04th week of 2014 patent applcation highlights part 39 |
Patent application number | Title | Published |
20140023950 | FUEL CELL MODULE - A fuel cell module includes a power generating unit including a cell stack having connected therein a plurality of cells that generate power by using a hydrogen-containing gas and an oxidant, and a housing accommodating the power generating unit. The housing includes an accommodation chamber having a power generating unit arrangement surface where the power generating unit is disposed and a first side wall section and accommodating the power generating unit, and an oxidant flow channel that is formed on the outside of the accommodation chamber, with the first side wall section being interposed therebetween, and allows the oxidant to pass therethrough. A through hole is formed that connects the accommodation chamber with the oxidant flow channel and serves to supply the oxidant to the cell stack. | 2014-01-23 |
20140023951 | MEDIUM-TO-LOW TEMPERATURE HIGH-EFFICIENCY ELECTROCHEMICAL CELL AND ELECTROCHEMICAL REACTION SYSTEM COMPRISING SAME - An electrochemical cell including a fuel electrode having an interface with a fuel gas, a dense ion conductor (electrolyte) and an air electrode having an interface with air (oxygen) layered in this order, the fuel electrode and the air electrode are not in contact with each other and are separated by an electrolyte, and including a functional layer having a porous structure and promoting electrochemical reactions is layered on part or all of a fuel electrode surface that is an interface with the fuel gas. The electrochemical cell allows a high-efficiency electrochemical reaction system that utilizes a gaseous hydrogen fuel that significantly lowers resistance derived from internal diffusion of a gaseous hydrogen fuel gas in a fuel electrode, and makes it possible to achieve, at a single-cell level, a generation efficiency of 40% or more even in a medium-to-low-temperature region at or below 700° C. | 2014-01-23 |
20140023952 | METHOD FOR PREPARING CATALYST LAYER BY IN-SITU SOL-GEL REACTION OF TETRAETHOXYSILANE IN NAFION IONOMER SOLUTION - Provided are a method for preparing a catalyst layer by an in-situ sol-gel reaction of tetraethoxysilane, and a fuel cell including the catalyst layer prepared thereby. Addition of silica mitigates specific adsorption of sulfonate groups contained in a Nafion ionomer on a Pt catalyst layer in a high-voltage region where the role of a catalyst predominates, resulting in improvement of ORR performance. | 2014-01-23 |
20140023953 | Proton Conducting Polymer Membrane, Membrane-Electrode Assembly Using Same, and Polymer Electrolyte Fuel Cell - Disclosed is a proton conducting polymer membrane formed by laminating a plurality of solid electrolyte membranes. This proton conducting polymer membrane is one prepared by laminating at least one layer of a solid electrolyte membrane formed by using a resin having a bis(perfluoroalkanesulfonyl)methide group in the chemical structure. This solid electrolyte membrane has a superior proton conductivity without transmitting the fuel (methanol or hydrogen). | 2014-01-23 |
20140023954 | FUEL CELL - Provided is a fuel cell including: a membrane electrode assembly ( | 2014-01-23 |
20140023955 | FUEL CELL - Provided is a fuel cell having a long product life. In a fuel cell | 2014-01-23 |
20140023956 | SILICON-BASED PROTON EXCHANGE MEMBRANE (PEM) AND METHOD OF MAKING A SILICON-BASED PEM - A silicon-based proton exchange membrane for a membrane electrode assembly comprises a silicon wafer including a back side, a front side, and a membrane region therebetween, where the membrane region includes a plurality of channels extending from openings in the front side of the silicon wafer through the membrane region to openings in the back side of the silicon wafer. Walls of the channels include active sites to which a molecular species may be attached. Each of the front side and the back side of the silicon wafer includes a porous capping layer thereon. The capping layer comprises a plurality of through-thickness apertures contiguous with at least a portion of the channels of the membrane region. | 2014-01-23 |
20140023957 | LAYER STRUCTURE AND USE THEREOF TO FORM A CERAMIC LAYER STRUCTURE BETWEEN AN INTERCONNECT AND A CATHODE OF A HIGH-TEMPERATURE FUEL CELL - The invention relates to a layer structure which is formed between an interconnect and a cathode of a solid oxide fuel cell and can be used for forming a ceramic layer structure between an interconnect and a cathode. In this respect, the interconnect comprises a metal alloy containing chromium. The object of the present invention is to provide a layer structure between an interconnect and a cathode of a solid oxide fuel cell with which a good protective function (from corrosion and from chromium vaporization), a high electrical conductivity and also a good thermal expansion behavior adapted to the materials of an interconnect and of a cathode can be achieved. The layer structure in the green state is formed by a powdery spinel as well as at least one of the below-named metal oxides CuO, NiO, CoO | 2014-01-23 |
20140023958 | METHOD FOR MANUFACTURING ELECTRODE FOR FUEL CELL COMPRISING NANOCARBON AND CORE-SHELL-STRUCTURED PLATINUM-CARBON COMPOSITE AND THE ELECTRODE FOR FUEL CELL MANUFACTURED BY THE SAME - The present subject matter provides a method of manufacturing an electrode for a fuel cell, in which nanocarbons are grown on the surface of a substrate for a fuel cell using a process of simultaneously gasifying a platinum precursor and a carbon precursor, and simultaneously core-shell-structured platinum-carbon composite catalyst particles are highly dispersed between nanocarbons The subject matter also provides an electrode for a fuel cell, manufactured by the method. This method is advantageous in that an electrode for a fuel cell having remarkably improved electrochemical performance and durability can be manufactured by a simple process. | 2014-01-23 |
20140023959 | IMAGING MEMBER LAYERS - The presently disclosed embodiments relate generally to layers that are useful in imaging apparatus members and components, for use in electrophotographic, including digital printing, apparatuses. More particularly, the embodiments pertain to an improved electrophotographic imaging member comprising an overcoat layer which prevents image quality issues such as deletion. The overcoat layer comprises a phenolic triarylamine charge transport molecule, an aminoplast and a triamino triphenyl compound. | 2014-01-23 |
20140023960 | ELECTROPHOTOGRAPHIC MEMBER, METHOD FOR PRODUCING THE SAME, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS - An electrophotographic member including an electrically conductive substrate and an electrically conductive resin layer corresponding to a surface layer. The resin layer includes electrically conductive particles and a binder resin. The binder resin is a polymer in which a polymer chain having at least one unit selected from the group consisting of units represented by the following formulas (1) and (2) and at least one unit selected from the group consisting of units represented by the following formulas (3) and (4) is crosslinked by at least one organopolysiloxane chain selected from the group consisting of structures represented by the following formulas (5) and (6): | 2014-01-23 |
20140023961 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER,PROCESS CARTRIDGE, ELECTROPHOTOGRAPHIC APPARATUS AND METHOD OF MANUFACTURING THE ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER - A charge-transporting layer, which is a surface layer of an electrophotographic photosensitive member, has a matrix-domain structure having a matrix containing constituent β (a polycarbonate resin having a predetermined repeating structural unit) and a charge-transporting substance, and a domain containing constituent α (a polycarbonate resin having a repeating structural unit having a predetermined siloxane moiety). | 2014-01-23 |
