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Biological or biochemical

Subclass of:

702 - Data processing: measuring, calibrating, or testing

702001000 - MEASUREMENT SYSTEM IN A SPECIFIC ENVIRONMENT

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Class / Patent application numberDescriptionNumber of patent applications / Date published
702020000 Gene sequence determination 139
702021000 Cell count or shape or size analysis (e.g., blood cell) 47
Entries
DocumentTitleDate
20110178719Methods for Allele Calling and Ploidy Calling - Disclosed herein is a system and method for making allele calls, and for determining the ploidy state, in one or a small set of cells, or where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed and the haplotypes are determined using expected similarities between the target genome and the knowledge of the genomes of genetically related individuals. In one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the genetic data from both parents, and possibly one or more sperm and/or sibling embryos. In another embodiment, the chromosome copy number can be determined using the same input data. In another embodiment, these determinations are made for embryo selection during IVF, for non-invasive prenatal diagnosis, or for making phenotypic predictions.07-21-2011
20110178718CHARACTERIZATION OF BIOLOGICAL SAMPLES - A method of characterizing a biological sample comprising separating the biological sample into constituents; observing the separated constituents; applying statistical classification modeling to the observed constituents; deriving quantifiable data from the applied statistical classification modeling; and analyzing the data from the applied statistical classification modeling to assess a donor of the biological compounds' health. A system for characterizing a biological sample comprising a biological sample separator, wherein the biological sample separator functions to separate the biological sample into constituents; a constituent observer, wherein the constituent observer functions to confirm and qualify the presence of the constituent; a constituent statistical processor, wherein the constituent statistical processor functions to apply statistical classification modeling to the observed constituent to derive representative data; and a statistical analyzer, wherein the statistical analyzer functions to compare the representative data to benchmark values to derive a predictor for a health concern. Also disclosed is a method comprising identifying a disease of interest; identifying one or more organisms having the disease of interest; obtaining one or more biological samples from the organisms having the disease of interest; identifying one or more characteristics of the biological samples; providing quantifiable data that represents the characteristics of the biological sample; and employing a statistical classification method that utilizes the quantifiable data to identify one or more discriminant directions wherein the discriminant directions relate the characteristics of the biological sample to the disease of interest.07-21-2011
20110178717Diabetes Care Host-Client Architecture and Data Management System - A host-client data sharing system manages diabetes care data. A host database, preferably web or internet based, is implemented for storing diabetes care data relating to multiple diabetics. A client or local database stores the diabetes care data relating to multiple diabetics on a personal appliance such as a PC, or a portable or handheld microprocessor-based computing device. The host database uses multiple servers for handling client interactions with the system.07-21-2011
20130030713METHODS OF ASSOCIATING AN UNKOWN BIOLOGICAL SPECIMEN WITH A FAMILY - The present invention provides a method of predicting whether an unknown biological specimen originates from a member of a particular family. The method compares DNA profiles from at least one unknown biological specimen to DNA profiles of more than one family member, which significantly increases the methods' predictive ability. In particular, the invention describes a method of comparing test DNA profiles from unknown biological specimens to a family pedigree comprising target DNA profiles obtained from biological specimens of family members. In one embodiment, a modified Elston Stewart algorithm is used to determine a probability that a genetic relationship exists between at least one unknown biological specimen and the family pedigree.01-31-2013
20130030712METHODS FOR THE SURVEY AND GENETIC ANALYSIS OF POPULATIONS - The present invention relates to methods for performing surveys of the genetic diversity of a population. The invention also relates to methods for performing genetic analyses of a population. The invention further relates to methods for the creation of databases comprising the survey information and the databases created by these methods. The invention also relates to methods for analyzing the information to correlate the presence of nucleic acid markers with desired parameters in a sample. These methods have application in the fields of geochemical exploration, agriculture, bioremediation, environmental analysis, clinical microbiology, forensic science and medicine.01-31-2013
20130030711METHOD AND APPARATUS FOR PROVIDING ADAPTIVE FILTERING OF SENSORS AND SENSOR DATA - An approach is provided for adaptive filtering of sensors and sensor data. A sensor manager determines one or more signals associated with one or more sensors. The sensor manager then processes and/or facilitates a processing of the one or more signals for comparison against one or more predetermined signals. The sensor manager determines one or more parameters for one or more filters based, at least in part, on the comparison, wherein the one or more filters operate, at least in part, on the one or more sensors, one or more other signals determined form the one or more sensors, or a combination thereof.01-31-2013
20100161237Method and System for Genotyping Samples in a Normalized Allelic Space - Aspects of the present invention describe an apparatus and method for generating genotype calls for a sample. The genotyping initially models allelic signal response into an allelic model having one or more model parameters for an identified one or more sources of systematic variation. The model and parameters are then used to transform the allelic signals to a normalized normalized allelic space that serves to compensate for the one or more sources of systematic variation. By compensating for the systematic variation in this manner, the genotype for the sample is readily determined based upon its relationship to the representation of the allelic signals in normalized allelic space and in accordance with the allelic model.06-24-2010
20110184649Method of Assessing Risk in an Area - A method and system for the evaluation of the probability for the presence of suspicious materials is presented. The proposed system will be able to continuously monitor a large area or a gate passage, without a specific need for a manual full-body search or manual inspection or the use of sniffers or sniffing dogs (although the system can be embedded within such a gate), and will allow to detect suspicious materials, not by identifying the specific material, but rather by at least one of the chemical and/or physical analysis of the commonality of all detected materials against the statistical accumulation database of all material properties that were presented to the system in the past.07-28-2011
20090222213AUTOMATIC ANALYZER - The present invention provides an index that makes it possible to use, in an automatic analyzer, an approximate expression based on a theoretical chemical reaction formula derived from reaction process data, and automatically check for apparatus abnormalities, reagent deteriorations, and improper accuracy control during each continuous or individual inspection.09-03-2009
20110208433Cancer patient selection for administration of therapeutic agents using mass spectral analysis of blood-based samples - Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a solid epithelial tumor cancer patient is likely to benefit from a therapeutic agent or a combination of therapeutic agents targeting agonists of the receptors, receptors or proteins involved in MAPK (mitogen-activated protein kinase) pathways or the PKC (protein kinase C) pathway upstream from or at Akt or ERK/JNK/p38 or PKC, such as therapeutic agents targeting EGFR and/or HER2. The methods also provide the ability to determine whether the cancer patient is likely to benefit from the combination of a therapeutic agent targeting EFGR and a therapeutic agent targeting COX2; or whether the cancer patient is likely to benefit from the treatment with an NF-κB inhibitor.08-25-2011
20090012714Test of amino acid sequence constituting peptide using isotopic ratio - It is an object of the present invention, when determining and identifying an amino acid sequence of a peptide using MS, to obtain additional information from the MS for evaluating validity of an amino acid sequence in a candidate list outputted from an identifying engine. The present invention provides a method of testing an amino acid sequence inferred by searching a peptide-related database based on peptide mass information and/or peptide modification information obtained through mass spectrometry on a peptide, the method comprising the steps: (1) calculating a theoretical value of an isotopic ratio for the peptide from the inferred amino acid sequence and/or the peptide modification information; (2) measuring a measured value of the isotopic ratio for the peptide from the peptide mass information; and (3) comparing the theoretical value and the measured value, and evaluating validity of the inferred amino acid sequence from differences between the theoretical value and the measured value.01-08-2009
20090138207GLUCOSE METER SYSTEM AND MONITOR - A handheld portable glucose meter, includes a glucose sensor having a sensor output related to glucose in a blood sample on a blood glucose test strip. A display is configured to display information to a user. The handheld portable glucose meter maintains information related to a depletion of a supply of materials. The handheld portable glucose meter is configured to communicate with a remote location and to send data to the remote location to reorder the supply.05-28-2009
20090192722SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA - Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided.07-30-2009
20090192721METABOLIC PHENOTYPING - A method of generating models with which to characterise selected aspects of the metabolic phenotype of subjects without dosing a test substance to those subjects or with which to predict, without dosing, the post-dose responses of subjects where those responses are dependent on metabolic phenotype, the method comprising: obtaining pre-dose data relating to a plurality of subjects before dosing with a dosing substance; obtaining post-dose data relating to the plurality of subjects after dosing with the dosing substance; and correlating inter-subject variation in the pre-dose data with inter-subject variation in the post-dose data, and generating a pre-to-post-dose predictive model on the basis of the observed correlation. The models may be used to determine selected aspects of the metabolic phenotype of a subject or to predict, without dosing, the post-dose responses of subjects. This is achieved by analysing data relating to the un-dosed subject in relation to a model describing the correlation of pre-dose and post-dose data relating to a plurality of subjects when dosed with a particular substance which challenges the biochemical transformation or pathway of interest; and generating, according to the predetermined criteria of the model, a numerical measure or classification describing the metabolic phenotype of the un-dosed subject.07-30-2009
20090192720METHODS AND COMPOSITIONS FOR DETERMINING ENZYMATIC ACTIVITY AND SPECIFICITY OF METHYLTRANSFERASES - The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the activity or substrate specificity of putative O-methyl-transferases, methods of identifying potential substrates of O-methyltransferases, and methods of identifying potential inhibitors of methyltransferases.07-30-2009
20090192719Exploratory visualization of protein complexes by molecular weight - Methods, user interfaces, systems and computer readable media for visualizing data to facilitate analysis of the data. Mass data values are provided for a sample having been separated into portions according to a first characteristic of the sample, the slices having been processed to provide the mass data values of members of the sample occurring in the portions. A plot of the mass data values is displayed on a first axis versus the portions on a second axis of the plot. A mass data value of a member may be selected on the plot, and all mass data values occurring in the portion in which the selected mass data value is located are displayed using first visual indicators that are visibly distinct from visual indicators used to display data values occurring outside of the portion in which the selected data value is located.07-30-2009
20110196619METHOD FOR PREDICTING BIOLOGICAL RHYTHM - There is provided a method that achieves the prediction of a biological rhythm with high precision while minimizing the number of times a biological specimen is collected from a subject. There is also provided a method for predicting a biological rhythm of a subject on the basis of time series expression level data obtained by measuring expression levels of two clock genes in biological specimens collected from the subject three times within 24 hours, the clock genes having different phases of circadian cycles of a change in expression levels. In this method for predicting a biological rhythm, a biological rhythm can be predicted with particularly high precision by collecting a biological specimen from a subject three times within 24 hours at eight-hour intervals.08-11-2011
20110196617REMOVABLE HANDHELD UNIT - A measuring device including a sensor that generates data representing a detected body parameter, such as body fat, body water and weight of an individual. A portable device removably connected to the measuring device for receiving, displaying and storing the data representing the detected body parameter. The portable device may correlate the stored data with an individual user. The portable device is responsive to a personal computer for uploading the stored information thereto.08-11-2011
20110196616APPARATUS FOR AND METHOD OF MEASURING PERCEIVED AGE - This invention relates to an apparatus for and a method of measuring skin glow and/or skin radiance and/or skin shine and/or the biological age of the skin of an individual.08-11-2011
20110196615Processing of biological signals - A method processes a signal by storing a template sequence composed of a number N of consecutive digital samples of the signal; calculating a sequence of extended sums that includes, for each digital sample, an extended sum of absolute values of differences between N most recent digital samples and the samples of the template sequence; detecting minima of the sequence of extended sums; and estimating a period of the signal as a time interval between two consecutive minima of the sequence of extended sums. The method also estimates the noise level of the signal as a ratio between most recently-detected minimum and maximum of said sequence of extended sums. The method also generates a reduced-noise replica of the signal as a weighted average of the template sequence and of the current samples of the signal processed between two consecutive minima of said extended sum, the weighted average being calculated using weights based on the estimated noise level.08-11-2011
20110196614BLOOD TRANSCRIPTIONAL SIGNATURE OF MYCOBACTERIUM TUBERCULOSIS INFECTION - The present invention includes methods, systems and kits for distinguishing between active and latent 08-11-2011
20080270036SYSTEMS AND METHODS FACILITATING AUXILIARY ANALYSIS OF DATA FROM IMPLANTED MEDICAL DEVICES - Systems and methods facilitating auxiliary analysis of data collected by an implanted medical device employ a software application user interface, through which an analysis service may be invoked for a selected group of data sets collected from an implanted device; the group of data sets includes data sets that describe episodes detected and classified by an analysis performed by the device, and/or data sets that describe events indicative of a device integrity issue. The user interface informs, or notifies a user of the system if any of the results warrant further review of the corresponding data sets, and may display an organized report of results from the automated analysis. The report may be organized such that those results, which warrant further review, are displayed in a more prominent fashion than other results.10-30-2008
20130211728METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW - Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.08-15-2013
20110295518METHODS OF ASSOCIATING AN UNKNOWN BIOLOGICAL SPECIMEN WITH A FAMILY - The present invention provides at least three methods of predicting whether an unknown biological specimen originates from a member of a particular family. These methods compare DNA profiles from unknown biological specimens to DNA profiles of more than one family member, which significantly increases the methods' identification ability. In particular, the invention describes combining at least a ranked first family member list and a ranked second family member list to create a combined ranked list and identifying the unknown biological specimen as one contained among a list of specimens having the highest combined rankings representing the candidates that are most likely related to the family. A second method encompasses comparing test DNA profiles from unknown biological specimens to a family pedigree comprising target DNA profiles obtained from multiple biological specimens of family members. This method also embodies using a modified Elston Stewart algorithm to determine a pedigree likelihood ratio to rank and identify the test profile of the unknown biological specimen most likely to be the missing person sought after by the corresponding family represented by the family pedigree. A third method encompasses construction of a database or directed graph of discovered or known relationships between biological specimens and comparison to a graph representing a family pedigree to identify portions of the database or directed graph that correspond to portions of the family pedigree, in order to rank or identify one or more unknown biological specimens as most likely related to one or more family pedigrees.12-01-2011
20110202285NMR METHOD FOR DIFFERENTIATING COMPLEX MIXTURES - A method for differentiating complex mixtures each having one or more chemical species is provided. The method comprises producing a sample NMR spectrum by subjecting a mixture to a selective spectroscopy process, wherein the NMR spectrum has individual spectral peaks representative of the one or more chemical species within the mixture. The one or more chemical species within the mixture are identified by analyzing the individual spectral peaks, and the individual spectral peaks are then subjected to a multivariate statistical analysis.08-18-2011
20110202284NOVEL GROUPS OF BIOMARKERS FOR DIAGNOSING ALZHEIMER'S DISEASE - The inventors have discovered sets of proteinaceous biomarkers which can be measured in biological fluid samples to diagnosis or aid in the diagnosis of Alzheimer's disease and distinguish AD samples from non-demented samples.08-18-2011
20110202283SYSTEMS AND METHODS FOR FAULT DIAGNOSIS IN MOLECULAR NETWORKS - The present disclosure provides advantageous systems and methods for identifying molecular vulnerabilities in biological pathways and networks. The present disclosure generally involves conceptualizing a disease/disorder at the molecular level as a faulty physiological system, wherein one or more molecules in the complex intracellular signaling network are dysfunctional. This is accomplished by modeling a given physiological system as a digital logic circuit. More particularly, in exemplarily embodiments, binary logic equations are derived by analyzing the interactions between the input and output nodes of a target biological system. These equations are then used to produce a digital circuit representation for the system. Once a digital circuit representation is created, this circuit may advantageously be analyzed, using fault analysis techniques, in order to determine the vulnerability levels of the molecules of the targeted system.08-18-2011
20110202281ADAPTIVE BIOCHEMICAL SIGNATURES - The present invention is related to methods of generating adaptive biochemical signatures in live cells and the use of said signatures to identify diagnostic and therapeutic modalities for human disease. The methods described herein comprise contacting a provocative agent to live cells and measuring and analyzing adaptive readouts. The methods of the invention may be used for therapeutic or diagnostic purposes.08-18-2011
20110202280SYSTEMS AND METHODS FOR ERROR CORRECTION IN DNA SEQUENCING - Disclosed are systems and methods for polynucleotide sequencing where detection and correction of base calling errors can be achieved without reliance on a reference sequence. In certain embodiments, redundant information can be introduced during measurement so as to allow such detection of errors. Such redundant information and measurements can be facilitated by encoding of nucleotide sequence being measured. Various examples of such encoding, redundancy introduction, and decoding are provided.08-18-2011
20110202279METHOD AND SYSTEM FOR TRAIT EVALUATION THROUGH QUANTITATIVE GENOTYPING - Method for determining in a mixed population of biological organism percentage of individuals originated from two or more contributing populations by quantitative genotyping of the mixed population or samples thereof, without the need to identify or separate the individuals. Also disclosed are methods of determining the survival rate of individuals, growth rate of individuals, and increase in biomass of each of the contributing populations, and the impact of environmental conditions on the survival or growth or increase in biomass of the contributing populations. Also disclosed are methods to study population dynamics in mixed populations of microbes. In addition methods are disclosed to trace chromosomal segments back to founder populations or individuals.08-18-2011
20100076692Movement And Event Systems And Associated Methods - A method for monitoring fractional weight supported by one foot of a person, comprising the steps of adhering a movement monitor device underneath the foot such that the device is compressed when weight is applied to the foot; generating wireless signals representative of a target fractional weight of a total weight of the person; remotely receiving the wireless signals as information of the fractional weight. A method of monitoring weight of a person, comprising the steps of arranging one or more weight sensitive detectors underneath a foot of the person; processing signals from the detectors to determine weight; and wirelessly communicating the weight to a remote receiver.03-25-2010
20100076690METHOD AND SYSTEM FOR ANALYSIS OF MELT CURVES, PARTICULARLY dsDNA AND PROTEIN MELT CURVES - A computer-implemented method of analysis of melt curve data comprising the steps of: (a) parameter model fitting the melt curve data; (b) performing a principal component analysis of the melt curve data; and (c) utilizing the principal components for clustering the melt curve data into groups. Such a method allows an efficient analysis of variations in melt curve shape and position and allows to statistically quantify these variations for both supervised and unsupervised data sets. Current melt analysis methods neither allow for statistical measures of each unknown nor do they allow for the determination of unsupervised data sets (i.e., unknown number of groups present). Particularly, the method according to the invention can be advantageous for identifying a specific sequence of dsDNA in a sample after performing a polymerase chain reaction (PCR).03-25-2010
20100076689Method for extracting waveform attributes from biological signals - A computer-based method for extracting waveform attributes from a biological (bio) signal includes the steps of receiving a raw waveform data corresponding to the bio signal, upon receiving a user-initiated signal, communicating the raw data to a first waveform analysis tool to obtain a first waveform attribute, and upon receiving the same user-initiated signal, communicating the raw data to a second waveform analysis tool to obtain a second waveform attribute. The first tool is different from the second tool and the first attribute is different from the second attribute. The method also includes outputting the first and second waveform attributes into a human-readable format.03-25-2010
20100076691Diagnosis of Metastatic Melanoma and Monitoring Indicators of Immunosuppression Through Blood Leukocyte Microarray Analysis - The present invention includes compositions, systems and methods for the early detection and consistent determination of metastatic melanoma and/or immunosuppression using microarrays by calculating one or more expression vectors from the expression of one or more genes.03-25-2010
20100114498METHOD FOR DETERMINING ISOTOPIC CLUSTERS AND MONOISOTOPIC MASSES OF POLYPEPTIDES ON MASS SPECTRA OF COMPLEX POLYPEPTIDE MIXTURES AND COMPUTER-READABLE MEDIUM THEREOF - Disclosed herein is a method of finding an isotopic cluster in a polypeptide and determining the monoisotopic mass of the cluster. The method comprises an algorithm for finding an isotopic cluster based on a probabilistic model, defined by each of peaks in the isotopic cluster, and determining the monoisotopic mass of the isotopic cluster. The probabilistic model of the isotopic cluster includes characteristic functions for mass, that is, a function of the ratio of two peak intensities, and a function of the product of two ratios obtained from three peaks. These characteristic functions for mass define the shape of peaks acceptable in an actual isotopic cluster for the mass of any isotopic cluster. The algorithm of finding the isotopic cluster based on the functions uses the characteristics to score the degree of the approximation of any isotopic cluster to the spectral shape of a theoretical cluster. First, peaks that can be included in the same isotopic cluster at a distance of 1 Da are found, and then the score is calculated in consideration of, whether the ratio and the product of ratios of peak intensities falls in the range of the previously defined maximum and minimum values of the characteristic functions, and the similarity to the average value. Accordingly, each of isotopic clusters can be determined, and finally, isotopic clusters having an overlapping peak are removed such that each peak is included only in one isotopic cluster, and the monoisotopic mass of each isotopic cluster is determined.05-06-2010
20100114497Compositions and methods for therapeutic delivery with frozen particles - Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.05-06-2010
20130080069Method to Estimate Likelihood of Pathogenicity of Synonymous and Non-coding Variants Across a Genome - A method according to an embodiment of the present invention determines putative changes in splicing, mRNA structure, and protein synthesis. For each of these concepts, scoring algorithms are disclosed that can be used in a genome-wide scale. The described methods provide a pipeline that can be used to analyze the biological effects of SNPs generally, both synonymous and non-synonymous.03-28-2013
20130080068Phased Whole Genome Genetic Risk In A Family Quartet - An embodiment of the present invention is a methodology for prioritizing variants relevant to inherited Mendelian (“single gene”) disease syndromes according to disease phenotype, gene, and variant level information.03-28-2013
20130080070CHEMOMETRICS FOR NEAR INFRARED SPECTRAL ANALYSIS - This disclosure concerns systems and methods for identifying and selecting a more accurate chemometric model for the analysis of specific plant samples via near infrared spectrometry. This disclosure further concerns the use of such systems and methods to identify characteristics and traits of interest in plants and plant samples, for example, to facilitate selective breeding, quality control, and/or inventory control.03-28-2013
20130085678METHODS AND SYSTEMS FOR COMPARING MEDIA CONTENT - Avatars, methods, apparatuses, computer program products, devices and systems are described that carry out presenting to at least one member of a population a plurality of avatars associated with at least one instance of media content; measuring at least one physiologic activity of the at least one member of the population, the at least one physiologic activity proximate to at least one presented avatar among the plurality of avatars associated with at least one instance of media content; associating the at least one physiologic activity with at least one mental state; and identifying at least one instance of media content based on the at least one mental state.04-04-2013
20130085680System, Apparatus and Method for Evaluating Samples or Analytes Using a Point-of-Care Device - A system, apparatus and method evaluates samples or analytes using a point-of-care device. A test selection is received from the user interface. A determination is made whether a test cartridge connected to the test cartridge interface matches the test selection. Properties of the sample or the analyte are detected using detector(s) or sensor(s) in the POC device. A test results data based on the properties is generated. A report based on an analysis of the test results data is generated and the report is provided to the user interface of the POC device. The POC device also includes memory, communication interface(s), test cartridge interface, and processor(s).04-04-2013
20130085681METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS - Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.04-04-2013
20130085679Methods, Devices and Systems for Analyte Monitoring Management - Methods of analyte monitoring management are provided. The methods include indicating on a user interface a plurality of analyte management procedures available for user-selection, where the plurality of analyte management procedures relate to analyte management parameters. Embodiments include receiving an indication to initiate a first procedure of the plurality of analyte management procedures, where the first procedure is for determining a first analyte management parameter. The methods may further include outputting user-instructions associated with the first procedure; receiving analyte measurement data for the first procedure; estimating the first analyte management parameter based on the analyte measurement data; calculating a degree of certainty for the estimation of the first analyte management parameter; and, initiating an action in response to an event associated with a status of the estimation of the first analyte management parameter or the degree of certainty. Analyte monitoring devices and systems implementing the methods are also provided.04-04-2013
20130085677TECHNIQUES FOR IMPROVED PEDOMETER READINGS - Techniques are provided for improving pedometer readings. In some embodiments, motion data, such as acceleration data is detected, and a magnitude of the acceleration data, referred to as the modulus, is processed. The modulus is used to detect walking steps and running steps during a measurement. In some embodiments, a distance ran is calculated based on the detected running steps and an estimated running stride length, and a distance walked is calculated based on the detected walking steps and an estimated walking stride length. The estimated running and walking stride lengths are calculated based on various parameters associated with the acceleration data, population data, and user-specific data. Expended calories may be estimated based on the distance ran and walked. The distance analysis process further includes calibration techniques, including, for example, least squares simple regression, least squares multiple regression, and K-factor analysis.04-04-2013
20100004873METHOD OF PROCESSING BIOLOGICAL ANALYSIS DATA AND EXPERT SYSTEM OF BIOLOGICAL ANALYSIS APPLYING THIS METHOD - An expert system of biological analysis includes a collecting engine to collect and represent data resulting from biological measurements carried out on a human or animal subject and defining a biological profile, and personal data relating to the human or animal subject.01-07-2010
20100145626Systems for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy - The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.06-10-2010
20090070046METHOD OF MEASURING DAILY URINARY EXCRETION AND APPARATUS FOR MEASURING DAILY URINARY EXCRETION - A daily urinary excretion measurement apparatus and a method thereof, for measuring daily excretion of a urine component highly accurately and easily, are provided.03-12-2009
20090187348Sample processing apparatus, method of outputting processing result by sample processing apparatus, and computer program product - Disclosed is a sample processing apparatus, comprising: a sample processing unit for processing a sample with an auxiliary item used to process the sample; an output device for outputting a processing result by the sample processing unit; and a controller for determining whether or not the auxiliary item is appropriate for the sample processing by sample processing unit, and controlling, when determining that the auxiliary item is not appropriate for the sample processing by the sample processing unit, the output device so as to output the processing result and reliability information showing that the processing result has a low reliability. Also disclosed is a method for outputting the processing result by the sample processing apparatus and a computer program product.07-23-2009
20130138355METHOD AND SYSTEM FOR EVALUATING SEQUENCES - A method of evaluating correlation between sequences by employing a hierarchy of evaluation algorithms. The evaluation algorithms may be arranged in order of computational efficiency as specified by a user or as determined by the system. The algorithms may range from a simple equality algorithm through to seeded alignment algorithms etc.05-30-2013
20090177406Slope-Based Compensation - A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals with one or more index functions extracted from the output signals. The index functions determine at least one slope deviation value, ΔS, or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias.07-09-2009
20080300795Evaluating the probability that MS/MS spectral data matches candidate sequence data - In one aspect of the present invention a new database search methodology is provided that provides a probability that spectral data from a non-ergodic reaction via mass spectrometry matches a candidate sequence from a set of sequences in a database by random. The methodology comprises two parts. The first part pre-processes the spectral data and retains only the most relevant data for the database search. The second part comprises searching a database using the pre-processed spectrum to assign a probability or expectation that the spectrum matches a candidate sequence from a set of sequences in a database by random. The search methodology uses a new probability model, a compound distribution based on the number of product ion mass-to-charge ratios and the number of intensity values that are shared between the product ion spectral data and the sequence database, to accurately predict the probability of the peptide identification being a correct match, and not a random event.12-04-2008
20090187350BIOSENSING APPARATUS AND SYSTEM - A bio-sensing system comprises a light source, a bio-sensing apparatus, a detecting platform, and a processing unit. A bio-sensing apparatus further comprising a substrate, a sample with at least one analyte, at least one grating bound on the substrate for diffracting a light beam in a reflection mode and outputting at least one output light beam, a plurality of nanoparticles being bound on one side of the grating, a molecular recognition unit bound on said nanoparticle surface, and a cover plate covering the nanoparticle-modified side of the substrate. The detecting platform receives a signal while the at least one output light beam passing through the bio-sensing apparatus. The processing unit couples with the detecting platform for receiving and analyzing the signal. Wherein when the analyte passes through the microfludic channel to contact with said nanoparticles, the at least one output light beam changes in accordance with the refractive index of the sample or in accordance with the interaction of the analyte with said molecular recognition unit bound on said nanoparticle surface.07-23-2009
20130041592Method And System Using Computer Simulation For The Quantitative Analysis Of Glycan Biosynthesis - This invention provides a quantitative analysis of glycan biosynthesis along meta pathways using computer simulation for comparing a computer generated spectrum to experimental data to quantitatively track the biosynthesis. Computer simulating the mass spectra of isotopic detection of aminosugars with glutamine experiments allows modeling the glycan biosynthesis over time, via changes in the 02-14-2013
20130041591MULTIPLE MEASUREMENT MODE IN A PHYSIOLOGICAL SENSOR - In a physiological sensor that estimates a true parameter value by providing a predicted parameter value, multiple measurements are taken to increase the accuracy of the predicted parameter value. The sensor can be reapplied between measurements to decrease the probability of an erroneous prediction caused by sensor misplacement. Some measurements can be discarded before calculating a predicted parameter value. The physiological sensor can have a plurality of modes, with one of the modes corresponding to multiple measurement process.02-14-2013
20130041590Group Performance Monitoring System and Method - The present invention provides a group monitoring device for monitoring a plurality of individuals engaged in an athletic activity, the device including a display configured to display, during an athletic activity: a metric relating to each of a plurality of individuals engaged in the athletic activity, and a status of a system component used to monitor the athletic activity. The group monitoring device may also include an input configured to allow manipulation of the display.02-14-2013
20100114499SYSTEM AND METHOD FOR PROCESSING RAW ACTIVITY ENERGY EXPENDITURE DATA - According to one embodiment, a method is provided for calculating, by an activity monitor comprising one accelerometer, a raw activity energy expenditure data based on movement by a user. The method includes determining if the raw activity energy expenditure data is associated with a high intensity physical activity, wherein the high intensity physical activity causes the raw activity energy expenditure data to differ from an expected activity energy expenditure data. The method includes calculating a corrected activity energy expenditure data, if the raw activity energy expenditure data is associated with the high intensity physical activity, based on the raw activity energy expenditure data, wherein the corrected activity energy expenditure data is substantially identical to the expected activity energy expenditure data.05-06-2010
20100100334LIPOPROTEIN INSULIN RESISTANCE INDEXES AND RELATED METHODS, SYSTEMS AND COMPUTER PROGRAMS FOR GENERATING SAME - Methods, reports and systems for generating insulin resistance indexes for assessing decreased insulin sensitivity and/or levels of insulin resistance using a plurality of different measured lipoprotein particle parameters.04-22-2010
20100100333HUMAN BIOMARKER HYPERMAPPING FOR DEPRESSIVE DISORDERS - Materials and Methods related to diagnosing depression disorders, or determining a subject's predisposition to develop a depression disorder, using a multi-parameter hypermapping system and algorithms related thereto.04-22-2010
20130035868METHOD FOR QUANTIFYING THE EXTENT OF HUMAN-INTRODUCED VARIABILITY IN MEDICAL TEST DATA - A method for quantifying the extent of human-introduced variability in medical test data relative to one or more standards for comparable medical tests, the method comprising the following steps: providing user medical test data; comparing the user medical test data against one or more standards for comparable medical tests to determine the extent of deviation of the user medical test data from the one or more standards; and generating a variability-value corresponding to the maximum absolute percentage deviation of the user medical test data from the one or more standards over a predefined operating range of values for the one or more standards.02-07-2013
20130035867INTENSITY NORMALIZATION IN IMAGING MASS SPECTROMETRY - The present invention relates generally to a species (analyte) separation and analysis system, for instance a spectrometry system, comprising a processor for receiving and processing signals from said its detector to remove undesirable variation or noise before further processing into a spectrum, whereby the processor is programmed by a novel program, for a normalization preprocessing of the signals of said separation and analysis system.02-07-2013
20130035866INSTRUMENT AND METHOD FOR ACQUIRING SIGNALS AND IMAGES RELATING TO THE GASTROINTESTINAL TRACT - This invention relates to an apparatus and method for improving detection by equipment used to detect magnetic susceptibility. The advantages provided are related to different factors, such as reduced instrumentation cost, performance in terms of stability and sensitivity, etc. The devices may be used, for example, to detect magnetic tracers and markers in the gastrointestinal tract of animals and humans. They can be used in research and/or for diagnostic purposes using information related to a variety of parameters of the gastrointestinal tract, such as, pharyngeal and oesophageal transit time, gastric emptying and motility, colonic motility, inter alia.02-07-2013
20130035865SYSTEMS AND METHODS FOR DETECTING GLUCOSE LEVEL DATA PATTERNS - Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges.02-07-2013
20130035864Technique for identifying association variables - During a method, an apparatus determines patterns of occurrence of compound variables based on a set of mathematical interactions and patterns of occurrence of a set of biological variables of a group of life forms. Then, the apparatus calculates statistical relationships corresponding to a pattern of occurrence of a trait in the group of life forms and the patterns of occurrence of the compound variables. Moreover, the apparatus determines numbers of occurrences of biological variables that were used to determine compound variables in at least a statistically significant subset of the compound variables, and determines numbers of different mathematical interactions that were used to determine the compound variables in the subset of the compound variables for the biological variables that are associated with the corresponding numbers of occurrences. Next, the apparatus identifies one or more of the biological variables as one or more association variables based on the numbers of occurrences and the numbers of different mathematical interactions.02-07-2013
20100042329MULTIPARAMETER ANALYSIS FOR PREDICTIVE MEDICINE - The invention provides a method of determining a comparative expression profile in an individual by comparing the expression levels of a sample of molecules in a population of molecules in a specimen from the individual with a health-associated reference expression region of the sample of molecules, wherein expression levels within the health-associated reference expression region indicate a reference expression profile and wherein expression levels outside the health-associated reference expression region indicate a perturbed expression profile. The invention also provides methods of diagnosing a disease or a health state in an individual by comparing the expression level of a sample of molecules in a specimen from the individual with a health-associated reference expression region of the sample of molecules.02-18-2010
20100042331PLANNING METHOD AND APPARATUS FOR PERITONEAL DIALYSIS AND HEMODIALYSIS HYBRID REMEDY - The present invention is a peritoneal dialysis and hemodialysis hybrid-remedy planning method using an index that is shared by both peritoneal dialysis and hemodialysis and indicates an effect of dialysis. To be specific, the index is M/C(0)/V02-18-2010
20100324828SENSOR DEVICE FOR AND A METHOD OF SENSING MAGNETIC PARTICLES - A sensor device (12-23-2010
20090157328METHOD OF DETERMING EXCRETION OF SODIUM AND OTHER ANALYTES - Methods and kits of the invention are useful for calculating 24-hour excretion of sodium without the need to collect urine for 24 hours.06-18-2009
20090157326Diagnosis and prognosis of breast cancer patients - The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.06-18-2009
20090157325BIOSIGNAL MEASURING APPARATUS - A biological signal measuring apparatus includes a first biological signal measuring sensor attached to an earphone used for a mobile phone; and a biological signal receiver for receiving a biological signal from the first biological signal measuring sensor to thereby generate first raw data. The apparatus may further include a second biological signal measuring sensor attached to one of the mobile phone and an adaptor connected to the mobile phone, wherein the biological signal receiver receives a biological signal from the second biological signal measuring sensor to thereby generate second raw data. The apparatus is provided with a controller for detecting whether the mobile phone is used, wherein the controller drives the first and the second biological signal measuring sensor to measure the biological signal when the mobile phone is being used, and stops measuring the biological signals when the use of the mobile phone is finished.06-18-2009
20090157324Method for Analyzing Gene Expression Data - The invention provides a method for selecting one or more genes from among a predetermined group of genes whose expression level is significantly different among a first group of individuals in a population in comparison with a second group within the population. The first group of individuals may be, for example, a group of individuals suffering from an illness that responded to a predetermined treatment. The second group of individuals may be a group of individuals suffering from the same illness that did not respond to the treatment. In accordance with the method of the invention, for each of one or more selections of m individuals from the first subset and n individuals from the second subset, the statistical significance of each gene i in the up group of the genes, and in the down group of genes are determined, where the up group is a group of genes for which the expression level in the first group is greater than an expression level in the second group and the down group is a group of genes for which the expression level in the first group is less than an expression level in the second group. The genes in the up and the down groups are ranked according to the number of times each gene received the highest statistical significance among the one or more selections of individuals. A subset of genes in the up group having the highest rankings and a subset of genes in the down group having the highest rankings are then selected.06-18-2009
20090157323Methods and systems for specifying an avatar - Avatars, methods, apparatuses, computer program products, devices and systems are described that carry out presenting at least one characteristic to at least one member of a population cohort; measuring at least one physiologic activity of the at least one member of the population cohort, the at least one physiologic activity proximate to the at least one presented characteristic; associating the at least one physiological activity with at least one mental state; and specifying at least one avatar attribute based on the at least one mental state.06-18-2009
20100106426REGIONS OF INTEREST PROCESSING - After prepared biological samples have been submitted to liquid-chromatography/mass spectrometry equipment, digital images are produced that show variations. Some of these variations may be of interest while others are not of interest. Variations in regions of interest can be correlated and correlation scores produced to classify biological features aid in scientific discovery. Shape properties of variations can also be calculated by geometric scores. A microalignment method aids the correlation calculation without resorting to macroalignment.04-29-2010
20100106427SAMPLE ANALYZER - A sample analyzer comprising: a sample preparing section for preparing first and second measurement sample including reagent and sample; a first detector for detecting a predetermined component in the first measurement sample prepared by the sample preparing section; a second detector for detecting the predetermined component in the second measurement sample prepared by the sample preparing section; and a controller configured for performing operations, comprising: (a) controlling the first detector to detect the predetermined component in the first measurement sample prepared by the sample preparing section; (b) determining the reliability of the result detected by the first detector; (c) controlling the sample preparing section to prepare the second measurement sample from the same sample when the result has been determined to be unreliable; and (d) controlling the second detector to detect the predetermined component in the second measurement sample, is disclosed.04-29-2010
20100106425SOLID-STATE UREA BIOSENSOR AND ITS DATA ACQUISITION SYSTEM - A data acquisition system for a solid-state urea biosensor uses an amplifier, a low-pass filter and a data acquisition card to acquire and relay data to a computer to be analyzed by a signal analysis program and displayed on a display panel. The biosensor includes a substrate, and three individual sensing areas separated by an insulating layer on the substrate. Each individual sensing area contains a conductive layer on the substrate, and a pH sensitive membrane is deposited thereon. An enzyme layer is deposited on one of the pH sensitive membranes to form a working electrode. The other two sensing areas are a quasi-reference electrode and a contrast electrode, respectively. The signals are transferred to an instrumentation amplifier. The amplified signals are then transferred to a low-pass filter. The filtered signals are analyzed by the program and then displayed on the display panel.04-29-2010
20100106423METHOD AND APPARATUS FOR ASSESSING FEASIBILITY OF PROBES AND BIOMARKERS - The quantitative evaluation of biomarker-probe activity is disclosed. In certain embodiments, the biomarker-probe activity may be quantified and analyzed using biodistributions generated using a model. In some embodiments, such biodistributions may be used to generate simulated images from which quantitative thresholds may be derived. In some embodiments, the quantitative thresholds may be used to analyze the biodistributions.04-29-2010
20100106424Device for Determining the State of a Biological Subject - The invention relates to physics and can be used for determining the functional state of a biological object, for example, a human or an animal.04-29-2010
20090143993Method of Diagnosing the Presence and/or Severity of a Hepatic Pathology in an Individual and/or of Monitoring the Effectiveness of a Treatment for one such Pathology - The invention relates to a method of diagnosing the presence and/or severity of a hepatic pathology and/or of monitoring the effectiveness of a curative treatment against a hepatic pathology in an individual, comprising the establishment of at least one non-invasive diagnostic score, in particular a diagnostic score for portal and septal fibrosis and/or an estimate score for the fibrosis area and/or an estimate score for the fractal dimension.06-04-2009
20120185176Methods for Non-Invasive Prenatal Ploidy Calling - Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus.07-19-2012
20120185175NUTRITION FOR A COMPANION ANIMAL - Determining a nutritional diet for a canine or feline companion animal comprises employing a computer; at least one electronic database coupled to the computer; and at least one software routine executing on the computer. First data comprises a relationship between expression data from the genomic map and a physiological condition of the animal, and second data comprises an effect of nutrition on the expression data from the genomic map. Based on said first and second data, a nutritional diet for the canine or feline companion animal is determined.07-19-2012
20120185174Prognostic Signature for Colorectal Cancer Recurrance - An assay system is useful for predicting recurrence and/or non-recurrence of colorectal cancer in a patient. The assay system is adapted to analyze a patient sample for quantitative expression of a prognostic genetic profile correlated with colorectal cancer recurrence. The profile includes the expression of the nucleic acid sequences of SEQ ID NOS: 1, 2, 3, 4, and 5.07-19-2012
20120185173NEURAL ACTIVITY MEASUREMENT SYSTEM - The present invention provides a neural activity measurement system for measuring the electrical response of a neuron itself to achieve an electrical measurement of the neural activity itself, by providing a stimulator for applying an electrical stimulus to the neuron, as well as a Kelvin probe including a cantilever for detecting the electrical signal propagated through the neuron.07-19-2012
20120185172METHOD, SYSTEM AND APPARATUS FOR DATA PROCESSING - A method, system and apparatus for processing requests is provided. The method comprises storing, in a memory, splicing code data comprising a plurality of features, the splicing code data further comprising, in association with each feature, at least one parameter defining the activity of the feature in splicing regulation; receiving a request at a processor, the request identifying at least a first portion of a genomic sequence; receiving, at the processor, at least a second portion of the genomic sequence that is relevant to the first portion; generating, at the processor, a feature set comprising at least one feature from the second portion of the genomic sequence; generating, based on the splicing code data and the feature set, a response to the request, the response comprising at least one of predicted changes in inclusion levels and a predicted feature map for at least one condition; and transmitting the response.07-19-2012
20090125243Apparatus and method for identifying the original femorotibial joint location in a revision knee replacement - An apparatus and method is disclosed of identifying the original femorotibial joint location in a revision knee replacement of a patient. The invention comprises selecting a first reference point (H) relative to the femoral head of the patient. A second reference point (A) is selected relative to the adductor tubical of the femur of the patient. The femorotibial joint location (J) is calculated through a relationship between the first reference point (H) and the second reference point (A) of the patient. The method and apparatus defines a femur reference plane to assist in establishing the correct rotation of the femur in a revision knee replacement of a patient.05-14-2009
20100094561APPARATUS AND METHOD FOR PROCESSING BIOLOGICAL INFORMATION - A biological information processing apparatus includes the following elements. A light source irradiates biological tissue with light. A transducer functions as an ultrasonic wave transmitting unit that applies an ultrasonic wave to a local region in the biological tissue. A photodetector detects modulated light obtained by modulating the light from the light source with the ultrasonic wave in the local region. The transducer also functions as an acoustic wave detecting unit that detects an acoustic wave emitted from the local region at a time when the local region absorbs the light from the light source. An absorption characteristic in the local region is calculated using an acoustic signal, serving as an output of the acoustic wave detecting unit, on the basis of a light intensity in the local region calculated based on a modulation signal, serving as an output of the photodetector.04-15-2010
20100094562System, Method and Device for Comprehensive Individualized Genetic Information or Genetic Counseling - A method and system for analysis of genetic information. Preferably, such analysis enables genetic counseling to be provided to a patient and/or relative, in which such counseling includes conveying at least one aspect of the analysis in lay terms.04-15-2010
20090265114Influenza virus neuraminidase crystal structure and their use thereof - The invention relates to crystals of the influenza virus neuraminidase protein, their structures and their use.10-22-2009
20100070188Intelligent medical device system for on-demand diagnostics - The system describes the diagnostic procedures involving the intelligent medical device (iMD) system. After data is collected from a patient by using cellular and molecular samples, the device detects and analyzes pathology. The system uses lab on a chip03-18-2010
20130046481Dual-Spectrum Heat Pattern Separation Algorithm For Assessing Chemotherapy Treatment Response And Early Detection - It is developed a Dual-Spectrum Heat Pattern Separation (DS-HPS) algorithm to quantify the energy from the area of the high temperature tissues, called q02-21-2013
20130046480AUTOMATIC ANALYSIS DEVICE AND AUTOMATIC ANALYSIS METHOD - There is provided a technique for automatically determining or predicting a line range specific to a sample that appears in a reaction curve in an automated analyzer for mixing a specimen and a reagent and measuring a change in a mixture of the specimen and the reagent with time. This invention approximates reaction curve data by a function and automatically determines a curve part at an early stage or a second stage of a reaction. The invention determines a line range not including a curve part for each sample and calculates a laboratory test value using absorbance data within the determined line range. This invention also automatically determines a start time of line at the early stage of the reaction on the basis of absorbance data obtained up to a point halfway through the reaction curve, predicts a line range on the basis of the end time of line and a planned end time of line, and calculates a predictive value on the basis of a result of the prediction.02-21-2013
20130046478SYSTEM AND METHOD OF INCREASING SAMPLE THROUGHPUT - Technologies for increasing sample throughput by predicting the end point response time of a sensor for the analysis of an analyte in a sample are disclosed. In one aspect, a system includes a sensor that generates data signals associated with the measurement of an analyte within the sample. A processor records appropriate data points corresponding to the signals, converts them to a logarithmic function of time scale, and plots the converted data points. The processor then determines a curve that fits the plotted data points and determines a curve fitting equation for the curve. Once the equation is determined, the processor extrapolates an end point response of the sensor using the equation. A value, such as analyte concentration, is then calculated using the extrapolated end point response.02-21-2013
20130046477Systematic distillation of status data relating to regimen compliance - Configuration technologies for cost-effectively monitoring indicia of regimen compliance or noncompliance in response to one or more indications of symptoms or actions or other data on data-bearing media or in wireless transmissions, such as implementing techniques for providing or preventing access or otherwise acting on or communicating incremental or definitive indicia of compliance or noncompliance.02-21-2013
20130046479WHOLE CROP BIOFUEL PRODUCTION (WCBP) - A computerized method of using a data processor having a memory to account for carbon flows and determine a regulatory value for a biofuel can include (i) storing, in memory, a first set of one or more carbon flow values characterizing the production and use of a biofuel derived from a first fraction of an agricultural biomass, (ii) storing, in memory, a second set of one or more carbon flow values characterizing the production and use of a co-product from a second fraction of the agricultural biomass, wherein the second fraction comprises an agricultural residue and wherein the co-product mitigates anthropogenic greenhouse gas emission, and (iii) calculating, using the data processor, a regulatory value for the biofuel from the first and second sets of carbon flow values.02-21-2013
20100153018Method for Identifying Genetic Determinants of Transcription Factor Activity - The disclosed subject matter is directed to genetic linkage methods for identifying genetic determinants of transcription factor activity. An inferred transcription factor activity profile is generated based on a nucleotide sequence-specific mathematical model of gene expression regulation. Genetic linkage analysis is performed to identify at least one genetic determinant linked to a specific transcription factor segregant based on the inferred transcription factor profile.06-17-2010
20110202282Multi-Stage Search for Microbe Mass Spectra in Reference Libraries - Microbes in a sample are identified by calculating similarities between a mass spectrum of the sample and reference mass spectra in a spectral library. The spectral library is divided into a hierarchy of sub-libraries where each sub-library contains reference mass spectra of microbes which are statistically the most prevalent in the samples, but are not included in other sub-libraries and all additional reference mass spectra in the library that have substantial similarity to the reference mass spectra of these microbes. Only if the search in a sub-library does not provide a hit with sufficient certainty of identification, is the search carried out in sub-libraries of higher stages.08-18-2011
20090043512Structure-sequence based analysis for identification of conserved regions in proteins - Disclosed are computational methods, and associated hardware and software products for scoring conservation in a protein structure based on a computationally identified family or cluster of protein structures. A method of computationally identifying a family or cluster of protein structures in also disclosed herein.02-12-2009
20110010106APPARATUS STATE DETECTOR, METHOD FOR DETECTING APPARATUS STATE, APPARATUS STATE DETECTION SERVER AND APPARATUS STATE DETECTION SYSTEM; LIVING PERSONS' ANOMALY DETECTOR, LIVING PERSONS' ANOMALY DETECTION SYSTEM AND METHOD FOR DETECTING LIVING PERSONS' ANOMALY, AND APPARATUS-STATE DATABASE MAINTENANCE SERVER - An apparatus state detector and its associates are provided to save time and effort for learning combinations of operation states of all apparatuses at home and commit fewer estimation errors even when an unknown apparatus starts operating. The apparatus state detector includes measuring means 01-13-2011
20100138164PHYSICAL GEOLOCATION SYSTEM - A real-time system for determining the geographic movements of an individual or object by sampling particulates contained thereon. The system includes particle collection, sample preparations, and sample analysis using three primary modes of detecting certain particulates. The first mode involves the imaging of pollen, spores, or other biological material which are visible through a light microscope when properly stained or prepared. The second mode involves the use of real-time polymerase chain reaction to amplify and detect target nucleic acid sequences. The third mode involves the use of X-ray diffraction to identify mineral particles. The results from any mode, or any combination of modes, are analyzed by comparison to a reference database containing geographic information and the results are compiled by a controller for visual display.06-03-2010
20100138162NUCLEIC ACID SEQUENCING SYSTEM AND METHOD USING A SUBSET OF SITES OF A SUBSTRATE - A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected.06-03-2010
20100138163METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR MONITORED APPLICATION OF MECHANICAL FORCE TO SAMPLES USING ACOUSTIC ENERGY AND MECHANICAL PARAMETER VALUE EXTRACTION USING MECHANICAL RESPONSE MODELS - The subject matter described herein includes methods, systems, and computer readable media for monitored application of mechanical force to samples using acoustic energy and mechanical parameter value extraction using mechanical response models. One aspect of the subject matter described herein includes a method for determining mechanical property parameters of a sample. The method includes applying acoustic energy to a sample to apply a mechanical force to the sample. The method further includes measuring a response by the sample during the application of the acoustic energy to determine a value for a first mechanical property parameter of the sample. The method further includes measuring a recovery response of the sample following cessation of the application of the acoustic energy to determine a value for at least one second mechanical property parameter of the sample. The method further includes determining a value for at least one additional mechanical property parameter of the sample based on a mathematical relationship between the first, at least one second, and at least one additional mechanical property parameter.06-03-2010
20100138161METHOD AND SYSTEM FOR ANALYZING DRUG ADVERSE EFFECTS - The system of the present invention for assessing and analyzing the risks of adverse effects resulting from the use of at least one substance of interest, comprises a selector for identifying at least one substance of interest; a profiler for selecting from multiple profiles related to the safety of the at least one substance of interest, using at least one filter; at least one data mining engine; and an output device for displaying the analytic results from the data mining engine. Preferably, the at least one data mining engine is selected from (1) a proportional analysis engine to assess deviations in a set of the reactions to the drug of interest; (2) a comparator to measure the reactions to the drug of interest against a user-defined backdrop, and (3) a correlator to look for correlated signal characteristics in drug/reaction/demographic information; and an output device whereby a user can receive analytic results from the selector, the proportional analysis engine, the comparator, and the correlator.06-03-2010
20100138160Model transition sensitivity analysis system and method - A method and system for analyzing an infectious disease uses computer based simulation engines. The method and system utilizes at least two computer-based simulation engines of the transmission of the infectious disease. The transmission of the infectious disease is analyzed as a function of the first and second computer-based simulation engines.06-03-2010
20100268474METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR PREDICTING RESPONSIVENESS TO A PHARMACEUTICAL THERAPY FOR OBESITY OR EVALUATING INVESTIGATIONAL PHARMACEUTICAL AGENTS - Methods, systems, and computer program products using TRL V6 as a biomarker for the modulation of triglyceride and/or lipoprotein metabolism in a mammal induced by an investigational weight loss pharmaceutical agent. The biomarker may be used for predetermining if an individual patient will likely respond favorably to a given weight loss pharmaceutical agent and/or for testing a pharmaceutical agent's ability to modulate triglyceride and/or lipoprotein metabolism in a mammal.10-21-2010
20100268472DETERMINATION OF SINGLE PEAK MELTING TEMPERATURE BY PCR ANALOGY AND DOUBLE SIGMOID EQUATION - Systems and methods for determining melting temperatures, Tm, for DNA from melt curve data. The systems and methods also allow for quantitative determination of gene amount based on peak height. A PCR analogy is used to perform quantization of an acquired melting curve dataset. The melting curve is transformed using a horizontal flip and a horizontal translation, and a double sigmoid equation is then fit to the data. Inverse translation and inverse horizontal flip transforms are applied to the equation to produce an equation based solution of the melt curve dataset. The equation based solution of the melt curve is then used to determine the first derivative (e.g., Tm value) and peak height.10-21-2010
20090306903COMPOUND SCREENING METHOD AND APPARATUS - A screening apparatus divides measurement data representing the amount of binding between one kind of protein and each of a plurality of kinds of compounds, obtained by a measurement apparatus, into groups, each including data obtained in a same measurement condition. The screening apparatus obtains a representative value of measurement data that is obtained when the protein and a compound are not bound to each other for each of the groups by using the measurement data belonging to the respective groups, and sets a threshold value for extracting a hit compound for each of the groups by using corrected measurement data, obtained by correcting the measurement data for each of the groups so that the representative value obtained for each of the groups becomes the same value. Then, a hit compound is extracted by comparing the threshold value with the corrected measurement data.12-10-2009
20090306902Screening Method - A method for structure-based virtual screening, wherein compounds for investigation are categorized or sorted into a catalog according to their physicochemical and steric properties. The physicochemical and steric properties of a target are determined, the part(s) of the catalog which match the determined properties of the target are determined, and only the compounds in these parts of the catalog are screened against the target.12-10-2009
20090306901SYSTEM AND METHOD FOR ABSOLUTE QUANTITATION OF PROTEINS USING LC/MS - Absolute quantitation of protein in a sample is provided by comparing a sum or average of the N highest ionization intensities observed for peptides of a particular protein along with a calibration standard. The calibration standard can be in the form of a table generated by prior protein peptide analysis performed using one or more pre-determined proteins. The comparison is used to determine a corresponding absolute quantity of protein based on the observed sum or average of ionization intensities. A simple conversion factor can be applied to the calibration standard value to determine the absolute quantity of protein in the sample.12-10-2009
20090055099Proteomic analysis of biological fluids - The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and maturation. In particular, the invention concerns the identification of the proteome of amniotic fluid (multiple proteins representing the composition of amniotic fluid) and the correlation of characteristic changes in the normal proteome with various pathologic maternal/fetal conditions, such as intra-amniotic infection, or chromosomal defects.02-26-2009
20120191365AUXILIARY DIAGNOSTIC APPARATUS AND AUXILIARY DIAGNOSTIC METHOD - Disclosed is an auxiliary diagnostic apparatus including: a vector input unit that reads a test vector which is a spectral property vector of a biological tissue targeted for a diagnosis; a multiple linear regression analysis unit that executes a multiple liner regression analysis for the test vector with a plurality of individual component vectors which are spectral property vectors of particular substances, and obtains an error vector which is a vector of a residual error component; and an indicator calculation unit that extracts a feature of the error vector, and, from the extracted error vector, calculates an indicator representing whether an affected area is included in the biological tissue targeted for the diagnosis and which type of affected area has a possibility of being included in the biological tissue.07-26-2012
20120191364METHODS AND ARRAYS FOR DNA SEQUENCING - A method of sequencing a first polynucleotide strand having a first polynucleotide sequence, the first polynucleotide strand resembling a second polynucleotide strand having a known second polynucleotide sequence, the method employing a data set which, for one or more fragment(s) of the second polynucleotide sequence, contains: for each position along each said fragment: (i) first probe data describing the hybridization intensity of the first polynucleotide strand with a respective first probe designed to bind to a portion of the second polynucleotide strand centered at said position; and (ii) second probe data describing the respective hybridization intensities of the first polynucleotide strand with each of a set of second probes, each said second probe being designed to bind with a respective mutation of the corresponding portion of the second polynucleotide sequence which is formed by mutating the corresponding portion of the second polynucleotide sequence at said position, the data set including said second probe data for every possible said mutation; the method comprising: for each said position, obtaining from the dataset a first numerical parameter characterizing the hybridization intensity of the first polynucleotide strand with the corresponding first probe in comparison to the hybridization intensities of the first polynucleotide strand with the corresponding second probes; said first numerical parameter being indicative of whether a nucleic acid of the first polynucleotide sequence is equal to a nucleic acid the second polynucleotide sequence at said position.07-26-2012
20120191363Reagents, Methods, and Libraries for Bead-Based Sequencing - The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension probes containing phosphorothiolate linkages and employ agents appropriate to cleave such linkages. The invention provides methods of determining information about a sequence using at least two distinguishably labeled probe families. In certain embodiments the methods acquire less than 2 bits of information from each of a plurality of nucleotides in the template in each cycle. In certain embodiments the sequencing reactions are performed on templates attached to immobilized beads. The invention further provides sets of labeled extension probes containing phosphorothiolate linkages. In addition, the invention includes performing multiple sequencing reactions on a single template by removing initializing oligonucleotides and extended strands and performing subsequent reactions using different initializing oligonucleotides.07-26-2012
20120191362CALIBRATION METHOD FOR THE PROSPECTIVE CALIBRATION OF MEASURING EQUIPMENT - A method for operating measuring equipment for detecting an analyte in a bodily fluid by means of a continuously measuring blood glucose sensor. A calibration method is carried out for the prospective calibration of the measuring equipment. At least three calibration points are detected in the calibration method, wherein each calibration point comprises a measurement signal from the measuring equipment and a reference value of an associated reference measurement. A plurality of possible slopes are established between the calibration points. At least one robust estimation method, using a formation of at least one median is used to determine a probable slope from the plurality of possible slopes. Furthermore, a measurement is carried out. During the measurement and using the probable slope, a concentration of the analyte in the bodily fluid is deduced from a measurement signal from the measuring equipment and the probable slope.07-26-2012
20120191361Tracking the Probability for Imminent Hypoglycemia in Diabetes From Self-Monitoring Blood Glucose (SMBG) Data - A method, system and related computer program product for tracking the probability of hypoglycemia from routine self-monitoring of blood glucose (SMBG) data in patients with diabetes. A specific bivariate probability distribution of low BG events based jointly on the Low BG Index (LBGI) and the Average Daily Risk Range (ADRR) is used to predict hypoglycemia probability of occurrence from inputted SMBG data. The SMBG data is retrieved from a series of SMBG data of a patient available from the patient's glucose meter and allows tracking of the probability for future hypoglycemia over a predetermined duration, e.g., a 07-26-2012
20120191360CSF biomarker dilution factor corrections by MRI imaging and algorithm - A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated measurements of the ventricular system by MRI scans using quantitative anatomical protocols, determining a measurement of biomarker levels in CSF that has been extracted, correcting the measurement of the level of said at least one biomarker'according to the ventricular size, and providing a corrected result of the measurement determined in step (b), said corrected result accounting for concentration dilution due to the change in ventricular size. The method is particularly suited for the measurement of all biomarkers found in the CSF, such as those associated with mild cognitive impairment (MCI) and Alzheimer's Disease.07-26-2012
20120191357Discovering Progression and Differentiation Hierarchy From Multidimensional Data - Methods and systems for determining progression and other characteristics of microarray expression levels and similar information, alternatively using a network or communications medium or tangible storage medium or logic processor.07-26-2012
20120191356Assembly Error Detection - A method for detecting errors in genetic sequence assemblies including defining an assembly (A) of a sequence of genetic data, collecting read data into a library of reads (L), plotting histograms of sizes or reads versus a number of reads per size, normalizing a distribution (D) with a coverage C to obtain D′ that has a mean (μ) and standard deviation (σ) and reserve positions (i) not used to obtain D′, collecting subset of reads (S07-26-2012
20120191355Insect Prediction Techniques for the Forestry Industry - A study of the tip moth-pine tree interaction reveals clues as to the moments when the pine trees are most likely to be damaged by tip moths. From this study, software tools may be extrapolated which help farmers know when to apply pesticides to limit damage to the pine crop and also educational software so student-farmers may know more about the life-cycle of the crop and threats to the crop. While originally focused on the pine tree-tip moth dynamic, the study is readily abstracted for use with other crop-insect dynamics.07-26-2012
20090093967GENOME ANALYSIS SYSTEM II - The present invention provides that the analysis can be estimated the characteristics of the originated populations which belong to the samples and the characteristics of the samples from sample data. By loading the sample data, by interfering with the second state variable showing the characteristics in the environment system to the first state variable showing the characteristics in the objective system, by converging the variable by selecting the maximum resonant state, and by estimating the characteristics of the samples and the characteristics of the originated populations which belong to the samples, then the result estimated the characteristics of the originated populations is outputted.04-09-2009
20090006001EMPIRICAL QUANTITATIVE APPROACHES FOR PSYCHIATRIC DISORDERS PHENOTYPES - Psychiatric phenotypes as currently defined are primarily the result of clinical consensus criteria rather than empirical research. A novel approach to characterizing psychiatric phenotypes is presented herein, termed PhenoChipping. A massive parallel profiling of cognitive and affective state is done with a PhenoChip composed of a battery of existing and new quantitative psychiatric rating scales, as well as hand neuromotor measures. Phenotypic overlap among, as well as phenotypic heterogeneity within, the three major psychotic disorders studied were demonstrated. Empirically derived clusterings of (endo)phenotypes and of patients serve genetic, pharmacological, and imaging research, as well as clinical practice.01-01-2009
20130073215Heart Age Assessment - An automated method of determining a measure of a subject's heart age comprising the steps of: prompting a user for a plurality of inputs, each relating to an attribute of the subject, each attribute defining one or more of a demographic status of the subject, a lifestyle status of the subject, a physical condition of the subject and a medical history of the subject: receiving, from the user, a plurality of said inputs: determining from said received inputs, a set of parameters for which input data has been received as input from the user; selecting a heart age calculation algorithm from a predetermined set of heart age calculation algorithms according to said set of parameters; and calculating a heart age for the subject according to the selected algorithm; and providing as output said calculated heart age.03-21-2013
