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NONHUMAN ANIMAL

Subclass of:

800 - Multicellular living organisms and unmodified parts thereof and related processes

Patent class list (only not empty are listed)

Deeper subclasses:

Class / Patent application numberDescriptionNumber of patent applications / Date published
800013000 Transgenic nonhuman animal (e.g., mollusks, etc.) 605
800009000 The nonhuman animal is a model for human disease 166
Entries
DocumentTitleDate
20110191868METHODS FOR IDENTIFICATION AND USE OF AGENTS TARGETING CANCER STEM CELLS - The invention relates to methods for identifying compounds and compositions that target cancer stem cells. In some aspects, the invention relates to treatment methods that use compounds and compositions that specifically target cancer stem cells for inhibiting the growth and/or survival of cancer stem cells in a subject in need thereof. Other aspects of the invention relate to the use of cancer stem cell biomarkers in the selection of a treatment for inhibiting the growth and/or survival of cancer stem cells in a subject in need thereof.08-04-2011
20110191867PEPTIDE VACCINE FOR INFLUENZA VIRUS - The invention provides peptide epitopes for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza. The invention also relates to a method for evaluating the potential of a chemical entity, such as an antibody, to bind to a peptide epitope derived from the divalent sialoside binding site of hemagglutinin protein of influenza virus, and to conjugates containing one or more such peptide epitopes. The peptide epitopes of the invention are cyclic peptides comprising a 7-mer peptide derived from H1, H3 or H5 hemagglutinin of influenza virus. The 7-mer peptide has a sequence corresponding to the loop sequence at positions 220-226 of X31-hemagglutinin.08-04-2011
20110197289Storage of Entomopathogenic Nematodes - This invention relates to methods of prolonged storage of the species of entomopathogenic nematodes belonging to the genera of 08-11-2011
20120180147MICRORNA-24 - The present invention relates to a modulator, in particular an inhibitor, of microRNA-24 (miR-24) and to direct and indirect miR-24 targets for use in a method of treatment and/or prevention of ischemia, in a method of prevention of endothelial apoptosis or in a method of induction of angiogenesis. The present invention further relates to a precursor of miR-24 and to siRNAs or shRNAs against direct or indirect miR-24 targets for use in a method of treatment of angiogenesis associated with cancer. The present invention also relates to an in vitro method for diagnosing ischemia or prevalence or disposition for ischemia, and to a method for identifying a modulator of miR-24 and/or direct or indirect miR-24 targets. In addition, the present invention relates to pharmaceutical compositions or kits comprising any of the above agents, to endothelial cells devoid of expressing functional miR-24, and to a non-human, transgenic animal comprising these endothelial cells.07-12-2012
20100115638METHOD FOR INHIBITING THE EXPRESSION OF ENDOGENOUS ERYTHROPOIETIN (EPO) - The present invention concerns a method for functional inactivation of endogenous erythropoietin (EPO) in a subject comprising the step of (a) co-administrating to said subject at least one agent and at least one erythropoietin protein or derivative, or at least one nucleic acid sequence encoding said erythropoietin protein or derivative, said agent being administrated simultaneously, sequentially or separately with said erythropoietin protein or derivative, or nucleic acid sequence encoding said erythropoietin protein or derivative, wherein said at least one agent and at least one erythropoietin protein or derivative, or at least one nucleic acid sequence encoding said erythropoietin protein or derivative are administrated in an effective amount for triggering the production of neutralizing antibodies against the endogenous erythropoietin (EPO) in said subject; a non human vertebrate which can be obtained by said method and a neutralizing antibody directed against erythropoietin isolated from said subject.05-06-2010
20130086702Replication of Undifferentiated Cells in a Weightless Environment, Uses Thereof and a Facility for Such Replication and The Acceleration of the Evolution of Plants and Animals - The present invention provides manufacturing processes for biological replication of undifferentiated plant and animal cells and tissue in a weightless condition, including those systems used in current stem cell research and development and use of undifferentiated parenchyma in plants. The present invention further provides methods for adapting plants and animals to survive outside their native environments. In particular, undifferentiated cells from plants or animals are replicated under weightless conditions in which cell replication or proliferation is accelerated and sustained. Under such conditions, the undifferentiated cells can be “forced” to express sets of genes useful for survival in particular environmental conditions. In this manner, cells surviving prolonged exposure to specific environmental conditions can be selected for and cultivated to produce an organism adapted to that particular environment in an accelerated manner. Methods of identifying specific genes associated with adaptation of a plant or animal to a specific environment are also disclosed.04-04-2013
20120210452ALKOXYLATED NON-IONIC ALKANOL ADJUVANT FORMULATIONS AND METHODS FOR MAKING AND USING THE SAME - Embodiments include adjuvant formulations containing an alkoxylated alkanol adjuvant having the following alkanol structure:08-16-2012
20100024048METHOD FOR MITE PRODUCTION - A method for culturing and producing mites, such as house dust mites, comprising culturing the mites in a suitable solid growth medium, under suitable conditions and for a suitable period of time in a suitable production room, characterized in that the mites are cultured in medium comprised within a closed bag.01-28-2010
