04th week of 2010 patent applcation highlights part 40 |
Patent application number | Title | Published |
20100021832 | PHOTORESIST COMPOSITION AND METHOD OF MANUFACTURING A COLOR FILTER SUBSTRATE BY USING THE SAME - A photoresist composition includes a coloring agent, a binder resin, a cross-linker, a photo-polymerization initiator and a solvent. The coloring agent includes an anthraquinone-based dye and a pigment. A color filter formed from the photoresist composition has a relatively greater light-transmittance. Thus, a contrast of a display apparatus having the color filter may be improved. | 2010-01-28 |
20100021833 | DITHIOLENE METAL COMPLEX COLORLESS IR ABSORBERS - The invention relates to the use of compounds of formulae (I) and/or (II) as colorless IR absorbers wherein M is Ni, Pd, Pt, Au, Ir, Fe, Zn, W, Cu, Mo, In, Mn, Co, Mg, V, Cr or Ti, X | 2010-01-28 |
20100021834 | COATING COMPOSITIONS FOR FUSERS AND METHODS OF USE THEREOF - There is disclosed a fuser member comprising a substrate; and an outer layer thereover comprising (a) a polymer and (b) an organometallic species, wherein said polymer and said organometallic species forms an interpenetrating network upon curing; and wherein the outer layer comprises an increased number of uniform organometallic binding sites, as compared to an outer layer devoid of the interpenetrating network. An image forming apparatus comprising the disclosed fuser member is also disclosed. Moreover, a method of forming a polymer system suitable for use in color fusing applications is disclosed. | 2010-01-28 |
20100021835 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER AND ELECTROPHOTOGRAPHIC APPARATUS - The present invention provides an electrophotographic photosensitive member in which a photoconductive layer is an amorphous layer that contains a silicon atom as a main component, and a surface layer contains an aluminum atom, a zinc atom and an oxygen atom so as to satisfy Expression (1) and Expression (2): | 2010-01-28 |
20100021836 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER AND ELECTROPHOTOGRAPHIC APPARATUS - In an electrophotographic photosensitive member having a photoconductive layer and, provided on the photoconductive layer, a surface layer constituted of a hydrogenated amorphous silicon carbide, the ratio of the number of atoms of carbon atoms (C) to the sum of the number of atoms of silicon atoms (Si) and number of atoms of carbon atoms (C), C/(Si+C), in the surface layer is from or more to 0.75 or less, and the sum of atom density of the silicon atoms and atom density of the carbon atoms in the surface layer is 6.60×10 | 2010-01-28 |
20100021837 | METHOD FOR MANUFACTURING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER - The present invention provides a method for manufacturing an electrophotographic photosensitive member including: forming a first surface layer and a second surface layer of the electrophotographic photosensitive member by supplying a source gas into a reaction vessel so that C | 2010-01-28 |
20100021838 | POLYMER PARTICLES WITH ADDITIVES ENCAPSULATED IN MICROVOIDS - Porous particles comprising a polymer binder and at least one additive distinct from any pore stabilizing compound present in the particle, wherein: the polymer binder comprises a solid compositionally continuous phase having an external particle surface; discrete pores are dispersed within the solid compositionally continuous phase, forming internal pore surfaces; and the at least one additive is present primarily in the discrete pores. The additive may further preferably not be present in the solid compositionally continuous phase, and be substantially absent from the external particle surface. A toner set for forming a color electrophotographic image comprising a plurality of different colored toners, where at least one of the different colored toners comprise such porous particles comprising additives, and in a particular embodiment wherein at least two different colored toners each comprise different pigments present primarily in the internal pores. A process of making such porous particles. | 2010-01-28 |
20100021839 | TONER COMPOSITIONS - Methods for modifying the acid value of an unsaturated polyester resin suitable for use in forming toner particles are provided. In embodiments, methods may include contacting at least one unsaturated polyester resin with at least one grafting monomer, polymerizing the graft monomer and unsaturated polyester resin to form a graft copolymer, and then utilizing the graft copolymer to form toner particles by combining the graft copolymer with an optional colorant, at least one surfactant, and an optional wax. Toners produced by these methods are also provided. | 2010-01-28 |
20100021840 | DECOLORIZABLE EMULSION COLORING MATERIAL AND METHOD OF PRODUCING THE SAME - There is provided an emulsion coloring material which can be used on ordinary paper, has good color developability, and can be used for conventional erasable pens or printing inks of black or blue color, having sufficiently high densities. When use is made of an erasable emulsion coloring material capable of controlling color development and decolorization by the presence or absence of the interaction between a chromatic material and a color developer, the colored emulsion comprising a copolymer resin of at least one unit selected from styrene and styrene derivatives and at least one unit selected from an acrylic acid ester and a methacrylic acid ester having a substituent which comprises a carbon chain having 4 or more carbon atoms, coloring ability can be enhanced. | 2010-01-28 |
20100021841 | LOW MELT TONERS AND PROCESSES THEREOF - A process for preparing toner particles and compositions adapted for use in preparing toners that comprise a blend of a first polyester resin with a second sharp melting polyester resin. The process includes forming an emulsion resin comprising a branched polyester resin, a crystalline polyester resin, a colorant, and optionally a wax. The resin mixture is aggregated using an aggregating agent, such as a zinc acetate solution, to form an aggregate mixture. The aggregate mixture is then coalesced at a temperature of from about 5 to about 20° C. above the T | 2010-01-28 |
20100021842 | LASER ENGRAVABLE FLEXOGRAPHIC PRINTING ARTICLES BASED ON MILLABLE POLYURETHANES, AND METHOD - A flexographic printing sleeve or plate is made by a method that includes providing a millable polyurethane, crosslinking the millable polyurethane, and forming a relief by at least laser engraving the crosslinked millable polyurethane. For example, crosslinking may be accomplished by a peroxide-based process or by a vulcanization process using sulfur. A relief in one example is formed by extruding the millable polyurethane, thermally crosslinking the polyurethane after the extrusion step and laser engraving the crosslinked millable polyurethane. A printing article is formed into the shape of a flat printing plate or a continuous in-the-round printing sleeve. | 2010-01-28 |