20130073214SYSTEMS AND METHODS FOR IDENTIFYING SEQUENCE VARIATION - Systems and method for determining variants can receive mapped reads, and call variants. In embodiments, flow space information for the reads can be aligned to a flow space representation of a corresponding portion of the reference. Reads spanning a position with a potential variant can be grouped and a score can be calculated for the variant. Based on the scores, a list of probable variants can be provided. In various embodiments, low frequency variants can be identified where multiple potential variants are present at a position.03-21-2013
20130073213Gene Expression-Based Differential Diagnostic Model for Rheumatoid Arthritis - Biomarkers useful for differential diagnosis for rheumatoid arthritis from samples of peripheral blood mononuclear cells are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples.03-21-2013
20130073212DETECTION OF RISK OF PRE-ECLAMPSIA - A method for the early prediction of risk of hypertensive disorders in pregnant women, including for example eclampsia, mild pre-eclampsia, chronic hypertension, EPH gestosis, gestational hypertension, superimposed pre-eclampsia, HELLP syndrome, or nephropathy.03-21-2013
20130073211MICROCONTROLLER BASED PEDIATRIC DEVICE AND METHOD OF NOURISHMENT EVALUATION - A microcontroller based breast milk flow meter and child milk volume intake detection and measuring method means comprising a silicone encapsulated flexible microcontroller circuit means with a plurality of on-board dielectric detector plate means and a piezo-resistive force sensor means. Where the dielectric detector plates function electrically, as a passive device means to determine the presence or absence of a quantity of milk in a holding chamber means and a piezo-resistive force sensor function electrically, as a passive device means to determine a continuous or sporadic flow quantity of milk from said chamber means. A special microcontroller algorithm is used to monitor, detect, and measure breast milk flow and quantity from mother to child.03-21-2013
20130060477SYSTEMS AND METHODS FOR TOPOGRAPHIC ANALYSIS - The systems and methods described herein provide a scientific and analytical basis for the following: (a) collective interpretation of the entire spectrum of chromatographic data, e.g., GC×GC two-dimensional data, with capability of operating at multi-resolution over bigger or smaller sub-regions of the two-dimensional data, (b) given two or more samples that are from the same source, and some samples from clearly different sources, quantitatively estimate where the fingerprint of the source lies, (c) given a source signature template, an unknown sample can be compared to decide whether it is related to, and if so, to what degree, to this source, and (d) given two source signature templates, the templates can be compared to determine how related is one source to the other.03-07-2013
20110015869METHODS AND GENE EXPRESSION SIGNATURE FOR ASSESSING GROWTH FACTOR SIGNALING PATHWAY REGULATION STATUS - Methods, biomarkers, and expression signatures are disclosed for assessing the regulation status of growth factor pathway signaling in a cell sample or subject. More specifically, several aspects of the invention provide a set of genes which can be used as biomarkers and gene signatures for evaluating growth factor pathway deregulation status in a sample; classifying a cell sample as having a deregulated or regulated growth factor signaling pathway; determining whether an agent modulates the growth factor signaling pathway in sample; predicting response of a subject to an agent that modulates the growth factor signaling pathway; assigning treatment to a subject; and predicting evaluating the pharmacodynamic effects of cancer therapies designed to regulate growth factor pathway signaling.01-20-2011
20110015868METHOD AND APPARATUS FOR WAVEFORM ANALYSIS OF PHYSIOLOGICAL PARAMETERS - A method and an apparatus are provided for performing waveform analysis on physiological parameters. In one embodiment, a method includes reading measurement values of a first physiological parameter relating to time, and displaying them as a trend display graph in a trend display area that includes first coordinates representing time and second coordinates representing the measurement values. The method also includes acquiring a time selected in the trend display graph, and displaying, in a waveform display area, waveform data of a second physiological parameter associated with formation of the first physiological parameter during periods before and after the selected time. The waveform display area includes time coordinates. The disclosed embodiments allow medical staff to view the curve of a patient's physiological parameters throughout a monitoring/therapy period. Medical staff may make a detailed analysis of the waveform data in real time, which may provide a basis for making decisions in the following therapy processes.01-20-2011
20110015867METHOD FOR REDESIGN OF MICROBIAL PRODUCTION SYSTEMS - A computer-assisted method for identifying functionalities to add to an organism-specific metabolic network to enable a desired biotransformation in a host includes accessing reactions from a universal database to provide stoichiometric balance, identifying at least one stoichiometrically balanced pathway at least partially based on the reactions and a substrate to minimize a number of non-native functionalities in the production host, and incorporating the at least one stoichiometrically balanced pathway into the host to provide the desired biotransformation. A representation of the metabolic network as modified can be stored.01-20-2011
20110015866Active Interface Device - An active interface device including a transducer or sensor array having a plurality of transducers or sensors arranged to transform a cell activity into an electrical signal, at least one detection unit for detecting the electrical signal(s), at least one recording unit for recording the electrical signal(s), comprising a plurality of recording channels arranged for being routed to the transducers or sensors, and at least one control unit. The control unit is arranged for addressing the transducers or sensors to the detection unit(s), for activating transducers or sensors, and for routing the recording channels to activated transducers or sensors.01-20-2011
20110015865DETERMINATION OF CORONARY ARTERY DISEASE RISK - Markers and methods useful for assessing coronary artery disease in a subject are provided, along with kits for measuring their expression. Also provided are predictive models, based on the markers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples.01-20-2011
20110015864OLIGOMER SEQUENCES MAPPING - Mapping oligomer sequences includes receiving a set of related oligomer sequences, applying one or more key patterns derived from a set of oligomer sequence relationships to obtain one or more keys that are consistent with the set of related oligomer sequences, modifying positions within these keys, and locating the one or more keys in an index configured to map a plurality of candidate and/or validated keys to their respective possible and/or validated locations in a reference.01-20-2011
20110015863METHOD FOR IDENTIFICATION AND SEQUENCING OF PROTEINS - Protein samples are processed to create a mixture of modified and unmodified or overlapping peptides which are analyzed using mass spectrometry. Correlations between the MS/MS spectra of peptide pairs allow the noise in individual MS/MS spectra to be greatly reduced. A small number of peptide reconstructions can be generated that are likely to contain the correct one. This allows for the de novo reconstruction of protein sequences and peptide and modification identification through a database search using extremely fast pattern matching, rather than time-consuming matching of spectra against databases.01-20-2011
20130060480METHOD AND APPARATUS FOR PROVIDING ADAPTIVE DISPLAY AND FILTERING OF SENSORS AND SENSOR DATA - An approach is provided for adaptive display and filtering of sensors and sensor data. A sensor manager determines one or more signals associated with one or more sensors. The sensor manager then processes and/or facilitates a processing of the one or more signals for comparison against one or more predetermined signals. The sensor manager determines one or more parameters for one or more filters based, at least in part, on the comparison, wherein the one or more filters operate, at least in part, on the one or more sensors, one or more other signals determined form the one or more sensors, or a combination thereof.03-07-2013
20130060479METHOD AND SYSTEM FOR GENOTYPING SAMPLES IN A NORMALIZED ALLELIC SPACE - Aspects of the present invention describe an apparatus and method for generating genotype calls for a sample. The genotyping initially models allelic signal response into an allelic model having one or more model parameters for an identified one or more sources of systematic variation. The model and parameters are then used to transform the allelic signals to a normalized normalized allelic space that serves to compensate for the one or more sources of systematic variation. By compensating for the systematic variation in this manner, the genotype for the sample is readily determined based upon its relationship to the representation of the allelic signals in normalized allelic space and in accordance with the allelic model.03-07-2013
20130060478VOLTAGE OFFSET CORRECTION IN HIGH-THROUGHPUT ELECTROPHYSIOLOGICAL MEASUREMENT SYSTEM - A computer-implemented method for controlling command voltages applied to electrodes during an electrophysiology measurement procedure using a high-throughput measurement system is provided. An initial command voltage is applied to the electrodes to obtain baseline currents respectively associated with the electrodes. A common offset voltage is determined based on the baseline currents, and an adjusted command voltage is determined based on the initial command voltage and the common offset voltage. The adjusted command voltage is applied to at least one of the electrodes to obtain an adjusted current measured by the electrode. A local offset voltage for the electrode is determined based on the adjusted current measured by the electrode. A subsequent command voltage applied to the electrode incorporates the common offset voltage and the local offset voltage.03-07-2013
20120310542METHOD FOR DETERMINING A PARAMETER REPRESENTATIVE OF THE STATE OF VIGILANCE OF A VEHICLE DRIVER - A method for determining a parameter representative of the state of vigilance of a vehicle driver, from the measurement of the steering wheel angle of the vehicle includes determining two successive ranges of temporal windows: a first range of temporal windows T(t12-06-2012
20120310541ONLINE DETERMINATION OF INTER ALIA FAT, PROTEIN, LACTOSE, SOMATIC CELL COUNT AND UREA IN MILK BY DIELECTRIC SPECTROSCOPY BETWEEN 0.3 MHZ AND 1.4 GHZ USING CHEMOMETRIC EVALUATION - A method for determining a concentration of at least one component of milk includes measuring impedance values between two electrodes associated with a cell containing a milk sample at each of at least three frequencies, and estimating a concentration of the at least one component from a polynomial expression in which the impedance values at the at least three frequencies are variables. A system for determining a concentration of at least one component of milk includes a sampling cell including a milk sample, electrodes operative to electrify the milk sample with excitation signals at a plurality of frequencies including at least three frequencies, a signal generator for generating the excitation signals, circuitry for determining a relationship between an amplitude and phase of reflected and incident signals obtained from the signal generator, and a processor that receives the relative amplitude and phase and estimates a concentration of at least one component of milk based on a polynomial expression relating measured impedance values at a plurality of frequencies to concentrations of at least one component of milk.12-06-2012
20120310539PREDICTING GENE VARIANT PATHOGENICITY - A computer-implemented, gene-specific prediction tool for classifying and interpreting gene tests is described. The prediction tool includes a predictor using a consensus framework. The predictor employs a weighted metric of existing and complementary prediction algorithms and calculated reference intervals of disease outcomes to calculate a consensus score used in interpreting gene tests.12-06-2012
20090276161Heart age assessment - An automated method of determining a measure of a subject's heart age comprising the steps of: prompting a user for a plurality of inputs, each relating to an attribute of the subject, each attribute defining one or more of a demographic status of the subject, a lifestyle status of the subject, a physical condition of the subject and a medical history of the subject; receiving, from the user, a plurality of said inputs; determining from said received inputs, a set of parameters for which input data has been received as input from the user; selecting a heart age calculation algorithm from a predetermined set of heart age calculation algorithms according to said set of parameters; and calculating a heart age for the subject according to the selected algorithm; and providing as output said calculated heart age.11-05-2009
20090132171Screening Method for Specific Protein in Proteome Comprehensive Analysis - A screening method for a specific protein in a proteome analysis comprises: (a) obtaining samples containing a protein or protein digest from a cell or tissue in a specific group and a control group; (b) analyzing the samples obtained in the step (a) with a mass spectrometer, thereby obtaining mass spectrometry data; (c) analyzing the mass spectrometry data obtained in the step (b) using an arbitrary database searching software, thereby acquiring a protein list containing items for specifying proteins and indexes for identifying the proteins, for each of the samples; (d) averaging values of the indexes for each of the items in all of the protein lists acquired in the step (c), and acquiring protein list models of the specific group and the control group, containing the average values of the indexes; (e) calculating a difference between the average values for each of the items, between the protein list models of the specific group and the control group obtained in the step (d), and acquiring one protein list in which the items are rearranged in the order of the difference between the average values; and (f) selecting a protein with a large difference between the average values, from the protein list acquired in the step (e).05-21-2009
20130096840SEIZURE DETECTION METHODS, APPARATUS, AND SYSTEMS USING AN AUTOREGRESSION ALGORITHM - A method, comprising receiving a time series of patient body signal, determining first and second sliding time windows for the time series; applying an autoregression algorithm, comprising: applying an autoregression analysis to each of the first and second windows, yielding autoregression coefficients and a residual variance for each window; estimating a parameter vector for each window based on the autoregression coefficients and residual variances; and determining a difference between the parameter vectors; and determining seizure onset and seizure termination based on the difference between the parameter vectors. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.04-18-2013
20090271124DIABETES-RELATED BIOMARKERS AND METHODS OF USE THEREOF - The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes.10-29-2009
20090271122Methods and systems for monitoring and modifying a combination treatment - Methods, computer program products, and systems are described that include monitoring at least one attribute of an individual during an artificial sensory experience while the individual is under the influence of a bioactive agent, identifying at least one characteristic of the artificial sensory experience that is proximate to a desired change in the at least one attribute of the individual, and/or modifying at least one of the artificial sensory experience or the bioactive agent at least partly based on the identifying at least one characteristic of the artificial sensory experience that is proximate to the desired change in the at least one attribute of the individual.10-29-2009
20090271121Methods and systems for detecting a bioactive agent effect - Methods, computer program products, and systems are described that include accepting at least one indication of bioactive agent use by an individual and/or presenting an indication of an artificial sensory experience programmed to detect at least one effect of the bioactive agent at least partly based on the at least one indication of the bioactive agent.10-29-2009
20090271120Methods and systems for monitoring bioactive agent use - Methods, computer program products, and systems are described that include accepting at least one indication of a bioactive agent use by an individual and/or assigning an artificial sensory experience to monitor at least one desired effect of the bioactive agent on the individual.10-29-2009
20090271119Pertioneal Membrane Function Test Method, Peritoneal Membrane Function Test Apparatus and Peritoneal Membrane Function Test Program - It is intended to provide a method whereby the peritoneal function of a dialysis patient can be tested by a relatively easy procedure and yet a high accuracy can be achieved compared with the existing methods, and an apparatus for the peritoneal function test by using the same. Standards of four kinetic parameters (CCr, Kt/V, MTACu, and MTACc) available in a definite dialysis guideline are computed in accordance with the relational expression (formula (7)). The curve showing the relation between MTACu/c thus obtained and the drained fluid volume is indicated in a graph together with the PET data of the patient which has been prepared separately. Thus, the peritoneal function can be evaluated based on the relative position of the patient's data and the curve showing the standard values in the graph.10-29-2009
20090271123ORDERING GENES BY ANALYSIS OF EXPRESSION KINETICS - A method for analyzing the temporal behavior of gene expression for a group of genes which are part of a biological system or subsystem. Preferably, such an analysis enables the order of expression of such genes to be determined. More preferably, the temporal behavior of gene expression is assessed according to the analysis of the kinetics of gene transcription. According to a preferred embodiment of the present invention, the kinetics of gene transcription are measured according to promoter activity of a plurality of genes. More preferably, such kinetics are measured in a living organism or a portion of such an organism, such as a cell for example. For single-celled organisms, such as bacteria for example, the kinetics may easily be measured for the entirety of the living organism.10-29-2009
20110046894METHOD FOR DISCRIMINATING BETWEEN MALIGNANT AND BENIGN TISSUE LESIONS - An embodiment of the present invention includes a method for discriminating between benign and malignant tissue lesions. The method includes the steps of using a plurality of maps of physiology and morphology parameters generated from reflectance measurements and pure morphology parameters generated from reflectance measurements. The method also includes calculating entropies and cross entropies of the plurality of maps, and calculating a plurality of pure morphology parameters. Further, the method includes assigning a weight to each entropy and a weight to a logarithm of each entropy, a weight to each cross entropy and a weight to a logarithm of each cross entropy, and a weight to each pure morphology parameter and a weight to a logarithm of each pure morphoiogy parameter. The method further includes computing a diagnostic index, defining a cost function, defining a proper threshold value for a diagnostic index and solving an optimization problem to determine a set of weights from the assigned weights to maximize specificity for 100% sensitivity. Further, the method uses calculations, the cost function and the diagnostic index to determine whether the tissue lesion is benign or malignant.02-24-2011
20110046892Method and Device for Utilizing Analyte Levels to Assist in the Treatment of Diabetes - A health-monitoring device assesses the health of a user based on levels of two analytes in a biological fluid. A first analyte that is utilized to assess a user's health is a fat metabolism analyte, such as ketones, free fatty acids and glycerol, which is indicative of fat metabolism. A second analyte that is utilized is a glucose metabolism analyte, such as glucose. The levels of the two analytes may be used to assess insulin sensitivity, to detect both recent hypoglycemia and the cause of high glucose levels, and/or to guide therapeutic intervention. The dual analyte model may calculate a discrepancy between an actual insulin activity level and a theoretical insulin activity level. The dual analyte model of the present invention may be used to identify individuals at risk for metabolic syndrome, insulin resistance and non-insulin dependent diabetes, and allows monitoring of the progression of those disease states, as well as progress made by therapeutic interventions.02-24-2011
20130166220TOOTHBRUSH USAGE MONITORING - The invention provides a system suitable for monitoring the usage of a toothbrush, the system comprising: (a) a toothbrush; (b) a sound sensor which is located in or on the toothbrush; (c) a programmable data logger which is located in or on the toothbrush, the data logger incorporating a motion sensor and a data store for the logging of data; (d) switching means for triggering the operation of the sound sensor in response to initial signals of toothbrush motion generated by the motion sensor, and (e) a data analysis device which is adapted to analyse data transmitted or acquired from the system to provide information about tooth brushing behaviour; in which the duration of data logging is controllable in response to the combined signals received from the sound sensor and the motion sensor respectively.06-27-2013
20090030619VEHICULAR USER HOSPITALITY SYSTEM - A vehicular user hospitality system recognizes a situation concerning vehicle use according to a combination of a disturbance stimulation type and hospitality intention category. With an intention estimation table, the system determines a reference intention parameter value for providing an intensity reference of a hospitality intention for each of safety, convenience, and comfort categories. The system settles an intention intensity reference using a reference intention parameter value specific to each situation. The system supplements the reference intention parameter value with the current disturbance stimulation value to determine an intention intensity parameter value to be appropriately used as a function selection reference value while considering a disturbance stimulation magnitude. Using a function specification table, function specification information for specifying a function of a hospitality operating portion is extracted according to a combination of the disturbance stimulation type and the hospitality intention category to thereby determine a control content.01-29-2009
20090030618SYSTEM, METHOD AND SOFTWARE ARRANGEMENT FOR ANALYZING AND CORRELATING MOLECULAR PROFILES ASSOCIATED WITH ANATOMICAL STRUCTURES - A system, method and software arrangement according to exemplary embodiments of the present invention are provided which can use molecular profiles obtained from unaltered human tissue specimens for clinical purposes including disease diagnoses and treatment evaluations. For example, spatial distributions of chemical species including metabolites within the tissue may be obtained using radiological techniques such as magnetic resonance spectroscopy imaging. Disease-specific profiles may be obtained by comparing the distributions of chemical species obtained in ex vivo tissues with pathological observations made on them using statistical analysis. The disease-specific profiles may then be correlated with in vivo or ex vivo molecular profiles to obtain spatial maps that can provide a more sensitive and accurate detection of diseased tissue. Thus, such exemplary systems, methods and software arrangements can include the ability to receive information relating to the distribution of at least three chemical species in the tissue of interest, compare this information statistically to a predetermined profile and, based on the statistical correlation between the information and the profile, determine certain characteristics of the tissue of interest such as, e.g., the presence or absence of diseased tissue.01-29-2009
20090030617Biosensor Calibration System - A biosensor system determines an analyte concentration using one or more calibrated correlation equations for an optical and/or electrochemical analysis of a biological fluid. The biosensor system may be implemented using a measurement device and a sensor strip. The measurement device senses circuit patterns on an encoding pattern of the sensor strip. The measurement device determines calibration information in response to the circuit patterns, and uses the calibration information to calibrate one or more of the correlation equations. The measurement device uses the calibrated correlation equations to determine the analyte concentration.01-29-2009
20130066563DISTRIBUTED NETWORK OF IN-VITRO DIAGNOSTIC DEVICES - A system is disclosed in which a plurality of in-vitro diagnostic (IVD) devices each include a network communication device for connecting to a publicly accessible data network. For example, IVD devices are provided with a cellular modern for connecting to a public cellular network. These IVD devices connect to the data network upon completion of a diagnostic test, and upload results of the test, as well as other appropriate data, to a remote device which is also on the network. The IVD devices also download appropriate data from remote network elements. The remote network element may be a network element such as a Hospital Information System (HIS) or Laboratory Information System (LIS) database. Alternatively, the remote device may be a remote server or another IVD device. This connectivity enables the system to accumulate diagnostic test data, and to analyze, report, and/or update the IVD devices based on the accumulated data.03-14-2013
20130066562IN-VITRO DIAGNOSTIC DEVICE USING EXTERNAL INFORMATION IN CONJUNCTION WITH TEST RESULTS - A system and method for augmenting or adding to the information used by an in-vitro diagnostic or other diagnostic device to generate results of a test is disclosed. A diagnostic device is capable of generating test results based on a sample, such as a sample provided by a patient, and is also capable of receiving additional information to enhance the results providable by the device. For example, an in-vitro diagnostic device is configured to read a lateral flow assay test, and is configured to receive additional diagnostic, network, test identification, or environmental information over a network. Using both the result of the diagnostic test and the additional information, the disclosed device provides more thorough, accurate, and reliable diagnostic information. The results generated by the device may be communicated to an appropriate remote device to enhance the results obtainable by such tests.03-14-2013
20110022330 MONITORING APPARATUS - A monitoring system is disclosed which includes at least one experiment node at which, in use of the system, a user participates in a study, and a control node. The experiment node includes communication devices operable to communicate with the user, a user input operable to record the response of a user to a prompt, a user interaction device operable such that the user can interact with the experiment node, and a device to record data relating to such user interactions. The control node is remote from the experiment node and in communication therewith to receive information including user responses and recorded user interaction data therefrom. The control node is also operable to configure the at least one experiment node to execute a plurality of human factors tests on the participant at predetermined times. The monitoring apparatus also includes a co-ordination device operable to co-ordinate the information with the predetermined times.01-27-2011
20110022329Method and Apparatus For Determining Seed Germination - A method is provided for determining the rate of seed germination including the steps of (a) irradiating a selected number or quantity of seeds with light from an NIR spectrometer which is combined with or coupled to a pre-defined calibration model, wherein the light reflects to a detector; (b) collecting the reflected light from the detector; (c) converting the reflected light to an NIR spectrum; and (d) determining the rate of germination using the NIR spectrum obtained and the calibration model. Also provided is a cup for use with an NIR spectrometer including a rotating cylindrical member for receiving a selected number or quantity of seeds coupled to a transparent base through which NIR light is irradiated.01-27-2011
20110022328Methods And Devices For Analyzing Material Properties And Detecting Objects In Scattering Media - Disclosed is a method for determining an phase spectrum θ(ω) of the complex spectral transfer function H(ω) of a medium. In some embodiments, the method is applied for detecting or imaging an object screened by scattering medium or for determining a refractive index spectrum of a material.01-27-2011
20110022327URINE WORK AREA MANAGER FOR A URINE WORK AREA - A urine work area manager comprises a computing unit and a set of machine executable instructions stored in a memory for execution by the computing unit. The computing unit transfers commands and data between a urine test strip reader and the manager using a first interface, and transfers commands and data between a urine sediment analyzer and the manager using a second interface. In operation, the computing unit instructs the urine test strip reader to analyze a plurality of urine samples, receives a strip analysis result from the urine test strip reader, and generates a first set of instructions for controlling the urine sediment analyzer using the strip analysis result. The computing unit further instructs the urine sediment analyzer to analyze the plurality of urine samples with the first set of instructions and receives a sediment analysis result from the urine sediment analyzer using the second interface.01-27-2011
20110022326Quantitation Method Using Isotope Labeled Internal Standard Substance, Analysis System for Executing the Quantitation Method, and Program for the Analysis - Problem: An object of the present invention is to quantitate with good accuracy, furthermore, quantitate absolutely, one or a plurality of biological molecules in a sample such as a tissue, a biological fluid, a cell, a cell organ or protein complex.01-27-2011
20110022325Methods and Apparatus for Measuring the Contents of a Search Volume - A method of measuring the contents of a search volume. The method includes: energising one or more transmitters so as to transmit electromagnetic wave energy into the search volume; detecting the effect of the search volume on the passage of the electromagnetic wave energy by recording two or more signals, each signal being associated with a different propagation path (typically either a monostatic or bistatic path) within the search volume; aligning the signals in order to generate two or more aligned signals which are synthetically focused on a desired voxel in the search volume, each aligned signal being associated with a different propagation path (typically either a monostatic or bistatic path) within the search volume; calculating a quality factor by processing the aligned signals to generate two or more data values, and processing the data values to generate a quality factor, the quality factor being indicative of a degree of coherence in the aligned signals; summing the aligned signals to generate a summed signal; and processing the summed signal to generate an output which is indicative of the internal structure of the search volume at the location of the desired voxel, the output varying in accordance with the quality factor.01-27-2011
20120116684SUPPORTING THE MONITORING OF A PHYSICAL ACTIVITY - Improved techniques and systems for utilizing a portable electronic device to monitor, process, present and manage data captured by a remote sensor during a physical activity session are disclosed. The portable electronic device offers a convenient user interface that can be visual and/or audio based customized to a particular application, user-friendly and/or dynamic. The portable electronic device can pertain to a personal media device and thus also provide media playback.05-10-2012
20120116683HIGHLY SELECTIVE CHEMICAL AND BIOLOGICAL SENSORS - Methods and sensors for selective fluid sensing are provided. Each sensor includes a resonant inductor-capacitor-resistor (LCR) sensor that is coated with a sensing material. In order to collect data, an impedance spectrum is acquired over a relatively narrow frequency range, such as the resonant frequency range of the LCR circuit. A multivariate signature may be calculated from the acquired spectrum to discern the presence of certain fluids and/or fluid mixtures. The presence of fluids is detected by measuring the changes in dielectric, dimensional, resistance, charge transfer, and other changes in the properties of the materials employed by observing the changes in the resonant electronic properties of the circuit. By using a mathematical procedure, such as principal components analysis (PCA) and others, multiple fluids and mixtures can be detected in the presence of one another, even in a high humidity environment or an environment wherein one or more fluids has a substantially higher concentration (e.g. 10×, 1,000,000×) compared to other components in the mixture.05-10-2012
20090037116SYSTEMS, DEVICES, AND METHODS FOR ANALYZING MACROMOLECULES, BIOMOLECULES, AND THE LIKE - Systems, devices, and methods for analyzing hybridization of target molecules to probes on substrate-bound oligonucleotide, peptide, or protein arrays. In one aspect, the system includes a computer-readable memory medium and a controller. The system may further include a computer-readable memory medium including thermodynamic data configured as a data structure for use in analyzing biological samples. In some embodiments, the data structure comprises a thermodynamic data section having: thermodynamic data representative of dangling ends of two or more bases; thermodynamic data representative of unpaired single strands of two or more bases adjacent to a Watson-Crick base pairing; thermodynamic data representative of unpaired single strands of one or more bases adjacent to a non-Watson-Crick base pairing; thermodynamic data representative of tandem base pair mismatches of two or more bases; thermodynamic data representative of length-dependent terminal mismatches of nucleic acid bases; thermodynamic data representative of terminal base pair mismatches, or combinations thereof.02-05-2009
20110270528Method for Random Grouping of Multiple Parameters - A method is provided for randomizing at least two factors among subjects, comprising (a) measuring said at least two factors in said subjects; (b) creating candidate solutions comprising said subjects; (c) evaluating fitness of said candidate solution; (d) forming a new generation from candidate solutions; and (d) repeating steps (c) and (d) to obtain a candidate solution with optimal fitness.11-03-2011
20090012718Nuclear Medicine Diagnosis Apparatus and Diagnostic System Used Thereto - The function of an accumulated amount deriving part 01-08-2009
20090012717Method For Determining Drug-Molecular Combinations That Modulate And Enhance The Therapeutic Safety And Efficacy Of Biological Or Pharmaceutical Drugs - A method that creates a new class of pharmaceutical combinations (specific ratio combinations) that offer an improved therapeutic profile with reduced side effects is provided. Safer, more cost-effective drugs for treating various diseases or medical conditions are created by combining receptor activating, inhibiting or modulating drugs in specific ratio combinations that optimize the therapeutic profiles for various pharmaceutical compositions. The method demonstrates how to combine biological or pharmaceutical molecules or drugs in order to create specific ratio combinations that are optimized to improve the overall safety and therapeutic efficacy of the individual molecules or drugs alone. These techniques create novel receptor-activating drugs that are anticipated to prove useful for future therapeutic treatments.01-08-2009
20090012716Diabetes-related biomarkers and methods of use thereof - The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes.01-08-2009
20100088037Method for Identification and Development of Therapeutic Agents - The present invention relates generally to the field of identification and determination of bioactive amino acid sequences. In particular, the present invention provides method(s) for determining the influence of variation in host genes on selection of microorganisms with particular amino acid variants for the purpose of therapeutic drug or vaccine design or individualisation of such treatment. The invention also provides methods for identifying HLA allele-specific microorganism sequence polymorphisms that result from HLA restriction of antigen-specific cellular immune responses. It also provides diagnostic and therapeutic methodologies that may be used to measure or treat infection by a microorganism or to prevent infection by the microorganism.04-08-2010
20130166217Method and Device for Fatigue Detection - In a method for detecting driver fatigue in a vehicle having a memory device in which a fatigue model is stored, a sensor which detects at least one activity of the driver, and a sensor which detects the ambient brightness, the activity information is analyzed in the fatigue model and the brightness information is used for weighting the model.06-27-2013
20130166218Methods And Systems For Sequence Alignment Computation - A system utilizes a Single Instruction Multiple Data (SIMD) processor to efficiently determine, in parallel, the optimal global alignment for multiple input sequence pairs. The system may partition a score matrix generated for the input sequence pair into multiple sectors. While determining the cell content for each of the cells in the score matrix, the system may selectively retain computed cell contents for upper and left boundary cells of the partitioned sectors. During a traceback process, the system may retrieve the retained boundary cells for a current sector and recompute the cell contents for the current sector. Then, the system may determine the traceback path for the current sector. The system may continue to process sectors one at a time until the traceback path for the score matrix, and accordingly the optimal global alignment for the input sequence pair, is determined.06-27-2013
20130166219SYSTEMS AND METHODS FOR MEDICAL DATA PROCESSING AND ANALYSIS - We describe a system/method for predicting the outcome of a medical procedure on a patient. The system/method uses using complement cascade data representing levels of a set of complement cascade markers in the patient at a succession of peri-operative time intervals, determining deviations from a model of the response to provide a pre-symptomatic prediction of the outcome. In embodiments the complement cascade pathways include the lytic pathway and at least one of the lectin pathway, the classical pathway and the alternative pathway, and the biomarkers include at least C3. The system may include an electroluminescence or plasmon-resonance multianalyte detector to analyse a blood sample from the patient.06-27-2013
20080312841Method and apparatus for providing data processing and control in a medical communication system - Methods and apparatus for providing data processing and control for use in a medical communication system are provided.12-18-2008
20110231105Residual Compensation Including Underfill Error - A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system compensates at least 50% of the total error in the output signal with a primary function and compensates a portion of the remaining error with a residual function. The amount of error compensation provided by the primary and residual functions may be adjusted with a weighing coefficient. The compensation method including a primary function and a residual function may be used to determine analyte concentrations having improved accuracy from output signals including components attributable to error.09-22-2011
20120078528PATIENT DIAGNOSIS USING DRUG RELATED HOLISTIC DATA - Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. A computer-implemented method for integrated comparative holistic analysis of drug development and related quantifiable patient treatment decision support for a medical condition having a known disease signature.03-29-2012
20080294351METHOD FOR PREDICTING SECONDARY STRUCTURE OF NUCLEIC ACID SEQUENCE, A PREDICTOR FOR SECONDARY STRUCTURE OF NUCLEIC ACID SEQUENCE AND A PREDICTING PROGRAM FOR PREDICTING SECONDARY STRUCTURE OF NUCLEIC ACID SEQUENCE - An exemplary object of the present invention is to provide method, predictor and predicting program for predicting secondary structure of nucleic acid sequence capable of evaluating not only overall similarity and but also localized similarity of secondary structure of nucleic acid sequence. A method according to an exemplary aspect of the present invention includes the steps of:11-27-2008
20080294350PERFORMING DATA ANALYSIS ON CLINICAL DATA - Reference intervals are established and/or validated based on existing clinical data and exclusion criteria, such as diagnosis coding. A Reference Interval Test Engine is designed to statistically analyze large volumes of existing clinical lab test results to establish and evaluate reference intervals for specific population subgroups and/or to provide other applications.11-27-2008
20080294348BIOLOGICAL INFORMATION MEASUREMENT DEVICE AND METHOD OF MEASURING BIOLOGICAL INFORMATION SUITABLE FOR REGULAR MEASUREMENT OF BIOLOGICAL INFORMATION - A biological information measurement device stores, in a storage unit, biological data representing data of calculated biological information and measurement date data in association with each other. The biological information measurement device displays, as measurement frequency specifying information, information for specifying frequency of day(s) when the measurement was conducted, in a prescribed period from a current date based on a plurality of pieces of measurement date data stored in the storage unit and an output from a time keeping unit.11-27-2008
20110029248APPARATUS FOR MEASURING AND PREDICTING PATIENTS' RESPIRATORY STABILITY - An apparatus (02-03-2011
20110029247Exponential Sampling Of Red And Infrared Signals - Methods and systems are provided that include sampling a light intensity signal at different frequencies based on the waveform of the signal to produce a more accurate digitized signal. The light intensity signal is an analog signal proportional to the intensity of light received at a detector of a pulse oximetry system. In one embodiment, the signal may be sampled exponentially during pulse width periods, such that the end of the pulse width periods where the signal reaches a maximum amplitude may be sampled more frequently. The signal may also be exponentially sampled or oversampled during periods when the signal is expected to near maximum amplitude. Further, the signal may be sampled less frequently during low amplitude periods of the signal, and during dark periods, such that processing power may be conserved.02-03-2011
20120271555DEVICE FOR MEASURING TISSUE STIFFNESS - This invention relates to measuring stiffness of a biological sample Specifically, the invention relates to a milliprobe indentation device that comprises a force probe and a micromanipulator and uses thereof for measuring stiffness of biological samples10-25-2012
20120035857COMPUTER-IMPLEMENTED BIOLOGICAL SEQUENCE IDENTIFIER SYSTEM AND METHOD - A computer-implemented biological sequence identifier (CIBSI) system and method for selecting a subsequence from biological sequence data according to at least one selection parameter. The at least one selection parameter corresponds to a likelihood of returning a meaningful result from a similarity search.02-09-2012
20110246077Methods and Apparatus for Screening for Chromosomal Abnormalities - This invention generally relates to methods, apparatus, and computer program code for antenatal screening for chromosomal abnormalities, in particular Down's Syndrome. A method of determining a likelihood of a fetus carried by a pregnant mother having a chromosomal abnormality, a first biological, parameter being suitable for screening said fetus for said chromosomal abnormality, the method comprising: receiving first data from a first stage of pregnancy of said mother, said first data comprising data representing a first value of said first biological parameter; receiving second data from a second, later stage of said pregnancy, said second data comprising data representing a second value of said first biological parameter; and determining likelihood data from said first and second data, said likelihood data representing the likelihood of said fetus having a chromosomal abnormality.10-06-2011
20100030485SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR - Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.02-04-2010
20120084011METHODS FOR MANAGING CANCER PATIENT CARE - Methods for managing the care of a cancer patient are provided. Generally, the methods comprise calculating a risk score from characteristics obtained from a cancer patient with a plurality of nomograms comprising the characteristics and a plurality of competing risk factors, using a program to calculate risk scores; determining the patient's prognosis based on the risk score; and treating the patient with a regimen capable of improving the prognosis of a cancer patient having substantially the same risk score. Systems and computer readable media for practicing the methods are also provided.04-05-2012
20090306904Hydrophobic Moment of Multi-Domain Proteins - Techniques for protein structure analysis are provided. In one aspect, an apparatus for characterizing a multi-domain protein structure comprises the following steps. For at least one domain, a hydrophobic dipole, e.g., defined as a first-order hydrophobic moment of the domain, is calculated. A score representing the orientation of the hydrophobic dipole of the at least one domain relative to a hydrophobic dipole of one or more other domains of the multi-domain protein structure is then calculated.12-10-2009
20110046888METHOD OF DIAGNOSING TUMOR DISORDERS IN HUMANS - The invention is used for the diagnosis of human tumoral diseases. The diagnosis method consists of preparing films from patient arterial and venous blood, processing said films using a conventional method such as fixing or dyeing, measuring the surface areas of the arterial and venous blood lymphocyte nuclei and comparing said surface areas to corresponding cell surface areas of different lymphocyte groups, plotting regression lines for the arterial and venous blood according to the values thus obtained, determining the percentage thereof for each lymphocyte group, plotting the influence curve thereof in the form of a function of the diameter of corresponding lymphocyte groups, introducing weight factors whose quantity increases along the lymphocyte diameter decrease, multiplying said factors by the lymphocyte percentage, and plotting the sums' correspondence for the arterial and venous blood in the form of the function of the difference therebetween. The diagnosis, location of the tumor, and degree of advancement of the oncological process are jointly determined according to the intersection and correlation of the regression lines and according to characteristic pictures and areas of the curves obtained.02-24-2011
20120271553ANALYZING THE EXPRESSION OF BIOMARKERS IN CELLS WITH CLUSTERS - A data set of cell profile data is stored. The cell profile data includes multiplexed biometric image data describing the expression of a plurality of biomarkers. Cell profile data is generated from tissue samples drawn from a cohort of patients having an assessment related to the commonality. Multiple sets of clusters of similar cells are generated from the data set; the proportion of cells in each cluster is examined for an association with a diagnosis, a prognosis, or a response; and a predictive set of clusters is selected based on model performance. One predictive set of clusters is selected based on a comparison of the performance of at least one model of the plurality of sets of clusters. Display techniques that aid in understanding the characteristics of a cluster are disclosed.10-25-2012
20090312952Early Diagnosis of Acute Coronary Syndrome - The invention relates to methods for the early diagnosis of Acute Coronary Syndrome.12-17-2009
20090112481HIGH-RESOLUTION MELTING ANALYSIS - The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. In one aspect, methods and systems are disclosed for resolving a denaturation curve of a sample containing a first and second nucleic acid into a resolved denaturation curve for the first nucleic acid and a resolved denuration curve for the second nucleic acid.04-30-2009
20100235104Methods for Classification of Toxic Agents and Counteragents - Methods and systems for evaluating biological dataset profiles relating to toxic agents including candidate pharmaceuticals, environmental agents, biowarfare and chemical warfare agents are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate agents.09-16-2010
20080228406SYSTEM AND METHOD FOR FUNGAL IDENTIFICATION - A service for the identification of at least one fungal organism suspected of being present in a test sample is described and comprises a processing capacity for the sample, a sequencing capacity for generating sequence information, a sequence information processing capacity, an assessment capacity, and a reporting capacity for reporting results to an end user. Also described are methods and systems of determining the presence and identity of at least one fungus in a sample.09-18-2008
20110282588Method to automatically identify peaks and monoisotopic peaks in mass spectral data for biomolecular applications - A method for automatically identifying peaks in mass spectral data includes estimating m/z-dependent levels of background and noise, detecting all peaks with signal-to-noise ratio above a user-specified threshold, and compiling a list of all detected peaks including their m/z positions and intensities. The method can be extended to automatically detect monoisotopic peaks, to detect monoisotopic peaks in the presence of chemical noise, and to detect resolved isotopic clusters at high mass.11-17-2011
20090018778Method Related to Gestation Periods - The present invention relates generally to a method for estimating the time elapsed within a gestation period of a pregnant or potentially pregnant ruminant, such as a cow. The method involves estimating the time elapsed within a gestation period of a pregnant or potentially pregnant ruminant, including the steps of providing a sample from the ruminant; calculating a value of a pregnancy indicator in the sample; and applying a regression formula to the value of the pregnancy indicator to provide an estimate of the time elapsed within the gestation period. The method may further include the steps of categorising the pregnancy status of the ruminant, qualitatively assessing the level of the pregnancy indicator value for application thereto of the regression formula, using the time elapsed to derive an estimate of a gestation-related event, and validating the estimated date of a gestation related event. The invention further provides computer software to generate an estimate of the time elapsed within a gestation period of a pregnant ruminant, and systems for generating an estimate of the time elapsed.01-15-2009
20110010101SIMPLIFIED PERITONEAL EQUILIBRATION TEST FOR PERITONEAL DIALYSIS - A simplified peritoneal equilibration test (S-PET) is disclosed. Instead of a lengthy peritoneal equilibration test (PET), the simplified procedure requires no blood sample and may use data from as few as two or three samples to classify a peritoneal membrane of a user. Typically, a peritoneal membrane or peritoneum of a dialysis patient, or other person, is classed as a high transport membrane, high-average transport membrane, a low-average transport membrane or a low transporter membrane. The S-PET may be performed at home by a user without the need to submit a blood sample. Kits for analyzing the samples may be furnished for home use. The kits may use disposable strips, microfluidic analyzers or chemical reagents, or may alternatively include reusable analysis equipment, such as optical or conductivity analysis equipment.01-13-2011
20110040486Method for standardization of chemical and therapeutic values of foods and medicines using animated chromatographic fingerprinting - The present invention provides a method of standardization of chemical and therapeutic properties and quality of foods and medicines. The present invention provides a method of chromatographic finger printing facilitating correlation of traditional methods used for chemical and therapeutic standardization of medicines and humors in the living things with physico chemical properties of the medicines and their constituents. The method is used for the qualitative and quantitative analysis of the energy involved in the medicines and living things and to understand various bio chemical reactions in living things using an energy system. It provides a rational basis to understand the traditional methods of assessment of chemical and therapeutic qualities of materials used for the said purpose. The present invention also provides the influence, of factors like pH, temperature, viscosity and ionic nature of the media along with atomic and molecular properties indicating the chemical and therapeutic values of the foods and medicines of natural and synthetic nature. The analysis of biological samples like blood indicated the utility of the method for the assessment of clinical pathological conditions of healthy and diseased. This facilitates for a better drug discovery, drug monitoring, drug targeting and drug profiling using different features of 3-D animated energy box created after analyzing the sample by different analysis, separation and detection methods.02-17-2011
20110040492SYSTEM AND METHOD FOR MEASURING PHASE RESPONSE CHARACTERISTIC OF HUMAN-BODY IN HUMAN-BODY COMMUNICATION - There is provided a system and a method for measuring phase response characteristic of a human body in human-body communication. The system and method may be useful to measure phase response characteristic of the human body without forming a common ground line between a reference signal transmitter and a reference signal receiver by transmitting a first reference signal through the human body and transmitting a second reference signal through the optical cable.02-17-2011
20110040488SYSTEM AND METHOD FOR ANALYSIS OF A DNA SEQUENCE BY CONVERTING THE DNA SEQUENCE TO A NUMBER STRING AND APPLICATIONS THEREOF IN THE FIELD OF ACCELERATED DRUG DESIGN - The present invention relates to a system and a method for analysis of a DNA sequence by converting the DNA sequence into a unique number string using a genomic number system in order to extract and/or analyze biological information. The invention is particularly useful in the development of new drugs or active chemical agents.02-17-2011
20100125419Food content detector - A system may include utensil means for portioning a foodstuff into a first portion and a second portion, a means for detecting a first portion size for the first portion with the utensil means, a means for detecting a second portion size for the second portion with the utensil means, and a means for determining a cumulative amount of portioned foodstuff based upon the first portion size and the second portion size.05-20-2010
20110093209METHODS AND SYSTEMS FOR SIMULTANEOUS ALLELIC CONTRAST AND COPY NUMBER ASSOCIATION IN GENOME-WIDE ASSOCIATION STUDIES - Methods and systems are provided for performing allelic copy number association in genome-wide association studies. Also provided are computer-readable media for storing instructions for performing the genomic marker association studies. The methods include performing genomic marker association studies wherein allelic contrast and copy number are analyzed simultaneously, comprising the steps of receiving measurements of intensity for each of two alleles (A and B) in a biological sample set; computing a sum value (S) and a difference value (D) of the intensities; and employing a statistical model to determine a potential association of the S and/or the D value with an outcome, wherein a statistically significant coefficient of the S intensity indicates an association of the copy number with the outcome and a statistically significant coefficient of the D intensity indicates an association of the allelic contrast with the outcome.04-21-2011
20110301859PERSONALIZED MOLECULAR MEDICINE - A computer based system and methods for generating and outputting information relating to personalized therapy, including diagnosis and/or treatment is described herein.12-08-2011
20110301853Tumor Discriminator - A tumor discriminator determines if a biological sample is diseaseous. Summarized expression value samples in a reference dataset are determined. The summarized expression value being a summation of gene expression levels for disease and normal samples. A biological sample summarized expression value is determined using a gene expression profile for a biological sample. A disease sample distance is estimated from the biological sample summarized expression value to a location in the disease sample space. The disease sample space defined by a statistical analysis of the disease samples. A normal sample distance is estimate from the biological sample summarized expression value to a location in the normal sample space The normal sample space defined by a statistical analysis of the normal samples. The disease sample distance is compared with the normal sample distance to determine if the biological sample is diseaseous.12-08-2011
20110301861CAPACITANCE DETECTION IN ELECTROCHEMICAL ASSAY WITH IMPROVED SAMPLING TIME OFFSET - A method and system are provided to determine fill sufficiency of an electrochemical biosensor test cell by determining capacitance of the electrochemical test cell.12-08-2011
20110301860USING DIFFERENTIAL SCANNING CALORIMETRY (DSC) FOR DETECTION OF INFLAMMATORY DISEASE - Disclosed herein in various embodiments are systems and methods for categorizing biological fluids obtained from subjects into one or more disease or treatment categories. Embodiments of the systems and methods may transform easily obtainable body fluids such as blood, plasma, spinal fluid, and other fluids into signature differential scanning calorimetry (DSC) thermograms that may be used to distinguish a positive or negative correlation with a specific inflammatory disease, such as an autoimmune disease. Also disclosed are methods of detecting, diagnosing, and/or monitoring an inflammatory disease in a subject.12-08-2011
20110301858SYSTEMS AND METHODS FOR COMPUTER ASSISTED ALIGNMENT OF CONFORMERS - A computer-assisted method for determining the optimal conformers of biologically active molecules binding any particular receptor. Starting from a set of molecules of known activity at the receptor a conformer library may be generated using any method known to the art including commercially available software. Pair-wise comparison of conformers create alignments and similarity scoring of the alignments. The set of pair-wise alignments is used by the present invention to determine optimal bioactive conformations and to align these conformations in 3-D space for determining the binding mode of the active compounds The invention includes a computer program implementation of such a method.12-08-2011
20110301857Slope-Based Compensation Including Secondary Output Signals - A biosensor system determines analyte concentration from analytic and/or secondary output signals. The biosensor system adjusts a correlation for determining analyte concentrations from output signals with one or more index functions extracted from the output signals. The index functions determine at least one slope deviation or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias.12-08-2011
20110301856METHODS AND SYSTEMS FOR DRUG SCREENING AND COMPUTATIONAL MODELING BASED ON BIOLOGICALLY REALISTIC NEURONS - A method for screening a test composition for potential efficacy in treatment of a disorder includes a first computer model representative of a volume of disease-afflicted neural tissue comprising biologically realistic neurons exposed to the test composition; and providing an initial excitation to the first computer model. Following a selected computation interval, a first outcome is determined. The first outcome indicates a response of the first computer model to the initial excitation and indicates whether the test composition has the potential to be effective in treating the disorder.12-08-2011
20110301854Method of Determining Allele-Specific Copy Number of a SNP - A method of estimating the allele-specific copy number of a SNP in a test genome is provided. In certain embodiments, the method involves: a) calculating a plurality of probability distribution functions that fit a plurality of log ratios indicating which alleles of a plurality of single nucleotide polymorphisms (SNPs) are present in diploid regions of a test and reference genome; and b) estimating the allele-specific copy number of a SNP of the test genome using said plurality of probability distribution functions.12-08-2011
20110301852Systems And Methods For Estimating Stability Of A Continuous Wavelet Transform - Methods and systems are disclosed for analyzing a physiological signal obtained from a patient. The physiological signal is transformed using a continuous wavelet transform to generate a transformed signal, and a scalogram is generated from the transformed signal. A region of relative high energy in the scalogram is identified, and dimension information regarding the region is determined. The dimension information is processed to determine physiological information about the patient and confidence information regarding the signal. A storage device coupled to the electronic processing equipment may be used to store the physiological and confidence information.12-08-2011
20110288784Monitoring Energy Expended by an Individual - Methods, apparatuses and systems of monitoring energy expended by an individual are disclosed. One method includes sensing, by a motion sensor, motion of the individual, identifying a plurality of activities performed by the individual over a period of time based on the identified motions, estimating, by a processor, energy expended by the individual for each of the plurality of the plurality of identified activities, and estimating energy expended by the individual by summing the estimated energy expended for each of the plurality of activities.11-24-2011
20110288781SYSTEMS AND METHODS FOR CHARACTERIZING A BIOLOGICAL CONDITION OR AGENT USING SELECTED GENE EXPRESSION PROFILES - Methods are provided for evaluating a biological condition of a subject using a calibrated profile data set derived from a data set having a plurality of members, each member being a quantitative measure of the amount of a subject's RNA or protein as distinct constituents in a panel of constituents. The biological condition may be a naturally occurring physiological state or may be responsive to treatment of the subject with one or more agents. Calibrated profile data sets may be used as a descriptive record for an agent.11-24-2011
20110288783SYSTEM FOR PREDICTING DRUG EFFECTS AND ADVERSE EFFECTS AND PROGRAM FOR THE SAME - A drug effect-adverse effect prediction system includes a clinical data analysis table generating part, for each combination of genotypes relating to a drug effect or adverse effect, for generation of an analysis table for handling cases related to presence or absence of the drug effect or adverse effect. The system also includes a reliability analysis part, a discrimination formula generating part, a prediction part, and a discrimination formula optimizing part.11-24-2011
20110288782SYSTEM FOR DETERMINING STATE AND ACTION OF HUMAN BODY AND METHOD OF DETERMINING STATE OF HUMAN BODY, USING AN OPTICAL SIGNAL - Disclosed herein is a system for determining the state and action of the human body using an optical signal. The system includes an optical signal transmission module configured to generate and output the optical signal, an optical signal transfer module configured to include at least one optical signal transfer path that is wearable on a region of the human body and that has at least one cut portion, and a human body state analysis module configured to determine a variation in the state of the human body by calculating the light transmission ratio of the at least one optical signal transfer path which varies depending on the gap of the at least one cut portion of the at least one optical signal transfer path. The gap varies depending on a variation in a circumference of the region of the human body.11-24-2011
20110288779SYSTEM AND METHOD OF DATA-DEPENDENT ACQUISITION BY MASS SPECTROMETRY - Systems, computer-readable media, and methods using mass spectrometry to analyze a sample are provided. For example, a method includes: acquiring a precursor ion spectrum; analyzing the precursor ion spectrum to identify precursor ions that preliminarily match one or more peptides that each belong to at least one protein of interest for the analysis; selecting each of the identified precursor ions in an order according to a ranking protocol for maximizing the number of proteins that are identified in the sample; for each selected precursor ion: acquiring a corresponding product ion spectrum, determining whether the acquired product ion spectrum matches one of the peptides that belong to the set of proteins of interest, and identifying a matched peptide as being present in the sample; and identifying proteins of interest that are present in the sample based on the peptides that are identified as being present in the sample.11-24-2011
20110288780Methods for Non-Invasive Prenatal Ploidy Calling - Methods for non-invasive prenatal ploidy calling are disclosed herein. Methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of DNA from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father are disclosed herein. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.11-24-2011
20120016594METHOD FOR TRANSLATING GENETIC INFORMATION FOR USE IN PHARMACOGENOMIC MOLECULAR DIAGNOSTICS AND PERSONALIZED MEDICINE RESEARCH - A gene-drug specific system for classifying individual genetic variants based on strength-of-evidence of clinical utility from published scientific and clinical data that support their effect on modifying drug response and behavior. This allows categorization of the genetic variants into evidence classes that have a wide range of uses such as pharmacogenomic molecular diagnostics and personalized medicine research designed to guide the clinical implementation of PGx. Furthermore, this information can be combined with a knowledgebase of drug-response phenotypes, a knowlegebase of specific drug-induced outcomes and individual patient diplotype information for a gene-drug combination into a programmed computer to output corresponding patient-specific predicted drug responses.01-19-2012
20120016593METHOD AND APPARATUS FOR WORLDWIDE SREENING FOR HUMAN PAPILLOMA VIRUS - The invention relates to in vitro methods of screening female human subjects for the presence of human papillo mavirus, for example as a marker of cervical epithelial precancer. In particular, the invention provides methods and apparatus which can be used to filter a patient data set of measurements related to multiple HPV types according to the geographical location of the patient under test, so that only those measurements of HPV types which are pre-determined to be relevant for the geographical region in which the patient under test is located are selected for output/display.01-19-2012
20100305867ANALYSIS OF AQUIOUS SAMPLE BY LIGHT TRANSMITTENCE - A method for analysis of an aqueous sample includes determining a first reading of a sample, and comparing the first reading to a first read index to determine a first read probability wherein the first read probability gives either a positive or a negative result for the sample. The method includes determining a second reading for the sample, and comparing the second reading to a second read index, wherein a second read probability is determined according to the reading and the second read index. The second read probability gives either a positive or a negative result for the sample. From the first and second readings, a species and a life phase of the species are determined.12-02-2010
20110295514Computational Methods For Translating A Sequence Of Multi-Base Color Calls To A Sequence Of Bases - Disclosed are systems and methods for resequencing using color calls. A DNA sample is encoded and sequenced according to a multi-base code producing a string of read color calls for a fragment of the sample. A reference sequence is obtained. The string of read color calls is mapped to the reference sequence. A base sequence is extracted from the reference sequence. The base sequence is encoded as a string of reference color codes according to the multi-base code. The string of read color calls is aligned with the string of reference color codes and mismatches in the alignment are detected. One or more mismatches of the string of read color calls are annotated as inconsistent. The one or more inconsistent mismatches of the string of read color calls are corrected. The string of corrected read color calls is decoded to bases producing a read sequence.12-01-2011
20110295515METHODS AND SYSTEMS FOR FAST AUTOMATIC BRAIN MATCHING VIA SPECTRAL CORRESPONDENCE - Methods and systems determine a correspondence of two sets of data, each data set represents an object. A weighted graph is created from each data set, and a Laplacian is determined for each weighted graph, from which spectral components are determined. The spectral components determine a coordinate of a node in a weighted graph. Nodes of a weighted graph are weighted with a quantified feature related to anode. A coordinate related to a quantified feature of a node is added to the coordinate based on the spectral components. Spectral components related to a weighted graph are reordered to a common ordering. Reordered spectral components related to the first and second data set are aligned and a correspondence is determined. An object may be a brain and a feature may be a sulcal depth. Other objects for which a correspondence may be determined include an electrical network, an image and a social network.12-01-2011
20110295512GRADIENT INJECTION FOR BIOSENSING - A single injection gradient with a biosensor, both structural and methodological, achieves the binding of analyte to immobilized ligand over a wide concentration range without the necessity of regeneration of the sensing area. A gradient of concentrations adjacent to or within a flow cell facilitates kinetic analysis of interactions without requiring multiple discrete volumes or injections to achieve a range of concentrations. A continuous gradient fluid is preferably formed directly adjacent to the flow cell inlet or a region of sample/buffer dispersion at an injection point into a flow channel of a flow cell. The analyte gradient may be flowed through the flow cell from a low analyte concentration. Multiple component gradients are also provided.12-01-2011
20110295513INFORMATION PROCESSING APPARATUS, INFORMATION OUTPUT METHOD, AND PROGRAM - There is provided an information processing apparatus including a data acquisition section which acquires input data for recognizing a growth status of a living thing, a recognition section which recognizes a growth status of the living thing based on the input data acquired by the data acquisition section, an agent control section which determines a state of an agent associated with the living thing depending on the growth status of the living thing recognized by the recognition section, and an output section which outputs an agent image corresponding to the state of the agent determined by the agent control section.12-01-2011
20110295511APPARATUS AND METHOD FOR DETECTING THE PRESENCE OF AN AGENT - An apparatus and method for detecting an agent utilizes a substrate, a waveguide on the substrate, a light source, a photo-detector, an optical coupler on the substrate, and a processor. The light source is configured to emit light into the waveguide. The photo-detector is configured to detect light. The optical coupler is configured to direct a first portion of light propagating from the waveguide towards the photo-detector and to direct a second portion of the light propagating from the waveguide back into the waveguide. The waveguide and the optical coupler at least partially form a resonator. A substance is at least one of embedded within the waveguide and adjacent to the waveguide. The substance is reactive to the agent. The processor detects a change in a resonance lineshape of the resonator caused by the reaction of the substance to the agent.12-01-2011
20100169025METHODS AND GENE EXPRESSION SIGNATURE FOR WNT/B-CATENIN SIGNALING PATHWAY - Methods, biomarkers, and expression signatures are disclosed for assessing the regulation status of Wnt/β-catenin signaling pathway in a cell sample or subject. More specifically, several aspects of the invention provide a set of genes which can be used as biomarkers and gene signatures for evaluating Wnt/β-catenin pathway deregulation status in a sample; classifying a cell sample as having a deregulated or regulated Wnt/β-catenin signaling pathway; determining whether an agent modulates the Wnt/β-catenin signaling pathway in sample; predicting response of a subject to an agent that modulates the Wnt/β-catenin signaling pathway; assigning treatment to a subject; and evaluating the pharmacodynamic effects of therapies designed to regulate Wnt/β-catenin pathway signaling.07-01-2010
20090299642METHOD - A method of analyzing a keratin sample from a subject to improve sensitivity and specificity of a diagnostic test for a pathological state in the subject by exposing the keratin sample to incident energy derived from an energy source; receiving radiated energy from the keratin sample consequent upon impingement of the incident energy on the keratin sample; passing at least a portion of the radiated energy received from the keratin sample through a transducer so as to derive subject specific data; processing subject specific derived data; comparing the processed subject specific data thus derived with a second group of reference data present in a reference database; wherein the second group of reference data is consistent with a presence of the pathological state in the subject; and including the steps of applying an appropriate algorithm to said subject specific data prior to said step of comparing thereby to improve sensitivity and specificity relative to said reference data.12-03-2009
20090292480Synthetic Microfluidic Microvasculature Network - A synthetic microfluidic microvasculature network and associated methods mimic the structure, fluid flow characteristics, and physiological behavior of physiological microvasculature networks. Computational methods for simulating flow and particle adherence in synthetic and physiological microvascular systems and methods for determining parameters influencing particle adhesion and drug delivery are described with applications in the optimization of drug delivery and microvascular treatments and in describing disease mechanisms that affect the microvasculature.11-26-2009
20090299640Methods and Compositions Involving Intrinsic Genes - Disclosed are compositions and methods related intrinsic gene sets and methods and compositions related to detecting and classifying cancer.12-03-2009
20120065892SCORING SYSTEM FOR THE PREDICTION OF CANCER RECURRENCE - The present invention relates to a scoring system for the prediction of cancer recurrence by selecting genes and/or proteins whose expression patterns associated with recurrence of cancer, and generating formulae with the selected genes and/or proteins for the prediction of cancer recurrence. The present invention relates to a kit for determining the likelihood of recurrence of cancer, comprising DNA chip, oligonucleotide chip, protein chip, peptides, antibodies, probes and primers that are necessary for effecting DNA microarrays, oligonucleotide microarrays, protein arrays, northern blotting, in situ hybridization, RNase protection assays, western blotting, ELISA assays, reverse transcription polymerase-chain reaction to examine the expression of at least 2, 4, 6, 10, 12 or more genes and/or proteins, that are indicative of cancer recurrence.03-15-2012
20080243393Biometric information measuring apparatus and biometric information measuring system - A biometric information measuring apparatus has a storage device for storing data concerning a biometric signal or biometric information derived from the biometric signal in association with position information indicating the current location of a sensor unit of the apparatus. Since the biometric information measuring apparatus provides the position information acquired when the data on the biometric signal or the biometric information was obtained, one can know the location and behavior of a subject at the time of measurement and exactly analyze the biometric information on the subject.10-02-2008
20130218476METHODS FOR THE ANALYSIS OF HIGH RESOLUTION MELT CURVE DATA - The present application provides for various embodiments of methods for the analysis of high resolution melt (HRM) curve data; where statistical assay variations in melt curve data may result from system noise in an analysis system. Such system noise may arise from various sources, such as the thermal non-uniformity of a thermocycler block in a thermal cycler apparatus, a detection system, etc. Additionally, various methods for the analysis of HRM curve data may provide an identification of a sample without the need for a user inputted information.08-22-2013
20080228409SYSTEMS AND METHODS FOR PROBE DESIGN BASED ON EXPERIMENTAL PARAMETERS - Systems and methods for using the same to select or design probes specific for a target nucleic acid based on experimental parameters are provided. Also provided are computer program products for executing the subject methods.09-18-2008
20100070192OPTIMIZATION OF CROSSOVER POINTS FOR DIRECTED EVOLUTION - Methods and devices for more efficiently engineering diversity into recombinant polypeptides and/or nucleic acids are provided herein. For example, a variety of methods of selecting and/or assessing potential crossover sites in an amino acid sequence or a nucleotide sequence are provided, as well as the resulting chimeric product sequences. These methods include, e.g., consideration of structural, functional and/or statistical data in the selection and assessment of sequences and crossover sites for use in recombination.03-18-2010
20090125241REAL TIME WATER ANALYSIS SYSTEM FOR METALS, CHEMICALS, RADIOLOGICAL AND BIOLOGICAL MATERIALS (CBRNME) WITHIN WATER - A method and water analysis system are provided to automatically, and without manual intervention, detect and identify contamination and/or hazardous material within one or more water samples from a potable and/or effluent water system. The method includes collecting a water sample from a potable and/or effluent water system; monitoring, in response to the collecting, sensors-detectors that are located in proximity to the collected water sample and receiving sensor-detector data from the sensors-detectors. The sensors-detectors include: laser induced breakdown spectrometry (LIBS) sensor technology, gas chromatography sensor technology, mass spectroscopy sensor technology, calorimetric spectroscopy sensor technology, and radiation detection technology. The method further includes spectrally analyzing, in response to the monitoring, the received sensor-detector data to detect, identify, and quantify, metals, chemicals, radiological materials, and biological materials, within the collected water sample.05-14-2009