20140023962 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, ELECTROPHOTOGRAPHIC APPARATUS AND METHOD OF MANUFACTURING THE ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER - A charge-transporting layer, which is a surface layer of an electrophotographic photosensitive member, has a matrix-domain structure having a matrix containing constituent β (a polyester resin having a predetermined repeating structural unit) and a charge-transporting substance, and a domain containing constituent α (a polycarbonate resin having a repeating structural unit having a predetermined siloxane moiety). | 2014-01-23 |
20140023963 | Organic Photoconductors with Latex Polymer Overcoat Layers - An organic photoconductor includes: a conductive substrate; a charge generation layer on the conductive substrate; and a charge transport layer on the charge generation layer. An overcoat layer is formed on the charge transport layer. The overcoat layer is a latex polymer in which a charge transport material is dispersed. | 2014-01-23 |
20140023964 | TONER SET, IMAGE FORMING APPARATUS, AND IMAGE FORMING METHOD - Provided is a toner set including at least a first brilliant toner that contains a brilliant pigment, and a second brilliant toner that contains a brilliant pigment and exhibits a different color from the first brilliant toner. | 2014-01-23 |
20140023965 | TONER, DEVELOPMENT AGENT, AND IMAGE FORMING APPARATUS - Toner contains a binder resin and a colorant, wherein the binder resin contains a resin having a polyhydroxy carboxylic acid skeleton, wherein the toner has a half effusion temperature of from 80° C. to 120° C. as measured by a temperature rising method using a flow tester. | 2014-01-23 |
20140023966 | CARRIER FOR DEVELOPING ELECTROSTATIC LATENT IMAGE, AND ELECTROSTATIC LATENT IMAGE DEVELOPER - A carrier for developing electrostatic latent images includes a core material; and a covering layer formed of a resin comprising an electroconductive particulate material, overlying the core material, wherein the covering layer includes the electroconductive particulate material in an amount of from 58 to 73% by weight and has a resistivity of from 6.6 to 8.6 Ωcm, and wherein the carrier has a high-brightness contrast part at an areal ratio less than 1% and 40 to 90% based on total area thereof at an acceleration voltage of 0.8 KV and 2.0 KV, respectively in an FE-SEM reflection electron image of the surface thereof. | 2014-01-23 |
20140023967 | COLOR IMAGE FORMING METHOD AND COLOR IMAGE FORMING APPARATUS - A color image forming method, including: forming electrostatic latent image on electrostatic latent image bearing member; developing the image to form visible image with at least two toners containing releasing agent and selected from black, magenta, cyan and yellow toners; transferring the visible image to recording medium; fixing the transferred image thereon with fixing member having no releasing agent on surface thereof; and forming overcoat layer on the fixed image by polymerizing overcoat composition, wherein when lightness-L1, chromaticity-a1 and so chromaticity-b1 according to L*a*b* color system of the fixed image formed with the at least two toners and lightness-L2, chromaticity-a2 and chromaticity-b2 of the fixed image after the overcoat composition is dropped at 0.4 mg/cm | 2014-01-23 |
20140023968 | RESIST PATTERN-FORMING METHOD, RESIST PATTERN-FORMING RADIATION-SENSITIVE RESIN COMPOSITION, AND RESIST FILM - A resist pattern-forming method includes providing a resist film having a surface free energy of 30 to 40 mN/m on a substrate using a radiation-sensitive resin composition. The resist film is exposed by applying radiation via a mask. The exposed resist film is developed. It is preferable that the exposing of the resist film includes exposing the resist film via an immersion liquid that is provided over the resist film | 2014-01-23 |
20140023969 | POSITIVE PHOTORESIST COMPOSITION, COATING FILM THEREOF, AND NOVOLAC PHENOL RESIN - A positive photoresist composition includes 3 to 80 parts by mass of a novolac phenol resin (B) relative to 100 parts by mass of a cresol novolac resin (A). The novolac phenol resin (B) has a repeating structural unit represented by formula (1) | 2014-01-23 |
20140023970 | Photo-Patternable and Developable Silsesquioxane Resins for Use in Device Fabrication - A coatable resin solution capable of forming a coating when applied to the surface of a substrate that is photo-patternable and developable as a dielectric material upon exposure to ultraviolet radiation is provided. The resin solution comprises a silsequioxane-based (SSQ-based) resin, at least one initiator, and an organic solvent. The SSQ-based resin includes both a hydride component and at least one photo-curable component. The resulting coating exhibits a dielectric constant that is less than or equal to about 3.5. | 2014-01-23 |
20140023971 | PHOTORESIST COMPOSITION AND METHOD FOR PRODUCING PHOTORESIST PATTERN - A photoresist composition comprising | 2014-01-23 |
20140023972 | Data Process for E-Beam Lithography - The present disclosure provides a dithering method of increasing wafer throughput by an electron beam lithography system. The dithering method generates an edge map from a vertex map. The vertex map is generated from an integrated circuit design layout (such as an original pattern bitmap). A gray map (also referred to as a pattern gray map) is also generated from the integrated circuit design layout. By combining the edge map with the gray map, a modified integrated circuit design layout (modified pattern bitmap) is generated for use by the electron beam lithography system. | 2014-01-23 |
20140023973 | EXTREME ULTRAVIOLET/SOFT X-RAY LASER NANO-SCALE PATTERNING USING THE DEMAGNIFIED TALBOT EFFECT - An apparatus and method for nanopatterning of substrates using the demagnified Talbot effect, wherein: (a) large arrays of nanostructures can rapidly be printed; (b) short extreme ultraviolet wavelengths permits sub-100 nm spatial resolution; (c) the de-magnification factor can be continuously adjusted, that is, continuously scaled; (d) the patterning is the effect of the collective diffraction of numerous tiled units that constitute the periodic array, giving rise to error resistance such that a defect in one unit is averaged over the area of the mask and the print does not show any defects; (e) the Talbot mask does not wear out since the method is non-contact; and (f) the feature sizes on the mask do not have to be as small as the feature sizes desired on the target, are described. The apparatus includes a source of coherent radiation having a chosen wavelength directed onto a focusing optic, the reflected converging light passing through a Talbot mask and impinging on a target substrate. | 2014-01-23 |
20140023974 | SPIRAL DESIGN GRAPHENE NANORIBBON - Graphene nanoribbons and methods for fabricating graphene nanoribbons, particularly those with long lengths, are provided. In one embodiment, a method ( | 2014-01-23 |
20140023975 | PROCESS FOR ENABLING CARBON-CAPTURE FROM CONVENTIONAL STEAM METHANE REFORMER - A process of producing a feed form a solid electrolyte oxygen separator and combusting the feed in a steam methane reforming furnace to produce a flue gas. | 2014-01-23 |
20140023976 | COMBUSTION BLOWER CONTROL FOR MODULATING FURNACE - A furnace includes a combustion blower and one or more pressure switches. In some cases, the one or more pressure switches may be used to calculate one or more operating points for the combustion blower. Additional operating points may be calculated by interpolation and/or extrapolation, as appropriate. The furnace may temporarily alter these operating points as necessary to keep the furnace safely operating in response to minor and/or transient changes in the operating conditions of the furnace. | 2014-01-23 |
