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Micro-fluidic device

Subclass of:

422 - Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing

422050000 - ANALYZER, STRUCTURED INDICATOR, OR MANIPULATIVE LABORATORY DEVICE

422500000 - Miscellaneous laboratory apparatus and elements, per se

422501000 - Volumetric fluid transfer means, e.g., pipette, pipettor, etc.)

Patent class list (only not empty are listed)

Deeper subclasses:

Class / Patent application numberDescriptionNumber of patent applications / Date published
422504000 Liquid moving means 34
422503000 Plate design or structure 19
Entries
DocumentTitleDate
20110194994Chemical synthesis and analysis via intergrated or sequential photochemical and electrochemical processes for use in microfluidic, lab-on-a-chip, and green-chemistry applications - A microfluidic system comprising a plurality of photochemical reaction stages, the microfluidic system comprising a computational processor, a plurality of electrically-controllable photochemical reaction stages, and a series of controllable interconnections for connecting the photochemical reaction stages. In an implementation, the computational processor controls the plurality of electrically-controllable photochemical reaction stages and the controllable interconnections so as to implement a multi-step photochemical synthesis function.08-11-2011
20130078163Deterministic High-Density Single-Cell Trap Array - A microfluidic platform for single-cell capture, stimulation, and imaging. It passively traps 4,000 single cells on a 4.5 mm03-28-2013
20130078164Device for Forming Drops in a Microfluidic Circuit - The invention relates to a device (03-28-2013
20120183454HEAT-REDUCTION METHODS AND SYSTEMS RELATED TO MICROFLUIDIC DEVICES - The present relates to a system and method for preventing or reducing unwanted heat in a microfluidic of the device while generating heat in selected regions of the device. Current can be supplied to a heating element through electric leads that are designed so that the current density in the leads is substantially lower than the current density in the heating element. Unwanted heat in the microfluidic complex can be reduced by thermally isolating the electric leads from the microfluidic complex by, for example, running each lead directly away from the microfluidic complex. Unwanted heat can be removed from selected regions of the microfluidic complex using one or more cooling devices.07-19-2012
20130045144Micro-Fluidic System - A micro-fluidic system comprising a micro-fluidic channel, which has a wall provided with a hole, within which a closing portion of a closing element extends; when the closing portion is arranged within the micro-fluidic channel, the passage of the liquid along the channel is interrupted; by deforming the closing element by suction the closing portion may be lifted and therefore allow the passage of liquid along the micro-fluidic channel.02-21-2013
20130028812METHODS AND SYSTEMS FOR ON DEMAND DROPLET GENERATION AND IMPEDANCE BASED DETECTION - The present invention pertains to methods and systems for on demand droplet generation and impedance based detection. The microfluidic system can utilize an electrical sensor for detecting an electrical property of a fluid and for generating an electrical signal indicating a change in the electrical property of the fluid; a droplet generator coupled to the electrical sensor configured to generate the droplet from the fluid in response to the electrical signal from the electrical sensor; and a microfluidic channel coupled to the droplet generator for receiving the droplet. The method for generating droplets involves measuring an electrical property of the fluid, transmitting an electrical signal indicative of the electrical property, and forming the droplets from the fluid based on the electrical signal.01-31-2013
20130071304MICROFLUIDIC DEVICE - A micro-fluidic device includes a filter cabinet, a first filtering unit and a second filtering unit. The filter cabinet includes a first path and a second path branched from the first path. The first path and the second path are formed within the filter cabinet so that a sample containing different kinds of targets can flow through the first path and the second path. The first filtering unit is installed in an upstream portion of the first path to filter the different kinds of targets from the sample, the first filtering unit configured to guide the different kinds of targets toward the second path. The second filtering unit is installed in the second path to receive the different kinds of targets from the first filtering unit and to filter the different kinds of targets on a size-by-size basis.03-21-2013