20100021843 | Inorganic Resist Sensitizer - Methods and compositions for enhancing the sensitivity of an inorganic resist composition are disclosed. In one aspect, compositions for use with a matrix material (e.g., a lithographically sensitive polymeric material such as a hydrogen-bearing siloxane material) can be formulated with a sensitizer, where the sensitizer can be present in a relatively small amount. The sensitizer can include a radical generator, and can act to enhance the efficiency of radical generation and/or resist crosslinking when the resist is impinged by a selected lithographic radiation. The methods of the present invention can be especially useful in performing short wavelength (e.g., less than 200 nm) lithography, or for processes such as e-beam lithography, which traditionally suffer from low throughput. Methods of utilizing one or more of these aspects are also disclosed. | 2010-01-28 |
20100021844 | NEGATIVE-WORKING IMAGEABLE ELEMENTS AND METHOD OF USE - Negative-working imageable elements can be imaged and processed with water to provide lithographic printing plates. These imageable elements have imageable layers that contain a particulate polymeric binder having polyetheramine side chains. Rapid processing speeds are also possible using water and optional mechanical rubbing means for processing the imaged element. | 2010-01-28 |
20100021845 | NEGATIVE WORKING, HEAT-SENSITIVE LITHOGRAPHIC PRINTING PLATE PRECURSOR - A heat-sensitive negative-working lithographic printing plate precursor comprising:
| 2010-01-28 |
20100021846 | NEGATIVE WORKING, HEAT-SENSITIVE LITHOGRAPHIC PRINTING PLATE PRECURSOR - A heat-sensitive negative-working lithographic printing plate precursor comprising:
| 2010-01-28 |
20100021847 | Oxime Compound and Resist Composition Containing the Same - An oxime compound represented by the formula (I): | 2010-01-28 |
20100021848 | METHOD FOR FORMING PATTERN AND METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE - According to an aspect of the present invention, there is provided a method for forming a pattern including: applying a photosensitive resin onto a film on a wafer substrate; partly exposing the photosensitive resin to light and developing the photosensitive resin to form a first pattern having an opening portion; applying a photo-curable material onto the film exposed by the opening portion of the first pattern; bringing one face of an optically-transmissive template having a second pattern formed on the one face into contact with the photo-curable material, the second pattern including projections and reentrants; irradiating the photo-curable material with light; and separating the template from the photo-curable material. | 2010-01-28 |
20100021849 | Method of Forming Patterns of Semiconductor Device - In a method of forming patterns of a semiconductor device, a semiconductor substrate defining photoresist patterns formed over a target etch layer is provided. An auxiliary layer is formed over the semiconductor substrate and the photoresist patterns. The auxiliary layer formed on a surface of the photoresist patterns is denatured into first auxiliary patterns. A photoresist film is formed over the semiconductor substrate, the first auxiliary patterns, and the auxiliary layer. The auxiliary layer formed below the photoresist film is denatured into a second auxiliary pattern. Here, the auxiliary layer remains only between the photoresist patterns. Etch mask patterns, including the photoresist patterns and the auxiliary layer, are formed by removing the photoresist film and the first and second auxiliary patterns. | 2010-01-28 |
20100021850 | PATTERN FORMING METHOD - A pattern forming method has forming a first resist film on a processed film, patterning the first resist film into a first resist pattern, forming a first film containing a photo acid generator so as to cover the first resist pattern, forming a second resist film so as to cover the first film, irradiating a predetermined region of the second resist film with exposure light, heating the first film and the second resist film, performing a development process, removing the second resist film of the predetermined region and forming a second resist pattern while the first film is left, and etching the processed film with the first resist pattern and the second resist pattern as a mask. | 2010-01-28 |
20100021851 | METHODS FOR PRODUCING ORGANIC NANOCRYSTALS - Methods for producing small crystals on islands formed on specialized substrates by, inter alia, subjecting the substrate to a hydrophilic SAMs solution for self-assembling hydrophilic SAMs on certain portions of the substrate surface and subjecting the substrate to a hydrophobic SAMs solution for self-assembling hydrophobic SAMs on certain other portions of the substrate surface. | 2010-01-28 |
20100021852 | COMPOSITION FOR FORMATION OF UPPER LAYER FILM, AND METHOD FOR FORMATION OF PHOTORESIST PATTERN - A composition for formation of upper layer film, which is used for forming an upper layer film on the surface of a photoresist film and which comprises
| 2010-01-28 |
20100021853 | Burner Apparatus And Methods - A burner assembly for and method of combusting fuel gas in a furnace is provided. The burner assembly includes a burner tile having a burner throat disposed therethrough. Combustion air is conducted through the burner throat into a combustion zone in the furnace. A pilot assembly is used to generate a pilot flame within the burner throat. Fuel gas is injected into an ignition zone located outside the burner throat and ignited therein. The pilot flame generated in the burner throat can be used to ignite the fuel gas in the ignition zone. The ignited fuel gas is admixed with combustion air in the combustion zone. The burner assembly can be operated without admixing a significant amount of fuel gas with combustion air in the burner throat, which can help control the formation of undesirable nitrogen oxides (NO | 2010-01-28 |
20100021854 | IGNITER - An igniter can include a safety mechanism which is easily operated by an adult but is difficult for a child to release. In particular, an igniter can include: a nozzle section which emits a flame; a fuel introduction section; an ignition section which ignites the introduced fuel, wherein the ignition section is configured in such a manner that the fuel is ignited by movement of an ignition operating section to an ignition position; a movement restricting section having restricting sections which restrict the movement of the ignition operating section; and a permitting section which permits movement. When moving the movement restricting section, either the restricting sections or the permitting section can be disposed so as to correspond to the direction of movement of the ignition operating section. | 2010-01-28 |
20100021855 | Non-sooting containerized candle - A non-sooting containerized candle is disclosed. The containerized candle includes a container having a top opening and a plurality of holes in an upper side wall portion of the container, a wick, a sustainer for securing the wick to the base of the container, and wax or other fuel material surrounding a major portion of the wick. The plurality of holes can be present in varying patterns in the upper side wall portion of the container to control air flow into and out of the container to provide complete combustion of the candle and prevent emission of carbon particulates. The pattern of holes control or adjust air flow around the burning wick from a turbulent air flow to a laminar air flow. | 2010-01-28 |