20100070195COMPUTER-IMPLEMENTED BIOLOGICAL SEQUENCE IDENTIFIER SYSTEM AND METHOD - A method of: submitting reference sequences to a taxonomic database to produce taxonomic results; and reporting a taxonomic identification based on the taxonomic results. The reference sequences are the output of genetic database queries that return a score for each reference sequence. A method for processing a biological sequence obtained from an assay by: converting base calls located in a predetermined list of positions within the biological sequence to N; and determining the ratio of single nucleotide polymorphisms in the biological sequence relative to a reference sequence. Each entry in the predetermined list of positions represents the capability of a substance hybridizing to a microarray used to generate the biological sequence. The substance is not the nucleic acid of a target pathogen.03-18-2010
20100070189METHOD FOR ASSESSING DEGREE OF RELIABILITY OF NUCLEIC ACID BASE SEQUENCE - Disclosed herein is a method for assessing the degree of reliability of a nucleic acid base sequence, by which a higher-accuracy assessment result of the degree of reliability can be obtained as compared to a case where the degree of reliability is assessed based on only the evaluation of analytical data. The method includes the steps: (A) when measured data is processed into analytical data, computing a processing evaluation value E103-18-2010
20100036615Method for Measuring Information of Technical and Biological Systems - The invention relates to a method for measuring potential information of a biological or technical system. The aim of the invention is to receive signals using less energy. To achieve this, random generators are used as receivers of low-energy quanta, since the random generators can be regarded and implemented as antennae and receivers of signals of this type. The extensive natural transmission range of low-energy quanta can also be used to receive potential information from systems.02-11-2010
20110264375COMPUTER-ASSISTED MEANS FOR ASSESSING LIFESTYLE RISK FACTORS - The present invention relates to methods of assessing disease susceptibility associated with dietary and lifestyle risk factors. The invention provides for analysis of alleles at loci of genes associated with lifestyle risk factors, and the disease susceptibility profile of an individual is determined by reference to datasets which further match the risk factor with lifestyle recommendations in order to produce a personalized lifestyle advice plan.10-27-2011
20110218738CHARACTERIZATION OF MOLECULES - The invention involves obtaining signatures of species (including chemical, biological, or biochemical molecules) and/or signatures of interactions between species and using them to characterize species, characterize interactions, and/or identify species that could be useful in a variety of settings. Signatures can be obtained using aqueous multi-phase partitioning and can be used to predict molecular interactions for applications such as drug discovery. A plurality of aqueous multi-phase partitioning arrangements can define an overall system providing an information-intensive signature, maximizing precision and sensitivity.09-08-2011
20100191475METHOD FOR IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF AGENTS WHICH MODULATE ION CHANNEL ACTIVITY - Materials, methods and a computer system are provided which facilitate the identification and characterization of modulators of potassium ion channels, particularly the HERG channel.07-29-2010
20090204335Method for acquiring and managing morphological data of persons on a computer network and device for carrying out said method - The invention relates to a method for acquiring and managing morphological data of persons on a computer network, wherein said data is used for producing and/or delivering ready-made individually dimensioned clothes by at least one of the plurality of manufacturers. The inventive method consists, at a preliminary stage, in forming a first data base (08-13-2009
20090177407METHOD AND DEVICE FOR ANALYSIS, VERIFICATION AND QUALITY ASSURANCE OF DRUGS FOR INJECTION OR INFUSION - The present invention relates to a method and device for non-invasive analysis of the identity and concentration of drugs that are to be administered by injection or infusion.07-09-2009
20100114500ANALYSIS OF DNA - The invention provides methods for providing information on the probability of DNA samples being contaminated over days, weeks and months in relation to collection, processing and analysis of DNA samples. Methods are also provided for analysing the likelihood of a result arising due to contamination and/or determining the analysis protocol to be applied to a DNA sample and/or methods of operating databases, particularly containing DNA profiles.05-06-2010
20090150082Method and system for realizing collaboration between bio-signal measurement devices - The present invention relates to technology for realizing collaboration between bio-signal measurement devices used for personal health care. In a method of realizing collaboration between bio-signal measurement devices, connection to a plurality of bio-signal measurement devices for measuring bio-signals from a user is made, and a plurality of pieces of bio-signal data is received from the bio-signal measurement devices. First features are calculated from respective pieces of bio-signal data. Data required for calculation of second features is selectively received from the calculated first features, second features are calculated. The calculated first and second features are normalized, and the normalized first and second features are transmitted to at least one application program.06-11-2009
20090150080METHODS OF GENETIC ANALYSIS INVOLVING THE AMPLIFICATION OF COMPLEMENTARY DUPLICONS - The invention relates to methods for genetic analysis of DNA sequences containing complementary duplicons which are duplicated and linked DNA sequences separated by an intermediate sequence. Furthermore, the invention relates to the Bidirectional Amplification of Complementary Duplicons (BACD) using a single primer. The amplification of complementary duplicons can be used for a variety of purposes such as, but not limited to, determining the species from which a sample comprising genomic DNA is derived, or used as a marker for a trait of interest. Also provided are means for analysing large datasets which can be used to identify primers useful for the genetic analysis methods of the invention.06-11-2009
20100070190MULTI-STAGE, REGRESSION-BASED PCR ANALYSIS SYSTEM - Systems and methods are provided for analyzing data to determine properties of a PCR process or other process exhibiting amplification or growth. Data representing an amplification can be distinguished from data representing a jump or other error. A modified sigmoid function containing a drift term may be used in determining the properties. A multi-stage functional fit of the amplification data can provide increased accuracy and consistency of one or more of the properties. A baseline of the amplification data can be determined by analyzing an integrated area of a first derivative function of the data. A reference quantitation value can also be determined from locations of maxima of different derivative functions of the amplification data, e.g., a weighted average of the maxima locations for the second and third derivatives may be used.03-18-2010
20090157327Electronic Device, Arrangement, and Method of Estimating Fluid Loss - There is provided an electronic device comprising: a processing unit configured to receive skin temperature data generated by a measuring unit, to receive performance data from a measuring unit, and to determine a theoretical fluid loss value on the basis of the received performance data. The electronic device further comprises: a processing unit configured to determine a relation between a predetermined perspiration threshold and a skin temperature value deduced from the received skin temperature data; and to determine a real fluid loss value on the basis of the theoretical fluid loss value and the determined relation between the predetermined perspiration threshold and the skin temperature value.06-18-2009
20100268477Systems and Methods for Calibrating Physiological Characteristic Sensors - A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals, obtaining reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals, calculating the calibration characteristics using the reference glucose values and corresponding glucose monitor data to regress the obtained glucose monitor data, and calibrating the obtained glucose monitor data using the calibration characteristics. In additional embodiments, calculation of the calibration characteristics includes linear regression and, in particular embodiments, least squares linear regression. Alternatively, calculation of the calibration characteristics includes non-linear regression. Data integrity may be verified and the data may be filtered. Further, calibration techniques may be modified during a fast rate of change in the patient's blood glucose level to increase sensor accuracy.10-21-2010
20100268476PROCESS FOR IDENTIFYING SIMILAR 3D SUBSTRUCTURES ONTO 3D ATOMIC STRUCTURES AND ITS APPLICATIONS - Our disclosure pertains to the field of structural biology and relates to a process to compare various three-dimensional (3D) structures and to identify functional similarities among them. Our process of comparison of 3D atomic structures is based on the comparisons of defined chemical groups onto the 3D atomic structures and allows the detection of local similarities even when neither the fold nor sequence for example aminoacid sequences for polypeptides sequences or nucleotide sequences for nucleic acid sequences are conserved. This process requires the attribution of selected physico-chemical parameters to each atom of a 3D atomic structure, then the representation of each 3D atomic structure by a graph of chemical groups.10-21-2010
20100268475ENVIRONMENT TEMPERATURE MEASURING METHOD, LIQUID SAMPLE MEASURING METHOD, AND MEASURING DEVICE10-21-2010
20090099781METHOD AND SYSTEM FOR ESTIMATING A BLOOD SUGER CONDITION - A blood sugar condition is estimated by (1) measuring a urine sugar value A, (2) discriminating whether or not the measured urine sugar value is less than a discriminating method classification boundary value, (3) when it is less, obtaining an averaged value X of measured urine sugar values during a past predetermined period of time, measured at the same timing in a one-day life as the timing when the latest measured urine sugar value is measured, (4) calculating the difference between the averaged value and the measured urine sugar value, (5) when the difference is not less than a positive discriminating reference difference, discriminating as being a blood sugar value decrease, (6) when the measured urine sugar value A is not less than the discriminating method classification boundary value, obtaining an averaged value X of all measured urine sugar values during the past predetermined period of time, (7) calculating a ratio between the measured urine sugar value and the averaged value X, and, (8) when the ratio is not greater than a first discriminating reference ratio, discriminating as being the blood sugar value decrease.04-16-2009
20110196618METHOD FOR VERIFYING POSITION ON AN ANGIOPLASTY BALLOON - A monitoring system and data archive system for a stent crimping process. The information concerning the crimped stent is used in deciding whether the stent is acceptable for insertion into the body cavity of a human or animal.08-11-2011
20090150083ANALYZER, ANALYSIS METHOD AND COMPUTER PROGRAM PRODUCT - An analyzer includes a determining unit that determines whether an analysis result of a sample corresponding to a controlled specimen having a known value is normal or not based on an analysis result of the controlled specimen. The analyzer also includes a generating unit that generates analysis information in which a determination result by the determining unit is associated with each analysis result of samples; and an output unit that outputs the analysis information generated by the generating unit.06-11-2009
20110264374Method, Computer Program Product and System for Individual Assessment of Alcohol Sensitivity - Methods/computer methods and systems/computer systems for the evaluation of two idiosyncratic indices of alcohol intoxication: the Alcohol Sensitivity Index (ASI), and the brain-specific Cognitive Alcohol Sensitivity Index (CASI). The two indices are based on the new Metabolic and Cognitive Minimal Models of Alcohol Dynamics, and are derived from specific clinical protocols, accompanied by specific data analysis procedures. The two indices may be derived from specific clinical and cognitive assessment protocols, accompanied by specific data analysis procedures based on the new metabolic and cognitive minimal models of alcohol dynamics.10-27-2011
20110202286Optical System Determination According to Advanced Criteria - A method implemented by computer means for calculating by optimization an optical system for example an ophthalmic lens according to at least one criterion among the following list consisting of: ocular deviation, object visual angular field in central vision, image visual angular field in central vision, pupil field ray deviation, object visual angular field in peripheral vision, image visual angular field in peripheral vision, prismatic deviation in peripheral vision, magnification in peripheral vision, lens volume, magnification of the eyes, temple shift, or a variation of preceding criteria.08-18-2011
20100017143GESTATIONAL AGE DEPENDENT PROTEOMIC CHANGES OF HUMAN MATERNAL SERUM FOR MONITORING MATERNAL AND FETAL HEALTH - The present invention concerns a global maternal serum proteome map and its changes during healthy gestation. Accordingly, the present invention provides an important tool for plasma-based maternal-fetal diagnostics.01-21-2010
20120239304Method and System for Determining Analyte Levels - Methods and apparatus for analyte level estimation are provided.09-20-2012
20120035858DEVICE FOR ELECTRICALLY MEASURING AT LEAST ONE PARAMETER OF A MAMMAL'S TISSUE - The device measuring a parameter p that depends on the real and/or imaginary parts of the permittivity of body tissue operates at a frequency f where a temperature change affects the permittivity of free water only weakly. If the parameter p depends on the real part of the permittivity only, the frequency f should be between 6.2 and 10.1 GHz. If the parameter p depends on the imaginary part of the permittivity only, the frequency f should be between 25.5 and 36 GHz. If parameter p depends on the real and imaginary parts of the permittivity, the derivative of the parameter in respect to the real and imaginary parts of permittivity can be used to calculate an optimum frequency range.02-09-2012
20120035856METHOD FOR THE DISCOVERY, VALIDATION AND CLINICAL APPLICATION OF MULTIPLEX BIOMARKER ALGORITHMS BASED ON OPTICAL, PHYSICAL AND/OR ELECTROMAGNETIC PATTERNS - A method for determining multiplex biomarker algorithms based on optical, physical and/or electromagnetic patterns, and applying the multiplex biomarker algorithms so as to provide a single diagnostic result indicative of a medical condition, the method comprising: 02-09-2012
20120109532METHOD AND SYSTEM OF ANALYZING DYNAMIC PHENOMENA - A system and method are provided for measuring dynamic phenomena in a biological, chemical or physical sample, including the measurement of Ca05-03-2012
20120109535Gene Expression Profiles to Predict Relapse of Prostate Cancer - The present disclosure provides a method for cancer relapse prediction that provides higher resolution grading than Gleason score alone. In particular, the method provides for prediction of prostate cancer relapse that correlates gene expression of each individual signature gene and deriving a prostate cancer gene expression (GEX) score in the plurality of prostate cancer tissue samples; and correlating said GEX score with the clinical outcome for each prostate carcinoma tissue sample. A set of signature genes is provided that encompasses all or a sub-combination of GI_2094528, KIP2, NRG1, NBL1, Prostein, CCNE2, CDC6, FBP1, HOXC6, MKI67, MYBL2, PTTG1, RAMP, UBE2C, Wnt5A, MEMD, AZGP1, CCK, MLCK, PPAP2B, and PROK1.05-03-2012
20120109534AUTOMATIC ANALYZER AND ANALYSIS METHOD - In known automatic analyzers for detecting an abnormality by approximating reaction process data using a function, accuracy of detecting a reaction abnormality is degraded because of poor approximation accuracy depending on test items. Data processing means stores the absorbance and time of day at which the absorbance is measured as time-series data. Letting x denote absorbance, t denote time, and * denote a symbol representing multiplication, we have a function x=a05-03-2012
20120109533METHOD OF ANALYZING PROTEIN USING DATA-INDEPENDENT ANALYSIS COMBINED WITH DATA-DEPENDENT ANALYSIS - The present invention relates to a method of analyzing a protein or proteins comprising the steps of: (A) pre-treating a mixture containing at least one protein to obtain peptides; (B) obtaining information about retention times and mass values of the obtained peptides by performing data-independent analysis; (C) searching a first database on the basis of the information obtained in step (B) to quantify and qualify a target protein or proteins; (D) extracting information about the quantified and qualified target protein or proteins; (E) obtaining information about retention times and mass values by performing data-dependent analysis from the extracted information of step (D); (F) searching a second database on the basis of the information obtained in step (E) to further quantify and qualify the target protein or proteins; and (G) comparing the search results of step (C) and (F) to verify the quantification and qualification.05-03-2012
20120109531ANALYSIS SYSTEM FOR ANALYZING BIOLOGICAL SAMPLES - An analysis system for analyzing biological samples is disclosed, and which may comprise two or more analysis system components for performing an analysis. A sample workflow manager and an instrument manager coupled to the sample workflow manager may be coupled to the system components for receiving a process status from the system components, wherein the sample workflow manager provides at least one preconfigured processing route to the instrument manager in accordance with the process status. The instrument manager may comprise a memory for storing the preconfigured processing route, wherein the instrument manager is adapted for receiving a test order for analyzing the biological sample using the system components, and wherein the instrument manager is adapted for generating commands for controlling a transport device for transporting the biological sample in accordance with the test order and the at least one preconfigured processing route.05-03-2012
20120109530METHOD OF CLASSIFYING CHEMICALLY CROSSLINKED CELLULAR SAMPLES USING MASS SPECTRA - A method of analyzing cellular samples, particularly gastrointestinal cellular samples, that include a chemically crosslinked analyte is provided. The analysis typically involves the use of mass spectrometry. The methods described herein may be used to identify biomarkers associated with disease as well as to provide risk assessment for developing disease.05-03-2012
20120109529SAMPLE PROCESSING APPARATUS AND NON-TRANSITORY STORAGE MEDIUM - A sample processing apparatus includes: a first sample processing unit; a second sample processing unit; and a data processing unit connected to the first and the second sample processing units. The data processing unit includes: a display device; an input device; and a controller configured to show a screen image on the display device, wherein the screen image comprises a shared region which is shared for displaying information of each of the first and the second sample processing units, a first operation section operable by a user to control the first sample processing unit and a second operation section operable by the user to control the second sample processing unit, and control the first sample processing unit in response to an operation of the first operation section, and control the second sample processing unit in response to an operation of the second operation section.05-03-2012
20100121581Administering a therapeutic agent with more than one taggant - A system may include a means for administering a therapeutic agent to a subject; a means for administering a first pharmaceutically-acceptable taggant to the subject at least substantially concurrent with the therapeutic agent, the first pharmaceutically-acceptable taggant having a pharmacokinetic profile; and a means for administering a second pharmaceutically-acceptable taggant to the subject with the first pharmaceutically-acceptable taggant, the second pharmaceutically-acceptable taggant having a pharmacokinetic profile different from the pharmacokinetic profile of the first pharmaceutically-acceptable taggant.05-13-2010
20090093969Computer-Aided Discovery of Biomarker Profiles in Complex Biological Systems - The invention relates to computational methods, systems and apparatus useful in the analysis of sets of biomolecules in an accessible body fluid or tissue sample from a patient, which biomolecules collectively or individually are candidates to serve as biomarkers, i.e., biomolecules which together or individually upon detection or change are indicative that the patient is in some biological state, such as a diseased state. The methods permit one to examine such potential biological markers to determine whether each one is indeed present as a consequence of the biological state, or as an artifact of the biomarker search protocol.04-09-2009
20090093968ANALYSIS DEVICE AND ANALYSIS METHOD - In an analysis device for measuring a target substance in a liquid sample, highly precise measurement cannot be realized because reliability of measurement is degraded due to influences of properties of the liquid sample and an analysis element.04-09-2009
20080270038SYSTEM, APPARATUS AND METHOD FOR DETERMINING COMPATIBILITY BETWEEN MEMBERS OF A SOCIAL NETWORK - A system, apparatus, and method are provided to assist users to access and process information about a group of friends who are members of a third party social network in order to determine compatibility between the user and each friend or determine the most-compatible friends within that social network. In some embodiments, the system and method may obtain login or other authentication data regarding a user to access the user information on the third party social network, such as a list of friends (e.g., a buddy list) specified within the third party social network. After accessing the list of friends, information regarding each friend's preferences, interests, likes, dislikes, etc. may also be obtained from the third party social network. Subsequently, a compatibility measure between the user and each friend in the list is determined based on the obtained information regarding the friend and the user. The resulting compatibility measures may be filtered, sorted, ranked, or otherwise processed or acted upon prior to, or after presentation to the user.10-30-2008
20110125410SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.05-26-2011
20100088036Hair Coloring Method and Hair Coloring Selection Method - A method for hair coloring and selecting a hair colorant formulation based on hair type that minimizes variations in resultant hair color among different users having different hair types.04-08-2010
20110161011COMPUTER-ACCESSIBLE MEDIUM, SYSTEM AND METHOD FOR ASSESSING EFFECT OF A STIMULUS USING INTERSUBJECT CORRELATION - Exemplary embodiments of a system and method can be provided for measuring a level and/or details of how engaging, effective or memorable a stimulus that may be based on information associated with one or more subjects' neuronal, physiological and/or behavioral responses to the stimulus. In addition, an exemplary embodiment of a computer-accessible medium containing executable instructions thereon can also be provided which can be executed by a processing arrangement. For example, when the processing arrangement executes the instructions, the processing arrangement can be configured to, e.g., receive neuronal, physiological and/or behavioral data one or more subjects being presented with stimuli, determine further data associated with a measure of inter-subject similarity of the neuronal, physiological and/or behavioral data, and identify particular portions of the stimuli that meet a pre-determined criteria relating to the further data associated with the measure of inter-subject similarity. In addition, the processing arrangement can be further configured to display and/or store identifiers of the particular portions of the stimuli in a storage arrangement in a user-accessible format and/or a user-readable format.06-30-2011
20090248316METHOD FOR SUPPORTING A DIAGNOSIS OF AN EFFECT OF A TREATMENT BY USING ANTHRACYCLINE ANTICANCER DRUGS AND A DEVICE FOR SUPPORTING A DIAGNOSIS FOR AN EFFECT OF A TREATMENT BY USING ANTHRACYCLINE ANTICANCER DRUGS - A method of supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs is disclosed. The method provides a new value for judging an effect, a judgment score, which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The effect of the treatment by using anthracycline anticancer drugs is judged by comparing the judgment score with a predetermined threshold level.10-01-2009
20090099784SOFTWARE ASSISTED METHODS FOR PROBING THE BIOCHEMICAL BASIS OF BIOLOGICAL STATES - The present invention relates to computational methods, systems and apparatus useful in the identification of similarities and/or differences between a plurality of biological states, such as altered biological states in an animal (e.g., a mammal or human). Particularly, the invention relates to comparing two or more causal system models (“CSMs”) which each are indicative of a biological state, such as a disease state, a toxic state, or a drug- or therapy-induced state. The present invention also relates to generating a general CSM from a comparison of two or more other CSMs, and subsequently comparing one or more of the other CSMs to the general CSM. Either of these techniques, or a combination of the two techniques, can be used to identify unique and common features in each CSM.04-16-2009
20120143514Movement Monitoring Device For Action Sports, And Associated Methods - A movement monitoring device (MMD) for action sports has a detector for sensing motion associated with action sports, a processor for processing data from the detector to determine one or more movement metrics, and a communications port for wirelessly relaying the movement metrics to a remote location. A method collects motion data within action sports, including: detecting motion of a person or object engaged in action sports; determining one or more events associated with the motion; and wirelessly relaying the events to a remote network. One MMD for action sports is formed within a cell phone having a detector for sensing motion associated with action sports and a processor for processing data from the detector to determine one or more movement metrics for (a) display to a person using carrying the cell phone during action sports or (b) relaying the movement metrics to an external network for review by others.06-07-2012
20090204337Method for Identifying the Elution Time of an Analyte - A method for determining a time of elution of a peptide of interest from a liquid chromatography column includes a step of obtaining chromatographic data for each of a plurality of candidate fragment ions of the peptide of interest. A time along a common chromatographic time is scale determined corresponding to maximum overlay of the ion signals measured for each of the plurality of candidate fragment ions. Finally, the determined time is assigned as the time of elution of the peptide of interest from the liquid chromatography column. In particular, the chromatographic data is acquired during selective reaction monitoring of an eluate from the liquid chromatography column containing the peptide of interest. The chromatographic data includes ion signals measured along the common chromatographic time scale for each of the plurality of candidate fragment ions.08-13-2009
20100125416Blood Based Methods for Assessing Adolescent Depression in a Subject - The present invention provides blood based methods for assessing adolescent depression in a subject.05-20-2010
20100125420Food content detector - A system may include utensil means for portioning a foodstuff into a first portion and a second portion, a means for detecting a first portion size for the first portion with the utensil means, a means for detecting a second portion size for the second portion with the utensil means, and a means for determining a cumulative amount of portioned foodstuff based upon the first portion size and the second portion size.05-20-2010
20100125418Food content detector - A system may include utensil means for portioning a foodstuff into a first portion and a second portion, a means for detecting a first portion size for the first portion with the utensil means, a means for detecting a second portion size for the second portion with the utensil means, and a means for determining a cumulative amount of portioned foodstuff based upon the first portion size and the second portion size.05-20-2010
20090287418POPULATION OF BACKGROUND SUPPRESSION LISTS FROM LIMITED DATA IN AGENT DETECTION SYSTEMS - Methods and systems are disclosed for detection of agents such as pathogens or toxic substances and, in particular, to methods and systems for determining the most important background constituents to suppress in a sample, e.g., in a bulk aerosol sample, in order to reduce the probability of false alarms and improve the level of detection of potentially harmful airborne agents.11-19-2009
20090088981Methods And Systems Of Dynamic Screening Of Disease - The present invention provides methods and systems for dynamic screening of disease in a subject. The information provided by the methods and systems can be used for many purposes including disease diagnosis and screening, disease treatment, and education the subject of life choices.04-02-2009
20090292481APPARATUS, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR THERAPY PLANNING IN TREATMENT OF A PATIENT - An apparatus, method, system, computer-readable medium and use for individual patient therapy planning of diseases such as cancer for different therapy modalities, such as radiation therapy and chemotherapy is provided. A new aspect of the invention is that the degree of bone marrow depression of the patient is related to the count of immature blood platelets, which are measured before each treatment. Some embodiments of the invention provide an advantage allowing reducing the level of uncertainty in the prediction of the risk of bone marrow depression, and thus enabling to safely improve the therapy effect by an increase of the radiation dosage and/or chemical dosage to the individual patient while the risk for bone marrow depression is minimized.11-26-2009
20080208479Devices and Methods for Calculating and Communicating Differences in Measured Data - The current invention provides a measurement device having a data processing means that collects measurement data points, stores the collected measured data points and calculates differences and changes in said measurement data points. The device communicates these changes in measured data points to the user. The device does not communicate the measured value to a user. Also provided is a method for monitoring changes in measured data.08-28-2008
20080208480INFORMATION MANAGEMENT SYSTEM AND INFORMATION MANAGEMENT SERVER - For the purpose of effectively supervising a user of the health indexes that cannot always be measured, such as the weight and blood pressure, warning and information are provided based on a prediction of the health indexes. In an information management system, in which a first parameter that is not always measured is predicted from a second always measurable parameter.08-28-2008
20110172928MOLECULAR MARKERS FOR CANCER PROGNOSIS - The present invention relates to methods for prediction of an outcome of neoplastic disease or cancer. More specifically, the present invention relates to a method for the prediction of breast cancer by determining in a biological sample from said patient an expression level of a plurality of genes selected from the group consisting of ACTG1, CA12, CALM2, CCND1, CHPT1, CLEC2B, CTSB, CXCL13, DCN, DHRS2, EIF4B, ERBB2, ESR1, FBXO28, GABRP, GAPDH, H2AFZ, IGFBP3, IGHG1, IGKC, KCTD3, KIAA0101, KRT17, MLPH, MMP1, NAT1, NEK2, NR2F2, OAZ1, PCNA, PDLIM5, PGR, PPIA, PRC1, RACGAP1, RPL37A, SOX4, TOP2A, UBE2C and VEGF.07-14-2011
20110270529SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR MANAGING A RESEARCH SEED LOCATION - The present invention provides a system, method and computer program product for managing a research seed location. In various embodiments, the method of the present invention comprises storing at least one field characteristic layer in a memory, storing at least one the research plot layer in a memory, and merging the research plot layer and the field characteristic layer via a processor. In some embodiments, the research plot plan may be linked to a research plot database. In some embodiments, plant observation data and/or plant harvest data may be collected and may be merged with the research plot plan. In some embodiments, a seed planting device may be controlled to plant seeds according to the research plot plan.11-03-2011
20100100332DETERMINATION OF MELTING TEMPERATURES BY EQUATION-LESS METHODS - Numerical determinations of the first derivatives of a melt curve data set are made. A model function, such as a Gaussian Mixture Model (GMM) function, with parameters determined using a Levenberg-Marquardt (LM) regression process is used to find an approximation to the first derivative curve. The maximum values of the numerically determined first derivative values are used as initial conditions for parameters of the model function. The determined parameters provide one or more fractional melting temperature values, which can be returned, for example, displayed or otherwise used for further processing.04-22-2010
20100100331SYSTEMS AND METHODS FOR BIOPOLYMER ENGINEERING - Methods, computer systems, and computer program products for biopolymer engineering. A variant set for a biopolymer of interest is constructed by identifying, using a plurality of rules, a plurality of positions in the biopolymer of interest and, for each respective position in the plurality of positions, substitutions for the respective position. The plurality of positions and the substitutions for each respective position in the plurality of positions collectively define a biopolymer sequence space. A variant set comprising a plurality of variants of the biopolymer of interest is selected. A property of all or a portion of the variants in the variant set is measured. A sequence-activity relationship is modeled between (i) one or more substitutions at one or more positions of the biopolymer of interest represented by the variant set and (ii) the property measured for all or the portion of the variants in the variant set. The variant set is redefined to comprise variants that include substitutions in the plurality of positions that are selected based on a function of the sequence-activity relationship.04-22-2010
20110172927AUTOMATED ADJUSTMENT OF POSTURE STATE DEFINITIONS FOR A MEDICAL DEVICE - Techniques relate to operating a medical device by classifying a detected posture state of a patient. This classification may be performed by comparing the detected posture state of the patient to posture state definitions available within the system. Each definition may be described in terms of a parameter (e.g., vector) indicative of a direction in three-dimensional space. The posture state definitions may be calibrated by automatically estimating values for these parameters, thereby eliminating the need for the patient to assume each posture state during the calibration process to capture actual parameter values. According to another aspect, the estimated parameter values may be updated as the patient assumes various postures during a daily routine. For instance, estimated vectors initially used to calibrate the posture state definitions may be changed over time to more closely represent posture states the patient actually assumes, and to further adapt to changes in a patient's condition.07-14-2011
20110172926Generating, viewing, interpreting, and utilizing a quantitive database of metabolites - This disclosure provides methods for the creation of a quantitative database of metabolites, particularly lipid metabolites, using chromatographic technology; methods for assembling that information into a visual format for interpretation, and methods of this information to identify and understand metabolome-wide effects, for instance those effects influenced by pharmaceuticals, genes, toxins, diet or the environment. Also provided are metabolite databases, such as lipid metabolite databases, that are stored on a computer readable medium, which include quantitative measurements of a plurality of metabolites.07-14-2011
20110172925Secondary Structure Defining Database And Methods For Determining Identity And Geographic Origin Of An Unknown Bioagent Thereby - The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.07-14-2011
20090287417Method for Detecting a Biochemical Interaction - A method for detecting a biochemical interaction between at least two interaction partners, comprising the steps of bringing into contact the at least two interaction partners, taking a temporal sequence of measurements, each of them producing a measurement value describing the state of the interaction at a given point in time, adapting a mathematical model to the temporal sequence of measurements, whereby the model contains at least one first parameter characterising a temporal phase of increasing measurement values and at least one second parameter characterising a temporal phase of decreasing measurement values, and detecting the biochemical interaction by evaluating the first and second parameter.11-19-2009
20090292479METHOD FOR ANALYZING IMAGE FROM BIO-DETECTION ANALYZER - A method for analyzing an image from a bio-detection analyzer includes steps of: illuminating a reacted bio-detection carrier having at least one detection spot and at least one positioning spot by at least one light source; capturing a single image of the bio-detection carrier having all of detection-spot images and positioning-spot images by an image capturing unit; defining a reference coordinate location of each of the detection-spot images according to the positioning-spot image; defining an effective detection area of each of the detection-spot images according to the reference coordinate location of each of the detection-spot images; and analyzing an averaged intensity value (such as an averaged gray scale value) of each of the detection-spot images, so as to output the averaged intensity value for showing a reaction result of the reacted bio-detection carrier.11-26-2009
20090299649Hydropathy Plots and Fourier Analysis with Ellipsoidal Distance Metric - Techniques for protein structure analysis are provided. In one aspect, an article of manufacture for characterizing at least a portion of a protein structure comprising amino acid residues is provided. A set of values characterizing the protein structure are determined, wherein each value represents a distance from a center of the protein structure to a center of a given one or more of the amino acid residues. One or more other sets of values characterizing the hydrophobicity of the protein structure are obtained. A Fourier transform is performed on each of the sets of values to obtain transformed values sets. The transformed value sets are compared to correlate the hydrophobicity with the protein structure.12-03-2009
20090299646System and method for biological pathway perturbation analysis - The invention provides system and methods for analyzing the perturbation of one or more biological pathways. In one embodiment, expression values for each of a plurality of genes for one or more experimental conditions may be received. Gene differential regulation values may then be calculated for each of the plurality of genes across each of the one or more experimental conditions. The gene differential regulation values may then be grouped by the biological pathway and experimental condition from which each gene differential regulation value originated yielding one or more pathway-condition data sets. Pathway perturbation values may then for each of the one or more pathway-condition data sets using the gene differential regulation values. These pathway perturbation values may be clustered, used to identify biological pathways or experimental conditions for further analysis, and/or utilized to build a classifier for classifying additional experimental data.12-03-2009
20130218475Computer Systems for Treating Diseases - The present invention relates to computer-implemented methods and system for analysing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analysing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.08-22-2013
20130218473FREQUENCY SHIFT DETECTOR - A frequency shift detector includes a digital control unit, a digital/analog converter, a reagent concentration detecting circuit and a frequency difference generator, wherein the digital control unit includes a control circuit and a direct digital frequency synthesizer electrically connected with the control circuit, and the control circuit comprises a reset terminal and a pulse input terminal. The digital control unit proceeds with accurate concentration detection for various samples borne on the reagent concentration detecting circuit.08-22-2013
20110208439METHODS FOR MEASURING THE MAGNITUDE OF ATTENTION AND MOTOR ACTIVITY DISTURBANCE IN A SUBJECT - The invention features methods and systems to monitor changes in the magnitude of attentional disturbance and the magnitude of motor activity disturbance in a subject. The invention also features methods and systems for determining a subject's degree of concordance with individuals having an attentional disorder versus individuals not having an attentional disorder. The methods and systems of the invention can enable clinicians and consumers to ascertain both the severity of an attentional disorder as well as how much an individual changes over time, or with therapy.08-25-2011
20110208434METHOD AND SOFTWARE FOR CARDIOVASCULAR ASSESSMENT AND RISK DETECTION - The present invention provides an improved comprehensive method of assessing an individual's risk of developing CVD through analysis of multiple factors know to be associated with the development of cardiovascular disease. The factors include the classic Framingham factors of an individual's age, blood pressure, total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, history of diabetes and history of cigarette smoking, in addition to factors know to be associated with increased risk of CVD including inflammation, insulin resistance, obesity, kidney dysfunction.08-25-2011
20100280761METHOD AND DEVICE FOR DETERMINING THE TRANSMEMBRANE PRESSURE IN AN EXTRACORPOREAL BLOOD TREATMENT - A method and device are provided for determining the transmembrane pressure during an extracorporeal blood treatment in which blood flows at a defined blood flow rate through an arterial blood conduit of an extracorporeal blood circuit into the inlet of a first chamber of a dialyzer, which is divided by a semipermeable membrane into the first chamber and a second chamber, and flows through a venous blood conduit from the outlet of the first chamber of the dialyzer, while dialysis liquid flows through a dialysis liquid supply conduit into the inlet of the second chamber of the dialyzer and flows through a dialaysis liquid discharge conduit from the outlet of the second chamber of the dialyzer. The method and the device for determining the transmembrane pressure are such that the pressure on the blood side and on the dialysis liquid side of the dialyzer is measured with relatively little technical outlay, specifically with fewer than four pressure sensors, and a preliminary uncorrected value is calculated for the transmembrane pressure and is thereafter corrected by a correction variable that is dependent on a variable correlating with the viscosity of the blood.11-04-2010
20080243395IMAGE DIAGNOSIS SUPPORTING APPARATUS AND SYSTEM - In a disease case DB, disease case images are classified by disorder and registered. In a feature quantity DB, a feature quantity (second feature quantity) of each disease case image classified by disorder is registered. A server compares a feature quantity (first feature quantity) of a lesion site included in a diagnosis target image, with the second feature quantity on a disorder-by-disorder basis, retrieves representative disease case images based on a comparison result from the disease case DB on a disorder-by-disorder basis, and provides a user with retrieved representative disease case images. Therefore, the user can obtain disease case images useful for determining a disorder or statistical information and the like regarding the disorder during image diagnosis based on the diagnosis target image.10-02-2008
20080243394SYSTEM, METHOD AND COMPUTER PROGRAM PRODUCT FOR MANIPULATING THERANOSTIC ASSAYS - A theranostics technique for describing signaling pathway activity within a cellular or tissue sample may include analyzing a cellular sample to obtain sample quantitative values for a series of target protein modification levels reflected in a set of a plurality of protein biomarkers in the sample. The sample quantitative values may be compared to reference quantitative values for the same series of protein modification levels. The reference quantitative values may be statistically processed from a plurality of comparable samples. The sample quantitative values may be displayed in relation to the reference quantitative values in a way that may suggest a specific course of treatment.10-02-2008
20110208436METHOD OF PERFORMING A SERIES OF EXPERIMENTS, AN INTEGRATED CONTINUOUS PHARMACEUTICAL PRODUCT PROCESSING SYSTEM, AND A COMPUTER PROGRAM PRODUCT - In the method, a series of experiments is performed in order to explore a set of process parameter ranges and/or a set of ingredient ranges of a pharmaceutical processing system. The method comprises step 08-25-2011
20110208437METHOD AND APPARATUS FOR IDENTIFYING A SAFE AND EFFICACIOUS DOSING REGIMEN - The invention features methods and systems to provide, in one test session, information on the patient's sensitivity to a probe drug for treating attentional disorders. The methods and systems of the invention can enable clinicians and consumers to ascertain how much benefit an individual would derive from treatment, what dose would be required, and the acute effect of that dose on regularity and rhythmicity of their heartbeat.08-25-2011
20110208432SYSTEMS AND METHODS FOR PRESUMPTIVE IDENTIFICATION OF MICROORGANISM TYPE IN A CULTURE - Systems, methods and apparatus for identifying a microorganism type in a culture are provided. A normalization relative value is calculated for each respective measurement of a biological state of the culture between (i) the respective measurement and (ii) an initial biological state. For each fixed interval of time points, a first derivative of the normalization relative values in the interval of time points is calculated, thereby forming a plurality of rate transformation values. For each respective set of rate transformation values in the plurality of rate transformation values, a measure of central tendency of the rate transformation values in the set is computed, thereby forming a plurality of average relative transformation values. A maximum metabolic rate and an extent of growth, determined from the normalization relative values and the average relative transformation values, are compared against a lookup table that matches these values to a microorganism type.08-25-2011
20080275651METHODS FOR INFERRING THE PRESENCE OF A PROTEIN IN A SAMPLE - A method of inferring presence of at least one protein in a sample includes entering a peptide training data set into a statistical inference model. The method further includes training the statistical inference model with the peptide training data set. The method further includes determining predicted detectability of at least one peptide present in the sample with the trained statistical inference model. The method further includes inferring the presence of the at least one protein in the sample based upon the determined predicted detectability. Methods for quantifying proteins present in a sample are also disclosed.11-06-2008
20090099785INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND STORAGE MEDIUM - An information processing apparatus includes a management section configured to manage biological rhythm information about a user, and a display control section configured to display the biological rhythm information so as to be associated with an object corresponding to the user.04-16-2009
20090099786BIOPOLYMER SEQUENCING BY HYBRIDIZATION OF PROBES TO FORM TERNARY COMPLEXES AND VARIABLE RANGE ALIGNMENT - Methods for sequencing a biopolymer by forming local ternary complexes along the length of the double-stranded biopolymer target molecule using one or more probes and obtaining information about the location of the probe(s) using a detector. These methods offer particular advantage when implemented with nanopore (including micropore) detection systems.04-16-2009
20100274499NUCLEIC ACID AMPLIFICATION DETERMINING METHOD AND NUCLEIC ACID AMPLIFICATION DETERMINING DEVICE - The present invention provides an amplification determining method that can determine whether or not an objective nucleic acid has been amplified with respect to a sample treated so as to amplify the nucleic acid. Signal values showing molten states of the treated sample at respective temperatures are provided, and the maximum signal value (A) is searched for. Further, signal differential values at the respective temperatures are calculated by differentiation of the signal values at two successive points, and second-order differential values of the differential values are calculated by differentiation at four successive points. Among the second differential values, from those in a predetermined temperature range including a Tm value of the objective nucleic acid, the maximum second differential value (D10-28-2010
20120143513BIO-SENSOR CHIP AND READER THEREOF - Provided are a bio sensor chip and a reader thereof. The bio-sensor chip is optically addressed. The bio-sensor chip includes a word line control circuit and a bit line control circuit controlled by light provided from the bio-sensor chip reader. The bio-sensor chip does not require a peripheral circuit for driving word lines and bit lines, simplifying a fabrication process and reducing the area of the chip.06-07-2012
20080281526Methods For Molecular Toxicology Modeling - The present invention is based on methods of predicting toxicity of test agents and methods of generating toxicity prediction models using algorithms for analyzing quantitative gene expression information. The invention also includes computer systems comprising the toxicity prediction models, as well as methods of using the computer systems by remote users for determining the toxicity of test agents.11-13-2008
20080281529GENOMIC DATA PROCESSING UTILIZING CORRELATION ANALYSIS OF NUCLEOTIDE LOCI OF MULTIPLE DATA SETS - Processing of genomic data is facilitated utilizing correlation analysis of mapped data sets, each data set including genomic data mapped and ordered relative to a genomic coordinate system. Correlation analysis identifies at a nucleotide level nucleotide positions wherein at least one nucleotide locus of each data set correlate. The analysis includes for each data set, selecting a nucleotide locus thereof closest to one end of the coordinate system, comparing the selected nucleotide loci for correlation, and if so, outputting results of the comparing, and updating the selected nucleotide loci by identifying the data set having a next nucleotide locus closest to the one end of the coordinate system, and inserting that next locus into the group of selected loci, and repeating the comparing for the newly selected loci. The process is repeated until nucleotide loci of the mapped data sets are compared and results of the comparison are output.11-13-2008
20080281527Microarray analytical data stitching system and method - A technique is provided for analyzing image data for biological microarrays. Images are made of multiple swaths in multiple passes of an imaging system. Sites encoded by the image data are assigned a value and these values are indexed by site location. An overlapping region of the swaths may be identified by analysis of the indexed site values. The site values for all image sites are then stitched and the data is integrated and stored for later analysis.11-13-2008
20080228405Search Space Coverage With Dynamic Gene Distribution - A method and apparatus for selecting measurements from a plurality of measurements is disclosed. The method includes the steps of initializing a measurement status to a first value for each of the measurements, determining selectability of one of the plurality of measurements based on a corresponding status value, and updating the status to a second value after selecting the measurement. In one aspect of the invention, the step of determining selectability further comprises the step of selecting one of the plurality of measurements, and retaining the selected measurement when the value of the corresponding status is the first value.09-18-2008
20080228408Method for Determining the State of an Ensemble of Cells and System for the Implementation of the Method - The invention concerns a method for determining the condition of at least one culture of prokaryotic or eukaryotic cells defined in greater detail herein, including in particular one or more steps for simultaneously analyzing the condition of a large number of biological markers of interest. The inventive method, enables, in some cases, the cellular response to a plurality of modifications of environmental conditions to be simultaneously determined, including, for example, the simultaneous determination of the cellular response to various compounds to be tested.09-18-2008
20080228407Method for Protein Structure Alignment Using Cellular Automata - The detection of protein sequence alignments firstly generates protein blocks having n successive C-alpha atoms from two protein sequences. A matrix of the distance of protein atoms from said C-alpha atoms for each block is then determined. A difference matrix is determined from respective distance matrices representing the differences between the protein blocks of the two protein structures. A Cellular Automaton (CA) model is generated in an initial configuration based upon the difference matrix, and evolved through at least one generation using predetermined rules. The rules determine which CA cells remain live and which are set to be dead.09-18-2008
20080228404Systems and methods for high-speed image scanning - Systems and methods for high-speed image scanning are disclosed herein One aspect of the invention is directed to a method for high speed image scanning. The method for high speed image scanning includes adjusting an object using a positioning element; directing a portion of an image of the object toward a sensor by positioning a first mirror relative to the object, and by positioning a second mirror relative to the object and the first mirror; controlling the positioning element, the position of the first mirror and the position of the second mirror using a processor; and detecting the portion of the image of the object using the sensor positioned relative to the first mirror and the second mirror. In accord with this method, the first mirror directs the portion of the image of the object in a first direction and the second mirror directs the portion of the image of the object in a second direction.09-18-2008
20080288175INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND PROGRAM - An information processing apparatus is disclosed which processes information about a network including a plurality of nodes representative of cellular molecules, the information processing apparatus including a detection section configured to detect from the network a node group corresponding to a switch pattern including at least two nodes potentially constituting a candidate of a molecular switch.11-20-2008
20100036616Normalization of Gene Expression Data - A method for determining bias across two domains comprising gene expression data. The method can comprise (a) providing a first domain and a second domain; (b) obtaining information indicative of a bias within the first domain; (c) obtaining information indicative of a bias within the second domain; and (d) using the information indicative of the bias within the first domain and the information indicative of the bias within the second domain to produce an indication of bias across the two domains.02-11-2010
20090265115METHOD AND APPARATUS FOR ANALYZING DNA - This invention is directed to a protocol and design for an apparatus to analyze the distribution and/or ratio of Thymine, Cytosine, Adenine and Guanine of a DNA sequence from a target organism. The result is then used to determine the possible impact the target organism may have in a host such as a human body. The goal is to provide an effective way to diagnose diseases such as infectious diseases, to test the safety of food and drugs, and therefore to create natural and effective solutions for health care and food supply. For example, a DNA analysis method configured according to the invention receives a DNA sequence input and converts it into a reassembled sequence. A result based on the reassembled sequence may then be output.10-22-2009
20100280760BIOMARKERS FOR MONITORING TREATMENT OF NEUROPSYCHIATRIC DISEASES - Methods for identifying and measuring pharmacodynamic biomarkers of neuropsychiatric disease, and for monitoring a subject's response to treatment. For example, materials and methods for monitoring the effectiveness of transcranial magnetic stimulation in a subject having a neuropsychiatric disease are provided.11-04-2010
20090265113SYSTEM AND METHOD FOR TESTING HEAT EXCHANGE SYSTEM FOR HEAT EXCHANGE CATHETER - A heat exchange system for an indwelling catheter is tested for proper operation by observing whether a fluid temperature is within a command zone range and if not whether temperature moves toward the range or equalizes with it within predetermined parameters after a pump has stopped, and only if temperature exhibits none of the tested-for conditions indicating an error.10-22-2009
20090265112Device and method for responding to influences of mind - In the field of direct mind-machine interactions, prior art devices and methods do not provide sufficiently fast and reliable results. Mental influence detectors (10-22-2009
20080312840Method for Affinity Scoring of Peptide/Protein Complexes - The present invention is related to a quantitative structure-based affinity scoring method for peptide/protein complexes. More specifically, the present invention comprises a method that operates on the basis of a highly specific force field function (e.g. CHARMM) that is applied to all-atom structural representations of peptide/receptor complexes. Peptide side-chain contributions to total affinity are scored after detailed rotameric sampling followed by controlled energy refinement. The method of the invention further comprises a de novo approach to estimate dehydration energies from the simulation of individual amino acids in a solvent box filled with explicit water molecules and applying the same force field function as used to evaluate peptide/receptor complex interactions.12-18-2008
20080312842Method and apparatus for providing data processing and control in a medical communication system - Methods and apparatus for providing data processing and control for use in a medical communication system are provided.12-18-2008
20120296569METHOD AND SYSTEM FOR WEIGHTED ANALYSIS OF NEUROPHYSIOLOGICAL DATA - A method of analyzing neurophysiological data is disclosed. The method comprises: identifying activity-related features in the data, constructing a brain network activity (BNA) pattern having a plurality of nodes, each representing a feature of the activity-related features, and assigning a connectivity weight to each pair of nodes in the BNA pattern.11-22-2012
20080201082Blood image analyzer - A blood image analyzer is disclosed that comprising: an image capturing unit for capturing a blood image of a sample; an analyzing part for analyzing the sample based on the blood image; an identification information reader for reading, from the sample, identification information assigned to the sample; a transportation part for transporting the sample to the identification information reader and the image capturing unit; a first detector for detecting the sample at a first detection position on a pathway of the sample transported by the transportation part; a display; and a controller for controlling the display, so as to display, based on a detection result by the first detector, a screen including a first identification information display region, wherein the first identification information display region displays identification information of the sample being at the first detection position.08-21-2008
20120296571ORGANISM INFORMATION MEASURING INSTRUMENT, PORTABLE TERMINAL DEVICE, ORGANISM INFORMATION MEASURING METHOD, AND PROGRAM - An organism information measuring instrument of the present invention includes: a sensor that measures organism information; a normalization circuit that normalizes the organism information by converting a value of the organism information based on preset normalization information; and a reliability information generation circuit that detects a change amount greater than or equal to a predetermined value in a predetermined time period, with respect to the organism information or the normalized organism information, and generates reliability information indicating lower reliability as the change amount is greater.11-22-2012
20080208481AUTOMATIC ANALYZER - The automatic analyzer is provided with a function of, based on selection of the output result targeted by a user from among all printed results output by the automatic analyzer, proceeding to a start page of the targeted output result so that the targeted output result is displayed, on a screen for displaying a list including a title of printing, the date of printing, a range of pages, and a user's check indicating whether or not the user has checked the result. The automatic analyzer is also provided with a function of enabling a user to add a check indicating whether or not the verification/confirmation of data has been performed, the check date, a checker, a comment, and the like, to the measurement result targeted by the user, and the like, on a screen displaying the result.08-28-2008
20090150081Automatic analyzer for enzyme immunoassays - An automatic analyzer for enzyme immunoassays, of the type that comprises a serum dispensing assembly, a reagent dispensing assembly, an incubation assembly, a washing assembly, a reader assembly and a data processing and storage assembly. The analyzer comprises a unit for containing at least one well for performing analyses on a serum and at least one test-tube which contains a respective reagent; the unit is accommodated detachably within a respective internal frame of the analyzer. The reagent dispensing assembly, the incubation assembly, the washing assembly and the reader assembly can move from a first configuration of maximum distance from the unit accommodated in the frame to a second configuration of substantial overlap with at least one portion of the unit.06-11-2009
20080270039METHOD AND DEVICE FOR PREDICTING PHYSIOLOGICAL VALUES - The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.10-30-2008
20080270037System and method for measuring and displaying health information - A system and method are provided for measuring and displaying health information. The system includes a measurement platform for performing one or more health information measurements, a terminal device for displaying the measurement results, and a portable storage device for storing the measurement information and user data. Push-pull output logic is used to provide for an efficient supply of power and to eliminate the consumption of power by the terminal device at the time of a signal input.10-30-2008
20100145627SYSTEM WITH EXTENDED RANGE OF MOLECULAR SENSING THROUGH INTEGRATED MULTI-MODAL DATA ACQUISITION - A multi-modal data acquisition system for detecting target material on a biological reaction surface, the system comprising a radiation source for generating an incoming beam that impinges on the biological reaction surface at an oblique incidence angle and produces a reflected beam, an interferometric detector for detecting an interferometric signal from the illuminated surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated surface; the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam; and a processing system for receiving the interferometric and fluorescence signals and determining the presence or absence of target material on the biological reaction surface. A reaction surface conditioned for the simultaneous collection of fluorescence, interferometric and other signals. A multi-modal data acquisition system for collecting and processing additional modes, including multiple interferometric, fluorescence and scattering channels.06-10-2010
20100145623Methods and systems for using ultraviolet index data in plant evaluation applications - Methods and systems for using UVI data in plant evaluation applications avail themselves of the correlation between PAR and UVI to estimate PAR based on UVI and apply the PAR estimate in a plant evaluation application, such as a plant selection or plant heath diagnostics application. A UVI-based PAR estimate may be used, for example, to dramatically reduce the time that an environmental probe must be deployed at a plant site by normalizing a sensor-based PAR estimate generated from short-term measurements taken by the environmental probe to produce a faster, more accurate and more reliable plant evaluation.06-10-2010
20100145625DETERMINATION AND PREDICTION OF THE EXPRESSION OF TRAITS OF PLANTS FROM THE METABOLITE PROFILE AS A BIOMARKER - The present invention relates to a method for determining the correlation between the metabolite profiles (MPs) and the expression or potential for expression of a trait of a group of plants, and further to a method for determining or predicting the expression of a trait of a plant by taking advantage of the determined MP of said plant and a determined correlation between the MPs and the expression or potential for the expression of said trait in a group of plants.06-10-2010
20090099780HEALTHCARE DEVICE AND COMPREHENSIVE MEASUREMENT METHOD USING THE SAME - A healthcare device and a method using the same are disclosed. The healthcare device includes a biological data measuring module, a conversion module for amplifying data measured by the biological data measuring module by using a non linear function, a biological data input module for inputting a conversion data converted by said conversion module or for inputting a measuring data measured by a Chinese or a western medical device, a healthcare classification module for generating different healthcare classification data according to comparison of data inputted by the biological data input module, and a biological performance module for converting the classified healthcare clue into an energy distribution data or a mentality level data by using a non linear function.04-16-2009
20080234943COMPUTER PROGRAM FOR DIABETES MANAGEMENT - A diabetes management system or process is provided herein that may be used to analyze and recognize patterns for a large amount of blood glucose concentration measurements and other physiological parameters related to the glycemia of a patient. In particular, a method of monitoring glycemia in a patient may include storing a patient's data on a suitable device, such as, for example, a glucose meter. The patient's data may include blood glucose concentration measurements. The diabetes management system or process may be installed on, but is not limited to, a personal computer, an insulin pen, an insulin pump, or a glucose meter. The diabetes management system or process may identify a plurality of pattern types from the data including a testing/dosing pattern, a hypoglycemic pattern, a hyperglycemic pattern, a variability pattern, and a comparative pattern. After identifying a particular pattern with the data management system or process, a warning message may be displayed on a screen of a personal computer or a glucose meter. Other messages can also be provided to ensure compliance of any prescribed diabetes regiments or to guide the patient in managing the patient's diabetes.09-25-2008
20100145624STATISTICAL VALIDATION OF CANDIDATE GENES - Provided herein are methods for evaluating associations between candidate markers and a trait of interest in a plant population. In various embodiments, the plant population is a breeding population, particularly early stage breeding populations. The methods include obtaining a genotypic value for candidate markers and correlating the marker with the trait. Various association models can be used to evaluate the association, and include statistical methods relevant to the structure of plant breeding populations. Population structure may be accounted for in the association models by using Principle Component Analysis. Further provided is a novel statistical approach for association mapping in early stage breeding materials using a transmission disequilibrium based methodology. Markers identified using the methods of the invention can be used in marker assisted breeding and selection, for constructing genetic linkage maps, to identify genes contributing to a trait of interest, and for generating transgenic plants having a desired trait.06-10-2010
20090119020PCR ELBOW DETERMINATION USING QUADRATIC TEST FOR CURVATURE ANALYSIS OF A DOUBLE SIGMOID - Systems and methods for determining whether the data for a growth curve represents or exhibits valid or significant growth. A data set representing a sigmoid or growth-type curve, such as a PCR curve, is processed to determine whether the data exhibits significant or valid growth. A first or a second degree polynomial curve that fits the data is determined, and a statistical significance value for the curve fit is determined. If the significance value exceeds a significance threshold, the data is considered to not represent significant or valid growth. If the data does not represent significant or valid growth, the data set may be discarded. If the significance value does not exceed the significance threshold, the data is considered to represent significant or valid growth. If the data set is determined to represent valid growth, the data is further processed to determine a transition value in the sigmoid or growth curve, such as the end of the baseline region or the elbow value or Ct value of a PCR amplification curve.05-07-2009
20110208438SYSTEM FOR AUTOMATICALLY TESTING A FLUID SPECIMEN - A system for automatically testing a fluid specimen, e.g., urine, to indicate the presence of specified chemical components in the specimen. The system preferably utilizes an assaying device comprised of a collection cup and a cap which carries at least one test strip. The device includes an integrated aliquot delivery mechanism actuatable to wet the test strip with an aliquot delivered from the fluid specimen. The assaying device is configured to operate in conjunction with an electronic reader device capable of actuating the aliquot delivery mechanism and reading the reaction of the test strip. A preferred reader device defines a keyed receptacle for accommodating a complementary shaped cup housing in a particular orientation. The reader device is comprised of a camera for capturing the image of a test strip, an actuator for actuating an aliquot delivery mechanism, and a microprocessor/controller for (1) controlling the camera and actuator and (2) processing the image.08-25-2011
20110208435CAPACITANCE DETECTION IN ELECTROCHEMICAL ASSAYS - A method and system are provided to determine fill sufficiency of a biosensor test chamber by determining capacitance of the test chamber.08-25-2011
20090112478Modified Sensor Calibration Algorithm - A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals, obtaining reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals, calculating the calibration characteristics using the reference glucose values and corresponding glucose monitor data to regress the obtained glucose monitor data, and calibrating the obtained glucose monitor data using the calibration characteristics. In additional embodiments, calculation of the calibration characteristics includes linear regression and, in particular embodiments, least squares linear regression. Alternatively, calculation of the calibration characteristics includes non-linear regression. Data integrity may be verified and the data may be filtered. Further, calibration techniques may be modified during a fast rate of change in the patient's blood glucose level to increase sensor accuracy.04-30-2009
20090138203SYSTEMS AND METHODS FOR USING MOLECULAR NETWORKS IN GENETIC LINKAGE ANALYSIS OF COMPLEX TRAITS - The present disclosed subject matter relates to methods of using molecular networks in whole genome genetic linkage analysis of complex inherited disorders, including determining gene-specific linkage probability values for one or more genes represented in a predetermined molecular interaction network. The present disclosed subject matter further relates to methods of identifying one or more gene that is associated with one or more heritable diseases, and methods of diagnosing the heritable diseases.05-28-2009
20090119021METHOD AND APPARATUS FOR DETERMINING AND DISPLAYING MEDICAL INFORMATIONS - The invention relates to a method for determining and displaying medical informations, in which rough measurement data collected with the aid of different medical measuring methods in at least one measurement interval on the same test subject are stored and in which evaluation data are extracted from the rough measurement data. Further for generating medical informations for at least two selected measuring methods from among the different medical methods, the evaluation data extracted from the in each case associated rough measurement data of a measurement interval are interlinked and for the at least one measurement interval the linked evaluation data are processed as medical informations for outputting on a graphic output device. The invention also relates to an apparatus for performing this method.05-07-2009
20090177405METHOD, A COMPUTER PROGRAM AND A COMPUTER SYSTEM FOR DETERMINATION WHETHER A SUBJECT HAS AN INCREASED RISK FOR ACQUIRING A DISEASE - A method, a computer program and a computer system are described for determining whether a subject has an increased risk for acquiring a disease, said method comprising selecting at least one disease, for example using a user interface wherein in a field 07-09-2009
20120197533IDENTIFYING REARRANGEMENTS IN A SEQUENCED GENOME - Methods, apparatuses, and systems for identification of junctions (e.g., resulting from large-scale rearrangements) of a sequenced genome with respect to a human genome reference sequence is provided. For example, false positives can be distinguished from actual junctions. Such false positives can result from many sources, including mismapping, chimeric reactions among the DNA of a sample, and problems with the reference genome. As part of the filtering processes, a base pair resolution (or near base pair resolution) of a junction can be provided. In various implementations, junctions can be identified using discordant mate pairs and/or using a statistical analysis of the length distributions of fragments for local regions of the sample genome. Clinically significant junctions can also be identified so that further analysis can be focused on genomic regions that may have more of an impact on the health of a patient.08-02-2012
20090187351ANALYTE TESTING METHOD AND SYSTEM - Described and illustrated herein is an exemplary method of operating an analyte measurement device having a display, user interface, processor, memory, and user interface buttons. Such method can be achieved by measuring an analyte with the analyte measurement device, displaying a value representative of the analyte, prompting a user to select a flag to associate the flag with the value, and pressing only one of the user interface buttons once to store the flag with the value in the memory of the analyte measurement device. In one embodiment, the testing device is a glucose meter and the analyte being tested is glucose.07-23-2009
20090138208IMMUNOGLOBULIN G BINDING POCKET - The present invention relates to a human IgG binding pocket comprised of a first interacting surface, which originates from an IgG κ light chain, and a second interacting surface, which originates from an IgG heavy chain, which amino acids are strictly conserved between human IgGs of κ-type. The invention also embraces an isolated and purified polypeptide, which comprises said binding pocket. Further, the invention relates to various methods of using the novel binding pocket, such as in screening for identification of chemical entities capable of selective binding thereof, and in other experimental and/or virtual methods for design and/or identification of chemical entities capable of selective binding thereof.05-28-2009
20090138205OPTIMIZED METHOD FOR LID BIOSENSOR RESONANCE DETECTION - An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.05-28-2009
20130218477METHOD FOR EVALUATING THE QUANTITY OF METHANE PRODUCED BY A DAIRY RUMINANT - A method involves at least measuring the weight quantity of at least one fatty acid (AG), derived from de novo synthesis, in a sample of milk from said ruminant and evaluating said quantity of methane according to the following formula: CH4=a*(de novo AG)+y*(BH AG)+z.08-22-2013
20100004872METHOD FOR QUANTITATIVE MEASUREMENT OF CARDIAC BIOCHEMICAL MARKERS - This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different cardiac biochemical markers in a serum sample, which can be used for the early diagnosis of cardiovascular diseases and myocardial infarction. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies used for the detection of representative cardiac biochemical markers in a serum sample.01-07-2010
20110144918BIOLOGICAL INFORMATION DISPLAY DEVICE, BIOLOGICAL INFORMATION DISPLAY SYSTEM, STATISTICAL PROCESSING METHOD, AND RECORDING MEDIUM RECORDING THEREON STATISTICAL PROCESSING PROGRAM - A biological information display device displays measurement results for a plurality of times, for example, as result information on first measurement results for a plurality of times (S06-16-2011
20090177408METHODS AND SYSTEMS FOR HIGH CONFIDENCE UTILIZATION OF DATASETS - Methods and systems for high-confidence utilization of datasets are disclosed. In one embodiment, the method includes selecting a metric for determining substantially optimal combination of true positives and false positives in a data set, applying an optimization technique, and obtaining, from the results of the optimization technique, a value for at least one optimization parameter, the value for at least one optimization parameter resulting in substantially optimal combination of true positives and false positives. A number of true positives and a number of false positives are a function of the one or more optimization parameters.07-09-2009
20080306694Methods for Detecting Peaks in a Nucleic Acid Data Trace - The present invention relates to methods and apparatus for detecting peaks in a sample nucleic acid data trace derived from a sample polynucleotide by (a) receiving a sequence signature of a reference polynucleotide, wherein the sequence signature comprises a profile of peak height at one or more peak position of a nucleic acid sequence data trace of one or more of reference polynucleotides; (b) receiving a sample nucleic acid sequence data trace of a sample polynucleotide corresponding to the reference polynucleotide, wherein the sample nucleic acid sequence data trace comprises a value of peak height at one or more peak position corresponding to the peak positions of the sequence signature; and (c) detecting peaks in the sample nucleic acid data trace having a peak height that correlates with the profile of peak height of the sequence signature at a corresponding peak position.12-11-2008