20100095388Erythropoietin-Producing Organoid Precursor, Production Method Thereof, and Method For Treating Erythropoietin-Related Disorder - The subject of the present invention is to provide a means to producing an erythropoietin-producing organoid using mesenchymal stem cell derived from a mammal. It is a method for producing erythropoietin-producing organoid (organ-like structure) precursor, comprising the step of transplanting mesenchymal stem cell derived from a mammal into an embryo within a pregnant mammalian host or an embryo separated from a pregnant mammalian host to thereby induce the differentiation of the mesenchymal stem cell, in particular, a site to which the mesenchymal stem cell is to be transplanted is a nephrogenic site of the embryo, and a timing of transplantation corresponds to the stage in which a immune system of the host is still immunologically tolerant.04-15-2010
20090094706LABORATORY-SELECTED COLONIES OF WESTERN CORN ROOTWORM WITH INCREASED TOLERANCE TO MAIZE CONTAINING EVENT DAS-59122-7 AND METHODS OF USE - Laboratory-selected colonies of western corn rootworm exhibiting tolerance to maize containing event DAS-59122-7 are described. Further, methods for various uses of these resistance western corn rootworm colonies are also described, including development of negative cross-resistance strategies and improved resistance management strategies.04-09-2009
20090094705LABORATORY-SELECTED COLONIES OF WESTERN CORN ROOTWORM WITH INCREASED TOLERANCE TO MAIZE CONTAINING EVENT DAS-59122-7 - Laboratory-selected colonies of western corn rootworm exhibiting tolerance to maize containing event DAS-59122-7 are described. Further, methods for various uses of these resistance western corn rootworm colonies are also described, including development of negative cross-resistance strategies and improved resistance management strategies.04-09-2009
20080263686ANIMAL MODEL FOR PIGMENT SPOTS - An animal model for pigment spots in which the formation of pigment spots in human skin is faithfully simulated is provided. An animal model for pigment spots, wherein a black person's skin is grafted onto a non-human animal, is provided.10-23-2008
20120227119Methods of Modulating the Sex of Avians - The present invention relates to nucleic acids and methods for modulating the sex of avians. In particular, the invention relates to the in ovo delivery of a dsRNA molecule, especially siRNAs, to increase the production of female birds.09-06-2012
20130067606MODULATING PRODUCTION TRAITS IN AVIANS - The present invention relates to methods of modulating traits, particularly production traits, in avians such as chickens. In particular, the invention relates to the in ovo delivery of a dsRNA molecule, especially siRNAs, to modify production traits in commercially important birds.03-14-2013
20120131688Reverse Breeding - A method for efficiently producing homozygous organisms from a heterozygous non-human starting organism, comprising providing of a heterozygous starting organism; allowing the starting organism to produce haploid cells; creating homozygous organisms from the haploid cells thus obtained; and selecting the organisms having the desired set of chromosomes, wherein during production of the haploid cells no recombination occurs in order to obtain a limited number of genetically different haploid cells. Recombination can also be prevented or suppressed.05-24-2012
20110302665NON-HUMAN MAMMALS WITH T OR B CELLS HAVING PREDEFINED SPECIFICITY - The present invention provides non-human mammals, e.g., mice, generated from a T cell or B cell with a predefined specificity or isolated from an organism suffering from a condition of interest. In some embodiments the non-human mammals are not genetically modified. Also provided are methods of using the non-human animals.12-08-2011
20110289606EQUINE DISEASE MODEL FOR HERPESVIRUS NEUROLOGIC DISEASE AND USES THEREOF - Disclosed is an in vivo equine disease model and a method of preparing the disease model for equine herpesvirus-1 neurological disease comprising a horse having a low pre-exposure level of herpesvirus-specific CTL precursors wherein the horse is experimentally infected with a neuropathogenic strain of equine herpesvirus or a mutant thereof. Also disclosed is a method of quantifying the risk factors and predicting the development of clinical neurologic signs of equine herpesvirus-1 neurological disease in a horse. Also described in the invention is the determination of the risk of developing the clinical neurologic signs by a mathematical equation. A new live, attenuated vaccine formulation is disclosed that is effective against neurologic disease due to equine herpesvirus-1.11-24-2011
20110289607METHOD OF INHIBITING GENE EXPRESSION - The present invention relates to a method for inhibiting expression of a target gene, which comprises introducing a cell, tissue, or individual organism with a double-stranded polynucleotide comprising DNA and RNA having a substantially identical nucleotide sequence with at least a partial nucleotide sequence of the target gene.11-24-2011
20110296542EXOGENOUS MATRIX-SUPPORTED TOPICAL APPLICATION OF STEM CELLS TO ORGAN SURFACE - A process of tissue regeneration is provided that includes the administration of a stem cell topically to a surface of a tissue. The tissue being in vivo in a subject or in vitro. The tissue has a biocompatible matrix applied around the stem cell and in contact with the surface. After sufficient time, the stem cell infiltrates and regenerates the tissue. A composition is also provided that includes an injured or diseased tissue with a plurality of stem cells proximal to the tissue surface in a biocompatible. A process of increasing a level of cytokines, chemokines, growth factors, anti-apoptotic or anti-necrotic factors in a tissue is provided that includes the administration of a stem cell topically to a surface of a tissue in a biocompatible matrix. After sufficient time, the stem cell releases soluble pro-regenerative factors to increase the levels in the tissue.12-01-2011