20110038766MICROCHANNEL AND ANALYZING DEVICE - A microchannel 02-17-2011
20110044864SUPPORTING UNIT FOR MICROFLUID SYSTEM - The present invention provides a supporting unit of microfluid system having a smaller restriction on the number of the steps and capacity of the reaction and analysis that can be produced easily, and a microfluid-system supporting unit allowing mounting of complicated fluid circuits densely. The present invention relates to a microfluid-system supporting unit, comprising a first supporting plate and at least one hollow filament constituting the channel of the microfluid system, wherein the hollow filament is placed on the first supporting plate in any shape and a particular internal region of the hollow filament has a function.02-24-2011
20110104025METHOD FOR PRODUCING RECONFIGURABLE MICROCHANNELS - A microfluidic device, including a microfluidic network, including: a) two parallel plates each including one or more electrodes, b) at least one channel, arranged between the two plates, made from a material obtained by solidification or hardening of a material of a first fluid, and c) a mechanism varying a physical parameter of the material constituting walls of the channel so as to cause the material to pass at least from the liquid state to the solid state.05-05-2011
20110076204PINCH VALVE AND METHOD FOR MANUFACTURING SAME - A pinch valve, a chip including a pinch valve of this type, a peristaltic pump including a pinch valve of this type and a method for manufacturing same. The pinch valve includes a first substrate, a second substrate, and a third substrate, the third substrate being farmed from an elastic material and situated between the first and second substrates, the first substrate adjoining the third substrate and having at least one first recess on the side adjacent to the third substrate, the second substrate adjoining the third substrate and having at least one second recess on the side adjacent to the third substrate, the first recess and the second recess being situated at least partially opposite each other.03-31-2011
20110142734DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT - The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.06-16-2011
20110104024MICROVALVE AND SEALING DEVICE FOR USE IN A MICROFLUIDICS SYSTEM, AND METHOD FOR THE PRODUCTION THEREOF - A microvalve for controlling fluid flows, and a sealing device for sealing cavities in a microfluidic system, particularly in a lab-on-a-chip system, and a method for the production thereof. A sealing surface of a valve body, or a sealing element, respectively, rests on a sealing surface of a substrate and is pressed against the sealing surface of the substrate in a fluid-tight manner by means of a clamping element. The clamping element and/or the valve body, or the sealing element, respectively, are at least partially elastic.05-05-2011
20110300034Disposable, High Pressure Microfluidic Chips - An injection molding process for the fabrication of disposable unitary plastic microfluidic chips with a cycle time on the order of minutes is described. The microfluidic chips feature novel, integrated, reversible, standardized, ready-to-use inter-connects that enable operation at pressures not before realized with microfluidic chips.12-08-2011
20110286895MICROVALVE DEVICE AND METHOD OF MANUFACTURING THE SAME - A microvalve device comprises: a first substrate having a first surface, wherein at least one fluidic channel are formed into the first surface of the first substrate; and at least one valve seat are formed in the fluidic channel; a second substrate having a second surface, the second substrate comprising at least one air channel and at least one air chamber formed on the second surface of the second substrate, wherein the air chamber is connected to the air channel; and an elastic film interposed between the first substrate and the second substrate, where an upper portion of the valve seat is lower than the first surface of the first substrate.11-24-2011
20120107194CHANNEL AND METHOD OF FORMING CHANNELS - A device is made by forming sacrificial fibers on a substrate mold. The fibers and mold are covered with a first material. The substrate mold is removed, and the covered fibers are then removed to form channels in the first material.05-03-2012
20110171086MICROFLUIDIC DEVICE - A microfluidic device is provided, the microfluidic device comprising: a plurality of chambers (07-14-2011
20120195809APPARATUS AND METHODS FOR MICROFLUIDIC APPLICATIONS - Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape.08-02-2012