20090055101METHOD FOR ESTIMATING MOLECULE CONCENTRATIONS IN A SAMPLING AND EQUIPMENT THEREFOR - This method for estimating molecule concentrations in a measurement line that can include a liquid phase chromatographic column or a mass spectrometry is based on statistical calculations to transform, in an analytical model of the received signal, the factors (measured results or measurement parameters) into probability distributions from a priori estimations. The final values of the results are inferred from a parameter, such as the average, of these probability distributions. The method is excellent in properly assessing measurement peaks in signals with noise or superimposed with other peaks, which is not carried out properly by conventionally peak analysis or spectral analysis methods.02-26-2009
20090326831Concatenated Scalograms - Embodiments may include systems and methods capable of processing an original signal by selecting and mirroring portions of the signal to create new signals. Any suitable number of new signals may be created from the original signal and scalograms may be derived at least in part from the new signals. Regions of the scalograms may be selected based on a characteristic of the original signal. The selected regions may be concatenated, and a sum along amplitudes across time may be applied to the concatenated regions. Desired information, such as respiration information within the original signal, may be determined from the sum along amplitudes across time.12-31-2009
20090326829Method and System for Monitoring Consumable Item Usage and Providing Replenishment Thereof - Method and system for providing a subscription based replenishment transaction of consumable items such as glucose test strips, lancets, and medication, such as insulin, including a data network, a user terminal operatively coupled to the data network, the user terminal configured to receive and transmit data over the data network, and a server terminal operatively coupled to the data network, the server terminal configured to receive from the user terminal a request for establishing an account associated with a consumable item, receive from the user terminal one or more predetermined parameters associated with the account, and generate the account based on the one or more predetermined parameters, where the one or more predetermined parameters include a user specified consumable replenishment level received from the user terminal is disclosed.12-31-2009
20080319678Mass Tagging for Quantitative Analysis of Biomolecules using 13C Labeled Phenylisocyanate - The present invention provides novel compositions and methods for mass-tagging peptides and proteins which are useful for identifying and quantifying mixtures of peptides and proteins.12-25-2008
20090012713Methods of Assessing Cognitive Dysfunction - This invention relates to methods and means for assessing cognitive dysfunction, in particular impulsivity associated cognitive dysfunction, which may for example include Attention Deficit Hyperactivity Disorder (ADHD), substance abuse, and non-toxic addictive/compulsive behaviour. A method may comprise displaying a population of elements to the individual and allowing the sequential selection of elements within the population by the individual. The selection of an element reveals to the individual a characteristic of the selected element which is one of a number of possible characteristics of elements in said population. The sequential selection ends when the individual chooses which of the possible characteristics is possessed by the most elements in the population. The number of elements selected by the individual in making this choice is then correlated to the likelihood that the individual has impulsivity associated cognitive dysfunction.01-08-2009
20110224913METHODS AND SYSTEMS FOR PREDICTING PROTEINS THAT CAN BE SECRETED INTO BODILY FLUIDS - The present invention is directed to methods and systems for predicting protein secretion into bodily fluids. In an embodiment, a method uses a feature set comprising secretory properties of collected proteins to train a classifier, based on the feature set, to recognize protein features corresponding to proteins that are likely to be secreted into a biological fluid. Another method determines, using a trained classifier and identified features of a received protein sequence, the probability of the protein sequence being secreted into a biological fluid. In an embodiment, a system predicts the secretion of proteins into a biological fluid. The system comprises components configured to construct a protein feature set comprising properties of collected proteins, train a classifier to predict features of a protein that is likely to be secreted into the biological fluid, receive a protein sequence, and identify the received protein sequence as a secretory protein.09-15-2011
20110224912Physiological Monitor System for Determining Medication Delivery and Outcome - A method is described for the determination of the taking of a medication utilizing at least one physiological parameter monitoring platform. In addition, the method also may enable the determination of physiological effects or events resultant from the taking of a medication (or lack thereof) through the use of one or more physiological monitoring platforms.09-15-2011
20110224910METHODS OF NORMALIZING MEASURED DRUG CONCENTRATIONS AND TESTING FOR NON-COMPLIANCE WITH A DRUG TREATMENT REGIMEN - Methods for monitoring subject compliance with a prescribed treatment regimen are disclosed. In one embodiment, the method comprises measuring a drug level in fluid of a subject and normalizing said measured drug level as a function of one or more parameters associated with the subject. The normalized drug level is compared to a reference value and associated confidence intervals or to a concentration range. The reference value and associated confidence intervals and/or the concentration range may be normalized based on one or more parameters associated with subjects in a reference population.09-15-2011
20110224909SIGNAL PROCESSING TECHNIQUE FOR AN IMPEDANCE BIOSENSOR - A method for determining impedance includes receiving a time varying voltage signal from a biosensor and receiving a time varying current signal from the biosensor. The time varying voltage signal and the time varying current signal are transformed to a domain that represents complex impedance values. Parameters based upon the impedance values using at least one of an explicit decimation process and an implicit decimation process.09-15-2011
20110224908Gene signature for diagnosis and prognosis of breast cancer and ovarian cancer - A first embodiment is a breast cancer prognosticator comprising a detection mechanism consisting a 15-gene signature. In addition there are embodiments comprised of 23-gene signatures and 28-gene signatures. The 28-gene signature may also be used for the prognosis of ovarian cancer. A second embodiment is a method to determine metastatic potential, relapse potential, or both in breast cancer patients comprising collecting a sample from an individual, removing marker-derived polynucleotide from said sample, using a detection mechanism to search for positive matches of said polynucleotides and either the 15, 23, or 28-gene signatures, and developing a quantitative expression profile. Utilizing risk analysis the individual can be placed into one of two or more groups predicting risk and/or clincopathogic variables. Another embodiment is a method to determine relapse free potential in breast cancer patients comprising collecting a sample from an individual, removing marker-derived polynucleotide from said sample, using a detection mechanism to search for positive matches of said polynucleotides and a 24-gene signature, and developing a quantitative expression profile.09-15-2011
20090024329Methods and systems relating to epigenetic information - The present application relates, in general, to a system or method for detection or treatment. In some aspects, a system includes at least one computer program for use with at least one computer system and wherein the computer program includes a plurality of instructions including, but not limited to, one or more instructions for determining at least one correlation between at least one aspect of epigenetic information regarding at least one individual and information regarding at least one clinical outcome following receipt by the at least one individual of at least one medical therapy.01-22-2009
20090024330METHODS AND SYSTEMS RELATING TO EPIGENETIC PHENOTYPES - In one aspect, a system includes, but is not limited to, at least one computer program for use with at least one computer system and wherein the computer program includes a plurality of instructions, including but not limited to, one or more instructions for determining at least one correlation between at least one epigenetic-influencing event and at least one aspect of epigenetic phenotype information regarding at least one individual.01-22-2009
20090082971COMBINED IMAGE PROCESSING COMPUTER FOR MEDICAL DIAGNOSTICS IN THE FIELDS OF RADIOGRAPHY AND FLUOROSCOPY - A combination radiography and fluoroscopy system includes in one embodiment a radiography radiation generator and radiography radiation receiver, a fluoroscopy radiation generator and fluoroscopy radiation receiver, and a single computer system connected to receive signals from the radiography radiation receiver and fluoroscopy radiation receiver. The single computer system includes signal processing paths for the radiography signal and for the fluoroscopy signal wherein some processes or modules are common between the paths and some are path specific. The path specific processes are preferably connected in parallel. Common controls and a common interface are provided to the monitor connected to the computer system. An alternative uses a single radiation receiver for both radiography and fluoroscopy, along with the single computer system Another alternative provides for separate computers for signal processing of the radiography and fluoroscopy signals, the two computers running substantially identical signal processing programs.03-26-2009
20090198450Integrated Biosensor and Simulation System for Diagnosis and Therapy - BioMEMS/NEMS appliance biologically monitors an individual, using biosensors to detect cellular components. Data is simulated or analyzed using systems-biology software, which provides diagnostic or therapeutic guidance.08-06-2009
20090198449Dual-Slot Biological Test Meter Test Procedure - A dual-slot biological test meter test procedure includes the steps of a) inserting a code card into a first test slot of a dual-slot biological test meter, b) inserting a test strip into a second test slot of the dual-slot biological test meter to initiate the dual-slot biological test meter; c) inputting predetermined parameters into the dual-slot biological test meter, d) judging if the result is over the threshold or not after application of the blood sample to the reaction zone of the inserted test strip, and then entering a first stage to electrically connect the two electrodes of the inserted test strip if the result is over the threshold, and then entering a second stage to output a voltage to the electrodes of the inserted test strip for a predetermined length of time set by the code card, e) entering a third stage to read the current value subject to the setting of the code card when the predetermined length of time is up, then f) calculating the test result through a computing method set by the code card subject to the current value obtained; and then g) showing the test result on a display.08-06-2009
20110144919BIOMARKER NORMALIZATION - A fluid sample is measured with a tear film measuring system that includes a processing device that receives a sample chip comprising a sample region configured to contain an aliquot volume of sample fluid, the processing device configured to perform analyses of osmolarity and of one or more biomarkers within the sample fluid, wherein the analysis of biomarkers includes normalization of biomarker concentration values.06-16-2011
20110144915FILL SUFFICIENCY METHOD AND SYSTEM - Described and illustrated herein are one exemplary method and a measurement system having a meter and a test strip. The test strip has a first working electrode, reference electrode and second working electrode. In this method, acceptable fill data from known first current and known second current are used to predict an estimated second current at proximate the second time period (for a given batch of test strips) during the test sequence. The estimated second current at proximate the second time interval is then compared with a measured actual second current at proximate the second time interval during an actual test to determine if the measured actual second current is substantially equal to or within an acceptable percent deviation from the estimated second current so as to determine sufficient volume of a physiological fluid sample in the test strip.06-16-2011
20090248317BIOLOGICAL SAMPLE ANALYZER AND COMPUTER PROGRAM PRODUCT - The present invention is to present a biological sample analyzer, comprising: a characteristic information obtainer for obtaining characteristic information representing a characteristic of a component contained in a biological sample of a patient; a processor; and a memory storing software instructions adapted to enable the processor to perform operations comprising: (a) analyzing the characteristic information based on a first condition for analyzing a biological sample of a patient who does not have a predetermined attribution; and (b) analyzing the characteristic information based on a second condition for analyzing a biological sample of a patient who has the predetermined attribution.10-01-2009
20110144920METHOD, SYSTEM AND DEVICE FOR ENHANCING FLOW FIELD DATA - A method, system and device are described for generating high-resolution flow-field data from sparse measurement data by interpolating from a reference database of pre-computed, highly-resolved fluid dynamic simulation results, to generate a highly-resolved set of flow field data which correspond to the sparse measurements. In one embodiment, the method, system and device use Principal Component Analysis techniques to interpolate the multidimensional fluid flow data. Applications of the invention are, amongst others, in the field of biomedical diagnosis involving fluid dynamic modeling of biological fluid systems such as blood flow in an artery.06-16-2011
20090055100METHOD FOR IDENTIFYING AND/OR CHARACTERIZING A (POLY)PEPTIDE - The present invention relates to a method for identifying and/or characterizing a (poly)peptide comprising: (a) analyzing a peptide map of said (poly)peptide, comprising at least 1 peptide, and its peptide primary structure fingerprint by mass spectrometry; and (b) comparing data obtained in step (a) with a reference (poly)peptide database, said database comprising mass spectrometric data of peptide maps, comprising at least 1 peptide, and of its peptide primary structure fingerprint, of a (poly)peptide or of a variety of (poly)peptides.02-26-2009
20090082974Methods and systems for treating disease - Methods and systems described herein are applicable to the identification of pathogens, pathogenic variants and applicable treatments or remedies. In some embodiments, the pathogen or pathogens bears a causal relationship to a disease state.03-26-2009
20090082973ANALYSIS SYSTEM FOR DETERMINING AN ANALYTE IN A BODY FLUID - An analysis system for determining an analyte of a body fluid comprises a test element and an analysis instrument having a measurement and evaluation unit. The test element has a sample application zone and two analysis zones and a reagent system, whose reaction with the analyte results in a detectable change characteristic for the desired analytical result. The measurement and evaluation unit comprises two analog measuring units, in each of which an analog measurement signal corresponding to one of the analysis zones is generated, two analog-digital converters for digitizing the analog measurement signal, a comparator unit for comparing control data values based on the digitized measurement signals, and a final processing unit, in which, if the determined deviation between the control data values of the digitized measurement signals is less than a predefined value, at least one of the control data values is allowed to pass for further processing into the desired analytical result.03-26-2009
20090076731METHOD AND DEVICE AND PREDICTING PHYSIOLOGICAL VALUES - The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.03-19-2009
20090076732SYSTEMS AND METHODS FOR THE ANALYSIS OF MECHANICAL PROPERTIES OF MATERIALS - The various embodiments of the present invention relate generally to the analysis of the mechanical properties of materials. More particularly, the various embodiments of the present invention relates to systems and methods of deriving the static and dynamic mechanical properties of deformative materials, for example, but not limited to, biological surfaces. The systems and methods of the present invention can be used to derive and evaluate the mechanical properties of many biological surfaces and subsurfaces, including but not limited to the skin.03-19-2009
20110231107TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.09-22-2011
20110231106STATUS DETERMINATION - The present invention provides a method of determining the status of a subject. In particular, this is achieved by obtaining subject data including respective values for each of a number of parameters, the parameter values being indicative of the current biological status of the subject. The subject data is compared to predetermined data which includes values for at least some of the parameters and an indication of the condition. The status of the subject, and in particular, the presence and/or absence of the one or more conditions, can then be determined in accordance with the results of the comparison.09-22-2011
20090204340Method Of Calibrating An Analyte-Measurement Device, And Associated Methods, Devices And Systems - The invention relates to a method for calibrating an analyte-measurement device that is used to evaluate a concentration of analyte in bodily fluid at or from a measurement site in a body. The method involves measuring a concentration, or calibration concentration, of an analyte in blood from an “off-finger” calibration site, and calibrating the analyte-measurement device based on that calibration concentration. The invention also relates to a device, system, or kit for measuring a concentration of an analyte in a body, which employs a calibration device for adjusting analyte concentration measured in bodily fluid based on an analyte concentration measured in blood from an “off-finger” calibration site.08-13-2009
20090204338Method of deriving a quantitative measure of the instability of calcific deposits of a blood vessel - A computer-implemented method of processing an image of at least part of a blood vessel to derive a measure indicative of the instability of calcific deposits in the blood vessel, said blood vessel containing at least one calcific deposit, comprises locating and annotating one or more calcific deposits. Using information derived from the annotation of said calcific deposits, the method further comprises calculating a measure reflecting either one or both of a) the aggregate of the deviations from roundness of individual calcific deposits, and b) up to at least a threshold value, the extent to which the separate calcific deposits are spaced from one another.08-13-2009
20110231103METHODS FOR DETERMINING MOLECULAR PHARMACOLOGY USING LABEL-FREE INTEGRATIVE PHARMACOLOGY - Disclosed are methods and machines to perform cluster analysis on label free biosensor data.09-22-2011
20110231101BODY MOVEMENT ANALYSIS METHOD AND APPARATUS - A method and apparatus is disclosed for calculating a mobility performance index of a patient. The method includes the steps of: measuring an activity signal; identifying an activity type by segmenting said activity signal; calculating a measure for a selected said identified activity type; and calculating a mobility performance index from said measure.09-22-2011
20090099788PROTEIN STRUCTURE ANALYSIS - Techniques for analyzing one or more protein structures. In one aspect of the invention, the technique comprises the following steps. A normalized second-order hydrophobic moment is determined for a protein structure. The normalized second-order hydrophobic moment is then used for analysis of the protein structure. A scoring function in accordance with the normalized second-order hydrophobic moment for the protein structure may be determined. A score for the protein structure may then be generated using the scoring function. The scoring function may represent an integral of the normalized second-order hydrophobic moment. The scores may be generated for a plurality of protein structures. The scores generated for the plurality of protein structures may then be compared.04-16-2009
20090093966Hybridization data processing method using probe array - A data processing method of reducing signals to numerical values and processing the numerical values are provided. The signals are obtained by using a probe array where probes of a plurality of kinds are immobilized on a solid phase as so many spots such that a plurality of spots of probes of one kind are arranged on the solid phase and causing the array to react with a target substance. The method comprises (04-09-2009
20090326828Optimizing Selection of SRM Transitions for Analysis of Biomolecules by Tandem Mass Spectrometry - Methods for selecting a set of SRM transitions for a peptide of interest include selecting a first transition based on sensitivity criteria and selecting at least a second transition based on selectivity criteria. A determination of the uniqueness of the first transition combined with the at least a second transition is made. When the combination of the first transition and the at least a second transition is determined to be unique to the peptide of interest, a sample containing the peptide of interest is subjected to a SRM workflow by monitoring the first transition and the second transition. Also described is an apparatus for carrying out the methods.12-31-2009
20120078529DETERMINING THE SEVERITY OF 5-FLUOROURACIL OVERDOSE - A severity score for 5-fluorouracil (5FU) toxicity is calculated by taking the square root of the sum of: (a) the square of the logarithm of the dose of 5-fluorouracil administered to the patient; and (b) the square of the logarithm of the administration rate of the 5-fluorouracil to the patient.03-29-2012
20120078527KIT AND METHOD FOR PREDICTING SENSITIVITY OF GASTRIC CANCER PATIENT TO ANTI-CANCER AGENT - A kit and method for predicting the sensitivity of gastric cancer patient to an anti-cancer agent are disclosed.03-29-2012
20120078526APPARATUS, SYSTEM AND METHODS FOR DETERMINING DRUG ATTRIBUTES USING DISEASE SIGNATURE HOLISTIC ANALYSIS AND PHARMACOLOGICAL DATA - Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example of the inventive apparatus includes a standardizer to at least one of standardize and normalize data related to drug performance for a known disease signature; and a deviation analyzer to analyze said data based on at least one of a plurality of different efficacy metrics, wherein a quantified variation between a first data set of results corresponding to an identified target drug and a second data set of results corresponding to a control, wherein said first data set of results is provided for comparison with the second data set of results and the deviation therebetween is compared to the at least one efficacy metric associated with the disease signature.03-29-2012
20120078525APPARATUS, SYSTEM AND METHODS FOR SELECTING DRUG CANDIDATES USING DISEASE SIGNATURE HOLISTIC ANALYSIS AND PHARMACOLOGICAL DATA - Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example method includes providing a first set of data corresponding to a drug of interest: providing a disease signature; providing a reference set of drug interaction data associated with the disease signature, comparing the first set of data to the reference set using a holistic analysis, and reporting the results of the comparison. An example of the apparatus includes, a standardizer to at least one of standardize and normalize drug interaction data related to a pre-selected disease signature: a deviation analyzer to compare the drug interaction data to data corresponding to a drug under review using a holistic analysis, and a reporter for reporting the output of the deviation analyzer.03-29-2012
20120078522SYSTEMS AND METHODS FOR HOLISTIC ANALYSIS AND VISUALIZATION OF PHARMACOLOGICAL DATA - Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example method includes accessing data related to drug development; pre-processing the data to prepare the data for measurement and analysis; and analyzing the data based on at least one of a plurality of different metrics. Each metric corresponds to a quantified variation between a first data set of results corresponding to a category in the drug development process. The first data set of results is provided for comparison with a second data set of results corresponding to at least one other category in the drug development process. At least some of the plurality of metrics are aggregated to generate a visual representation representing an integrated comparative visualization for the identified category.03-29-2012
20120078521APPARATUS, SYSTEM AND METHODS FOR ASSESSING DRUG EFFICACY USING HOLISTIC ANALYSIS AND VISUALIZATION OF PHARMACOLOGICAL DATA - Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example method includes a computer-implemented method for assessing drug efficacy, comprising: accessing a first data set related to the performance of a target drug for a given indication; accessing a second data set related to a control for the indication; comparing the data for the target drug and the data for the control on at least one of a plurality of different metrics using a holistic analysis, wherein the at least one metric corresponds to an outcome associated with the indication and generating a corresponding report. An example apparatus/system includes a holistic analysis and viewing system to support the assessment of drug efficacy, said system comprising: a standardizer to at least one of standardize and normalize data related to drug development; a deviation analyzer to analyze said data based on at least one of a plurality of different efficacy metrics, wherein a quantified variation between a first data set of results corresponding to an identified target drug and a second data set of results corresponding to a control, wherein said first data set of results is provided for comparison with the second data set of results and the deviation therebetween is compared to the at least one efficacy metric.03-29-2012
20090210162METHOD AND APPARATUS FOR ESTIMATING A PAO2 VALUE FOR A PATIENT SUBJECT TO EXTRACORPOREAL CIRCULATION - The invention relates to a method and an apparatus for estimating a P08-20-2009
20080262746METHOD AND DEVICE FOR PREDICTING PHYSIOLOGICAL VALUES - The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.10-23-2008
20080262742COMPUTATIONAL METHOD AND APPARATUS FOR PREDICTING POLYPEPTIDE AGGREGATION OR SOLUBILITY - A prediction method for predicting the effect of an amino acid modification on the rate of aggregation (solubility) of a reference polypeptide comprising: calculating the difference in hydrophobicity (ΔHydr) between the reference polypeptide and a modified polypeptide, calculating the difference in β-sheet propensity (ΔΔG10-23-2008
20080262744Systems and Methods for Tissue Engineering Tubular Biological Structures - The present invention relates to systems and methods for tissue engineering. In particular, the invention is directed toward systems and methods for conditioning tubular biological structures. For example, an aspect of the present invention comprises systems and methods for uncoupling local mechanical parameters (e.g., circumferential stress, shear stress, and axial stress) from global mechanical parameters (e.g. lumen pressure, flow rate of perfusate, and longitudinal stretch of the construct) to control of local mechanical parameters for conditioning a tubular biological construct.10-23-2008
20080262743Methods for remote characterization of an odor - Provided are compositions and systems useful in remote monitoring of chemical hazards, air quality, and medical conditions, for example, robotic systems to search for and detect explosives, mines, and hazardous chemicals. In addition, the methods, systems and compositions of the invention provide the ability to mine data from a database containing a plurality of chemical fingerprints.10-23-2008
20080262741METHOD AND APPARATUS FOR SCREENING CHEMICAL COMPOUNDS - Methods and apparatus for screening large numbers of chemical compounds and performing a wide variety of fluorescent assays, including live cell assays. The methods utilize a laser linescan confocal microscope with high speed, high resolution and multi-wavelength capabilities and real time data-processing. Imaging may be done at video-rates and with use of ultraviolet illumination.10-23-2008
20080262740PERMITTIVITY-BASED MATERIAL SENSOR - A system for sensing a presence and/or a concentration of a target substance in a fluid has a sensor and a processor coupled to the sensor. The sensor has a test probe having at least first and second test electrodes, wherein at least the first test electrode is functionalized to create a permittivity change in the area between the first and second test electrodes in the presence of the target substance. The sensor also has a reference probe having at least first and second reference electrodes. The processor is configured to determine at least one permittivity-based metric for the test probe; determine the at least one permittivity-based metric for the reference probe; and determine the presence and/or the concentration of the target substance based on the at least one permittivity-based metric for the test probe and the at least one permittivity-based metric for the reference probe. Related methods are disclosed.10-23-2008
20080262739Submersible Portable In-situ Automated Water Quality Biomonitoring Apparatus and Method - A submersible biomonitoring system for monitoring water quality in situ includes a submersible chamber constructed of a di-electric material and sized to allow suitable signals from one or more aquatic organisms to be received by eliminating cross-talk between cells while allowing ambient conditions to be maintained inside the chamber. The aquatic organism exhibits ventilatory behavior and body movement sensitive to water quality which manifest as electrical signals picked up by electrodes and communicated to a pre-amplifier that conditions the signals for communication to a land-based amplifier and/or controller that is used to interpret the signals to determine when the water to which the organism is exposed has caused physiological stress to the organism.10-23-2008
20090204341SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR - Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.08-13-2009
20080288176Development of Prodrugs Possessing a Nitric Oxide Donor Diazen-1-Ium-1,2-Diolate Noiety Using in Vitro/in Silico Predictions - The present invention provides a method of using a physiologically-based pharmacokinetic model to select a prodrug molecule (NO—X) comprising a therapeutic agent X (e.g. nonsteroidal anti-inflammatory drug, (NSAID)) and an appropriate nitric oxide donor NO. The NSAID can be a non-selective or selective cyclooxygenase inhibitor or other biocompatible compound comprising a carboxyl group. The pharmacokinetic model uses in vitro and/or in silico data to estimate an optimal set of parameters that can predict whether a particular NO—X candidate is capable of producing desirable therapeutic effects, e.g. enhanced anti-inflammatory activity, reduced intestinal, cardiac and renal toxicity. Accordingly, the present invention can greatly enhance proper selection of an appropriate candidate for drug development, thereby minimizing development time and conserving costs.11-20-2008
20110144914BIOMARKER ASSAY FOR DIAGNOSIS AND CLASSIFICATION OF CARDIOVASCULAR DISEASE - The disclosed methods, assays and kits identify biomarkers, particularly miRNA and/or protein biomarkers, for assessing the cardiovascular health of a human. In certain embodiments, methods, assays and kits, circulating miRNA and/or protein biomarkers are identified for assessing the cardiovascular health of a human.06-16-2011
20110144916COMPUTER METHOD AND APPARATUS FOR CLASSIFYING OBJECTS - A computer classification method and apparatus employs statistical analysis of known objects in the class of interest. For each known object in the class, a respective vector of q bits is formed. Each bit indicates presence or absence of an activity or physical property in the object. The probability that a bit is equal to 1 in the class is then applied to vector representations of test objects and determines probability of the test object belonging, to the class.06-16-2011
20110144917SYSTEM AND METHOD FOR IDENTIFICATION OF SYNERGISTIC INTERACTIONS FROM CONTINUOUS DATA - Systems and methods for selecting factors from a continuous data set of measurements are provided. The measurements include values of factors and/or outcomes. Two or more factors that are jointly associated with one or more outcomes from the data set are identified. Each of the two or more factors are analyzed to determine at least one cooperative interaction among the factors with respect to an outcome. The two or more factors can be a module of factors serving as a single factor participating in a cooperative interaction with another factor or module of factors.06-16-2011
20090204334LUNG CANCER BIOMARKERS - Disclosed are protein biomarkers and their use in diagnosing lung cancer or to make a negative diagnosis in patients. Also disclosed are kits for the diagnosis of lung cancer that detect the protein biomarkers of the invention, as well as methods using a plurality of classifiers to make a probable diagnosis of lung cancer. In certain aspects of the invention, the methods include use of a decision tree analysis. Various computer readable media and their use according to the invention are also disclosed.08-13-2009
20110231104SYSTEM AND METHOD FOR TARGETING RELEVANT RESEARCH ACTIVITY IN RESPONSE TO ANGIOGENIC REGULATOR ANALYSES - A system and method for targeting relevant research activity for clinical application in response to angiogenic regulator analyses. An angiogenic analysis is performed on a patient blood sample in order to detect the level of each of at least ten angiogenic regulators. The levels of the tested regulators are used as indexes to identify relevant peer-reviewed research publications from among a large database of articles. The most relevant peer-reviewed literature reporting research and studies that have been conducted to identify, moderate, and define the mechanisms unique to individual and combinations of angiogenic regulators for various disease states are then provided to the patient and/or to the patient's physician, optionally in conjunction with a summarization of the treatment recommendations gleaned from the provided literature. The customized information delivery provides the patient and physician a range of published peer-reviewed therapeutic options and published research studies for moderating the out of range regulators to within normal range or other diagnostic significant range.09-22-2011
20090254284System for providing animal test information and method of providing animal test information - A system for providing animal test information is disclosed that comprises: test devices; and a central device communicably connected to the test devices, wherein each of the terminal test devices comprises: an input receiving section for receiving input of attribution information of a sample; a measurement section for measuring the sample and acquiring a measurement result; an information transmitting section for transmitting a data set of the attribution information and the measurement result to the central device, wherein the central device comprises: an information receiving section for receiving the data set; a data storage for storing a plurality of the data set; a standard value calculation section for calculating a standard value to be used for determining a treatment of an animal, based on a plurality of the measurement result included in a plurality of the data set which have common attribution information.10-08-2009
20090222215Integrated Biosensor and Simulation System for Diagnosis and Therapy - BioMEMS/NEMS appliance biologically monitors an individual, using biosensors to detect cellular components. Data is simulated or analyzed using systems-biology software, which provides diagnostic or therapeutic guidance.09-03-2009
20090222214METHOD AND APPARATUS FOR MEASURING NON-NUTRITIVE SUCK PATTERN STABILITY - Method and apparatus are provided for generating an index associated with non-nutritive suck pattern stability. A method includes measuring a plurality of non-nutritive suck (NNS) pressure samples, generating a plurality of correlation values using the NNS pressure samples, and generating a measure of non-nutritive suck pattern stability using the plurality of correlation values.09-03-2009
20090248318SAMPLE ANALYZER, SAMPLE ANALYZING METHOD AND COMPUTER PROGRAM PRODUCT - The present invention is to present a sample analyzer, comprising: a sample preparing section for preparing a measurement sample from a sample and a reagent; a detector for detecting a predetermined component contained in one measurement sample prepared by the sample preparing section; and a data processing section being configured to perform operations comprising: (a) generating a plurality of analysis data for analyzing the predetermined component based on a detection result by the detector; (b) selecting one analysis data from the plurality of analysis data; (c) analyzing the predetermined component based on at least the one analysis data selected in the operation (b); and (d) outputting an analysis result obtained in the operation (c).10-01-2009
20090248314Network-based system and method for diagnostic pathology - An optimized network-based system and method for providing reagents or reagent-like matter for the differential diagnosis of medical conditions using a hosted software program coupled with a comprehensive medical reference database. Suspected diagnoses of medical conditions are entered into the system by a user. Using meta-analysis, the system generates a list of potential reagents and numerical measures of each reagent's behavior for each differential for use in further testing. The results of the testing are compared by the user against numerical measures of each reagent's behavior and corresponding stored digital images in the network-based system. The user then selects among those diagnoses in the system whose images and corresponding numerical measures of each reagent's behavior are most comparable with the results of the testing. The system then generates a diagnosis, diagnoses, or inconclusive results in order to reach an ultimate diagnosis.10-01-2009
20120197539METHODS FOR DIAGNOSIS, TREATMENT AND MONITORING OF PATIENT HEALTH USING METABOLOMICS - A method for assessing patient health is provided using metabolomics. The method comprises providing a bodily fluid or tissue sample from a subject, collecting a metabolic profile from the bodily fluid or tissue sample and comparing the metabolic profile to a reference profile, wherein the preferred bodily fluid is urine. Reference profiles are also provided.08-02-2012
20090204333METHODS FOR USING CO-REGULATED GENESETS TO ENHANCE DETECTION AND CLASSIFICATION OF GENE EXPRESSION PATTERNS - The present invention provides methods for enhanced detection of biological response patterns. In one embodiment of the invention, genes are grouped into basis genesets according to the co-regulation of their expression. Expression of individual genes within a geneset is indicated with a single gene expression value for the geneset by a projection process. The expression values of genesets, rather than the expression of individual genes, are then used as the basis for comparison and detection of biological response with greatly enhanced sensitivity. In another embodiment of the invention, biological responses are grouped according to the similarity of their biological profile.08-13-2009
20120197535Methods for identifying bacteria - The present invention provides methods for identifying bacteria by analysis of lipid A and/or lipoteichoic acid structure and/or mass spectrometry ionization patterns.08-02-2012
20090259407APPARATUS AND METHODS FOR NON-INVASIVE MEASUREMENT OF A SUBSTANCE WITHIN A BODY - Embodiments of the present system and methods measure a concentration of a substance, such as glucose, in a body. The present embodiments measure a first amount of infrared (IR) radiation absorbed or emitted from the body in a first wavelength band, and a second amount of IR radiation absorbed or emitted from the body in a second wavelength band. The present embodiments also measure a temperature at a surface of the body and an ambient temperature. A normalized ratio parameter is calculated from the four measurements, and the concentration of the substance in the body is calculated by correlating the normalized ratio parameter with the body surface temperature and the ambient temperature using an empirically derived lookup table. Also disclosed are methods for creating the empirically derived lookup table.10-15-2009
20090192724TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.07-30-2009
20090240439Predicting responses to drugs or drug cadidates - Patients can be segregated into groups expected to have differential responses to drug treatment based on test results. Patient sub-populations expected to benefit from a particular treatment can thus be identified and directed to that treatment. Similarly, sub-populations expected to suffer a greater risk of side effects from a particular treatment can be identified and steered to other, safer treatments. A patient under treatment can be monitored for safety.09-24-2009
20100153017Methods and Workflows for Selecting Genetic Markers Utilizing Software Tool - A visual tool facilitates selecting SNPs for genotyping experiments comprises a first memory containing a datastore of pre-calculated linkage disequilibrium map information; a second memory containing a datastore of haplotype block information; and a third memory containing at least one set of tagging SNPs. A graphical user interface provides visualization of SNPs, integrated with a physical genome map. A stepwise selection tool associated with the graphical user interface facilitates selection of tagging SNPs by selectively using the information in at least one of the first, second and third memories.06-17-2010
20100274497Closed Loop Blood Glucose Control Algorithm Analysis - Methods and devices to generate a tool for testing, simulating and/or modifying a closed loop control algorithm are provided. Embodiments include receiving glucose data for a predetermined time period, determining a variation in the glucose level based on the received glucose data, filtering a received glucose data based on the determined variation, substituting a negative change in the glucose data value with a predetermined value to generate a sequence of modified glucose values, and integrating the sequence of modified glucose values to determine an uncontrolled blood glucose excursion condition.10-28-2010
20100274496DEVICE FOR MEASUREMENT OF TRANSPORT SYSTEMS - The invention relates to a device (10-28-2010
20100179766Method for Identifying Peptides Using Tandem Mass Spectra by Dynamically Determining the Number of Peptide Reconstructions Required - A method for identifying peptides using tandem mass spectrometry takes the spectrum for a peptide to be analyzed and uses a scoring function to score a match between the spectrum and each candidate peptide in a peptide database. The scoring function has a value corresponding to a number of fragment peaks in the spectrum that match fragment peaks in a spectrum of the candidate peptide. Using the match scores, a generating function of the spectrum is computed to determine the number of peptide reconstructions at each value of the scoring function. The generating function is then used to determine the number of candidate peptides for each match score and the probability of a peptide having a given match score to the spectrum. A spectral probability can be determined by calculating the total probability of all peptides with scores equal to or larger than the given match score.07-15-2010
20100161236Pattern Recognition and Filtering in a Therapy Management System - A method of diabetes analysis includes receiving a plurality of glucose level readings for a user. A common event occurrence in at least two of the glucose level readings is determined. The at least two glucose level readings from the common event occurrence onwards in time for a time period is analyzed. A glucose level pattern formed by the at least two glucose level readings having a similar shape is determined. At least one anomalous glucose level reading having the similar shape and not conforming to the glucose level pattern is analyzed. The at least one anomalous glucose level reading is adapted to the pattern to form an adapted glucose level pattern. An insulin dosage for the time period beginning at the common event occurrence is calculated based on the adapted glucose level pattern.06-24-2010
20090259408Analyzing system, data processing apparatus, and storage medium - An analyzing system, data processing apparatus, and storage medium capable of reducing the complex labor of a technician related to the setting operations of a measuring apparatus. The analysis system is provided with a plurality of measuring apparatuses that perform mutually different measurements of specimens, and a data processing apparatus for analysis processing of the measurement results of the plurality of measuring apparatuses. The data processing apparatus is capable of performing various analysis processes of a plurality of types of measurement results variously obtained from a plurality of measuring apparatuses, and is capable of integratedly managing the measurement results of the plurality of measuring apparatuses and their analysis results.10-15-2009
20100179765Novel Methods and Devices for Evaluating Poisons - Methods and devices useful for evaluating poisons or other chemical entities, and for using such methods to forecast unfavorable drug effects.07-15-2010
20100161238Method and System for Detecting Peptide Peaks in HPLC-MS Signals - The present invention relates to a method, a computer tool and a system for detecting peptide peaks in measurement signals (06-24-2010
20100179763DETECTION OF COUPLED RF CURRENT MRI BODIES - A method for detecting coupled RF current magnetic resonance (MR) objects in a body and determining MR risk is provided. The body is scanned with reverse circularly polarized RF. MR signals generated by coupling of the reverse circularly polarized RF with the RF current MR objects are detected. The detected MR signals are used to determine a risk value.07-15-2010
20100191476BIOLOGICAL SAMPLE PROCESSING APPARATUS THAT SELECTS THE PERSONALITY TYPE OF THE APPARATUS - A biological sample processing apparatus having a central processing unit, a display in communication with the central processing unit and a selector for selecting a personality type of the apparatus, the selector being in communication with the central processing apparatus. The selection of a personality type prompts the central processing unit to cause the display to show a list of preprogrammed protocols for biological sample processing that correspond to the selected personality type.07-29-2010
20100191472Method and Device for Early Signal Attenuation Using Blood Glucose Measurements - Methods and devices to detect analyte in body fluid are provided. Embodiments include receiving one or more analyte sensor data, receiving a reference measurement value associated with an analyte level, determining a sensitivity parameter based on the received one or more analyte sensor data and the reference measurement value, performing a probability analysis based on prior analyte sensor data to determine presence of signal attenuation, and generating an output value based on the probability analysis.07-29-2010
20100191473Apparatus, method, and computer program product for determining gene function and functional groups using chromosomal distribution patterns - A method, apparatus, and computer program product for analyzing gene expressions is presented. An operation is performed for determining a gene expression pattern for a condition, wherein the gene expression pattern comprises a gene expression. Next, a spatial-expression pattern is formed by selecting a chromosomal region having an exon; and associating the gene expression within the gene expression pattern with its corresponding exon. A further operation may be performed, where in the forming of the spatial-expression pattern, a spatial-expression pattern signal is created as a representation of the spatial-expression pattern. The magnitude of the spatial-expression pattern signal at any point is determined by an expression level of the corresponding exon. Spatial patterns may be identified in the signal by means of various signal processing techniques such as Fourier or Wavelet transforms. Also, multiple regions and/or conditions may be tested and their reaction patterns compared to determine related genetic regions.07-29-2010
20120197536METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR CALCULATING DAILY WEIGHTED AVERAGES OF GLUCOSE MEASUREMENTS (OR DERIVED QUANTITIES) WITH TIME-BASED WEIGHTS - A method and system for calculating daily weighted averages of glucose measurements (or derived quantities) with time-based weights are disclosed. The present invention computes an average daily glucose value using the time based weights based on only consecutive glucose measurements in the plurality of glucose measurements with acceptable time intervals that do not exceed a predefined maximum time interval. The invention further relates to a computer program for implementing the method for calculating daily weighted averages of spot monitoring glucose measurements (or derived quantities) with the time-based weights.08-02-2012
20120197537DETERMINATION OF MELTING TEMPERATURES OF DNA - Numerical determinations of the first derivatives of a melt curve data set are made. A model function, such as a Gaussian Mixture Model (GMM) function, with parameters determined using a Levenberg-Marquardt (LM) regression process is used to find an approximation to the first derivative curve. The maximum values of the numerically determined first derivative values are used as initial conditions for parameters of the model function. The determined parameters provide one or more fractional melting temperature values, which can be returned, for example, displayed or otherwise used for further processing.08-02-2012
20100185400COMPUTER PRODUCT, ANALYSIS SUPPORT APPARATUS, AND ANALYSIS SUPPORT METHOD - A non-transitory computer-readable recording medium stores therein an analysis support program causing a computer to execute receiving test result data identifying an analysis subject molecule, and quantity-changing molecules that have changed in quantity due to administration or deficiency of the analysis subject molecule in a test subject; acquiring a first pathway indicating an interaction between the quantity-changing molecules identified by the test result data and a second pathway indicating a molecular interaction with the analysis subject molecule, from a database storing therein for each molecular interaction, a type; determining from among biological phenomena correlated with the interaction between quantity-changing molecules of the first pathway, determines a biological phenomenon other than a biological phenomenon correlated with a molecular interaction of the second pathway to be a novel biological phenomenon caused by administration or deficiency of the analysis subject molecule; and outputting a determination result obtained at the determining.07-22-2010
20130191035METHOD AND SYSTEM FOR DETECTION AND REJECTION OF MOTION/NOISE ARTIFACTS IN PHYSIOLOGICAL MEASUREMENTS - Methods and systems for quantitatively detecting the presence of artifacts in physiological measurement data and for determining usable data among those that have been designated to be corrupted with artifacts are presented.07-25-2013
20080215249Crystallization and structure determination of beta secretase and/or beta secretase-like proteins - The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of human BACE activity.09-04-2008
20080215247Machine and Procedure For Extracorporeal Treatment of Blood - A machine (09-04-2008
20100228493Postural information system and method including direction generation based on collection of subject advisory information - A system includes, but is not limited to: for each one or more instances, determining subject advisory information regarding one or more subjects associated with the instance based at least in part upon postural influencer status information including information involving one or more spatial aspects for each of two or more postural influencers of the one or more subjects, and generating one or more directions based at least in part upon each of the subject advisory information associated with each of the more than one instances. In addition to the foregoing, other related method/system aspects are described in the claims, drawings, and text forming a part of the present disclosure.09-09-2010
20100228496Methods for the Determination of a Copy Number of a Genomic Sequence in a Biological Sample - Methods for the determination of a copy number of a target genomic sequence; either a target gene or genomic sequence of interest, in a biological sample are described. Various methods utilize a model drawn from a probability density function (PDF) for the assignment of a copy number of a target genomic sequence in a biological sample. Additionally, the methods provide for the determination of a confidence value for a copy number assigned to a sample based on attributes of the sample data. Accordingly, the various methods for the determination of a copy number provide the end user with significant information for the evaluation of a copy number of a target genomic sequence; either a gene or genomic sequence of interest.09-09-2010
20100217532SYSTEMS AND METHODS FOR IDENTIFYING STRUCTURALLY OR FUNCTIONALLY SIGNIFICANT AMINO ACID SEQUENCES - Methods and computer readable storage mediums for identifying structurally or functionally significant amino acid sequences encoded by a genome are disclosed. At least one structurally or functionally significant amino acid sequence encoded by a genome may be identified by compiling an observed frequency for each of a plurality of amino acid words encoded by the genome, calculating with a computer an expected frequency for each of the plurality of amino acid words encoded by the genome, and identifying at least one structurally or functionally significant amino acid sequence encoded by the genome based at least in part on the observed and expected frequencies for each of the plurality of amino acid words encoded by the genome.08-26-2010
20120197538AUTOMATED CLINICAL SYSTEM TO FACILITATE SECONDARY REVIEW AND AUTHENTICATION OF CLINICAL LABORATORY RESULT VALUES - A method in a computer system for the review and authentication of clinical laboratory result values is provided. The method includes receiving patient data. The method also includes accessing review criteria. The method further includes comparing the patient data and the review criteria to determine if the patient data should be routed for review. The method further includes routing qualified patient data to a review hierarchy including at least one review queue defined by at least one user.08-02-2012
20120197534BIOMARKER MONITORING DEVICE AND METHOD - A biomarker monitoring method and system in one embodiment includes a communications network, a portable wellness device configured to form a communication link with the communications network, the portable wellness device including a detector configured to detect at least one biomarker in a biologic sample, a first memory, a plurality of program instructions stored in the first memory, and a processing circuit operably connected to the first memory and configured to execute the program instructions to generate wellness data based upon detection of the at least one biomarker in the biologic sample, and a remote user interface operably connected to the communications network and configured to render the wellness data.08-02-2012
20100161239QUANTITATIVE PREDICTION METHOD - The present invention concerns methods and systems for analysis of drug resistance in HIV-1. More specifically, the invention provides methods for predicting drug resistance by correlating genotypic information with phenotypic profiles. The methods allow the identification of primary and secondary resistance-associated mutations for new and existing drugs and for calculating the contribution of mutations and combinations of mutations to resistance and hyper-susceptibility. The invention allows the design, optimization and assessment of the efficiency of a therapeutic regimen based upon the genotype of the disease affecting a patient06-24-2010
20100153020DISULPHIDE BOND CONNECTIVITY IN PROTEIN - A method, computer system, and computer program product for determining N disulphide bond connections in a protein having 2N bonded sulphur atoms. Each sulphur atom is available for forming the N disulphide bond connections through use of an undirected graph having the 2N sulphur atoms as nodes and having an edge connecting each pair of nodes. Each sulphur atom is comprised by a cysteine of the protein. The cysteines are sequenced along a chain in the protein as ordered list of position indexes. A weight W of each edge between cysteine position indexes I06-17-2010
20100228497TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.09-09-2010
20100228489Postural information system and method - A system includes, but is not limited to, a obtaining information module configured for obtaining user advisory information including information regarding one or more users each of two or more devices based at least in part upon physical status information including information regarding one or more spatial aspects of one or more portions of each of the two or more devices, and an output module configured for outputting output information based at least in part upon one or more elements of the user advisory information.09-09-2010
20100228487Postural information system and method - For two or more devices, each device having one or more portions, a method includes, but is not limited to: obtaining physical status information regarding one or more portions for each of the two or more devices, including information regarding one or more spatial aspects of the one or more portions of the device, determining user advisory information regarding the one or more users based upon the physical status information for each of the two or more devices and based upon the user status information regarding the one or more users, and determining user advisory information regarding the one or more users based upon the physical status information for each of the two or more devices and based upon the user status information regarding the one or more users. In addition to the foregoing, other related method/system aspects are described in the claims, drawings, and text forming a part of the present disclosure.09-09-2010
20100228491Cross-Instrument Method and System for Cell Population Discrimination - The present invention provides methods and systems to combine the capabilities of a hematology analyzer with those of a flow cytometer to yield a far more powerful analytical system than either device alone. In one embodiment, a method of analyzing a cell sample includes receiving a first data generated by an analysis of a first aliquot of the sample on a first particle analyzer having a fluorescence measurement device such as a flow cytometer, detecting at least one unresolved cell population in the first data, and accessing a second data stored on a storage device wherein the second data was previously generated by interrogating a second aliquot of the sample using at least one of a cell volume measurement device and a cell conductivity measurement device in a second particle analyzer such as a hematology analyzer. The unresolved cell population in the first data is then resolved using the second data. Corresponding system embodiments are also disclosed.09-09-2010
20100228488Postural information system and method - For two or more devices, each device having one or more portions, a system includes, but is not limited to: one or more obtaining information modules configured to direct obtaining physical status information regarding one or more portions for each of the two or more devices, including information regarding one or more spatial aspects of the one or more portions of the device, one or more determining advisory modules configured to direct determining user advisory information regarding the one or more users based upon the physical status information for each of the two or more devices and based upon the user status information regarding the one or more users., and one or more determining advisory modules configured to direct determining user advisory information regarding the one or more users based upon the physical status information for each of the two or more devices and based upon the user status information regarding the one or more users. In addition to the foregoing, other related method/system aspects are described in the claims, drawings, and text forming a part of the present disclosure.09-09-2010
20110112771Wearable sensor system with gesture recognition for measuring physical performance - A wearable sensor system with gesture recognition for measuring physical performance 05-12-2011
20110112770VEHICLE EVALUATION METHOD AND VEHICLE EVALUATION APPARATUS - The vehicle evaluation method and vehicle evaluation apparatus can appropriately and quantitatively evaluate the sense of lateral oscillation of a vehicle. The method and apparatus measure muscle activity waveforms of a pair of left and right muscles in at least one type of skeletal muscle involved in maintaining a posture of a head of an occupant of the vehicle driven under predetermined driving conditions, calculate an amount of simultaneous activity that expresses characteristics of the muscle activity waveforms and evaluate a sense of lateral oscillation of the vehicle based on the amount of simultaneous activity.05-12-2011
20100217533Identifying a Type of Motion of an Object - A method of identifying a type of motion of an animate or inanimate object is disclosed. The method includes generating an acceleration signature based on the sensed acceleration of the object. The acceleration signature is matched with at least one of a plurality of stored acceleration signatures, wherein each stored acceleration signatures corresponds with type of motion. The type of motion of the object is identified based on the statistical matching or exact matching of the acceleration signature.08-26-2010
20110130968Method for computing ligand - host binding free energies - Methods and systems for computing the binding free energy of a ligand to a host are disclosed. The method entails selecting random poses of a ligand, including translation, rotation, and conformation, and computing the ligand-host interaction energy. The poses are accepted or rejected based on the Metropolis criteria. The entropies of interaction are estimated from the log of the ratio of accepted poses to attempted poses. The free energy of the entire sampling region, and of sub-regions of the binding region, can be accumulated by storing the energies and acceptance ratios for both the entire region and the sub regions. In order to better shape the protein to the ligand, energy minimization of the host atoms in the region of the ligand is carried out in the presence of the lowest free-energy pose of the ligand, optionally preceded by random perturbation of the Cartesian coordinates of the host atoms in the vicinity of the ligand.06-02-2011
20100235106SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.09-16-2010
20100241358ANALYSIS - A method of verifying the performance of a size standard, formed of a plurality of size standard elements, used in a nucleic acid analysis method is provided. The verification is achieved by introducing the size standard to an analysis stage and performing a size based separation on the size standard. The size based separation defines an experimental position for each size standard element. A comparison is made as to whether or not the experimental position for the size standard element corresponds with expected position. The comparison allows a decision to be made on whether or not to use the size standard, which is dependent upon whether or not the experimental position of the size standard element corresponds with the expected position.09-23-2010
20100241359ESTIMATION OF DIAGNOSTIC MARKERS - The invention relates to a method for estimating concentrations or concentration changes of particular biological markers, e.g. proteins. The estimations are performed by providing a mathematical model with data from measurements of other biological markers, e.g. other proteins. Thus, instead of measuring those particular proteins they can be estimated using the model. The estimated proteins can be used together with other clinical data in another model which is able to provide information or estimations of, for example, a patient's disease.09-23-2010
20120035859METHOD AND APPARATUS FOR MULTI-PARAMETER DATA ANALYSIS - In one aspect, the present invention relates to a method 02-09-2012
20090043513METHODS AND APPARATUS FOR CHARACTERIZING POLYMERIC MIXTURES - The invention provides methods and apparatus for characterizing complex polymeric mixture of interest. Candidate solutions are eliminated from a solution space using one or more experimental measurements of a polymeric mixture of interest. The elimination step can be repeated one or more times using different experimental measurements produced by various chemical and physical protocols, so that the remaining candidate solutions converge to describe the actual polymeric mixture under investigation. Once the composition of the complex polymeric mixture has been characterized, the information thus generated can be used to facilitate, for example, the manufacture of a bio-equivalent of the complex polymeric mixture.02-12-2009
20100223013TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.09-02-2010
20100235103Method and apparatus for evaluating prothrombotic conditions - Methods and apparatus are disclosed for determining a prothombotic condition, including a condition of hypercoagulability. The determination is based on the clotting of a sample of blood or blood components which involves reacting the sample with a clotting agent and recording time and absorbance values. A slope determination is utilized to determine an indicator for a prothrombotic condition. The indicator according to embodiments, may be determined through the derivation of an angle in conjunction with the clotting analysis and slope.09-16-2010
20100324829METHOD OF SELECTING HLA-DP4 LIGANDS AND THE APPLICATIONS THEREOF - A method of selecting a test molecule that binds to HLA-DP4 by (i) incubating HLA-DP4 with the test molecule and a labeled peptide of formula (I) Z12-23-2010
20100211327Methods and Systems for Viral Diagnosis - Methods, apparatus, and software for identifying sets of genomic oligonucleotides that identify a viral family and for determining sets of probes and primers that can be used to identify members of viral families in a sample are provided. In one embodiment, the method of the present invention includes normalizing viral genomic oligonucleotide sequence data from at least one viral family, and identifying at least one oligonucleotide sequence that is unique to each viral family. An array of the identified oligonucleotide sequences is made. Primers provided by the present invention are used to amplify viral family genomic sequences in a biological sample of interest, and probes provided using the present invention, e.g., attached to an array or biochip, are then used to detect the presence of the corresponding virus(es) present in the sample by hybridization.08-19-2010
20100211326ELECTRONIC HYBRIDIZATION ASSAY AND SEQUENCE ANALYSIS - An electronic hybridization assay implements a hybridization reaction, or a sequence analysis, on sequences representative of the sequences of the molecules under examination to provide an output representative of a chemical hybridization reaction. An electronic hybridization machine implements a correlation algorithm where the correlation output provides information regarding the relationship between the molecules under examination. In one aspect, the degree of similarity between the molecules is indicated by the correlation output value. In another aspect, a locus of similarity between the molecules is indicated by a maximum value in the correlation output sequence. In a particular aspect, the sequences are encoded in an optimized format to optimize the operation of the operation of the electronic hybridization machine.08-19-2010
20100211325LAMININ BINDING SITE - The present invention in one aspect related to a ligand binding site for laminin, particularly those laminins comprising an α5 chain. The invention also encompasses binding sites on Lutheran glycoprotein (“Lu gp”) for binding laminin (“LM”) isoforms containing an α5 chain, mutant Lu gp molecules impaired at this binding site, antagonists and enhancers of the site, methods for identifying antagonists and enhancers, and uses of these molecules.08-19-2010
20130013219Determining Susceptibility To A Sudden Cardiac Event - Disclosed herein is a method of do terming the likelihood of a sudden cardiac event, such as an arrythmia, in a subject. Also disclosed is a method of determining whether a subject is at risk of a sudden cardiac event arid whether the subject would benefit from a treatment such as implantation of an ICD.01-10-2013
20130218474Benchmarks for Normal Cell Identification - Methods for determining a model that can characterize and distinguish normal cell from a diseased cell and methods for determining health or health-risk status of an individual based on a normal/health cell reference population of cells are described.08-22-2013
20120143512METHODS OF SELECTION, REPORTING AND ANALYSIS OF GENETIC MARKERS USING BROAD-BASED GENETIC PROFILING APPLICATIONS - Disclosed is a method for determining whether an individual has an enhanced, diminished, or average probability of exhibiting one or more phenotypic attributes and related methods of selecting a set of genetic markers; for providing relevant genetic information to an individual; of evaluating the probability that progeny of two individuals of the opposite sex will exhibit one or more phenotypic attributes; and for determining the genomic ethnicity of an individual.06-07-2012
20100191474ELECTRONIC NOSE DEVICE WITH SENSORS COMPOSED OF NANOWIRES OF COLUMNAR DISCOTIC LIQUID CRYSTALS WITH LOW SENSITITIVE TO HUMIDITY - Electronic nose device having a plurality of sensors composed of nanowires of columnar discotic liquid crystals, the device having low sensitivity to humidity. The device is designed to determine the composition and concentration of volatile organic compounds in a sample with very high sensitivity. Methods for use of the device in applications such as diagnosis of disease and food quality control are disclosed.07-29-2010
20120245854METHOD OF DIAGNOSING, PROGNOSING AND MONITORING ALZHEIMER'S DISEASE - The present invention provides a system and method for diagnosing, monitoring or prognosing Alzheimer's disease using at least one sensor comprising carbon nanotubes coated with cyclodextrin or derivatives thereof and/or at least one sensor comprising metal nanoparticles coated with various organic coatings in conjunction with a learning and pattern recognition algorithm.09-27-2012
20090287419AGGLUTINATION JUDGMENT METHOD - The present invention provides an agglutination judgment method includes a first step of collecting data of a transmitted light intensity from each of measuring points included in a predetermined region of the reaction pattern, a second step of calculating a parameter representing the dispersion of a transmitted light intensity in the region, and a third step of judging the agglutination or non-agglutination by comparing the parameter thus calculated with a predetermined reference value.11-19-2009
20090204339Apparatus, method and computer program product for determining confidence measures and combined confidence measures for assessing the quality of proteomic and genomic data - An apparatus, method, and computer program product are provided for determining a confidence measure for the output of a process for assessing proteomic and genomic information samples. Typically, data is received as the results from a microarryi experiment. The confidence measure is intended to determine whether the results of the experiment have been degraded due to experimental error. Several criteria are used by which quality is determined. The criteria are preferably combined into a combined quality measure in order to account for several possible sources of error.08-13-2009
20090119019Small Molecule Mimetics of Erythropoietin - The invention features computer-assisted methods for identifying molecules which will bind to the EPO receptor and act as an erythropoietin (EPO) mimetic. Preferred EPO mimetics identified using the method of the invention act as agonists of the EPO receptor in one or more in vitro or in vivo biological assays of EPO activity.05-07-2009
20090319192Measurement Facility, Sensor Unit and Further Processing Unit - A measurement facility comprises at least one sensor unit for measurement and issuing of signals and a further processing unit for receiving and further processing of signals which were measured by the at least one sensor unit, with an interface for detachable connection of the further processing unit to different sensor units. A further processing unit comprises at least one interface for establishing a detachable connection to a sensor unit, in order to form a usable inventive measurement facility. A sensor unit comprises a connection point for establishing the detachable connection to the further processing unit.12-24-2009
20090112483Protocol For Risk Stratification of Ischemic Events and Optimized Individulaized Treatment - A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit preparation of an individualized assessment of ischemic event risk and individualized treatment of a subject.04-30-2009
20090112479PATHWAY DISPLAY METHOD, INFORMATION PROCESSING DEVICE, AND PATHWAY DISPLAY PROGRAM PRODUCT - A pathway display method in an information processing device processing information includes a pathway information acquiring step (S04-30-2009
20090143994Managing Body Composition - Among other things, at least two different independent providers of body composition management services are enabled to have online access through respective graphical user interfaces to body composition information and plans that are associated with respective clients of the providers and that are stored on the server. The graphical user interfaces are different for different independent providers. At least some of the information and plans associated with the clients of the different independent providers are stored in a common format in a common database maintained by the server.06-04-2009
20110130972DEVICE FOR MEASURING CONSUMPTIONS AND THE RESPECTFUL PERFORMANCE WITH THE ENVIRONMENT - A device for measuring power consumption and performance relative to the environment of a power-consuming unit is disclosed. The device includes a data introduction module, a keyboard for inputting data of waste production in the power-consuming unit, a computing device, and a display screen. The computing device receives the data from the data introduction module and the keyboard. The computing device is also provided with a processor that includes a calculation algorithm of an ecological parameter indicative of the performance relative to the environment of the power-consuming unit. The ecological parameter is calculated as an adjusted mean of the sum of the deviations of each power consumption value with respect to a reference value.06-02-2011
20110130970SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.06-02-2011
20090112480METHOD AND APPARATUS FOR CLUSTERING GENE EXPRESSION PROFILES BY USING GENE ONTOLOGY - Provided are a method and apparatus for clustering gene expression profiles by using the Gene Ontology (GO). The method includes: selecting one or more GO terms from a GO tree; receiving gene expression data sets; classifying the gene expression data sets into groups according to the GO terms; firstly clustering gene expression data belonging to each of the groups based on a similarity of the gene expression data; and secondly clustering the gene expression data sets by using the result of the first clustering as a seed.04-30-2009
20090112482MICROARRAY DETECTOR AND SYNTHESIZER - The present invention relates to novel systems, devices, and methods comprising spatial light modulators for use in the reading and synthesis of microarrays. For example, the present invention provides micromirror systems for synthesizing and acquiring data from nucleic acid microarrays and systems for collecting, processing, and analyzing data obtained from a microarray.04-30-2009
20080270040Automated generation of multi-dimensional structure activity and structure property relationships - The present invention relates to automated generation of multi-dimensional structure activity and structure property relationships.10-30-2008
20090105959System and method for identification of individual samples from a multiplex mixture - An embodiment of an identifier element for identifying an origin of a template nucleic acid molecule is described that comprises a nucleic acid element comprising a sequence composition that enables detection of an introduced error in sequence data generated from the nucleic acid element and correction of the introduced error, where the nucleic acid element is constructed to couple with the end of a template nucleic acid molecule and identifies an origin of the template nucleic acid molecule.04-23-2009
20090105960Device for supporting diagnosis of a cancer and a device for predicting an effects of anthracycline anticancer drugs - A device for supporting a diagnosis of a cancer which provides information useful to decide whether or not an anthracycline anticancer drug should be administered to a cancer patient to be examined is disclosed. Concretely, the device is composed to be able to acquire an activity and an expression of two cyclin dependent kinases (CDK) from a malignant tumor of a cancer patient to be examined, and to acquire a CDK parameters from both of two CDKs. Furthermore the device determines sample data comprising predetermined CDK parameter, and display information of determined sample data. According to the above component, user is easily able to know whether or not a cancer of a cancer patient, whose tumor is similar to the tumor of the cancer patient to be examined, has been recurred in spite of an administration of an anthracycline anticancer drug.04-23-2009
20110238320INTERACTION FORCE CHANGE PREDICTION APPARATUS AND INTERACTION FORCE CHANGE PREDICTION METHOD - An interaction force change prediction apparatus includes: a pre-mutation combination data creation unit which creates pre-mutation combination data including a plurality of three-residue combinations, each combination having a pair of amino acid residues and one amino acid residue adjacent to one of the amino acid residues in the pair; a post-mutation combination data creation unit which creates post-mutation combination data including post-mutation three-residue combinations; an interaction score calculation unit which calculates a pre-mutation interaction score for the three-residue combinations included in the pre-mutation combination data and a post-mutation interaction score for the post-mutation three-residue combinations included in the post-mutation combination data, by reference to a three-residue combination table; and a predicted-value calculation unit which calculates a difference between the pre-mutation interaction score and the post-mutation interaction score.09-29-2011
20100299076Mass Spectrometry System - (EN) MS analysis, MS11-25-2010
20090105958Method for skeletal maturity determination - The invention is a method for estimating a skeletal maturity value of a human from a radiograph of one or more bones in the hand. The borders of the bones are represented by shape points, which are subjected to principal component analysis (PCA). Image intensities are sampled at points located relative to the shape point, and also compressed with PCA. From the features a skeletal maturity value is determined.04-23-2009