20140023977 | THERMAL PROCESSES OF REDUCING FOODBORNE PATHOGENS IN BAGGED FOOD PRODUCTS - A heating assembly designed for reducing foodborne pathogens in bagged food products comprises a heat insulated treatment chamber, multiple high temperature natural gas fired furnaces, multiple insulated ductworks further comprising multiple sets of intake ducts and multiple sets of exhaust ducts, a cooling system that allows air to be controlled and supplied into the treatment chamber, multiple temperature sensor probes placed in the treatment chamber, the natural gas fired furnaces, and the bagged food products, a digital control system, and a computer program that monitors the temperature of each probe. A specially designed racking system with multiple levels allows multiple dry bags containing the food products to be stacked in a manner that rapidly and uniformly heat the food products. | 2014-01-23 |
20140023978 | DRIVE DEVICE AND THE CORRESPONDING ROTARY KILN - This drive device ( | 2014-01-23 |
20140023979 | REGENERATION OF AMELOBLAST CELLS AND DENTAL ENAMEL IN VIVO - A first aspect of the invention is related to a method for treating a subject's tooth that needs regeneration of dental enamel tissue and/or ameloblast cells. This method includes exposing at least a portion of crown, root canal or periapical tissue of the tooth and administering an enamel material in an amount sufficient to promote the regeneration of dental enamel tissue and/or ameloblast cells such that at least a portion of the exposed crown, root canal or periapical tissue is in contact with the enamel material. The invention is also related to a kits, compositions, and devices which can be used for the purposes of the present invention. | 2014-01-23 |
20140023980 | TREATMENT PROGRESS TRACKING AND RECALIBRATION - The present invention relates to systems and methods of developing and tracking delivery and patient progression through an orthodontic treatment plan. One method includes identifying deviations from an orthodontic treatment plan, including receiving a digital representation of an actual arrangement of a patient's teeth after an orthodontic treatment plan has begun for the patient and prior to completion of the orthodontic treatment plan. The method further includes comparing the actual arrangement to a pre-determined planned arrangement to determine if the actual arrangement substantially deviates from the planned arrangement, the comparing comprising matching teeth from a previously segmented model to a surface of an unsegmented representation of the actual arrangement; and calculating one or more positional differences between the actual and planned arrangements of at least some of the corresponding teeth. | 2014-01-23 |
20140023981 | Orthodontic Bracket - An orthodontic bracket for attaching an archwire to a tooth including a body including a bonding base for attachment to the tooth, the body having an occlusal-gingivally extending opening, a lingual vertical slot, a pair of laterally spaced gingival tie wings and a pair of laterally spaced occlusal tie wings, the gingival and occlusal tie wings projecting from a labial surface of the body. An archwire slot is provided extending mesiodistally across the body and between the gingival and occlusal tie wings at opposed medial and distal sides of the body to accommodate the archwire. A locking shutter including at least one resilient arm member at one end and a retaining portion at another end is provided such that the locking shutter moveable between an open position in which placement and removal of the archwire is facilitated and a closed position in which placement and removal of the archwire is inhibited. There is further provided a retaining groove formed in an occlusal wall of the gingival tie wings for releasably retaining a retaining portion of the locking shutter in the closed position and, at least one blocker for preventing movement of the archwire out of the archwire slot and into the retaining groove. In addition, a broader locking shutter is possible that prevents a sharp bend in the archwire to prevent notching or bonding of the archwire during early tooth movement and sliding of teeth during mid-term treatment tooth movement. | 2014-01-23 |
20140023982 | SKELETAL ANCHORAGE DEVICE - The skeletal anchorage device according to the invention for attaching at least one orthodontic element to be used for orthodontic treatment comprises an anchorage element ( | 2014-01-23 |
20140023983 | ELECTRO-ORTHODONTIC DEVICE - An electro-orthodontic appliance is provided that helps accelerate orthodontic tooth movement through the application of a controlled electrical current to gum and teeth, thus stimulating osteogenesis. | 2014-01-23 |
20140023984 | DENTAL CHARTING SYSTEM - A dental charting system having a control device configured to be held by a user or which is mounted to another device held by a user and the control device including one or more movement sensors for sensing movement of the control device in space and generating representative movement signals. A gesture processing module is provided to receive and process the movement signals to detect the occurrence of a gesture event from a set of predetermined gesture events, and which generates representative gesture control signals. A dental charting application program is also provided and runs on a host device and which provides a graphic user interface on a display associated with the host device for interacting with the application program, the application program being configured to receive and process the gesture control signals to enable interaction with the graphic user interface by the user via hand gesture movements of the control device. | 2014-01-23 |
20140023985 | NEEDLELESS INJECTOR WAND ASSEMBLY - A needleless injector syringe includes a tubular barrel containing a first chamber for receiving a liquid, a nozzle on a front end of the barrel, a piston which drives a plunger for discharging the liquid through the nozzle, a second chamber in which the piston slides, a third chamber in fluid communication with the second chamber for receiving gas from said second chamber during forward movement of the piston, and for carrying gas to the second chamber to cause the piston to retract, and a breach plug closing a rear end of the barrel for directing gas under pressure alternately against the rear end of the piston and to the third chamber for driving the piston between the discharge position and a retracted position. | 2014-01-23 |
20140023986 | MOTORIZED SYRINGE FOR USE WITH TWO TYPES OF DENTAL ANESTHETIC SOLUTION-CONTAINING CARTRIDGES - A motorized syringe for use with two types of dental anesthetic solution-filled cartridges, having a plunger plug in the 1.8 ml cartridge pushed by a push rod by a length required to push a plunger plug in the 1.0 ml cartridge. The syringe includes a cartridge holder for use with 1.0 ml and 1.8 ml cartridges, the push rod having a 1.0 ml position and a 1.8 ml position drawn back from the 1.0 ml position so that push rod movement can end at a common terminal position for both, a sleeve adapted to receive the push rod rear end when pushed back from the common terminal position, and to be not interfered with by the push rod's rear end when it is in the 1.0 ml position, the sleeve being pushed rearward with the push rod's rear end when pushed back to the 1.8 ml position. | 2014-01-23 |
20140023987 | ADJUSTABLE SUCTION APPARATUS FOR DENTAL ASPIRATOR - An aspirator tip for a dental aspirator comprising: an elongated hollow tube comprising a first end and a second end, the first end configured to connect to a dental aspirator unit to provide suction to the second end of the elongated hollow tube, the second end configured to be inserted into an oral cavity of a patient, an opening in a portion of the elongated hollow tube between the first end and the second end of the elongated hollow tube, a gate configured to be inserted into the opening, and an actuator configured for actuation by a single digit (e.g., finger or thumb) to insert the gate into the opening to at least partially block an airway through the elongated hollow tube. | 2014-01-23 |