20100021856 | SAFETY DOOR FOR ROTARY KILN - A safety door for covering openings in a rotary kiln during maintenance operations on the rotary kiln. The door is affixed to the exterior surface of the rotary kiln and includes a hatch pivotally secured at one side edge thereof by a pivot rod to a frame. A plurality of tension coil springs are disposed on the pivot rod and continuously bias the hatch toward the opening with a force of approximately 400 pounds. | 2010-01-28 |
20100021857 | ORTHODONTIC BRACKET AND USE THEREOF - A bracket for attaching an arch wire to a tooth includes a dental plate with a back and a front, wherein the back is intended to be attached to a tooth by an adhesive connection, and also an arch wire holder for fastening the arch wire to the bracket, wherein the arch wire holder is fitted at the front of the dental plate. The bracket farther includes an arm, a first end of which is attached, or can be attached, to the dental plate and a second end carries the arch wire holder. The arm extends along the front of the dental plate. The arm is made of bendable wire material, such that the position of the arch wire holder in respect of the dental plate can be adjusted by bending the arm. The invention further relates to the use of a bracket according to the invention. | 2010-01-28 |
20100021858 | INJECTION CORRECTION IMPRESSION TRAY - An injection correction impression tray ( | 2010-01-28 |
20100021859 | Methods, systems and accessories useful for procedures relating to dental implants - A method and system are provided for manufacturing a physical dental model. A virtual model is provided representative of at least a portion of the intra-oral cavity including at least one dental implant implanted therein, and the virtual model includes a virtual portion representative of each dental implant. The virtual spatial disposition of each such virtual portion is determined with respect to the virtual model, corresponding to a real spatial disposition of the respective implant with respect to the intra oral cavity. A physical model is then manufactured based on the virtual model, the physical model including a physical analog corresponding to each implant at a respective physical spatial disposition with respect to the physical model corresponding to the respective virtual spatial disposition of the respective virtual portion with respect to the first virtual model as already determined. In some embodiments, a jig is provided configured for maintaining a desired physical spatial disposition between the physical analog and a cavity of the physical dental model at least until the physical analog is affixed in the cavity. | 2010-01-28 |
20100021860 | Ergonomic high volme evacuator system - An ergonomic high volume evacuator system provides a tapered tubular evacuator tool having a body defining a medial channel with an angulated mirrored guard having an optically reflective insert adjacent a beveled input orifice. A flexible evacuation hose having an integral coil spring and a vacuum connector pneumatically releasably interconnect the evacuator tool with a vacuum source. An axially rotatable evacuator tool connector provides a releasable pneumatic and fluidic sealed interconnection between the evacuator tool and the evacuation hose. | 2010-01-28 |
20100021861 | Tooth grinding system - A tooth grinding system includes an electric motor, a drive unit driven by the motor, a float arm attached to the electric motor at one end, a cutter head at the distal end of the arm including a drive assembly and a cutter element driven by the drive assembly and a flexible drive member within the arm and driven by the drive unit to drive the drive assembly and cutter element. | 2010-01-28 |
20100021862 | Novel method and device for positioning patients for dental imaging - The present invention relates to methods and devices for positioning a patient's head prior to radiographic analysis for orthodontic and dental applications. According to certain embodiments of the invention, such methods comprise disposing a device in the patient's mouth and having the patient bite down on the device. The device used in such methods includes a planar radiolucent material having a mouthpiece in the center portion thereof, which is adjacent to a first concave contour that approximates the patient's left cheek and a second concave contour that approximates the patient's right cheek. The device used in such methods further comprises an outer horizontal edge that extends outwards from the patient's mouth, which is aligned with the patient's occlusal plane. According to certain embodiments, such methods further comprise taking measurements for dental or orthodontic applications relative to the patient's occlusal plane. | 2010-01-28 |
20100021863 | Dental Retractor - A dental retractor for employment during dental and oral surgery procedures. The device employs a reflective surface at a distal end which is conventionally used adjacent to the surgery site in the patient's mouth. The reflective surface eliminates the need for additional mirrors and such in the patient's mouth. Additionally provided is a proximal end that will adapted for ergonomic positioning in the hand of the user. | 2010-01-28 |
20100021864 | Manual driver for implant drills and method of dental implantation - A manual driver for a dental implant drill or other dental implant tools and the method of use for preparing for dental implantation are provided. The manual driver includes a handle, an extension shank and a chuck having an axial channel configured to receive and interlock an implant drill, and a fastening screw transverse to the axial channel. The method of manual preparation for dental implantation using the manual driver has a high precision, and reduces the risk of bone cracking caused by vibration of motor-driven drilling. The manual drilling method provides better tactile sensation and drilling control to the dentist. Further, the method avoids drilling irrigation, allows collection of virgin bone tissue from the drills, and reintroduces the collected bone tissue in the receiving bore to promote bone regeneration after the implantation. | 2010-01-28 |
20100021865 | METHOD FOR MANUFACTURING IMPLANT ABUTMENTS FOR DENTAL IMPLANTS, AND AN IMPLANT ABUTMENT FOR A DENTAL IMPLANT - The invention relates to a method for manufacturing implant abutments | 2010-01-28 |
20100021866 | Method of producing tooth, set of teeth, and method of producing tissue - A first cell mass substantially containing only either one of mesenchymal cells or epithelial cells and a second cell mass substantially containing only the other one of the cells are positioned in contact with each other inside a support carrier which can maintain a condition of cell contact; and cultured to obtain a tooth having a specific cell placement. Preferably, after the culturing, the support carrier having both cell masses is cultured with kidney cells. | 2010-01-28 |
20100021867 | METHOD AND APPARATUS FOR HARD TISSUE TREATMENT AND MODIFICATION - A device and method for forming a texture on a surface of a hard material. Spatial patterns, such as an array of microbeams, are delivered to the tissue through the handpiece. The plurality of microbeams illuminate and ablate the hard material simultaneously. Each of the microbeams has of a sufficient fluence and pulse width to ablate the surface of the hard material and form the texture. Alternatively, one microbeam of a sufficient fluence and pulse width to ablate the surface of the hard material and form the texture is scanned over the surface either manually or in an automatic fashion. | 2010-01-28 |