20100312485Method and arrangement for determination of the individual incretin sensitivity index of a subject - A computer-aided method for determination of a subject's individual incretin sensitivity index determines the individual metabolic situation in the form of the personal metabolic situation of the subject. The individual incretin effect factor and the effect found of the administered incretin mimetic or incretin enhancer by simulation for the mean deviation of the daily glycemia are determined with the personal metabolic situation data and recorded numerically. The corresponding effect factor of a slow-acting insulin, whose step-by-step administration is varied until the mean deviation of the daily glycemia is identical to the mean deviation of the daily glycemia determined previously by the incretin mimetic or incretin enhancer, is determined. The insulin dosage is recorded numerically. The individual incretin sensitivity index is calculated from the relationship between the dosages of the incretin mimetic or incretin enhancer determined for identical deviation of the daily glycemia and the respectively individually different insulin dosage.12-09-2010
20100312484SYSTEM FOR MONITORING OF AND MANAGING COMPLIANCE WITH TREATMENT FOR OBSTRUCTIVE SLEEP APNEA USING ORAL APPLIANCE THERAPY AND METHOD THERFOR - A system and method for monitoring of and managing compliance with treatment for obstructive sleep apnea using oral appliance therapy comprises a sensor module installed in an oral appliance, a data communications facility for communicating with the oral appliance, a control module, and a central database for storing data. Data stored on the sensor module is transferred to the data communications facility for local storage. The control module validates the locally stored temperature data and uploads the validated data into the central database. Temperature data stored in the central database may be viewed remotely via a secure computer network connection in graphical form by authorized users using role-based access controls. Authorized users may include the patient, the patient's provider, system administrators, and stake holders including insurance carriers providing medical coverage for OAT.12-09-2010
20090070044Two-Body Interaction Calculation Circuit and Many-Body Problem Calculation Device that Uses this Circuit - The object of the present invention is to provide both a two-body interaction calculation circuit that can reduce the number of arithmetic elements of a circuit for virial calculation and that can decrease circuit scale and a many-body problem calculation device that uses this two-body interaction calculation circuit, the two-body interaction calculation circuit of the present invention including: a coordinate difference calculation unit for receiving as input coordinates of center particles i, the size of a basic cell, lattice vectors, and coordinates of particles j and for calculating the difference between coordinates of a center particle i and coordinates in which the coordinates of a particle j have been converted to a mirror-image particle; a distance-squaring calculation unit for calculating the square of distances based on the difference; a function calculation unit for calculating an interaction function that depends on distance based on the square of distance; a force calculation unit for calculating force from the interaction function and the difference; a sum-total calculation unit for calculating the sum-total of force for particles i based on force; and a virial calculation unit for calculating virials based on the sum-total of force.03-12-2009
20090070045DIAGNOSIS SUPPORTING SYSTEM - A diagnosis supporting system (03-12-2009
20100312486METHODS FOR ANALYZING HIGH DIMENSIONAL DATA FOR CLASSIFYING, DIAGNOSING, PROGNOSTICATING, AND/OR PREDICTING DISEASES AND OTHER BIOLOGICAL STATES - A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised pattern recognition method, ranking individual data points from the data, wherein the ranking is dependent on the outcome of the supervised pattern recognition method, choosing multiple data points from the data, wherein the choice is based on the relative ranking of the individual data points, and using the multiple data points to determine if an unknown set of experimental data indicates a diseased condition, a predilection for a diseased condition, or a prognosis about a diseased condition.12-09-2010
20100312483ALGORITHMS FOR CALIBRATING AN ANALYTE SENSOR - Disclosed are embodiments that relate to algorithms and methods for calibrating an analyte sensor, and more particularly, to algorithms for calibrating an optical glucose sensor comprising an equilibrium fluorescent chemical indicator system. In particular, a method of detecting an analyte concentration is disclosed where a modified Michaelis-Menten equation comprising Michaelis-Menten parameters is used to characterize the signal generated by the analyte sensor.12-09-2010
20130138352SYSTEM AND METHOD FOR DETERMINING A BASELINE MEASUREMENT FOR A BIOLOGICAL RESPONSE CURVE - A system for determining a baseline measurement for a biological curve is provided. A derivation module determines a derivative response curve based on the biological response curve. A peak identification module searches the derivate response curve to identify a peak in the biological response curve. A leading baseline identification module searches the derivative response curve to identify a starting position of the peak and identifies a leading baseline in the biological response curve. The leading baseline is identified based at least in part on the starting position of the peak. A baseline determination module determines a baseline measurement for the biological response curve based at least in part on the leading baseline associated with the peak.05-30-2013
20130138353METHOD AND SYSTEM FOR DETECTING REGULATORY SINGLE NUCLEOTIDE POLYMORPHISMS - A computer-implemented method for detecting a regulatory single nucleotide polymorphism (rSNP). The method comprises determining a first score representative of a transcription factor binding affinity of a first allele, and a second score representative of a transcription factor binding affinity of a second allele. The first and second alleles are associated with a single nucleotide polymorphism (SNP), and the first score differs from the second score representing a change in the transcription factor binding affinity. A statistical significance value of the change in transcription factor binding affinity represented by the first score and the second score is then determined and compared with a threshold to determine whether the SNP is an rSNP. This disclosure also concerns a computer system and a computer program for detecting a regulatory single nucleotide polymorphism (rSNP).05-30-2013
20130138354ANALYSIS - A method of verifying the performance of a size standard, formed of a plurality of size standard elements, used in a nucleic acid analysis method is provided. The verification is achieved by introducing the size standard to an analysis stage and performing a size based separation on the size standard. The size based separation defines an experimental position for each size standard element. A comparison is made as to whether or not the experimental position for the size standard element corresponds with expected position. The comparison allows a decision to be made on whether or not to use the size standard, which is dependent upon whether or not the experimental position of the size standard element corresponds with the expected position.05-30-2013
20130138357SYSTEMS AND METHODS FOR EVALUATING A PHYSIOLOGICAL CONDITION - A method and system are provided for evaluating in patient monitoring whether a signal is sensed optimally by receiving a signal, transforming the signal using a wavelet transform, generating a scalogram based at least in part on the transformed signal, identifying a pulse band in the scalogram, identifying a characteristic of the pulse band, determining, based on the characteristic of the pulse band, whether the signal is sensed optimally; and triggering an event. The characteristics of the pulse band and scalogram may be used to provide an indication of monitoring conditions.05-30-2013
20130144536Medical Device with Wireless Communication Bus - A medical device includes an internal wireless communication bus. The medical device comprises a first physiological sensor device comprising a first radio. The medical device further comprises a patient monitor device comprising a second radio. The medical device is configured to establish an internal wireless communication between the first radio and the second radio using the internal wireless communication bus.06-06-2013
20110004411METHOD FOR ADJUSTING RESULTS OF A POLYMERASE CHAIN REACTION (PCR) INSTRUMENT - Methods of managing results of a real-time polymerase chain reaction (PCR) instrument and software associated with such methods are described herein. One disclosed method, among others, comprises calculating, from results of the real-time PCR instrument, a fluorescence signal of a sample during a cycle of a baseline period of the real-time PCR instrument. The method further comprises determining whether or not the fluorescence signal during the baseline period increases by at least a certain percentage compared to cycles outside the baseline period. The sample is flagged as a potentially high-titer sample when the fluorescence signal increases by at least the certain percentage.01-06-2011
20100332143Method, Computer Program Product and System for Enabling Clinical Decision Support - A method enables clinical decision support based on test results for a plurality of tested biomarkers. The method is executed by a data reduction module (12-30-2010
20100332140METHOD OF ASSESSING THE EATING EXPERIENCE OF A COMPANION ANIMAL - A method of assessing the eating experience of a companion animal. Further, a feeding device utilized in assessing the eating experience of a companion animal. Further, a method of modifying at least one attribute of a food product as a result of assessing the eating experience of a companion animal.12-30-2010
20100332142ANALYTE TESTING METHOD AND DEVICE FOR CALCULATING BASAL INSULIN THERAPY - Described herein are various methods to ensure safety and the compliance of therapeutic diabetes protocols. The method can be achieved by performing safeguards against hypoglycemia of the user prior to any change in basal insulin dosage based on the plurality of data.12-30-2010
20100228490Postural information system and method - A system includes, but is not limited to: one or more obtaining information modules configured for obtaining subject advisory information regarding one or more subjects of two or more postural influencers based at least in part upon postural aspects associated with the one or more subjects and spatial aspects associated with the two or more postural influencers, and one or more output modules configured for outputting output information based at least in part upon one or more elements of the subject advisory information. In addition to the foregoing, other related method/system aspects are described in the claims, drawings, and text forming a part of the present disclosure.09-09-2010
20100228495Postural information system and method including determining subject advisory information based on prior determined subject advisory information - A system includes, but is not limited to: one or more determining advisory modules configured for each of one or more first instances, determining subject advisory information regarding one or more subjects associated with the first instance based at least in part upon postural influencer status information including information involving one or more spatial aspects for each of two or more postural influencers of the one or more subjects, and one or more second determining modules configured for a second instance, based at least in part upon each of the subject advisory information associated with each of the one or more first instances, generating subject advisory information regarding one or more subjects being associated with the second instance and being posturally influenced by two or more postural influencers. In addition to the foregoing, other related method/system aspects are described in the claims, drawings, and text forming a part of the present disclosure.09-09-2010
20100332141ANALYZER APPARATUS AND METHODS FOR LUNG DISEASE - An apparatus arranged to give an output indicative of lung disease state, in particular Chronic Obstructive Pulmonary Disease (COPD). The apparatus comprises a biomarker detection unit; a patient information input unit; a memory unit; a processing unit; and an output unit. The biomarker detection unit generates biomarker information by analyzing a patient saliva sample. The biomarker information is processed with patient information relating to patient symptoms, and an appropriate output generated based on the combination of the biomarker information and the patient information. The output suitably indicates whether there is a change in the disease state, and may further include a recommendation regarding treatment for the disease according to such a change.12-30-2010
20100185398System and Method for Monitoring Athletic Performance - A system for monitoring biometric data of an athlete participating in a sporting event comprises at least one biometric sensor carried by the athlete. The sensor senses biometric data for the athlete and delivers the data to a transmitter located on the athlete. The transmitter automatically transmits the biometric data to a wireless telephony network as the athlete participates in the sporting event. The wireless telephony network, in turn, delivers the biometric data to a processing server via the Internet. The processing server receives the biometric data and transforms the data into processed biometric data for the athlete. The processed biometric data for the sporting event is available to the athlete or other authorized individuals in real time and/or any time following the sporting event at a computer connected to the Internet.07-22-2010
20100185399Method for Analyzing Clinical Trial Results for Efficacy of a Therapy - Methods of identifying, monitoring and matching patients with appropriate treatments who are at risk for developing a systemic inflammatory condition using a systemic mediator-associated physiologic test profile are provided. The methods of the present invention increase the likelihood of demonstrating clinical efficacy in clinical trial datasets.07-22-2010
20110130971SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.06-02-2011
20110022323System and Method to Determine Sigma of a Clinical Diagnostic Process - A system and method for determining a sigma of a clinical diagnostic process are disclosed. Specimen data are collected from a plurality of laboratory instruments. The specimen data are evaluated to determine a concentration and an analytical standard deviation for each data point. A clinical diagnostic process is run and patient analyte values are acquired, and a standard deviation is assigned to each patient analyte value based on the standard deviation of specimen data having a corresponding concentration. A single sigma-metric is computed based on the patient analyte assigned standard deviations, the sigma-metric representing the sigma of the clinical diagnostic process. The computed sigma-metric is reported to a user or laboratory manager.01-27-2011
20110004413METHOD AND SYSTEM FOR CALLING VARIATIONS IN A SAMPLE POLYNUCLEOTIDE SEQUENCE WITH RESPECT TO A REFERENCE POLYNUCLEOTIDE SEQUENCE - Embodiments for calling variations in a sample polynucleotide sequence compared to a reference polynucleotide sequence are provided. Aspects of the embodiments include executing an application on at least one computer that locates local areas in the reference polynucleotide sequence where a likelihood exists that one or more bases of the sample polynucleotide sequence are changed from corresponding bases in the reference polynucleotide sequence, where the likelihood is determined at least in part based on mapped mated reads of the sample polynucleotide sequence; generating at least one sequence hypothesis for each of the local areas, and optimizing the at least one sequence hypothesis for at least a portion of the local areas to find one or more optimized sequence hypotheses of high probability for the local areas; and analyzing the optimized sequence hypotheses to identify a series of variation calls in the sample polynucleotide sequence.01-06-2011
20110035156Method of evaluating gastric cancer, gastric cancer-evaluating apparatus, gastric cancer-evaluating method, gastric cancer-evaluating system, gastric cancer-evaluating program and recording medium - According to the method of evaluating gastric cancer of the present invention, amino acid concentration data on the concentration value of amino acid in blood collected from a subject to be evaluated is measured, and a gastric cancer state in the subject is evaluated based on the concentration value of at least one of Asn, Cys, His, Met, Orn, Phe, Trp, Pro, Lys, Leu, Glu, Arg, Ala, Thr, and Tyr contained in the measured amino acid concentration data of the subject.02-10-2011
20110035157BIOMASS CONCENTRATION MEASUREMENT DEVICE AND METHOD AND USE OF AN ELECTRONIC CHIP ELEMENT FOR MEASURING SAID BIOMASS CONCENTRATION - The invention relates to devices and methods for measuring a concentration of a biomass suspended in a medium. Embodiments of the device include a substrate capable of being immersed in the medium, at least two electrodes integrated in the substrate, and a processing and control circuit electromagnetically coupled to the at least two electrodes. The processing and control circuit is configured to apply an electrical potential to the at least two electrodes, the applied electrical potential generating a stationary electric charge that leads to the appearance of an electrical double layer on a surface of one of the at least two electrodes and that causes a biomass electrostatic adhesion on the surface, measure a change in capacitance of the electrical double layer in response to the biomass electrostatic adhesion, and determine the concentration of the biomass using a calibration curve that correlates the change in capacitance with the concentration.02-10-2011
20110035155PROTEIN AGGREGATION PREDICTION SYSTEMS - We describe methods for identifying aggregation-prone regions in structured—that is folded—proteins. Embodiments of the method use a local propensity for aggregation (A02-10-2011
20110035158METHODS OF AND DEVICES FOR MONITORING THE EFFECTS OF CELLULAR STRESS AND DAMAGE RESULTING FROM RADIATION EXPOSURE - Methods of and devices for detecting a measurable characteristic of the gas sample. The methods and devices are able to detect a value of or a change of measurable characteristic (e.g., such as chemical concentrations), a change of chemical compositions and/or biological responses of a living organism that are induced by a stressor. The biological responses are able to include cellular stress, damage, and immune responses. The stressor is able to include an exposure to ionizing radiation. The effects of the stressors are able to be monitored in terms of changes in the chemical concentrations and chemical compositions in an exhaled breath. The chemicals are able to function as bio-markers. The chemicals that are to be monitored are able to include nitric oxide, carbon monoxide, carbon dioxide, ethane, and other molecules related to specific disease resulting from the stressor.02-10-2011
20110035159CORRECTING BIOLOGICAL SIGNAL MEASUREMENTS FROM PARALLEL MEASUREMENT DEVICES - A computer-implemented method and apparatus for correcting data sets from microarray measurements of gene expression values made with several different microarray versions. The method comprises obtaining data sets (02-10-2011
20110040491CLASSIFICATION OF SAMPLE DATA - A classification system (02-17-2011
20110118986METHODS AND APPARATUS FOR EVALUATING GLUCOSE LEVELS AROUND A REPEATING EVENT - Methods for evaluating changes in glucose levels include selecting a repeating event, obtaining a pre-event measurement and a post-event measurement for a plurality of occurrences of the repeating event wherein a glucose change between the pre-event measurement and post-event measurement may be determined for each of the plurality of occurrences of the repeating event, and, recording unique details for each of the plurality of occurrences of the repeating event such that the unique details may be correlated with the glucose change for each of the plurality of occurrences of the repeating event.05-19-2011
20110040489Diabetes Care Host-Client Architecture and Data Management System - A host-client data sharing system manages diabetes care data. A host database, preferably web or internet based, is implemented for storing diabetes care data relating to multiple diabetics. A client or local database stores the diabetes care data relating to multiple diabetics on a personal appliance such as a PC, or a portable or handheld microprocessor-based computing device. The host database uses multiple servers for handling client interactions with the system.02-17-2011
20110040490PARAMETRIC SYSTEM FOR QUANTIFYING ANALYTE POLYNUCLEOTIDES - System for quantifying analyte polynucleotides employs computer-implemented analysis of real-time amplification data using a calibration curve defined by parametric equations.02-17-2011
20090276162SENSOR DEVICE AND SENSOR SYSTEM - The invention relates to a sensor device for fastening to human or animal bodies and to a sensor system comprising a plurality of said sensor devices. The sensor devices each comprise a sensor element and a transmission device for the wireless transmission of sensor signals to a receiving device of the sensor system. Thus, universal usability and particularly the suitability to carry out biopotential measurements preferably with automatic detection of configurations is made possible in that the sensor devices each are provided with a connecting device for the electrical connection to a neighboring sensor device and/or a position detection device for detecting the position relative to the neighboring sensor unit.11-05-2009
20110118987PREDICTIVE BLOOD SUGAR LEVEL CALCULATING DEVICE, PREDICTIVE BLOOD SUGAR LEVEL CALCULATING METHOD, AND PROGRAM THEREOF - A predictive blood sugar level calculating device acquires meal information about meal intake, calorie consumption information about calorie consumption, pulse information, and the like, calculates predictive blood sugar level change curves indicating change in blood sugar levels based on the plurality of information in a time series using predetermined numerical formulas, and combines the predictive blood sugar level change curves, thereby reducing an error between the calculated predictive blood sugar level curve and an actual change in a blood sugar level occurring in a human body.05-19-2011
20090063056System integrating machine vision, interactive module and rehabilitation equipment - A system integrating machine vision, interactive module and rehabilitation equipment primarily comprises a rehabilitation equipment, at least one image-capture device for continuously capturing images of specific limbs or a trunk of a user operating the rehabilitation equipment so as to generate digital image data, and a machine vision recognition unit for processing the digital image data into characteristic image data that can be analyzed and applied by a host computer belonging to the machine vision recognition unit. Then, the host computer can transform the characteristic image data into direction signals and velocity signals with respect to movements of the user's limbs and trunk and afterward output the signals to an interactive module.03-05-2009
20110246080GENE CLUSTERING PROGRAM, GENE CLUSTERING METHOD, AND GENE CLUSTER ANALYZING DEVICE - [Object] To provide a gene clustering tool that can perform gene clustering based on the data on gene expression level over time without a priori data forecast but with high precision.10-06-2011
20110246076Method and System for Word Sequence Processing - A method and system of conducting named entity recognition. One method comprises selecting one or more examples for human labelling, each example comprising a word sequence containing a named entity and its context; and retraining a model for the named entity recognition based on the labelled examples as training data.10-06-2011
20110087437PROCESS, SOFTWARE ARRANGEMENT AND COMPUTER-ACCESSIBLE MEDIUM FOR OBTAINING INFORMATION ASSOCIATED WITH A HAPLOTYPE - The present invention relates to a method, system and software arrangement for determining the co-associations of allele types across consecutive loci and hence for reconstructing two haplotypes of a diploid individual from genotype data generated by mapping experiments with single molecules, families or populations. The haplotype reconstruction system, method and software arrangement of the present invention can utilize a procedure that is nearly linear in the number of polymorphic markers examined, and is therefore quicker, more accurate, and more efficient than other population-based approaches. The system, method, and software arrangement of the present invention may be useful to assist with the diagnosis and treatment of any disease, which has a genetic component.04-14-2011
20110213557Assessing the effectiveness of psychiatric medication in physicians' practices - Disclosed is a method of efficiently assessing the effectiveness of psychiatric medications as administered by physicians and more specifically to a methodology that compares the effectiveness of different medications across groups of patients based on changes in mental health scores using electronic systems. Additionally, the invention delineates when changes in medications are made during the course of medical visits for a single patient.09-01-2011
20110087436METHOD AND SYSTEM FOR ANALYSIS OF TIME-SERIES MOLECULAR QUANTITIES - A method and system for analyzing a plurality of groups of time-series gene expressions including determining a time-dependent score that comprises a difference between the gene expression in the first group at a given time point and the gene expression in the second group at the given time point, determining an expected difference parameter that comprises a difference between a mean expression of the gene in a third group of samples and a mean expression of the gene in a fourth group of samples, created by randomly dividing the samples into two equal groups, comparing a difference between the time-dependent score and the expected difference parameter to a threshold at the given time point, determining the significant genes at each time point on the basis of the comparison.04-14-2011
20090312951Method for Calculation of Statistical Characteristics for a Set of Gene Expression Values - The invention is concerned with the field of analysis of data resulting from gene profiling experiments, and provides a method for calculation of statistical characteristics e.g. standard deviation values for a set of value pairs (X12-17-2009
20100228492Postural information system and method including direction generation based on collection of subject advisory information - A method includes, but is not limited to: for each of one or more instances, determining subject advisory information regarding one or more subjects associated with the instance based at least in part upon postural influencer status information including information involving one or more spatial aspects for each of two or more postural influencers of the one or more subjects, and generating one or more directions based at least in part upon each of the subject advisory information associated with each of the more than one instances. In addition to the foregoing, other related method/system aspects are described in the claims, drawings, and text forming a part of the present disclosure.09-09-2010
20090099787Abnormal Output Detection System For A Biosensor - A biosensor has an abnormal output detection system that determines whether an output signal from the redox reaction of an analyte has a normal or abnormal shape or configuration. The abnormal output detection system improves the accuracy and precision of the biosensor in determining whether an output signal has a shape or configuration that may not provide an accurate and/or precise analysis of a biological fluid. The biosensor generates an output signal in response to the redox reaction of the analyte. The biosensor normalizes the output signal and compares the normalized output signal with one or more control limits. The biosensor may generate an error signal when the normalized output signal is not within the control limits.04-16-2009
20090099783Stage Specific Prognostic In Vivo Markers of Brain Aging and Dementia - A method for the identification of treatments and preventative agents for brain aging, subjective cognitive impairment (SCI), mild cognitive impairment (MCI), Alzheimer's disease (AD) and other degenerative dementias, the method including (a) the identification of the diagnosis and stage of the subject, (b) the identification of the duration of the stage of the condition and/or disorder, (c) the identification of prognostic markers based upon a formula incorporating the duration of the condition and/or stage, (d) the prospective separation of prognostic subgroups based upon outcome wherein the outcome is defined in these conditions as progression to a subsequent stage or stages, (e) the employment of a putative prognostic marker for an appropriate period of time, based upon the formula incorporating the duration of the condition and/or stage, (f) the application of in vivo, methodology specific techniques, in conjunction with stage specific prognostic subgroups, for the appropriate time period, for the identification, prospectively, of useful markers, (g) the employment of these markers to identify useful therapeutic agents for prevention and treatment.04-16-2009
20090099782AUTOMATIC ANALYZING METHOD AND APPARATUS FOR MICROFLUIDIC SYSTEM - Provided are an automatic analyzing method and apparatus for a microfludic system. The apparatus includes means for recognizing a disc or chip in the microfludic system, performs an operation and detection by automatically loading a DB according to a recognized type, and perform quantitation of a test.04-16-2009
20120035855METHOD OF NETWORK-BASED IDENTIFICATION FOR DRUG ACTION AND/OR SYNERGY EFFECT OF MEDICINE COMBINATION - The invention provides a network-based method for confirming drug action (drug effect, synergistic reaction). The method be carried out by mapping a first drug genes/gene products subset and a second genes/gene products subset in a gene network. The second genes/gene products subset can be a second drug genes/gene products subset or a biological process genes/gene products subset. The invention also provides a tool for pre-clinical drug screening.02-09-2012
20110082648Microchip blood analyzer - A microchip blood analyzer contains a mixing unit that mixes a sample and a test reagent with each other; a detection unit that detects a reaction of the mixture, a measurement unit that measures an amount of a specific ingredient in the sample; and a judgment unit that obtains a value using an approximate expression in a least-square method by using measurement data, compares a value obtained from an approximate expression and a value of the measurement data to obtain a deviation degree, and generates an output of a measurement result when the deviation degree is a prescribed value or greater.04-07-2011
20100070186METHODS OF SCREENING FOR AND MAPPING PHENOTYPIC AND GENOTYPIC VARIATIONS IN CELLS - Described herein are methods of mapping in cultured cells a recessive genotypic or phenotypic variation to a region of a genetic sequence, methods of screening cells in. cell culture for genotypic or phenotypic variations, methods of mutagenizing cells, and methods of using genetic sequences identified by one or more methods described herein.03-18-2010
20120245855SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and/or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred.09-27-2012
20120245853Device For Adaptive Processing Of An Endocardial Acceleration Signal - Device for adaptive processing of an endocardial acceleration signal. The device continuously collects an endocardial acceleration EA signal and divides it into EA sub-signals, each over the duration of one cardiac cycle. The EA sub-signals are separated into the EA09-27-2012
20110106453Method for storing a series of measurements - A method reducing storage volume of a series of measured time-dependent parameters measured in or on the human body such as glucose values from a continuous glucose monitor while permitting retrospective reconstruction of measured data with sufficient accuracy. The series comprises a first number of measured values, and a second number of values that are stored. In this case, the second number is smaller than the first number. A first storage mode is provided, in which an interval of time between successive stored values is variable and which is adjusted on the basis of a time-based variability of the measured values. A second storage mode may also be provided, in which the interval, of time between successive stored values is constant. Embodiments of the invention include a measuring apparatus and a computer program.05-05-2011
20110246078MITOCHONDRIA KATP ION CHANNEL AS A DRUG TARGET FOR PREVENTING LIVER DISEASES AND METHODS TO SCREEN MITOCHONDRIA KATP MODULATORS - Disclosed are compositions and methods related to modulation of K10-06-2011
20100017145METHOD OF EVALUATING CANCER STATE, CANCER-EVALUATING APPARATUS, CANCER-EVALUATING METHOD, CANCER-EVALUATING SYSTEM, CANCER-EVALUATING PROGRAM AND RECORDING MEDIUM - According to the method of evaluating cancer state of the present invention, amino acid concentration data on the concentration value of amino acid in blood collected from a subject to be evaluated is measured, and a cancer state in the subject is evaluated based on the concentration value of at least one of Cys, Gln, Trp, Orn, Arg, Glu, His, Ser and ABA contained in the measured amino acid concentration data of the subject.01-21-2010
20100185397METHOD FOR IDENTIFYING NUCLEOTIDE SEQUENCE, METHOD FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE, APPARATUS FOR IDENTIFYING NUCLEOTIDE SEQUENCE, APPARATUS FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE, PROGRAM FOR IDENTIFYING NUCLEOTIDE SEQUENCE, AND PROGRAM FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE - It is intended to provide a method for identifying a nucleotide sequence necessary for expressing an affinity for a target substance in nucleotide sequences of nucleic acid molecules such as aptamers having the affinity for the target substance based on a homology of the respective nucleotide sequences and an evaluation value related to the affinity of the nucleotide sequences, and a method for predicting a secondary structure of a nucleic acid molecule containing the identified nucleotide sequence. The method for identifying a nucleotide sequence necessary for expressing an affinity for a target substance in nucleotide sequences of nucleic acid molecules having such an affinity is characterized by comprising the steps of: extracting a single-strand region from the nucleotide sequences of nucleic acid molecules by excluding nucleotides capable of forming a stem structure; and searching a motif sequence based on an evaluation value of the affinity from the single-strand region.07-22-2010
20090326830INTERPRETING DNA - Methods for establishing the genotype of a DNA sample, and methods for investigating the potential sources of a DNA sample arising from a plurality of source, are provided, the methods being based on a method including: analysing the sample to produce a data profile for the sample for a locus; proposing a suggested genotype; generating a first stage profile for the locus for the suggested genotype; adjusting the first stage profile to account for one or more factors to give a simulation profile; and comparing the data profile and the simulation profile to provide an indication of the likelihood of the data profile given the suggested genotype. The methods in effect make adjustments to take the first stage profile, potentially through one or more intervening profiles, to the simulation profile, the simulation profile being an anticipation of the data profile which would be expected to occur for that suggested genotype in practice. The methods potentially include adjustments for one or more of preferential amplification and/or stutter and/or allele drop out and/or allele drop in and/or stochastic components and/or noise and/or preferential degradation and/or the relative contributions from the sources.12-31-2009
20100010747MOLECULAR NETWORK ANALYSIS SUPPORT METHOD AND APPARATUS - A molecular network analysis support method includes receiving designation of a biological phenomenon, extracting an interaction from a molecular network, and calculating a relation strength between the designated biological phenomenon and the extracted interaction.01-14-2010
20100063746SYSTEM AND METHOD FOR DETERMINING A RISK RATING PROFILE OF SPECIFIC HORTICULTURAL ASSET PLANT SPECIES, INDIVIDUAL PLANTS AND A STAND OF PLANTS - In one embodiment, the invention may provide a system and method for determining the risk factor of individual and groups of plants by identifying a plant. Various characteristics about the plant or group of plants may then be collected and uploaded into a database. Local environmental characteristics may also be uploaded to determine the likelihood that certain adverse environmental factors may affect the plant. The uploaded characteristics of the plant and environmental factors may then be compared with predefined ratings associated with each characteristic and the ratings can be used to determine if the plant or group of plants might fail. Using this information, a risk factor for the property on which the plant or group of plants are located may be determined.03-11-2010
20100063744SMALL ORGANISM LOCOMOTOR RECORDING PROCEDURE AND DEVICE, BEHAVIORAL RECORD OBTAINED AND USE OF SAME - The system records the movement of tiny organisms housed in closed micro plates traversed by an infrared beam generating a signal as a function of the diffraction caused by the body of the microorganism. The behavior detection procedure includes processing the diffraction signal to discriminate the locomotor activity of the microorganism. The system may be used in the chronobiological field, longevity, toxicity, and pharmacology studies.03-11-2010
20120245856CHARACTERIZATION OF MOLECULES - The invention involves obtaining signatures of species (including chemical, biological, or biochemical molecules) and/or signatures of interactions between species and using them to characterize species, characterize interactions, and/or identify species that could be useful in a variety of settings. Signatures can be obtained using aqueous multi-phase partitioning and can be used to predict molecular interactions for applications such as drug discovery. A plurality of aqueous multi-phase partitioning arrangements can define an overall system providing an information-intensive signature, maximizing precision and sensitivity.09-27-2012
20120245852APPARATUS FOR CALCULATING SCORES FOR CHAINS OF SEQUENCE ALIGNMENTS - Each of a plurality of substantially co-linear alignments has a score. Each alignment may comprise a starting alignment that has been diagonally extended to meet a length requirement. Dynamic programming is performed in interalignment regions between the extended alignments to generate a corresponding set of interalignment scores. Alignment scores and interalignment scores are summed to generate a score for the entire chain of alignments. This process is repeated for multiple chains. Chains of alignments are ranked by chain score and are displayed to a user. In one embodiment, additional dynamic programming is performed at the head and tail of each chain to increase the chain score when possible. An integrated circuit that performs the method at high speed in hardware is disclosed. Techniques are disclosed that reduce the amount of interalignment dynamic programming. The method increases sensitivity and gives an order of magnitude speed improvement over NCBI-BLAST.09-27-2012
20090216459Ultrasonic System for Grading Meat Tenderness - Meat tenderness is determined by analyzing backscattered ultrasound signals. A signal envelope function computed from the backscattered ultrasound signals is used to derive a number of different parameters, which comprise a unimodal decay factor, a bimodal decay factor, a quiescence time, an event frequency parameter, and an event asymmetry index. Two or more of these factors are combined using a decision algorithm, which can be a neural network, a fuzzy logic classifier, a Bayesian classifier, a regression, an instance-based classifier, a decision tree, or a learned rule. These methods can also be applied to determine characteristics of the physiology of a live organism.08-27-2009
20090216458Biological-Information Processing Apparatus, Biological-Information Processing Method, Biological-Information Processing Program and Program Recording Medium - The present invention relates to a biological-information processing apparatus and a method, which are capable of measuring a hybridisation of a DMA chip without making use of a complex measurement configuration, at a low cost and with a high degree of accuracy, as well as relates to a program and a recording medium. An area enclosed by a spot boundary 08-27-2009
20090216457METHOD FOR IMPROVING FLUORESCENCE IMAGE CONTRAST - There is provided an improved method for enhancing fluorescence images of an object, such as a biological tissue, by selectively eliminating or reducing unwanted fluorescence from fluorophores other than the fluorophore of interest. The method is based on the measurement of the lifetime of fluorophores while preserving information related to the fluorescence intensity of the fluorophore of interest.08-27-2009
20100063742MULTI-SCALE SHORT READ ASSEMBLY - The invention generally provides methods for analyzing and constructing nucleic acid sequences and more specifically for assembling a collection of short read nucleic acid sequences to construct longer nucleic acid sequences.03-11-2010
20100063743Methods And Compositions For Base Calling Nucleic Acids - The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.03-11-2010
20100063740Rechargeable Biosensor - A rechargeable biosensor for the quantitative determination of an analyte is disclosed. The rechargeable biosensor mainly comprises a charging circuit, a charge storage circuit, and an operation circuit. The charging circuit may be selectively electrically coupled to an external power source for receiving a voltage; the charge storage circuit is electrically coupled to the charging circuit and being rechargeable by the charging circuit when the charging circuit is electrically coupled to the external power source; the operation circuit is electrically coupled to the charge storage circuit for receiving an operation voltage from the charge storage circuit, wherein the operation circuit is adapted to measure an electrical signal derived from the analyte and output a quantitative property of the analyte.03-11-2010
20110178720METHOD AND SYSTEM FOR MEASURING ENERGY EXPENDITURE AND FOOT INCLINE IN INDIVIDUALS - A method and system for measuring energy expenditure of individuals by measuring force from a plurality of foot-borne force sensitive resistors and calculating incline from a foot-borne tri-axial accelerometer.07-21-2011
20110178716Method for determining volume and hemoglobin content of individual red blood cells - Provided herein is a method for determining the volume or hemoglobin content of an individual red blood cell in a sample containing a population of red blood cells. The method may be performed on a hematology analyzer. Also provided are a hematology analyzer for performing the method and a computer-readable medium containing programming for performing the method.07-21-2011
20110178721MEANS AND METHODS FOR DETECTING ANTIBIOTIC RESISTANT BACTERIA IN A SAMPLE - The present invention provides a method for detecting and/or identifying specific bacteria within an uncultured sample, comprising steps of: a. obtaining an absorption spectrum (AS) of said uncultured sample; b. acquiring the n dimensional volume boundaries for said specific bacteria; c. data processing said AS; i. noise reducing; ii. extracting m features from said entire AS; iii. dividing said AS into several segments according to said m features; iv. calculating m07-21-2011
20110098933Systems And Methods For Processing Oximetry Signals Using Least Median Squares Techniques - Methods and systems are disclosed for determining information from a signal using least median squares techniques, including determining blood oxygen saturation measurements based at least in part on photoplethysmograph signals. In an embodiment, a Lissajous figure is generated based on multiple measurements and least median squares techniques may be used for one or more of: determining information, assessing measurement confidence, filtering measurements, and choosing a regression analysis technique.04-28-2011
20100057371DETERMINATION OF THE INTEGRITY OF RNA - Methods, systems, and apparatus make a determination of a level of integrity of a sample of biomolecules. For example, the determination of the integrity of RNA in a sample may be done in a fast and reproducible manner, such that the user can be assured of accuracy of a test (e.g. quantitative polymerase chain reaction qPCR) on the sample and compare results of different samples. The determination of integrity of an RNA sample is performed by comparing a size profile to reference size profiles (degradation standards) obtained from degradation over different lengths of times. As the reference scale of the level of integrity is derived from the actual degradation that occurs in a sample, high accuracy, reproducibility, and efficiency is provided.03-04-2010
20100057370Nucleotide Sequence Screening - A system for screening nucleotide sequences, a method therefor, a program, a recording medium, and a server on which the screening of nucleotide sequences is executed. The solution comprises a step of storing target nucleotide sequence data and a probe nucleotide sequence, a step of generating complementary sequence data from a probe nucleotide sequence that may be bound to the target nucleotide sequence, and storing a maximum acceptable edit distance between the target nucleotide sequence and the probe nucleotide sequence, a step of reading out each nucleotide sequence data and the maximum edit distance from each storing unit, and evaluating the binding possibility of the target nucleotide sequence data and the complementary sequence data in descending order of edit distance, and a step of storing the result of the binding evaluation in a storage unit.03-04-2010
20100057368Biological Systems Analysis - Disclosed are methods for the practice of systems pharmacology, systems toxicology, and systems pathology using patterns, such as images, reflective of the biological state of subjects such as humans or experimental mammals. The patterns are generated from data obtained from one or more samples from one or more subjects by applying certain data treatment techniques, and are reflective of the biochemistry of the subjects. The patterns are used in drug selection and discovery, assessment of toxicity and drug efficacy, segmentation of populations, discovery of disease subtypes, as surrogate end points, in the assessment of therapeutic options, and for diagnosis and prognosis of disease.03-04-2010
20110153222OPTIMIZED PROBE SELECTION METHOD - The present invention provides methods for optimizing oligonucleotide hybridization probes for use in basic and clinical research. Specifically, the invention involves hybridizing serially diluted genomic sample to the oligonucleotide probes on the array, such that a signal intensity is produced for each of the probes; computationally identifying optimized probes which exhibit signal intensities that correspond to the serial dilutions of genomic sample and are reproducibly strong relative to non-optimized probes.06-23-2011
20100070194METHODS FOR RAPID IDENTIFICATION AND QUANTITATION OF NUCLEIC ACID VARIANTS - There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass measurement of resulting amplification products by mass spectrometry, and determination of the base compositions of the amplification products.03-18-2010
20100070196Blood Glucose Tracking Apparatus and Methods - A measurement module for glucose testing includes a glucose testing measurement module housing, a test strip receptacle formed in the housing, and a connector portion formed in the housing and shaped to permit mechanical removable attachment of the housing to a hand-held computer. Electronics determine the amount of glucose present in a sample of body fluid, when the test strip is positioned in the receptacle and the body fluid is placed on a test strip, and communicate the glucose amount to the hand-held computer via the connector portion.03-18-2010
20100070193GEOLOCATION SYSTEM AND METHOD FOR DETERMINING MAMMAL LOCOMOTION MOVEMENT - An example geolocation system for mounting on a mammal incorporates simple sensing sleeves on the calves of the body support members, combined with an accelerometer based gravity direction and force sensing at the center of mass of the body. The example system is connected to a digital processing unit and a battery power supply to integrate the sensing to determine kinetic and potential energy of the body locomotion over time in a method that integrates out the aperiodic motion of the body about the center of mass, and uses the residual motion to measure the center of mass locomotion from a known point.03-18-2010
20100070187HUMAN RECOGNITION APPARATUS AND HUMAN RECOGNITION METHOD - Provided are a human recognition apparatus and a human recognition method identifying a user based on a walking pattern. The human recognition apparatus includes a detecting unit detecting a vibration according to a user's walking, and outputting an electric signal, a pattern calculating unit acquiring a walker's walking pattern from the electric signal, and a user determining unit comparing the walking pattern with a previously measured reference data by user and identifying the user based on the comparison result. The human recognition apparatus and the human recognition method are robust against peripheral noise and can increase an acceptance rate through a simple structure and procedure by using the waling pattern, which is one-dimensional time information requiring no vast data throughput, as the user identification data.03-18-2010
20100070184METHOD FOR DETERMINING RESISTANCE OF HIV TO PROTEASE INHIBITOR TREATMENT - The present invention provides methods and devices for predicting whether an HIV-I is likely to have a reduced susceptibility to an antiviral drug based on the HIV-I's genotype. In one aspect, the invention provides methods comprising determining whether a mutation or combination of mutations associated with altered susceptibility to protease inhibitors are present, as disclosed herein, thereby assessing the effectiveness of tipranavir therapy in the HIV-infected subject. Computer implemented methods comprising determining HIV-I's altered susceptibility are provided.03-18-2010
20110077869CIRCUIT FOR DETECTING ANALYTES VIA NANOPARTICLE-LABELED SUBSTANCES WITH ELECTROMAGNETIC READ-WRITE HEADS - A circuit for detecting antigens on biosample tracks comprising a processor, an electromagnetic write head for magnetizing nanoparticles attached to the antigens via antibodies in response to a write signal from the processor, and a first amplifier for supplying power to the write head. The circuit further comprises a magneto-resistive read sensor for detecting the magnetized nanoparticles upon receiving a read signal from the processor, and a second amplifier for supplying power to the read sensor. The write head and read sensor may be part of a head module in a magnetic tape drive. Nanoparticles of differing magnetic properties may be selectively paired with antibodies associated with different antigens to allow different antigens to be detected upon a single scan by the read-sensor.03-31-2011
20110153221DIAGNOSTIC SYSTEM FOR SELECTING NUTRITION AND PHARMACOLOGICAL PRODUCTS FOR ANIMALS - An analysis of the profile of a non-human animal comprises: a) providing a genotypic database to the species of the non-human animal subject or a selected group of the species; b) obtaining animal data; c) correlating the database of a) with the data of b) to determine a relationship between the database of a) and the data of b); c) determining the profile of the animal based on the correlating step; and d) determining a genetic profile based on the molecular dietary signature, the molecular dietary signature being a variation of expression of a set of genes which may differ for the genotype of each animal or a group of animals Nutrition and pharmalogical assessments are made. Reporting the determination is by the Internet, and payment for the report is obtained through the Internet.06-23-2011
20110153220PROCESSING OF BIOLOGICAL GROWTH MEDIA BASED ON MEASURED MANUFACTURING CHARACTERISTICS - This disclosure is directed to information management techniques that may be used during automated processing of biological growth media. In one embodiment, a method comprises reading an identification element associated with a biological growth medium, identifying manufacturing information associated with the biological growth medium based on the identification element, wherein the manufacturing information includes one or more manufacturing variables measured from the biological growth medium when the biological growth medium was manufactured, adjusting one or more processing parameters associated with processing of the biological growth medium based on the manufacturing variables measured from the biological growth medium when the biological growth medium was manufactured, and processing the biological growth medium in an automated system based on the processing parameters.06-23-2011
20110071766METHOD AND SYSTEM FOR DETERMINING A THRESHOLD FOR SPIKE DETECTION OF ELECTROPHYSIOLOGICAL SIGNALS - A method is provided for determining a threshold (03-24-2011
20110071764Biological Cell Sorting and Characterization Using Aerosol Mass Spectrometry - Among other things, methods, systems, apparatus for performing on-the-fly apportionment are described. In particular, spectrum data associated with a particle is acquired in real-time. The acquired real-time spectrum data is analyzing in real-time to classify the particle. Analyzing the data in real-time includes comparing the acquired spectrum data with a library of known mass spectral fingerprints to obtain a match.03-24-2011
20110077870BLOOD CELL COUNTER, DIAGNOSIS SUPPORT METHOD AND COMPUTER PROGRAM PRODUCT - A blood cell counter apparatus comprising: a detector for detecting blood cells in blood of a subject; and a controller for obtaining, based on a detection result by the detector, first analytical information about nucleated red blood cells in the blood, and second analytical information about granulocytes in the blood or third analytical information about platelets in the blood, and for outputting diagnosis support information for supporting prognosis of the subject, based on the first analytical information and on the second analytical information or the third analytical information that have been obtained. A method and computer program product are also disclosed.03-31-2011
20110071765Device and Method for Alleviating Postprandial Hyperglycemia - Embodiments of the present disclosure are directed to methods, systems and devices for alleviating postprandial hyperglycemia, as well as to methods and devices for sustained medical infusion of fluids, using, for example, skin securable insulin dispensing systems/devices.03-24-2011
20110060529TISSUE INHIBITOR OF MATRIX METALLOPROTEINASES TYPE-1 (TIMP-1) AS A CANCER MARKER - The present invention describes a method for determining whether an individual is likely to suffer from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.03-10-2011
20120303285METHOD AND SYSTEM FOR COMPARATIVE GENOMICS - A method and system for representing a similarity between at least two genomes that includes detecting gene clusters which are common to the at least two genomes and representing the common gene clusters in a PQ tree. The PQ tree includes a first internal node (P node), that allows permutation of the children thereof, and a second internal node (Q node), that maintains unidirectional order of the children thereof.11-29-2012
20120303284DETERMINATION OF TIMING OF CHEMOTHERAPY DELIVERY - A system and method for determination of one or more favorable time(s) for chemotherapy or other pharmacological treatment delivery analyze time-dependent fluctuations of at least one biological variable measured in blood samples obtained from clinical patients and determine one or more favorable times for the pharmacological treatment of the patient. In some examples, the biological variables are immune variables.11-29-2012
20120303283Polymerase Preference Index - Disclosed is a method for calculating a Polymerase Preference Index (PPI) for potential primers for DNA sequencing and/or amplification, and thereby increasing the efficiency of DNA sequencing and/or amplification performed using primers selected according to their PPI number.11-29-2012
20120303282Melatonin Suppression Extent Measuring Device - The present invention relates to a melatonin suppression extent measuring device, comprising: a light receiving unit, a first processing unit, a first memory unit, a second processing unit, a second memory unit, a display unit, and a power management unit, wherein the light receiving unit is able to receive a light signal and transmit the light signal to the first processing unit; The first processing unit can process the light signal to a spectral data, and furthermore, the second processing unit can process the spectral data to a percent value of melatonin suppression and show the percent value of melatonin suppression in the display unit, so that human can exactly know how many melatonin suppression extent are caused by the light environment which is exposing himself body.11-29-2012
20110060530Analyte Signal Processing Device and Methods - Methods and devices for determining a measurement time period, receiving a plurality of signals associated with a monitored analyte level during the determined measurement time period from an analyte sensor, modulating the received plurality of signals to generate a data stream over the measurement time period, and accumulating the generated data stream to determine an analyte signal corresponding to the monitored analyte level associated with the measurement time period are provided. Systems and kits are also described.03-10-2011
20110060531BLOOD VOLUME MEASURING METHOD AND BLOOD VOLUME MEASURING APPARATUS - A blood volume measuring method includes: acquiring data of stroke volume variation at each respiratory rate, and storing the acquired data in a first buffer; reading an N1 number of the data stored in the first buffer, from the first buffer, and storing the N1 number of the data in a second buffer; excluding a part of the data stored in the second buffer, a value of each of which exceeds a first upper limit or falls below a first lower limit, from the data stored in the second buffer, and storing the other of the data stored in the second buffer, in a third buffer; acquiring a deviation of each of the data stored in the third buffer, from a median value of the data stored in the third buffer, excluding a part of the data stored in the third buffer, the deviation of each of which exceeds a second upper limit or falls below a second lower limit, from the data stored in the third buffer, and storing the other of the data stored in the third buffer, in a fourth buffer; determining whether N2/N1 is within an allowable value or not, wherein the N2 is a number of the data stored in the fourth buffer; and when it is determined that the N2/N1 is within the allowable value, calculating data of average stroke volume variation based on the data stored in the fourth buffer.03-10-2011
20110010103RAPID METHOD OF PATTERN RECOGNITION, MACHINE LEARNING, AND AUTOMATED GENOTYPE CLASSIFICATION THROUGH CORRELATION ANALYSIS OF DYNAMIC SIGNALS - The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of determining whether a genotype is present in a biological sample. The present invention includes methods and systems for determining whether a genotype is present in a biological sample, through generating a dynamic profile an unknown genotype, correlating the dynamic profile to an average profile for a known genotype to generate a correlation value, and determining whether the correlation value falls within an acceptable threshold to determine if the unknown genotype is the known genotype. The present invention also relates to methods and systems for generating a training set to allow a machine to recognize a known genotype from within a class of known genotypes through generating dynamic profiles of a known genotype, averaging the dynamic profiles to generate an average profile for the genotype, and correlating the dynamic profiles of the genotype with an average profile for each known genotype in a class of genotypes to generate a correlation vector. The training set generated by these methods and systems may be used to assist in identification of unknown genotypes.01-13-2011
20110010105METHODS AND SYSTEMS FOR DETECTING THE HYDRATION OF SENSORS - A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.01-13-2011
20110010104METHODS AND SYSTEMS FOR DETECTING THE HYDRATION OF SENSORS - A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.01-13-2011
20110010100FUNCTIONAL DOMAIN ANALYSIS METHOD AND SYSTEM - One embodiment of the present disclosure relates to methods for assessing the biological effects of a test agent or test condition on a test sample by comparing one or more characteristics of the biomarkers of the test sample with that of one or more reference samples and assessing the biological effects of the test agent or test condition based on the biological effects of one or more reference agents or reference conditions on the one or more reference samples, as well as computer program products for executing such methods, computer readable storage media encoding such computer programs, and computer systems for performing such methods.01-13-2011
20120203469METHOD OF EVALUATING TOXICITY LEVEL OF A PATIENT UNDERGOING A CANCER TREATMENT - This invention relates to a method and a system of evaluating toxicity level of a patient undergoing a cancer treatment protocol. Patient's related data including biomarkers of toxicity level caused by said cancer treatment are received. These biomarkers of toxicity level are then compared with a range of reference biomarkers of toxicity level caused during a similar cancer treatment. Finally, an alert signal is issued in case the biomarkers of toxicity level fall outside said range of reference biomarkers of toxicity level.08-09-2012
20100262375METHOD AND APPARATUS FOR FORMING A HOMEOSTATIC LOOP EMPLOYING AN APTAMER BIOSENSOR - A novel architecture solid-state biosensor for label-free detection of vascular endothelial growth factor (VEGF) hybridization is presented. The new device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. The detection mechanism is based on an electrochemical binding of circulating VEGF to an immobilized VEGF aptamer; whereby binding of these two compounds modulates the threshold voltage of a novel circuit, changing the impedance (capacitance) of the circuit. This novel circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the VEGF molecules and the aptamer. An apparatus forming a fluid cell is configured so as to enable the flow for delivering VEGF samples onto the active surface of the chip. The device has an array of parallel capacitors which act as an integrated, individual counter-electrode, computational apparatus which employs the sensory output over the time domain so as to enable detection, reporting and formation of a homeostatic loop for VEGF measurements. Moreover, this detector is able to provide an accurately measured and quantifiable rate of change of the VEGF molecules in-vivo, providing real time feedback of this important biomarker which may be used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden.10-14-2010
20100262376APPARATUS, METHOD AND PROGRAM FOR ANALYZING NUCLEIC ACID BASE SEQUENCE AND BASE MODIFICATION - Provided is an apparatus by which a nucleic acid may be analyzed quickly and precisely. Specifically, provided is an apparatus for analysis of a nucleic acid including: a processing unit for creating, based on a total base composition of a nucleic acid, a plurality of base composition sets, creating a hierarchical structure in which the base composition sets are hierarchized in ascending order of a number of bases in a partial base composition at a terminal position, and further creating connection relations between each of the base composition sets, and another base composition set having, at the terminal position, a partial base composition obtained by adding one base to a partial base composition at the terminal position of each of the base composition sets; a processing unit for calculating, for each of the partial base compositions, a predicted mass value of a corresponding product ion, and imparting a weight to each of the base composition sets based on a comparison between the predicted mass value and an actual mass value of a product ion derived from the nucleic acid; and a processing unit for selecting one of base composition sets belonging to each hierarchy while following the connection relations from an outermost hierarchy in the hierarchical structure, based on a weight imparted to each of the base composition sets, to thereby determine a base sequence sequentially from a terminal base of the nucleic acid.10-14-2010
20080234947SCIENTIST DOMAIN-CENTRIC USER INTERFACE AND ENABLING "SOFT" TRANSLATION - The scientist domain-centric user interface system may prompt the user to supply scientist-centric information expressed utilizing terminology of a scientific domain, such as biology or analytical chemistry. A translation system then generates control parameters to control the search algorithm, thus relieving the user from having to learn how select and configure the algorithm control parameters directly.09-25-2008
20080234946PREDICTIVE RADIOSENSITIVITY NETWORK MODEL - This invention is a model that simulates the complexity of biological signaling in a cell in response to radiation therapy. Using gene expression profiles and radiation survival assays in an algorithm, a systems model was generated of the radiosensitivity network. The network consists of ten highly interconnected genetic hubs with significant signal redundancy. The model was validated with in vitro tests perturbing network components, correctly predicting radiation sensitivity 2/3 times. The model's clinical relevance was shown by linking clinical radiosensitivity targets to the model network. Clinical applications were confirmed by testing model predictions against clinical response to preoperative radiochemotherapy in patients with rectal or esophageal cancer.09-25-2008
20080234942Analyzing Body Tissue - The invention describes a method for analysing a body tissue sample, the method comprising irradiating the tissue sample (09-25-2008
20080234945Means and Methods for Analyzing a Sample by Means of Chromatography-Mass Spectrometry - The present invention relates to a method for analyzing at least one test sample, wherein said test sample comprises at least one compound, said method comprising the steps of: a) providing at least one test sample comprising at least one compound; b) determining said at least one compound in said test sample whereby raw results are generated; and c) analyzing the raw results obtained in step b), wherein the analysis of said at least one test sample is accompanied by an analysis of at least one reference sample; and wherein the test sample and the reference sample are analyzed in an identical sequence in each step of the method. Moreover, the present invention further encompasses a system for carrying out said method comprising operatively linked to each other: (a) means for determining a compound; (b) means for monitoring process parameters, (c) means for analyzing raw results obtained from the means according to (a), wherein said means for analyzing raw results comprise: (i) a first database comprising raw results received from the means according to (a); (ii) a second database comprising monitored process parameters received from the means according to (b); (iii) a third database comprising rules for evaluating the raw results; and (iv) a fourth database comprising allocated results of identified compounds; wherein at least the second, third and fourth database are operatively linked to the first database.09-25-2008
20080234941Method of Designing Sirnas for Gene Silencing - The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.09-25-2008
20100280759MASS SPECTROMETER OUTPUT ANALYSIS TOOL FOR IDENTIFICATION OF PROTEINS - Methods and apparatus for consolidation and visualization of a dataset output from a mass spectrometer. The number of proteins identified in a mass spectrometry experiment may be systematically reduced by identifying and excluding proteins which may not be necessary to explain the observed peptides in a sample. Peptide counts from excluded proteins may be redistributed to non-excluded proteins to preserve total observed peptide counts. The consolidated dataset may be represented as a data structure having a plurality of cells arranged into rows and columns. Visual parameter values may be assigned to various cells in the data structure to emphasize particular features of the data. Data from multiple samples may be arranged in sets of columns in the data structure, and difference scores may be calculated to determine peptide expression differences between the multiples samples. The difference scores may be displayed using textual and/or graphical representations to facilitate data analysis.11-04-2010
20100280763BIOINFORMATIC TRANSACTION SCHEME - Secure network transaction system obtains user-authorized genetic term or bioinformatic profile, and transacts online service according to genetically-based user medical or other risk determined therefrom. Insurance policy, promotional offer, or other service may dynamically address genetically-based condition. Bioinformatic data classifies user per personal mask which filters subset of user genetic sequence. Risk profile may be calculated according to actuarial statistics, genetics and/or heredity using non-discriminatory rules specified for users in temporal or jurisdictional groups. User transactions are modifiable according to bioinformatic data representing genetically-based risk increase or decrease. Data is securely processed, modulated, and stored by network server for remote access and transaction using various portable user devices.11-04-2010
20100114496Compositions and methods for surface abrasion with frozen particles - Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.05-06-2010
20100262378Cytological Analysis by Raman Spectroscopic Imaging - A method for generating an image of a sample that is informative of the disease state of a cell in the sample. A sample including the cell is irradiated with monochromatic light. The Raman scattered light is assessed. A digital brightfield image of the Raman scattered light is generated and combined with the Raman scattered light emitted by the cell whereby the Raman scattered light is informative of the disease state of the cell in the sample. The method can also be used to determine the metabolic activity of the cell, the inflammatory status of the cell and/or the infected status of the cell in the sample.10-14-2010
20100262377EMG AND EEG SIGNAL SEPARATION METHOD AND APPARATUS - This invention consists of a method and apparatus for separation of the facial electromyogram (EMG) and the electroencephalogram (EEG) implemented in an index for assessing the level of consciousness during general anaesthesia. The surface EEG/EMG signal is collected from three electrodes (10-14-2010
20100262374Systems and methods for analyzing nanoreporters - Methods, computers, and computer program products for detecting the presence of a probe within a sample overlayed on a substrate are provided. The probe comprises a plurality of spatially arranged labels. A data storage module stores a plurality of light images, where each light image has light from the sample at a corresponding wavelength range in a plurality of different wavelength ranges. A label identification module identifies a plurality of labels in the plurality of light images that are proximate to each other on the substrate. A spatial order of the plurality of labels determines a string sequence of the plurality of labels. A probe identification module determines whether the string sequence of the plurality of labels comprises a valid reporter sequence.10-14-2010
20110161012READERS AND COMPUTER PROGRAM PRODUCTS THAT COOPERATE WITH SINGLE-USE EXTERNAL DOSIMETERS FOR USE IN RADIATION THERAPIES - Methods, systems, devices, and computer program products include positioning single-use radiation sensor patches that have adhesive means onto the skin of a patient to evaluate the radiation dose delivered during a treatment session. The sensor patches are configured to be minimally obtrusive and operate without the use of externally extending power cords or lead wires.06-30-2011
20100004874GENE DISCOVERY THROUGH COMPARISONS OF NETWORKS OF STRUCTURAL AND FUNCTIONAL RELATIONSHIPS AMONG KNOWN GENES AND PROTEINS - The present invention also relates to natural language processing and extraction of relational information associated with genes and proteins that are found in genomics journal articles. To enable access to information in textual form, the natural language processing system of the present invention provides systems and methods for extracting and structuring information found in the literature in a form appropriate for subsequent applications.01-07-2010
20100004871Identities, specificities, and use of twenty two (22) differentially expressed protein biomarkers for blood based diagnosis of breast cancer - The present invention discloses twenty two 22 protein biomarkers of breast cancer. More specifically, the present invention discloses the identities, specificities, and uses of up to twenty two (22) protein biomarkers in blood serum for distinguishing between patients with earlier and later stages of breast cancer, patients with benign breast diseases or abnormalities, and normal individuals lacking breast abnormalities.01-07-2010
20120203464NORMALIZED CONTEXTUAL PERFORMANCE METRIC FOR THE ASSESSMENT OF FATIGUE-RELATED INCIDENTS - A normalized contextual performance metric quantifies the susceptibility of fatigue-related risk in a fatigue environment with activities conducted within a fatigue level range of interest. Fatigue incidents are quantified by one of a plurality of values associated with fatigue-incident measurement. Activities are quantified by one of a plurality of values associated with activity measurement. A normalized contextual performance metric is determined by identifying a fatigue level range of interest, summing all values of incidents occurring at the fatigue level range of interest, summing all values for relevant activities occurring at the fatigue level range of interest, and then dividing the first sum by the second. The normalized contextual performance metric thereby allows operational managers to assess risk of fatigue incidents by monitoring activities and fatigue levels within the fatigue environment.08-09-2012
20120203468SAMPLE PROCESSING APPARATUS, METHOD OF OUTPUTTING PROCESSING RESULT BY SAMPLE PROCESSING APPARATUS, AND COMPUTER PROGRAM PRODUCT - Disclosed is a sample processing apparatus, comprising: a sample processing unit for processing a sample with an auxiliary item used to process the sample; an output device for outputting a processing result by the sample processing unit; and a controller for determining whether or not the auxiliary item is appropriate for the sample processing by sample processing unit, and controlling, when determining that the auxiliary item is not appropriate for the sample processing by the sample processing unit, the output device so as to output the processing result and reliability information showing that the processing result has a low reliability. Also disclosed is a method for outputting the processing result by the sample processing apparatus and a computer program product.08-09-2012
20120203467SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and/or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred.08-09-2012
20120203466SYSTEM AND METHOD FOR IDENTIFYING DISEASE-INFLUENCING GENES - A system and method for using individuals' behavioral and environmental information in conjunction with their gene sequences to find drug candidates and drug targets. Individuals designated as having a high risk for developing a particular disease are each given a remotely programmable apparatus. Queries related to the individuals' behavior and environment are sent from a server to the remotely programmable apparatuses. The individuals' responses to the queries and any physiological information are sent back to the server. The process of collecting individuals' information can take place over a period of time to ensure accurate data and to allow researchers to observe progression of the disease. A data mining program on the server analyzes the individuals' behavioral and environmental information, as well as their gene sequences.08-09-2012
20120203465SYSTEMS, METHODS AND PROGRAM PRODUCTS FOR COLLECTING AND ORGANIZING HEALTH DATA - One example embodiment of the invention is a system for collecting, measuring and outputting health data including a plurality of readers that each determine a plurality of different biomarker measurements from a bodily fluid sample, the test readers communicating test data sets over a network. A central computer is linked to each of the plurality of test readers and receives the test data set, the central computer associates at least a first security key with the test data set. The central computer responds to a first request for a test output report that includes the first security key and retrieves the corresponding test data set. The central computer prepares a test output report that includes a plurality of bodily fluid test measurements and transmits it over a network.08-09-2012
20120065895METHOD FOR MONITORING AN INDIVIDUAL'S FAT METABOLISM STATE - Method of monitoring energy consumption of an individual in an information system, comprised of periodically determining the energy balance of the individual by measuring body fat percentages (or body fat mass) at least at three consecutive moments of time and calculating change of body fat percentages (body fat mass) from two consecutive moments of time, and calculating the trends of the individual's energy balance from the changes of body fat percentages (body fat mass) and determining from the trend whether the individual is in the stage of burning or accumulating fat. The information system automatically generates recommendations for controlling energy balance based on the trends of changes of the energy balance.03-15-2012
20120065894MEDICAL SYSTEM AND METHOD FOR PROVIDING GLYCEMIC CONTROL BASED ON GLYCEMIC RESPONSE INFORMATION - A medical device for providing information for glycemic control is provided, wherein the device comprises a storage unit arranged to store information on an initial dose of insulin and to store information on a blood glucose level measured after the initial dose of insulin was administered and after specific food was consumed, and a determining unit arranged to determine a subsequent dose of insulin to be administered before the specific food is consumed based at least on said information on the initial dose of insulin and said information on the blood glucose level.03-15-2012
20090222212 ANALYSIS OF MIXED SOURCE DNA PROFILES - A method of analysing DNA samples from mixed sources includes i) obtaining an observed result relating to a value set for a characteristic of the DNA; ii) randomly selecting a selected value set for that DNA characteristic and generating an expected result from that selected value set; iii) comparing the observed result and the expected result and quantifying the difference there between. The method also includes iv) considering the selected value set to be the optimal match; v) randomly selecting a different selected value set and generating another expected result from that selected value set; vi) comparing the observed result with the another expected result and quantifying the difference there between; vii) replacing the existing optimal value set with the different selected value set of step v) if a criteria is met. The method further includes viii) repeating steps v), vi) and vii) at least 10 times; ix) the last optimal match being taken to be the optimal match for the value set for the DNA.09-03-2009