20140023988 | OSCILLATING BLADE FOR CUTTING PERIODONTAL LIGAMENTS AND LUXATING TOOTH ROOTS - A cutting blade having a pair of razor-sharp cutting edges and adapted to be oscillated back and forth in order to cut through the periodontal ligaments which surround a tooth root of a patient during dental surgery so that the root or a portion of a tooth root can be removed from the patient's jawbone. The cutting blade has a connecting shaft at one end by which the blade can be coupled to the driver head of an oscillating dental handpiece. Located opposite the connecting shaft is a cutting end having a tissue debris transfer canal at the bottom or inside thereof and a smooth tissue gliding surface at the top or outside. A positioning collar surrounds the connecting shaft to provide to the oral surgeon a visual indication of the alignment of the pair of cutting edges of the cutting blade relative to the tissue to be cut. | 2014-01-23 |
20140023989 | DENTURE SYSTEM, ENGAGEMENT PIECE USED FOR DENTURE SYSTEM, METHOD FOR PRODUCING DENTURE BASE AND DENTURE - A denture system comprising: abutments coupled to the fixtures; and a denture to be detachably attached to the abutments, the denture including: a denture base; an artificial tooth supported by the denture base; a plurality of engagement piece members defining slits extending in the up-down direction; and a lid portion connecting end portions of the engagement piece members as well as closing one end of fitting hole in the up-down direction and covering an entire surface of the tip of the abutment, wherein the lid portion configures a part of the denture base, the piece member has a first surface and a second surface, and a grooved allowance portion is provided allowing the piece member to deform and spread in direction from the first surface toward the second surface. | 2014-01-23 |
20140023990 | SELF-OSTEOTOMIZING BONE IMPLANT AND RELATED METHOD - A bone implant includes a head and a core body extending from the head to a tip. An osteotomy blade extends outwardly from at least a portion of the core body to form a spiral thread. The implant, and particularly the osteotomy blade, is configured to self-osteotomize and direct cut bone into channels to facilitate bone growth and grafting and integration of the implant to the bone. | 2014-01-23 |
20140023991 | Dental Implant and Method of Use with Improved Maxillary Stability - A dental implant apparatus and method of use which has a central conduit and a plurality of apical apertures through which fluid bone-grafting material may be extruded. A resorbable membrane surrounds the apical end of the apparatus and unfurls as bone-grafting material exits the apertures, thereby holding the fluid in close proximity to the implant. | 2014-01-23 |
20140023992 | POROUS METAL DENTAL IMPLANT - A porous metal augment is sized for use in mandibular or maxillar bone. The porous metal material of the augment facilitates and promotes ingrowth of the surrounding bone into the porous metal structure, thereby rebuilding a suitable foundation for affixation of dental implants. A non-porous core or insert can be embedded within the porous metal body of the augment, and can be made of a material suitable for firm threaded fixation of dental implants thereto. For example, the metal core can be formed of a titanium structure that has sufficient strength and resiliency to form a firm and long lasting threaded connection with a threaded stem of a dental implant. | 2014-01-23 |
20140023993 | APPARATUS AND METHODS FOR MULTIPHOTON MICROSCOPY - A multiphoton microscope is provided. The microscope includes: an excitation source for providing an optical excitation beam at an excitation wavelength λ; a scanner for scanning the excitation beam on a sample; an objective for irradiating the sample with the excitation beam scanned by the scanner and for collecting an emission beam from the sample; a first detector for detecting a plurality of multiphoton signals; and an emission light path allowing transmission from the objective to the first detector a wavelength band limited to greater than or equal to λ/2 and less than λ, wherein the plurality of multiphoton signals have wavelengths within the wavelength band; wherein the plurality of multiphoton signals comprises a first multiphoton signal and a second multiphoton signal of different types. Fast image capture rate multiphoton microscopes for in vivo imaging, as well as photothermolysis methods using the microscopes are also provided. | 2014-01-23 |
20140023994 | ORAL APPLIANCE FOR DELIVERING A MEDICAMENT - An oral appliance is provided for delivering a medicament to at least a portion of teeth and/or soft tissue areas inside a mouth, the oral appliance comprising an interior surface having a porous material disposed on at least a portion of the interior surface of the oral appliance, the porous material containing a medicament and the interior surface being formed to fit contours of at least the portion of the teeth and/or soft tissue areas inside the mouth and being capable of supporting and holding the porous material in contact with at least the portion of the teeth and/or soft tissue areas inside the mouth to deliver the medicament. | 2014-01-23 |
20140023995 | WIRELESS IMMERSIVE SIMULATION SYSTEM - Computer-based systems provide a wireless, high fidelity, real-time video and audio immersive environment for multiple users. A user may be equipped with a head mounted display device which wirelessly receives real-time video signals transmitted by a radio transceiver linked to a computer that generates the real-time video images. Aspects include body, arm and leg motion and orientation sensors in wireless communication with a radio transceiver linked with a computer. Video images may be generated using a portable array of user dedicated computers controlled by a single computer that is controlled by an operator. | 2014-01-23 |
20140023996 | Three Dimensional Model Objects - Embodiments of the present invention provide a three dimensional model object, a method of producing the three dimensional model object, and a kit comprising the three dimensional model object and a scaled measurement device. The method in accordance with the present invention includes surveying a constructed structure which is georeferenceable in the real world, obtaining spatial data associated with the constructed structure, generating a digital three dimensional model of the constructed structure in a computer, and producing a physical model object with accurately surveyed as-built data of the constructed structure. The physical model object of the constructed structure can incorporate, on its surface, surveyed and measured useful real world intelligence, such as dimensions, georeference data, or orientation, associated with the constructed structure. | 2014-01-23 |
20140023997 | COMPUTER-IMPLEMENTED SYSTEM AND METHOD FOR ENGAGING AND EDUCATING BUSINESS-TO-BUSINESS SALES PARTNERS ON PRODUCTS AND SERVICES - A computer-implemented method for engaging and dedicating sales partners is provided. In exemplary embodiments, the method may comprise, transmitting educational material to a user, the educational material comprising information related to at least one of a product and a service of an administrator; transmitting a test to the user and receiving test answers from the user; comparing the test answers with a predetermined set of correct answers, calculating a user proficiency, and determining if the user proficiency meets a predetermined standard; generating an alert notifying the administrator whether the user proficiency meets the predetermined standard and transmitting the alert to the administrator; transmitting secondary educational material to a user if the user proficiency does not meet the predetermined standard; and allocating a proficiency designation to the user if the user proficiency meets the predetermined standard and storing the proficiency designation in a database. | 2014-01-23 |