20100269181Method for Identifying and Managing Livestock by Genotype - The present invention provides for a direct correlation between the rate of a feed conversion in livestock animals and the presence of alleles of a gene encoding an adipocyte-specific polypeptide, termed leptin, which gene is hereinafter referred to as ob. The invention also provides novel compositions consisting essentially of specific oligonucleotides that are useful as primers to amplify particular regions of the genome during enzymatic nucleic acid amplification, thus providing a rapid, sensitive and specific method for the detection of the ob-gene polymorphism which may be present in a specimen. The invention further provides for methods of screening bovine to determine those having predictably more uniform fat deposition and advantageously selecting those livestock for future breeding and management purposes based on the ob polymorphisms.10-21-2010
20090188000GENE FAMILY (LBFL313) ASSOCIATED WITH PANCREATIC CANCER - The invention relates generally to the changes in gene expression in human pancreatic adenocarcinoma. The invention relates specifically to a human gene family which is differentially expressed in cancerous pancreatic tissues compared to corresponding non-cancerous pancreatic tissues.07-23-2009
20090126033Method of selective breeding based on ob genotype - A method for improving efficiencies in livestock production comprises grouping livestock animals, such as cattle and pigs, during the period of their retention in a feeding facility according to the genetic predisposition of individual livestock animals to deposit fat, and then feeding the animals in each group substantially uniformly. Such genetic predisposition is determined by determining homozygosity or heterozygosity of each animal with respect to alleles of a gene encoding an adipocyte-specific polypeptide, termed leptin, which gene is hereinafter referred to as ob, segregating such animals into groups based on genotype and optionally phenotype, feeding and otherwise maintaining animals in a group together and apart from other groups of animals, and ceasing to feed the animals in the group at a time when the median body fat condition of the animals of that group is a desired body fat condition. Packers can also more accurately predict the fat deposition in carcasses of live animals it purchases, leading to increased efficiencies.05-14-2009
20120110683NON-HUMAN ANIMAL MODEL OF MYOCARDIAL INFARCTION AND METHOD FOR CREATING THE SAME - The present invention provides a non-human animal model of myocardial infarction, which can be created by a less invasive method, shows an extremely low mortality during and after surgical induction of myocardial infarction, ensures the blood reflow after necrosis of cardiac muscles caused by blocking blood flow, and therefore, is usable in topical therapy for myocardial infarction and studies on regenerative medicine. The present invention also provides a method for creating the non-human animal model comprising administering a temporary embolic agent to a branch blood vessel of a heart coronary artery to block blood flow in the branch blood vessel; and after a definite period of time after said vascular branch blockage, administering a temporary embolic agent to the target coronary artery which is intended to induce myocardial infarction to block blood flow in the target coronary artery.05-03-2012
20120036589VACCINE - The present invention is concerned with the development of a vaccine against 02-09-2012
20100122360Organ regeneration method utilizing blastocyst complementation - An object of the present invention is to produce a mammalian organ having a complicated cellular composition composed of multiple kinds of cells, such as kidney, pancreas, thymus and hair, in the living body of a non-human animal. The inventors of the present invention applied the chimeric animal assay described above, to a novel solid organ production method. More specifically, the inventors has shown that a model mouse which is deficient of kidney, pancreas, thymus or hair due to the dysfunction of the metanephric mesenchyme that is differentiated into most of an adult kidney, is rescued by blastocyst complementation by the chimeric animal assay, and whereby a kidney, a pancreas, thymus or hair can be newly produced.05-13-2010
20120297493Gene Therapy Using Transposon-Based Vectors - Methods and compositions are presented for the administration of transposon-based vectors to an animal or human to provide gene therapy to the animal or human.11-22-2012
20090288179Inactivated Nodavirus Vaccine - A vaccine against nodavirus infection in fish can be produced by inactivating the virus using an aziridine compound. This vaccine can be used to prevent Viral Nervous Necrosis (VNN) in a variety of fish species.11-19-2009
20100083390FORMULATION FOR THE BIOLOGICAL CONTROL OF INSECT-PESTS - A formulation for the biological control of pests comprises a cohort of infective juvenile insect-parasitic nematodes from at least three species, wherein at least two of the species are of a first genus, and at least one of the species is from a second genus, and the species number from the first genus is greater than the species number from the second genus. The cohort of nematodes consists essentially of two species from the first genus and one species from the second genus and comprises at least one ambusher foraging species of nematode from a first genera and at least two cruiser foraging species of nematode from a different genera, or at least two ambusher foraging species of nematode from the same genera and at least one cruiser foraging species of nematode from a different genera. The first and second genus are selected from the group comprising: Steinernematidae and Heterorhapditidae.04-01-2010
