA SEQUENCE - A circular DNA is provided comprising endogenous DNA common to both genetically modified wheat and non-genetically modified wheat along with one or more pieces of DNA each having a sequence present specifically in a strain of genetically modified wheat. Also provided is a method for determining a mix rate of genetically modified wheat in a test sample. | 2012-02-16 |
20120040863 | PROCESS FOR TUMOUR CHARACTERISTIC AND MARKER SET IDENTIFICATION, TUMOUR CLASSIFICATION AND MARKER SETS FOR CANCER - A process to identify tumour characteristics involves obtaining three different marker sets each predictive of a characteristic of interest, obtaining a sample gene expression signals from tumour cells, adding a reporter to affect a change in the sample permitting assessment of a gene expression signal of interest in the tumour, combining the gene expression signals with the reporter, correlating the extracted gene expression signals to the three different marker sets, assigning a designation to the extracted gene expression signals according to the following rankings: if the correlation of all three predictive gene expression signal sets predict it to have characteristics of concern, it is designated a bad tumour; if the correlation of all three predictive gene expression signal sets predict it to lack characteristics of concern it is designated a good tumour; and, if the correlation of all three predictive gene expression signal sets do not provide the same predicted clinical outcome, the tumour is designated as “intermediate”; and, outputting said designation. | 2012-02-16 |
20120040864 | Method for Determining the Cbl-b Expression - The present invention relates to methods of determining intracellular Cbl-b protein in cells of a sample, comprising
| 2012-02-16 |
20120040865 | TARGET SUBSTANCE DETECTION METHOD USING APTAMER - The present invention relates to a method and kit of detecting a target material using an aptamer, and more particularly to a method and kit for detecting a target material, in which a sample and a second aptamer are added to a first aptamer immobilized on a solid phase so as to form a bond sandwiched between the first aptamer, the target material and the second aptamer, to an FET sensor-based method and kit for detecting a target material, and to an AAO sensor-based method and kit for detecting a target material. | 2012-02-16 |
20120040866 | High Resolution Label Free Analysis of Cellular Properties - The invention provides methods of detecting a change in cell growth patterns. | 2012-02-16 |
20120040867 | Microarrays of Binary Nucleic Acid Probes for Detecting Nucleic Acid Analytes - Some embodiments of the invention are directed to a microarray of binary nucleic acid probes for the detection of one or a plurality of nucleic acid analytes in a complex sample in a single high throughput assay with extraordinary specificity under physiologic conditions. Any binary nucleic acid probes that generate a detectable signal when bound to analyte are suitable for use in the microarrays, including binary deoxyribozyme or ribozyme probes; nonenzymatic binary probes for fluorescent detection, nonenzymatic binary dye-binding probes, and binary split enzyme peroxidase probes for visual detection of nucleic acids. The invention is also directed to new non nonenzymatic binary probes that bind to reporter oligonucleotides. | 2012-02-16 |
20120040868 | Combinatorial Synthesis of Diamond - Disclosed is a combinatorial synthesis of Diamond wherein a first reactive species is produced by catalytic treatment of Acetylene, a second reactive species is produced by decomposition of a hydrocarbon source having a low Hydrogen-to-Carbon ratio using a high energy discharge, and the two reactive species so obtained are combined in the vapor phase to yield Diamond without the need of post-treatments. The reaction is efficient and affords Diamond under mild conditions with high purity such that it may be useful for producing Diamond for semiconductor and microelectronics applications. | 2012-02-16 |