20140023998 | METHOD AND APPARATUS FOR UTILIZING CONTROL POINTS TO MANAGE A USER TO A DESIRED STATE - The system is an interactive control system that uses multiple control points to manage a user toward a desired state through coaching, feedback, and feed-forward mechanisms. They system uses push and pull from a user to dynamically determine which control points to utilize and emphasize to guide the user to a desired state. The system creates Topics that are generated out of Content Elements. These topics are referenced by Rules and are arranged in a queue so that a planned succession of Topics can be presented proactively to a user in a prioritized and logical manner to guide the user to a desired state. The Rules include Dynamic Rules that allow real time modification of the queue to present Topics relevant to user state and progress toward the desired state. | 2014-01-23 |
20140023999 | DETECTION AND FEEDBACK OF INFORMATION ASSOCIATED WITH EXECUTIVE FUNCTION - An example includes a neurosensing and feedback device to detect mental states and alert the wearer, such as in real-time. In an example, neural activity is detected by sensors that measure frequency, amplitude, synchrony, sequence and site of brain activity. These measurements can be compared to neural signatures and patterns shown to be correlated to neuropsychological conditions and disorders. When these measurements indicate an undesirable state the wearer is alerted via visual, audible or tactile means designed to be highly effective at alerting the wearer and allowing them to adjust their brain activity. Executive function, known to be crucial for school readiness, academic achievement and successful life outcomes, is the chief state to be detected, trained and supported. The device is designed to be used during primary activities, e.g. reading and listening, and to not require third party intervention during primary use. | 2014-01-23 |
20140024000 | MENTOR SERVICE TERMINAL, MENTOR SERVICE METHOD, AND NON-TRANSITORY COMPUTER READABLE RECORDING MEDIUM STORING THE METHOD - A mentor service terminal including an input unit, a display unit, and a controller, a mentor service method, and a non-transitory computer readable recording medium storing the method are provided. Users can be allowed to give questions to themselves for their own life, and led to find answers for the questions and roots of their life. On the basis of theses, the users have chance to find solutions to live their successful and happy lives. | 2014-01-23 |
20140024001 | ORAL DEVICE - An oral device ( | 2014-01-23 |
20140024002 | METHOD AND APPARATUS FOR AN ORTHOPEDIC FIXATION SYSTEM - An orthopedic fixation system includes a sterile packaged implant kit and a sterile packaged instrument kit. The sterile packaged implant kit includes at least one surgical implant, an insertion device, and an implant package adapted to receive the at least one surgical implant and the insertion device therein. The implant package maintains the at least one surgical implant and the insertion device sterile after sterilization of the sterile packaged implant kit. The sterile packaged instrument kit includes one or more instruments necessary to use the sterile packaged implant kit and an instrument package adapted to receive the one or more instruments therein. The instrument package maintains the one or more instruments sterile after sterilization of the sterile packaged instrument kit. | 2014-01-23 |
20140024003 | TOOTH MODEL USED FOR DENTAL TRAINING AND METHOD OF MANUFACTURING SAME - Provided are a tooth model having parts corresponding to tartar formed uniformly and a method of manufacturing the tooth model. A tooth model ( | 2014-01-23 |
20140024004 | MEDICAL TRAINING DEVICE AND METHOD - The present invention relates to a medical training device, preferably being shaped as at least a part of a human or animal skull. The training device comprises at least three elements: an element imitating the skull, an element imitating soft tissue, typically being a brain or a part thereof, and an element imitating a meninge or part thereof, preferably being the dura mater. The invention also relates to a method of training surgeons. | 2014-01-23 |
20140024005 | Multi-Platform Learning Environment - A multi-platform learning environment is provided. The environment supports instructor/expert-facilitated learning in multiple modalities, tracks learners, and displays content that is relevant to a particular course, learning need and/or platform (e.g., personal computer, mobile device or tablet). The environment includes a learning interface that integrates various training into a single component that supports multiple training modalities. Related apparatus, systems, techniques and articles are also described. | 2014-01-23 |
20140024006 | QUESTION SETTING APPARATUS AND METHOD - A question setting apparatus is disclosed, including a processor and a storage part. The storage stores problem information which maintains problem data including a problem and a correct answer of the problem included in a test sent to students, and student answer information which maintains answer data and a correct/incorrect answer determination result for each of the students. The processor processes test operations of referring to the problem information, sending the problem data to the student terminals, receiving the answer data from the student terminals in a given time for the test, and recording the answer data in the student answer information. The processor processes a progress display. A progress state is displayed in the given time and indicates an answer state of the problem data based on the correct/incorrect answer determination result. A display instruction is sent to the student terminals to stop the test. | 2014-01-23 |
20140024007 | PORTAL/DASHBOARD INTERFACE FOR TEACHER/STUDENT RELATIONSHIP MANAGEMENT AND TRADITION PRESERVATION WEBSITE - A virtual studio for managing the relationship between a teacher and their students where the teacher uses multiple customizable portals to communicate with and manage their students. The teacher is able to customize the portal on a per student basis. The virtual studio also enables the teacher to promote students to perform other roles in the studio and includes a comprehensive invoicing feature for billing purposes. The virtual studio also helps teachers share their lessons with other virtual studios. | 2014-01-23 |
20140024008 | STANDARDS-BASED PERSONALIZED LEARNING ASSESSMENTS FOR SCHOOL AND HOME - Assessment devices, and teaching methods involving the use of the assessment devices, are disclosed. The assessment devices include iterative homework, quizzes, and/or tests, each of which allows for individual students to answer an initial question, and, based on the answer to that question, the next question will be harder or easier. The assessment devices can be administered to the students in print form, or electronically, such as on a computer or a personal digital assistant. Once the data is collated, students can be screened based on their ability to grasp all or a portion of the questions in a given test, and separated into groups based on their understanding of the subject matter. Teachers can then individually teach the different groups of students, ideally using lesson plans designed to work in tandem with the assessment devices, based on the students' grasp of the material. | 2014-01-23 |
20140024009 | SYSTEMS AND METHODS FOR PROVIDING A PERSONALIZED EDUCATIONAL PLATFORM - The disclosed technology, in certain embodiments, generates customized assessments based on educational content to match the needs and learning styles of individual learners. The educational content may be identified and provided to a user based on user profile information such as grade, age, and/or education level. Moreover, the disclosed technology can adapt the educational content for an individual user based on a preferred learning style of the user. | 2014-01-23 |