20120093700SILICON SUBSTRATE OPTIMIZATION FOR MICROARRAY TECHNOLOGY - A micro device includes a substrate and a structure configured to bind to an object or a material, or not to bind to an object or material. The structure has a roughness based on a roughness of the object or material. For example, a microarray includes a substrate and a well positioned in the substrate and configured to bind to a type of bead. The well has a roughness based on a roughness of the type of bead to which the well is configured to bind. The roughness of the well is controlled by controlling a position and number of striations in the side of the well. In another example, a moveable component of a micro device may have a roughness different from a roughness of an adjacent component, to reduce the likelihood of the moveable component sticking to the adjacent component.04-19-2012
20130121892POLYMERIC SUBSTRATE HAVING AN ETCHED-GLASS-LIKE SURFACE AND A MICROFLUIDIC CHIP MADE OF SAID POLYMERIC SUBSTRATE - The present invention relates to a polymeric substrate having a glass-like surface, in particular an etched-glass-like surface and to a chip made of at least one such polymeric substrate. The present invention also relates to a method of providing a polymeric substrate with an etched-glass-like surface. Moreover, the present invention relates to a kit for manufacturing a chip using such polymeric substrate. Moreover, the present invention relates to the use of a polymeric substrate having a glass-like surface, in particular an etched-glass-like surface for manufacturing a chip.05-16-2013
20120195810MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION - The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader.08-02-2012
20120141337FLUORESCENCE DETECTOR, FILTER DEVICE AND RELATED METHODS - A microfluidic filter is disclosed. The filter can be used with onchip fluid filtration such as whole blood filtration for microfluidic blood analysis. The filter is able to filter the necessary volume of fluid and in particular blood in an acceptable time frame.06-07-2012
20130129581MICRODROPLET-PRODUCING APPARATUS - [Name of the Document] The present invention provides an apparatus for producing micro liquid drops through fine channels which can produce a large amount of micro liquid drops at low costs in an efficient manner. The apparatus for producing micro liquid drops according to the present invention includes a fine channel substrate and a holder for holding the fine channel substrate. The fine channel substrate has a micro liquid drop discharge outlet formed at the center thereof; a plurality of micro liquid drop producing sections which are connected to the micro liquid drop discharge outlet via the fine channels and disposed on the respective circumference of M circles or polygons arranged around the micro liquid drop discharge outlet; first-liquid drawing inlets which are disposed on the circumference of a circle or polygon arranged around the micro liquid drop discharge outlet; up-to-Nth-liquid drawing inlets (N is an integer equal to two or greater, M≦N−1) which are disposed on the respective circumference of circles or polygons arranged sequentially outward; and the fine channels through which the first- to Nth-liquids are supplied to the plurality of micro liquid drop producing sections. The holder for holding the fine channel substrate has a multi-pipe structure which includes N annular channels for distributing an equal flow of the first- to Nth-liquids to the drawing inlet for each liquid in the fine channel substrate.05-23-2013
20110008223FLUID INTERFACE CARTRIDGE FOR A MICROFLUIDIC CHIP - An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.01-13-2011
20110064628MICROFLUIDIC CHIP FEATURES FOR OPTICAL AND THERMAL ISOLATION - A microfluidic chip includes microfluidic channels, elements for thermally and optically isolating the microfluidic channels, and elements for enhancing the detection of optical signal emitted from the microfluidic channels. The thermal and optical isolation elements may comprise barrier channels interposed between adjacently-arranged pairs of microfluidic channels for preventing thermal and optical cross-talk between the adjacent microfluidic channels. The isolation element may alternatively comprise reflective film embedded in the microfluidic chip between the adjacent microfluidic channels. The signal enhancement elements comprise structures disposed adjacent to the microfluidic channels that reflect light passing through or emitted from the microfluidic channel in a direction toward a detector. The structures may comprise channels or a faceted surface that redirects the light by total internal reflection or reflective film material embedded in the microfluidic chip.03-17-2011