20100021868 | DENTAL CROWN FORMS AND METHODS - Dental crown forms and methods of using them are disclosed. The dental crown forms may include one or more of the following features: a handle attached to the dental crown form at a location removed from the base of the dental crown form; a vented handle through which excess amounts of hardenable dental material can pass during placement of the crown form; and one or more lines of weakness that may be separated to remove a dental crown form from hardenable dental material after placement of the filled crown form. The dental crown forms may also be located in packages with hardenable dental material located within the dental crown forms as packaged. | 2010-01-28 |
20100021869 | (METH)ACRYLOYL-CONTAINING MATERIALS, COMPOSITIONS, AND METHODS - Di-, tri-, and/or tetra-(meth)acryloyl-containing materials and compositions are provided. Such materials and compositions can preferably be hardened, without undue shrinkage, to provide hardened materials and/or compositions with properties useful, for example, in dental applications. In one aspect, the present invention provides a compound of the formula (Formula I) wherein: each X independently represents an oxygen atom (O) or a nitrogen atom (N); Y and A each independently represent an organic group, with the proviso that Y does not represent —NHCH | 2010-01-28 |
20100021870 | System and method for teaching software development processes - An exemplary system and method are disclosed for interactively teaching software development processes to multiple users. The exemplary system may include a discrete event simulator for teaching software development that allows a software development team to simulate an entire software development project much faster than real time. The system teaches an entire software development team a set of formal or informal processes using a project simulation. In the course of using the system, each member of the team learns the processes, and together, the entire team learns how to use the processes as a team. The system enables each team member to learn software development processes as well as how those processes translate into team interactions in practice. The system also enables the team to learn how to apply the processes in difficult situations. | 2010-01-28 |
20100021871 | TEACHING READING COMPREHENSION - A creation system and method for creating routines for teaching comprehension are described. The system identifies the skill to be taught, determines one or more features for the identified skill and determines a sequence of routines based on the determined one or more features. A performance system and method for performing the determined routines are also described. The performance system identifies the skill to be taught, determines the sequence of routines for the skill and presents the sequence to the learners. The performance system also provides feedback to the learners for their responses and modifies the sequence of routines based of the learners' responses. | 2010-01-28 |
20100021872 | PROCESS OF LEARNING PROCESS IMPROVEMENT TECHNIQUES - A method of simulating a process. Students are assigned a role related to the process and conduct interviews and investigations via electronic mail to document the process. During the simulation, the students learn the steps involved in the process, and the students learn what steps delay the process and identify the “choke” points in the process. With this information, the students can take action to alter and/or avoid those steps to improve the process. | 2010-01-28 |
20100021873 | STRESS REDUCTION - According to the method and system described the usage of keyboard and mouse by a computer user is analyzed ( | 2010-01-28 |
20100021874 | Inculcating Positive Altered Personal Behavioral Patterns - Disclosed herein is a method of inculcating positive altered personal behavioral patterns in a participant. The participant creates a resource inventory of items that induce a state of well being in the participant. The items may comprise people, spiritual deities, events, places, animals, objects, etc. The participant is led through bilateral stimulation processes by an instructor. Bilateral stimulation of the participant's conscious and unconscious memory networks associated with the items of the resource inventory enables the participant to activate a positive mental state. The instructor then reinforces the positive mental state of the participant. Performance enhancement protocols are applied on the participant in the reinforced positive mental state. Self enhancement exercises invoke positive conditioned responses of the participant. By reinforcing the positive conditioned responses, positive altered personal behavior patterns are inculcated in the participant. | 2010-01-28 |
20100021875 | Medical Simulation System and Method - A method, apparatus and system for simulating the release of radio opaque dye within a vasculature system. The method, apparatus and system include simulating a vessel tree of the vasculature system for display on a display device, activating a particle-based contrast software effect, and injecting a plurality of physics-based particles into a confined vessel space of said vessel tree. The method and apparatus may also include fading down over a period of time an opacity of each of the physics-based particles and opacifying a portion of a vessel wall. | 2010-01-28 |
20100021876 | CPR mannequin - A CPR training mannequin includes a humanoid torso, the torso composed of a material having a degree of transparency. A humanoid head is connected to the torso and has a mouth opening connected to a ventilation tube within the head. The torso is supported by resilient elements from the base to simulate resistance to chest compressions. A simulated heart and simulated lungs are arranged within the torso and are visible through the front surface of the torso. Sensors measure the air flow during CPR ventilation and depth of CPR chest compressions. Lights within the heart, brain and lungs indicate the chest compressions and ventilation are adequate to resuscitate the simulated victim. | 2010-01-28 |
20100021877 | Video Management System for Interactive Online Instruction - A system for interactive online instruction includes an instructional subscription website and video management system configured to process video recordings. The video recordings may include (i) student videos uploaded by a student and (ii) instructor videos providing feedback to said student videos. A method of interactive online instruction is also disclosed. The method includes the steps of providing prerecorded course materials on an instructional subscription website including video lessons accessible by subscribing students, and providing a video management system configured to process video recordings including (i) student videos submitted by a student and (ii) instructor videos providing feedback to said student videos. | 2010-01-28 |