20140024010 | METHOD FOR PRODUCING ARTIFICIAL SKIN MODEL, AND ARTIFICIAL SKIN MODEL - Provided is a novel method capable of producing an artificial skin model. A method for producing an artificial skin model includes: providing coated cells ( | 2014-01-23 |
20140024011 | Method for Preparing Adipose Tissue - This disclosure presents methodologies for processing, cryogenic storage, retrieval and preparation of a tissue for transplantation. As such, the methods provide a system by which tissue for transplantation can be reliably and safely processed and stored for an extended period of time until the tissue is desired to be used. | 2014-01-23 |
20140024012 | EXTRA-CAPILLARY FLUID CYCLING SYSTEM AND METHOD FOR A CELL CULTURE DEVICE - An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also located in the housing, the second flexible reservoir being in fluid communication with a pressure source. A sensor plate is movably disposed in the housing between the extra-capillary reservoir and the second reservoir, wherein the second reservoir is pressurized to move the sensor plate in relation to the extra-capillary reservoir to cause fluid cycling and maintain fluid volumes in the cell growth chamber. | 2014-01-23 |
20140024013 | Isolation, Cloning and Characterization of New Adeno-Associated Virus (AAV) Serotypes - The present invention provides new adeno-associated virus (AAV) viruses and vectors, and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV vectors and particles. | 2014-01-23 |
20140024014 | PRIMER SET, METHOD AND KIT FOR DETECTING PATHOGEN IN ANIMALS OR PLANTS - The invention provides a method for rapidly detecting a pathogen in animals or plants comprising using a specific primer set and nucleic acid in a sample to carry on a loop-mediated isothermal amplification. If at least one amplification occurs, the sample comprises the pathogen. The invention also provides a primer set, probe and kit for detecting a pathogen in animals or plants. | 2014-01-23 |
20140024015 | Boone Cardiovirus - The invention provides an isolated Boone cardiovirus, Boone cardiovirus polypeptides, polynucleotides and antibodies specific for Boone cardiovirus polypeptides. Also provided are methods for detection of Boone cardiovirus. | 2014-01-23 |
20140024016 | LATERAL FLOW ASSAYS USING TWO DIMENSIONAL FEATURES - The present invention relates to novel lateral flow devices using two dimensional features, preferably, uniform two dimensional test and control features, to provide flow control information, to function as an internal control and/or to provide internal calibration information for the test device. The present invention also relates to methods for using the lateral flow devices to provide flow control information, to function as an internal control and/or to provide internal calibration information for the test device. | 2014-01-23 |
20140024017 | IDENTIFICATION OF A NOVEL HUMAN POLYOMAVIRUS (IPPyV) AND APPLICATIONS - The invention relates to the identification of a novel human polyomavirus species (designated IPPyV) and applications derived from the identified features and properties of this virus. The IPPy virus species of the invention qualifies as a human virus, in view of the fact that it is capable of infecting a human host. Having identified a novel human polyomavirus species, IPPyV, the inventors have been able to propose means for the detection of exposure or infection by such a virus, especially detection in a biological sample previously obtained from a human host. The invention also concerns means suitable for obtaining an immune response in a host with a view to prevent the onset or the development of an infection with an IPPyV. | 2014-01-23 |
20140024018 | METHOD FOR THE PROGNOSIS OF PROGRESSION OF THE HIV DISEASE - An in vitro method for the prognosis of progression of an HIV-1 infection in a patient infected with an HIV-1 virus, comprising the steps of: a) measuring the level of antibodies directed against the 3S peptide of SEQ ID NO 2 in a sample collected from the said patient, b) comparing the level of anti-3S antibodies measured at step a) with a reference value of anti-3S antibody level that is indicative of the progression of the HIV-1 infection. | 2014-01-23 |
20140024019 | Methods and Means for Monitoring Disruption of Tissue Homeostasis in the Total Body - The invention relates to the field of medical diagnostics. Provided are methods and kits for determining the health status of a subject, for early detection of tissue damage, for early diagnosis and monitoring of a disease, and/or for evaluation of treatment effectiveness in a subject using circulating tissue macrophages (CTM) as a mirror of disrupted tissue homeostasis and disease. | 2014-01-23 |
20140024020 | OPTICAL ANALYSIS DEVICE, OPTICAL ANALYSIS METHOD AND COMPUTER PROGRAM FOR OPTICAL ANALYSIS USING SINGLE LIGHT-EMITTING PARTICLE DETECTION - There is provided a structure to reduce the size of light intensity data in the scanning molecule counting method using an optical measurement with a confocal microscope or a multiphoton microscope. In the inventive optical analysis technique of detecting light of a light-emitting particle in a sample solution, time series light intensity data of light from a light detection region detected with moving the position of the light detection region of the microscope in the sample solution is generated, and a signal of a light-emitting particle individually is detected in the time series light intensity data. In that case, regions where no signal indicating light of light-emitting particles exist in the time series light intensity data is removed from the time series light intensity data. | 2014-01-23 |
20140024021 | COMPOSITIONS, REACTION MIXTURES AND METHODS FOR DETECTING NUCLEIC ACIDS FROM MULTIPLE TYPES OF HUMAN PAPILLOMAVIRUS. - Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products are disclosed. | 2014-01-23 |
20140024022 | CELL TREATMENT SOLUTION AND METHOD OF PREPARING STAINED CELL SUSPENSION FOR A MEASUREMENT OF NUCLEAR DNA BY FLOW CYTOMETRY - A cell treatment solution and a method that is used for preparing a stained cell suspension that is provided to a measurement of nuclear DNA by flow cytometry. The cell treatment solution may include a surfactant, RNase, and a fluorescent dye. The surfactant may include, for example, a non-ionic surfactant, a zwitterionic surfactant, an anionic surfactant, and/or a cationic surfactant. In one method of the presently disclosed subject matter, stained cell suspension that is provided to a measurement of nuclear DNA by flow cytometry is prepared. The method may include adding a tissue sample to a cell treatment solution including a surfactant, RNase, and fluorescent dye, disaggregating the tissue sample, and filtering the disaggregated tissue sample. Another method of the presently disclosed subject matter includes disaggregating a tissue sample, preparing cell suspension by filtering the disaggregated tissue sample, and adding a cell treatment solution including a surfactant, RNase, and fluorescent dye. | 2014-01-23 |
20140024023 | DROPLET GENERATION SYSTEM WITH FEATURES FOR SAMPLE POSITIONING - System, including methods and apparatus, for forming droplets of an emulsion. The system may include a channel junction at which a stream of sample fluid is divided into droplets by a dividing flow of carrier fluid. The system also may include one or more features configured to position sample fluid for reduced contact between the sample fluid and one or more surface regions of the channel junction, which may improve the consistency of droplet formation. In exemplary embodiments, sample fluid may be positioned by a step member produced by an increase in channel depth, and/or by directing flow of carrier fluid to form a barrier layer between sample fluid and a wall region, such as a ceiling region or floor region, of a channel network. | 2014-01-23 |