20110085949Microfluidic device, composition and method of forming - A composition made of at least 60 wt. % of a thermoplastic elastomer resin and additives that are solid at least from 0-50° C., that has a Shore A hardness that is less than about 50 bears a patterned surface, the pattern comprising at least one microfluidic channel having a cross-sectional dimension smaller than 100 microns is a substrate for forming a microfluidic device. The chief advantages of such compositions are: its ability to bond in a sealing manner to smooth surfaces of many different compositions, its ease of manufacture and microstructure patterning, and its general impermeability to liquids.04-14-2011
20110044863MICRO FLUID DEVICE - The present invention provides a microfluidic device with a micro-pump system in which the production process is simplified and the device is further downsized. A microfluidic device 02-24-2011
20130164191MICROFLUIDIC DEVICES WITH INTEGRATED RESISTIVE HEATER ELECTRODES INCLUDING SYSTEMS AND METHODS FOR CONTROLLING AND MEASURING THE TEMPERATURES OF SUCH HEATER ELECTRODES - The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed heater electrodes, wherein the heater electrodes are part of a multiplex circuit including a common lead connecting the heater electrodes to a power supply, each of the heater electrodes being associated with one of the microfluidic channels. The microfluidic device also includes a control system configured to regulate power applied to each heater electrode by varying a duty cycle, the control system being further configured to determine the temperature of each heater electrode by determining the resistance of each heater electrode.06-27-2013
20130164192Microfluidic Capsule - A microfluidic capsule (06-27-2013
20110165037INTERFACES THAT ELIMINATE NON-SPECIFIC ADSORPTION, AND INTRODUCE SPECIFIC INTERACTIONS - A microfluidic system comprising a microchannel, a carrier fluid comprising a fluorinated oil in the microchannel, at least one plug comprising an aqueous plug-fluid in the microchannel and substantially surrounded on all sides by the carrier-fluid, and a fluorinated surfactant comprising a functional group capable of selectively binding a target molecule is disclosed. A compound for use therewith and a method of synthesizing a fluorinated surfactant are also provided.07-07-2011
20110135546MICROFLUIDIC FOIL STRUCTURE FOR METERING OF FLUIDS - The invention relates to a microfluidic device for metering liquids into a microfluidic network. The microfluidic channels or chambers are at least partly formed by the introduction of suitable structures into a film above the substrate carrier, so that at least some of the flow of fluid through the network takes place above the plane of the substrate. In order to form a stable channel structure or chamber structure in the film, it is envisaged that in the edge zone between the unattached and attached portions a wedge of material is formed by the viscous flow of the film material as the film is bonded to the substrate, this wedge forming a transition between the chamber wall and the substrate and raising the chamber wall above the plane of the substrate. In one method of producing a finished microfluidic structure a flat planar film is laminated onto a flat sheet-like substrate. During the lamination a mask having at least one recess or opening is pressed onto the film and onto the substrate under pressure and/or under the effect of heat. The film is thereby brought to a temperature at which there is a viscous flow of film and/or substrate medium into the region of the recess or opening, so that a wedge of material is formed and the film bulges up in the region of the recess to form a chamber. The invention further relates to methods of metering at least one liquid in a microfluidic network, in which a capillary stop is overcome by actuating the film, the film being wetted as the capillary stop is removed.06-09-2011
20120121481SCALE-UP OF FLOW-FOCUSING MICROFLUIDIC DEVICES - Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.05-17-2012
20120121480MICROFLUIDIC DEVICES FOR RELIABLE ON-CHIP INCUBATION OF DROPLETS IN DELAY LINES - The present invention relates generally to droplet creation, fusion and sorting, and incubation for droplet-based microfluidic assays. More particularly, the present invention relates to delay-lines, which allow incubation of reactions for precise time periods. More particularly, the present invention relates to delay lines for incubations up to three hours, while reducing back-pressure and dispersion in the incubation time due to the unequal speeds with which droplets pass through the delay line.05-17-2012
