| 01st week of 2011 patent applcation highlights part 34 |
| Patent application number | Title | Published |
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| 20110003301 | METHODS FOR DETECTING GENETIC VARIATIONS IN DNA SAMPLES - The invention provides methods, compositions and kits for detecting genetic variation in a DNA sample at one or more polymorphic loci of interest. In some embodiments, the invention provides methods, compositions, and kits for determining the nucleotide present at a single nucleotide variant position of interest in a test sample. | 2011-01-06 |
| 20110003302 | Fibroblast Growth Factor-Like Polypeptides - The present invention provides novel Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing FGF-like polypeptides. Also provided for are methods for the diagnosis and treatment of diseases associated with FGF-like polypeptides. | 2011-01-06 |
| 20110003303 | SHEATH FLOW DEVICES AND METHODS - The invention relates generally to fluid processing and, in particular aspects, processing fluids for detection, selection, trapping and/or sorting of particulate moieties. Sheath flow devices described allow isolation of target species from fluid samples while avoiding non-specific binding of unwanted species to the surfaces of the separation device. Biological fluid processing, detection, sorting or selection of cells, proteins, and nucleic acids is described. The invention finds particular use in diagnostic settings, analyzing a patient's medical condition, monitoring and/or adjusting a therapeutic regimen and producing cell based products. | 2011-01-06 |
| 20110003304 | METHOD AND KIT FOR DETECTION OF AUTOIMMUNE CHRONIC URTICARIA - Disclosed is a rapid, non-invasive and highly specific and sensitive diagnostic assay for the identification of individuals with autoimmune chronic urticaria, which makes use of CD203c, and in some embodiments, additional proteins, as a marker for the disease. Test kits for diagnosis of an individual suspected of having autoimmune chronic urticaria are also disclosed. Also disclosed are a method of identifying compounds useful for treating autoimmune chronic urticaria and a method of treating autoimmune chronic urticaria. | 2011-01-06 |
| 20110003305 | METHODS AND COMPOSITIONS FOR NUCLEIC ACID AMPLIFICATION - Compositions, reaction mixtures, and methods for performing an amplification reaction, including multiplex amplification reaction, wherein the method comprises using one or more amplification oligomer complexes comprising linked first and second amplification oligomer members. In one aspect, the amplification oligomer complex is hybridized to a target nucleic acid, the target nucleic acid with hybridized amplification oligomer complex is then captured, and other components are washed away. Target sequences of the target nucleic acids are pre-amplified to generate a first amplification product. The first amplification product is amplified in one or more secondary amplification reactions to generate second amplification products. | 2011-01-06 |
| 20110003306 | IDENTIFICATION OF ANTIBIOTIC RESISTANCE USING LABELLED ANTIBIOTICS - Subject of the present invention is a method for detection of an antibiotic resistance in a micro-organism comprising the steps of exposing suspected micro-organism to a labelled (fluorescent) antibiotic and observing the differences between it and a non-resistant micro-organism of the same type. | 2011-01-06 |
| 20110003307 | METHODS FOR PRODUCING INTERFERING RNA MOLECULES IN MAMMALIAN CELLS AND THERAPEUTIC USES FOR SUCH MOLECULES - Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided. | 2011-01-06 |
| 20110003308 | NANOPARTICLE-MEDIATED SIGNAL AMPLIFICATION - There is described a new class or type of initiators for polymerization as a means of signal enhancement, nanoparticle initiators, and methods for amplifying signal resulting from recognition events, thereby enhancing the detection of those recognition events. Methods include amplification achieved through polymerization using a nanoparticle initiator conjugated recognition element that is not consumed during the reaction. The polymer formed as a result of the absorption of light by the nanoparticle initiator and introduction of reactive species into a surrounding polymerizable monomer solution occurs in a spatially-limited region directly surrounding the nanoparticle initiator and is indicative of the recognition event(s). In one embodiment, a semiconductor quantum dot nanoparticle initiator is utilized. In another embodiment, a metal nanoparticle is utilized. In another embodiment, the signal is detected without instrumentation. In yet another embodiment, the signal is detected via a transmission-based instrument which captures an image of the formed polymer. | 2011-01-06 |
| 20110003309 | Non-Competitive Internal Controls for Use in Nucleic Acid Tests - Provided are non-competitive internal controls for use in nucleic acid tests (NATs), which are obtained from the organisms | 2011-01-06 |
| 20110003310 | ORAL FLUID RAPID IMMUNOCHROMATOGRAPHY TEST - The present invention relates to an oral fluid rapid immunochromatography test. More particularly, the present invention relates to an oral fluid collection swab separate from a lateral flow immunochromatography strip for detecting an analyte in oral fluid, consisting essentially of a sample pad, a conjugate pad, a test zone and control zone pad made of at least one matrix material, wherein the conjugate pad lies downstream of the sample pad, and is striped with a conjugate; the test and control zone pad lies downstream of the conjugate pad, wherein the test zone is immobilized with an specific binding reagent that specifically binding to the target analyte; and the control zone, downstream of the test zone, is immobilized with a second capture reagent. The invention also relates to a method for manufacturing the strip, a lateral flow immunochromatography method for detecting an analyte in oral fluid by using the strip, and kits containing the strip. | 2011-01-06 |