20090328242Replication of Undifferentiated Cells in a Weightless Environment, Uses Thereof and a Facility for Such Replication and the Acceleration of the Evolution of Plants and Animals - The present invention provides manufacturing processes for biological replication of undifferentiated plant and animal cells and tissue in a weightless condition, including those systems used in current stem cell research and development and use of undifferentiated parenchyma in plants. The present invention further provides methods for adapting plants and animals to survive outside their native environments. In particular, undifferentiated cells from plants or animals are replicated under weightless conditions in which cell replication or proliferation is accelerated and sustained. Under such conditions, the undifferentiated cells can be “forced” to express sets of genes useful for survival in particular environmental conditions. In this manner, cells surviving prolonged exposure to specific environmental conditions can be selected for and cultivated to produce an organism adapted to that particular environment in an accelerated manner. Methods of identifying specific genes associated with adaptation of a plant or animal to a specific environment are also disclosed.12-31-2009
20110145938METHOD FOR GENERATING MONOCLONAL ANTIBODIES THAT RECOGNIZE PROGENITOR CELLS - Method for generating monoclonal antibodies that recognize progenitor cells. Said method comprises immunization of an Armenian hamster with neurospheres obtained from olfactory bulb cells from a 13.5-day mouse embryo and subsequent selection of the antibodies by means of neurosphere flow cytometry in the presence of propidium iodide. The antibodies thus obtained may be of use in the enrichment of cell cultures in progenitor cells, primarily neural progenitor cells.06-16-2011
20090249502NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 193P1E1B USEFUL IN TREATMENT AND DETECTION OF CANCER - A novel gene (designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 193P1E1B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P1E1B can be used in active or passive immunization.10-01-2009
20080307535 DAIRY CATTLE BREEDING FOR IMPROVED MILK PRODUCTION TRAITS IN CATTLE - Nucleic acid molecules comprising a SNP site at position 1296 of bovine uterine milk protein (UTMP) coding sequence (SEQ ID NO: 1), which SNP indicates a desirable productive life in a dairy cattle. Also disclosed are an array or a kit comprising the same, a method for detecting the SNPs, a method for progeny testing of cattle, and a method for selectively breeding of cattle.12-11-2008
20120246746Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Techniques - This invention relates to methods for making immune compatible tissues and cells for the purpose of transplantation and tissue engineering, using the techniques of nuclear transfer and cloning. Also encompassed are methods for determining the effect on immune compatibility of expressed transgenes and other genetic manipulations of the engineered cells and tissues.09-27-2012
20100212032Compositions and Methods for the Efficient and Reproducible Generation of Clone Animals of All Developmental Stages and Methods of Use Thereof - Compositions and methods are provided for the efficient and reproducible generation of clone animals of all developmental stages. Also provided are methods of use of the same in reproductive and therapeutic cloning protocols.08-19-2010
20100146648Immunosuppression by blocking T cell co-stimulation signal 2 (B7/CD28 interaction) - The invention provides means and methods for inhibiting T-cell mediated rejection of a xenotransplanted organ by blocking the delivery of co-stimulatory signal 2 (the B7/CD28 interaction) in order to prevent the activation of xenoreactive T-cells in the recipient. In a first aspect, co-stimulation is prevented by administration to the organ recipient of a soluble form of CTLA-4 from the xenogeneic donor organism. This preferentially binds B7 on the xenograft and blocks the interaction between B7 on the xenogeneic donor cells and CD28 on recipient T-cells. In a second aspect, co-stimulation is antagonised by expressing a ligand for CTLA-4 on the xenogeneic donor cells. This ligand binds to CTLA-4 on activated T-cells of the recipient and antagonises signal 2. In a third aspect, co-stimulation is prevented by expressing recipient organism MHC class II on the surface of the cells of the xenogeneic donor organ. The donor cells are thus able to present xenoantigens to a recipient T-cell in the context of self-MHC class II. If the donor cells do not express B7, or if B7 is blocked, the xenoreactive recipient T-cell becomes anergic.06-10-2010
20100235930METHODS OF SELECTING HOST RESISTANT ANIMALS - The present invention is directed to a method of selecting animals that are genetically resistant to one or more intestinal parasite infections by testing mucus samples for the presence of an antibody against one or more of said intestinal parasites and segregation and selecting the animals that test positive. The animals that test negative are less parasite resistant and can be subjected to parasite management regimes.09-16-2010
20100212031Method for improving efficiencies in livestock production - A method for improving efficiencies in livestock production comprises grouping livestock animals, such as cattle and pigs, during the period of their retention in a feeding facility according to the genetic predisposition of individual livestock animals to deposit fat, and then feeding the animals in each group substantially uniformly. Such genetic predisposition is determined by determining homozygosity or heterozygosity of each animal with respect to alleles of a gene encoding an adipocyte-specific polypeptide, termed leptin, which gene is hereinafter referred to as ob, segregating such animals into groups based on genotype and optionally phenotype, feeding and otherwise maintaining animals in a group together and apart from other groups of animals, and ceasing to feed the animals in the group at a time when the median body fat condition of the animals of that group is a desired body fat condition. Packers can also more accurately predict the fat deposition in carcasses of live animals it purchases, leading to increased efficiencies.08-19-2010