20110305607MICROFLUIDIC DEVICE HAVING MICROVALVE - A microfluidic device including a microvalve includes a first substrate, a second substrate facing the first substrate, an elastic film between the first and second substrates, a microfluidic channel on the second substrate, a valve seat of the second substrate protruding in the microfluidic channel, and a fine structure on a surface of the elastic film, facing the valve seat and which contacts the valve seat when the microvalve is operated.12-15-2011
20120301372MICROCHIP AND METHOD OF PRODUCING MICROCHIP - A microchip is provided. The microchip (A) includes a substrate structure including a fluid channel (11-29-2012
20120301371MICROFLUIDIC ELEMENT FOR ANALYZING A LIQUID SAMPLE - A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.11-29-2012
20120114534MICRO-FLUIDIC SYSTEM AND THE USE THEREOF - The invention relates to a micro-fluidic system comprising: a. a planar micro-fluidic device comprising a plurality of inlets and at least one outlet; b. a holder comprising a first part being provided with a plurality of channels having first ends and second ends, the holder comprising a fixing means for clamping the micro-fluidic device; c. sealing means being arranged to connect the plurality of inlets and the at least one out-let of the micro-fluidic device to the second ends of the plurality of channels, the sealing means being arranged such that a surface contact between the micro-fluidic device and the sealing means and a surface contact between the sealing means and the first part of the holder is established characterized in that the first part of the holder is optionally provided with a first recess for accommodating the planar micro-fluidic device, the second ends of the plurality of channels being located within the optional first recess and at least one second recess is provided for accommodating the sealing means, the second ends of the plurality of channels being located in the at least one second recess. The present invention also relates to the use of such a micro-fluidic systems at high pressures and high temperatures.05-10-2012
20120063971INERTIAL PARTICLE FOCUSING SYSTEM - An inertial particle focusing system for use with a particle having diameter (a) includes a curved microchannel into a substrate, said microchannel having a radius of curvature (r), and a channel hydraulic diameter (D03-15-2012
20130156657DEVICE AND METHOD FOR MANUFACTURING THE SAME - It is an object of this invention to prevent a resistor material and an electrode material from diffusing and suppress variation in electric resistance. In a device including a plurality of metal layers of different compositions on a substrate and a second structure made of a material, such as glass paste, requiring a firing process at the time of formation, an intermediate layer is formed between a first metal layer and a second metal layer forming the first structure. The intermediate layer is of an intermetallic compound including one or more metallic elements in the first metal layer and one or more metallic elements in the second metal layer. The melting point of the intermetallic compound is higher than a firing temperature when the second structure is formed, and the intermetallic compound is produced at a temperature higher than the firing temperature for forming the second structure.06-20-2013
20120063972DEVICE HAVING REGIONS OF DIFFERING AFFINITIES TO FLUID, METHODS OF MAKING SUCH DEVICES, AND METHODS OF USING SUCH DEVICES - A microfluidic device comprising a first surface portion and a first sample retaining element, which have differing affinities to a fluid, and a method comprising supplying a sample to such a device. In some embodiments, the differing affinity is a result of plasma, ion embedding, surface charging, chemical, optical, electronic and/or electromagnetic treatment. Also, a microfluidic device comprising at least one microcapillary device having a sample retaining element, at least one surface of which exhibits hydrophobicity, hydrophilicity, electromagnetic force exertion and electrostatic force exertion. Also, a microfluidic device comprising a first element having a hydrophilic pattern comprising at least a first sample retaining element. Also, a method comprising supplying a sample to a channel between a first element and a second element, and inducing in the first element at least one hydrophilic pattern by electrets or by internal or external electrodes to provide a charged surface.03-15-2012