20120040869 | SEQUENCE PRESERVED DNA CONVERSION - Described herein are inexpensive high throughput methods to convert a target single stranded DNA (ssDNA) such that each nucleotide (or base) adenine (A), thymine (T), guanine (G) and cytosine (C) is converted to a pre-determined oligonucleotide code, with the sequential order preserved in the converted ssDNA, or RNA. The method does not require the use of DNA polymerases during the cycles and involves the use of an oligonucleotide probe library with repeated cycles of ligation and cleavage. At each cycle, one or more nucleotides on one end (e.g., either the 5′ end or the 3′ end) of a target, e.g., ssDNA, are cleaved and then ligated with the corresponding oligonucleotide code at the other end of the target ssDNA. | 2012-02-16 |
20120040870 | Method For Assembly Of Polynucleic Acid Sequences - The present invention provides a method for the assembly of a polynucleic acid sequence from a plurality of nucleic acid sequences in which the polynucleic acid sequence is of a formula N | 2012-02-16 |
20120040871 | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION - Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided. | 2012-02-16 |
20120040872 | PREPARING CARBOHYDRATE MICROARRAYS AND CONJUGATED NANOPARTICLES - The present invention is directed to carbohydrate microarray and conjugated nanoparticles methods of making the same. | 2012-02-16 |
20120040873 | GLYCEROL BASED DRILLING FLUIDS - The present invention relates to glycerol based drilling fluids. In particular, the invention relates to drilling fluids comprising a 95-20 volume % glycerol/water solution capable of stabilizing water-sensitive formations during drilling and the use of such solutions for drilling a well having water-sensitive formations. | 2012-02-16 |
20120040874 | GEAR OIL COMPOSITION - A particular gear oil composition is provided that contains (A) a base oil, (B) an ethylene-α-olefin copolymer, (C) a sulfur-containing compound, (D) an organomolybdenum compound and (E) a phosphorus-containing compound, which is excellent in extreme pressure properties, shear stability and wear resistance, and is excellent in fuel saving properties. | 2012-02-16 |
20120040875 | Water-Based Hydraulic Fluids Comprising Dithio-Di(Aryl Carbolic Acids) - The invention relates to water-based hydraulic fluids comprising a) water, b) at least one glycol, a polyglycol, or both, and c) 0.1 to 30 wt % of at least one compound of formula 1, | 2012-02-16 |
20120040876 | Anthranilic Esters as Additives in Lubricants - This invention relates to anthranilate esters and their use in lubricants, such as engine oils. The invention particularly relates to compositions that deliver an ash-free base to a lubricant in the form of a basic amine additive, without adversely impacting seal compatibility and/or degradation, and methods thereof. | 2012-02-16 |
20120040877 | AQUEOUS LUBRICANT - Provided is a water-based lubricant comprising a hyperbranch-type polyglycerol having an absolute molecular weight of from 5,000 to 500,000. The water-based lubricant has a small friction coefficient and is excellent in lubrication performance and defoamability, as compared with conventional water-based lubricants comprising an ethylene/propylene oxide copolymer, and is favorable, for example, for a water-based metal processing agent and a hydraulic pressure fluid. | 2012-02-16 |
20120040878 | PROCESS FOR PRODUCING ALPHA-OLEFIN POLYMER, ALPHA-OLEFIN POLYMER, AND LUBRICATING OIL COMPOSITION - Provided is a method of producing an α-olefin polymer including a step of polymerizing one or more kinds of α-olefins each having 6 to 20 carbon atoms with a catalyst obtained by using a specific transition metal compound. By the method, an α-olefin polymer having a viscosity suitable for use in a lubricating oil can be produced on an industrial scale with ease, and further, the characteristics of the product can be widely changed through the control of reaction conditions. | 2012-02-16 |
20120040879 | Alpha-Silyl Alcohols Possessing Olfactory Properties Reminiscent Of Patchouli Oil - The present disclosure refers to sila-substituted carbinols of formula (I) | 2012-02-16 |
20120040880 | CARBOXY ESTER KETAL REMOVAL COMPOSITIONS, METHODS OF MANUFACTURE, AND USES THEREOF - A removal composition is described, having a plurality of abrasive particles, an organic amine, antioxidant, biocide, colorant, corrosion inhibitor, cosolvent, defoamer, dye, enzyme, light stabilizer, odor masking agent, plasticizer, preservative, rust inhibitor, surfactant, thickener, or a combination comprising at least one of the foregoing; from 0 to 1% water, based on the total weight of the removal composition; and a ketal adduct of formula (1) | 2012-02-16 |