20100021878 | METHOD FOR CLASSIFYING AND COUNTING BACTERIA IN BODY FLUIDS - A method for distinguishing erythroblasts from bacteria by automated hematology analyzers, such as, for example, the CELL-DYN® 4000 automated hematology analyzer and the CELL-DYN® Sapphire™ automated hematology analyzer. Bacterial cells scatter light and fluoresce differently than do red blood cells, white blood cells, erythroblast nuclei, and platelets. Signals generated by bacteria are distinguishable from those of erythroblasts because the signals generated by erythroblast nuclei are sufficiently unique that erythroblast nuclei can be distinguished from signals generated by bacteria. Signals generated by platelets, lysed red blood cell ghosts, and other cell debris are blocked by the triple-trigger circuitry of the hematology analyzer, because all of the signals generated by noise are below the AND/OR thresholds. Algorithm(s) in the software of the system detect and count signals generated by bacteria by means of the location and the shape of the signals generated by bacteria and calculate the concentration of bacteria per unit of body fluid. In addition, certain body fluids, such as, for example, synovial fluid, can be pretreated with a viscosity reducing agent for a short period of time to reduce the viscosity of the body fluid prior to analyzing a sample of the body fluid by an automated hematology analyzer. | 2010-01-28 |
20100021879 | COMPOSITIONS AND METHODS FOR PRESERVING RED BLOOD CELLS - The present invention provides methods, compositions and kits for storing red blood cells for extended periods of time. In particular, the present invention provides methods, compositions and kits for storing red blood cells for extended periods of time while preventing red blood cell storage lesions, retaining red blood cell deformability, and increasing survival of the red blood cells following transfusion. | 2010-01-28 |
20100021880 | Automated Macromolecule Sample Preparation System - An apparatus for preparing a macromolecule sample from a complex liquid mixture includes a hydraulic system adapted for control by an automated controller, comprising a pump and one or more valves. The hydraulic system can be controlled by an automated controller to apply the liquid mixture to one or more filters with a pressure differential across each filter. The filters include a rough filter selected to separate, from a macromolecule in a liquid mixture, at least a portion of one or more rough components in the mixture that are larger than the macromolecule. Further included is a fine filter selected to separate from the macromolecule at least a portion of one or more fine components in the mixture that are smaller than the macromolecule. A method for preparing a macromolecule sample includes automatically acquiring a liquid mixture, the mixture including a macromolecule. At least a portion of the other components in the mixture are automatically separated from the macromolecule by applying the mixture to each of one or more filters, with a pressure differential across each filter. | 2010-01-28 |
20100021881 | Peptide combos and their uses - The invention provides reagents and methods for the accurate quantification of proteins in complex biological samples. Quantification is obtained by adding to a sample a peptide combo, which is essentially a collection of synthetic reference peptides. The synthetic reference peptides have a small mass difference when compared to the biological reference peptides that originate upon digestion from the proteins present in the sample. Reference peptides and synthetic reference peptides are selected and the identity and accurate amounts of reference peptides are determined by mass spectrometry. The methods can be used in high throughput assays to interrogate proteomes. | 2010-01-28 |
20100021882 | METHOD TO DETECT VIRUS RELATED IMMUNOLOGICAL MARKERS FOR THE DIAGNOSIS OF RESPIRATORY TRACT INFECTIONS - This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of respiratory tract viruses-related immunological markers in a serum sample, which can be used for the diagnosis of respiratory tract infections. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of representative antigens used to detect the respective respiratory tract viruses-related immunological markers (antibodies) in blood for the diagnosis of respiratory tract infections. | 2010-01-28 |
20100021883 | DETECTING, MEASURING AND CONTROLLING PARTICLES AND ELECTROMAGNETIC RADIATION - A method is provided for detecting, measuring or controlling particles and/or electromagnetic radiation, comprising providing a deformable material containing a deformable aperture defining a path for particles or radiation, adjusting the deformable aperture to a prescribed geometry and/or size by deforming the deformable material to change at least one of the parameters of the path defined by the deformable aperture, and causing the particle or radiation to be detected, measured or controlled to enter the deformable aperture. The method includes the step of monitoring the geometry and/or size of the deformable aperture and controlling the adjustment of the size of the deformable aperture in response to such monitoring. The required apparatus is easily fabricated from inexpensive materials. Furthermore the deformable aperture can be tuned to the appropriate geometry post fabrication, and the ability to adjust the aperture geometry renders it capable of discriminating a plurality of differently sized particles. | 2010-01-28 |
20100021885 | REAGENT SETS AND GENE SIGNATURES FOR NON-GENOTOXIC HEPATOCARCINOGENICITY - The invention discloses gene signatures for predicting onset of non-genotoxic hepatocarcinogenicity in a subject. The invention also provides methods, apparatuses and reagent sets useful for predicting non-genotoxic hepatocarcinogenicity based on expression levels of genes in specific gene signatures. | 2010-01-28 |
20100021886 | Methods and Materials for Identifying the Origin of a Carcinoma of Unknown Primary Origin - The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into a linear discrimination analysis where the linear discrimination analysis normalizes the Biomarkers against a reference; and imposes a cut-off which optimizes sensitivity and specificity of each Biomarker, weights the prevalence of the carcinomas and selects a tissue of origin determining origin based on highest probability determined by the linear discrimination analysis or determining that the carcinoma is not derived from a particular set of carcinomas; and optionally measuring Biomarkers specific for one or more additional different carcinoma, and repeating the steps for additional Biomarkers. | 2010-01-28 |
20100021887 | PROBE FOR TAGGING VALUABLES BASED ON DNA-METAL COMPLEX - Methods are disclosed involving the formation of complex DNA-Metal and the detection of the complex, such as by employing several analytical methods, e.g., X-Ray Fluorescence, FT-IR and Raman spectroscopy. | 2010-01-28 |
20100021888 | Screening for disease susceptibility by genotyping the CCR5 and CCR2 genes - Provided are compositions, methods and uses for identifying persons at an increased risk of infection by, transmission of, or accelerated progression of a disease caused by an HIV-1 virus. Diagnostic, prognostic and combined therapeutic kits are also provided. | 2010-01-28 |
20100021889 | USING GENETIC POLYMORPHISMS OF THE BICD1 GENE AS A METHOD FOR DIAGNOSING AND TREATING MYOPIA - Using the BICD | 2010-01-28 |