20120107195METHOD OF PRODUCING MICROFLUIDIC DEVICES BASED ON A POLYMER - Disclosed is a method for producing a polymer-based microfluidic device, including: forming a microstructure on a lower polymer matrix; coating the lower polymer matrix with TiO05-03-2012
20120164036MICROFLUIDIC DEVICES AND USES THEREOF - The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The design of the cartridges, microchips, and pneumatic manifolds can allow for the use of magnetic forces to capture magnetic beads in a chamber formed between the microchip and the cartridge or a chamber within the microchip. The devices of the invention can be used for mRNA amplification and purification.06-28-2012
20120258025MICROFABRICATED DEVICES WITH COATED OR MODIFIED SURFACE AND METHOD OF MAKING SAME - A microfabricated device or component thereof, such as microfluidics or nanofluidics device having a uniform non-wetting or non-absorbing polymeric coating or surface modification formed on a surface thereof by ionisation or activation technology such as plasma processing, to produce a surface energy of less than 15 mNm10-11-2012
20120230887DEVICES AND METHODS FOR INTERFACING MICROFLUIDIC DEVICES WITH MACROFLUIDIC DEVICES - The present disclosure is directed generally to devices and methods with the purpose of interfacing microfluidic devices with macrofluidic devices. Specifically, the present disclosure includes the de-09-13-2012
20120230886Microfluidic Cytochemical Staining System - The present invention provides devices and associated methods to facilitate multiplexed staining on a slide. The use of multiplexed staining on a single slide allows for more accurate disease diagnosis while also conserving sample. A PDMS based cytology overlay was created that is capable of coupling on-chip morphological, cytochemical, and immunological staining. Morphological and cytochemical staining of blood smears, along with immunostaining of lymph node imprints, was carried out to demonstrate the application of this microfluidic cytology chip (μCC) device.09-13-2012
20110123413SURFACES, INCLUDING MICROFLUIDIC CHANNELS, WITH CONTROLLED WETTING PROPERTIES - The present invention generally relates to coating materials, including photoactive coating materials. In some aspects of the invention, a sol-gel is provided that can be formed as a coating on a microfluidic channel. One or more portions of the sol-gel can be reacted to alter its hydrophobicity, in some cases. For instance, in one set of embodiments, a portion of the sol-gel may be exposed to light, such as ultraviolet light, which can be used to induce a chemical reaction in the sol-gel that alters its hydrophobicity. In one set of embodiments, the sol-gel can include a photoinitiator, that upon exposure to light, produces radicals. Optionally, the photoinitiator may be conjugated to a silane or other material within the sol-gel. The radicals so produced may be used to cause a polymerization reaction to occur on the surface of the sol-gel, thus altering the hydrophobicity of the surface. In some cases, various portions may be reacted or left unreacted, e.g., by controlling exposure to light (for instance, using a mask). Such treated surfaces within a microfluidic channel may be useful in a wide variety of applications, for instance, in the creation of emulsions such as multiple emulsions.05-26-2011
20120269701FLUIDIC CONNECTORS AND MICROFLUIDIC SYSTEMS - Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.10-25-2012
20120321536MICROFLUIDIC DEVICE COMPRISING A BIODEGRADABLE MATERIAL AND METHOD OF MAKING SUCH A MICROFLUIDIC DEVICE - A microfluidic device comprising a biodegradable material comprises, according to one embodiment, a body including one or more channels extending therethrough for passage of a fluid, where the body includes a first preform and a second preform bonded to the first preform. The first preform comprises a biodegradable material derived from a plant and the second preform defines a wall of each of the channels. According to another embodiment, the microfluidic device comprises a body having one or more channels extending therethrough for passage of a fluid, where the body comprises a biodegradable material and is a monolithic body including no seams.12-20-2012