20140024024 | METHODS OF DETECTING DNA, RNA AND PROTEIN IN BIOLOGICAL SAMPLES - Novel methods of probing multiple targets in a biological sample are provide whereby the targets are DNA, RNA and protein. The method comprises subjecting the sample to an in situ hybridization reaction using a labeled nucleic acid probe that binds an RNA target, observing a signal, and optionally removing the signal. The method further comprises an antigen retrieval protocol, observing a signal, removing the signal, and optionally applying a protease treatment to access the sample's DNA targets by subjecting the sample to an in situ hybridization reaction using a labeled nucleic acid probe, observing a signal from the labeled DNA targets, and optionally removing the signal. | 2014-01-23 |
20140024025 | UV ASSOCIATED MTDNA FUSION TRANSCRIPTS AND METHODS AND USES THEREOF - The present invention provides novel mitochondrial fusion transcripts and related deletion molecules that are associated with UV exposure. Methods for in vivo and in vitro detection of mtDNA molecules and associated fusion transcripts is also provided, as is their use in the screening and testing of skin care products. | 2014-01-23 |
20140024026 | METALLIC NANOPARTICLE SYNTHESIS WITH CARBOHYDRATE CAPPING AGENT - The disclosure relates to metal nanoparticle compositions and their methods of formation and use, in particular gold nanoparticles (AuNP) and gold-coated magnetic nanoparticles. Compositions according to the disclosure include aqueous suspensions of metal nanoparticles that are stabilized with one or more carbohydrate capping agents and/or that are functionalized with one or more binding pair members for capture/detection of a target analyte. The nanoparticle suspensions are stable for extended periods and can be functionalized as desired at a later point in time, typically prior to use in an assay for the detection of a target biological analyte. The stable nanoparticle suspension can be formed by the aqueous reduction of oxidized metal precursors at non-acidic pH values in the presence of a carbohydrate-based capping agent such as dextrin or other oligosaccharides. | 2014-01-23 |
20140024027 | Methods of enriching for and identifying polymorphisms - The invention encompasses methods for enriching for and identifying a polymorphism within a nucleic acid sample either by separating a subset of a nucleic acid sample or by selectively replicating a subset of a nucleic acid sample such that the polymorphism is contained within a nucleic acid population with reduced complexity, and then identifying the polymorphism within the enriched nucleic acid sample. Methods also are disclosed for enriching for and identifying a polymorphism by contacting a nucleic acid sample that includes a subset of nucleic acid molecules having a sequence that binds to a sequence-specific binding activity with a molecule having a sequence-specific binding activity under conditions which permit specific binding, such that the subset of nucleic acid molecules bound to the activity is enriched for nucleic acid molecules having the sequence recognized by the sequence-specific binding activity, and detecting a polymorphism with respect to a reference sequence in the subset of nucleic acid molecules. | 2014-01-23 |
20140024028 | BRCA DEFICIENCY AND METHODS OF USE - The invention generally relates to a molecular classification of disease and particularly to methods and compositions for determining BRCA deficiency. | 2014-01-23 |
20140024029 | METHODS FOR SELECTING MEDICATIONS FOR TREATING PATIENTS HAVING ATTENTION-DEFICIT HYPERACTIVITY DISORDER - Methods for selecting a medication for a patient are described that include determining the patient's genotype for a panel of genes, identifying a phenotype associated with the genotype for each gene, and selecting the medication based on the phenotype. | 2014-01-23 |
20140024030 | PRESELECTION OF SUBJECTS FOR THERAPEUTIC TREATMENT WITH OXYGEN SENSITIVE AGENTS BASED IN HYPOXIC STATUS - The present invention provides methods for the preselection of a subject for therapeutic treatment with an agent based on modulated levels of hypoxia in cancerous cells in the subject. In one embodiment, the invention provides methods for the preselection of a subject for therapeutic treatment with an agent based on modulated levels of lactate dehydrogenase (LDH) in a cell, e.g., a cancerous cell. The invention also provides methods for treating cancer in a subject by administering an effective amount of an agent to the subject, wherein the subject has been selected based on a modulated level of hypoxia. The invention further provides kits to practice the methods of the invention. | 2014-01-23 |
20140024031 | Method For Determining DNA Fragmentation In Microorganisms - The present invention relates to a process for determining the DNA integrity in microorganisms and a kit for evaluating the DNA integrity therein. Due to the fact that cell death means DNA fragmentation, with the present process the DNA fragmentation levels in microorganisms can be clearly discriminated in a simple, quick and accurate manner. | 2014-01-23 |
20140024032 | Method for Detecting Chromosome Structure and Gene Expression Simultaneously in Single Cells - The present invention relates to systems and methods for measuring chromosome structure and gene expression. In one embodiment, the present invention includes an assay for determining the spatial organization of gene expression in the nucleus. The present invention also includes a method based on fluorescence in situ hybridization (FISH) that simultaneously yields information on the physical position and expression of individual genes. By lighting up a large number of targets on a particular chromosome using a bar-coding scheme, the large scale structure of an entire chromosome can be determined. | 2014-01-23 |
20140024033 | DETECTING NUCLEIC ACID VARIATIONS WITHIN POPULATIONS OF GENOMES - This disclosure relates to amplification and detection of a rare variant or variants of a DNA sequence in an abundant variant of the sequence, such as detection of a low-level somatic mutations and minority alleles in an excess of normal nucleic acid target sequences. | 2014-01-23 |
20140024034 | NOVEL PRIMERS FOR DETECTING HUMAN CHROMOSOME END-TO-END TELEMORE FUSION - The present disclosure is directed to compositions and methods for detecting signs of telomere dysfunction as diagnostic indicators of metastatic disease. More particularly, diagnostic reagents and procedures are provided for analyzing samples to detect the presence of telomere fusions as an early diagnostic test for cancerous or pre-cancerous cells. | 2014-01-23 |
20140024035 | COMPREHENSIVE FMR1 GENOTYPING - Disclosed herein are methods for the automated reconstruction of a genotype of a gene, fragment, or genomic region using exhaustive enumeration. The methods can be used to reconstruct the genotype of any GC-rich sequence, such as the CGG repeat region in the 5′ UTR of FMR1 or the CCG repeat region in the 5′ UTR of FMR2. Also disclosed is an apparatus for use in conducting automated genotype reconstruction, as well as methods of diagnosis and treatment using exhaustive enumeration methods to reconstruct and identify genotypes associated with a disease or disorder. | 2014-01-23 |
20140024036 | METHODS AND MATERIALS FOR QUANTIFICATION OF FUSOBACTERIUM NUCLEATUM DNA IN STOOL TO DIAGNOSE COLORECTAL NEOPLASM - Methods and materials for detecting colorectal cancer using DNA markers from human stool. More specifically, methods and materials for quantification of FNN bacteria DNA per unit stool weight as a molecular marker for CRC diagnosis. | 2014-01-23 |
20140024037 | Endpoint Zygosity Assay To Detect RF4 Gene In Maize - A method is provided for determining the zygosity of an Rf4 gene in a corn plant. A method may include performing a first PCR assay, a second PCR assay, quantifying probes used in the first and second PCR assays, and comparing the quantified probes to determine zygosity. | 2014-01-23 |