20120040881 | GRAYING-INHIBITING WASHING AGENT - The invention relates to new triazine derivatives, the use of new triazine derivatives as graying-inhibiting active substances, and washing agent compositions comprising the new triazine derivatives as graying-inhibiting active substances along with surfactant and other ingredients found in detergent compositions. | 2012-02-16 |
20120040882 | METHOD OF REMOVING ENHANCED FOOD SOIL FROM A SURFACE USING A SULFONATED ALKYL POLYGLUCOSIDE COMPOSITION - A cleaning composition including a sulfonated functionalized alkyl polyglucoside, a co-surfactant, a water conditioning agent and water. The sulfonated functionalized alkyl polyglucoside is one of a C | 2012-02-16 |
20120040883 | METHOD OF REMOVING ENHANCED FOOD SOIL FROM A SURFACE USING A SULFONATED ALKYL POLYGLUCOSIDE COMPOSITION - A method of using a cleaning composition including a sulfonated functionalized alkyl polyglucoside, a co-surfactant, a water conditioning agent and water. The sulfonated functionalized alkyl polyglucoside is one of a C | 2012-02-16 |
20120040884 | Methods and Reagents for Treatment and Diagnosis of Vascular Disorders and Age-Related Macular Degeneration - Disclosed are screening methods for determining a human subject's propensity to develop a vascular disorder and/or age-related macular degeneration (AMD), therapeutic or prophylactic compounds for treating disease or inhibiting its development, and methods of treating patients to alleviate symptoms of the disease, prevent or delay its onset, or inhibit its progression. The inventions are based on the discovery that persons with a genome having a deletion of the CFHR-1 and/or CFHR-3 gene, which normally lie on human chromosome 1 between DNA encoding CFH and CFHR-4, are at reduced risk of developing AMD, and elevated risk of developing vascular disease such as aneurysm. | 2012-02-16 |
20120040885 | Analogues of Neuropeptide Y Having At Least One Synthetic Amino Acid Substitution - The present invention relates to novel analogues of neuropeptide Y, pharmaceutical compositions containing the same, pharmaceutical formulations containing the same, and method of treating diseases or conditions mediated by neuropeptide Y-receptor binding. More particularly, the present invention relates to novel analogues of neuropeptide Y having at least one unnatural amino acid substitution, such as 4Hyp at position 34, that selectively bind to the neuropeptide Y1 receptor subtype compared to the neuropeptide Y2 receptor subtype. | 2012-02-16 |
20120040886 | Analogues of Neuropeptide Y Having Proline Substitution At Position 34 - The present invention relates to novel analogues of neuropeptide Y, pharmaceutical compositions containing the same, pharmaceutical formulations containing the same, and method of treating diseases or conditions mediated by neuropeptide Y-receptor binding. More particularly, the present invention relates to novel analogues of neuropeptide Y having proline substitution at position 34 and other substitution(s) as defined herein that selectively bind to the neuropeptide Y1 receptor subtype compared to the neuropeptide Y2 receptor subtype. | 2012-02-16 |
20120040887 | COMPOSITION FOR THE TREATMENT OF OSTEOMYELITIS, METHOD FOR PREPARING THE SAME, AND METHOD FOR THE TREATMENT OF OSTEOMYELITIS - The disclosure provides a composition for the treatment of osteomyelitis and a method for preparing the same. The composition includes: 100 parts by weight of water; 0.06-0.1 parts by weight of an antibiotic; and 5-40 parts by weight of a biodegradable thermosensitive polymer, wherein the biodegradable thermosensitive polymer has a structure as following: | 2012-02-16 |
20120040888 | ANTI-INFECTIVE HYDROXY-PHENYL-BENZOATES AND METHODS OF USE - The invention provides a method for preventing or treating a disease caused by an extracellular microorganism, said method comprising systemically administering to a subject in need thereof a prophylactically or therapeutically effective amount of a salicylic acid (SAL) or a SAL analogue. The extracellular microorganism can be of the bacterial genus | 2012-02-16 |
20120040889 | PEPTIDOMIMETIC MACROCYCLES - The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease. | 2012-02-16 |
20120040890 | INHIBITOR OF THE URACIL-DNA GLYCOSYLASE ENZYME AND USES THEREOF - The present invention relates to a protein which has the capacity to bind to and inhibit the viral uracil DNA glycosylase (UDG) enzyme and its use as a therapeutic agent; in particular, as an antiviral agent. | 2012-02-16 |