20100021890 | METHOD FOR ANALYTE DETECTION USING PROXIMITY PROBES - The present invention relates to a method for detecting an analyte in a sample, comprising (a) contacting said sample with at least one set of at least first, second and third proximity probes, which probes each comprise an analyte-binding domain and a nucleic acid domain and can simultaneously bind to the analyte, the nucleic acid domain of said third proximity probe being a splint which is capable of hybridising at least to the nucleic acid domains of said first and second proximity probes, wherein when all of the at least three proximity probes bind to said analyte, the nucleic acid domains of said first and second proximity probes are conjugatable by means of an interaction mediated by said hybridised splint of said third proximity probe; (b) conjugating the nucleic acids, of said first and second proximity probes; and (c) detecting said conjugation. Also provided is a kit for use in such a method. | 2010-01-28 |
20100021891 | RGS2 GENOTYPES ASSOCIATED WITH EXTRAPYRAMIDAL SYMPTOMS INDUCED BY ANTIPSYCHOTIC MEDICATION - The present invention identifies genotypes associated with resistance to extrapyramidal symptoms induced by antipsychotic drugs. The present invention further identifies genotypes associated with predisposition to the onset or aggravation of extrapyramidal symptoms induced by antipsychotic drugs and use thereof for assessment of patient populations. Specifically, the present invention relates to particular polymorphisms in the RGS2 gene that are associated with resistance or susceptibility to drug-induced extrapyramidal symptoms. | 2010-01-28 |
20100021892 | Modulators of SC4MOL for treating acne or hyperseborrhea - An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of sterol-C4-methyl oxidase (SC4MOL), and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described. | 2010-01-28 |
20100021893 | Modulators of lanosterol synthetase for treating acne or hyperseborrhea - An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of lanosterol synthetase (LSS), and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described. | 2010-01-28 |
20100021894 | Nanoparticle-Based Colorimetric Detection Of Cysteine - The invention provides methods to detect cysteine which employ oligonucleotide functionalized nanoparticles. | 2010-01-28 |
20100021895 | Vectors for Inducing Homozygous Mutations and Methods of Using Same - The present invention provides vectors for inducing homozygous mutations in cells. Also provided are cells and populations of cells comprising a vector of the present invention. Further provided are methods of identifying cells with homozygous mutations. Also provided are methods of identifying agents that increase the frequency of homozygous mutations in cells. The present invention also provides methods of identifying a gene that is responsible for a recessive genetic trait. | 2010-01-28 |
20100021896 | Method for Evaluating and Comparing Immunorepertoires - Disclosed is a method for amplifying RNA and/or DNA from immune cell populations and using the amplified products to produce an immune response profile and evaluate the possible correlation between a normal or abnormal immune response and the development of a disease such as an autoimmune disease, cancer, diabetes, or heart disease. | 2010-01-28 |
20100021897 | Mycobacterium Avium Subspecies Paratuberculosis (Map) Diagnostic Test - The subject invention provides PCR primers and other nucleic acid sequences derived from | 2010-01-28 |
20100021898 | MAMMALIAN OOCYTE DEVELOPMENT COMPETENCY GRANULOSA MARKERS AND USES THEREOF - The present invention relates to the competence of oocytes for uterine implantation and development into living individuals. The invention more particularly relates to markers that are detected and measured in granulosa cells collected along with the oocytes during oocyte aspiration as it is done in assisted reproduction techniques. Markers include cytochrome P450 aromatase (CYP19A1), cell division cycle 42 (CDC42), 3-β-hydroxysteroid dehydrogenase 1 (3βHSD1), serpm peptidase inhibitor clade E member 2 (SERPINE 2), and adrenodoxm (ADX) that are detected and measured, using RT-PCR. | 2010-01-28 |
20100021899 | METHOD OF ASSAYING TARGET SUBSTANCE IN SAMPLE, APTAMER MOLECULE AND METHOD OF CONSTRUCTING THE SAME - A method for measuring a test substance whereby the test substance in a sample can be specifically measured without using an antibody against the test substance; an aptamer molecule used therefor; and a method for creating the aptamer are disclosed. An aptamer capable of hybridizing with an oligonucleotide when it is bound to a test substance, but is incapable of hybridizing with the oligonucleotide when it is not bound to the test substance, is utilized. The aptamer is brought into contact with a sample, and the aptamer bound to the test substance is brought into contact with an immobilized oligonucleotide which hybridizes with the aptamer, to bind the aptamer to a solid phase, followed by measurement of the aptamer immobilized on the solid phase. | 2010-01-28 |
20100021900 | USE OF OMENTIN 1 AND OMENTIN 2 IN THE DIAGNOSIS AND TREATMENT OF DISEASE - The present invention is directed to methods of diagnosing a disease or predicting an increased risk of a disease, such as obesity, obesity-dependent subacute inflammation, atherosclerosis, cardiovascular disease and a metabolic disease, by determining the levels of omentin 1 and 2 protein in a subject, or by determining the levels of omentin 1 and 2 gene expression in a subject. The present invention is also directed to methods of disease treatment using omentin 1 protein and omentin 2 protein. | 2010-01-28 |
20100021901 | Compositions and methods for detecting analytes - Embodiments disclosed herein relate generally to probes (e.g. self-quenching probes), methods, and kits for detecting the presence of a target analyte using probes. | 2010-01-28 |
20100021902 | Method for methylation-selective amplification - Aspects of the invention relate to a method for methylation selective amplification. The method comprising a DNA treatment, wherein cytosine is converted to uracil, uracil sulfonate or another base having a different binding behavior than cytosine, while methylated cytosine remains unchanged, and the amplification of treated DNA in the presence of at least one restriction enzyme, said enzyme digesting the amplification product derived either from converted methylated DNA or from converted unmethylated DNA during amplification. Aspects of the invention relate to a kit for performing the inventive method. Aspects of the invention relate also to the use of the inventive methods and kits. | 2010-01-28 |
20100021903 | Use of Genetic Determinants in Cardiovascular Risk Assessment - The invention generally provides compositions and methods of using a subject's genetic information for the selection of prophylactic or therapeutic agents and treatment regimens, and related methods for assaying the risk of an adverse cardiovascular event in the patient. | 2010-01-28 |
20100021904 | SHIELDED CROSS-LINKING PROBES - The present invention relates to the use of nucleic acid probes to bind to targets. In some embodiments, the probe comprises a shielded cross-linking probe. | 2010-01-28 |
20100021905 | COMPOSITIONS AND METHODS OF SELECTIVE NUCLEIC ACID ISOLATION - The invention relates to methods for isolating and/or identifying nucleic acids. The invention also provides kits for isolating and/or identifying nucleic acids. | 2010-01-28 |