| 20110003311 | DIAGNOSIS SYSTEM FOR DETERMINING THE BIOLOGICALLY EFFECTIVE PARATHYROID HORMONE ACTIVITY IN A SAMPLE - Diagnosis system or immunoassay for the determination of the effective parathyroid hormone activity in a sample, and for a diagnosis and treatment of calcium metabolism disturbances, osteopathies and hyper- or hypoparathyroidisms. The parathyroid hormone activity is measured with the aid of an antibody which binds to an epitope in the region of the receptor binding structure | 2011-01-06 |
| 20110003312 | LINKED PEPTIDE FLUOROGENIC BIOSENSORS - Biosensors, compositions comprising biosensors, methods of producing biosensors, and methods of using biosensors are disclosed. The biosensors comprise a fluorogen-activating peptide and a blocking peptide. The fluorogen-activating peptide and blocking peptide are covalently linked through a peptide linker. The blocking peptide associates with the fluorogen-activating peptide thereby blocking an active domain of the fluorogen-activating peptide when the linker is in an unmodified state. The peptide linker may contain an amino acid sequence that is specifically recognized as a modification substrate by a cognate enzyme. The fluorogen-activating peptide and the blocking peptide at least partially disassociate when the linker is modified by an enzyme, thereby allowing the fluorogen-activating peptide to bind a cognate fluorogen and modulate a fluorescence signal. | 2011-01-06 |
| 20110003313 | AMPLIFIED LABELED CONJUGATE FOR USE IN IMMUNOASSAYS - A conjugate, for use as a detection reagent in an immunoassay, is based on a hydrophilic monodisperse macromolecule, i.e. a macromolecule having a substantially uniform size and shape, the macromolecule forming a practically useful and manageable carrier, to which carrier at least one binding entity and at least one label are bound. | 2011-01-06 |
| 20110003314 | Hapten, Immunogens and Derivatives of Ascomycin Useful for Preparation of Antibodies and Immunoassays - The invention teaches derivatives of ascomycin and methods of preparing immunogens and other conjugates useful in immunoassays for quantitatively measuring concentrations of tacrolimus in patient specimens. Antibodies produced from the disclosed immunogens capable of binding to tacrolimus with cross-reactivity of no more than 5% with each of 15-O-demethyl tacrolimus, 31-O-demethyl tacrolimus, and 13,31-O-didemethyl tacrolimus, less than 40% with 13-O-demethyl tacrolimus, and less than 1% with cyclosporin, rapamycin, mycophenolic acid, prednisone, hydrocortisol, and prednisolone are described. Further, immunoassays for measuring the concentration of tacrolimus using such antibodies are taught. | 2011-01-06 |
| 20110003315 | CHIMERIC PCSK9 PROTEINS, CELLS COMPRISING SAME, AND ASSAYS USING SAME - A chimera protein comprising in the following order: a signal peptide, a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) sequence consisting of amino acid residues at positions 35 to 696 of SEQ ID NO: 38, a transmembrane domain and a cytosolic domain, wherein said cytosolic (CT) domain comprises a sequence able to recycle the protein from the cellular membrane to endosomes. | 2011-01-06 |
| 20110003316 | LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY - The present invention provides methods, compositions, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their effect on cytochrome P450 activity. In particular, a one-step and two-step methods using luminogenic molecules, e.g. luciferin or coelenterazines, that are cytochrome P450 substrates and that are also bioluminescent enzyme, e.g., luciferase, pro-substrates are provided. Upon addition of the luciferin derivative or other luminogenic molecule into a P450 reaction, the P450 enzyme metabolizes the molecule into a bioluminescent enzyme substrate, e.g., luciferin and/or luciferin derivative metabolite, in a P450 reaction. The resulting metabolite(s) serves as a substrate of the bioluminescent enzyme, e.g., luciferase, in a second light-generating reaction. Luminescent cytochrome P450 assays with low background signals and high sensitivity are disclosed and isoform selectivity is demonstrated. The present invention also provides an improved method for performing luciferase reactions which employs added pyrophosphatase to remove inorganic pyrophosphate, a luciferase inhibitor which may be present in the reaction mixture as a contaminant or may be generated during the reaction. The present method further provides a method for stabilizing and prolonging the luminescent signal in a luciferase-based assay using luciferase stabilizing agents such as reversible luciferase inhibitors. | 2011-01-06 |
| 20110003317 | METHODS OF SCREENING COMPOUNDS FOR INSECT-CONTROL ACTIVITY INVOLVING THE TYRAMINE RECEPTOR - An exemplary method of screening compositions for insect control activity includes, providing an insect cell expressing a receptor of the insect olfactory cascade or fragment thereof, contacting a test composition to the insect cell, measuring at least one parameter selected from olfactory cascade receptor binding affinity, intracellular cAMP levels, and intracellular Ca | 2011-01-06 |
| 20110003318 | NUCLEOTIDE AND PROTEIN SEQUENCE OF MAMMASTATIN AND METHODS OF USE - A nucleic acid sequence encoding Mammastatin, a specific mammary cell growth inhibitor. Mammastatin is encoded by a single nucleic acid sequence and has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and 49 kDa. Metastatic mammary cells either do not express Mammastatin at all, or do not express the 53 kDa or 49 kDa, phosphorylated forms. Mammary cancer cells are inhibited in their growth by the administration of phosphorylated mammastatin. | 2011-01-06 |
| 20110003319 | Transgenic Trasnchromosomal Rodents for Making Human Antibodies - The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies. | 2011-01-06 |