20140024038 | METHOD AND REAGENTS FOR TREATING HEPATIC FIBROSIS AND INFLAMMATION - The invention relates to methods for identifying an anti-fibrotic or anti-inflammatory agent comprising determining cathepsin S expression in activated hepatic stellate cells which have been exposed to a test compound and comparing expression to non-exposed hepatic stellate cells. The invention also relates to methods for treating a disorder characterised or caused by hepatic fibrosis or inflammation, comprising administering a cathepsin S inhibitor to a subject. | 2014-01-23 |
20140024039 | METHODS FOR QUANTIFYING MICRORNA PRECURSORS - The present invention is directed to methods, reagents, kits and compositions for identifying and quantifying microRNA (miRNA) precursor expression in a biological sample. The method uses gene-specific primers and reverse transcriptase to convert the primary miRNA precursors (pri-miRNA) and pre-miRNA precursors (pre-miRNAs) to cDNA. The method also uses amplification reactions using gene specific forward and reverse primers that are targeted to the hairpin sequence of pri- and pre-microRNA precursors to detect the expression levels of both the pri- and the pre-micoRNAs. In one embodiment, the amplification reaction is a real-time PCR wherein the level of PCR amplification products produced is related to the levels of the microRNA precursors in the biological sample. In another embodiment, a probe is used to distinguish between similar isoforms of microRNA precursors. In another embodiment, the expression levels of a pre-miRNA precursor is calculated by using primers and amplification reactions that detect the pri-miRNA together with amplification reactions and primers that detect both pri- and pre-miRNAs, and calculating the difference. | 2014-01-23 |
20140024040 | METHODS AND KITS FOR BREAKING EMULSIONS - The disclosure relates generally to methods, systems, compositions and kits for breaking a water-in-oil emulsion including one or more biomolecules dispersed in an aqueous phase of the water-in-oil emulsion. In some embodiments, the disclosure relates to obtaining a first emulsion including a continuous hydrophobic fraction and a discontinuous aqueous fraction, the aqueous fraction having one or more biomolecules dispersed therein, breaking the first emulsion by contacting the first emulsion with a breaking solution including a second emulsion, where the second emulsion includes a discontinuous phase of organic extraction solvent dispersed in a continuous aqueous phase, and centrifuging to separate the phases of the resulting mixture. In some embodiments, the disclosure relates generally to methods, kits and systems for extracting biomolecules from a water-in-oil emulsion, including breaking a water-in-oil emulsion comprising a plurality of aqueous droplets in a continuous hydrophobic fraction using a breaking solution to produce a resulting reaction mixture containing one or more biomolecules and manipulating the resulting reaction mixture to form at least two phases, where one of the phases includes an aqueous phase containing the one or more biomolecules. | 2014-01-23 |
20140024041 | SOFT SUBSTRATE FOR CELL CULTURE AND PROCESS FOR PREPARING THE SAME - The present invention relates to a method for producing a soft substrate and to the soft substrate produced thereby, said substrate being particularly useful for cell culture. | 2014-01-23 |
20140024042 | BIOMARKERS FOR DETECTION AND DIAGNOSIS OF HEAD AND NECK SQUAMOUS CELL CARCINOMA - Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid, hyaluronidase and CD44 to diagnose HNSCC are described. | 2014-01-23 |
20140024043 | Mammalian Sweet and Amino Acid Heterodimeric Taste Receptors Comprising T1R3 and T1R1 - The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors. | 2014-01-23 |
20140024044 | CELL CYCLE MEASURING METHOD BASED ON AN ELECTROCHEMICAL METHOD - A method for measuring cell cycles includes immobilizing a capture specifically binding to a cell membrane protein to a substrate, wherein the cell membrane protein is a counterpartner binding to the capture, binding a cell having the cell membrane protein as the counterpartner to the capture, and measuring a redox potential of the cell. A method for screening a substance affecting cell cycles includes immobilizing a capture specifically binding to a cell membrane protein to a substrate; wherein the cell membrane protein is a counterpartner binding to the capture, binding a cell having the cell membrane protein as the counterpartner to the capture, treating a test substance of interest for analysis to a cell, and measuring a redox potential of the cell. | 2014-01-23 |
20140024045 | USE OF MICROPATTERNED SOFT SUBSTRATE FOR MEASURING OF CELL TRACTION FORCES - The present invention relates to devices and methods for the measurement of cell traction forces. In particular, the invention is based on the use of a soft substrate with cell adhesive micropatterns. | 2014-01-23 |
20140024046 | Exosomal Biomarkers for Cardiovasular Events - The present invention relates to a method of predicting the risk of a subject developing a cardiovascular event, comprising determining the presence of a biomarker that is indicative of the risk of developing a cardiovascular event in an exosome sample from the subject. The exosomes are suitably isolated from a body fluid selected from serum, plasma, blood, urine, amniotic fluid, malignant ascites, bronchoalveolar lavage fluid, synovial fluid, breast milk, saliva, in particular serum. Alternatively, the exosomes are present in a body fluid, in particular serum. The biomarker is selected from the proteins Vitronectin, Serpin F2, CD14, Cystatin C, Plasminogen, Nidogen 2, Serpin G1 or any combination of two or more of these proteins. The invention further relates to a method of diagnosing the occurrence of acute coronary syndrome in a subject, comprising determining the presence of a biomarker that is indicative of the occurrence of acute coronary syndrome in an exosome sample from the subject. In this method the biomarker is selected from Serpin F2, CD14, Cystatin C or combinations thereof. | 2014-01-23 |
20140024047 | COATED QUANTUM DOTS AND METHODS OF MAKING AND USING THEREOF - The present disclosure provides embodiments of a new class of hydroxylated quantum dots. The quantum dots have a hydroxylated coat disposed thereon, and which serves to minimize non-specific cellular binding and to maintain the small size of quantum dot probes. Embodiments of the coated quantum dots of the disclosure are just slightly larger than the diameter of uncoated quantum dots, and are bright with high quantum yields. They are also very stable under both basic and acidic conditions. Embodiments of the hydroxylated quantum dots result in significant reductions in non-specific binding relative to that of carboxylated dots, and to protein and PEG-coated dots. Embodiments of the disclosure are advantageous in a range of biological applications where non-specific binding is a major problem, such as in multiplexed biomarker staining in cells and tissues, detection of biomarkers in body fluid samples (blood, urine, etc.), as well as live cell imaging. | 2014-01-23 |
20140024048 | PROTEIN - The present invention provides methods and compositions for the treatment of and for screening, diagnosis and prognosis of colorectal cancer, for monitoring the effectiveness of colorectal cancer treatment, and for drug development. | 2014-01-23 |
20140024049 | Micro-Fluidic System Using Micro-Apertures for High Throughput Detection of Cells - A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target cells bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target cells from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target cells bound to magnetic beads on the surface of the plate. The microfluidic detection system includes a pump flowing the fluid through the detector component at high flow rates of milliliters per minute for high throughput detection of target cells. | 2014-01-23 |