20090187349Consumption Monitoring Device - Described is a consumption monitoring device for monitoring the amount of consumables consumed by an animal during a monitoring period. More specifically, the consumption monitoring device measures the weight of the consumables, which are contained within a receptacle, and detects any change in the weight, such as when additional consumables are placed within the receptacle or when the animal consumes all or some of the consumables. The device calculates various values based on these changes in weight, at least one of which indicates the amount of consumables consumed by the animal. The device displays this calculated value such that the user is informed of the amount of consumables consumed by the animal within the monitoring period. This information assists the user in maintaining the animal on a desired feeding program.07-23-2009
20090143996AIRWAY SENSOR - An airway sensor includes a gas analyzing apparatus for analyzing at least one respiratory gas and a connecting unit for communication with a remotely located host device. The gas analyzing apparatus connected to a sensor electronics and which sensor electronics is also common for flow measuring device for measuring respiratory gas flow and pressure measuring device for measuring respiratory airway pressure when connected to said sensor electronics.06-04-2009
20090143995System and Method for Management and Evaluation of Genotyping Data - Provided are systems and methods for improving efficiency in high throughput genotyping operations by implementing a unique workflow management architecture that permits faster and more accurate determination and evaluation of genotyping and haplotyping, and software to accomplish the same. The system provides a user with a highly-accurate summary and multiple-field breakdown of panels of genotyping data samples for batch approval and batch selection of ambiguous or potentially unique sample sets which can be selected for further analysis. Also provided are tools for evaluating and improving the operation of a genotyping laboratory to maximize the testing and typing of the significant quantities of raw data used in genotyping that are produced in high-throughput laboratory environments.06-04-2009
20110213560System, method, and computer product for exon array analysis - In one embodiment, a method for analyzing data generated by probe arrays is described that comprises receiving user selections of two or more data files and an identification of one or more subsets of intensity values acquired from a biological probe array. The method includes iteratively opening each data file, identifying the selected subset of intensity values associated with each open data file, determining parameters for processing, storing the parameters and the identified intensity values, and closing the open data file prior to the subsequent iteration. The method then includes processing the stored intensity values using the parameters to identify one or more biological events.09-01-2011
20110213561METHOD FOR TESTING PERITONEUM FUNCTION AND A PERITONEAL DIALYSIS PLANNING APPARATUS - The present invention is a peritoneal function testing method characterized by using a ratio MTAC09-01-2011
20110213558METHOD FOR PREDICTING ACTIVATION ENERGY USING AN ATOMIC FINGERPRINT DESCRIPTOR OR AN ATOMIC DESCRIPTOR - The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors. Specifically, the invention provides a method of predicting the activation energy either for cytochrome P450-mediated hydrogen abstraction or for tetrahedral intermediate formation in cytochrome P450-aromatic hydroxylation using equations including effective atomic descriptors. The method of the invention can rapidly predict activation energy for phase I metabolites at a practical level without having to perform a docking experiment between any additional CYP450 and the substrate, or a quantum mechanical calculation, thereby making it easier to develop new drugs using a computer. Also, the present invention may propose a strategy for increasing the bioavailability of drugs through the avoidance of metabolites based on the possibility of drug metabolism. Furthermore, the method of the present invention proposes new empirical approaches which can also be easily applied to activation energies for various chemical reactions, and makes it possible to explain physical and chemical factors that determine activation energy. In addition, through the prediction of activation energy according to the present invention, it is possible to predict i) metabolic products, ii) the relative rate of metabolism, iii) metabolic regioselectivity, iv) metabolic inhibition, v) drug-drug interactions, and vi) the toxicity of a metabolite.09-01-2011
20090082972CODING PATTERN HAVING CELL TRANSLATIONS IDENTIFIABLE IN DIFFERENT ORIENTATIONS - A substrate having a coding pattern disposed on a surface thereof. The coding pattern comprises: a plurality of target elements defining a target grid; a plurality of data elements contained in each cell of the grid; and a plurality of tags. Each tag is defined by a plurality of contiguous cells and comprises respective tag data encoded by data elements. Each cell comprises a pair of registration symbols, each encoded by a respective set of the data elements. The set of data elements identifies a translation of the cell relative to a tag containing the cell. Further, each set of data elements maps to a first translation code symbol value when read in a first orientation, and maps to a second translation code symbol value when read in a second orientation. Thus, the translation of the cell relative to the tag is identifiable in either of the first or second orientations.03-26-2009
20090024332DIAGNOSING INAPPARENT DISEASES FROM COMMON CLINICAL TESTS USING BAYESIAN ANALYSIS - A system and method of diagnosing diseases from biological data is disclosed. A system for automated disease diagnostics prediction can be generated using a database of clinical test data. The diagnostics prediction can also be used to develop screening tests to screen for one or more inapparent diseases. The prediction method can be implemented with Bayesian probability estimation techniques. The system and method permit clinical test data to be analyzed and mined for improved disease diagnosis.01-22-2009
20110257894METHOD FOR DECONVOLVING SINGLE-MOLECULE INTENSITY DISTRIBUTIONS FOR QUANTITATIVE BIOLOGICAL MEASUREMENTS - A method for quantifying fluorescent puncta comprising acquiring at least one first intensity distribution comprising fluorescence intensity values from a plurality of first fluorescent puncta; acquiring at least one second intensity distribution comprising fluorescence intensity values from a plurality of second fluorescent puncta, wherein each second fluorescent puncta has a determined number of fluorescent emitters; determining the relationship between the first and second intensity distributions; and fitting the second intensity distribution to the first intensity distribution to provide a count and distribution of the number of fluorescent emitters within the first fluorescent puncta.10-20-2011
20110257893METHODS FOR CLASSIFYING SAMPLES BASED ON NETWORK MODULARITY - Methods for classifying samples are based on alterations in network modularity. The methods are useful for the diagnosis, prognosis and monitoring of a biological state such as a disease state. In certain embodiments, methods for diagnosing disease or evaluating the prognosis of disease or identification of a disease state are computer-implemented.10-20-2011
20110257892METHODS FOR IDENTIFYING SETS OF OLIGONUCLEOTIDES FOR USE IN AN IN VITRO RECOMBINATION PROCEDURE - In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.10-20-2011
20110257890Method for Differentially Quantifying Naturally Processed HLA-Restricted Peptides for Cancer, Autoimmune and Infectious Diseases Immunotherapy Development - The invention relates to a method for quantitatively identifying relevant HLA-bound peptide antigens from primary tissue specimens on a large scale without labeling approaches. This method can not only be used for the development of peptide vaccines, but is also highly valuable for a molecularly defined immunomonitoring and the identification of new antigens for any immunotherapeutic strategy in which HLA-restricted antigenic determinants function as targets, such as a variety of subunit vaccines or adoptive T-cell transfer approaches in cancer, or infectious and autoimmune diseases.10-20-2011
20110257889SEQUENCE ASSEMBLY AND CONSENSUS SEQUENCE DETERMINATION - Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof. In particularly preferred embodiments, nucleic acid sequences generated by such methods are subjected to de novo assembly and/or consensus sequence determination.10-20-2011
20110257888METHOD OF DETERMINING CHRONIC FATIGUE SYNDROME - The present invention provides a method of determining whether or not a subject is affected with chronic fatigue syndrome (CFS) comprising: measuring, in a biological sample from the subject, an expression level of a transcript of at least one gene respectively from at least two gene groups selected from six specific gene groups; calculating a value representing a deviation of the measured expression level based on an expression level of a transcript of the corresponding gene in a population of healthy subjects; obtaining an average of the value(s) representing a deviation; and determining whether or not the subject is affected with CFS by using the average.10-20-2011
20130158883INTENTION CONVEYANCE SUPPORT DEVICE AND METHOD - According to a conventional BMI technology for controlling external equipment or transmitting an intention to another person by focusing on a biosignal such as brain activity, there has been the problem that a large-sized apparatus is required, the operation method is complex from the user's viewpoint, and noise is large. The present invention provides an apparatus and method such that an intention in the brain can be analyzed with high accuracy and at high speed and transmitted in real-time. A communication assist apparatus according to the present invention comprises an apparatus for presenting a visual stimulus on a display screen and the like, and a processing apparatus for processing brain wave data from an electroencephalograph that measures a brain wave after stimulus presentation by the presenting apparatus. The processing apparatus determines that a specific intention decision has been made in the brain when the product of an accumulated discrimination score according to a discriminant analysis function obtained by analyzing the brain wave data and a success rate exceeds a threshold value, and then outputs a determination result to a device.06-20-2013
20130158881AUTONOMOUS MONITORING METHOD AND SYSTEM USING SENSORS OF DIFFERENT SENSITIVITIES - A method and system of monitoring for chemical or other toxic agents includes operating a plurality of first type sensors having a first level of sensitivity to an agent in a monitored area. Concurrently a second type sensor is operated having a second level of sensitivity to the agent in the monitored area, where the second level of sensitivity is at least ten times more sensitive than the first level of sensitivity. Input from the plurality of first type sensors and the second type sensor is received and analyzed, at a central location, in order to determine the presence of the agent in the monitored area.06-20-2013
20130158880Analysis of Community Structures in Environmental Samples - Systems and methods for analyzing community structures within a plurality of environmental samples are described herein. The method includes obtaining taxa data corresponding to taxonomic groups within the plurality of the environmental samples. Based on the taxa data, an abundance value for each of the taxonomic groups with respect to each of the plurality of environmental samples is determined. Further, based on abundance values, an interaction factor for each pair of the taxonomic groups in the plurality of environmental samples is computed. The interaction factor is indicative of a degree of interaction between a pair of taxonomic groups from among the taxonomic groups. Based in part on interaction factors and abundance values, the plurality of the environmental samples is clustered.06-20-2013
20130158879METHODS AND APPARATUS FOR HARDWARE BASED RADIATION DOSE CALCULATION - Disclosed is an example method to calculate radiation dose. The method includes receiving a tissue matrix in which the tissue matrix includes a plurality of voxels. The example method also includes producing a first plurality of transport lines with a direction controller in which each transport line is indicative of a cone of irradiated energy, and calculating at least one radiation dose with at least one deposit engine substantially in parallel with producing a second plurality of transport lines with the direction controller.06-20-2013
20080319676Absolute Quantitation of Protein Contents Based on Exponentially Modified Protein Abundance Index by Mass Spectrometry - The present inventor has established protein abundance index (PAI, π) to determine the protein contents in a protein mixture solution using nanoLC-MSMS data. Digested peptides were analyzed by nanoLC-MS/MS and the obtained results were applied to a Mascot protein identification algorism based on tandem mass spectra. PAI is defined as the number of observed peptides divided by the number of observable peptides per protein. PAI from different concentrations of serum albumin showed linear relationship to the logarithm of the protein concentration. This was also valid for 47 proteins in a mouse whole cell lysate analyzed by single run of nanoLC-MS/MS. On the other hand, Mascot protein scores as well as the number of identified peptides per protein were less correlated to the protein abundance. For absolute quantitation, PAI was converted to exponentially modified PAI (EMPAI, mπ), which is proportional to protein contents in the protein mixture. For the 47 proteins in the whole lysate, the deviation percentages of the EMPAI-based concentrations to the actual values were within 63% in average. EMPAI was successfully applied to comprehensive protein expression analysis and performed a comparison study between gene and protein expression in an HCT116 human cancer cells. Accordingly, the present invention provides a method and a computer program for quantifying the protein contents based on the protein abundance index.12-25-2008
20080281528System and Method for Environmental Sampling and Diagnostic Evaluation - An environmental sampling system and method that collects biological contaminates in a removable cassette device via a sample capture media, such as a filter. The cassette device which is designed to specifically cause mixing of the air stream in a manner to get even distribution of the airborne particulates on the filter media has affixed thereto a data storage unit for storing other environmental parameters sensed and measured by the system in addition to the IAQ questionnaire information inputted by the investigator. After the sample period is complete, the system can be re-deployed in the field or environment by simply replacing the removable cassette device having the data storage unit. The collected biological contaminates in a removable cassette device and stored data in the affixed data storage unit are sent to a laboratory for analysis. The environmental sampling system may be operated independently of the removable cassette device to obtain and data log physical environmental data such as temperature, relative humidity, wind velocities, pressure differentials, and particulate counts.11-13-2008
20120278000METHOD FOR ASSESSING EFFICACY OF COMBINATION CHEMOTHERAPY, AND PROGRAM AND DEVICE FOR ASSESSING THE SAME - A method for assessing an efficacy of combination chemotherapy, comprising: a first obtaining process for obtaining a specific activity value of Cyclin Dependent Kinase (CDK) 1 and a specific activity value of CDK2 in a biological sample including a carcinoma cell collected from a cancer patient; a second obtaining process for obtaining a GSTπ expression level in the biological sample; and an assessment process for assessing the efficacy of the combination chemotherapy on the cancer patient based on the specific activity values of CDK1 and CDK2 obtained in the first obtaining process and the GSTπ expression level obtained in the second obtaining process.11-01-2012
20080255766Methods and kits for the diagnosis of sickle cell - Provided are methods for the detection and diagnosis of sickle cell. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of sickle cell. At least two new biomarkers for sickle cell are thus disclosed, Eotaxin and Monocyte Chemotactic Protein-1. Altogether the concentrations of eleven analytes provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from sickle cell. Other important biomarkers for sickle cell are described, including but not limited to IL-12p40, SHBG, MMP-9, Adiponectin, Haptoglobin, FGF basic, IgM, Growth Hormone, Factor VII. Kits containing reagents to assist in the analysis of fluid samples are also described.10-16-2008
20080255763SYSTEM AND A METHOD FOR OBSERVING AND PREDICTING A PHYSIOLOGICAL STATE OF AN ANIMAL - A system for observing and predicting a physiological state of an animal has been provided. The system includes a computer including a processor and being operatively connected to a database, at least one sample providing device for repetitively providing at least one sample of a body fluid of the animal, an analysis apparatus for analyzing the at least one sample, so as to obtain at least one sample value of at least one parameter of the body fluid, a data interface for repetitively entering the sample value of the at least one parameter in the database, where the database is adapted to store multiple database entries representing the sample value of the at least one parameter at various points in time, and where the processor is programmed to: perform at least one mathematical analysis of the at least one sample value, and selecting, on the basis of the at least one mathematical analysis, the point in time for providing a subsequent sample and performing a subsequent analysis of the subsequent sample for at least one of the parameters.10-16-2008
20080255764Methods for the Diagnosis of Colorectal Cancer and Ovarian Cancer by the Measurement of Vitamin E-Related Metabolites - The present invention relates to the diagnosis of colorectal and ovarian cancers (CRC and OC, respectively). The present invention describes the relationship between endogenous small molecules and CRC or OC. Specifically, the present invention relates to the diagnosis of CRC and OC through the measurement of vitamin E isoforms and related metabolites. The present invention also relates to diagnostic markers identified in said method. The present invention relates to the underlying case and pre-symptomatic phases of CRC, the diagnosis of various stages and severity of CRC, the early detection of CRC, monitoring and diagnosing the effect of therapy on CRC and OC health states.10-16-2008
20110125408Thermoelectric biosensor for analytes in a gas - A biosensor for detecting at least one analyte in a gas includes a capture apparatus, a thermoelectrical sensor, and a microprocessor attached to the first ends of a first lead and a second lead, the two leads having second ends attached to the two contact pads of a thermopile whose difference is converted to concentration of the analyte and shown on an electronic display. The thermoelectrical sensor has a layer of at least one interactant, at least one thermopile and an insulator. The interactant with the analyte produces or consumes heat which is transferred to the thermopile which develops a voltage difference that causes the microprocessor to convert the voltage an indication of the analyte.05-26-2011
20110004416METHODS AND SYSTEMS FOR CONSERVATIVE EXTRACTION OF OVER-REPRESENTED EXTENSIBLE MOTIFS - Methods and systems of extracting extensible motifs from a sequence include assigning a significance to extensible motifs within the sequence based upon a syntactic and statistical analysis, and identifying extensible motifs having a significance that exceeds a predetermined threshold.01-06-2011
20110004415DIGITAL CELL - It is intended to provide a method and system for carrying out data production with respect to the actual status of cells as a profile. It is also intended to provide a system and method for presenting time-lapse and/or real-time information of cell interior directly, or as it is, from the viewpoint of a complex system. It is further intended to provide a method of presenting a digital cell. Thus, there is provided a method of producing profile data relating to cell information, comprising the step (a) of arranging cells in an immobilized form on a support and the step (b) of monitoring over time biological factors on or inside the cells or an aggregate thereof, thereby producing profile data for the cells. Furthermore, there is provided a method of producing a digital cell, comprising procuring experimental data by the use of the above method.01-06-2011
20110004414Method for Predicting Respiratory Toxicity of Compounds - The invention provides methods for analyzing and predicting the in vivo respiratory toxicity of a compound (e.g., pharmaceutical, biological, cosmetic, or chemical compounds) or composition comprising a combination of an in vitro mammalian cell model with multiple endpoint analysis, and time and concentration response curves. The methods allow the determination of a predicted in vivo respiratory toxicity value of a compound without the use of animals, with a high degree of accuracy. The methods comprise detecting any combination of cell viability markers and expression levels of genes implicated in respiratory toxicity and/or sensitization, such as pro-inflammatory response genes, combining the viability and gene expression level data with concentration response and time response data, conducting a computational analysis, and comparing test compound data to a database of known respiratory toxicants/sensitizers to predict and/or analyze the respiratory toxicity. An indication of organ specificity is provided by a toxicity index, which is determined by comparing mean IC01-06-2011
20110004412CLINICAL APPLICATIONS OF NEUROPSYCHOLOGICAL PATTERN ANALYSIS AND MODELING - A method for functional analysis of neurophysiological data by decomposing neurophysiological data and EEG signal to form a plurality of signal features. The signal features may then optionally be analyzed to determined one or more patterns.01-06-2011
20110004410DEVICE FOR THE COLLECTION AND PROCESSING OF INFORMATION RELATING TO THE EXPOSURE OF ONE OR MORE PERSONS TO ONE OR MORE PRODUCTS OF CHEMICAL OR BIOLOGICAL ORIGIN AND METHOD FOR THE USE OF SUCH A DEVICE - A device for the collection and processing of information relating to the exposure of one or more persons (01-06-2011
20100280762System and Method for Analyzing Biological Samples Using Raman Molecular Imaging - A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression.11-04-2010
20110054799DEVICE FOR DETECTING AND DISPLAYING ONE OR MORE OF BODY WEIGHT, BODY FAT PERCENTAGE, BLOOD PRESSURE, PULSE AND ENVIRONMENTAL TEMPERATURE - A device for measuring and displaying body parameters includes a sensor that generates a signal representing a detected body parameter, such as body fat, body water and weight, of an individual; a transmitter to wirelessly transmit the signal; a receiver to receiver and display the sensed measurements as well as a user's name, time, date and temperature. The invention also pertains a method for determining fitness comprising the steps of: inputting, data pertaining to one of date, time, an individual's name, and fitness statistics, sensing parameters of one or more of an a body fat, a body a water and a weight; recording sensed parameters and said data; and transmitting the sensed parameters and said data; receiving said sensed parameters and said data and a signal proportional to a temperature and displaying one or more of said sensed parameters, data and temperature on a portable display unit.03-03-2011
20110054798FLOW CYTOMETER REMOTE MONITORING SYSTEM - Generally, a computer implemented remote monitoring system which generates a viewable reduced byte data representation for each one of a plurality of analyzed instrument signals. Specifically, a flow cytometer remote monitoring system which generates a viewable reduced byte data representation for each one of a plurality analyzed flow cytometer signals.03-03-2011
20110022324MOLECULAR READER - Systems and methods disclosed include: a support apparatus configured to detachably receive a chip; movable pins extendible from a first position to a second position, where, in the first position, the movable pins do not contact a chip positioned on the support apparatus, and in the second position, the movable pins contact electrical terminals of a heating element within a chip positioned on the support apparatus; a radiation source configured to direct radiation to be incident on a chip positioned on the support apparatus; a detector; and an electronic processor, the electronic processor being configured to detect molecules in a sample positioned within the chip, and to determine a temperature of the chip by measuring an electrical resistance between two of the multiple pins connected to the electrical terminals.01-27-2011
20110257895TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.10-20-2011
20110264378Method, System, and Computer Program Product For Tracking of Blood Glucose Variability in Diabetes - An embodiment may be in the field of glycemic analysis and control. More specifically, an embodiment or approach may provide a novel method, system, and computer program for the visual and quantitative tracking of blood glucose variability in diabetes from self-monitoring blood glucose (SMBG) data and/or continuous glucose monitoring (CGM) data. More particularly, an embodiment or aspects thereof may use glucose measurements obtained from self-monitoring data and/or CGM data of an individual or a group of individuals to track and analyze blood glucose variability.10-27-2011
20110087439SYSTEMS AND METHODS FOR IDENTIFYING MATERIALS UTILIZING MULTIVARIATE ANALYSIS TECHNIQUES - Described are a system and method for identifying a material. A spectrum is received. A barcode is generated from a sign of a second derivative of the spectrum. Multivariate data analysis tools and techniques are applied based on the barcode. The material is identified from results of the multivariate data analysis based on the barcode.04-14-2011
20100292932METHOD AND APPARATUS FOR ESTIMATING FEATURES OF TARGET MATERIALS BY USING KINETIC CHANGE INFORMATION - Disclosed are a method and an apparatus for estimating the features (concentration, weight, volume, etc.) of target materials, by using kinetic change information along time, when measuring the results of a chemical reaction between two materials, target materials and reactant, with an optical or electrochemical method. More precisely, the disclosed method and apparatus obtain in advance the correlation between accurate feature values of the target materials measured by a reference equipment and the kinetic change information related to the feature values of the target materials which is varying along the passage of time and indicates the results of chemical reaction measured by an optical or electrochemical method, and then estimates the feature values of the new samples using the correlation and the kinetic change information obtained from the new sample. In addition, the invention relates to a method and an apparatus for correcting errors by using kinetic change information of target materials, more particularly to a method and an apparatus for correcting the feature values of the first material by using the kinetic change information for the features (concentration, amount, etc.) of the first material, a correlation between the kinetic change information and the features of the second material, and a correlation between measurement errors of the features of the second material and the features of the first material.11-18-2010
20100292929SYSTEMS AND METHODS FOR GENERATING FEASIBLE SOLUTIONS FROM TWO PARENTS FOR AN EVOLUTIONARY PROCESS - Systems and methods may include receiving a pair of parent chromosome data structures, where each parent chromosome data structure provides a plurality of genes representative of variables that are permitted to evolve; combining genes of the two parent chromosome data structures to generate at least one first child chromosome data structure; evaluating the at least one first child chromosome data structures according to a plurality of constraint functions to generate a respective plurality of constraint function values for each of the at least one first child chromosome data structure, where the constraint functions define constraints on a feasible solution set; determining whether any of the at least one first child chromosome data structure is within the feasible solution set.11-18-2010
20100292930METHODS FOR GENERATING DATABASES AND DATABASES FOR IDENTIFYING POLYMORPHIC GENETIC MARKERS - Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.11-18-2010
20100292928SYSTEMS AND METHODS FOR GENERATING RANDOM FEASIBLE SOLUTIONS FOR AN EVOLUTIONARY PROCESS - Systems and methods may include identifying an input population of parent chromosome data structures, where each parent chromosome data structure provides a plurality of genes representative of variables in which associated values are permitted to evolve; selecting pairs of parent chromosome data structures from the input population of parent chromosome data structures; combining genes of each selected pair of parent chromosome data structures according to at least one evolutionary operator to generate a plurality of child chromosome data structures; evaluating the plurality of child chromosome data structures according to a plurality of constraint functions to generate a respective plurality of constraint function values for each child chromosome data structure, where the constraint functions define constraints on a feasible solution set; determining whether any of the plurality of child chromosome data structures are within the feasible solution set based upon the respective plurality of constraint violation function values.11-18-2010
20110125409MEASURING AND ANALYZING MULTI-DIMENSIONAL SENSORY INFORMATION FOR IDENTIFICATION PURPOSES - Methods and systems are provides for measuring multi-dimensional sensing information for identification purposes. The identity of one or more substances is determined through analysis of multidimensional data that can include, among others, intrinsic information as well as extrinsic information. The method for identification of a substance comprises utilizing pattern recognition to form descriptors to identify characteristics of the substance. A system and computer program for performing analysis of the multidimensional data are also described.05-26-2011
20100312482FRET DETECTION METHOD AND DEVICE - When FRET efficiency is measured quantitatively by removing uncertain elements of fluorescence detection information, calibration information prestored in a storage means while including at least the leak rate of donor fluorescence component emitted from a donor molecule, the leak rate of acceptor fluorescence component emitted from an acceptor molecule, and the non-FRET fluorescence lifetime of the donor fluorescence component when FRET is not generated out of the fluorescence of a measurement object sample is acquired. The FRET fluorescence lifetime of the donor fluorescence component is then determined using the intensity information and phase information of fluorescence of the measurement object sample, the leak rate of donor fluorescence component and the leak rate of acceptor fluorescence component, thus determining the FRET fluorescence efficiency.12-09-2010
20100324830HANDHELD OPTICAL SENSOR FOR MEASURING THE NORMALIZED DIFFERENCE VEGETATIVE INDEX IN PLANTS - A handheld sensor is disclosed. The sensor has a microcontroller, a current pulse control unit coupled to a light emitting diode (LED), and a photodiode. The microcontroller controls the current pulse control unit to provide a pulsed illumination of a target plant and the photodiode reads the magnitude of the reflectance from the target plant. The microcontroller accepts the reading from the photodiode and computes a normalized difference vegetative index (NDVI) based at least on the reading.12-23-2010
20100324827Fluid Responsiveness Measure - A method and system for measuring fluid responsiveness of a patient is disclosed. Information related to fluid responsiveness of a patient may be derived from a PPG signal, for example, by analyzing the PPG signal transformed by a continuous wavelet transform. Other techniques for deriving information related to fluid responsiveness of a patient include, for example, analyzing the amplitude modulation, frequency modulation, and/or baseline changes of a PPG signal.12-23-2010
20110087438COMPUTER THAT WEIGHS - A system and method of using an adaptable interface for a medical device such as a scale. The scale includes a memory, a display, a processor, and a measurement component to measure one or more characteristics of a subject, such as height or weight. The adaptable interface includes a reconfigurable driver module that enables communication with different Electronic Health Record (“EHR”) systems. The interface can download new drivers or update drivers to reconfigure the driver module. The reconfigured driver module is then configured to communicate with an EHR system according to the particular EHR system communication protocol. The adaptable interface is modular and includes one or more mounting adapters to enable coupling to adjustable interface mounting assembly. The adjustable interface mounting assembly is also operable to receive other modular interface units.04-14-2011
20100332144ANALYSIS APPARATUS AND MEASUREMENT UNIT - This analysis apparatus includes a plurality of a plurality of measurement units of mutually identical types generating measurement data by measuring the specimens, a transporter transporting the specimens to the respective ones of the plurality of measurement units, a display, common to the plurality of measurement units, displaying the analytical results generated by analyzing the measurement data and a transmitter transmitting the analytical results to a host computer.12-30-2010
20100179768Method, System and Computer Simulation Environment for Testing of Monitoring and Control Strategies in Diabetes - A simulation environment for in silico testing of monitoring methods, open-loop and closed-loop treatment strategies in type 1 diabetes. Some exemplary principal components of the simulation environment comprise, but not limited thereto, the following: 1) a “population” of in silico “subjects” with type 1 diabetes in three age groups; 2) a simulator of CGM sensor errors; 3) a simulator of insulin pumps and discrete insulin delivery; 4) an interface allowing the input of user-specified treatment scenarios; and 5) a set of standardized outcome measures and graphs evaluating the quality of the tested treatment strategies. These components can be used separately or in combination for the preclinical evaluation of open-loop or closed-loop control treatments of diabetes.07-15-2010
20100179767PORTABLE PLANT HEIGHT AND EAR HEIGHT MEASURING DEVICE - A method and apparatus for dimensionally characterizing a target structure. In an example of the apparatus, the apparatus has a pole having a bottom end and a top end, an indicator system adapted to apprise an operator of the position of a dimension determination system relative to the target structure, and a measurement system adapted to apprise the operator of a dimension of one or more features of the target structure. In another example, the method includes taking a pole having a bottom and top end with a height determination system, a height indicator system and a height measurement system, orienting the pole relative to the plant structure, raising the height determination system to the height of the target plant structure, and determining the height of the target plant structure.07-15-2010
20100179764METHOD, APPARATUS, AND PROGRAM FOR EVALUATING DRIVABILITY OF A VEHICLE - A time series myoelectric potential signal is acquired, which is representative of time series activity amount of a muscle of a driver when the driver is performing a driving operation on the vehicle, the muscle being involved in the driving operation. Based on the acquired time series myoelectric potential signal, a parameter value indicative of a fluctuation amount of the time-series myoelectric potential signal and an average value of the myoelectric potential signal are obtained. Drivability of the vehicle is evaluated based on the obtained parameter value and the obtained average value.07-15-2010
20110257891THERAPY PREDICTION AND OPTIMIZATION FOR RENAL FAILURE BLOOD THERAPY, ESPECIALLY HOME HEMODIALYSIS - A method of predicting serum phosphorus concentrations in a patient during hemodialysis includes measuring serum phosphorus concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a phosphorous mobilization clearance and a pre-dialysis distribution volume of phosphorus for the patient. Serum phosphorus concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated phosphorous mobilization clearance and pre-dialysis distribution volume of phosphorus of the patient.10-20-2011
20090171592Homology Models of Mammalian Zinc Transporters and Methods of Using Same - The present invention is a method of identifying a compound that has a sufficient level of binding with a target site on a mammalian zinc transporter, or a portion thereof. The method comprises (a) providing a homology model of a mammalian zinc transporter, or portion thereof, comprising at least one target site; and (b) employing computational means to evaluate the level of binding of the compound with the target site, or a portion thereof. If a sufficient level of binding is found, then a compound is identified.07-02-2009
20090171590System and Methods for Sample Analysis - The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.07-02-2009
20090171589Method, System and Computer Program Product for Evaluation of Blood Glucose Variability In Diabetes From Self-Monitoring Data - A system, computer program product, method and algorithm for evaluation of blood glucose variability—one of the most important parameters of diabetes management. An embodiment of the method may use routine self-monitoring blood glucose (SMBG) data collected over a period of 2-6 weeks, for example, based on a theory of risk analysis of blood glucose data. One aspect may include a method, system and computer program product for computing the Average Daily Risk Range (ADRR)—a measure of overall glucose variability. Another aspect may include a method, system, and computer program product for estimating separately the glucose variability in the hypoglycemic range via a Low BG Index (LBGI) and the glucose variability in the high BG range via High BG Index (HBGI) followed by a combination of the two indices into a single variability display.07-02-2009
20090171591Methods for classification of somatic embryos comprising hyperspectral line imaging - The present invention relates to methods, apparatus, and imaging systems for using near-infrared spectroscopy imaging of plant embryos for classifying plant embryos. In one embodiment, a method is provided for classifying a plant embryo of an unknown type based on near infrared spectroscopy imaging.07-02-2009
20090204336PDZ-Domain Modulators - The invention relates to compounds which bind to the PDZ domains of proteins with PDZ domains, the uses of such compounds and screening methods for identification of such compounds.08-13-2009
20110137570METHODS FOR STRUCTURAL ANALYSIS OF GLYCANS - The invention relates to methods useful for the structural analysis of glycans. Methods are disclosed for sequencing glycans using stepwise disassembly processes by analysis of the fragments produced therein. Methods are additionally provided for identifying MS06-09-2011
20120310540SYSTEMS AND METHODS FOR ESTIMATING PHOTOSYNTHETIC CARBON ASSIMLATION - Methods, devices, and systems for measuring carbon assimilation based on simultaneous or near-simultaneous measurements of chlorophyll fluorescence and stomatal conductance of plant. A sample containing chlorophyll, such as a plant leaf, is illuminated with light, e.g., in the form of a single saturating pulse or multiple pulses, and chlorophyll fluorescence and stomatal conductance of the chlorophyll sample are measured. A porometer or infra-red gas analyzer is used to measure stomatal conductance and a photodetector is used to measure fluorescence. A carbon assimilation value for the chlorophyll sample is determined using the measured chlorophyll fluorescence and the measured stomatal conductance.12-06-2012
20120310538System and Method for Diagnosing a Biological Sample - The present disclosure provides for a system and method for analyzing biological samples to thereby provide a diagnosis. A system may comprise an illumination source, a filter and a detector configured to generate at least one of: a visible data set representative of a biological sample, a SWIR data set representative of a biological sample, and combinations thereof. A method may comprise illuminating a biological sample to generate a plurality of photons, filtering a said plurality of interacted photons, detecting12-06-2012
20120310537IDENTIFICATION OF ABERRANT MICROARRAY FEATURES - Described herein is a method for identifying an aberrant feature on a nucleic acid array. In general terms, the method comprises: a) obtaining a log transformed normalized value indicating the amount of hybridization of a test sample to a first feature on the nucleic acid array; b) calculating a z-score for the first feature using: the log transformed normalized value; and the distribution of reference log transformed normalized values that indicate the amount of hybridization of control samples to the same feature on a plurality of reference arrays; and c) identifying said test feature as aberrant if it has a z-score that is above or below a defined threshold.12-06-2012
20110098934Method and Apparatus for Measuring Data for Injury Analysis - An apparatus as provided for measuring acceleration of a person's head or other object. The apparatus comprises a sensor for sensing acceleration and a controller for controlling recording of data resulting from the sensed acceleration due to an explosive force. The controller is adapted to determine whether or not to enable recording of the data based on the sensed acceleration. A data receiver is provided to receive the sensed acceleration data from the sensing means, and requires electrical power to enable data to be received thereby. The controller controls electrical power to the receiver so that if the sensed acceleration reaches or exceeds a predetermined value, electrical power to the data receiver is enabled. The recorded acceleration data may be used for injury analysis.04-28-2011
20100228494Postural information system and method including determining subject advisory information based on prior determined subject advisory information - A method includes, but is not limited to: for each of one or more first instances, determining subject advisory information regarding one or more subjects associated with the first instance based at least in part upon postural influencer status information including information involving one or more spatial aspects for each of two or more postural influencers of the one or more subjects, and for a second instance, based at least in part upon each of the subject advisory information associated with each of the one or more first instances, generating subject advisory information regarding one or more subjects being associated with the second instance and being posturally influenced by two or more postural influencers. In addition to the foregoing, other related method/system aspects are described in the claims, drawings, and text forming a part of the present disclosure.09-09-2010
20100217534METHODS AND MATERIALS FOR CANINE BREED IDENTIFICATION - In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations.08-26-2010
20100153019LEAST-SQUARE DECONVOLUTION (LSD): A METHOD TO RESOLVE DNA MIXTURES - Least Square Deconvolution (LSD) uses quantitative allele peak data derived obtained from a sample containing the DNA of more than one contributor to resolve the best-fit genotype profile of each contributor. The resolution is based on finding the least square fit of the mass ratio coefficients at each locus to come closest to the quantitative allele peak data. Consistent top-ranked mass ratio combinations from each locus can be pooled to form at least one composite DNA profile at a subset of the available loci. The top-ranked DNA profiles can be used to check against the profile of a suspect or be used to search for a matching profile in a DNA database.06-17-2010
20100153016Diagnostic system for selecting nutrition and pharmacological products for animals - An analysis of the profile of a non-human animal comprises: a) providing a genotypic database to the species of the non-human animal subject or a selected group of the species; b) obtaining animal data; c) correlating the database of a) with the data of b) to determine a relationship between the database of a) and the data of b); c) determining the profile of the animal based on the correlating step; and d) determining a genetic profile based on the molecular dietary signature, the molecular dietary signature being a variation of expression of a set of genes which may differ for the genotype of each animal or a group of animals Nutrition and pharmalogical assessments are made. Reporting the determination is by the Intemet, and payment for the report is obtained through the Internet.06-17-2010
20100082261Genetic Diagnosis Using Multiple Sequence Variant Analysis - The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention is useful to define the subset of variations that are most suited as genetic markers to search for correlations with certain phenotypic traits. Additionally, the insights are useful for the development of algorithms and computer programs that convert genotype data into the constituent haplotypes that are laborious and costly to derive in an experimental way. The invention is useful in areas such as (i) genome-wide association studies, (ii) clinical in vitro diagnosis, (iii) plant and animal breeding, (iv) the identification of micro-organisms.04-01-2010
20100063747Using Plasma Proteomic Pattern For Diagnosis, Classification, Prediction of Response to Therapy and Clinical Behavior, Stratification of Therapy, and Monitoring Disease in Hematologic Malignancies - The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra from the plasma samples with or without fractionation; comparing the protein spectra with clinical data; and identifying protein markers in the plasma samples that correlate with the clinical data. Protein markers identified by this approach can then be used to create a protein profile that can be used to diagnose the hematologic malignancy or determine the prognosis of the hematologic malignancy. Potentially these specific proteins can be identified and targeted in the therapy of these malignancies.03-11-2010
20100063745METHOD OF ESTIMATING SECONDARY STRUCTURE IN RNA AND PROGRAM AND APPARATUS THEREFOR - Assuming frame F having specific short length L03-11-2010
20090299643Computational Analysis Of The Synergy Among Multiple Interacting Factors - Systems and methods for selecting factors from a data set of measurements are provided. The measurements include values of factors and/or outcomes. Two or more factors that are jointly associated with one or more outcomes from the data set are identified. Each of the two or more factors are analyzed to determine at least one cooperative interaction among the factors with respect to an outcome. The two or more factors can be a module of factors.12-03-2009
20090299641METHODS AND APPLICATIONS FOR TARGET QUANTIFICATION - The present invention provides methods and software applications for quantifying a target in an experimental sample by collecting and processing initial signal data from the experimental sample and at least two standard control samples containing known target copy numbers. In this regards, the present invention allows the quantification of target copy number in the experimental sample.12-03-2009
20090299647METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR IDENTIFYING BINDING CONFORMATIONS OF CHEMICAL FRAGMENTS AND BIOLOGICAL MOLECULES - A new approach to identifying binding conformations of chemical fragments and biological molecules is presented, in which fragment poses are explored in a systematic fashion. In an embodiment, for each pose, a fast computation is performed of the fragment interaction with the biological molecule using interpolation on a grid. Once the energies of fragment poses are computed, thermodynamical quantities such as binding affinity, binding enthalpy, and binding entropy are computed by direct sum over fragment poses. Using the present invention, it is possible to navigate fragment configuration space to identify separate binding modes. The present invention can be used to scan an entire biological molecule to identify possible binding pockets, or it can be used for localized explorations limited to interesting areas of known binding pockets.12-03-2009
20090292477Method and Apparatus for Screening and Assaying Environmental Sample - A screening measurement technology enabling a prompt determination about whether or not further confirmation is required by another measuring method, for an environmental sample, such as a sample containing dioxins, is provided. A sample solution in which a known amount of antibodies are mixed, is poured into a measurement cell (11-26-2009
20090292478System and Method for Analysis of Multiple Diseases and Severities - A data processing technique is provided. In one embodiment, a computer-implemented method includes accessing reference deviation maps for a plurality of disease types. The reference deviation maps may include subsets of maps associated with severity levels of respective disease types, and a disease severity score may be associated with each severity level. The method may include selecting patient severity levels for multiple disease types based on the subsets of reference deviation maps. Also, the method may include automatically calculating a combined patient disease severity score based at least in part on the disease severity scores associated with the selected patient severity levels, and may include outputting a report based at least in part on the combined patient disease severity score. Additional methods, systems, and manufactures are also disclosed.11-26-2009
20090210163System And Method For Evaluating Physiological Parameter Data - Embodiments disclosed herein may include systems and methods for evaluating physiological parameter data. Embodiments of methods may include monitoring a patient to produce a signal comprising a sequence of numerical values for a physiological parameter over a time period, calculating an index from the signal, comparing the index to a reported index, and if the index is greater than the reported index, setting the reported index to the value of the index. Embodiments of methods may include calculating a modulation of the signal, comparing the modulation to a previous value of the modulation to identify a trend in the modulation and if the trend corresponds to an undesirable condition, using a first function to increase the reported index. Embodiments of methods may include providing an indication of a physiological status based on the reported index.08-20-2009
20120150450BIOMETRIC AUTHENTICATION SYSTEM, METHOD, AND PROGRAM - Provided are a biometric authentication system which can guarantee an FMR in a practical processing time even when an attacker attacks the biometric authentication system by selectively using query data in which data of a set other than a biometric information data set is included, a biometric authentication method, and a biometric authentication program.06-14-2012
20110137571METER HAVING MULTI-LEVEL USER INTERFACE - A meter adapted to determine and store an analyte concentration reading, in particular a glucose concentration reading, and including an interface having a plurality of predefined levels of user features. The predefined levels may be selected by a user based on the user's preferences, needs and abilities.06-09-2011
20110264377METHOD AND SYSTEM FOR ANALYSING DATA SEQUENCES - A sequencing system and method of generating index keys for one or more data sequence based on masked values of reads from a sample data sequence and/or one or more template data sequence. Each index key value may be based upon a concatenated form of each extracted value, although other transformations may be employed. A number of different masks may be applied to the data sequence at a number of locations. At least some of the masks may include indels and/or substitutions. The masks may be manually or computer generated. The data sequence may be one or more reference templates and/or one or more sample sequences, such as DNA or RNA sequences. Sample data may be stored in the one or more index by correlating masked values of reads with index key values and storing an identifier for each read in association with a corresponding index key value. Sample data sequences may be evaluated by comparing sample sequence and template sequences having the same index key value and determining scores for the reads based on the comparison and associating the scores with the reads. Reads may be rejected based upon the comparison. A read may be rejected if there is more than one position at which it has a best score. A read may be rejected if its score falls below a threshold score level.10-27-2011
20110264376EVALUATING GENETIC DISORDERS - The present invention relates to genetic analysis and evaluation utilizing copy-number variants or polymorphisms. The methods utilize array comparative genomic hybridization and PCR assays to identify the significance of copy number variations in a subject or subject group.10-27-2011
20100063741CALCULATING SAMPLE SIZE FOR CLINICAL TRIAL - A method for calculating a sample size for a clinical trial of a first treatment can be provided. The method can include reading a survival curve from a clinical trial for a second treatment, wherein the clinical trial may be selected by a user interacting with a user interface. The method can further include selecting a plurality of points on the survival curve and storing coordinates for each of the plurality of points, wherein the plurality of points are selected so as to capture substantial features of the survival curve. Then, a hazard curve is generated based on the coordinates that were stored, wherein the hazard curve may be a step function. The method can further include calculating a sample size for the clinical trial of the first treatment using a Markov model based on the hazard curve.03-11-2010
20100030483ASSESSMENT METHOD TO PROCESS A GLUCOSE CONCENTRATION SIGNAL AND DEVICES THEREOF - Embodiments of an assessment method for processing a signal corresponding to a glucose concentration and performing a retrospective analysis comprises the steps of: a) initiating a first trigger, wherein the first trigger defines the beginning of a segment of a continuous measurement of glucose concentration or defines the first of a series of spot measurements of glucose concentration; b) collecting data of the continuous measurement or the series of spot measurements of glucose concentration to be analyzed, wherein the collected data relates to a glucose concentration excursion corresponding to a reaction to a relevant event such as a meal or physical activity; c) analyzing the collected data initiated by a second trigger, wherein the second trigger defines the end of the collected data to be analyzed, wherein a measure for a grading of the excursion is determined from the collected data, and d) displaying the results of the analysis.02-04-2010
20100030484SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR - Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.02-04-2010
20100030480DEVICE AND METHOD FOR EXAMINATION AND EVALUATION OF A BIOLOGICAL ACTIVE AND/OR BIOLOGICAL ACTIVATABLE SUBSTANCE - The invention relates to a device and method for optical examination and for evaluation of a biological active and/or biological activatable substance (02-04-2010
20100030481Dating hemorrhage - Systems and techniques for dating hemorrhage. In one aspect, a method includes receiving one or more hemorrhage samples that provide information relevant to dating of a hemorrhage, receiving timing information describing timing of the hemorrhage, staining the hemorrhage samples with two or more stains, quantifying two or more parameters that quantitatively characterize two or more properties of the hemorrhage samples on the basis of the staining by the two or more stains, and forming a hemorrhage database that includes the timing information in association with the staining parameters.02-04-2010
20130013213METHODS AND APPARATUS FOR IDENTIFICATION OF DISEASE ASSOCIATED MUTATIONS - In some embodiments, a non-transitory processor-readable medium includes code to cause a processor to receive a set of variants identified by a comparison of a test DNA sequence with a reference DNA sequence and associate at least one of the set of variants with at least one of a set of annotations each indicative of at least one criterion. The code includes code to cause the processor to filter, based on the set of annotations, the set of variants to identify a subset of variants from the set of variants. Each variant from the subset of variants is associated with at least one common annotation from the set of annotations. The code further includes code to cause the processor to present the subset of variants such that the subset of variants can be used to render a clinical diagnosis.01-10-2013
20100023271Data input support system for gene analysis - A data input support system is provided to preliminarily remove particular error causes when genotype data are input for a program to execute linkage disequilibrium analysis or the like. By taking advantage of limiting conditions characteristic of genotype input data and the statistical properties of the entire data set, possible errors are detected by a preprocessing program, the detected errors are associated with false descriptions causing them to report the results, user input responding to the reported results is accepted, and a modified version of the input data is output.01-28-2010
20100023272Expression Data Analysis Systems and Methods - Methods and applications of Global Patter Recognition (GPR), including a system for analyzing the results of real-time polymerase chain reaction (RT-PCR) experiments employing micro-titer and/or microarray plates and robotic plate readers is described. The system employs a set of self-normalizing housekeeping primers or oligonucleotides on the plates/arrays and an algorithmic approach to normalizing expression data from all primers on the plate based on the reaction products of several of the self-normalizing gene primers oligonucleotides. Normalization is accomplished using simplex reactions involving these self-normalizing primers/oligonucleotides; the normalization parameters are then useable across all control and experimental reactions of the plate/array. A ranked list of genes whose amount of change is statistically significant can be determined. The accuracy of this list is enhanced by the data normalization aspect of the system. Other applications of GPR are also disclosed herein.01-28-2010
20100023270Electrodes With Multilayer Membranes And Methods Of Making The Electrodes - A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes at least one layer of a polyanionic or polycationic material. The assembled layers of the membrane are typically disposed in an alternating manner. The sensor also optionally includes a biocompatible membrane.01-28-2010
20100017147Amino-acid biosensor, Fischer-ratio biosensor and health information management system - Disclosed is a biosensor capable of measuring a total concentration of plural types of amino acids. An amino-acid biosensor (01-21-2010
20100017144Lung cancer evaluating apparatus, method, system, and program and recording medium therefor - According to the method of evaluating lung cancer, amino acid concentration data on the concentration value of amino acid in blood collected from a subject to be evaluated is measured, and a lung cancer state in the subject is evaluated based on the concentration value of at least one of Orn, Lys, ABA, Arg, Glu, His, Tau, Pro, Ala, Cit and Ile contained in the measured amino acid concentration data of the subject.01-21-2010
20100017142Low Perfusion Signal Processing Systems And Methods - In some embodiments, systems and methods for identifying a low perfusion condition are provided by transforming a signal using a wavelet transform to generate a scalogram. A pulse band and adjacent marker regions in the scalogram are identified. Characteristics of the marker regions are used to detect the existence of a lower perfusion condition. If such a condition is detected, an event may be triggered, such as an alert or notification.01-21-2010
20090210164ANALYTE MONITORING DEVICE AND METHODS OF USE - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.08-20-2009
20090299648Hydropathy Plots and Fourier Analysis with Ellipsoidal Distance Metric - Techniques for protein structure analysis are provided. In one aspect, an apparatus for characterizing at least a portion of a protein structure comprising amino acid residues is provided. A set of values characterizing the protein structure are determined, wherein each value represents a distance from a center of the protein structure to a center of a given one or more of the amino acid residues. One or more other sets of values characterizing the hydrophobicity of the protein structure are obtained. A Fourier transform is performed on each of the sets of values to obtain transformed values sets. The transformed value sets are compared to correlate the hydrophobicity with the protein structure.12-03-2009
20090138204Single nucleotide polymorphisms sensitively predicting adverse drug reactions (ADR) and drug efficacy - Provided are diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Also provided are polymorphic sequences and other genes and isolated polynucleotides encoding a phenotype associated (PA) gene polypeptide useful in methods to identify therapeutic agents and useful for preparation of a medicament to treat cardiovascular disease or influence drug response.05-28-2009
20090248315System and Method for Determining Clinical Equivalence of Test Methods - A system, method and computer readable medium of instructions are provided which are useful for determining whether an evaluation testing method or device is clinically equivalent to a reference testing method or device. The report can include a modified mean difference plot, a variability chart, confidence intervals for bias and a plot of the intervals. A graphical user interface is provided to allow data associated with the reference and evaluation methods or devices to be identified. A level of variance in the reference method is determined. An observed bias between the evaluation methods or devices and the reference methods or devices is calculated. A confidence interval for the bias is calculated. The biases between the evaluation methods or devices and reference method or device is compared relative to the level of variance in the reference method, and a report is generated including a conclusion about whether the evaluation methods or devices are clinically equivalent to the reference method or device.10-01-2009
20090125242Tomographic phase microscopy - The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.05-14-2009
20110040487SUBSTANCE MONITORING AND CONTROL IN HUMAN OR ANIMAL BODIES - Apparatus for monitoring a substance in human or animal in real time, the apparatus comprising a sensor providing a time series of measurements of substance level, said measurements being indicative of an inferred level of said substance in a part of said human or animal and a processor which applies an interacting multiple model strategy to a system model to provide a combined estimate of the inferred substance level from the substance level measurements. The substance may be glucose. The apparatus may also be adapted to control said substance using said interacting multiple model strategy to a system model to provide a combined estimate of a dose to be applied.02-17-2011
20080215248Method and Device for the Measurement and Identification of Biofilms and Other Deposits Using Vibration - The present invention concerns a method and device to monitor the formation and removal of biofilms and other deposits in ducts, reservoirs and equipments, using vibration. The afore mentioned device is composed by an element that generates vibration (09-04-2008
20090299645Genetic analysis - The present invention provides methods for generating genetic profiles or analyses. Included are methods for conducting comprehensive, dynamic genetic analysis. Also provided are methods for determining genetic health scores for specific phenotypes, such as diseases, disorders, traits, and conditions, as well as for organ systems, for certain medical specialties, and for overall health.12-03-2009
20080255765MONITORING CYCLOSPORINE IN SALIVA - Saliva offers an alternative specimen for the therapeutic monitoring of cyclosporine (CsA) in children and patients with difficult venous access. For a highly protein-bound drug such as CsA, saliva provides a practical approach for measuring the unbound concentration. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is ideally suited for the measurement of drugs in saliva. A solid-phase extraction technique, analytic liquid chromatography over an Aqua Perfect column, maintained at 65° C., and electrospray tandem mass spectrometry were used to quantify CsA in saliva. The method used cyclosporine C (CsC) as the internal standard. Mobile phase comprised of a 97:3 voL mixture of methanol and 30 mmol/L ammonium acetate at a flow rate of 0.5 mL/min. Chromatograms using mass transitions of m/z 1219.9→m/z 1202.9 for CsA and m/z 1235.9→m/z 1218.9 for CsC were obtained. The calibration curve was linear from 1 to 300 μg/L with correlation coefficient values ranging from 0.9732 to 0.9968). The lower limit of quantification was 1 μg/L and limit of detection was 0.6 μg/L with an average extraction recovery of 84.7±2.6% for CsA and 93.7±4.4% for CsC from the saliva matrix. The accuracy of the method ranged from 92% to 104.7%, and the intra- and interim coefficients of variation were 6.9-12.2% and 8.3-12.1%, respectively. The correlation coefficient value between the CsA concentration measurements in 15 paired blood-saliva samples from kidney transplant recipients was 0.695 (P=0.006). The noninvasive and simple method of saliva collection coupled with the LC-MS/MS quantification technique for CsA analysis would generate novel data that could benefit patients undergoing CsA therapy.10-16-2008
20090265116PREDICTION OF AN INDIVIDUAL'S RISK OF DEVELOPING RHEUMATOID ARTHRITIS - Methods for predicting the likelihood of development of rheumatoid arthritis for individuals that present with recent-onset undifferentiated arthritis. The methods are based on the determination of a set of clinical markers and/or parameters and determining a predicted risk for developing rheumatoid arthritis. Clinical markers and parameters that are decisive for the risk for developing rheumatoid arthritis may include serum levels of C-reactive protein, Rheumatoid factors, anti-CCP antibodies, anti-MCV as well as age, gender, localization of the joint complaints, length of morning stiffness, and number of tender and/or swollen joints or combinations thereof. The method may be performed by a computer. The invention further relates to a computer, a sample analyser and a computer program product for performing the method and a data carrier with the computer program product.10-22-2009
20090198451Integrated Biosensor and Simulation System for Diagnosis and Therapy - BioMEMS/NEMS appliance biologically monitors an individual, using biosensors to detect cellular components. Data is simulated or analyzed using systems-biology software, which provides diagnostic or therapeutic guidance.08-06-2009
20110046891CO-CRYSTALLIZATION OF ERR-alpha WITH A LIGAND THAT FORMS A REVERSIBLE COVALENT BOND - The crystal structure of the ligand binding domain of ERR-α in complex with a ligand that forms a reversible thioether bond to Cys325 of ERR-α, methods to measure dissociation rates for ligands that form reversible covalent bonds, and methods to design ligands that form reversible covalent bonds for use as modulators of ERR-α activity are disclosed. The crystal structure and methods provide a novel molecular mechanism for modulation of the activity of ERR-α and provide the basis for rational drug design to obtain potent specific ligands for use as modulators of the activity of this new drug target.02-24-2011
20090319191METHOD FOR DIAGNOSIS OF AN INFECTIOUS DISEASE STAGE AND DETERMINATION OF TREATMENT - The present invention relates to a means for determining if mammals within a group of mammals is affected by an infection that induces or could induce inflammation, if the mammal is likely to recover or not and if infected whether the mammal should be treated or let to recover untreated. By differentiating infected mammals in a group into different subsets representing differing stages of the progress of the disease the present invention teaches how to prognosticate with continuous data the outcome of a treatment/no treatment decision.12-24-2009
20080288174Method for Identifying the Function of a Gene - Described is a method for determining the function of a gene. This method involves determining the amount of transcript for each of a set of candidate genes in samples taken from different phenotypic and/or genotypic states of an organism and determining the amount of each of a plurality of metabolites in different samples taken from the same states as those mentioned above. Subsequently, the data obtained is analyzed by suitable mathematical methods in order to identify a transcript and metabolites which correlate in the different states, thereby identifying a transcript corresponding to a gene which influences the amount of metabolites in the organism. Furthermore described is a method for identifying a gene which is capable of modifying the amount of a metabolite in an organism and to a method for identifying a metabolite which is capable of modifying the amount of a transcript in an organism. Likewise, uses of the genes and metabolites identified in the aforementioned methods are described.11-20-2008
20130184999SYSTEMS AND METHODS FOR CANCER-SPECIFIC DRUG TARGETS AND BIOMARKERS DISCOVERY - The present invention provides users with cloud-based high throughput computing system for integrative analyses of next generation sequencing genomic data, such that human cancer biomarkers and drug targets can be accurately and quickly identified. Advantageously, the present invention harness a comprehensive systematic analysis pipelines for all types of next generation sequencing genomic data, advanced genomic variants calling algorithms and modeling, variant data correlation and integration, and identification of cancer specific biomarkers and therapeutic targets. Thus, the present invention will aid users so that less of their time and efforts are required in order to obtain precisely the desired information for which they are analyzing.07-18-2013
20110307183METHOD FOR THE BACTERIOLOGICAL INVESTIGATION OF A BIOLOGICAL SAMPLE AND RELATIVE DEVICE - A method for the bacterial investigation of a biological sample, which provides to carry out a light scattering reading in order to determine the turbidity according to the McFarland standard of a suspension formed from a liquid culture means or eugonic medium in which the biological sample is inoculated, and in which the turbidity is continuously measured directly from the suspension of the sample analyzed during the growth step of the bacteria, until a determined threshold of turbidity is reached expressed according to the McFarland standard.12-15-2011
20110307180SYSTEM AND METHOD FOR ANALYZING METABOLOMIC DATA - The present invention generates a visual display of metabolomic data compiled by a database and associated processor. More particularly, the present invention provides a database for automatically receiving a three-dimensional spectrometry data set for a group of samples. The present invention also provides a processor device for manipulating the data sets to produce plots that are directly comparable to a plurality of characteristic plots corresponding to a plurality of selected metabolites. Furthermore, the processor device may generate a visual display indicating the presence of the selected metabolites across the group of samples. Thus, the present invention enables a user to analyze a series of complex data sets in a visual display that may indicate the presence of the selected metabolites across the group of samples. Furthermore, the visual display generated by embodiments of the present invention also expedites the subjective analysis of the spectrometry data sets.12-15-2011
20090299644SYSTEM AND METHOD FOR SELECTING SAMPLES FROM AN ANTIBODY ANALYSIS FOR DISPLAY OF COMPLETE SPECIFICITY ANALYSIS DATA - A system and method provides for selecting one or more samples from an antibody specificity analysis for displaying complete antibody specificity analysis data. A plurality of sample sera are run through a protein panel for antibody analysis and a specificity analysis is completed. A positive or negative screening result is displayed for each sample within the panel, and for each positive sample, preliminary diagnostic data such as the PRA value and intensity value are provided. The preliminary diagnostic data is then reviewed by a user to determine whether complete specificity data of each positive sample is needed. In one embodiment, the complete specificity data is available for purchase on a sample-by-sample basis so that if only a small amount of samples are deemed useful, purchase of the complete specificity data for an entire panel of samples is avoided. The specificity data is encrypted until the user decides to purchase it.12-03-2009
20110307181ULTRASONIC APPARATUS - An ultrasonic apparatus is provided with an adaptive signal processing block (12-15-2011
20110307182COMPUTER SYSTEM AND MICROFLUIDIC INSTRUMENTATION FOR NEXT-GENERATION BIOLOGICAL SIGNALING NETWORK RESEARCH AND APPLICATIONS - A computer-controlled micro-instrumentation biochemical reaction environment system includes an electrically-controllable microfludic routing system, at least one microreaction chamber, at least one micro-instrumentation device, and at least one electronic microprocessor. The microreaction chamber supports at least one chemical reaction associated with a biological signaling pathway. The micro-instrumentation device measures at least one physical quantity associated with the signaling pathway. The microprocessor transmits electrical control signals, receives electrical measurement signals, and executes at least one software algorithm. The microreaction chamber is connected to the microfludic routing system to receive and transmit at least a fluid or gas, and the electronic microprocessor receives electrical measurement signals from the micro-instrumentation device via a first electric interface and transmits electrical control signals to electrically-controllable microfludic routing system via a second electrical interface.12-15-2011
20110307184LOW PERFUSION SIGNAL PROCESSING SYSTEMS AND METHODS - In some embodiments, systems and methods for identifying a low perfusion condition are provided by transforming a signal using a wavelet transform to generate a scalogram. A pulse band and adjacent marker regions in the scalogram are identified. Characteristics of the marker regions are used to detect the existence of a lower perfusion condition. If such a condition is detected, an event may be triggered, such as an alert or notification.12-15-2011
20090138206SYSTEM OF ANALYZING PROTEIN MODIFICATION WITH ITS BAND POSITION OF ONE-DIMENSIONAL GEL BY THE MASS SPECTRAL DATA ANALYSIS AND THE METHOD OF ANALYZING PROTEIN MODIFICATION USING THEREOF - The present invention relates to a method of analyzing protein modification. The method of invention for analyzing protein distribution and characteristics on one-dimensional gel provides the way to analyze proteins of samples on one-dimensional gel quantitatively and provides information on interactions among proteins and further can be effectively used for the development of a novel diagnostic and therapeutic method for a disease by screening a disease marker protein.05-28-2009
20090276160CRYSTAL STRUCTURE OF HEPATOCYTE GROWTH FACTOR ACTIVATOR COMPLEXED WITH KUNITZ DOMAIN INHIBITOR - The present disclosure provides crystals of and structural coordinates of Hepatocyte growth factor activator with and without bound pseudo-substrate or inhibitor. In a specific embodiment, a crystal structure of activated HGFA complexed with a Kunitz domain inhibitor is provided. The crystals and crystal structures are useful, for example, in the design and synthesis of inhibitors of HGFA.11-05-2009
20090240440Non-Invasive Glucose Monitoring - A monitoring system for monitoring the glucose level of a subject having a glucose level history is disclosed. The system comprises (a) a non-invasive measuring device, operable to measure and record an electrical quantity from a section of the subject body, so as to provide a time-dependence of the electrical quantity over a predetermined time-period. The system further comprises (b) a processing unit, communicating with the non-invasive measuring device. The processing unit comprises: an extractor, for extracting a plurality of parameters characterizing the time-dependence, a correlation function calculator for calculate a subject-specific correlation function, and an output unit, communicating with the correlation function calculator and configured to output the glucose level of the subject. The subject-specific correlation function describes the glucose level history and is defined over a plurality of variables, each corresponding to a different parameter.09-24-2009
20080262745Method for Determining Insulin Sensitivity and Glucose Absorption - The present invention encompasses a model-based method for determining insulin sensitivity and glucose absorption from oral glucose tolerance tests or mixed meals. The present invention has several advantages over current methods. The technique requires about four to six blood samples taken over about two to three hours following glucose ingestion and is therefore applicable to large-scale clinical trials. The analysis involves a reduced version of the classical minimal model, a method for describing glucose absorption using only two parameters, and an integral approach enabling the parameters to be obtained using simple algebra. The present method robustly identifies differences in insulin sensitivity in different patient types as well as improvements in insulin sensitivity arising from pharmaceutic therapy. In addition, insulin sensitivity measurements obtained with the present method are highly correlated with results from hyperinsulinemic clamps (r10-23-2008
20120041684Method of evaluating obesity, obesity-evaluating apparatus, obesity-evaluating method, obesity-evaluating system, obesity-evaluating program product, recording medium, and information communication terminal apparatus - According to the method of evaluating obesity of the present invention, amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated is measured, and the state of at least one of the apparent obesity, the non-apparent obesity and the obesity which are defined by the BMI and the VFA in the subject is evaluated based on the concentration value of at least one of Glu, Ser, Pro, Gly, Ala, Cys2, Tyr, Val, Orn, Met, Lys, Ile, Leu, Phe, and Trp contained in the measured amino acid concentration data of the subject.02-16-2012
20120041683Pathway recognition algorithm using data integration on genomic models (PARADIGM) - The present invention relates to methods for evaluating the probability that a patient's diagnosis may be treated with a particular clinical regimen or therapy.02-16-2012
20120065897PREDICTING RISK OF MAJOR ADVERSE CARDIAC EVENTS - Measurement of circulating ST2 and natriuretic peptide (e.g., NT-proBNP) concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, transplantation, and heart failure.03-15-2012