| 20110003320 | IMMUNOASSAY METHOD AND KIT AND DEVELOPING SOLVENT THEREFOR - An immunoassay method and a kit which comprises a combination of a test piece for immunochromatography and a developing solvent, by which a target substance is detected accurately in a short period of time while a preventing a nonspecific reaction. | 2011-01-06 |
| 20110003321 | Monitoring of Intercellular Mitochondorial Polarization - An object is a method of detecting changes in mitochondrial polarized state in a living cell. | 2011-01-06 |
| 20110003322 | CELL-ENZYME BASED BIOSENSORS - The invention relates to a sensor ( | 2011-01-06 |
| 20110003323 | Bioreactor systems and associated methods of processing bioreactor vessels - A bioreactor processing unit ( | 2011-01-06 |
| 20110003324 | MICROFLUIDIC DEVICE HAVING ONBOARD TISSUE OR CELL SAMPLE HANDLING CAPABILITY - The present disclosure is generally directed to systems for the storage and preservation of an original tissue or cell sample onboard a microfluidic device, such as a cytometry chip. In some embodiments, the sample may be disassociated while onboard the microfluidic device. | 2011-01-06 |
| 20110003325 | MICROFLUIDIC DEVICE - The present disclosure relates to microfluidic devices adapted for facilitating cytometry analysis of particles flowing therethrough. In certain embodiments, the microfluidic devices have onboard sterilization capabilities. In other embodiments, microfluidic devices have integral collection bags and methods for keeping the microfluidic channels clean. | 2011-01-06 |
| 20110003326 | MICROINJECTION APPARATUS AND METHOD - The present invention discloses a microinjection apparatus ( | 2011-01-06 |
| 20110003327 | METHODS FOR PRODUCTION OF ATRIAL PROGENITORS AND THEIR DIFFERENTIATION INTO SMOOTH MUSCLE CELLS AND CARDIOMYOCYTES - The present invention generally relates to methods to identify and isolate atrial progenitors, and in some embodiments to the atrial progenitors are positive for both Islet 1 (Isl1) and sarcolipin (SLN). One aspect of the present invention relates to methods to differentiate progenitors into Isl1+/SLN+ atrial progenitors. Another aspect of the invention relates to methods to differentiate Isl1 | 2011-01-06 |
| 20110003328 | SYSTEM FOR DETECTING MICROBIAL CONTAMINATION - The present invention relates to a system for detecting microbial contamination of a liquid specimen comprising a device for concentrating micro-organisms from a liquid specimen, having (i) a hypobaric chamber, (ii) a filter housing comprising a liquid-permeable bed of an adsorbent material and adapted for being fluidly connected to said hypobaric chamber, and (iii) a vacuum pump adapted for being fluidly connected to said hypobaric chamber, said system further comprising a kit for detection of micro-organisms adsorbed to said adsorbent material, wherein said kit is based on enzymatic detection using chromogenic and/or fluorescent substrate analogues. | 2011-01-06 |
| 20110003329 | METHOD FOR NEUTRALIZATION OF ANTIBIOTICS IN A CULTURE MEDIUM - The present invention is directed to a method and means for the neutralization, binding, and/or inactivation of antimicrobials in a test sample. The invention is also directed to a method of detecting the presence of one or more microorganisms in a test sample by culturing the test sample in a culture media comprising one or more primary amine-containing compounds. | 2011-01-06 |
| 20110003330 | MICROFLUIDIC DEVICE - The present disclosure relates to microfluidic devices adapted for facilitating cytometry analysis of particles flowing therethrough. In certain embodiments, the microfluidic devices have onboard data storage capabilities. In certain other embodiments, the microfluidic devices have onboard anticoagulants. In certain other embodiments, the microfluidic devices have onboard test and control channels. In certain other embodiments, the microfluidic devices have integrated collection media. In certain other embodiments, the microfluidic devices have multiple onboard test channels. In certain other embodiments, the microfluidic devices have localized temperature control. In certain other embodiments, the microfluidic devices have anatomy simulating regions. In certain other embodiments, the microfluidic devices have complete assay capabilities. In certain other embodiments, the microfluidic devices have dissociable sections. In certain other embodiments, the microfluidic devices have means for performing functional assays. | 2011-01-06 |
| 20110003331 | Method for enhanced production of biofuels and other chemicals using biological organisms - The invention of this disclosure, also known as the method of this disclosure, provides the means of improved Chemical Product production from chemical production systems that use biological organisms to produce the desired chemicals. This improved production is by means of subjecting chemical producing organisms to vibration waves or to an electrical voltage potential. The waves or voltage accomplish one of two things or both: they will improve the extraction of the chemicals from the bodies and cells of organisms, or they will increase the rate at which the organisms synthesize chemicals. To illustrate how one of many possible chemical production systems can incorporate this method, a specific configuration for a continuous chemical production system called the Oil Production System | 2011-01-06 |
| 20110003332 | RECOMBINANTLY MODIFIED PLASMIN - Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, combined such that no foreign sequences are present, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme. | 2011-01-06 |
| 20110003333 | Method for Increasing Expression Yield of a Protein of Interest - The present invention relates to a method of producing a protein of interest comprising: (a) cultivating a mutant cell under conditions conducive for production of the protein wherein the mutant has a reduced or no expression of an endogenous polypeptide shown in SEQ ID NO: 2 compared to a parent host cell grown under the same conditions; and optionally (b) recovering the protein of interest. | 2011-01-06 |