20120040891 | HIV FUSION INHIBITOR PEPTIDES WITH IMPROVED BIOLOGICAL PROPERTIES - Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions. | 2012-02-16 |
20120040892 | Methods and Compositions for the Treatment of Heart Failure and Other Disorders - Peptides that act as GC-C receptor agonists and contain at least one D-cys and are useful for the treatment of diuresis and heart disease as well as other disorders are described. | 2012-02-16 |
20120040893 | MODIFICATION OF FEEDING BEHAVIOUR - Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering PYY or an agonist thereof and GLP-1 or an agonist thereof to the subject, simultaneously or sequentially, thereby decreasing the calorie intake of the subject. | 2012-02-16 |
20120040894 | Mini-Hepcidin Peptides and Methods of Using thereof - Disclosed herein are peptides which exhibit hepcidin activity and methods of making and using thereof. | 2012-02-16 |
20120040895 | PEPTIDE AVAILABILITY - The present invention provides a process for producing a composition which is preferably a food, food intermediate, nutraceutical, dietary supplement, feed, or pet food, which comprises mixing together a peptide, preferably a bioactive peptide, and a dietary fibre. | 2012-02-16 |
20120040896 | COMPOSITIONS, METHODS AND USES FOR MODULATION OF BRCA 1 - Embodiments of the present invention generally relate to methods, compositions and uses for diagnosis and treatment of cancer. Certain embodiments report methods and compositions for diagnosing and/or treating a subject having a BRCA1-related cancer or sporadic cancer. Some embodiments disclose treatments that can include, but are not limited to, modulation of BRCA1. In some embodiments, methods for identifying a subject with unstable BRCA1 protein are reported. | 2012-02-16 |
20120040897 | NOVEL DERIVATIVES OF ACYL CYANOPYRROLIDINES - A compound of formula (I) or a tautomeric form, regioisomer, stereoisomer, solvate, N-oxide or pharmaceutically acceptable salts thereof; wherein ‘a’—is selected from the group consisting of substituted or unsubstituted heterocycloalkyl ring and substituted or unsubstituted carbohydrate moiety y is a member selected from —O—, —CO—, —S02-, aminoalkyl or formula (II) wherein, R | 2012-02-16 |
20120040898 | PHARMACEUTICAL COMPOSITIONS - A pharmaceutical composition comprising a combination of
| 2012-02-16 |
20120040899 | Method for Treating Hyperglycemia with GLP-1 - A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with type 2 diabetes mellitus who have a fasting blood glucose concentration greater than about 8 mM, wherein the patient is administered a formulation comprising a GLP-1 molecule and a diketopiperazine by pulmonary inhalation with a dry powder inhalation system. | 2012-02-16 |
20120040900 | COMPOSITIONS OF AND METHODS OF USING LIGAND DIMERS - Provided herein are ligand dimers, compositions thereof, as well as methods of their use. The ligand dimers provided can comprise at least one ligand to a Her receptor and can be used to force dimerization of specific receptor pairs. The forced dimerization of specific receptor pairs can be used to control (e.g., promote or inhibit) signaling, and, therefore, the ligand dimers provided can also be used in various forms of treatment in which such signaling control is beneficial to a subject. It follows that methods for controlling signaling are provided as are various methods of treatment. | 2012-02-16 |
20120040901 | NOVEL BIOMATERIALS, THEIR PREPARATION AND USE - The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps:
| 2012-02-16 |
20120040902 | METHOD OF TREATING DYSPNEA ASSOCIATED WITH ACUTE HEART FAILURE - The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin. | 2012-02-16 |
20120040903 | METHOD FOR TREATING DYSPNEA ASSOCIATED WITH ACUTE HEART FAILURE - The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin. | 2012-02-16 |
20120040904 | Boronate Medicaments for Preventing Thrombosis During Surgery - The use for the manufacture of a medicament for preventing unwanted coagulation during surgery, and particularly a Coronary Artery By pass Graft (CABG) procedure, of boronic acids of formula (I), and salts, prodrugs and prodrug salts thereof; wherein Y comprises a moiety which, together with the fragment —CH(R | 2012-02-16 |