20120065896BIOLOGICAL AND CHEMICAL TEST MEDIA AND SYSTEM - An apparatus and method for performing medical, biological or chemical tests in the field is disclosed. In some embodiments, the test media comprises a special purpose optical disc which is read, after application of the test specimen and subsequent processing, using commonly available CD, DVD, High Definition DVD or Blu-Ray optical disc players.03-15-2012
20120065893Method and apparatus for mitigating aviation risk by determining cognitive effectiveness from sleep history - Method and apparatus for analyzing and managing fatigue primarily in but not limited to aviation occupations. The invention is adaptable to other occupations where assuring crew rest is critical. Graphical user interfaces (GUIs) allow for the insertion of sleep quantity, quality, and sleep interruptions over a number of days. The invention produces as an output the user's cognitive effectiveness ranging from high levels to critically low levels over a period of days.03-15-2012
20120150449Method of Using Human Physiological Responses As Inputs To Hydrocarbon Management Decisions - A method of analyzing hydrocarbon-related data is disclosed. Data representative of a hydrocarbon entity is presented. A physiological response of a viewer of the data is sensed. The physiological response is associated with the data. The data and a representation of the associated physiological response is outputted.06-14-2012
20100042330Non-Hypergeometric Overlap Probability - Methods, software, and systems are provided for determining the probability of an overlap set of entities having an overlap size, where the overlap set is independently selected from two sets of non-identical entities. Applications of the invention to microarrays are provided. Probability distributions are provided for determining the probability that the size of an overlap gene set from two different microarrays occurs by chance. Microarray analysis for determining the size of a statistically significant overlap gene set given two different microarrays is described. Overlap set size probability determinations that account for the total number of genes in two different microarrays and not just the common genes are described.02-18-2010
20100125417Food content detector - A system may include utensil means for portioning a foodstuff into a first portion and a second portion, a means for detecting a first portion size for the first portion with the utensil means, a means for detecting a second portion size for the second portion with the utensil means, and a means for determining a cumulative amount of portioned foodstuff based upon the first portion size and the second portion size.05-20-2010
20100299077SYSTEMS AND METHODS FOR APPLYING SCALING LAWS OF TREE STRUCTURES - In at least one embodiment, a method for determining the resistance of a flow within at least a portion of a vessel is provided, with the method comprising the steps of obtaining a biological tree image showing a structure of at least part of a biological tree, identifying a length of a vessel portion and a diameter of a stem vessel proximal to the vessel crown from the biological tree image, and calculating resistance based upon at least the length of a vessel portion and a diameter of a stem vessel proximal to the vessel crown. In another embodiment, a method for determining vessel volume is provided, with the method comprising the steps of obtaining a biological tree image showing a structure of at least part of a biological tree, identifying a diameter of a stem segment and a length of a stem segment from the biological tree image, and calculating cumulative crown volume based upon at least the diameter of the stem segment and the length of the stem segment.11-25-2010
20120046875METHOD AND SYSTEM FOR PROCESSING A PHYSIOLOGICAL SIGNAL - A method of signal processing, includes obtaining at least one physiological signal from a system (02-23-2012
20120209534METHOD AND SYSTEM FOR ANALYZING LIQUID - A method of analyzing liquid is disclosed. The method comprises: obtaining data pertaining to a dripping pattern characterizing formation of liquid drops as a function of the time, and comparing the dripping pattern to a reference dripping pattern.08-16-2012
20120046874CONSIDERATION OF EVIDENCE - A computer implemented method of comparing a test sample result set with another sample result set is provided, the method including: providing information for the first result set on the one or more identities detected for a variable characteristic of DNA; providing information for the second result set on the one or more identities detected for a variable characteristic of DNA; and comparing at least a part of the first result set with at least a part of the second result set; and wherein: the comparing includes a likelihood and the likelihood uses a probability density function conditioned on DNA quantity. Further benefits are obtained from the manner in which the probability density function is obtained and/or the use of probability density functions to account for stutter and/or allele dropout.02-23-2012
20120046876Computational methods and systems for suggesting modulators of CYP450 as treatment options - Computational methods and systems are described which accept input, identify one or more CYP450-family enzymes, identify one or more modulators of the CYP450-family enzymes, and communicate treatments to at least one system user, wherein the treatments include one or more of the identified at least one modulator.02-23-2012
20120004853Analysis System And Computer Implemented Method For Analyzing Biological Samples - Analysis system and computer implemented method for analyzing biological samples are disclosed. The system has at least one analyzer for performing an analysis and a decision unit being operable to determine in response to the receipt of the analysis request whether results obtained from performing the analysis on the sample indicated in the analysis request are valid. This determination is executed by retrieving the meta information assigned to the sample and by applying the at least one condition on the meta information and wherein the at least one applied condition has at least a condition on whether the sample allows a valid analysis on the sample, and wherein the decision unit returns the decision that the analysis exercised on the indicated sample will return a valid result in case the conditions of the condition set are met by the sample.01-05-2012
20120004858SYSTEM FOR ANALYZING EXPRESSION PROFILE, AND PROGRAM THEREFOR - The present invention provides a system for analyzing an expression profile in which a large number of expression profile data obtained by a next-generation high-speed sequencer, a similar experimental technique, or the like is analyzed at high speed by a general-purpose computer, gene expression patterns are visualized, thereby easily analyzing to which gene a novel gene is similar in function. A system for analyzing an expression profile which analyzes gene expression profile data includes a storage unit which stores the number of counts of mRNAs expressed from a subject gene to be evaluated as expression data under each of a plurality of gene expression conditions for each subject gene name, a correspondence analysis unit which reads the expression data from the storage unit for each subject gene, and carries out correspondence analysis on the basis of the number of counts under each expression condition in expression data, a coordinate conversion unit which converts n-dimensional (n: natural number) scores obtained by the correspondence analysis to coordinate values for m-dimensionally (m: natural number, m≦n) arranging each subject gene, and an image processing unit which carries out plotting along the corresponding coordinate values for each gene to display the result on an image display unit.01-05-2012
20120004856SPECTRAL DATA ANALYZER, BIOLOGICAL SUBSTANCE DETECTION SYSTEM, AND BIOLOGICAL SUBSTANCE DETECTION METHOD - A spectral data analyzer is disclosed. The spectral data analyzer calculates the spectral intensity ratio of a C—H band and an amide I band in a Raman spectrum that corresponds to a substance present in a body tissue; and automatically determines the presence or absence of amyloid beta in the substance based on the calculated ratio.01-05-2012
20120004855METHYLATION BIOMARKERS FOR PREDICTING RELAPSE FREE SURVIVAL - A methylation classification list comprising loci DNA, for which loci the methylation status of the DNA is indicative of likelihood of recurrence of cancer, is provided. Furthermore, a method, apparatus and use for predicting probability of relapse free survival of a subject diagnosed with cancer, are provided.01-05-2012
20120004854METABOLIC BIOMARKERS FOR OVARIAN CANCER AND METHODS OF USE THEREOF - Panels of serum metabolic biomarkers and methods of their use in detecting and diagnosing cancer, especially ovarian cancer, are disclosed. The metabolic biomarker panels include 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 50, 75, 100, 150, or more metabolites. Supervised classification methods, such as trained support vector machines (SVMs) are used to determine whether the levels of metabolic biomarkers in a subject are indicative of the presence of cancer. The disclosed biomarkers and methods preferably allow a diagnosis of cancer with an accuracy, a specificity, and/or a sensitivity of at least 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99%.01-05-2012
20120004852HAND HELD ANALYSIS DEVICE FOR ANALYZING A BODY FLUID AND A CONTROL METHOD THEREFOR - A method is provided for controlling a hand-held analysis device for analyzing a body fluid in which in each case at least one test means for single use is automatically provided in consecutive measuring cycles by means of a control device where each measuring cycle in a measuring mode of the control device is triggered by a start actuation. According to the invention it is proposed that a defined control intervention puts the control device into a maintenance mode in which the automatic provision of a test means is prevented.01-05-2012
20120004851FIELD-PORTABLE IMPEDANCE READER AND METHODS OF MAKING THE SAME - A field-portable impedance reader is provided. The impedance reader comprises a reader antenna, an impedance compensator, a calibrator, and a synchronous sampler. The impedance reader further comprises a digital processor that receives and processes signals from the synchronous sampler. Further, a wireless system comprising the impedance reader of the invention is provided.01-05-2012
20120004857THROUGHPUT INFORMATION GENERATING APPARATUS OF SAMPLE ANALYZER, SAMPLE ANALYZER, THROUGHPUT INFORMATION GENERATING METHOD OF SAMPLE ANALYZER, AND COMPUTER PROGRAM PRODUCT - An apparatus for generating throughput information of a sample analyzer is disclosed. Specifically, this apparatus generates throughput information of a sample analyzer capable of measuring a sample on a plurality of measurement items in which measurement time differs from each other. The apparatus receives an input of a plurality of measurement orders, wherein a measurement order includes a designation of at least one measurement item, generates the throughput information of the sample analyzer based on the received plurality of measurement orders; and outputs the generated throughput information.01-05-2012
20100017146AUTO-ANALYSIS FRAMEWORK FOR SEQUENCE EVALUATION - An automated system for evaluating biological samples which includes a centralized registry that contains protocols and configuration information for both instruments and analysis applications. The registry provides for improved automation of biological process runs using an autoanalysis applications manager component or daemon, which accesses and transmits the appropriate protocol and configuration information to selected instruments and/or applications. This information is used to instruct data capture by the biological instruments and direct the analysis of the data by the analysis applications.01-21-2010
20100241357Single-Cell Raman Spectroscopy for the Non-Destructive, Non-Invasive Analysis of Cells and Cellular Components - Raman spectra of cells, such as normal human T- and B-cells from peripheral blood or human tonsil and the corresponding transformed cells are obtained by optically trapping the cells and obtaining their Raman spectra. The trapped cells can be subjected to one, two, or more different excitation wavelengths, and each wavelength of the corresponding Raman spectra can be stored in a separate channel. In preferred embodiments, two spectra are subtracted from each other to give a difference spectrum and each channel is analyzed independently to characterize the trapped cell. Alternatively, the Raman spectrum can be subjected to Principal Component Analysis (PCA) in order to characterize the trapped cell. The trapped cell thus classified can be sorted, or further manipulated.09-23-2010
20110010102Methods and Systems for Sequence-Directed Molecular Breeding - The present invention provides breeding methods and compositions to enhance the germplasm of a plant by the use of direct nucleic acid sequence information. The methods describe the identification and accumulation of preferred nucleic acid sequences in the germplasm of a breeding population of plants.01-13-2011
20120010822FLUORESCENCE INTENSITY COMPENSATION METHOD AND FLUORESCENCE INTENSITY CALCULATION DEVICE - A fluorescence intensity compensation method, includes: receiving, with photodetectors having different input wavelength bands, fluorescence emitted from fluorochromes excited by irradiating light on microparticles multiply-labeled by a plurality of fluorochromes with overlapping fluorescence wavelengths; collecting detected values for the photodetectors; and obtaining a measurement spectrum, by approximating, from the linear sum of single-stain spectrums obtained from microparticles individually labeled with the fluorochromes; wherein approximation of the measurement spectrum by the linear sum of the single-stain spectrums is performed using the restricted least-square method.01-12-2012
20090012715Prediction model of graft survival - Described are methods of predicting graft survival based on pre-transplant variables. A logistic regression (LM) and/or a tree-based model (TBM) are used to identify predictors of graft survival and to generate prediction algorithms. Both the logistic regression model and the tree-based model may be used in clinical practice for long term prediction of graft survival based on pre-transplant variables. The invention is also directed to computer software, which includes a logistic regression model and/or a tree-based model to select pre-transplant variables and generate a graft survival algorithm and to calculate a graft survival probability, and for selecting appropriate organ donors and recipients to optimize the graft survival probability.01-08-2009
20110166793METHOD AND APPARATUS FOR DETERMINING ANIMAL RELATIONSHIPS - A system and method of determining a relationship between a first animal (07-07-2011
20110166792INSULIN RESISTANCE EVALUATION SUPPORTING SYSTEM, INSULIN RESISTANCE EVALUATION SUPPORTING METHOD, AND COMPUTER PROGRAM PRODUCT - The present invention provides an insulin resistance evaluation supporting system, an insulin resistance evaluation supporting method, and a computer program product that can reduce the burden on a subject necessary to estimate biological information relating to the insulin resistance compared with that in conventional examples. An insulin resistance evaluation supporting system 07-07-2011
20110166791METABOLIC MONITORING, A METHOD AND APPARATUS FOR INDICATING A HEALTH-RELATED CONDITION OF A SUBJECT - An apparatus for indicating a health-related condition of a subject has an input interface for receiving a sequence of samples of a first biological quantity derived by a first measurement method, the first measurement method being an invasive measurement and having a first impact on the subject, and for receiving a sequence of samples of a second biological quantity derived by a second measurement method, the second measurement method being a non-invasive measurement and having a second impact on the subject, wherein the first biological quantity gives a more accurate indication of the health-related condition of the subject than the second biological quantity, wherein the first biological quantity and the second biological quantity have a correlation to the health-related condition of the subject, and wherein the second impact is smaller than the first impact; a predictor for providing, for a certain time, for which no sample for the first biological quantity exists, an estimated value of the first biological quantity using samples for the first biological quantity and, as far as available, samples for the second quantity; and an output interface for outputting the estimated value or data derived from the estimated value so that an indication for the health-related condition of the subject is obtained.07-07-2011
20100198520Method, System and Computer Program Product for Evaluation of Insulin Sensitivity, Insulin/Carbohydrate Ratio, and Insulin Correction Factors in Diabetes from Self-Monitoring Data - A method, system and computer program product for evaluating or determining a user's insulin sensitivity (SI). An initial step or module may include acquiring SMBG readings from a predetermined period. Another step or module may include computing an estimate of insulin sensitivity (SI) from the SMBG readings. Another step or module may include using the estimate of SI to compute individualized carbohydrate ratio. Additionally, another step or module may include using the estimate of SI to compute individualized correction factor. The computation of the two components of an insulin dose calculator, carbohydrate ratio and correction factor, uses this estimate, which allows the tailoring of carbohydrate ratio and correction factor to the present state of the person.08-05-2010
20120016596BIOLOGICAL INFORMATION MANAGEMENT SYSTEM AND BIOLOGICAL INFORMATION MANAGEMENT METHOD - A measurement result management system suited for storing biological information measured with a measuring equipment in a server is provided. The measurement result management system includes a measuring equipment for measuring and transmitting biological information, and a server for receiving the biological information from the measuring equipment and storing the same, wherein the measuring equipment performs a step of transmitting authentication related information related to authentication of the measuring equipment when transmitting the biological information with a communication unit, and the server performs a step of carrying out authentication based on the authentication related information, and steps of storing the biological information acquired through a communication unit in a storage unit regardless of whether the authentication result of the step of carrying out authentication based on authentication related information is positive or negative.01-19-2012
20120016595TRANSCRIPT MAPPING METHOD - A transcript mapping method according to an embodiment of the invention is described hereinafter and combines short tag based (SAGE and MPSS) efficiency with the accuracy of full-length cDNA (flcDNA) for comprehensive characterization of transcriptomes. This method is also referred to as Gene Identification Signature (GIS) analysis. In this method, the 5′ and 3′ ends of full-length cDNA clones are initially extracted into a ditag structure, with the ditag concatemers of the ditag being subsequently sequenced in an efficient manner, and finally mapped to the genome for defining the gene structure. As a GIS ditag represents the 5′ and 3′ ends of a transcript, it is more informative than SAGE and MPSS tags. Segment lengths between 5′ and 3′ tag pairs are obtainable including orientation, ordering and chromosome family for efficient transcript mapping and gene location identification. Furthermore, a compressed suffix array (CSA) is used for indexing the genome sequence for improve mapping speed and to reduce computational memory requirements.01-19-2012
20120209532PORTABLE EVALUATOR OF AMOUNT OF EXERCISE AND THE METHOD OF EVALUATING AMOUNT OF EXERCISE - A portable evaluator of amount of exercise detects an acceleration and angular speed of the user. After using an exercise identifying procedure to identify the exercise type, the portable evaluator finds a corresponding strength formula to evaluate the amount of exercise done by the user. The result is displayed for reference. By detecting the acceleration and angular speed, the portable evaluator identifies exercise types that involve rotations. Different formulas are used for different kinds of exercise.08-16-2012
20130013216LIBRARIES AND DATA STRUCTURES OF MATERIALS REMOVED BY DEBULKING CATHETERS - Material removed by a debulking catheter from a body lumen can be preserved. Materials can be collected from many different patients and/or from multiple procedures on individual patients. Data which describe the properties or qualities of the removed material and/or the patient and/or the patient's family or environment can be stored on computer readable media. The stored data can be used to draw correlations, to stratify groups of patients, to provide risk assessments, to provide diagnoses and/or prognoses. Further tests can be done on the stored materials at later times after the procedures have been completed.01-10-2013
20120116686Melting Curve Analysis with Exponential Background Subtraction - A method for clustering melting profiles of a plurality of nucleic acid samples, comprising measuring the fluorescence of each nucleic acid sample as a function of temperature to produce a respective raw melting curve for each respective nucleic acid sample, and clustering genotypes of the plurality of nucleic acid samples to form a plurality of clusters of melting curves. A system for analyzing a plurality of nucleic acid samples comprising an instrument for sequentially heating fluorescently detectable complexes while monitoring their fluorescence, a central processing unit (CPU) for performing computer executable instructions, and a memory storage device for storing computer executable instructions that when executed by the CPU cause the CPU to cluster genotypes of a plurality of nucleic acid samples.05-10-2012
20120116685Methods, System, And Medium For Associating Rheumatoid Arthritis Subjects With Cardiovascular Disease - The present invention relates to a system and a medium for analyzing one or more analytes in rheumatoid arthritis subjects to determine whether the subject is at increased risk of diseases such as a cardiovascular disease, the subject's current cardiovascular disease burden, and the likelihood of cardiovascular disease progression in the subject. In addition, the present invention further provides methods for analyzing data to determine risk of cardiovascular disease, current cardiovascular disease burden, and the likelihood of cardiovascular disease progression in a rheumatoid arthritis subject.05-10-2012
20100268473METHODS, DEVICES, AND COMPOSITIONS FOR THE HIGHLY-SENSITIVE DETECTION AND IDENTIFICATION OF DIVERSE MOLECULAR ENTITIES - Embodiments of the present disclosure include a method for analysis of individual components in a multicomponent sample where the identity of the individual components is an indicator for disease.10-21-2010
20100017141CALCULATING INSULIN ON BOARD FOR EXTENDED BOLUS BEING DELIVERED BY AN INSULIN DELIVERY DEVICE - A system and method may be used to calculate insulin on board (IOB) for an extended bolus being delivered by an insulin infusion pump. In general, the system and method calculates an extended bolus IOB value for the extended bolus, which takes into account the insulin currently on board from the extended bolus and the insulin scheduled to be delivered by the extended bolus over a subsequent time period equivalent to a duration of insulin action. The extended bolus IOB value may be used to calculate a suggested bolus.01-21-2010
20120022792METHOD OF QUANTIZATION OF MAGNETIC NANOPARTICLE ABSORPTION INTO ANIMAL TISSUES, AND EQUIPMENT FOR DOING IT - A method of quantization of magnetic nanoparticle absorption in animal tissues includes determination of the number of magnetic nanoparticles absorbed in animal tissues by magnetization measurements. The method is based on the measurement of magnetization versus magnetic field applied of the tissue sample absorbed with the nanoparticles obtaining their saturation magnetization. This magnitude is compared to the saturation magnetization of the same nanoparticles found in the tissue for the determination of the absolute number of magnetic nanoparticles in the animal tissue studied. The method includes preparing the samples for the sample holder, measuring the magnetization vs. applied magnetic field of a known number of magnetic nanoparticles, determining the saturation magnetization of the sample to be studied by measuring the magnetization and calculating the nanoparticle mass in the tissues from the data measured (saturation magnetization of the sample and of calibration of nanoparticles).01-26-2012
20120022793BIOMARKERS FOR THE DIAGNOSIS OF PROSTATE CANCER IN A NON-HYPERTENSIVE POPULATION - The present invention includes the use of biomolecules for differential diagnosis of prostate cancer and/or non-malignant disease of the prostate. The present invention also provides methods for detecting biomolecules within a biological sample. The invention further includes kits for differential diagnosis of prostate cancer and/or non-malignant disease of the prostate in a biological sample.01-26-2012
20120059597Computational methods and systems for treatment in relation to modulation of CYP450 enzyme activity - Methods and systems such as those described herein include accepting input, identifying CYP450-family enzymes, identifying at least one modulator of an enzyme, and communicating one or more treatments to a system user.03-08-2012
20120059596SYSTEM AND METHOD FOR DETERMINING A DOSAGE FOR A TREATMENT - An system and method for allowing the real-time diagnostics of various genotype-related treatments while allowing for the changing of demographic data such as a person's age, weight, etc. Various embodiments and methods of new processes include the assembly and association of genetic material samples, the preparation of microarrays with representative genetic material samples in a pattern best suited for analysis as well as manipulation, and delivery of assimilated and compiled data in the form of an electronic document for determining a dosage for a treatment.03-08-2012
20120059595SYSTEM AND METHOD FOR HIGH-CONTENT ONCOLOGY ASSAY - The present invention provides an apparatus, system, method and computer program and computer program product for analyzing cellular samples. One embodiment of the apparatus and method provides a multiparameter assay that provides information with respect to cell proliferation, cell cycling and cell death. The multiparameter assay is particularly useful for assessing and screening candidate compounds for anti-cancer utility.03-08-2012
20120059594COMPOSITIONS AND METHODS FOR DISCOVERY OF CAUSATIVE MUTATIONS IN GENETIC DISORDERS - The compositions and methods provided herein allow for identification of causative genetic biomarkers for a disease condition or drug response.03-08-2012
20120059593Method for Determining the Stroke Volume of a Heart, Method for Determining the Electrode Positions Therefor, and Sheet Shaped Device Therefor - Method for determining the stroke volume of a heart comprising: attaching electrodes to the front legs or arms or head, and the hind legs of the body; connecting an alternating current source to the left pair of front legs/arms or head, and hind legs; connecting an alternating current source to the right pair of front legs/arms or head, and hind legs; attaching a number of electrode pairs to the thoracic skin, such that the electrodes are in contact with the skin of the thorax at predetermined positions, wherein the electrode pairs are each connected to an independent input of a data acquisition/calculation device; determining the beginning the cardiac cycle and measuring with the number of electrode pairs on the thorax the voltage at the beginning of the cardiac cycle at the predetermined positions; measuring during the cardiac cycle with the number of electrode pairs on the thorax the voltages at the predetermined positions and determining the voltage changes V03-08-2012
20090192723Dosimeter for vibrations - The present invention relates to an arrangement for calculation and presentation of transferred vibration dose from a handheld machine to the hand of a user, wherein a sensor unit 07-30-2009
20110093211Method for Processing Protein Data - A method of generating data indicating whether a set of proteins is a protein complex. The method comprises receiving as input experimental data indicating experimentally observed relationships, each experimentally observed relationship being between a first protein and zero or more second proteins and generating data indicating whether the set of proteins is a protein complex. The experimental data is processed to determine a first data value indicating a number of proteins having a relationship with one or more second proteins and a second data value indicating a number of proteins having a relationship with a selected protein.04-21-2011
20110093210MEASUREMENT DEVICE AND METHOD OF CONTROLLING THE SAME - A measurement device includes: a first measurement unit (04-21-2011
20110093208LEAST-SQUARE DECONVOLUTION (LSD): A METHOD TO RESOLVE DNA MIXTURES - Least Square Deconvolution (LSD) uses quantitative allele peak data, for example, allele peak area, allele peak height and optical density, derived/obtained from a sample containing the DNA of more than one contributor to resolve the best-fit genotype profile of each contributor. The resolution is based on finding the least square fit of the mass ratio coefficients at each locus to come closest to the quantitative allele peak data. Consistent top-ranked mass ratio combinations from each locus can be pooled to form at least one composite DNA profile at a subset of the available loci. The top-ranked DNA profiles can be used to check against the profile of a suspect or be used to search for a matching profile in a DNA database.04-21-2011
20110093207System for Conducting the Identification of Bacteria in Biological Samples - The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.04-21-2011
20110093206METHODS, SYSTEMS, AND PRODUCTS FOR QUANTITATIVELY MEASURING THE DEGREE OF CONCORDANCE BETWEEN OR AMONG MICROARRAY PROBE LEVEL DATA SETS - Methods, systems and products are provided to quantitatively measure the degree of concordance between or among microarray probe level data sets. These can include the steps of evaluating outlier probe values, determine gene expression scores, evaluating the significant treatment effect for each gene expression score, and determining concordance between replicate data sets04-21-2011
20110093205PROTEOMICS PREVIEWER - A technique for analyzing proteomics data (such as tandem mass-spectrometry data) corresponding to peptides in a sample is described. In a high-speed, low-sensitivity first pass of this analysis technique, analysis parameters, such as the presence of one or more potential modifications to the one or more peptides, are determined using a representative subset of a database of known proteins. For example, a given potential modification in the one or more potential modifications may be determined by comparing matches between measured mass-spectrometry spectra and generated theoretical mass-spectrometry spectra without the given potential modification to matches between the measured mass-spectrometry spectra and generated theoretical mass-spectrometry spectra with the given potential modification. Then, in a lower-speed, higher-sensitivity second pass of the analysis technique, one or more peptides and/or proteins in the proteomics data are identified using the database of known proteins and the determined analysis parameters.04-21-2011
20110093204Methods and system for the identification and characterization of peptides and their functional relationships by use of measures of correlation - The invention provides methods and a system implementing these methods for identifying and characterizing peptides and their functional relationships by use of measures of correlation. These methods are based on the interaction of a Correlation Associated Network Module with several Application Modules including a Sequence Network Module, a Differential Network Module, a Marker Panel Network Module and a Surrogate Network Module allowing e.g. the provision of a representative overview of the peptide content of biological samples, the prediction of peptide sequences, the identification of peptides suitable to be used as marker panels and the identification of peptides suitable as surrogates for a known peptide.04-21-2011
20120158311APPARATUS FOR REGISTRATION OF TRANSITIONS BETWEEN PSYCHOPHYSIOLOGICAL STATES OF INDIVIDUAL AND METHOD FOR PERFORMING THE SAME - The invention relates to a field of medicine and medical devices. An apparatus for registration of transitions between psychophysiological states of individual comprising a reading unit arranged to be capable of measuring an electromotive force under direct electric current of 0.5 to 5.0 microampere to produce a signal; at least two electrodes connected to reading unit, electrodes arranged to be capable of fixing upon the body of individual; a logarithmic unit, quantization unit comprising a comparator arranged to be capable of determining of whether the difference between the current and the previous signal value is greater than N, where N is a predefined value from 0.1 to 2.0 centineper; and a pulse generator arranged to be capable of generating a pulse having an amplitude of N when the difference between the current and the previous signal value is greater than N; the apparatus further comprising a compensating unit, a processing unit capable of monitoring the pulse values; and at least one power supply. A method for registration of psychophysiological state transition of individual comprises the following steps: (a) measuring of electromotive force between electrodes fixed upon the skin of individual under flow of direct current in interval from 0.5 to 5.0 microampere; (b) logarithming of signal; (c) quantizing the logarithm of signal from step (b) by level from 0.1 to 2.0 centineper; and (d) determining a transition between psychophysiological state of the individual either by registering sudden increase of unidirectional signal pulses amount, or by registering a shift in signal level up to 1.5-3.0 fold as compared to initial value.06-21-2012
20120209535METHOD FOR GENERATING BIOMARKER REFERENCE PATTERNS - The present invention relates to methods for evaluating biomarkers. In particular, the invention relates to a method for establishing at least one pattern for at least one pre-defined effector having at least one effect on a biological system, which effect is capable of being determined, to a method of establishing a class of effectors for a pre-defined effect or group of effects, to a method for identifying at least one effect of a pre-defined effector and to a computer program and a computer adapted to carry out these methods.08-16-2012
20080294349Quantitative Evaluation and Image Analysis of Choroidal Neovascular Membrane and Other Retinal and Subretinal Lesions - The present invention can be a method to allow a user to extract and calculate objective data in a reproducible indicator of the initial evaluation, progression or regression of the activity of choroidal neovascularization or other retinal and subretinal lesions summarized as a single number. The method can be applied to either OCT, FA or both as diagnostic tools depending upon the preference of the user and can be used as the steps of Data Collection, Data and Image Analysis, and Computations. The present invention further provides a user a formula for Approximate Lesion Volume, Flourescein index, the change in the flourescein index, lesion volume index, the active lesion volume change, or the regression factor as well as the severity index. The present invention can also be automated in a program to calculate the desired indexes for the user.11-27-2008
20120209533ACTIVITY MONITOR, METHOD OF CALCULATING TARGET ACTIVITY AMOUNT, AND STORAGE MEDIUM - The activity monitor (08-16-2012
20110098935TECHNIQUES FOR DETERMINING THE EFFECTS ON A SYSTEM OF A COMPONENT THAT HAS FOUR STATES - Techniques for determining effects on a biological system include determining rate constants for a particular time interval starting at an initial time. Each rate constant indicates a rate of transition from one of four states to a different one of the four states for a component of a biological system in presence of an external factor. A temporal change in a probability that the component is in a particular state after the initial time is determined without numerical iteration over multiple time steps. This includes determining three relaxation time constants that describe exponential changes based on the rate constants. The effect of the external factor on the biological system is determined based on the temporal change in the probability that the component is in the particular state. The probability at an arbitrary time is determined based on the rate constants and initial probabilities.04-28-2011
20120072120AUTOMATIC THRESHOLD SETTING AND BASELINE DETERMINATION FOR REAL-TIME PCR - The invention discloses a system and methods for quantitating the presence of nucleic acid sequences by evaluation of amplification data generated using real-time PCR. In one aspect, the methods may be adapted to identify a threshold and threshold cycle for one or more reactions based upon evaluation of exponential and baseline regions for each amplification reaction. The methodology used in the analysis may be readily automated such that subjective user interpretation of the data is substantially reduced or eliminated.03-22-2012
20120072121SYSTEMS AND METHODS FOR QUALITY CONTROL OF COMPUTER-BASED TESTS - Disclosed are systems and methods for monitoring, inter alter, administration compliance, test subject identity, and results quality of computer-administered tests. A test administration unit, an audio-visual data collection unit, and an audio-visual data processing unit are configured to detect testing anomaly events within the testing environment by analyzing audiovisual data from the test subject and environment itself. Disclosed methods include modifying or amending test results because of detected testing anomaly events within the testing environment, verifying the identity of the test subject, and monitoring for compliance with test-administration protocols. Additional methods disclosed include: user facial analysis, including gaze point analysis, for indirect detection of testing anomaly events; user verification using facial recognition, voice recognition, retinal scans, and or other audiovisual biometric protocols; and the like.03-22-2012
20120072118VARIATION ANALYSIS FOR MULTIPLE TEMPLATES ON A SOLID SUPPORT - Disclosed herein are compositions and methods used for detecting different types of molecules associated with a site on a solid support.03-22-2012
20120072119Methods To Diagnose Treat and Prevent Bone Loss - Methods of diagnosing and preventing bone loss and/or enhancing bone formation are disclosed. The invention additionally provides methods of diagnosing a predisposition to bone loss. The methods mathematically combine the information provided by imaging tests with the information provided by biomarkers to provide an index value. The index value is used for diagnosis of bone diseases, and to assess the progress of treatment of bone diseases.03-22-2012
20120179387Method for Urodynamics Testing and Analysing - A method for urodynamics testing and analysing comprises the steps of building an elastic element model of urethral bladder; building an urethral model; keeping anterior urethra perpendicular to the direction of gravity, measuring and recording urination data and calculating urination parameters; calculating the contraction length of the elastic element, further calculating the contraction velocity and contraction acceleration of the elastic element, and assessing the contraction function of detrusor muscle by using the maximum contraction acceleration of the elastic element; and learning the measurement of urethral resistance by using the cross-section area of the urethral model, and finding out the state of urethral obstruction by using the maximum cross-section area.07-12-2012
20120078523METHODS FOR ISOLATION AND VIABILITY ASSESSMENT OF BIOLOGICAL ORGANISMS - Isolation of biological or chemical organisms can be accomplished using a surface enhanced Raman scattering (SERS) system. The SERS system can be a single or a stacked plurality of photonic crystal membranes with noble-metal lined through pores for flowing analyte potentially containing the biological or chemical organisms. The through pores can be adapted to trap individual biological or chemical organisms and emit SERS spectra, which can then be detected by a detector and further analyzed for viability of the biological or chemical organism.03-29-2012
20120179386INTEGRATED SELF-CONTAINED RECORDER OF BIOLOGICAL DATA FOR SMALL ANIMAL RESEARCH - An apparatus and method for the recording of physiological variables in small animals are described. The apparatus is an integrated self-contained recorder including a converter of biological signals into a digital form, a data storage unit, a data output for transporting the stored data from the recorder after the end of recording session, a power source and an electrical connector arranged for connection of the recorder with at least one sensor of biological signal and mechanical fixation of the recorder at the head of an animal. The recorder may contain a sensor, which receives signals from an external source for synchronization of the stored data with external equipment or observed/registered animal behavior.07-12-2012
20110066383Indentifying One or More Activities of an Animate or Inanimate Object - Methods, systems and apparatus for identifying an activity of an animate or inanimate object are disclosed. One method includes identifying each elemental motion of a sequence of elemental motions of a device attached to the animate or inanimate object. The activity of the animate or inanimate object can be identified by matching the sequence of identified elemental motions of the device with a library of stored sequences of elemental motions, wherein each stored sequence of elemental motions corresponds with an activity.03-17-2011
20110066385QUANTIFICATION OF DIFFERENCES BETWEEN MEASURED VALUES AND STATISTICAL VALIDATION BASED ON THE DIFFERENCES - A system and method of validating differences between measured values of fluorescence intensities obtained from a fluorescence-based instrument, including: generating calibration histograms for calibration beads run through the instrument; calibrating a distance function configured to measure distances between the histograms by: constructing a metric using the distance function, which includes a bin-to-bin dissimilarity matrix; and populating the dissimilarity matrix to maximize the following conditions: (A) the distance function of two histograms representing two sets of different beads equals the difference of their MESF values; and (B) the distance function of two histograms representing fluorescence of two sets of identical beads is zero; applying the metric to flow cytometry histograms generated for biological samples, to determine distances between the histograms; constructing a statistical test using the metric to determine a statistical significance of the distances; and determining whether the histogram results from the biological samples are reliable based on the statistical significance.03-17-2011
20110066382SYSTEMS AND METHODS FOR DETECTING NORMAL LEVELS OF BACTERIA IN WATER USING A MULTIPLE ANGLE LIGHT SCATTERING (MALS) INSTRUMENT - A particle detection system uses a camera to produce a picture based on the scattered light generated by a particle in a liquid medium, when a laser beam is incident on the particle. These pictures are then automatically analyzed through the use of a processing system (e.g., a computer). The processing system is configured to record the forward scattering intensity (e.g., amplitude) and the picture of the scattered light rays to generate a classification of the particle causing the scattering. Count rate and trends of the classified particles are monitored to detect a change that is representative of the overall health safety of the water or by knowing the levels of bacteria in process water, such as Reverse Osmosis (RO) feed water, reject brine, and product water, the operator may better monitor the life and condition of the RO membrane.03-17-2011
20110066381METHOD AND APPARATUS FOR ARTIFACTS MITIGATION WITH MULTIPLE WIRELESS SENSORS - Certain aspects of the present disclosure relate to a technique for mitigating artifacts of biophysical signals in a body area network. Information from multiple sensors (including motion information of the body) can be employed in mitigating the artifacts. The biophysical signals in the body area network can be compressively sensed.03-17-2011
20110066384Computer Aided Ligand-Based and Receptor-Based Drug Design Utilizing Molecular Shape and Electrostatic Complementarity - Methods related to the generation of shape signatures representing molecular shape, and using shape signatures in both ligand-based and receptor-based molecular design. Ray-tracing is used to explore the volume interior to a ligand, or the space exterior to a receptor site. Shape signatures are then probability distributions derived from the ray-traces. Shape signatures provide condensed descriptors of shape properties readily compared to each other to test for shape similarity or complementarity.03-17-2011
20100094560METHODS FOR DIAGNOSING IRRITABLE BOWEL SYNDROME - The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with irritable bowel syndrome (IBS). In particular, the present invention is useful for classifying a sample from an individual as an IBS sample using a statistical algorithm and/or empirical data. The present invention is also useful for ruling out one or more diseases or disorders that present with IBS-like symptoms and ruling in IBS using a combination of statistical algorithms and/or empirical data. Thus, the present invention provides an accurate diagnostic prediction of IBS and prognostic information useful for guiding treatment decisions.04-15-2010
20110029252HIGH CONFIDENCE IN POSITIVE STATUS DETERMINATION - Systems, methods, and apparatus for determining whether a culture in a vessel contains a plurality of microorganisms are provided. A normalization relative value is calculated for each respective measurement of a biological state of the culture between (i) the respective measurement and (ii) an initial biological state. For each fixed interval of time points, a derivative of the normalization relative values in the interval of time points is calculated, thereby forming a plurality of rate transformation values. For each set of rate transformation values in the plurality of rate transformation values, a measure of central tendency of the values in the set is computed, thereby forming a plurality of average relative transformation values. A determination whether the culture contains the microorganisms is made based on whether any calculated average relative transformation value exceeds a first threshold or whether an extent of growth exhibited by the culture exceeds a second threshold.02-03-2011
20110029251Methods for Identifying DNA Copy Number Changes - Methods of identifying allele-specific changes in genomic DNA copy number are disclosed. Methods for identifying homozygous deletions and genetic amplifications are disclosed. An array of probes designed to detect presence or absence of a plurality of different sequences is also disclosed. The probes are designed to hybridize to sequences that are predicted to be present in a reduced complexity sample. The methods may be used to detect copy number changes in cancerous tissue compared to normal tissue. The methods may be used to diagnose cancer and other diseases associated with chromosomal anomalies.02-03-2011
20110029250Non-Parametric Modeling Apparatus and Method for Classification, Especially of Activity State - The activity state classification method of the present invention employs a kernel-based modeling technique, and more specifically a set of similarity-based models, which have been created using example data, to process an input observation or set of input observations, each comprising a set of sensor readings or “features” derived there from or other data, to predict the activity state of a person from whom the sensor data was obtained. A model is created for each class of activity. The input data is processed by each model and the resulting predictions are combined to yield a final prediction of which state of activity is represented by the input data.02-03-2011
20110029249DETERMINATION OF BLOOD VOLUME IN A CULTURE BOTTLE - Systems, methods and apparatus for determining an amount of blood in a blood culture are provided where an initial biological state and then periodic measurements of the biological state of the culture are taken. For each respective measurement, a normalization relative value between the respective measurement and the initial measurement is made thereby forming normalization relative values. For each interval of time points represented by the normalization relative values, a first derivative of the normalization relative values in the interval is made thereby forming a plurality of rate transformation values. For each set of rate transformation values in the plurality of rate transformation values, an average relative transformation value is computed, thereby forming average relative transformation values. A lookup table that matches a measure of central tendency of the average relative transformation values to a blood amount is used to determine the amount of blood in the culture.02-03-2011
20120123694Method for Evaluating Renal Function - Plasma concentration of a compound of interest is measured in two or ideally 4 or more blood samples taken from a patient over a period of time following bolus injection. The measured values are input into a computer processor programmed to execute a computer program comprising an algorithm that uses the gamma variate (GV) function to model drug plasma concentration, then uses Tikhonov regularization to perform the fit, selecting a regularization constant so that the relative error in the plasma clearance is minimized. One or more output values representative of renal function are generated.05-17-2012
20120123693Device and method for responding to influences of mind - Mental influence detectors and corresponding methods are useful for detecting an influence of mind and hidden or classically non-inferable information. An anomalous effect detector includes a source of non-deterministic random numbers, a converter to convert a property of numbers, a processor to accept converter output and to produce an output signal representative of an influence of mind. The processor output signal contains fewer numbers than the input. A quantum computer includes a physical source of entropy to generate output numbers; a source of test numbers; a measurement processor to accept output numbers and to measure a relationship between process numbers and at least one test number to produce an output representative of an influence of mind.05-17-2012
20120123692Method And Apparatus For Providing Data Processing And Control In A Medical Communication System - Methods and apparatus for providing data processing and control for use in a medical communication system are provided.05-17-2012
20120123691Method and Device for Early Signal Attenuation Detection Using Blood Glucose Measurements - Methods and devices to detect analyte in body fluid are provided. Embodiments include receiving one or more analyte sensor data, receiving a reference measurement value associated with an analyte level, determining a sensitivity parameter based on the received one or more analyte sensor data and the reference measurement value, performing a probability analysis based on prior analyte sensor data to determine presence of signal attenuation, and generating an output value based on the probability analysis.05-17-2012
20120123690REAL-TIME SELF-CALIBRATING SENSOR SYSTEM AND METHOD - A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.05-17-2012
20120123689METHODS AND SYSTEMS FOR DISCRIMINATING BANDS IN SCALOGRAMS - The present disclosure is directed towards embodiments of systems and methods for discriminating (e.g., masking out) scale bands that are determined to be not of interest from a scalogram derived from a continuous wavelet transform of a signal. Techniques for determining whether a scale band is not of interest include, for example, determining whether a scale band's amplitude is being modulated by one or more other bands in the scalogram. Another technique involves determining whether a scale band is located between two other bands and has energy less than that of its neighboring bands. Another technique involves determining whether a scale band is located at about half the scale of another, more dominant (i.e., higher energy) band.05-17-2012
20120123688RAMAN SPECTROSCOPY FOR BIOPROCESS OPERATIONS - A method of characterizing a multi-component mixture for use in a bioprocess operation that includes providing a multi-component mixture standard with pre-determined amounts of known components; performing a Raman Spectroscopy analysis on the multi-component mixture standard; providing a multi-component test mixture from the bioprocess operation; performing a Raman Spectroscopy analysis on the multi-component test mixture; and comparing the analysis of the multi-component mixture standard and the multi-component test mixture to characterize the multi-component test mixture. In one embodiment, the multi-component mixture standard and the multi-component test mixture both comprise one or more of, at least two, at least three of, or each of, a polysaccharide (e.g. sucrose or mannitol), an amino acid (e.g., L-arginine, L-histidine or L-ornithine), a surfactant (e.g. polysorbate 80) and a pH buffer (e.g., a citrate formulation).05-17-2012
20120123687ANALYSIS OF DNA SAMPLES - The invention provides an improved method for obtaining information about DNA analysis of samples of uncertain origin by establishing the likelihood that they arose in certain manners compared with other possible manners. In this way all of the analysis information is taken into account and likelihood ratios are provided to express the results. The invention is particularly useful in analysing small DNA samples or DNA samples where the contribution from one or more sources is small.05-17-2012
20120123686HANDHELD DIAGNOSTIC TEST DEVICE AND METHOD FOR USE WITH AN ELECTRONIC DEVICE AND A TEST CARTRIDGE IN A RAPID DIAGNOSTIC TEST - A handheld diagnostic test device includes a port to removably receive a test cartridge, an element connected with an electronic device, and sensors for detection of test data from a biological or environment sample after reaction with reagents onboard the cartridge. The test device also includes memory storing algorithms for upload to the electronic device to enable a processor thereof: to await elapse of a pre-determined time following reaction of the sample with the reagents; to thereafter instruct the sensors to detect the test data; to generate presentation data based on the test data; and to present the presentation data from a presentation element of the electronic device to a user. A related method includes a connecting step, an up-loading step, a presentation step, a cartridge inserting step, a waiting step, a sensing step, and an electronic device processing step.05-17-2012
20120123685SECONDARY STRUCTURE DEFINING DATABASE AND METHODS FOR DETERMINING IDENTITY AND GEOGRAPHIC ORIGIN OF AN UNKNOWN BIOAGENT THEREBY - The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.05-17-2012
20090132173COMPUTING LIKELIHOOD RATIOS USING PEAK HEIGHTS - Methods for comparing a first DNA profile with a second DNA profile are provided. The likelihood ratio for one hypothesis relative to another, as to the sources of the DNA, is conditioned on quantity of DNA in the test sample providing the first DNA profile and/or another sample providing the second DNA profile.05-21-2009
20090132174SEAFOOD PHYSICAL CHARACTERISTIC ESTIMATION SYSTEM AND METHOD - Systems and methods for estimating a physical characteristic of a seafood product are provided. In one system, the estimate is based on a slope defined by a ratio of changes in peak resonant amplitude and frequency of an electromagnetic resonant circuit in loaded and unloaded states. In another system, a first probe of a plurality of probes is driven with a test signal when the plurality of probes is loaded by a seafood product and the estimate is based on received test signals at one or more of the other probes. In another system, the estimate is based on the loading effect of a seafood product on an electromagnetic resonant circuit, which is also used to read an ID from an RFID associated with the seafood product. The systems and methods may be used for individual specimens, or to determine an average estimate for multiple specimens at one time.05-21-2009
20100030482Real-Time Swimming Monitor - A wearable device for monitoring and providing real-time feedback about a swimmer's body motion and performance, in particular, body orientation and forward speed, is provided. The device comprises a three-axis accelerometer, optionally a three-axis gyroscope, a memory, and a microcontroller configured to process the sensor input, calculate a swimmer's performance and provide feedback to the swimmer through an output. The output can be an earpiece or a swimming goggle with a digital display.02-04-2010
20100250143IDENTIFYING BIOLOGICAL RESPONSE PATHWAYS - A method for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response; accessing a database containing information characterizing molecular interactions; determining pathways connecting the identified molecules participating in the cellular response; and solving an optimization problem that includes determining a subset of the molecules and interactions having a minimum aggregate cost. The pathways include, nodes, each representing a molecule, and edges, each connecting a respective pair of nodes and representing an interaction between a respective pair of molecules represented by the respective pair of nodes. Nodes from a subset of nodes represent molecules identified as participating in the cellular response.09-30-2010
20100250144Method and System for Determining the Difference Between Pre-Prandial and Post-Prandial Blood Glucose Values - A method and system is disclosed that enables a less error-prone and preferably automatic assignment of pre-prandial and post-prandial blood glucose values associated with a meal to improve determining the difference between pre-prandial and post-prandial blood glucose measurements as follows. Blood glucose measurements are read and provided with a relative or absolute time mark and labeled as pre-prandial and reading out post-prandial blood glucose measurements provided with a relative or absolute time mark from the memory of a blood glucose measuring instrument. The chronological sequence of the blood glucose measurements labeled as pre-prandial are determined. The post-prandial blood glucose measurements that correspond to each of the pre-prandial blood glucose measurements are determined by applying a time selection criterion. The difference between corresponding pre-prandial and post-prandial blood glucose measurements is determined. The difference values are displayed that have improved diagnostic value.09-30-2010
20100250145SNP DETECTION BY MELT CURVE CLUSTERING - Systems, methods and apparatus for an automated analysis of a collection of melt curves is provided. The analysis can identify certain characteristics of double stranded nucleotide sequences (e.g. DNA or other nucleotide sequences) which were melted. For example, a variation (e.g. a mutation) in the sequences (also called amplicons) may be determined from the analysis. The amplicons may be amplified via any amplification mechanism, such as PCR or Ligase chain reaction (LCR). The automated analysis can include identifying a melt region, normalizing a melt curve, and clustering melt curves.09-30-2010
20120084015Imaging Method and Use Thereof - The present invention relates to a method based on atomic force microscopy and the use thereof on biological surfaces. A method is provided to detect the Local Deviational Volume (LDV) of defined subcellular structures irrespective of a biochemical characterisation04-05-2012
20120084010Dose Surface Method for Determination of Analyte Ratios - Methods, systems, and apparatus for accurately determining a proportion (ratio) of two analytes is provided, as well as provide a concentration of a first analyte from a determined concentration of a second analyte and from a proportion of the analytes to each other. In one aspect, a surface model (called a “dose surface” herein) relating the concentrations of the two analytes to the proportion can be used to obtain accurate values for one of the variables (e.g. a concentration or the proportion) when the other two variables have previously been obtained. The dose surface can be a three-dimensional surface and be non-linear. The dose surface model can include multiple regression functions. For example, measured responses can be individually converted to concentrations using two dose-response curves, and the concentrations can be input to a dose surface function to obtain the proportion.04-05-2012
20120084014MODELING DEVICE, PROGRAM, COMPUTER-READABLE RECORDING MEDIUM, AND METHOD OF ESTABLISHING CORRESPONDENCE - A modeling device is disclosed that easily projects characteristic information obtained from an object onto a differently-shaped object, even if the object, from which the characteristic information is obtained, has a complex shape. A modeling device in one embodiment of the present invention includes a virtually electrifying section to calculate an electric potential at a spot in a heart at the time when a predetermined voltage is applied to the heart, and a projecting section to project a fiber orientation onto a heart model created on the basis of shape information that is input to the input section. The projecting section specifies a spot to be a target of projection on the basis of the electric potential obtained by the virtually electrifying section. Use of the electric potential in specifying the spot makes it possible to easily project the fiber orientation onto any heart having complex and various shapes.04-05-2012
20120084013Software Integrated Cytometric Assay For Quantification Of The Human Polymorphonuclear Leukocyte FCyRI Receptor (CD64) - The invention relates a method of quantifying CD64 and CD163 expression in leukocytes and, specifically to a kit for use with a flow cytometer including a suspension of quantitative fluorescent microbead standards, fluorescent labeled antibodies directed to CD64 and CD163, and analytical software. The software is used to take information on the microbead suspension and fluorescent labeled antibodies from a flow cytometer and analyse data, smooth curves, calculate new parameters, provide quality control measures and notify of expiration of the assay system.04-05-2012
20120084012METHOD FOR PREDICTING ACTIVATION ENERGY USING ATOMIC FINGERPRINT DESCRIPTOR OR ATOMIC DESCRIPTOR - The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors. Specifically, the invention provides a method of predicting the activation energy either for cytochrome P450-mediated hydrogen abstraction or for tetrahedral intermediate formation in cytochrome P450-aromatic hydroxylation using equations including effective atomic descriptors.04-05-2012
20120166092BLOOD SUGAR VALUE ESTIMATION APPARATUS - The blood sugar value estimation apparatus is configured to non-invasively calculate the blood sugar value with time on the basis of the optical spectrum of the living body measured with time and the calibration model. The apparatus comprises a calibration model creating means configured to create a calibration model from the calibration models or a calibration model from a plurality of the datasets for creating the calibration model. The apparatus is configured to measure a bio-spectrum of a person being tested to set the reference spectrum, and to measure a difference spectrum of a difference between the reference spectrum and a measurement spectrum measured at a time other than a time when the reference spectrum is measured, and to change the calibration model for calculating according to the variation of the difference spectrum. Consequently, the blood sugar value is estimated, especially monitored with time, with high-accuracy.06-28-2012
20120166090Analyte Monitoring Methods and Systems - A method is disclosed involving monitoring the concentration of at least one target analyte in a sample of body fluid using a meter, the meter including a user interface, the method including: obtaining a sample of body fluid; testing the sample to determine the concentration of the at least one target analyte contained therein; and presenting the user with a reminder to associate the test with an appropriate time corresponding to before or after a particular meal using the user interface. Associated devices, systems and arrangements are also disclosed.06-28-2012
20120130648DETERMINATION OF THE RISK OF DISTANT METASTASES IN SURGICALLY TREATED PATIENTS WITH NON-SMALL CELL LUNG CANCER IN STAGE I-IIIA - A method of determination of the risk of distant metastases in surgically treated patients with non-small cell lung cancer in stage I-IIIA based on that a sample of primary tumor tissue is acquired, from which at least one microRNA is extracted which retrotranscripted into complementary DNA (cDNA) by reverse transcription, wherefore microRNA in examined sample is quantificated with the use of quantitative PCR method while the expression value of each microRNA is referred to the reference expression values in a recurrence prediction model in which the expression values are correlated to the high and low risk of distant metastases is characterized by that the expression value of only one from twenty two microRNAs listed below in Table 1 in primary tumor tissue of non-small cell lung cancer is measured.05-24-2012
20120130647SYSTEM AND METHOD FOR IDENTIFYING DISEASE-INFLUENCING GENES - A system and method for using individuals' behavioral and environmental information in conjunction with their gene sequences to find drug candidates and drug targets. Individuals designated as having a high risk for developing a particular disease are each given a remotely programmable apparatus. Queries related to the individuals' behavior and environment are sent from a server to the remotely programmable apparatuses. The individuals' responses to the queries and any physiological information are sent back to the server. The process of collecting individuals' information can take place over a period of time to ensure accurate data and to allow researchers to observe progression of the disease. A data mining program on the server analyzes the individuals' behavioral and environmental information, as well as their gene sequences.05-24-2012
20120130646ANALYTE TESTING METHOD AND SYSTEM WITH HIGH AND LOW ANALYTE TRENDS NOTIFICATION - Described herein are systems and methods to utilize factual information based on stored analyte data to allow greater insight into a chronic disease of a user, such as, for example a diabetic patient.05-24-2012
20120130645METHOD AND APPARATUS FOR MEASURING BODY IMPEDANCE BASED ON BASEBAND SIGNAL DETECTION - Certain aspects of the present disclosure relate to techniques for measuring body impedance based on baseband signal detection in analog domain. Proposed methods and apparatus are able to measure an impedance of human body based on sub-Nyquist sampling of signals. The proposed techniques can be particularly beneficial for reducing overall sensor power when an actuation signal generates electrical signals corresponding to vital signs in humans.05-24-2012
20120166091METHOD AND APPARATUS FOR ANALYZING GAIT PATTERN - A method and apparatus for recognizing a gait pattern are provided. The method for recognizing a gate pattern includes: obtaining a walker's foot pressure distribution values through a pressure sensor array disposed at the bottom of a pair of shoes; calculating valid pressure points among the foot pressure distribution values; calculating a center of pressure (COP) movement trace by using the valid pressure points; and recognizing the walker's gait pattern by using the COP movement trace.06-28-2012
20100082262HAPLOTYPE ESTIMATING APPARATUS AND PROGRAM - The present invention calculates a sum of the count numbers for each of the marker sites to obtain a maximum value of the sum of the count numbers, enumerates polymorphic identification characters up to the count numbers of the polymorphic nucleotides, permutates the enumerated polymorphic identification characters so as to create any character string that has copy units of which the number equals the maximum value, divides the character string into two by the copy unit to store the divided strings as a combination of the haplotype character strings, calculates the number of identical haplotype character strings in the group, obtains a frequency of the haplotype character string in the group, and estimates the combination of the haplotype character strings (representing haplotypes) of each individual of which frequency satisfying a predetermined condition.04-01-2010
20120316793METHODS AND SYSTEMS FOR INDICATING BEHAVIOR IN A POPULATION COHORT - Avatars, methods, apparatuses, computer program products, devices and systems are described that carry out identifying a member of a population cohort; and indicating at least one behavior in the member of the population cohort based on an association between the population cohort and at least one cohort-linked avatar.12-13-2012
20120215462SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA - Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.08-23-2012
20120215461SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA - Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.08-23-2012
20120215455System and Method for Medical Diagnosis Using Geospatial Location Data Integrated with Biomedical Sensor Information - In at least one embodiment, a method and system for accumulating geospatial location data and biomedical data for an individual during his/her travels is provided. In at least one embodiment, a device uses at least one location signal to determine geospatial data and receives a plurality of biomedical signals with both data types being stored for possible later retrieval for providing a diagnosis for the individual if a medical condition arises. An embodiment of the invention provides a method of operation of a device having at least a memory and a communications module where the method includes receiving at least one location signal with the communications module; storing geospatial data obtained at least from the at least one location signal with a time stamp in memory; receiving a plurality of biomedical signals over time from at least one sensor with the communications module; storing biomedical data from the received biomedical signal with a time stamp in memory; and repeating the receiving at least one location signal and storing geospatial data from the at least one location signal in different geographic locations.08-23-2012
20120215458Orthologous Phenotypes and Non-Obvious Human Disease Models - A method for the quantification of equivalence between mutational phenotypes to develop non-obvious human disease models is described herein. The present inventors discover candidate genes for diseases of interest by: first, identifying orthologous phenotypes (called phenologs) involving the phenotype of interest (the first phenotype), in which a set of genes is associated with the first phenotype in the first organism, a set of genes is associated with a second phenotype in a second organism, the first and second phenotypes not having one or more common characteristics, and the second phenotype is selected such that at least one gene belongs to both the first and second phenotype gene sets; second, selecting from the second organism one or more second phenotype genes, other than the genes known to overlap the first and second phenotypes, as candidates for also belonging to the first phenotype in the first organism.08-23-2012
20120215457METHODS AND SYSTEMS TO ANALYZE REACTIONS USING AN INFORMATION SYSTEM - Disclosed are example methods and systems to determine the quantity of an analyte initially present in a chemical and or biological reaction. Also disclosed are computer implemented methods and systems to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.08-23-2012
20120215456SYSTEM AND METHOD FOR CELLULAR OPTICAL WAVEFRONT SENSING - An optical system for non-invasive cytometry of mammalian cells includes a light source, a cell positioner, an optical imager, an optical wavefront sensor and a computer. The light source produces an illuminating beam of spatially coherent radiation. The cell positioner sequentially moves a single cell from a population of multiple cells into a sub-aperture region of the illumination beam whose wavefront is perturbed in response to the physical structure of the single cell. An optical system relays a magnified image of the sub-aperture region containing the cell to an image plane. At the image plane a Shack-Hartmann wavefront sensor is positioned. Within the pupil of the wavefront sensor the local tilts of the wavefront in the sub-aperture region are measured and sent to a computer. Software calculates the Zernike coefficients corresponding to the aberration induced by the structure of each cell. Their Zernike signatures classify the cells into distinct types.08-23-2012
20120215454Adaptive lightweight acoustic signal classification for physiological monitoring - The present invention provides adaptive lightweight acoustic signal classification for physiological monitoring applications. In an exemplary implementation, the total energy of a segment of an acoustic signal recording body sounds is first determined. For each of a plurality of signal classes (e.g., good, noisy, weak), the probability that the segment belongs to the signal class is then calculated using the total energy and profile data for the signal class. The segment is then assigned to one of the plurality of signal classes by reference to the probabilities. Physiological data are then selectively generated and outputted using the segment, depending on the assigned signal class, and the segment is selectively applied as feedback to update profile data for the assigned signal class.08-23-2012
20100204922METHOD AND APPARATUS FOR SELECTING PHARMACOGENOMIC MARKERS - Provided are a method and apparatus for selecting pharmacogenomic markers. The method includes calculating evaluation indexes for evaluating the degree of association between genetic markers of genes associated with at least one drug and the drug, and selecting some of the genetic markers based on the calculated evaluation indexes.08-12-2010
20100204921METHOD FOR SELECTING STATISTICALLY VALIDATED CANDIDATE GENES - Provided herein are methods for evaluating associations between candidate genes and a trait of interest in a population. The methods include a combination of genome-wide association analysis and one or more of nested association mapping (NAM), expression QTL analysis (eQTL), and allele epistastic analysis (AEA). Markers are selected or prioritized if they are shown to be positively-correlated with a trait of interest using GWA and a combination of one or both of NAM and eQTL. Also provided are models for evaluating the association between a candidate marker and a trait in a nested population of organisms. These methods include single marker regression and multiple marker regression models. Markers identified using the methods of the invention can be used in marker assisted breeding and selection, as genetic markers for constructing linkage maps, for gene discovery, for identifying genes contributing to a trait of interest, and for generating transgenic organisms having a desired trait.08-12-2010
20100204920SYSTEM FOR DEVELOPMENT OF INDIVIDUALISED TREATMENT REGIMENS - A system is provided for facilitating the development of an individualised treatment regimen for a patient based on an evaluation of the risk(s) associated with a disease and/or associated with known treatment options. In order to evaluate these risk(s), the system utilises clinical data from a plurality of patients having the disease in question. The clinical data includes information for each of the plurality of patients relating to the presence, absence and/or severity of one or more negative events. The negative event(s) can be disease-related, for example, a complication such as metastasis of a cancer to bone or the brain, or the negative event(s) can be treatment-related, for example a toxicity associated with the treatment. The system can also include prediction models that allow the probability that a patient will develop a toxicity or complication to be assessed. Methods for developing prediction models are provided.08-12-2010
20100204923Comparing Accuracies Of Lie Detection Methods - A method for selecting the most accurate lie detection method from a group of methods, the method includes the steps of: (a) collecting the results from different methods of conducting lie detection tests; (b) plotting the results on a polar graph; c) computing the “random chance” point on the graph for each method's results; (d) fitting a quadratic curve to the defined points for each method; (e) computing the area beneath each method's curve; (f) mapping the area to a log-base-2 score; and (g) choosing as the most accurate method the method with a higher log-base-2 score.08-12-2010
20120136583METHOD FOR PREDICTING EFFICACY OF DRUGS IN A PATIENT - The present invention concerns a method for predicting the relative efficacy of a plurality of drugs for treating a tumour in an individual comprising the molecular characterization of the tumour, and the calculation of a score for the plurality of drug essentially based on the percentage of deregulated target gene.05-31-2012
20120136580System and Method for Analyzing an Electrophysiological Signal - A system and a method of analyzing an electrophysiological signal, wherein the system comprises an acquisition device for acquiring a test electrophysiological signal associated with an anatomical part of a patient and a processor configured to divide a cycle of the test electrophysiological signal into test time windows, compare a test signal value of each of the test time windows with a reference signal value of reference time windows of the reference segments of respective representations representing respective predetermined morphological classes to obtain a difference, define grid points associated with respective test time windows, respective reference time windows and respective differences, obtain a warping path using the grid points non-linearly in a predetermined order, sum differences along the grid points of each of the warping paths to obtain a cumulative distance for each of the warping paths, and classify the test electrophysiological signal into one of the respective predetermined morphological classes corresponding to the warping path of the respective representation having the least cumulative distance.05-31-2012
20120136582MEASURING HEMATOCRIT AND ESTIMATING HEMOGLOBIN VALUES WITH A NON-INVASIVE, OPTICAL BLOOD MONITORING SYSTEM - An optical blood monitoring system with a ratiometric model determines hematocrit values for a hemodialysis patient, from which hemoglobin values for the patient are estimated. The ratiometric model is calibrated, normally against a cell counter, using blood from a blood bank. The blood from a blood bank is preserved in a long term preservative which is typically different than that found in clinical settings. The hematocrit value determined by the ratiometric model is scaled by scaling factor so that the estimated hemoglobin level output from the monitor consistently matches that measured in a clinical setting. The hematocrit scaling factor is substantially about 1.033 when the patient's blood sample is stored in a short term preservative ethylene diamine tetra acetic, and is substantially about 1.06 when the hematocrit is measured in the blood sample without preservative being added to the blood sample. The hemoglobin value can also be adjusted for altitude.05-31-2012
20110184653ANALYTE TESTING METHOD AND SYSTEM - Various methods and systems to manage diabetes using data relating to testing compliance, bolus dosing, or cannula usage are described and illustrated.07-28-2011