20100021906 | SALIVARY BIOMARKERS FOR SJOGREN'S SYNDROME - The present invention provides for the first time the identification of salivary protein and RNA factors that can be used in the detection of primary Sjögren's Syndrome. The present invention therefore provides methods of diagnosing and providing a prognosis for Sjögren's Syndrome, by examining relevant proteins (including certain autoantigens and autoantibodies) and RNA in a patient's saliva. | 2010-01-28 |
20100021907 | METHOD OF DETECTING A PLURALITY OF NUCLEIC ACIDS - The present invention provides a method of detecting a plurality of nucleic acid samples, includes a first step of preparing a nucleic acid sample detection device, a second step of preparing 1 | 2010-01-28 |
20100021908 | NOVEL 2,5-DIKETO-L-GLUCONIC ACID REDUCTASES AND METHOD OF USE - Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated from the environment using PCR methods are described. | 2010-01-28 |
20100021909 | Concurrent Optimization In Selection of Primer and Capture Probe Sets for Nucleic Acid Analysis - Disclosed is a method of iteratively optimizing two (or more) interrelated sets of probes for the multi-step analysis of sets of designated sequences, each such sequence requiring, for conversion, at least one conversion probe (“primer”), and each converted sequence requiring, for detection, at least one capture probe. The iterative method disclosed herein for the concurrent optimization of primer and probe selection invokes fast logical string matching functions to perform a complete cross-correlation of probe sequences and target sequences. The score function assigns to each probe-target alignment a “degree of matching” score on the basis of position-weighted Hamming distance functions introduced herein. Pairs of probes in the final selection may differ in several positions, while other pairs of probes may differ in only a single position. Not all such positions are of equal importance, and a score function is introduced, reflecting the position of the mismatch within the probe sequence. | 2010-01-28 |
20100021910 | Methods and Systems for Microfluidic DNA Sample Preparation - The present invention relates to methods and systems for microfluidic DNA sample preparation. More specifically, embodiments of the present invention relate to methods and systems for the isolation of DNA from patient samples on a microfluidic device and use of the DNA for downstream processing, such as performing amplification reactions and thermal melt analysis on the microfluidic device. | 2010-01-28 |
20100021911 | PRODUCTION HOST CELL LINES - The invention concerns the field of cell culture technology. The invention describes production host cell lines comprising vector constructs comprising a DHFR expression cassette. Those cell lines have improved growth characteristics in comparison to DHFR-deficient or DHFR-reduced cell lines such as CHO DG44 and CHO DUKX-B11. The invention especially concerns two cell lines, a representative of each cell line is deposited with the DSMZ under the number DSM ACC2909 (CHOpper® Discovery) and DSM ACC2910 (CHOpper® Standard). The invention further concerns a method of producing proteins using the cells generated by the described method. | 2010-01-28 |
20100021912 | Methods of Modulating Lipid Concentrations in Eukaryotic Cells - The present invention is based on the discovery of a set of genes that are involved in lipid-droplet formation and regulation. Accordingly, the present invention provides methods of increasing or decreasing lipid concentrations in eukaryotic cells by decreasing or increasing expression of one of these genes. Increased lipid concentrations may be useful, for example, in the generation of biofuels. Decreased lipid concentration may be useful in the treatment of diseases characterized by excessive lipid storage. In addition, the invention provides methods of identifying markers of diseases characterized by excessive lipid storage. | 2010-01-28 |
20100021913 | Stimulus-Elicited Genomic Profile Markers of Alzheimer's Disease - The present invention relates to a method for diagnosing Alzheimer's Disease (AD) using PKC-elicited gene expression profiles PKC-activation elicits different genomic profiles in AD cells, as compared with control cells, which can he used to diagnose AD and individuals at risk for developing AD. | 2010-01-28 |
20100021914 | OLIGONUCLEOTIDES FOR MODULATING TARGET RNA ACTIVITY - The present invention describes oligonucleotides that bind to microRNA target sites in target RNAs, such as mRNAs. The oligonucleotides of the invention may mediate RNase H degradation of the target RNA, mediate RNAi of the target RNA or prevent microRNA regulation of the target RNA. The oligonucleotides of the invention are useful e.g. as research tools for studying microRNA:mRNA interactions and for therapeutic development. The present invention also describes methods of identifying microRNA target sites, methods of validating microRNA target sites, methods of identifying oligonucleotides of the invention and methods of modulating the activity of a target RNA using the oligonucleotides of the invention. | 2010-01-28 |
20100021915 | HIGH THROUGHPUT DNA SEQUENCING METHOD AND APPARATUS - The present invention relates to a method for high throughput nucleic acid sequencing using a multi-bead flow cell and pyrophosphate sequencing, a sequencer capable of performing this method, and a kit of the pyrophosphate sequencing reagents. | 2010-01-28 |
20100021916 | MICROSATELLITE-BASED FINGERPRINTING SYSTEM FOR SACCHARUM COMPLEX - This invention relates to | 2010-01-28 |
20100021917 | METHODS OF USING GENES AND GENETIC VARIANTS TO PREDICT OR DIAGNOSE INFLAMMATORY BOWEL DISEASE - This invention provides methods of diagnosing or predicting susceptibility to inflammatory bowel disease by determining the presence or absence of genetic variants. In one embodiment, a the invention is practiced by determining the presence or absence of NOD2 variants in an individual where the presence of NOD2 variants are indicative of susceptibility to Crohn's Disease in the individual. In another embodiment, the invention further determines the presence or absence of TLR8 variants where the presence of TLR8 variants are inflammatory bowel disease in female individuals. In another embodiment, the invention further determines the presence or absence of TR2 variant P631H where the presence of TLR2 variant P631H is indicative of susceptibility to Crohn's Disease. | 2010-01-28 |
20100021918 | METHOD FOR ASSAYING ACTION OF ANTITUMOR AGENT USING SPLICING DEFECTS AS INDEX - An object of the present invention is to provide a method, a probe, a primer, an antibody, a reagent, and a kit for assaying an action of a pladienolide derivative to a living subject. According to the present invention, there is provided a method for assaying an action of the pladienolide derivative using splicing defect as an index. | 2010-01-28 |
20100021919 | Production of Polyhydroxyalkanoates From Polyols - Recombinant processes are provided whereby additional genes are introduced into | 2010-01-28 |
20100021920 | MUTATED ABL KINASE DOMAINS - The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides. | 2010-01-28 |
20100021921 | MUTATED ABL KINASE DOMAINS - The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides. | 2010-01-28 |
20100021922 | DARK QUENCHERS FOR DONOR-ACCEPTOR ENERGY TRANSFER - The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes. | 2010-01-28 |