20120040905 | MEANS FOR PURIFYING A COAGULATION PROTEIN, AND METHODS FOR IMPLEMENTING SAME - An affinity substrate for selectively binding a coagulation protein, includes a substrate solid on which nucleic aptamers binding specifically to the coagulation protein are immobilized. | 2012-02-16 |
20120040906 | PROTEIN TARGETS IN DISEASE - MicroRNAs have been shown to be critically involved in control of cell survival and cell death decisions. By identifying microRNAs implicated in Endoplasmic Reticulum stress-induced cardiomyocyte apoptosis, it is envisaged that protein targets involved in same can be identified through specifically selected microRNAs. The microRNAs targeted are miR-351, miR-322, miR-125, miR-424 and miR-7a. Furthermore, the potential application of these identified proteins in the treatment of cardiovascular disease, in particular congestive heart failure, is disclosed. | 2012-02-16 |
20120040907 | Method of Use of Bioactive Materials - A bioactive material is made using fibroin solutions and suspensions designed to support the constructions, repair, regeneration or augmentation of bone and other tissues of the body. The fibroin solutions, suspensions, and composites can be injected to fill cavities or to replace missing tissue. After injection, the materials can produce a scaffold capable of promoting tissue regeneration while degrading. The ability to inject the fibroin solutions, suspensions and composites can reduce the need for many types of surgical procedures that are used to replace or repair bone and other tissues. The fibroin solutions and suspensions are particularly useful for methods of tissue construction and/or repair. | 2012-02-16 |
20120040908 | FRACTURE REPAIR PROMOTER - Disclosed is a substance capable of promoting the repair of a fractured part in a fracture caused by an external force, fatigue or a disease. Also disclosed is a method for producing the substance. Further disclosed is a product capable of promoting the repair of a fracture, such as a food, a beverage and a feed, which comprises the fracture repair promoter. Specifically disclosed is a fracture repair promoter comprising, as an active ingredient, a fraction containing a milk-derived basic protein. In the promoter, the fraction containing the milk-derived basic protein is produced by contacting milk or a milk-derived raw material with a cation exchange resin to cause the adsorption of the basic protein on the cation exchange resin and eluting a fraction adsorbed on the resin by means of an eluent having a salt concentration of 0.1 to 1.0 M. | 2012-02-16 |
20120040909 | IDENTIFICATION OF NOVEL ANTAGONIST TOXINS OF T-TYPE CALCIUM CHANNEL FOR ANALGESIC PURPOSES - A peptide with the following sequence YCQKFLWTCDSERPCCEGLVCRLWCKIN (SEQ ID NO 1) or a derivative thereof, and nucleic acids coding for the peptide having the sequence (SEQ ID NO 1). Also the use of this peptide as an antagonist and/or reverse agonist of T-type calcium channels. A use of the peptide for preparing a drug, in particular an analgesic one. | 2012-02-16 |
20120040910 | METHODS OF PREVENTING OR TREATING BRAIN DISEASES - The present invention relates to methods for preventing or treating neurological diseases, particularly brain diseases, and improving cognitive functions using a composition comprising stanniocalcin 2 as an active ingredient. | 2012-02-16 |
20120040911 | TARGETED DELIVERY OF BOTULINUM TOXIN FOR THE TREATMENT AND PREVENTION OF TRIGEMINAL AUTONOMIC CEPHALGIAS, MIGRAINE AND VASCULAR CONDITIONS - Botulinum toxin, among other presynaptic neurotoxins is used for the treatment and prevention of migraine and other headaches associated with vascular disorders. Presynaptic neurotoxins are delivered focally, targeting the nerve endings of the trigeminal nerve, the occipital nerve and the intranasal terminals of the parasympathetic fibers originating in the Sphenopalatine ganglion. The administration preferably targets the extracranial nerve endings of the trigeminal nerve in the temporal area, the extracranial occipital nerve endings in the occipital area, and the intranasal terminals of the trigeminal nerve and parasympathetic fibers originating in the Sphenopalatine ganglion. The delivery is carried out by way of injection or topically. | 2012-02-16 |
20120040912 | PROTEASOME-ACTIVATING ANTI-AGING PEPTIDES AND COMPOSITIONS CONTAINING SAME - The present invention relates to peptidic compounds of general formula (I): | 2012-02-16 |
