Class / Patent application number | Description | Number of patent applications / Date published |
800288000 | Nonplant protein is expressed from the polynucleotide | 52 |
20090025106 | C-TERMINALLY TRUNCATED INTERFERON - The invention described herein provides a C-terminally truncated interferon having enhanced biological activity and the polynucleotides encoding such interferon. Also provided are methods for producing and using such truncated interferon. | 01-22-2009 |
20090083883 | D-Amino Acid Selection For Soybean - The present invention relates to improved methods and means for transformation of soybean ( | 03-26-2009 |
20090094715 | METHODS OF USE OF ANTIBODIES WITH REDUCED IMMUNOGENICITY OR TOXICITY - Humanized antibodies which bind the NR-LU-13 antigen, conjugates containing such antibodies, and their use in pretargeting methods and conventional antibody therapy and immunodiagnosis are provided. | 04-09-2009 |
20090126045 | Transgenic Plant for Producing Polyglutamic Acid - A method for preparing a transgenic plant for producing polyglutamic acid and a transgenic method prepared by this method are provided. The method of the present invention comprises introducing a nucleic acid encoding the polyglutamic acid synthase A (pgsA), a nucleic acid encoding the polyglutamic acid synthase B (pgsB) and a nucleic acid encoding the polyglutamic acid synthase C (pgsC) into a plant. | 05-14-2009 |
20090282583 | METHODS FOR THE PRODUCTION OF INSULIN IN PLANTS - Commercial production of human insulin can be effected via transgenic expression in plant seeds. Thus, levels of insulin accumulation exceeding 0.1% of total cellular protein can be achieved recombinantly, through expression of the insulin with a single-chain antibody as a fusion partner. Production in seeds offers flexibility in storage and shipment of insulin as a raw material, and insulin retains its activity upon extraction from stored seed. Further, the amount of biomass subjected to extraction is limited, due to the relatively low water content of plant seeds. | 11-12-2009 |
20090293155 | METHOD FOR PERFORMING HOMOLOGOUS RECOMBINATION IN PLANTS - The invention relates to modified restriction enzymes capable of being used for promoting homologous recombination in organisms, in particular plants, making it possible to either target gene integration or excise unwanted DNA sequences in the genome of said organisms. | 11-26-2009 |
20100031394 | Human Blood Proteins Expressed in Monocot Seeds - The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, and to methods of making these isolated blood proteins and to therapeutic compositions comprising them. | 02-04-2010 |
20100083403 | PRODUCTION OF PEPTIDES AND PROTEINS BY ACCUMULATION IN PLANT ENDOPLASMIC RETICULUM-DERIVED PROTEIN BODIES - A nucleic acid molecule is disclosed as containing a first nucleic acid sequence comprising a nucleotide sequence that encodes γ-zein protein, or a fragment thereof capable of directing and retaining a protein towards the endoplasmic reticulum (ER) of a plant cell; a second nucleic acid sequence containing a nucleotide sequence that encodes an amino acid sequence that is specifically cleavable by enzymatic or chemical means; and a third nucleic acid sequence containing the nucleotide sequence that encodes a peptide or protein of interest. Methods of using this nucleic acid molecule for transforming host plant cells and producing the peptide or protein of interest are also disclosed. | 04-01-2010 |
20100122378 | TRUNCATED ALTERNAN SUCRASE CODING NUCLEIC ACID MOLECULES - The present invention relates to nucleic acid molecules which code for a truncated alternan sucrase. The invention further relates to truncated alternan sucrases, to vectors, to host cells and to plant cells transformed with the nucleic acid molecules described, and to plants comprising these cells. The present invention furthermore relates to novel alternan polymers with advantageous properties and to methods for their production. | 05-13-2010 |
20100186120 | ORGANIC COMPOUNDS - Method for heterologous protein production in plant cell plastids comprising introducing into plant cells nucleic acid components that encode heterologous proteins under the control of promoters operative in plastids, vectors, host cells, plants and uses thereof. | 07-22-2010 |
20100287670 | PROTEIN EXPRESSION SYSTEM - The inventions is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (‘CPMV-HT’) based protein expression system. | 11-11-2010 |
20100299787 | N-TERMINAL XA27 SIGNAL ANCHOR AND ITS USE FOR LOCALIZATION OF FUSION PROTEINS - The present application is directed to a functional signal anchor that localizes a fusion protein to the apoplast of vascular elements in plants. The signal anchor is useful for engineering secretory proteins to the cell wall and or/apoplast of plant cells. The signal anchor is also useful for producing secretory proteins in transgenic plant cells in a bioreactor. | 11-25-2010 |