20100021923 | METHOD FOR THE EFFICIENCY-CORRECTED REAL-TIME QUANTIFICATION OF NUCLEIC ACIDS - The present invention concerns a method for the quantification of a target nucleic acid in a sample comprising the following steps: (i) determination of the amplification efficiency of the target nucleic acid under defined amplification conditions, (ii) amplification of the target nucleic acid contained in the sample under the same defined reaction conditions, (iii) measuring the amplification in real-time, (iv) quantification of the original amount of target nucleic acid in the sample by correction of the original amount derived from step (iii) with the aid of the determined amplification efficiency. The efficiency correction of PCR reactions according to the invention for the quantification of nucleic acids can be used for absolute quantification with the aid of an external or internal standard as well as for relative quantification compared to the expression of housekeeping genes. | 2010-01-28 |
20100021924 | Transgenic animal and methods for decreasing cardiac cell death via cardiac-specific sir2alpha overexpression - The present invention relates to a transgenic animal and methods for increasing the expression or activity of Sir2α protein. An increase in the expression of Sir2α protein prevents stress- and age-related cardiac cell death thereby facilitating the treatment of cardiac diseases or conditions associated with aging. | 2010-01-28 |
20100021925 | Isolation of nucleic acids on surfaces - New processes and equipment to isolate and purify nucleic acids on surfaces are provided. The invention focuses on processes which use surfaces, for example, porous membranes, on which the nucleic acids are immobilized in a simple manner from the sample containing the nucleic acids and can be released again by way of simple procedural steps, whereby the simple performance of the process according to the invention makes it possible to perform the processes specifically in a fully automatic manner. An additional aspect of the present invention focuses on binding the nucleic acids to an immobile phase, especially to a membrane, in such a way and manner, that they can be released without difficulty during an additional reaction stage from this phase and, if desired, can be used in other applications, such as restriction digestion, RT, PCR or RT-PCR, or in any of the suitable analyses or enzyme reactions mentioned in the disclosure. Special isolation devices are provided that can be used to carry out the processes according to the invention. | 2010-01-28 |
20100021926 | METHOD FOR RAPID DETECTION OF LYMPHATIC FILARIASIS - There is provided by this invention a specific and sensitive diagnostic method for rapid detection of lymphatic filariasis. The method employs a combination of SXP/SXP-recombinant antigen, mouse monoclonal anti-human IgG4 antibody conjugated to a detection reagent and the technique of immunochromatography. | 2010-01-28 |
20100021927 | CHOLESTEROL LOADED INSECT CELL MEMBRANES AS TEST SYSTEMS FOR ABC TRANSPORTER PROTEINS - The invention provides for a novel cholesterol loaded insect cell membrane preparation having an increased cholesterol level as compared to physiological cholesterol levels of insect cell membranes or to control insect cell membrane preparations without cholesterol loading, wherein said cholesterol loaded membrane preparation comprises an ABC transporter protein having an increased substrate transport activity due to increased cholesterol level of the membrane. The invention also relates to reagent kits comprising the preparations of the invention. The invention also relates to methods for manufacturing said preparations and methods for measuring any type of activity of the ABC transporters present in the cholesterol loaded membranes as well as studying or testing compounds and interaction of compounds and ABC transporters, in this assay systems. The invention also provides for a test system useful for testing whether ABC transporter proteins can be activated by cholesterol in an insect cell membrane. | 2010-01-28 |
20100021928 | METHODS AND KITS FOR DIAGNOSING CANCER - Methods and kits for diagnosing cancer in a subject is disclosed. The method comprises determining a level and/or activity of at least one saliva secreted marker in a saliva sample of the subject wherein an alteration in said marker with respect to an unaffected saliva sample is indicative of the cancer, with the proviso that the saliva secreted marker is not circulatory carcinoembryonic antigen (CEA). | 2010-01-28 |
20100021929 | DETECTION OF A BIOMARKER OF ABERRANT CELLS OF NEUROECTODERMAL ORIGIN IN A BODY FLUID - Assays and kits for detecting aberrant cells of neuroectodermal origin in a body fluid of an individual, comprising testing for expression of GLAST1b as a biomarker of the cells are disclosed. Intact GLAST1b and/or fragments thereof may be detected in the fluid. Alternatively, another analyte indicative of the expression of GLAST1b by the cells may be detected. The assay is particularly suitable for detecting expression of aberrant neuronal populations such as resulting from brain hypoxia. The fluid can be cerebrospinal fluid (CSF). | 2010-01-28 |
20100021930 | APPLICATION OF SURFACE PLASMON RESONANCE TECHNOLOGY TO MATERNAL SERUM SCREENING FOR CONGENITAL BIRTH DEFECTS - This invention discloses using SPR technology to simultaneously and quantitatively detect the presence of serum markers in pregnant women for the purpose of screening for congenital birth defects. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of representative antibodies used to detect the respective serum markers in pregnant women for the purpose of maternal serum screening for congenital birth defects. | 2010-01-28 |
20100021931 | Fluorescence based reporter construct for the direct detection of TGF-beta receptor activation and modulators thereof - The invention comprises a fusion protein as sensor for TGF-beta receptor activity, a method for detecting receptor activity and to screening compounds for modulators of receptor activity. The fusion protein comprises a type I TGF-beta receptor, a circularly permutated fluorescent protein moiety (cpFP) and an activation state specific receptor binding domain, binding specifically to either the activated or inactive form of the TGF-beta receptor. An activation specific interaction between the receptor and the activation state specific receptor binding domain modulates the fluorescence of the cpFP inserted in between. Thus, activation of the receptor can be detected directly by a change in fluorescence of the cpFP. | 2010-01-28 |
20100021932 | Method for use of microdialysis - Very accurate measurements of mass transfer can be made rapidly by permitting diffusion of an agent desired to be measured into or out of a small, very precisely known volume of a microdialysis probe, then rapidly pumping or flushing (“pulsing”) the probe with a known volume of fluid as a single pulse. The diffusion and pulsing may be repeated. The method, hereinafter called pulsatile microdialysis (PMD) to distinguish it from prior art continuous flow microdialysis, is useful for measurements in a number of processes, including protein binding, adsorption to binding agents such as activated charcoal, release from microemulsion drug delivery systems, determination of drug diffusion coefficients and concentrations, and for various other purposes. | 2010-01-28 |