| 20110003334 | METHOD FOR PRODUCING A CELL CAPABLE OF HIGH-YIELD PRODUCTION OF HETEROPROTEINS - The present invention provides a cell capable of high-yield production of polypeptides and a method for producing the same. | 2011-01-06 |
| 20110003335 | METHODS FOR PROGNOSING THE STATUS OF TUMOR PATIENTS - A method for prognosing the status of a tumor patient is provided, wherein the level of antibodies against | 2011-01-06 |
| 20110003336 | Methods for Increasing the Therapeutic Efficacy of Immunoglobulin G Class 3 (IgG3) Antibodies - The present invention relates to methods for increasing the therapeutic efficacy of immunoglobulin G class 3 (IgG3) antibodies, immunoglobulin G class 3 (IgG3) antibodies with an improved therapeutic efficacy and the use thereof as a medicament, in particularly a medicament for immunotherapy. Specifically, the present invention relates to methods for increasing the therapeutic efficacy of an immunoglobulin G class 3 (IgG3) antibody comprising providing a mutated immunoglobulin G class 3 (IgG3) antibody, wherein the mutation, as compared to the parent immunoglobulin G class 3 (IgG3) antibody, comprises a replacement of the amino acid arginine (R) at position 435 in the C | 2011-01-06 |
| 20110003337 | IMMUNOGLOBULIN COMPOSITIONS AND METHODS OF PRODUCING SAME - 1. A method of producing an immunoglobulin in a bacterial culture, the method comprising: | 2011-01-06 |
| 20110003338 | ANTIBODIES WITH ENHANCED ADCC FUNCTION - The present invention concerns antibodies enhanced antibody-dependent cell mediated cytotoxicity (ADCC) and method for preparation thereof. | 2011-01-06 |
| 20110003339 | Pathogenic Escherichia Coli Associated Protein - The present invention provides a polypeptide, called EspA, which is secreted by pathogenic | 2011-01-06 |
| 20110003340 | SYNTHETIC GENES FOR PLANT GUMS AND OTHER HYDROXYPROLINE-RICH PROTEINS - A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline (Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabinogalactan-proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAGP), is taught in host cells, including plant host cells. | 2011-01-06 |
| 20110003341 | PROCESS FOR PRODUCING SACCHARIDE - A process for producing saccharide, including saccharifying decrystallized cellulose prepared from a raw material containing cellulose having cellulose I-type crystallinity of more than 33%, the process including: treating the cellulose-containing raw material by means of a mill to reduce the cellulose I-type crystallinity of the cellulose to 33% or less, wherein the cellulose-containing raw material has a cellulose content of a residue obtained by removing water from the cellulose-containing raw material of 20% by weight or more, to thereby prepare decrystallized cellulose, and causing a cellulase and/or a hemicellulase to act on the decrystallized cellulose. | 2011-01-06 |
| 20110003342 | INOSINE PRODUCING MICROORGANISM BELONGING TO THE GENUS CORYNEBACTERIUM AND PROCESS OF PRODUCING INOSINE USING THE SAME - A microorganism of the genus | 2011-01-06 |
| 20110003343 | CONJUGATES OF BIOMOLECULES TO NANOPARTICLES - Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity. Such conjugates can exhibit reduced aggregation and improved stochiometries wherein the average biomolecule:nanoparticle ratio approaches or equals 1:1. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing. | 2011-01-06 |
| 20110003344 | METHODS AND ORGANISMS FOR UTILIZING SYNTHESIS GAS OR OTHER GASEOUS CARBON SOURCES AND METHANOL - The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO | 2011-01-06 |
| 20110003345 | Production and Secretion of Glucose in Photosynthetic Prokaryotes (Cyanobacteria) - The present invention includes compositions and methods for making and using an isolated cyanobacterium that includes a portion of an exogenous bacterial cellulose operon sufficient to express bacterial cellulose, whereby the cyanobacterium produces extracellular glucose. The compositions and methods of the present invention may be used as a new global crop for the manufacture of cellulose, CO | 2011-01-06 |
| 20110003346 | SYNTHESIS METHOD OF AROMATIC AMINO ACIDS - A synthesis method of aromatic amino acids according to one aspect of the present invention includes a process of preparing thermostable enzyme, a process of amino-transferring reaction and a process of product precipitation and enzyme recycling. The process of preparing thermostable enzyme comprises an isolation step of the gene of | 2011-01-06 |
| 20110003347 | METHOD FOR PRODUCING A TARGET SUBSTANCE BY FERMENTATION - A method is described for producing a target substance utilizing a microorganism by culturing the microorganism in a medium to produce and accumulate the target substance in the medium, and then collecting the target substance from culture. The microorganism is imparted with isomaltase activity, or modified to increase isomaltase activity. | 2011-01-06 |
| 20110003348 | ORGANIC MATERIAL PRODUCTION SYSTEM USING BIOMASS MATERIAL AND METHOD - An organic material production system includes: a pretreatment device ( | 2011-01-06 |
| 20110003349 | L-Threonine Overproducing Microorganism and Method for Preparing L-Threonine Using the Same - The present invention relates to a mutant microorganism producing a high concentration of L-threonine in high yield, prepared using site-specific mutation, not random mutation, such as treatment with a mutation inducer, a method for preparing the same, and a method for preparing L-threonine using the mutant microorganism producing L-threonine. By using the mutant microorganism according to the present invention, L-threonine can be prepared at high yield, additional strain development becomes possible and their physiological phenomena can be easily understood since genetic information of L-threonine producing microorganism can be identified. | 2011-01-06 |