20100313307 | PROTEIN PRODUCTION AND STORAGE IN PLANTS - A transgenic dicotyledonous plant having a deficiency of one or more plant seed storage proteins, further having a transgenic polynucleotide construct comprising an open reading frame operably linked to a storage protein promoter and an ER signal sequence. The polynucleotide construct encodes a protein product that can accumulate at high levels in the seed. Also provided are methods of producing a heterologous protein in a plant seed. | 12-09-2010 |
20100313308 | PLANTS HAVING ALTERED GROWTH AND/OR DEVELOPMENT AND A METHOD FOR MAKING THE SAME - The present invention relates generally to the field of molecular biology and concerns a method for altering variouse aspects of plant growth and/or development by modulating expression in a plant of a nucleic acid encoding an UBiquitin-Specific Protease (UBP) of the UBP15 subfamily or a homologue thereof. The present invention also concerns plants having modulated expression of a nucleic acid encoding a UBP 15 or a homologue thereof, which plants have altered growth and/or development relative to corresponding wild type plants or other control plants. The invention also provides constructs useful in the methods of the invention. | 12-09-2010 |
20110047648 | Promoters and methods thereof - A promoter, which may be used to transform a plant and/or express a gene substantially uniformly in substantially all organs and/or tissues of a plant, and which may include a constitutive expression promoter for transforming a monocot plant. A vector including a promoter, which may include a recombinant plant expression vector. A method of producing a target protein using a vector, and a method of producing a transformed cell and/or plant using a vector. A transformed plant, a transformed seed and a transformed cell are included, which may be formed by the method of producing the same using a vector. A PCR primer for a promoter is provided. | 02-24-2011 |
20110047649 | NITROGEN RESPONSIVENESS IN PLANTS THROUGH THE EXPRESSION OF PATHWAYS FOR THE FORMATION AND CATABOLISM OF NOVEL N-RICH COMPOUNDS - The invention provides for the regulation of opine synthesis and catabolism providing improved nitrogen responsiveness, utilizing opine synthase and oxidase nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering nitrogen utilization and/or uptake in plants. The invention further provides recombinant expression cassettes, host cells and transgenic plants. | 02-24-2011 |
20110055976 | Method Of Protease Production In Plants - A process of producing a protease in a plant or in plant cells, comprising (a) providing a plant comprising a heterologous nucleotide sequence comprising a coding sequence encoding a fusion protein, said fusion protein comprising: an apoplast or plastid signal peptide; a SUMO protein or a derivative of a SUMO protein; and a zymogen of said protease, and (b) expressing said fusion protein. | 03-03-2011 |
20110067146 | MAMMALIAN-TYPE GLYCOSYLATION IN PLANTS BY EXPRESSION OF NON-MAMMALIAN GLYCOSYLTRANSFERASES - The present invention relates to non-mammalian β-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian β-1,4-galacto-syltransferase and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian β-1,4-galactosyltransferases. | 03-17-2011 |
20110162106 | PLANT EXPRESSION CONSTRUCTS COMPRISING AND USES THEREOF - Methods of expressing a molecule of interest in a plant are disclosed. One method comprises contacting roots of the plant in a solution comprising at least one Geminivirus based expression construct so as to allow the at least one Geminivirus based expression construct to be absorbed by the roots, the expression construct comprising a polynucleotide encoding the molecule of interest, and further the expression construct being capable of systemic symptomless spread in a plant host, thereby expressing a molecule of interest in a plant. Expression constructs capable of systemic symptomless spread in a host plant are also disclosed. | 06-30-2011 |
20110203016 | PROCESS FOR PRODUCING PLANT STORAGE ORGAN WITH HIGH PRODUCTION OF RECOMBINANT PROTEIN AND NOVEL RECOMBINANT PROTEIN - The present invention provides a method for highly producing a recombinant protein in a plant storage organ and a GLP-1 derivative. The plant storage organ in which the recombinant protein is highly produced is obtained by transformation with the use of a vector which comprises a recombinant protein gene, a cytokinin-related gene, a drug-resistant gene and a removable DNA element, in which the cytokinin-related gene and the drug-resistant gene exist in the positions so that they can behave together with the DNA element, while the recombinant protein to be expressed in the plant storage organ exists in the position so that it would not behave together with the DNA element. The GLP-1 is produced by using the method, and a derivative having been stabilized against enzymatic digestion is further provided. | 08-18-2011 |