20100122359Sex Selected Equine Intracytoplasmic Sperm Injection Embryo Production System - Intracytoplasmic sperm injection utilizing sex-selected equine spermatozoa to obtain viable sex selected embryos transferable to a recipient female equine mammal to obtain sex selected foals.05-13-2010
20120144508ARTIFICIAL SELECTION METHOD AND REAGENTS - The present invention provides methods for estimating the breeding value of individuals in populations such as those having small effective population size (Ne) e.g., to identify selection candidates having high breeding values, wherein the methods comprise inferring one or more genotypes for one or more markers at a locus or QTL to be the same as for an ancestor or founder or a subset of ancestors and/or founders from which a corresponding chromosome segment is derived and estimating the breeding value of the individual based on the inferred genotype(s).06-07-2012
20130139274B-CELL STIMULATING FUSION PROTEINS OF AN ANTIGEN WITH BAFF OR APRIL - The invention relates to the fields of molecular biology, medicine, virology and vaccine development. Because the different forms of the presently available vaccines all have their specific drawbacks, there is a need for alternative vaccine strategies. The current invention provides means and methods for such alternative vaccine strategies.05-30-2013
20100192236Modulation of Delta Opioid Receptor Expression - In accordance with certain embodiments of the present disclosure, an expression cassette is provided. The expression cassette includes a heterologous nucleotide sequence that encodes a delta opioid receptor.07-29-2010
20110119774COMPOSITIONS OF AQUATIC ORIGIN FOR PREVENTION OF CELL ADHESION AND METHODS OF USING SAME - A composition comprising an extract from an aquatic organism is disclosed. The composition is capable of preventing adhesion of a cell to a surface and is devoid of cytotoxic or cytostatic activity. Medical devices comprising same and methods for preventing or treating a pathological infection using same are also disclosed.05-19-2011
20110126300High Through-Put Method of Screening Compounds for Pharmacological Activity - Provided is a method for high through-put screening for physiologic alterations in an altered teleost displaying a phenotype that is characteristic of the alteration and different from a wild-type, unaltered, matched teleost, comprising the steps of contacting the teleost displaying a genetically-inherited or chemically-induced phenotype with at least one test compound for a sufficient time and under suitable conditions to induce a response in the teleost indicative of pharmacological activity of the compound, and detecting and comparing the response with that of a matched, untreated, control, wherein a change in the teleost signal that is different from that of the control, indicates an altered phenotype and pharmacological activity of the at least one test compound. Further provided are the compounds identified by this method, the zebrafish having an altered phenotype resulting from treatment in accordance with these methods, and kits for facilitating the high through-put screening methods.05-26-2011
20090217393Growth Promoting Agent and Life Prolonging Agent - An object of the present invention is to provide a growth promoting agent and a life prolonging agent which are safer than a conventional one, and can be used for stable and effective production of animals including farm animals, domestic fowls and fishes/shellfishes, stable and effective cultivation of plants including vegetables, fruits and grains, stable and effective culture of microorganisms, and stable and effective cultivation of mushrooms. The present invention provides the growth promoting agent comprising a sugar alcohol, particularly erythritol, as an active ingredient and a life prolonging agent comprising a sugar alcohol, particularly erythritol, as an active ingredient.08-27-2009
20110078803Sex selected equine embryo production system - A sex selected equine embryo production system for the production of sex selected equine embryos and offspring by fertilization of oocytes with sex selected sperm by intracytoplasmic sperm injection.03-31-2011
20110252486CHONDROCYTE-LIKE CELL, AND METHOD FOR PRODUCING SAME - Disclosed is a cell which enables the reproduction of a cartilage tissue and has a proliferative ability. Also disclosed is a technique for providing a cell supply source which can be used in a definitive treatment of osteochondrosis deformans. A chondrocyte-like cell which has the same properties as those of a chondrocyte and can proliferate can be produced by selecting a combination of an Myc family gene and/or a Klf family gene and a SOX9 gene and introducing the combination into a somatic cell. The chondrocyte-like cell can be used for a medical purpose of cartilage regeneration.10-13-2011
20110258711METHOD FOR DIAGNOSTIC MARKER DEVELOPMENT - The invention relates to a method for the generation of unique molecular markers in existing breeding material by selecting a marker associated with a trait, identifying the existing variation at the nucleotide level within a set of markers within a germplasm and introducing a selectable marker by the introduction of one or more nucleotides at positions in a constant region of the marker by targeted nucleotide exchange.10-20-2011
20110010782ADAPTING PARASITES TO COMBAT DISEASE - Provided are systems and/or methods that facilitate sensing, detecting, logging, or treatment of a condition or need of a living body using a controlled parasite.01-13-2011