| 20110003350 | SYSTEM AND METHOD FOR HIGH-VOLTAGE PULSE ASSISTED AGGREGATION OF ALGAE - A method and device for aggregating algae in an aqueous solution is disclosed. The method can include providing an algae feed comprising a liquid and algae dispersed therein. The algae feed can be aggregated by applying a nanosecond pulsed electric field to the algae feed. The nanosecond pulsed electric field can include a plurality of electric pulses having a pulse duration ranging from 1 to 1,000 nanoseconds. The method can also include separating an aggregated algae stream from the algae feed and feeding the aggregated algae stream to a lipid extraction operation. | 2011-01-06 |
| 20110003351 | DELTA-5 DESATURASE AND USES THEREOF - The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “Δ5-desaturase”) and at carbon 6 (i.e., “Δ6-desaturase”) and to uses thereof. In particular, Δ5-desaturase may be utilized, for example, in the conversion of dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to γ-linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics. | 2011-01-06 |
| 20110003352 | PROCESS FOR THE STEPWISE TREATMENT OF LIGNOCELLULOSIC MATERIAL TO PRODUCE REACTIVE CHEMICAL FEEDSTOCKS - A method for the fractionation of lignocellulosic materials into reactive chemical feedstock in a batch or semi continuous process by the stepwise treatment with aqueous aliphatic alcohols in the presence of sulfur dioxide or acid. Lignocellulosic material is fractionated in a fashion that cellulose is removed as pulp, or converted to esterified cellulose, cooking chemicals are reused, lignin is separated in the forms of reactive native lignin and reactive lignosulfonates and hemicelluloses are converted into fermentable sugars, while fermentation inhibitors are removed. In an integrated vapor compression stripper and evaporator system, aliphatic alcohol is removed from a liquid stream and the resulting stream is concentrated for further processing. | 2011-01-06 |
| 20110003353 | Multimeric Oxidoreductases - The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof. | 2011-01-06 |
| 20110003354 | METHOD FOR CONVERTING HERBACEOUS PLANT FIBERS INTO FUEL ALCOHOL - This disclosure teaches a method of converting herbaceous plant fibers into fuel alcohol comprising the following steps: The pre-treatment stage consists of grinding; using ultrasonic waves; adding the liquids mixed with alcohol, liquid ammonia, and water; adding NaOH; and then stirring and cooking. The second stage involves the recovery of organic liquids as well as high-pressure and high-temperature washing. Next, biological enzyme hydrolysis is conducted by adding endo-β-glucanase, exo-β-glucanase, and β-glucanase. | 2011-01-06 |
| 20110003355 | PROCESS OF SEPARATING COMPONENTS OF A FERMENTATION BROTH - A process of isolating 1,4-butanediol (1,4-BDO) from a fermentation broth includes separating a liquid fraction enriched in 1,4-BDO from a solid fraction comprising cells, removing water from said liquid fraction, removing salts from said liquid fraction, and purifying 1,4-BDO. A process for producing 1,4-BDO includes culturing a 1,4-BDO-producing microorganism in a fermentor for a sufficient period of time to produce 1,4-BDO. The 1,4-BDO-producing microorganism includes a microorganism having a 1,4-BDO pathway having one or more exogenous genes encoding a 1,4-BDO pathway enzyme and/or one or more gene disruptions. The process for producing 1,4-BDO further includes isolating 1,4-BDO. | 2011-01-06 |
| 20110003356 | PROCESS FOR PRODUCTION OF XYLITOL - The invention provides a process for producing xylitol from xylose by a yeast strain capable of converting the xylose to xylitol comprising independently growing the yeast strain in a medium; transferring the yeast strain from the medium to a feed solution, the feed solution comprising of xylose in water, and separating the xylitol from said feed solution. | 2011-01-06 |
| 20110003357 | CONVERSION OF ALGAE TO LIQUID METHANE, AND ASSOCIATED SYSTEMS AND METHODS - Systems and methods for converting algae to liquid methane are disclosed. The system in accordance with a particular embodiment includes an algae cultivator, an anaerobic digester operatively coupled to the algae cultivator to receive algae and produce biogas, and a biogas converter coupled to the anaerobic digester to receive the biogas and produce liquefied methane and thermal energy, at least a portion of the thermal energy resulting from a methane liquefaction process. The system can further include a thermal path between the biogas converter and at least one of the algae cultivator and the anaerobic digester. The system can still further include a controller coupled to the biogas converter and at least one of the algae cultivator and the anaerobic digester. The controller can be programmed with instructions that, when executed (e.g., based on measured variables of the system), direct the portion of thermal energy between the biogas converter and the algae cultivator and/or anaerobic digester. | 2011-01-06 |
| 20110003358 | CULTURES OF GFAP+ NESTIN+ CELLS THAT DIFFERENTIATE TO NEURONS - Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. The cells can be proliferated in adherent or suspension cultures. Depending on the culture conditions, the cells can be induced to differentiate to neurons or glial cells. The cultures can be expanded over a large number of passages during several months, and survive, express an astroglial phenotype and integrate well after transplantation into both neonatal and adult rat forebrain. | 2011-01-06 |
| 20110003359 | BIODEVICE - Disclosed is a biodevice which has a porous membrane ( | 2011-01-06 |
| 20110003360 | DELTA-6 DESATURASE AND USES THEREOF - The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “Δ5-desaturase”) and at carbon 6 (i.e., “Δ6-desaturase”) and to uses thereof. In particular, Δ5-desaturase may be utilized, for example, in the conversion of dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to γ-linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics. | 2011-01-06 |
| 20110003361 | NOVEL FRUCTOSYL PEPTIDE OXIDASE - The present invention has an object of providing a novel fructosyl peptide oxidase having superior physicochemical properties such as stability that is useful as an enzyme for clinical diagnosis, and an object of providing a method for producing the fructosyl peptide oxidase. | 2011-01-06 |