20110252507 | TRANSGENIC PLANTS USED AS A BIOREACTOR SYSTEM - The present invention relates generally to the use of plants as bioreactors for the production of molecules having useful properties such as inter alia polymers, metabolites, proteins, pharmaceuticals and nutraceuticals. More particularly, the present invention contemplates the use of grasses, and even more particularly C4 grasses, such as sugarcane, for the production of a range of compounds such as, for example, polyhydroxyalkanoates, pHBA, vanillin, indigo, adipic acid, 2-phenylethanol, 1,3-propanediol, sorbitol, fructan polymers and lactic acid as well as other products including, inter alia, other plastics, silks, carbohydrates, therapeutic and nutraceutic proteins and antibodies. The present invention further extends to transgenic plants and, in particular, transgenic C4 grass plants, capable of producing the compounds noted above and other products, and to methods for generating such plants. The ability to utilize the high growth rate and efficient carbon fixation of C4 grasses is advantageous, in that it obviates the significant growth penalties observed in other plants, and results in high yields of desired product without necessarily causing concomitant deleterious effects on individual plants. In addition, the C4 grass, sugarcane, is particularly advantageous, as in addition to the features common to all C4 grasses, this plant accumulates sucrose. This sucrose store provides a ready supply of carbon based compounds and energy which may further obviate any deleterious effects on the growth of the plant associated with the production of the product. The present invention provides, therefore, a bioreactor system comprising a genetically modified plant designed to produce particular metabolic or biosynthetic products of interest. | 10-13-2011 |
20110283418 | Transgenic Plants Having Altered Nitrogen Metabolism - Polynucleotides are disclosed which are capable of enhancing yield of a plant transformed to contain such polynucleotides. Also provided are methods of using such polynucleotides and transgenic plants and agricultural products, including seeds, containing such polynucleotides as transgenes. | 11-17-2011 |
20110321196 | Nucleic Acid Sequences Encoding Proteins Associated with Abiotic Stress Response - The present invention pertains transgenic plant cells and mature plants comprising Oxidoreductase Stress Related Proteins (ORSRP) resulting in increased tolerance and/or resistance to environmental stress as compared to non-transformed wild type cells and methods of producing such plant cells or plants. Further object of the present invention are isolated ORSRPs or ORSRP encoding nucleic acids from plants. | 12-29-2011 |
20120005782 | CHEMICALLY INDUCIBLE CUCUMBER MOSAIC VIRUS PROTEIN EXPRESSION SYSTEM - The invention relates to a novel chemically inducible plant viral amplicon (CMViva) expression system that permits controllable, high level expression of foreign genes in plant hosts. This system employs agro-infiltration of plants to provide a transient production of a protein of interest, such as a human blood protein. This system provides a major advantage over existing plant expression systems because it allows for consistent expression of foreign or heterologous proteins in plant hosts. | 01-05-2012 |
20120011619 | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 01-12-2012 |
20120017336 | TRANSGENIC ALOE PLANTS FOR PRODUCTION OF PROTEINS AND RELATED METHODS - The present inventions provide transgenic aloe plants and recombinant constructs for transforming aloe plants, aspects of which, may be applied to other monocots. The recombinant constructs may include one or more DNA sequences encoding mammalian proteins and at least one promoter capable of directing the expression of recombinant proteins in an aloe plant. The present inventions also provide methods for constructing and reproducing a transgenic aloe plant. The present inventions include methods for transfection of an aloe plant with several genes of interest simultaneously. The aloe plant production methods of the inventions may provide the potential to inexpensively and more safely mass-produce some biologically active compounds including biopharmaceuticals for disease therapy, diagnosis and prevention, and is more accessible to the less affluent countries. The aloe plant production methods may also produce proteins for cosmetics. | 01-19-2012 |