20120040913 | METHODS AND COMPOSITIONS FOR TREATING DIABETES - The instant invention provides a method of treating an animal suffering a disease characterized by excessive apoptosis by administering a therapeutically effective amount of at least one serine protease inhibitor and thereafter monitoring a decrease in apoptosis. The inhibitor of the invention includes α | 2012-02-16 |
20120040914 | ENHANCING EFFECTIVENESS OF GLIAL CANCER THERAPIES - A method of enhancing the effectiveness of a chemotherapeutic agent, such as Temozolomide (TMZ), or ionizing radiation against glioblastoma is described in the present invention. The method comprises targeting putative membrane androgen receptor (termed mAR) in glioma cells to enhance the cytotoxic effects of a chemotherapeutic agent or ionizing radiation while simultaneously affording protection to neighboring neurons. | 2012-02-16 |
20120040915 | PEPTIDES AND NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer. | 2012-02-16 |
20120040916 | MOLECULAR INHIBITORS OF THE WNT/BETA-CATENIN PATHWAY - The present invention is directed toward a method of treating a subject for a condition mediated by the Wnt/β-catenin pathway by selecting a subject with a condition mediated by the Wnt/β-catenin pathway and administering to the selected subject a compound selected from the group consisting of those set forth in Table 1, Table 2, and a pharmaceutically acceptable salt thereof. A method of similarly inhibiting the Wnt/β-catenin pathway in a subject is also disclosed. | 2012-02-16 |
20120040917 | Splice Switching Oligomers for TNF Superfamily Receptors and Their Use in Treatment of Disease - The present invention relates to compositions and methods for preparing splice variants of TNFalpha receptor (TNFR) in vivo or in vitro, and the resulting TNFR protein variants. Such variants may be prepared by controlling the splicing of pre-mRNA molecules and regulating protein expression with splice switching oligonucleotides or splice switching oligomers (SSOs). The preferred SSOs according to the invention target exon 7 or 8 of TNFR1 (TNFRSF1A) or TNFR2 (TNFRSF1A) pre-mRNA, typically resulting in the production of TNFR variants which comprise a deletion in part or the entire exon 7 or 8 respectfully. SSOs targeting exon 7 are found to result in a soluble form of the TNFR, which has therapeutic benefit for treatment of inflammatory diseases. The SSO's are characterized in that they are substantially incapable or incapable of recruiting RNaseH. | 2012-02-16 |
20120040918 | PEPTIDE NUCLEIC ACID DERIVATIVES WITH GOOD CELL PENETRATION AND STRONG AFFINITY FOR NUCLEIC ACID - The present invention provides a novel class of peptide nucleic acid derivatives, which show good cell penetration and strong binding affinity for nucleic acid. | 2012-02-16 |
20120040919 | EXFOLIATING COMPOSITION BASED ON CREAM OF TARTAR AND BICARBONATE - A solid exfoliating composition includes a surfactant, sodium bicarbonate, cream of tartar, and a granular exfoliant. | 2012-02-16 |
20120040920 | OLIGOSACCHARIDE ALDONIC ACIDS AND THEIR TOPICAL USE - Methods for using compositions comprising oligosaccharide aldonic acids for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and/or extrinsic aging, as well as with changes or damage caused by extrinsic factors; general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa; for general oral care, as well as treatment and prevention of oral and gum diseases; and for wound healing of the skin. Methods may comprise using compositions comprising oligosaccharide aldonic acids and additional cosmetic, pharmaceutical or other topical agents to enhance or create synergetic effects. | 2012-02-16 |
20120040921 | COMPOSITIONS AND PRODUCTS CONTAINING S-EQUOL, AND METHODS FOR THEIR MAKING - A composition for use in making commercial food and skin products comprising 5-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments. The compositions are useful in a method of delivering S-equol to a mammal to prevent or treat a disease or associated condition, including hormone-dependent diseases or conditions such as cardiovascular disease, lipid disorder, osteopenia, osteoporosis, liver disease, and acute ovarian estrogen deficiency. The S-equol enantiomer can be produced in a biological synthesis from the metabolism of an isoflavone by an organism. | 2012-02-16 |