| 20110003362 | Conjugates of biological substances - Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens. | 2011-01-06 |
| 20110003363 | Reduction of Dimer Content in Factor VII Polypeptide Compositions by Heat Treatment - The present application relates to a method of reducing the content of dimers in Factor VII polypeptide composition by heat treatment. | 2011-01-06 |
| 20110003364 | SUBTILASES - The present invention relates to methods for producing variants of a parent TY145 subtilase and of a parent BPN′ subtilase and to TY145 and BPN′ variants having altered properties as compared to the parent TY145/BPN′ subtilase. | 2011-01-06 |
| 20110003365 | METHOD OF PREPARING INDUCED PLURIPOTENT STEM CELLS DEPRIVED OF REPROGRAMMING GENE - Provided is a method of preparing an induced pluripotent stem cell (iPS cell) deprived of a reprogramming gene, including providing an iPS cell having an expression vector wherein a loxP sequence is placed on each of the 5′ and 3′ sides of the reprogramming gene or a vector component necessary for the replication of the reprogramming gene in the same orientation, and treating the IPS cell with Cre recombinase. Also provided are an iPS cell deprived of a reprogramming gene, as obtained by the method, and a use of the iPS cell as a cell source for producing somatic cells. | 2011-01-06 |
| 20110003366 | METHODS OF USING PNEUMATIC BIOREACTORS - A pneumatic bioreactor includes a vessel containing a fluid to be mixed and at least one mixing device driven by gas pressure. A first embodiment includes a floating impeller that rises and falls in the fluid as gas bubbles carry it upward to the surface where the gas is then vented, permitting the impeller to sink in the fluid. The floating impeller may be tethered to a second impeller with a flexible member and pulley. The mixing speed is controlled with electromagnets in the vessel acting upon magnetic material in the impeller or its guides. In another embodiment, floating pistons mix the fluid, pushing it through a mixing plate with one or more apertures. In a third embodiment, the mixing device is a rotating drum with bubble-catching blades and rotating mixing plates with apertures. The top of the vessel for these mixers may include a closed top and sterile filters. | 2011-01-06 |
| 20110003367 | Material For Capturing Microbes, Device For Capturing Microbes, Method Of Capturing Microbes, And Method Of Producing Material For Capturing Microbes - The invention relates to a material for capturing microbes or the like, a device for capturing microbes or the like, a method of capturing microbes or the like, and a method of producing a material for capturing microbes or the like, and has an object of using a pulverizable resin whereby a minor amount of microbes or the like contained in a large amount of a liquid, or microbes or the like contained in a small amount of a liquid can be captured efficiently, quickly, labor-savingly, and reliably. Disclosed is: a material for capturing microbes or the like, which comprises irregular-shaped powdery grains made of a pulverizable adsorbent resin and distributed in a predetermined grain size range, and which can adsorb or bond to a target such as a microbe contained in a liquid; a device for capturing microbes or the like; and a method of capturing microbes or the like. | 2011-01-06 |
| 20110003368 | Thixotropic gel for vadose zone remediation - A thixotropic gel suitable for use in subsurface bioremediation is provided along with a process of using the gel. The thixotropic gel provides a non-migrating injectable substrate that can provide below ground barrier properties. In addition, the gel components provide for a favorable environment in which certain contaminants are preferentially sequestered in the gel and subsequently remediated by either indigenous or introduced microorganisms. | 2011-01-06 |
| 20110003369 | METHOD FOR THE DEPARAFFINISATION OF BIOLOGICAL SPECIMENS - A method for isolating biomolecules from a fixed biological specimen embedded in paraffin, comprises the steps of bringing the specimen into contact
| 2011-01-06 |
| 20110003370 | PROCESS TO REMOVE IMPURITIES FROM TRIACYLGLYCEROL OIL - The present invention is directed to a process to remove impurities from triacylglycerol oil including mixing the oil and a fluidic agent, pumping the mixture through a flow-through hydrodynamic cavitation apparatus at a pre-determined inlet pump pressure, creating hydrodynamic cavitation in the mixture, maintaining the hydrodynamic cavitation for a pre-determined period of time, moving the impurities from the oil to the fluidic agent, and then separating the fluidic agent from the oil. The impurities can include phytosterols, sterol glucosides, acylated sterol glucosides, in which case the fluidic agent is water, an alkali hydroxide, an inorganic base, an organic base, phosphoric acid, citric acid, acetic acid or a mixture thereof. The impurities may also include phosphatides, in which case and the fluidic agent comprises water and an enzyme such as phospholipase, a lipid acyltransferase or a mixture thereof. | 2011-01-06 |
| 20110003371 | DIAGNOSTIC DEVICES - The present invention relates to analytical methods, platforms, and devices for the rapid and efficient immunochromatic determination of one or more components in fluid samples. The devices are especially useful for identifying analytes in small volumes of whole blood samples utilizing one membrane principally for separating particles such as red blood cells from plasma and a second membrane as the site for reactions to identify the analytes. | 2011-01-06 |
| 20110003372 | MICROFLUIDIC GRADIENT DEVICES - Provided herein are apparatuses, systems and methods for the efficient generation of gradients. | 2011-01-06 |