20110154514Polynucleotide used for releasing recombinant protein to the outside of eukaryotic cell - This invention provides a method for efficiently producing a recombinant protein by allowing the recombinant protein to express in a eukaryotic cell and releasing the expressed recombinant protein to the outside of the cell. The invention provides a polynucleotide used for producing a recombinant protein in a host cell comprising a polynucleotide encoding a glycosylation sequence comprising a transitional endoplasmic reticulum signal sequence and the sequence represented by: Asn-X-(Thr/Ser) (wherein X is an amino acid other than proline) and a polynucleotide encoding a target protein, which would not be efficiently released to the outside of the cell even when a transitional endoplasmic reticulum signal sequence is fused. The polynucleotide releases the target protein to the outside of the host cell via sugar chain modification.06-23-2011
20110179504Method For Coral Tissue Cultivation And Propagation - This invention relates to a novel method of culturing coral tissues and polyps in vitro. Coral tissues obtained by the method of the invention may be maintained as heterotypic spheroid tissue balls for a period of at least three months or they may be induced to undergo development into new polyps, a process termed re-morphogenesis. This method can produce genetic clones of model species from single individuals that can be propagated either as undifferentiated tissue calli or as developed polyps. The products of the invention are of value to a number of educational, scientific, and commercial endeavors. Specifically, this method can be used to propagate genetic clones (strains) of a model organism for scientific research, to serve as ‘pro-environmental conservation’ sources of coral stock for educational specimens as well as a rapidly generated inventory for commercial aquarium industry. The method of the invention can produce sustainable test lines of corals that could be used to generate risk assessments for the impact of chemicals/activities on coral reefs, as well as being used as part of a regulatory protocol for testing waste effluent and other discharges.07-21-2011
20090205057MITE COMPOSITION COMPRISING GLYCYPHAGIDAE AND PHYTOSEIID MITES, USE THEREOF, METHOD FOR REARING A PHYTOSEIID PREDATORY MITE, REARING SYSTEM FOR REARING SAID PHYTOSEIID PREDATORY MITE AND METHODS FOR BIOLOGICAL PEST CONTROL ON A CROP - The present invention relates to a novel mite composition comprising a population of a phytoseiid predatory mite species and a factitious host population comprising a species selected from the Glycyphagidae, which may be employed for rearing said phytoseiid predatory mite species or for releasing the phytoseiid predatory mite species in a crop. According to further aspects the invention relates to a method for rearing a phytoseiid predatory mite species, to the use of the mite composition and to a method for biological pest control in a crop, which employ the mite composition.08-13-2009
20090126032Method to produce cloned embryos and adults from cultured cells - A nuclear transfer method is provided wherein nuclear DNA in whole or part is injected into enucleated oocytes. The method is suitable for different donor cells, and preferably ES cells.05-14-2009
20080250511Preprotachykinin Enhancer Elements - Provided are previously uncharacterised enhancer elements from the preprotachykinin-A (PPTA) which shows transcriptional enhancement activity in Substance P (SP) expressing cells. These are termed ECR1 and ECR2. The invention provides nucleic acids comprising these sequences and variants or fragments thereof, plus methods and materials based thereon, such as transformed host cells, transgenic animals, and screening and expression systems.10-09-2008
20110265193IDENTIFICATION OF MUTATION AND METHOD FOR DETECTING LAVENDER FOAL SYNDROME IN THE HORSE - Provided is a method for determining whether a horse is normal, a carrier, or is affected with Lavender Foal Syndrome (LFS). The method entails, in a biological sample obtained or derived from a horse, determining a single nucleotide deletion which introduces a translational stop codon in the 4910-27-2011
20110191869Method For Characterising The Biological Activity Of Helminth Eggs, In Particular Trichuris Eggs - A method for determining the biological activity of embryonated 08-04-2011
20100017899METHOD FOR THE ISOLATION OF PLURIPOTENT CELLS FROM A PRE-IMPLANTATION EMBRYO IN A CULTURE MEDIUM FREE FROM ANIMAL SERUM - The present invention provides a method of isolating a pluripotent cell from a pre-implantation embryo without isolation of the pluripotent cells from other cells, the method including propagating a whole pre-implantation embryo including one or more pluripotent cells, embedded in a feeder cell layer and cultivated in a medium substantially free of serum, and isolating a pluripotent cell from the one or more pluripotent cells. The present invention also provides pluripotent cells generated by the method and uses thereof.01-21-2010
20110307965METHODS AND COMPOSITIONS FOR DETECTING CANINE DILATED CARDIOMYOPATHY (DCM) - This invention provides the identification of a 16 base pair deletion in a splice site region between exons 10 and 11 of the dog PDK4 gene that is linked to dilated cardiomyopathy (DCM). Also provided are methods for detecting DCM and methods of breeding dogs to reduce the prevalence of DCM.12-15-2011
20110307964MOUSE HAVING HUMAN LEUKEMIC STEM CELL AND LEUKEMIC NON-STEM CELL AMPLIFIED THEREIN, AND METHOD FOR PRODUCTION THEREOF - The invention relates to a method of selectively expanding human leukemic cells in a non-adult NOD/SCID/IL2rg12-15-2011