20120036596 | MAMMALIAN-TYPE GLYCOSYLATION IN PLANTS BY EXPRESSION OF NON-MAMMALIAN GLYCOSYLTRANSFERASES - The present invention relates to non-mammalian β-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian β-1,4-galacto-syltransferase and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian β-1,4-galactosyltransferases. | 02-09-2012 |
20120042417 | ENHANCED ACCUMULATION OF CAROTENOIDS IN PLANTS - The present invention relates to polynucleotides and their use in methods of increasing the carotenoid content of seeds. In particular the invention provides a polynucleotide comprising: (a) a region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence derived from a bacterium which sequence encodes a carotene desaturase; and (iii) a transcription termination region; and (b) a further region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence encoding a phytoene synthase which sequence is derived from maize ( | 02-16-2012 |
20120096591 | Identification and Validation of Novel Targets for Agrochemicals - The invention relates to a method for identifying and validating plant targets for agrochemicals, comprising the steps of determining gene or protein expression profiles in function of the progression of an essential biological process in a plant subsequent downregulation of expression of said gene or protein in a plant cell. More particularly, the effects of downregulation of the candidate target gene were directly monitored on plants locally infected with a vector mediating viral induced gene suppression in that infected plant area. The invention also relates to isolated plant genes encoding proteins involved in plant growth and development. The invention also relates to plants tolerant to agrochemicals such as herbicides or pesticides. | 04-19-2012 |
20120144530 | Optimized expression of glyphosate resistance encoding nucleic acid molecules in plant cells - A nucleic acid molecule encoding a 5-enolpyruvyl-3-phosphoshikimic acid synthase (EPSPS) that provides resistance to glyphosate is provided, that has been optimized for expression in both monocotyledonous and dicotyledonous plants and preferably in soybeans. Methods of use are also provided. | 06-07-2012 |
20120204292 | STRESS RESISTANT PLANTS - Stress tolerance in plants and plant cells is achieved by using nucleotide sequences encoding enzymes involved in the NAD salvage synthesis pathway and/or the NAD de novo synthesis pathway from fungal or yeast like organisms other than | 08-09-2012 |
20120210466 | MAMMALIAN-TYPE GLYCOSYLATION IN PLANTS BY EXPRESSION OF NON-MAMMALIAN GLYCOSYLTRANSFERASES - The present invention relates to non-mammalian β-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further relates to transformed plants and plant cells expressing non-mammalian β-1,4-galacto-syltransferase and methods to produce glycoproteins with altered and preferably mammalian-type glycosylation. The invention additionally provides nucleic acid molecules and expression vectors of non-mammalian β-1,4-galactosyltransferases. | 08-16-2012 |
20120240291 | Regulatory regions preferentially expressing in non-pollen plant tissue - Regulatory regions are shown which regulate expression of an operably linked heterologous nucleic acid molecule in plants. Promoters are described which express at lower levels in pollen cells that in other plant cells. Methods of using such promoter to regulate expression of an operably linked nucleic acid molecule are described. A polyadenylation nucleotide sequence from soybean is further shown. | 09-20-2012 |
20120255069 | DNA FRAGMENT FOR IMPROVING TRANSLATION EFFICIENCY, AND RECOMBINANT VECTOR CONTAINING SAME - The present invention relates to a DNA fragment for improving translation efficiency, and a recombinant vector containing the same, and more specifically, to a DNA fragment which comprises any one nucleotide sequence selected from the group consisting of SEQ ID NOs: 1-6, SEQ ID NOs: 8-10, SEQ ID NOs: 13 and 14 and SEQ ID NO: 16, and improves the translation efficiency of a heterologous protein placed in the downstream, and a recombinant vector containing the DNA fragment. The DNA fragment for improving translation efficiency according to the present invention and a recombinant vector containing the same can improve the translation of a heterologous protein in a transgenic plant. In addition, if a leader polynucleotide inducing the targeting to a particular cellular organelle of a plant is further linked to the recombinant vector in an operable manner, the heterologous protein is targeted to the specific cellular organelle and can be stably accumulated, thereby enabling the mass production of the heterologous protein from the plant. | 10-04-2012 |