| 20110003373 | ANALYTE TREATMENT APPARATUS - The present invention provides an analyte treatment apparatus that makes it easy to check various information about liquid chemicals stored in liquid chemical tanks made of resin from outside the liquid chemical tanks. | 2011-01-06 |
| 20110003374 | BIOREACTOR - A bioreactor ( | 2011-01-06 |
| 20110003375 | FLOW REACTOR - A reaction system and a reactor which comprises of two or more reaction cells wherein said cells are separated by inter cell conduits and having a means of causing agitation within the cells which does not require a mechanical connection of the agitating mechanism within the cell to a drive mechanism which is outside the cell. | 2011-01-06 |
| 20110003376 | Cell Culture Dish - A cell culture dish, comprising: a dish with a bottom wall and a circumferential side wall standing upward from the same, a lid, which sits sealingly on the side wall in an aeration position, and means for holding the lid on the dish above the sealing position in an aeration position in which there is an aeration gap between side wall and lid, wherein these means are adapted to be overcome by pressing the lid and the dish together in order to bring the lid from the aeration position into the sealing position. | 2011-01-06 |
| 20110003377 | SPECIMEN PROCESSING APPARATUS AND SPECIMENT PROCESSING METHOD - According to an example of the invention, a specimen processing apparatus which distributes specimen containers capable of containing a specimen each to a plurality of outlet ports, includes, a plurality of inlet ports, the outlet ports disposed downstream relative to the inlet ports, a plurality of main transport paths which convey the specimen containers from the inlet ports to the outlet ports, a plurality of auxiliary transport paths which diverge from the main transport paths, connect the main transport paths to one another, and convey the specimen containers on the main transport paths to the alternative main transport paths, and a guide unit which guides the transport direction of the specimen containers between the main transport paths and the auxiliary transport paths. | 2011-01-06 |
| 20110003378 | MULTIPLE PROMOTER EXPRESSION CASSETTES FOR SIMULTANEOUS DELIVERY OF RNAi AGENTS - The present invention provides multiple-promoter expression cassettes for simultaneous delivery of RNAi, preferably to mammalian cells in vivo. | 2011-01-06 |
| 20110003379 | CHIMERIC AUTOPROCESSING POLYPEPTIDES AND USES THEREOF - A chimeric polypeptide comprising an autoprocessing segment having an amino acid sequence being capable of auto-cleavage, a polynucleotide encoding such a polypeptide, and uses of such a polypeptide and such a polynucleotide are provided. a polynucleotide are provided. | 2011-01-06 |
| 20110003380 | Sample Processing System and Methods - The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder ( | 2011-01-06 |
| 20110003381 | VIRAL VECTORS AND HOST CELLS AND METHODS OF MAKING AND USING THEM - The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating, selectively packaging, and using such a vector, isolated molecules of specified nucleotide and amino acid sequences relevant to such vectors, a pharmaceutical composition and a host cell comprising such a vector, and methods of using such a vector and a host cell. | 2011-01-06 |
| 20110003382 | USE OF CORTICOSTERONE FOR INCREASING EGG ANTIBODY - Methods for increasing antigen-specific egg yolk antibody titer and eggs having increased antigen-specific egg yolk antibody titer are disclosed. More specifically, the method for increasing antibody titer may include the steps of: administering to an egg-laying animal a corticosteroid; and then, exposing the animal to an immunogenic dose of the antigen. | 2011-01-06 |
| 20110003383 | ANTIBODIES TO HT5GJ57 - The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins. | 2011-01-06 |
| 20110003384 | COMPOSITIONS AND METHODS OF USE FOR MGD-CSF IN DISEASE TREATMENT - Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss. | 2011-01-06 |
| 20110003385 | REGULATED TRANSCRIPTION OF TARGETED GENES AND OTHER BIOLOGICAL EVENTS - Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins. In principle, any two target proteins can be induced to associate by treating the cells or organisms that harbor them with cell permeable, synthetic ligands. To illustrate the practice of this invention, we have induced: (1) the intracellular aggregation of the cytoplasmic tail of the ζ chain of the T cell receptor (TCR)-CD3 complex thereby leading to signaling and transcription of a reporter gene, (2) the homodimerization of the cytoplasmic tail of the Fas receptor thereby leading to cell-specific apoptosis (programmed cell death) and (3) the heterodimerization of a DNA-binding domain (Gal4) and a transcription-activation domain (VP16) thereby leading to direct transcription of a reporter gene. | 2011-01-06 |
| 20110003386 | IDENTIFICATION AND CHARACTERIZATION OF CANCER STEM CELLS AND METHODS OF USE - A subpopulation of cancer stem cells expressing elevated levels of uPAR have been identified among a population of cancer cells. Methods are provided for treating proliferative disorders such as cancer by administering one or more uPAR inhibitors. Methods are likewise provided for predicting the likelihood of recurrence of a cancer, preventing recurrence of a cancer, and identifying the likelihood of a cancer to respond to a particular cancer therapy. | 2011-01-06 |
| 20110003387 | METHOD OF PRODUCING ERYTHROCYTES WITHOUT FEEDER CELLS - Provided herein are methods of producing erythrocytes from hematopoietic cells, particularly hematopoietic cells from placental perfusate in combination with hematopoietic cells from umbilical cord blood, wherein the method results in accelerated expansion and differentiation of the hematopoietic cells to more efficiently produce administrable erythrocytes. Further provided herein is a bioreactor in which hematopoietic cell expansion and differentiation takes place. | 2011-01-06 |