20120066778CONTROL OF URIC ACID HOMEOSTASIS - The invention relates to vectors and mammalian cells in a system useful for switching on or switching off gene expression in response to uric acid. In a particular embodiment the invention relates to a mammalian cell useful in detecting and/or degrading a harmful excess of uric acid comprising (a) a vector comprising a genetic code for the uricase sensor-regulator HucR from 03-15-2012
20120047587ESTROUS CYCLE MONITORING BY COLOR RESPONSE - A method of determining the phase of an estrous cycle that a mammal is in at a given time that a biological sample is obtained from the mammal is provided. The biological sample obtained from the mammal is combined with at least one flavonoid pigment that reacts with the biological sample on a hydrophobic surface to provide a color response. The estrus phase of the estrous cycle has a corresponding color response that is distinguishable from the color response of each other phase of the estrous cycle to an unaided human eye. The corresponding color response is correlated to the estrus phase of the estrous cycle.02-23-2012
20120210451ISLET CELL SHEET, PROCESS FOR PRODUCTION THEREOF, AND USE THEREOF - A polymer that changes hydration at a temperature between 0 to 80° C. is coated on the surface of a cell culture support, and islet cells are cultured on the support at a temperature range that causes polymer to have weak hydration, then the temperature of a culture solution is changed to a temperature that causes the polymer to have strong hydration to obtain islet cells in a sheet form. Such islet cells in a sheet form have an insulin producing function even if there is no blood flow.08-16-2012
20120060229Method For Characterising The Biological Activity Of Helminth Eggs, In Particular Trichuris Eggs - A method for determining the biological activity of embryonated 03-08-2012
20120159657Compositions and Methods for Inhibiting Expression of RRM2 Genes - The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.06-21-2012
20110107441ANIMALS WITH REDUCED BODY FAT AND INCREASED BONE DENSITY - Methods for identifying animals as having reduced body fat and increased bone density are provided herein. Also provided herein are methods for generating animals having reduced body fat and increased bone density. The methods provided herein are based on the effect of TLR4, MD-2, and CD14 activity on body fat and bone density.05-05-2011
20100095389METHODS OF MAINTAINING GENETIC STABILITY OF INBRED ANIMAL STRAINS - The present invention provides novel methods of maintaining genetic stability of non-human animal inbred strains. In the methods, pedigree-tracked cryopreserved embryos derived from a foundation colony are produced and used to re-establish the foundation colony at appropriate intervals.04-15-2010
20120255042METHOD OF REGULATING GENE EXPRESSION - The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.10-04-2012
20120137379NOVEL AAV'S AND USES THEREOF - The invention in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the invention relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.05-31-2012
20120180146Methods for maintaining genetic stability of inbred animal strains - The present invention provides novel methods of maintaining genetic stability of non-human animal inbred strains. In the methods, pedigree-tracked cryopreserved embryos derived from a foundation colony are produced and used to re-establish the foundation colony at appropriate intervals.07-12-2012
20090019557FGF2-RELATED METHODS FOR DIAGNOSING AND TREATING DEPRESSION - The present application relates to the treatment and diagnosis of mood disorders, including bipolar disorder, major depression disorder and schizophrenia. The invention provides novel diagnostic markers and assays, as well as research tools for the development and discovery of agents and compounds which are useful for treating patients who suffer from mental illness.01-15-2009
20110131668IMPROVED GENE SILENCING METHODS - Provided are methods and means to obtain improved gene silencing of target nucleic acids whereby at least two inhibitory RNA molecules are provided which are targeted to the same nucleic acid, but which are processed into short interfering RNA molecules through different processing pathways. Also provided are methods and means to obtain improved gene silencing of target nucleic acids whereby at least two inhibitory RNA molecules are provided which are targeted to different nucleic acids, but which are processed into short interfering RNA molecules through different processing pathways.06-02-2011
20120090040COMPOSITIONS, METHODS, AND SYSTEMS FOR INFERRING BOVINE BREED - Provided herein are methods to discover and use single nucleotide polymorphisms (SNP) for identifying breed, or line and breed, or line composition of a bovine subject. The present invention further provides specific nucleic acid sequences, SNPs, and SNP patterns that can be used for identifying breed or breed combinations for Angus, Holstein, Limousin, Brahman, Hereford, Simmental, Gelbvieh, Charolais and Beefmaster breeds. These patterns can be utilized to manage animals in a feedlot to obtain optimum performance based on known characteristics of specific breeds and identify animals for breeding in selection programs. In another aspect, these patterns can be used to ensure labeling on breed specific branded products.04-12-2012
20130019325Light-Sensitive Ion-Passing Molecules - Disclosed are polynucleotides and methods for expressing light activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The disclosure also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.01-17-2013
20130174287HIGH TROUGHPUT MULTIWELL SYSTEM FOR CULTURING 3D TISSUE CONSTRUCTS IN-VITRO OR IN-VIVO, METHOD FOR PRODUCING SAID MULTIWELL SYTEM AND METHODS FOR PREPARING 3D TISSUE CONSTRUCTS FROM CELLS USING SAID MULTIWELL SYSTEM - The invention relates to a multiwell system, characterized that said multiwell system having at least 3 wells, wherein said wells have a volume between 0.125 and 4.0 mm07-04-2013