20130074219 | PROMOTERS AND METHODS THEREOF - A promoter, which may be used to transform a plant and/or express a gene substantially uniformly in substantially all organs and/or tissues of a plant, and which may include a constitutive expression promoter for transforming a monocot plant. A vector including a promoter, which may include a recombinant plant expression vector. A method of producing a target protein using a vector, and a method of producing a transformed cell and/or plant using a vector. A transformed plant, a transformed seed and a transformed cell are included, which may be formed by the method of producing the same using a vector. | 03-21-2013 |
20130091604 | ABOVEGROUND ORGAN SPECIFIC PROMOTERS FOR TRANSFORMING PLANTS AND USES THEREOF - A promoter for transformation of a plant, in particular an aboveground organ specific promoter, a recombinant plant expression vector including the promoter, a method of producing target protein using the recombinant plant expression vector, target protein produced by the method, a method of producing a transformed plant using the recombinant plant expression vector, a transformed plant produced by the same, and a seed of the plant. | 04-11-2013 |
20130139280 | Plants Having Enhanced Yield-Related Traits and a Method for Making the Same - Methods for enhancing various economically important yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a LEJ1 (Loss of timing of ET and JA biosynthesisI) polypeptide, ExbB polypeptide, NMPRT (nicotinamide phosphoribosyltransferase) polypeptide, AP2-26-like polypeptide or HD8-like polypeptide are provided. Plants produced by the methods are also provided, which have enhanced yield-related traits relative to corresponding wild type plants or other control plants. Constructs comprising a nucleic acid encoding a LEJ1, ExbB, NMPRT, AP2-26-like or HD8-like polypeptide and uses thereof are provided. | 05-30-2013 |
20130283482 | STRESS RESISTANT PLANTS - Stress tolerance in plants and plant cells is achieved by using nucleotide sequences encoding enzymes involved in the NAD salvage synthesis pathway and/or the NAD de novo synthesis pathway from fungal or yeast like organisms other than | 10-24-2013 |
20130347144 | PROMOTERS AND METHODS FOR TRANSFORMING TUBERS AND TRANSFORMED TUBERS - The present disclosure relates to a plant promoter and a method of transforming | 12-26-2013 |
20140090108 | Vectors and Methods For Enhancing Recombinant Protein Expression in Plants - Expression vectors and methods of their use for enhancing the production of recombinant proteins in plants or plant cells are described. Production can be further enhanced upon co-expression of the P19 suppressor of gene-silencing from tomato bushy stunt virus. Preferably, the recombinant proteins are therapeutic enzymes and/or antibodies and methods are carried out in | 03-27-2014 |
20140250549 | PROTEIN EXPRESSION SYSTEMS - The invention is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (“CPMV-HT”) based protein expression system. | 09-04-2014 |
20140359902 | EXPRESSION OF SECRETORY IgA ANTIBODIES IN DUCKWEED - Secretory IgA antibodies can be made by expression in a stably-transformed duckweed. | 12-04-2014 |
20150020238 | Plant producing human enterokinase light chain protein and uses thereof - The present invention provides a synthetic gene encoding the human enterokinase light chain protein, a recombinant vector comprising the synthetic gene encoding the protein, a plant cell transformed with the recombinant vector, a method for producing the human enterokinase light chain protein in a plant by using the recombinant vector, a method for producing a plant producing the human enterokinase light chain protein by transforming a plant cell with the recombinant vector, a plant producing the human enterokinase light chain protein which is produced by the method, and a seed thereof, and a composition for large-scale production of the human enterokinase light chain protein in a plant, in which the composition comprises the synthetic gene encoding the human enterokinase light chain protein. | 01-15-2015 |
20150067920 | PLANTS WITH INCREASED STRESS TOLERANCE - Provided herein are plants with increase stress tolerance and methods of making same. | 03-05-2015 |
20150315604 | PRODUCTIONS OF HETERO-OLIGOMERIC PROTEINS IN PLANTS - Process of producing in a plant, in plant tissue, or in plant cells a hetero-oligomeric protein comprising at least a first and a second protein subunit, said process comprising expressing in plant cells at least said first and said second protein subunit by
| 11-05-2015 |