| 20110003388 | METHODS OF MAKING ENHANCED, AUTOLOGOUS FAT GRAFTS - Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Compositions that are administered to a patient include a mixture of adipose tissue and stem cells so that the composition has a higher concentration of stem cells than when the adipose tissue was removed from the patient. | 2011-01-06 |
| 20110003389 | CELL CULTURE INSTRUMENT AND CELL CULTURE METHOD USING THE SAME - Provided is a cell culture instrument which has excellent operability while including a plurality of wells capable of holding cells. The cell culture instrument according to the present invention includes a base portion in which a well group including a plurality of first wells capable of holding cells is formed, and a frame portion vertically arranged around the well group of the base portion to form a second well being capable of holding a solution. | 2011-01-06 |
| 20110003390 | METHOD AND DEVICE FOR CELL CULTURE IN OPEN CONTINUOUS MODE - The present invention relates to the use of cell cultures in the open continuous mode, to a method for selecting static cell variants or cell variants which proliferate in suspension, to a culture substrate and to a device suitable for implementing this method. | 2011-01-06 |
| 20110003391 | SENSOR FILMS, METHODS FOR MAKING AND METHODS FOR MONITORING WATER-SOLUBLE POLYMER CONCENTRATIONS - A multiple-component sensor film includes a carrier polymer matrix and film reactants dispersed within the carrier polymer matrix. The carrier polymer matrix includes a carrier polymer, which includes hydroxypropyl cellulose polymer and the film reactants include an indicator and a reactant from the group of a buffer, a stabilizer, a masking agent, a solubilizer and an internal reference dye. Methods for making the multiple-component sensor film and methods for monitoring the concentration of water soluble polymers in aqueous media are also provided. | 2011-01-06 |
| 20110003392 | System and Method for Magnetically Concentrating and Detecting Biomarkers - System and method for capturing, concentrating, and detecting a diagnostic target in a liquid, comprising applying a magnetic field to a mixture comprising a co-aggregate in the liquid to provide a collected co-aggregate in the liquid, wherein the co-aggregate comprises a magnetic particle having a stimuli-responsive polymer attached thereto and a non-magnetic particle having a stimuli-responsive polymer and a diagnostic target attached thereto. | 2011-01-06 |
| 20110003393 | SYSTEMS AND METHODS FOR STUDYING INFLUENZA - The present invention generally relates to influenza and, in particular, to systems and methods for studying influenza viruses such as the influenza A virus. One aspect of the invention is generally directed towards systems and methods for determining the timescale dynamics of the tryptophan residue located in position 41 of the M2 proton channel of the influenza A virus, for instance, via nuclear magnetic resonance. This may be useful, for example, in determining whether a candidate drug is able to alter the dynamics of the tryptophan residue, and thus, whether the drug targets the M2 proton channel. | 2011-01-06 |
| 20110003394 | ENCODED MICROPARTICLES - An encoded microparticle including an optical substrate comprising a material that permits light to propagate therethrough. The optical substrate has an elongated body that extends in a direction along a central axis. The optical substrate includes an outer region that extends about the central axis. The encoded microparticle also includes an optically detectable code that is disposed within the optical substrate and extends along the central axis. The outer region surrounds the optically detectable code about the central axis. The optically detectable code is readable when the light propagates through the outer region and is at least one of reflected or filtered by the optically detectable code. Said at least one of reflected or filtered light propagates through the outer region to be detected for reading the optically detectable code. | 2011-01-06 |
| 20110003395 | SPECIFIC ANALYSIS OF ANALYTES USING REAGENT COMPOUNDS, LABELING STRATEGIES, AND MASS SPECTROMETRY WORKFLOW - Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry. | 2011-01-06 |
| 20110003396 | EXPLOSIVES DETECTION MARKERS - The present invention relates to a porphyrinogen based sensor having selective binding affinity for an explosive chemical. Upon binding of the target molecule, the porphyrinogen derivative undergoes a detectable adsorption and emission of electromagnetic radiation. | 2011-01-06 |
| 20110003397 | Solvatochromic functional monomer and the use thereof for chemosensing by solvatochromic molecular imprinting - The present invention relates to a solvatochromic functional monomer having the chemical structure as shown in the accompanying drawing (FIG. | 2011-01-06 |
| 20110003398 | ASSAY DEVICE COMPRISING SERIAL REACTION ZONES - An analysis device having at least one sample addition zone, at least one sink, and at least one flow path connecting the at least one sample addition zone and the at least one sink. The at least one flow path includes projections substantially vertical to the surface of the substrate and having a height (H), diameter (D) and reciprocal spacing (t | 2011-01-06 |
| 20110003399 | Tumor Necrosis Factor-Gamma - Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed. | 2011-01-06 |
| 20110003400 | METHODS AND SYSTEMS FOR GROUND AND SURFACE WATER SAMPLING AND ANALYSIS - The invention provides devices, methods, and kits for collection of dry samples from fluid samples such as ground or surface water. Devices of the invention include a casing including a water intake zone wherein the casing encloses, a fluid reservoir, a pump, a non-aqueous collection matrix cartridge, and a waste water conduit, wherein the water intake zone, the fluid reservoir, the pump, the non-aqueous collection matrix cartridge, and the waste water conduit are all operably linked in sequence. Methods for using the device of the invention are provided. Kits including the device of the invention or for use with the invention are also provided. | 2011-01-06 |