20120288422GLASS MICRO FLUIDIC DEVICE - A method of making a microfluidic device, includes: providing an optically transparent bottom substrate and an optically transparent top substrate, each made of glass. Recesses are made in the top substrate and the top and bottom substrates are bonded together. Then, material is removed from the top substrate to expose the recesses, and a lid is attached to the top substrate so as to cover the recesses whereby channels are formed. At least that surface of the lid facing towards the recesses in the top substrate has a surface roughness of <5 nm, preferably <2 nm. A microfluidic device, including a body of an optically transparent material, and at least one channel extending inside the body, the channels having a bottom surface, a top surface and side walls is also described. The top and bottom surfaces both exhibit surface a roughness <5 nm, preferably <2 nm.11-15-2012
20130115148Microchip and Method of Using the Same - A microchip including a first substrate with a groove formed on a substrate surface or a pass-through hole passing in a thickness direction of the substrate, and one or more second substrates laminated on a surface of the first substrate; the microchip including an optical measurement cuvette consisting of a space configured by the groove or the pass-through hole, and a substrate surface of the second substrate; wherein a side wall surface of the second substrate is positioned on an inner side than a side wall surface of the first substrate in at least one part of a side wall surface of the microchip, and a method of using the same are provided.05-09-2013
20130149214MICROVASCULAR FLUIDIC DEVICES, SYSTEMS AND METHODS RELATED THERETO - Microfluidic devices and processes are provided that relate to microvascular-sized systems configured to identify specific pathophysiological characteristics related to the interactions between, for example, blood cells and endothelial cells combined with geometric and flow constraints of microvasculature. The device may include at least one layer, the layer including a plurality of microvascularized-sized fluidic channels, the plurality of microfluidic channels being disposed in a geometric pattern. The layer may be composed of a hydrogel and/or a silicon elastomer. The channels may include subchannels of different lengths.06-13-2013
20130149215SYSTEM-IN-PACKAGE PLATFORM FOR ELECTRONIC-MICROFLUIDIC DEVICES - The present invention relates to an integrated electronic-microfluidic device an integrated electronic-microfluidic device, comprising a semiconductor substrate (06-13-2013
20120275971MICROCHIP - A microchip includes a fluid circuit defined by a space formed in the microchip. A liquid present in the fluid circuit is moved to a desired position in the fluid circuit. The fluid circuit includes a first channel passing the liquid and a second channel passing the liquid passed through the first channel, and the first channel is arranged such that a first end corresponding to an end of the second channel is spaced apart from an inner wall of the second channel.11-01-2012
20120009098MICROFLUIDIC DEVICE WITH A FILTER - A microfluidic device with a filter includes a substrate; a flowpath including a well formed in the substrate in fluid communication with a channel formed in the substrate; and a filter disposed across the flowpath and associated with the channel.01-12-2012
20120027648INTERFACING CAPS FOR MICROFLUIDIC DEVICES AND METHODS OF MAKING AND USING THE SAME - An interfacing cap for a reagent storage vessel is provided. The interfacing cap comprises a partitioning element having a structure corresponding to an opening of the reagent storage vessel, a projection fitting disposed on the partitioning element, a holder element, and a puncturing element coupled to the projection fitting.02-02-2012
20130209326MICROFLUIDIC CARTRIDGE FOR PROCESSING AND DETECTING NUCLEIC ACIDS - A microfluidic cartridge, configured to facilitate processing and detection of nucleic acids, comprising: a top layer comprising a set of cartridge-aligning indentations, a set of sample port-reagent port pairs, a shared fluid port, a vent region, a heating region, and a set of Detection chambers; an intermediate substrate, coupled to the top layer comprising a waste chamber; an elastomeric layer, partially situated on the intermediate substrate; and a set of fluidic pathways, each formed by at least a portion of the top layer and a portion of the elastomeric layer, wherein each fluidic pathway is fluidically coupled to a sample port-reagent port pair, the shared fluid port, and a Detection chamber, comprises a turnabout portion passing through the heating region, and is configured to be occluded upon deformation of the elastomeric layer, to transfer a waste fluid to the waste chamber, and to pass through the vent region.08-15-2013

Patent applications in class Micro-fluidic device

Patent applications in all subclasses Micro-fluidic device