20080222740Polypeptides Having Phytase Activity And Polynucleotides Encoding Same - The present invention relates to polypeptides having phytase activity. These polypeptides have an amino acid sequence which has at least 70% identity to either of three phytases derived from the bacterium 09-11-2008
20130174286In Vivo Gene Silencing By Chemically Modified and Stable siRNA - The present invention provides compositions for RNA interference and methods of use thereof. In particular, the invention provides small interfering RNAs (siRNAs) having modification that enhance the stability of the siRNA without a concomitant loss in the ability of the siRNA to participate in RNA interference (RNAi). The invention also provides siRNAs having modification that increase targeting efficiency. Modifications include chemical crosslinking between the two complementary strands of an siRNA and chemical modification of a 3′ terminus of a strand of an siRNA. Preferred modifications are internal modifications, for example, sugar modification, nucleobase modification and/or backbone modifications. Such modifications are also useful, e.g., to improve uptake of the siRNA by a cell. Functional and genomic and proteomic methods are featured. Therapeutic methods are also featured.07-04-2013
20110277042Mite Composition, Use Thereof, Method for Rearing a Phytoseiid Predatory Mite, Rearing System for Rearing Said Phytoseiid Predatory Mite and Methods for Biological Pest Control on a Crop - The present invention relates to a novel mite composition comprising a population of a phytoseiid predatory mite species and a factitious host population, which may be employed for rearing said phytoseiid predatory mite species or for releasing the phytoseiid predatory mite species in a crop. According to further aspects the invention relates to a method for rearing a phytoseiid predatory mite species, to the use of the mite composition and to a method for biological pest control in a crop, which employ the mite composition.11-10-2011
20080201789VARIANTS AND EXONS OF THE GLYT1 TRANSPORTER - The present invention provides polypeptide and polynucleotide sequences for novel splice variants of the sodium and chloride-dependent glycine transporter type 1 (GlyT1). These polypeptides and polynucleotides are useful in the treatment and diagnosis of disorders such as neurological and psychiatric disorders including schizophrenia. The invention also provides antibodies directed specifically against these novel polypeptides, and kits comprising the herein-described polynucleotides, polypeptides, and/or antibodies.08-21-2008
20080201788Mouse in which genome is modified - A mouse or progenies thereof in which genome is modified so as to have decreased or deleted activity of an enzyme relating to modification of a sugar chain in which the 08-21-2008
20110225660ORALLY ADMINISTRABLE IMMUNOSTIMULANT PRODUCT FOR AQUACULTURE - An orally administrable immunostimulant product comprises a microencapsulated cytokine and an enteric protection polymer to protect the cytokine, the cytokine is a fish, mollusc or crustacean cytokine, preferably a recombinant cytokine such as tumor necrosis factor α (TNFα) over-expressed in a host microorganism.09-15-2011
20110258712MYOSTATIN ISOFORM - The present invention provides splice variants of myostatin that promote muscle growth, and include polynucleotides and polypeptide sequences, constructs comprising the sequences and compositions for regulating muscle growth and treating diseases associated with muscle tissue. The splice variants include the consensus sequence X10-20-2011
20100319077METHOD OF IMPROVING SALMON MEAT COLOR - The present invention provides a salmon flesh color improving method and a salmon flesh color improving feed which are usable for producing a salmon having a mild reddish orange flesh color close to the flesh color of wild fish, and a salmon and fish flesh thereof produced by such a flesh color improving method. The present invention also provides a method for producing a salmon having a mild reddish orange flesh color, comprising cultivating the salmon with a feed comprising a carotenoid colorant mixed therein, the carotenoid colorant comprising at least astaxanthin, phoenicoxanthin, canthaxanthin and adonixanthin.12-16-2010
20130185817Microencapsulated Volatile Insect Repellent and/or Insecticide Agent and Methods of Making and Using the Same - This disclosure is particularly directed to arthropodal compositions in the form of capsules containing an active arthropod agent, more particularly to capsules containing an active arthropod agent and methods of making and using the same. The active arthropod agent may be an insect repellent and/or an insecticide agent.07-18-2013
20130191932METHODS OF SELECTING HOST RESISTANT ANIMALS - The present invention is directed to a method of selecting animals that are genetically resistant to one or more intestinal parasite infections by testing mucus samples for the presence of an antibody against one or more of said intestinal parasites and segregation and selecting the animals that test positive. The animals that test negative are less parasite resistant and can be subjected to parasite management regimes.07-25-2013
20120096570BASE FOR PROPAGATING AQUATIC ANIMALS - An aquatic animal such as coral is propagated on a base. The base has a top portion with a groove located therein. The groove has converging side walls. The groove intersects a depression that extends from the top portion to a bottom portion of the base. The depression has converging sides. An animal fragment is secured to the base by locating it in the groove, or alternatively in the groove and the depression. Water flow across the base may cause the fragment to move inside of the groove, wherein the fragment will sink down and become wedged in place, further securing or coupling the fragment to the base. The coral then grows and adheres itself to the base.04-19-2012

Patent applications in class NONHUMAN ANIMAL

Patent applications in all subclasses NONHUMAN ANIMAL