20150376632 | PROMOTERS AND METHODS THEREOF - A promoter, which may be used to transform a plant and/or express a gene substantially uniformly in substantially all organs and/or tissues of a plant, and which may include a constitutive expression promoter for transforming a monocot plant. A vector including a promoter, which may include a recombinant plant expression vector. A method of producing a target protein using a vector, and a method of producing a transformed cell and/or plant using a vector. A transformed plant, a transformed seed and a transformed cell are included, which may be formed by the method of producing the same using a vector. | 12-31-2015 |
20160002654 | NUCLEIC ACID MOLECULE FOR EXPRESSING FOREIGN GENE IN PLANT AND METHOD THEREFOR - A nucleic acid molecule for expressing a foreign gene in a plant, said nucleic acid molecule carrying, in this order, a right border (RB) sequence derived from the T-DNA sequence of an agrobacterium, an expression promoter sequence capable of functioning in the aforesaid plant, a sequence corresponding to the RNA2 genome of cucumber mosaic virus wherein a 2b protein-encoding gene has been partly or entirely substituted by the aforesaid foreign gene, and a left border (LB) sequence derived from the T-DNA sequence of an | 01-07-2016 |
20160017353 | MODIFIED PROMOTER SEQUENCE AND APPLICATION THEREOF - The present invention relates to a modified plant promoter and applications using the same, including an expression construct comprising the promoter for expressing a gene of interest in a plant expression system. In particular, the present invention relates to a method for producing a polypeptide by expressing a plant cell transformed with the expression construct and recovering the polypeptide from the culture. The present invention also relates to a method for producing a polypeptide by growing a transgenic plant transformed with the expression construct and recovering the polypeptide from the transgenic plant. | 01-21-2016 |
20160076048 | NON-GLYCOSYLATED TRANSFERRIN EXPRESSED IN MONOCOTS - Disclosed are compositions and methods of making non-glycosylated transferrin protein in transgenic monocot plants. | 03-17-2016 |
20160115498 | METHODS OF MODULATING N-GLYCOSYLATION SITE OCCUPANCY OF PLANT-PRODUCED GLYCOPROTEINS AND RECOMBINANT GLYCOPROTEINS - A process of producing a recombinant glycoprotein in a plant, in cells of a plant, or in plant cells, comprising expressing in said plant, in cells of said plant or in said plant cells a nucleic acid sequence encoding a polypeptide, said polypeptide having an N-glycosylation site of consensus sequence Asn-X-Ser or Asn-X-Thr, X being any standard amino acid residue, wherein, if the Asn residue of said N-glycosylation site is assigned amino acid sequence position 0,
| 04-28-2016 |
20160138036 | METHOD FOR INACTIVATING TARGET TRANSCRIPTION FACTOR USING ARTIFICIAL SMALL INTERFERING PEPTIDE AND USE THEREOF - The present invention relates to a method for targeted inactivation of transcription factor using an artificial small interfering peptide and a use thereof. According to the present invention, an artificial small interfering peptide (a-siPEP) as a truncated from of the transcription factor for regulating transcription by dimerization was produced. It was also confirmed that, as a-siPEP forms a heterodimer with a transcription factor, DNA binding and transport into a nucleus of the transcription factor are inhibited, so that inactivation of the transcription factor is achieved at protein level. The method for inhibiting transcription factor activity using a-siPEP can replace a gene knock-out method and it allows protein-level inhibition of a transcription factor. Also, it is a transcription regulation method with high precision and high efficiency that can be applied for both monocot and dicot plants. | 05-19-2016 |
20160160228 | TRANSGENIC ALOE PLANTS FOR PRODUCTION OF PROTEINS AND RELATED METHODS - The present inventions provide transgenic aloe plants and recombinant constructs for transforming aloe plants, aspects of which, may be applied to other monocots. The recombinant constructs may include one or more DNA sequences encoding mammalian proteins and at least one promoter capable of directing the expression of recombinant proteins in an aloe plant. The present inventions also provide methods for constructing and reproducing a transgenic aloe plant. The present inventions include methods for transfection of an aloe plant with several genes of interest simultaneously. The aloe plant production methods of the inventions may provide the potential to inexpensively and more safely mass-produce some biologically active compounds including biopharmaceuticals for disease therapy, diagnosis and prevention, and is more accessible to the less affluent countries. The aloe plant production methods may also produce proteins for cosmetics. | 06-09-2016 |