20110184656Efficiently Determining Condition Relevant Modifiable Lifestyle Attributes - A bioinformatics method, software, system and database are presented in which attribute profiles containing pangenetic and non-pangenetic information are created and used to identify sets of attributes, including lifestyle attributes that are associated with a condition. The lifestyle attributes which can be modified and which result in a significant change in the probability of having the condition are identified and used as the basis for recommendations for lifestyle modification.07-28-2011
20110184655NUMBER CODING FOR IDENTIFICATION OF SUBTYPES OF CODED TYPES OF SOLID PHASE CARRIERS - Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers which provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the bases of a different code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, to determine whether a sample is homozygous or heterozygous at a number of different sites for one of two different alleles, where the same color code is applied for each of the two alleles, and the alleles with the same color code are distinguished by knowing how many carriers are associated with molecules which detect each different allele.07-28-2011
20110184654Means and Methods for Detecting Bacteria in an Aerosol Sample - This disclosure provides a method for detecting and/or identifying uncultured bacteria. The sample is an aerosol sample selected from a group consisting of cough, sneeze, saliva, mucus, bile, urine, vaginal secretions, middle ear aspirate, pus, pleural effusions, synovial fluid, abscesses, cavity swabs, serum, blood and spinal fluid. The method comprises obtaining absorption spectra (AS) of the sample, extracting and processing the acquired data, thereby detecting and/or identifying the bacteria.07-28-2011
20110184652METHODS OF GENERATING GENETIC PREDICTORS EMPLOYING DNA MARKERS AND QUANTITATIVE TRAIT DATA - A genetic trait predictor is generated by blending individual molecular estimates with estimates of at least one genetic value derived from quantitative trait measure. The individual molecular estimates may include molecular trait estimates or molecular trait variance. The individual molecular estimates may be determined by applying individual deoxyribonucleic acid (DNA) markers, DNA marker panels, specific parameter estimates and specific parameter variance thereof, and a genotype of a test sample. Quantitative trait measure may include estimated breeding data, raw trait data, and breed composition data. The genetic predictor is accurate and stable under a wide range of conditions and relatively immune to errors in parameter estimation.07-28-2011
20110184651ELECTRONIC ASSAY APPARATUS AND METHOD THEREOF - The present invention related to an electronic assay apparatus and a testing method thereof for increasing efficiency and saving power. The electronic assay apparatus for determining a result of an assay performed using a test strip comprises two light sources, one detector and a microprocessor. The two light sources respectively illuminate light incident upon a test zone or a control zone of a test strip. The only one detector disposed between the two light sources and detects light reflected from the test zone and the control zone alternately. The microprocessor compares a calculating result value to only one threshold for showing a result.07-28-2011
20110184650UTILITY AND METHOD FOR THE APPLICATION OF SIGNAL ADVANCE AMPLIFICATION TO ANALOG WAVEFORM OR SIGNAL DETECTION, ACQUISITION AND PROCESSING - An analog waveform signal detection/data acquisition system that is based on negative group delay for reducing inherent delay in analog waveform or signal detection and acquisition and facilitating earlier than otherwise possible responsive actions to analog waveform data. Signal advance amplification and data conditioning reduces distortion and permits greater temporal advance than previously possible.07-28-2011
20110184648METHODS AND APPARATUS FOR PERFORMING RETENTION-TIME MATCHING - A method for matching a precursor ion with one or more related product ions includes providing input data sets obtained from sample injections, each of the data sets including a precursor ion and one or more product ions, normalizing the input data sets in accordance with a single retention time for the precursor ion, determining which product ions are within a predetermined retention time window with respect to the single retention time, and, if a product ion is within the predetermined retention time window for a specified number of the input data sets, determining that the product ion is related to the precursor having the single retention time. An apparatus for analyzing a sample includes a chromatography module, a mass-spectrometry module in communication with the chromatography module, and a control unit in communication with the chromatography module and the mass-spectrometry module.07-28-2011
20100174492Method and system for determining whether a drug will be effective on a patient with a disease - A process of determining whether a patient with a disease or disorder will be responsive to a drug, used to treat the disease or disorder, including obtaining a test spectrum produced by a mass spectrometer from a serum produced from the patient. The test spectrum may be processed to determine a relation to a group of class labeled spectra produced from respective serum from other patients having the or similar clinical stage same disease or disorder and known to have responded or not responded to the drug. Based on the relation of the test spectrum to the group of class labeled spectra, a determination may be made as to whether the patient will be responsive to the drug.07-08-2010
20100174491METHODS OF MEASURING CONCENTRATION OF COMPONENT IN BIOCHEMICAL SAMPLE AND ESTIMATING RELIABILITY OF TEST RESULT - Provided are a method of measuring a concentration of a component in a biochemical sample such as serum, and a method of estimating the reliability of a test result using the method. The method of measuring a concentration of a component includes: preparing plural standard samples having at least one common component which has varying concentrations; measuring absorbances of the component in the standard samples at each of the concentrations for plural light beams having different wavelength bands; determining a regression equation of a relationship between the concentration of the component and the measured absorbances at plural wavelength bands; and applying the regression equation by measuring absorbances at the plural wavelength bands of the biochemical sample and applying the measured plural absorbances of the biochemical sample to the regression equation to calculate the concentration of the component.07-08-2010
20100174493Systems for genome selection - Systems, methods, compositions and apparatus relating to genome selection are disclosed.07-08-2010
20120173156METHOD AND SYSTEM FOR CURVE QUALITY CONTROL - A method of analysis wherein molecular interactions at one or more sensing surface areas are detected and respective response curves representing the progress of each interaction with time are produced, and wherein a resulting set of response curves is subjected to a quality assessment procedure which comprises representing the response curves with one or more quality descriptors, applying a quality classification method to the descriptors to find outliers, and removing the outliers. The invention also relates to an analytical system including means for classifying the response curves with regard to quality, a computer program for performing the classification, and a computer program product containing the program.07-05-2012
20120173155NETWORK THREADING APPROACH FOR PREDICTING A PATIENT'S RESPONSE TO HEPATITIS C VIRUS THERAPY - The present invention generally relates to a computer-implemented method for predicting a response of a virus to antiviral therapy, and finds particular use in predicting a response of a Hepatitis C or Hepatitis B virus isolated from a patient.07-05-2012
20120173154OXIDATIVE STRESS MEASUREMENT DEVICE AND RELATED METHODS - For measuring an oxidative stress component in a patient, an optical analyzer having a light source and a light detector is used for measuring an optical property of a medium and generating optical measurement data. A processor analyzes the optical measurement data and generates a value for one or more oxidative stress component in the form of a redox signature for the patient. Probability data of the presence of an oxidative stress dependent disease can be calculated. By observing at least one additional clinical condition of the disease, a diagnosis using said at least one additional condition and said redox signature can be obtained.07-05-2012
20120173153DATA ANALYSIS OF DNA SEQUENCES - Systems and methods for data analysis are provided. In one embodiment, a method may be provided for analysis comprising electronically receiving sequence data related to a plurality of sequences and a reference sequence, associating the sequence data with one of at least two groups, identifying a plurality of high quality read sequences from among the plurality of sequences, extracting a plurality of unique read sequences from the plurality of high quality read sequences, and aligning the plurality of unique read sequences against the reference sequence data corresponding to a reference sample. The method may further identify mutations in a targeted location, display the targeted mutations, and prioritize the technologies that caused the mutations according to their efficiency. In one example, the systems and methods are used to characterize the activity of several ZFN candidates.07-05-2012
20120173152GLUCOSE MANAGEMENT DEVICE AND METHOD OF USING THE SAME - A glucose management device and method of managing glucose using the same. The glucose management device has a housing with an input device and receives a vitro test element that determines a user's glucose level. Glucose measurement circuitry is electrically connected to the vitro test element to communicate data received from the vitro test element to a processor. The processor then prompts a user to input user information regarding units of insulin taken, other medication taken, and activity level into the input device so that the processor records the information for later downloading.07-05-2012
20120173151METHODS OF ASSESSING DIABETES TREATMENT PROTOCOLS BASED ON PROTOCOL COMPLEXITY LEVELS AND PATIENT PROFICIENCY LEVELS - Embodiments of methods of assessing a diabetes treatment protocol comprise determining a protocol complexity level corresponding to a degree of difficulty of completing the diabetes treatment protocol by utilizing the processor, determining a patient proficiency level corresponding to a skill set of the patient in conducting the diabetes treatment protocol by utilizing the processor, comparing the protocol complexity level to the patient proficiency level via the processor, and providing an output based on the comparison.07-05-2012
20120221249Long Hepitype Distribution (LHD) - The invention includes a method of creating a sequence information framework that defines the range of epigenetic configurations of individual DNA strands in any diploid organism in which DNA methylation is prevalent. The invention also includes a method of generating DNA descriptors referred to as long hepitype distributions (LHDs).08-30-2012
20120215460Temperature-Adjusted Analyte Determination For Biosensor Systems - A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.08-23-2012
20120221253DEVICES AND METHODS FOR MONITORING, MANAGING, AND SERVICING MEDICAL DEVICES - A method and apparatus for billing entities for use of a medical device, which relates to the processing of regenerative cells to facilitate at least one of hard and soft tissue formation, are described. When an operator uses the medical device, a corresponding charge is determined. Billing for usage of the medical device is performed on a periodic or per-use basis. Communication over a network facilitates remote management and servicing of the medical device. Support is provided for automatic ordering of supplies consumed by the medical device.08-30-2012
20120221251SYSTEMS AND METHODS FOR SELECTING, ORDERING, SCHEDULING, ADMINISTERING, STORING, INTERPRETING AND TRANSMITTING A PLURALITY OF PSYCHOLOGICAL, NEUROBEHAVIORAL AND NEUROBIOLOGICAL TESTS - A system comprises a validation module and an analysis module. The validation module is configured to receive input data from an electronic device operated by a test-taker during a biopsychosocial assessment. The input data includes a plurality of input terms that describes a functioning of the test-taker. The validation module is configured to validate the plurality of input terms based on a plurality of pre-defined terms stored within the system. The analysis module is configured to generate a list of potential biopsychosocial-related issues associated with the test-taker based on the validated input terms, and to generate a recommendation of one or more tests to administer to the test-taker based on this list. The analysis module is further configured to transmit an output signal representing the recommendation to an electronic device such that the one or more recommended tests are presented at an electronic device.08-30-2012
20120221254DATA COLLECTION UNIT WITH INTEGRATED CLOSURE SYSTEM AND SENSOR HOUSING - A physical activity data collection unit includes one or more infrared sensors configured to provide an output indicative of a pulse rate of a user of the physical activity data collection unit, at least one temperature sensor configured to provide an output indicative of at least a body temperature of the user, and at least one accelerometer configured to provide an output indicative of movements of the user. The physical activity data collection unit can also include a microcontroller configured to determine a pulse rate, a body temperature, and movement characteristics of the user of the data collection unit based on outputs from the one or more infrared sensors, the at least one temperature sensor, and the at least one accelerometer; determine a physical exertion level of the user based on one or more of the pulse rate, the body temperature, or the movement characteristics of the user; and store, in a memory, data indicative of the physical exertion level during a time period during which the physical exertion level exceeds a predetermined threshold. The physical activity data collection unit can also include a closure system configured to secure the data collection unit to a wrist of the user.08-30-2012
20120221252SYSTEMS AND METHODS FOR DISTINGUISHING OPTICAL SIGNALS OF DIFFERENT MODULATION FREQUENCIES IN AN OPTICAL SIGNAL DETECTOR - Systems and method for detecting optical signals, and for discriminating optical signals emitted by an emission moiety that is excited by an associated excitation signal from background signals and other optical noise, employing digital techniques for determining the portion of a detected optical signal having a modulation frequency corresponding to a modulation of the associated excitation signal.08-30-2012
20100057369Corrective methodology for processing results of transcriptome experiments obtained by differential analysis - A corrective method for processing results of transcriptome experiments obtained by differential analysis includes the following steps: 03-04-2010
20120221250SYSTEM AND METHOD FOR MONITORING THE FEEDING PRACTICES OF INDIVIDUAL ANIMALS IN A GRAZING ENVIRONMENT - There is disclosed a method for the management of animals grazing in a pasture, comprising feeding a marker labelled supplement to grazing animals. Monitoring consumption of said marker labelled supplement by said animals to generate supplement consumption data for said animals. Measuring physical characteristics of said animals to generate physical characteristic data for said animals. Collecting faecal samples from said animals. Analysing said faecal samples, samples of said pasture and said supplement to generate faecal data, pasture data and supplement data and processing Said supplement consumption data, said physical characteristic data and said fecal data, pasture data and supplement data to determine individual animal diet and nutritional information for animal management purposes.08-30-2012
20120215459HIGH THROUGHPUT DETECTION OF GENOMIC COPY NUMBER VARIATIONS - The invention relates to methods and algorithms for detecting and analysis of copy number variances in a genetic segment. The invention also relates to a computer implemented sequential method of processing and interpreting experimental data generated by genotyping nucleic acid-chips or nucleic acid-beads based on detection of a hybridization signal.08-23-2012
20100049445METHOD AND APPARATUS FOR SEQUENCING DATA SAMPLES - A method for identifying non-host nucleic acid sequence using sequence data. The method of identifying non-host nucleic acid can include sequencing a sample into sequences and associating the sequences with a host genome and then exclude any sequences that are associated with the host genome. The method can then associate the sequences with any known genomes and exclude any sequences that are associated with any known genome. The remaining sequences can be used as seed sequences to assemble a non-host nucleic acid.02-25-2010
20100049448MULTIDIMENSIONAL MORPHOLOGICAL RECONSTRUCTION OF GENOME EXPRESSION ACTIVITY - A method of morphological reconstruction of biological activity in a tissue sample maps biological data resulting from analysis of tissue samples onto a 3-D morphological rendering of the biological sample. Each slice in a set of histological slices, indexed by a first index, is micro dissected into micro samples indexed by a pair of first and second indices. The indices are utilized to spatially map biological data to the 3-D rendering.02-25-2010
20100049447Method of modeling the behavior of an eye subjected to an external force - A method for simulating the behavior of an eye comprising the steps of (i) generating a FEM model of the eye representing the physical structure of the eye, the FEM model including an elastic walled corneo-scleral shell, (ii) modeling deformations of the eye with the FEM model, the deformation modeling including the simulated application of at least one external force to the FEM model, and (iv) obtaining FEM model solutions iteratively in an incremental fashion, whereby adjustable nodal pressure is introduced inside the corneo-scleral shell.02-25-2010
20100049446GENE CLASSIFYING METHOD, GENE CLASSIFYING PROGRAM, AND GENE CLASSIFYING DEVICE - A gene classifying method is provided and includes acquiring expression levels of a plurality of genes at a plurality of observation points, generating a binary string by taking a positive or negative difference in expression level in a temporal passage direction of the observation points for each gene, and classifying the genes on the basis of all plus and minus patterns that the binary strings can have and the generated binary strings.02-25-2010
20100049444CALIBRATION SURFACE METHOD FOR DETERMINATION OF ANALYTE RATIOS - The ratio of analytes is determined directly from the responses of the analytes using a conversion method. Individual analyte responses are obtained by using a selected measuring technique, and these individual responses are used as the independent variables in a conversion method. The dependent variable of conversion method is the desired analyte ratio. The resulting conversion method is then used to directly calculate the desired ratio of analytes as a function of the measured responses. No intermediate conversions, such as using a calibration curve to convert individual measured analyte responses to concentration values, are needed to obtain the desired ratio.02-25-2010
20100299075SYSTEMS AND METHODS FOR CALCULATING AN AVERAGE ANALYTE CONCENTRATION VALUE - Embodiments provide methods and systems wherein analyte concentration readings taken over a first period of time are collected and processed to determine one or more analyte concentration averages. The methods include collecting samples with a measurement system (e.g., a Blood Glucose Meter) over a first period of time, dividing the first period of time into smaller time increments, and calculating an average analyte concentration based on first sub-averages obtained from each of the smaller time increments. Systems for carrying out the analyte concentration averages are described, as are other aspects.11-25-2010
20100299074REMOTE DATA COLLECTING SYSTEMS AND METHODS - The present invention provides a remote data collecting system comprising a measuring device comprising at least two scales in communication with a terminal center. The terminal center is in communication with a control center. The control center can be linked to a computer with software to collect, distribute, analyze, and display data collected from the measuring device. The remote data collecting system is particularly useful for uncontrolled environment (e.g., in-home) product testing such as testing the palatability of pet foods.11-25-2010
20100299072SUBSTRATE CONCENTRATION MEASUREMENT METHOD AND SUBSTRATE CONCENTRATION MEASUREMENT APPARATUS - This invention is a method for a substrate concentration measurement method including measuring a concentration of a substrate in a blood specimen containing hemoglobin. In the method, the substrate concentration is calculated by using a measurement value correlating with a substrate concentration influenced by hemoglobin, and a hemoglobin concentration or a value correlating with the hemoglobin concentration. A substrate concentration is calculated by correcting the measurement value Re correlating with the substrate concentration based on the following Formulae 1 and 2: [Formula 1] Corrected value=100×Re/V (%), wherein V (%) represents a value with respect to plasma (a ratio of a measurement value influenced by hemoglobin with respect to a measurement value obtained by measuring plasma), and Re represents the measurement value correlating with the substrate concentration influenced by hemoglobin; [Formula 2] Value with respect to plasma V (%)=(Vmax×Re)/(Km+Re)+B, wherein Vmax represents a value obtained by subtracting an intercept (B) from the value (V) with respect to plasma which is maintained constant even when the measurement value influenced by hemoglobin increases, Km represents a value of Re at which the value V (%) with respect to plasma becomes Vmax/2, and B represents a value (constant) of V (%) with respect to plasma when Re is 0.11-25-2010
20120179385TRAJECTORY CREATING APPARATUS - A trajectory creating unit uses sensor values obtained from an acceleration sensor and an angular velocity sensor that are attached to a predetermined region of a person's body and creates a motion trajectory of the predetermined region. The trajectory creating unit separately creates a motion trajectory of a predetermined region of the person's body obtained between the starting motion of the series of the movements and an impact motion, and a motion trajectory of the predetermined region of the body obtained between the impact motion and the end motion of the movements.07-12-2012
20120179384METHOD FOR ANALYZING NUCLEIC ACID MUTATION USING ARRAY COMPARATIVE GENOMIC HYBRIDIZATION TECHNIQUE - There is provided a method for analyzing nucleic acid mutation using an array comparative genomic hybridization technique, which reduces the false positive and the false negative and improves the reliability of the analysis results. A method for analyzing nucleic acid mutation using array comparative genomic hybridization technique comprising: [(a) a step of bringing a plurality of labeled sample nucleic acids one by one into contact with the plural same probe nucleic acid sets], [(b) a step of obtaining label intensities], [(c) a step of determining whether each piece of comparison values falls within a prescribed numerical value range or not], and [(d) a step of comparing whether the number of the comparison values exceeds a prescribed number or not and, in the case of exceeding the prescribed number, judging the spot positive].07-12-2012
20120179383DISC AND CALIBRATION METHOD OF TEST DEVICE USING THE SAME - A disc for calibrating a measurement unit of a test device and a calibration method using the same are provided. The disc includes a calibration unit to calibrate a measurement unit of a biomaterial test device.07-12-2012
20120179382System for Ventricular Arrhythmia Detection and Characterization - A system for heart performance characterization and abnormality detection detects peaks and at least one of, a valley and a baseline comprising a substantially zero voltage level, of received signal data representing oxygen content of blood in a patient vessel over multiple heart beat cycles. The signal processor determines signal parameters including at least one of, (a) a signal amplitude magnitude between a maximum peak and minimum valley, of the received signal data, (b) a signal amplitude magnitude between a maximum peak and a baseline, of the received signal data and (c) a signal amplitude magnitude between a second highest maximum peak and minimum valley, of the received signal data. The system compares a determined signal parameter or value derived from the determined signal parameter, with a threshold value and generates an alert message associated with the threshold, in response to the comparison.07-12-2012
20120179381TOXICITY SCREENING METHODS - In vitro methods for predicting in vivo toxicity of chemical compounds, including organ-specific and multiple organ toxicity of such chemical compounds and drug-drug interactions, understanding the relative toxicity of drug candidates and identifying mechanisms of toxicity, are disclosed.07-12-2012
20120179380MEASUREMENT APPARATUS AND METHOD THEREFOR - A measurement apparatus comprises a probe system (07-12-2012
20100274500METHOD AND SYSTEM FOR MEASURING MEMBRANE POTENTIAL BASED ON FLUORESCENCE POLARIZATION - A method of determining a membrane potential is disclosed. The method comprises (a) determining a difference in fluorescence polarization of a charged fluorescent probe being distributed across the membrane; and (b) determining a potential of the membrane, wherein the potential is proportional to the difference in the fluorescent polarization.10-28-2010
20100274498INFORMATION PROVIDING SYSTEM AND ANALYZER - An information providing system comprises an analyzer and an information server communicatively connected to the analyzer through a network, which stores coping information regarding apparatus abnormalities of the analyzer, and the analyzer obtains the coping information corresponding to the apparatus abnormalities that occur to the analyzer from the information server, and displays this coping information on a display unit.10-28-2010
20100274495NOVEL CLINICAL TRIAL METHODS TO IMPROVE DRUG DEVELOPMENT FOR DISEASE THERAPY AND PREVENTION - In one embodiment, a method for a multiplexed continuous biomarker clinical trial is disclosed that evaluates multiple drugs concurrently or subsequently against a continuously collected and enlarging control group with increasing statistical power.10-28-2010
20100274494BIOEQUIVALENCE EVALUATION METHOD OF EVALUATING BIOEQUIVALENCE OF A GENERIC DRUG TO THE CORRESPONDING ORIGINAL DRUG10-28-2010
20100017140METHODS FOR ANALYSIS OF MicroRNA - The present invention concerns a method for identifying the functionality of each member of a family of nucleic acids interact with the first family. Nucleic acids from the first family are put into functionally related clusters that share biological information obtained from the second family. The invention also relates to the refinement and accurate prediction of interactions between the first family and the second family of nucleic acids. The invention also applies to the use of such functional information to identify targets and mechanisms for therapeutic applications.01-21-2010
20100010748Method and system for DNA analysis - The present invention pertains to a process for automatically analyzing nucleic acid samples. Specifically, the process comprises the steps of forming electrophoretic data of DNA samples with DNA ladders; comparing these data; transforming the coordinates of the DNA sample's data into DNA length coordinates; and analyzing the DNA sample in length coordinates. This analysis is useful for automating fragment analysis and quality assessment. The automation enables a business model based on usage, since it replaces (rather than assists) labor. This analysis also provides a mechanism whereby data generated on different instruments can be confidently compared. Genetic applications of this invention include gene discovery, genetic diagnosis, and drug discovery. Forensic applications include identifying people and their relatives, catching perpetrators, analyzing DNA mixtures, and exonerating innocent suspects.01-14-2010
20100010746Sample analyzer, method for displaying analysis result information of a sample and computer program product - The present invention is to present a sample analyzer comprising: an analysis result information generator for generating analysis result information including an analysis result of a sample; a display; a display controller for controlling the display so as to display the analysis result information generated by the analysis result information generator; an input receiver for receiving an input of a comment to one of the analysis result information; a memory for storing the comment received by the input receiver; and a determiner for determining whether another analysis result information to be displayed on the display meets with a predetermined condition, wherein the display controller controls the display so as to display the another analysis result information and the comment stored in the memory, when the determiner has determined that the another analysis result information meets with the predetermined condition.01-14-2010
20120253687METHOD FOR ANALYZING RNA - A method of analyzing RNA extracted from a tissue or cell(s) fixed with a fixative, said method comprising a determining step of whether said RNA satisfies: B/A≦1 wherein A represents the weight ratio (%) of RNA within the range of 1000 to 4000 nucleotides with respect to the total weight of RNA as determined by electrophoresis; and B represents the weight ratio (%) of RNA within the range of more than 4000 nucleotides with respect to the total weight of RNA as determined by electrophoresis.10-04-2012
20120253688System, Method, and Computer Product for Exon Array Analysis - In one embodiment, a method for analyzing data generated by probe arrays is described that comprises receiving user selections of two or more data files and an identification of one or more subsets of intensity values acquired from a biological probe array. The method includes iteratively opening each data file, identifying the selected subset of intensity values associated with each open data file, determining parameters for processing, storing the parameters and the identified intensity values, and closing the open data file prior to the subsequent iteration. The method then includes processing the stored intensity values using the parameters to identify one or more biological events.10-04-2012
20120253686SYSTEM AND METHOD FOR MULTIPLE-FACTOR SELECTION - The disclosed subject matter provides techniques for multiple-factor selection. The factors can be features or elements that are jointly associated with one or more outcomes by their joint presence or absence. There may be a non-causative correlation between the factors, features, or elements and the outcomes. In some embodiments, Entropy Minimization and Boolean Parsimony (EMBP) is used to identify modules of genes jointly associated with disease from gene expression data, and a logic function is provided to connect the combined expression levels in each gene module with the presence of disease. The smallest module of genes whose joint expression levels can predict the presence of disease can be identified.10-04-2012
20120253684METHODS AND APPARATUS FOR PERFORMING RETENTION-TIME MATCHING - A method for matching a precursor ion with one or more related product ions includes providing input data sets obtained from sample injections, each of the data sets including a precursor ion and one or more product ions, normalizing the input data sets in accordance with a single retention time for the precursor ion, determining which product ions are within a predetermined retention time window with respect to the single retention time, and, if a product ion is within the predetermined retention time window for a specified number of the input data sets, determining that the product ion is related to the precursor having the single retention time. An apparatus for analyzing a sample includes a chromatography module, a mass-spectrometry module in communication with the chromatography module, and control unit in communication with the chromatography module and the mass-spectrometry module.10-04-2012
20100292931OPTICAL PLATFORM FOR SIMULTANEOUSLY STIMULATING, MANIPULATING, AND PROBING MULTIPLE LIVING CELLS IN COMPLEX BIOLOGICAL SYSTEMS - An optical platform and system for the simultaneous stimulation, manipulation and probing of multiple living cells in complex biological systems. The apparatus utilizes a spatiotemporal light modulator to expose a sample to pinpoints of light at selected times and wavelengths in two or three dimensional space and then detect the responses. In one embodiment, a spatiotemporal light modulator is optically coupled to a variable wavelength light source, a lens system and a system control unit with sample response sensors, wherein sample responses are detected after exposure to patterns of light in real time. Light patterns can be modulated in response to sample responses.11-18-2010
20100070191Lung Cancer Biomarkers and Uses Thereof - The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, Col. 2, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.03-18-2010
20090319193METHODS, SYSTEMS, ALGORITHYMS AND MEANS FOR DESCRIBING THE POSSIBLE CONFORMATIONS OF ACTUAL AND THEORETICAL PROTEINS AND FOR EVALUATING ACTUAL AND THEORETICAL PROTEINS WITH RESPECT TO FOLDING, OVERALL SHAPE AND STRUCTURAL MOTIFS - Methods, systems, algorithms and means for describing, analyzing and predicting protein folding motifs and other structures are provided. In one aspect, the Protein Folding Shape Code (PFSC) methods, systems, algorithms and means of the present invention apply generally to all of the categories of protein analysis and description, and are especially relevant to the geometric analyses and descriptions of proteins from their respective sequences or sequence portions. In a novel approach, the present inventions render analyses with respect to the alpha carbons of five-amino acid elements of a protein, utilizing available data to derive torsion angles and pitch distances, to thereby generate a series of overlapping analyses that can be expressed by a plurality of 27 vectors. Methods, systems and algorithms of the invention can be embodied in any computing device or portion thereof, and are adaptable to describe, analyze and predict the folding and other three-dimensional aspects of the structures of biomolecules such as nucleic acids, carbohydrates and glycoproteins. As yet another advantage, the present invention is adaptable as a tool for describing the conformations of many other organic molecules, and are thus especially suitable for use in the design of drugs, and the discovery and design of molecules which are to be adapted to interact with drugs.12-24-2009
20120316794METHOD AND A SYSTEM FOR MONITORING A PHYSIOLOGICAL PARAMETER OF A SUBJECT - Embodiments provide a method which includes transmitting, by a receiving device (RD), a request message which includes a receiving device identification number (RDIN); receiving, by the RD, a registration message including a measuring device identification number (MDIN) from a measuring device (MD); registering, by the RD, the MD by means of the MDIN if the registration message from the MD includes the RDIN; receiving, by the RD, one or more data messages from the MD, each data message including the MDIN and a physiological parameter; and processing the physiological parameter in each data message, by the RD, if the MD has been registered by the RD. The range of the transmission of the request message between the RD and the MD is shorter than the range of the transmission of each data message between the MD and the RD, and/or the range of the transmission of the registration message between the MD and the RD is shorter than the range of the transmission of each data message between the MD and the RD. Embodiments also provide a corresponding monitoring system.12-13-2012
20120226444Ventilator-Initiated Prompt Regarding High Delivered Tidal Volume - This disclosure describes systems and methods for monitoring and evaluating ventilatory data to provide useful notifications and/or recommendations. Indeed, many clinicians may not easily identify or recognize data patterns and correlations indicative of certain patient conditions or the effectiveness of ventilatory treatment. Further, clinicians may not readily determine appropriate adjustments that may address certain patient conditions or the effectiveness of ventilatory treatment. Specifically, clinicians may not readily detect or recognize the occurrence of high-delivered V09-06-2012
20120259555Dynamic and Differential Analysis - The present invention provides methods to improve upon prostate cancer screening, thereby saving lives and reducing morbidities of unwarranted biopsies and over-treatment. The methods use a systematic analysis of the growth rate of PSA from cancer and PSA variation and the way in which they might be used to distinguish high-risk cancers from no cancer. Approaches include Dynamic-Differential Strategy, Dynamic-Differential Analysis, and Dynamic Analysis.10-11-2012
20120259554TONGUE TRACKING INTERFACE APPARATUS AND METHOD FOR CONTROLLING A COMPUTER PROGRAM - A tongue tracking interface apparatus for control of a computer program may include a mouthpiece configured to be worn over one or more teeth of a user of the computer program. The mouthpiece can include one or more sensors configured to determine one or more tongue orientation characteristics of the user. Other sensors such as microphones, pressure sensors, etc. located around the head, face, and neck, can also be used for determining tongue orientation characteristics.10-11-2012
20100023273Characterization of Phenotypes by Gene Expression Patterns and Classification of Samples Based Thereon - Generally, the present invention applies a transformation to convert a probability distribution of gene expression signals in control samples to a uniform distribution. The uniform distribution allows better comparisons between expression levels for genes. The transformation is derived from gene expression signals of control data, and is applied to gene expression signals of phenotype data. The phenotype data can be represented in a matrix format. A number of gene expression patterns may be determined (in the form of submatrices) that will characterize the phenotype. The uniform distribution helps in this regard, as it allows better comparisons of patterns. The gene expression patterns can then be used to classify samples as belonging to the phenotype set. Preferably, a discriminant function is used to compare a sample with the gene expression patterns that characterize the phenotype. The discriminant function can determine a score that can be used to determine whether the sample belongs to the phenotype.01-28-2010
20120191359ORGANISM OPTICAL MEASUREMENT DEVICE - An organism optical measurement device having a light transmitter/receiver control unit for obtaining measurement data concerning brain activities and a measurement data display control unit for displaying the measurement data. The organism optical measurement device is further provided with a head surface appearance image acquiring unit for acquiring a head surface appearance image of a subject, a head surface appearance image display control unit for displaying the head surface appearance image, and a measurement-related position calculating unit for calculating the measurement-related position in the head surface appearance image from which the measurement data is obtained when an input device specifies the positions in the head surface appearance image corresponding to the positions of a light transmitting probe and a light receiving probe disposed on the head surface of the subject. The measurement data display control unit displays the measurement data in the measurement-related position in the head surface appearance image.07-26-2012
20120191358RISK CALCULATION FOR EVALUATION OF FETAL ANEUPLOIDY - The present invention provides processes for determining accurate risk probabilities for fetal aneuploidies. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples.07-26-2012
20090018779Flexible glucose analysis using varying time report deltas and configurable glucose target ranges - A diabetes data management system selects variable threshold parameters to that are utilized in a report. A first low threshold glucose reading and a first high threshold glucose reading for a before meal event timeframe are selected. A second low threshold glucose reading and a second high threshold glucose reading are selected for an after meal event timeframe. The threshold readings are stored in a database. The diabetes data management system analyzes glucose behavior around meal events. The system receives a plurality of glucose readings for a time period, receives a first time range as a pre-meal analysis period for the first meal event and receives a second time range as a post-meal analysis period for the first meal event. The system creates a graph which highlights the pre-meal analysis period, the post-meal analysis period, and displays the plurality of glucose readings for the time period.01-15-2009
20090018776SYSTEM AND METHOD FOR NORMALIZING DATA IN NUCLEIC ACID AMPLIFICATION PROCEDURES - The present invention provides systems and methods for normalizing data in nucleic acid amplification procedures. In general, the methods include: obtaining input from a user regarding a number of normalizer measurements to use in calculations; obtaining raw fluorescence measurements of one or more probe(s) over multiple cycles of the procedure; obtaining normalizer measurement(s); and normalizing the probe data using the normalizer measurement(s) specified by the user. The present invention also discloses software and a computer readable medium for carrying method steps of the invention. Reduced cycle times, decreased variability, and/or lower Ct values are obtained as a result of the normalization.01-15-2009
20120265446BIOMARKERS BASED ON SETS OF MOLECULAR SIGNATURES10-18-2012
20100305869TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.12-02-2010
20100305868Method and system for determining whether a drug will be effective on a patient with a disease - A process of determining whether a patient with a disease or disorder will be responsive to a drug, used to treat the disease or disorder, including obtaining a test spectrum produced by a mass spectrometer from a serum produced from the patient. The test spectrum may be processed to determine a relation to a group of class labeled spectra produced from respective serum from other patients having the or similar clinical stage same disease or disorder and known to have responded or not responded to the drug. Based on the relation of the test spectrum to the group of class labeled spectra, a determination may be made as to whether the patient will be responsive to the drug.12-02-2010
20120232803CHARACTERIZATION OF BLOOD HEMOSTASIS AND OXYGEN TRANSPORT PARAMETERS - An integrated system for determining a hemostasis and oxygen transport parameter of a blood sample, such as blood, is disclosed. The system includes a measurement system, such as an ultrasonic sensor, configured to determine data characterizing the blood sample. For example, the data could be displacement of the blood sample in response to ultrasonic pulses. An integrated aspect of the system may be a common sensor, sample portion or data for fast and efficient determination of both parameters. The parameters can also be used to correct or improve measured parameters. For example, physiological adjustments may be applied to the hemostatic parameters using a HCT measurement. Also, physical adjustments may be applied, such as through calibration using a speed or attenuation of the sound pulse through or by the blood sample. These parameters may be displayed on a GUI to guide treatment.09-13-2012
20120232804SYSTEM AND METHOD FOR PARAMETER ESTIMATION IN BIOLOGICAL PROCESSES - A method of measuring a biological process, the method including the steps of: (a) determining a probability density function for a series of repeated measurements of the biological process; (b) approximating the probability density function utilising a parametric formula; (c) determining a maximum likelihood estimator for the parametric formulation of the probability density function; and (d) utilising the maximum likelihood estimator for subsequent measurements of the biological process.09-13-2012
20120232802DETERMINING A PLANE OF AN ANATOMICAL BODY PART - A data processing method for determining the position of a main plane of an anatomical body part, comprising the steps of: ·providing absolute auxiliary point data which describe the position of at least one actual auxiliary point of the body part relative to a marker device attached to the body part, the at least one actual auxiliary point being outside the main plane; ·providing relative point data which constrain the possible positions of the main plane relative to the at least one actual auxiliary point; ·providing absolute main point data which describe the position of one or two actual main points of the body part relative to the marker device attached to the body part, said one or two actual main points lying in the main plane and/or calculating the position of at least one virtual main point relative to the marker device, said at least one virtual main point being in the main plane and being calculated based on the absolute auxiliary point data and the relative point data; ·calculating a position of the main plane relative to the marker device, wherein the calculation uses the relative point data and auxiliary point data as well as the provided absolute main point data and/or the calculated position of the at least one virtual main point.09-13-2012
20120232801METHOD AND SYSTEM FOR EVALUATING FEEDING PERFORMANCE OF INDIVIDUAL NEONATES - A method and system for computing a relative score indicative of an individual infant's feeding performance based, at least in part, upon a comparison of one or more feeding factor measurements of the individual infant with a corresponding database metric that is derived from a population-based sample of infants, where the comparison optionally provides a statistical association between normative metric values and adverse outcomes recorded for the same population-based sample and, thereby, a means for assessing the tested infant's risk for said adverse outcomes.09-13-2012
20130173176BIOLOGICAL SAMPLE MEASUREMENT SYSTEM - The present invention comprises a biological sample data management device (07-04-2013
20080300797TWO BIOMARKERS FOR DIAGNOSIS AND MONITORING OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE - The present invention identifies two circulating proteins that have been newly identified as being differentially expressed in atherosclerosis. Circulating levels of these two proteins, particularly as a panel of proteins, can discriminate patients with acute myocardial infarction from those with stable exertional angina and from those with no history of atherosclerotic cardiovascular disease. Such levels can also predict cardiovascular events, determine the effectiveness of therapy, stage disease, and the like. For example, these markers are useful as surrogate biomarkers of clinical events needed for development of vascular specific pharmaceutical agents.12-04-2008
20080300799System And Method For Multiple-Factor Selection - The disclosed subject matter provides techniques for multiple-factor selection. The factors can be features or elements that are jointly associated with one or more outcomes by their joint presence or absence. There may be a non-causative correlation between the factors, features, or elements and the outcomes. In some embodiments, Entropy Minimization and Boolean Parsimony (EMBP) is used to identify modules of genes jointly associated with disease from gene expression data, and a logic function is provided to connect the combined expression levels in each gene module with the presence of disease. The smallest module of genes whose joint expression levels can predict the presence of disease can be identified.12-04-2008
20080300796BIOLOGICAL ANALYSIS METHODS, BIOLOGICAL ANALYSIS DEVICES, AND ARTICLES OF MANUFACTURE - Biological analysis methods, biological analysis devices, and articles of manufacture are described. Biological analysis methods access data regarding one or more images of a plurality of different combinations of biological receptors which individually have reacted with one or more biological indicators of a biological sample, analyze the data, and based on the analysis, create a profile comprising values representative of the biological indicators. Other biological analysis methods first access a plurality of first values individually corresponding to a plurality of biological indicators of a first subject, second access a plurality of second values individually corresponding to a plurality of biological indicators of a second subject, analyze the first and second values with respect to one another, and provide information regarding similarity of the first subject and the second subject using the analysis.12-04-2008
20080300794SYSTEM, METHOD, APPARATUS AND COMPUTER PROGRAM PRODUCT FOR CAPTURING HUMAN-READABLE TEXT DISPLAYED ON A UNIT DOSE PACKAGE - A system, method, apparatus and computer program product are provided for capturing human-readable text displayed on a unit dose package. In particular, identification information associated with a unit dose package may be used to determine a location and/or a format in which human-readable text, such as an expiration date or lot number associated with the corresponding unit dose medication, is displayed on the unit dose package. Once the location and/or format of the human-readable text has been determined, this information can be used in order to scan the unit dose medication and translate the human-readable text into machine-readable text using, for example, optical character recognition.12-04-2008
20080300798CARDIBIOINDEX/CARDIBIOSCORE AND UTILITY OF SALIVARY PROTEOME IN CARDIOVASCULAR DIAGNOSTICS - Embodiments of the invention include methods by which cardiac biomarkers are assigned an index (cardiovascular biomarker index-cardiobioindex, CBI) as a means to describe the utility of each biomarker, or combination of biomarkers for risk evaluation, diagnosis or prognosis of cardiovascular disease status.12-04-2008
20120239305HIGH-RESOLUTION MELTING ANALYSIS - The application relates to methods and systems for analysis of dissociation behavior of nucleic acids and identification of nucleic acids. In one aspect, methods and systems are disclosed for identifying a nucleic acid in a sample including an unknown nucleic acid and for detecting a single nucleotide polymorphism in a nucleic acid in a sample. Methods and systems are also disclosed for identification of a nucleic acid in a biological sample including at least one unknown nucleic acid by fitting denaturation data including measurements of a quantifiable physical change of the sample at a plurality of independent sample property points to a function to determine an intrinsic physical value and to obtain an estimated physical change function, and identifying the nucleic acid in the biological sample by comparing the intrinsic physical value for at least one unknown nucleic acid to an intrinsic physical value for a known nucleic acid.09-20-2012
20120239303System and Method for Health Monitoring Using Real-Time Location - In certain embodiments, a method includes storing location information associated with a dairy livestock. The stored location information includes a location of the dairy livestock within a free stall pen at each of a plurality of times during a time period. The method further includes determining, based on at least a portion of the stored location information, one or more movement parameters associated with the dairy livestock. The method further includes determining, based on the one or more movement parameters associated with the dairy livestock, whether the dairy livestock is likely unhealthy.09-20-2012
20110130969Resonant-Wavelength Measurement Method For Label-Independent Scanning Optical Reader - A method of measuring a resonant wavelength of a resonant waveguide (RWG) biosensor in an array of RWG biosensors supported by a microplate in a label-independent optical reader is disclosed. An exemplary method includes scanning a light spot over the RWG biosensor to obtain a plurality of spectra from both a central portion and at least one edge portion of the RWG biosensor. The method includes calculating a weighted-average spectrum for the biosensor by averaging the plurality of spectra while applying greater weight to the central portion than to the at least one edge portion. The method includes determining the resonant wavelength from the weighted-average spectrum. The resulting resonant wavelength measurement has substantially reduced noise and provides improved performance for label-independent scanning optical reader systems that use scanned optical beams.06-02-2011
20120265447 METHOD FOR COMBINING INDIVIDUAL RISK VARIABLES DERIVED FROM CARDIOPULMONARY EXERCISE TESTING INTO A SINGLE VARIABLE - A method of pattern recognition for classifying the functional status of patients with chronic disease comprising characterizing the functional status based on a multivariable index (MVI) scoring system wherein the MVI is computed by summing a plurality of individual variable values as individual variable indexes (IVI) and dividing the sum by the number of variables and wherein the plurality of IVI includes rest PetCO10-18-2012
20110010099Correlation Analysis of Biological Systems - The present teachings relate to gaining insight into biological states, e.g., disease states or drugged states, by gathering, integrating, and combining biomolecular data. More particularly, the present teachings relate to methods and systems for profiling a state of a biological system, finding accessible biomarkers representative of the state of a biological system, and deriving insights into the biochemistry of a biological system for therapeutic, diagnostic, prognostic and other purposes.01-13-2011
20110046887METHOD FOR ASSESSING PATHWAY PRODUCT LEVELS - This document relates to assessing homeostasis within mammals. For example, methods and materials for determining whether or not a biological system is functioning normally are provided.02-24-2011
20110224911METHODS AND MATERIALS FOR CANINE BREED IDENTIFICATION - In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations.09-15-2011
20090024331METHODS AND PROCESSES FOR CALLING BASES IN SEQUENCE BY INCORPORATION METHODS - Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.01-22-2009
20110046895Method and Device for Utilizing Analyte Levels to Assist in the Treatment of Diabetes - A health-monitoring device assesses the health of a user based on levels of two analytes in a biological fluid. A first analyte that is utilized to assess a user's health is a fat metabolism analyte, such as ketones, free fatty acids and glycerol, which is indicative of fat metabolism. A second analyte that is utilized is a glucose metabolism analyte, such as glucose. The levels of the two analytes may be used to assess insulin sensitivity, to detect both recent hypoglycemia and the cause of high glucose levels, and/or to guide therapeutic intervention. The dual analyte model may calculate a discrepancy between an actual insulin activity level and a theoretical insulin activity level. The dual analyte model of the present invention may be used to identify individuals at risk for metabolic syndrome, insulin resistance and non-insulin dependent diabetes, and allows monitoring of the progression of those disease states, as well as progress made by therapeutic interventions.02-24-2011
20110046893METHOD FOR NORMALIZING THE RESULTS OF AN IN-VITRO ANALYTICAL METHOD - A method is disclosed for normalizing the results of an in-vitro analytical method for one or more diagnostically and/or prognostically relevant substances in an organism (biomarker) or one or more substances supplied to an organism from the outside. In at least one embodiment of the method a) one or more concentration values of the substance(s) in an organism, said concentration value(s) being obtained in an in-vitro analytical method is (are) provided, b) data obtained from an imaging study of the same organism are provided, c) from the data according to b), one or more quantitative values are determined as imaging value(s), d) from the values according to a) and c), one or more diagnostic parameters are determined by relating the values according to a) and c) to one another, and also to the use of this method for the type-correct dosage finding of drugs and for the in-vitro diagnosis, prognosis and monitoring the course of a disease. In addition, at least one embodiment of the invention relates to a program for a data processing system which, when carried out in a suitable computer system, carries out the above method, and also to an electronically readable data carrier having electronically readable control information stored thereon, which control information is configured in such a manner that they carry out the above method when a suitable data carrier is used in a suitable computer system.02-24-2011
20110046890Method for accurately determining concentrations of diffusible materials - The invention provides an improved microdialysis method for determining the free concentration of an agent or drug (defined as the concentration of agent that is dissolved and free to diffuse, and not undissolved or precipitated, complexed, bound, included in micelles or microemulsions, etc.).02-24-2011
20110046889ENVIRONMENTAL MONITORING SYSTEM FOR CANINES, FELINES, OR OTHER ANIMALS - An apparatus for measuring, storing and communicating measurements of a dog, cat, other animal or inanimate object's environment. The apparatus may take the form of a collar, bridle, tag, harness or other mechanism worn by the animal or a device to be shipped with the animal or inanimate object. The apparatus may include mechanisms to initiate and terminate measurement and may include the ability to detect and report values exceeding specified limits.02-24-2011
20120330565SYSTEM AND METHOD FOR EVALUATING PHYSIOLOGICAL PARAMETER DATA - Embodiments disclosed herein may include systems and methods for evaluating physiological parameter data. Embodiments of methods may include monitoring a patient to produce a signal comprising a sequence of numerical values for a physiological parameter over a time period, calculating an index from the signal, comparing the index to a reported index, and if the index is greater than the reported index, setting the reported index to the value of the index. Embodiments of methods may include calculating a modulation of the signal, comparing the modulation to a previous valise of the modulation to identity a trend in the modulation and if the trend corresponds to an undesirable condition, using a first function, to increase the reported index. Embodiments of methods may include providing an indication of a physiological status based on the reported index.12-27-2012
20120330563Assembly Error Detection - A method for detecting errors in genetic sequence assemblies including defining an assembly (A) of a sequence of genetic data, collecting read data into a library of reads (L), plotting histograms of sizes or reads versus a number of reads per size, normalizing a distribution (D) with a coverage C to obtain D′ that has a mean (μ) and standard deviation (σ) and reserve positions (i) not used to obtain D′, collecting subset of reads (S12-27-2012
20120330562VARIABLE INDICATION ESTIMATOR - A variable indication estimator which determines an output value representative of a set of input data. For example, the estimator can reduce input data to estimates of a desired signal, select a time, and determine an output value from the estimates and the time. In one embodiment, the time is selected using one or more adjustable signal confidence parameters determine where along the estimates the output value will be computed. By varying the parameters, the characteristics of the output value are variable. For example, when input signal confidence is low, the parameters are adjusted so that the output value is a smoothed representation of the input signal. When input signal confidence is high, the parameters are adjusted so that the output value has a faster and more accurate response to the input signal.12-27-2012
20120330560METHOD AND SYSTEM FOR PREDICTING PERTUBATIONS ALTERING METABOLIC STATES - A computer implemented method for identifying genetic or environmental perturbations that induce a transformation from a source state of an individual to a target state. A flux description of reactions is calculated in the source state and a statistical test is performed on the gene expression levels of the source state versus the target state, to generate a P-value for each on the plurality of genes. Then, for each reaction the flux of the reaction in the source state is fixed and a solution for all of the fluxes that minimize an objective function is found. These perturbations are ranked by the extent by which the perturbation caused a transformation of the source state towards the target state.12-27-2012
20120330561METHOD AND APPARATUS FOR PROVIDING DATA PROCESSING AND CONTROL IN A MEDICAL COMMUNICATION SYSTEM - Methods and apparatus for providing data processing and control for use in a medical communication system are provided.12-27-2012
20120330559SYSTEMS AND METHODS FOR HYBRID ASSEMBLY OF NUCLEIC ACID SEQUENCES - Systems and methods for assembling a nucleic acid sequence are disclosed. A plurality of single fragment sequence reads and a plurality of paired fragment sequence reads are received. Each paired fragment sequence read comprises at least two sequence reads separated by an insert. Single fragment sequence reads are assembled into a plurality of contigs, and the paired fragment sequence reads are mapped to the contigs. Further, gap regions comprising a portion of the partially assembled nucleic acid sequence for which the single fragment sequence reads do not map are identified, and hanging pairwise sequence reads of the mapped paired fragment sequence reads are used to fill in the gap region.12-27-2012
20120330556Analyte Testing System with Docking Station for Data Management - An analyte testing system having an analyte testing device and a docking station is described. The analyte testing device includes a plurality of lancets, a plurality of analyte sensors, electronics for deriving test data from the analyte sensors, a visual display that displays test data, and a data recording facility that records non-test data. Examples of non-test data include text diary information, audio diary information, food eaten, minutes exercised, medication taken, and estimated calories burned. The docking station has a power interface and data interface that provide power and data connectivity to the testing device. The docking station also has a storage facility configured to automatically store the test data and non-test data.12-27-2012
20120330558IDENTIFICATION OF BIOMARKERS - The present invention relates to a method comprising the steps of obtaining a sample from the subject, measuring a plurality of biomolecules in the sample, identifying the measured biomolecules in the sample, characterized in that the method further comprises the steps of estimating a discriminatory ability of each measured biomolecule by using a paired test hypothesis, and integrating the estimated discriminatory abilities of the biomolecules into a kinetic analysis. More particularly, the present invention enables the use of such a method and a method for monitoring progress or treatment of a disease such as cardiovascular diseases. Such identification methods comprising the steps of obtaining a sample from the subject, measuring a plurality of biomolecules in the sample and identifying the measured biomolecules can particularly be used for monitoring progress or treatment of a disease.12-27-2012
20120330557System for Cardiac Condition Analysis Based on Cardiac Operation Patterns - A system for heart performance monitoring stores image data representing a sequence of medical images of a surface of a patient heart acquired over multiple contraction and reperfusion cycles. An image data processor automatically processes the image data to determine, change in displacement of selected points of a region of interest of the heart surface over individual cycles of the multiple contraction and reperfusion cycles, maximum and minimum peak displacement points and associated relative times of occurrence of the maximum and minimum peak displacement points and individual parameters related to change in displacement of corresponding individual points of the selected points. A display image shows a grid of individual parameters and an individual grid cell employs a visual attribute to visually indicate degree of change in an associated individual parameter occurring over the multiple contraction and reperfusion cycles.12-27-2012
20120330555Analyte Testing System with Docking Station for Data Management - An analyte testing system having an analyte testing device and a docking station is described. The analyte testing device includes a plurality of lancets, a plurality of analyte sensors, electronics for deriving test data from the analyte sensors, a visual display that displays test data, and a data recording facility that records non-test data. Examples of non-test data include text diary information, audio diary information, food eaten, minutes exercised, medication taken, and estimated calories burned. The docking station has a power interface and data interface that provide power and data connectivity to the testing device. The docking station also has a storage facility configured to automatically store the test data and non-test data.12-27-2012
20120323497Non-Hypergeometric Overlap Probability - Methods, software, and systems are provided for determining the probability of an overlap set of entities having an overlap size, where the overlap set is independently selected from two sets of non-identical entities. Applications of the invention to microarrays are provided. Probability distributions are provided for determining the probability that the size of an overlap gene set from two different microarrays occurs by chance. Microarray analysis for determining the size of a statistically significant overlap gene set given two different microarrays is described. Overlap set size probability determinations that account for the total number of genes in two different microarrays and not just the common genes are described.12-20-2012
20120323496Tracking of User Performance Metrics During a Workout Session - Example embodiments may relate systems, methods, apparatuses, and computer readable media configured to process input specifying a user attribute, adjust a performance zone based on the user attribute, receive data generated by at least one of an accelerometer and a force sensor, determine whether the data is within the performance zone, and output the determination.12-20-2012
20120271557Information Processing Apparatus and User Terminal - Disclosed is an information processing apparatus capable of communicating with a user terminal which acquires a first index value for reflecting a state of a first biological component of a user and evaluating a metabolic result of the first biological component in a certain period of time on the basis of the first biological component and which provides the acquired first index value to the user, wherein calibration curve data is delivered to the user terminal in order to use the calibration curve data for acquiring the first index value.10-25-2012
20120271559Determining Analyte Concentrations in Biological Fluids with Abnormal Output Detection - A biosensor has an abnormal output detection system that determines whether an output signal from the redox reaction of an analyte has a normal or abnormal shape or configuration. The abnormal output detection system improves the accuracy and precision of the biosensor in determining whether an output signal has a shape or configuration that may not provide an accurate and/or precise analysis of a biological fluid. The biosensor generates an output signal in response to the redox reaction of the analyte. The biosensor normalizes the output signal and compares the normalized output signal with one or more control limits. The biosensor may generate an error signal when the normalized output signal is not within the control limits.10-25-2012
20120271560Asthma Status Scoring Method and System With Confidence Ratings - A method and system for assessing the health status of a patient, such as the asthma status of a patient, provides an asthma status score and a confidence rating indicative of the score's reliability using continuous real-time data. In some embodiments, the assessment comprises a multidimensional analysis in which asthma status scores and respective confidence ratings are generated for multiple individual asthma health dimensions as well as a summary asthma health dimension indicative of overall asthma health. In some embodiments, the individual dimensions include an environmental trigger dimension based on sensor-based environmental data, a physiological burden dimension based on sensor-based physiological data, a medication adherence dimension based on patient diary data and a perceived symptom dimension based on patient diary data.10-25-2012
20120271558SYSTEM AND METHOD FOR IDENTIFYING AND CLASSIFYING RESISTANCE GENES OF PLANT USING HIDDEN MARCOV MODEL - The present invention relates to a system and a method for quickly and accurately identifying and classifying resistance genes of a plant from a protein or DNA sequence. In order to identify and classify resistance genes of a plant using a hidden marcov model, conceived is a profile matrix made using a protein sequence of a domain which is encoded by the resistance genes, and a system for identifying the domain of the resistance genes using the profile matrix and classifying the resistance genes by domain combination. The present invention enables effective identification and classification of the resistance genes of a plant using the profile matrix and program, of which the nucleotide base sequence or protein sequence is detected.10-25-2012
20120271554Systems and Methods Utilizing Plethysmographic Data - Disclosed are apparatus, systems and methods utilizing attributes of the cardiac signal to calibrate/normalize components of the plethysmographic (PG) waveform indicating changes in venous and arterial blood volume. In the time-domain, amplitudes of respiratory-induced variations of the DC and AC components of the PG waveform may be calibrated/normalized based on an average amplitude of the PG waveform, e.g., over a respiratory cycle. Similarly, in the frequency domain, respiratory signal strength and side-band signal strength may be advantageously calibrated/normalized based on the strength of the cardiac signal or a harmonic thereof.10-25-2012
20120271556METHOD AND DEVICE FOR ESTIMATING BIOLOGICAL OR CHEMICAL PARAMETERS IN A SAMPLE, CORRESPONDING METHOD FOR AIDING DIAGNOSIS - This method for estimating biological or chemical parameters in a sample (E) comprises steps consisting of putting (10-25-2012
20110213562FLUORESCENT AGENT CONCENTRATION MEASURING APPARATUS, DOSE CONTROL APPARATUS, ADMINISTRATION SYSTEM, FLUORESCENT AGENT CONCENTRATION MEASURING METHOD, AND DOSE CONTROL METHOD - A fluorescent agent accumulation concentration measuring apparatus is configured to include a single-wavelength LED to radiate excitation light to a test bottle loaded in the inside, a barrier filter to transmit only fluorescence from the test bottle, a photoreceptor to receive the fluorescence through the barrier filter and output an electric signal, a detection processing circuit to conduct signal processing of the electric signal from the photoreceptor and detect the fluorescence intensity, and an operation circuit 09-01-2011
20110213559MULTI-SENSOR PATCH AND SYSTEM - Embodiments of the invention provide systems and methods for remote sensing and/or monitoring utilizing a sensing device, such as may be implemented in a patch that can be placed on or affixed to a subject, where the sensing device includes multiple sensors. For example, one embodiment of the present invention includes a wireless human temperature skin patch providing accurate measurement of human temperature from a sensing device applied to the skin and even in the presence of differing ambient temperature. In such an embodiment, the patch can include, for example, a flexible, breathable bandage or adhesive strip or pad to affix the sensing device to a patient. The sensing device can include multiple sensors such as two or more temperature sensors that can be used to accurately determine the patient's core body temperature from the measured temperature at the skin.09-01-2011
20110224915METHOD AND APPARATUS FOR A SELF-POWERED RFID-READABLE PEDOMETER - A device, system and method for analyzing a user's motion using a piezoelectric film to generate a plurality of deformation signals based upon an associated plurality of deformations, an EEPROM to record data associated with the plurality of deformation signals, and a transceiver to receive at least a portion of the recorded data from the EEPROM and to transmit data, wherein the analysis may determine an abnormality in the user's gait.09-15-2011
20110238326BIOLOGICAL INFORMATION ACQUIRING SYSTEM AND BIOLOGICAL INFORMATION ACQUIRING METHOD - It is an object of the present invention to provide a biological information acquiring system and a biological information acquiring method capable of enhancing the calculation accuracy to more accurately calculate the exercise effect information, and capable of enhancing the satisfaction level of the user.09-29-2011
20110238325Quantitative, multispectral image analysis of tissue specimens stained with quantum dots - A biological sample such as a tissue section is stained with one or more quantum dots and possibly other fluorophores (total number of fluorophores N). A camera coupled to a microscope generates an image of the specimen at a plurality of different wavelengths within the emission spectral band of the N fluorophores. An analysis module calculates coefficients C09-29-2011
20110238324BIOLOGICAL INFORMATION MEASURING DEVICE AND CONTROL METHOD THEREOF - A biological information measuring device including: a finger insertion part (09-29-2011
20110238323SYSTEMS AND METHODS FOR AUTOMATED MELTING CURVE ANALYSIS - An experimental melting curve is modeled as a sum of a true melting curve and background fluorescence. A deviation function may be generated based upon the experimental melting curve data and a model of a background signal. The deviation function may be generated by segmenting a range of the experimental curve into a plurality of windows. Within each window, a fit between the model of the background signal and the experimental melting curve data may be calculated. The deviation function may be formed from the resulting fit parameters. The deviation function may include background signal compensation and, as such, may be used in various melting curve analysis operations, such as data visualization, clustering, genotyping, scanning, negative sample removal, and the like. The deviation function may be used to seed an automated background correction process. A background-corrected melting curve may be further processed to remove an aggregation signal.09-29-2011
20110238322METHODS OF SIMULATING CHEMOTHERAPY FOR A PATIENT - The present invention provides methods for predicting or modeling a chemotherapy outcome for a given patient The method produces chemoresponse data, and presents the chemoresponse data in a clinically meaningful context such that the data can be meaningfully interpreted and evaluated in a clinical context The method of the invention involves correlating in vitro chemoresponse results for a particular patient with historical treatment outcomes Where a population of historical outcomes are matched to the patient by one or more clinical variables and such outcomes are matched to a potential treatment by the in vitro efficacy of the agent received, a meaningful simulation of the potential treatment for the patient can be constructed Simulations, such as survival curves, for a plurality of potential treatments may be generated and compared to contrast the estimated outcomes for several potential treatments, thereby providing the information desirable to design an individualized treatment regimen.09-29-2011
20110238321Methods for Assessing Drug Efficacy and Response of Patient to Therapy - Methods of identifying, monitoring and matching patients with appropriate treatments who are at risk for developing a systemic inflammatory condition using a systemic mediator-associated physiologic test profile are provided. The methods of the present invention increase the likelihood of demonstrating clinical efficacy in clinical trial datasets.09-29-2011
20110238319 METHOD OF DIAGNOSING A RESPIRATORY DISEASE - There is provided, a method of diagnosing a disease state in a subject comprising: (a) obtaining nuclear magnetic resonance data on an obtained biological sample from the subject; (b) performing a statistical analysis on the nuclear magnetic resonance data; (c) determining a subject profile for the biological sample based on the statistical analysis; (d) comparing the subject profile to a predetermined profile for differentiating between: (i) the disease state and a non-diseased state; (ii) a first disease state and a second disease state, or (iii) the first disease state, the second disease state, and the non-diseased state, to provide a diagnosis of the disease state, wherein the comparing does not comprise identification of components of the biological sample.09-29-2011
20110238318Simple algorithm for quantifying polymorphisms in electropherograms - A method for quantifying cytosine methylation at a particular target CpG site in DNA of a cell or organism, by performing bisulfite genomic sequencing, wherein a DNA sample extracted from a cell or organism is treated with sodium bisulfite to convert cytosine to uracil and a selected fragment of this treated DNA is amplified, performing a sequence analysis of the amplificate from an electropherogram wherein the area under a peak is measured in a plurality of peaks at either side of the target CpG site to determine the mean T area (T bar) surrounding the site, subtracting the area of the T at the target CpG site from the mean T area wherein the difference is termed delta T, and calculating the proportional level of methylation as a quotient of delta T/T bar, or as a percent value, is presented.09-29-2011
20110238317System for forecasting outcomes of clinical trials - A system for forecasting outcomes of clinical trials including a digital computer having a central processor, a programmable graphical or programmable analog coprocessor in communication with the central processor, interface software in communication with the central processor and coprocessor, modeling software having simulation capability substantially executed by the central processor and in communication with the interface software, integration software substantially executed by the central processor in communication with the modeling software, partial derivative software substantially executed by the coprocessor and in communication with the interface software, a historical clinical trial data component, a model data component specifying the time course of a clinical observation by a differential equation, and a protocol data component specifying the characteristics of a population intended to undergo a future clinical trial, all the said data components in communication with the modeling software.09-29-2011
20110238316SECONDARY STRUCTURE DEFINING DATABASE AND METHODS FOR DETERMINING IDENTITY AND GEOGRAPHIC ORIGIN OF AN UNKNOWN BIOAGENT THEREBY - The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.09-29-2011
20100235105METHOD FOR ANALYZING DYNAMIC DETECTABLE EVENTS AT THE SINGLE MOLECULE LEVEL - A method to be implemented on or in a computer is disclosed, where the method includes data collection, calibration, candidate selection, and analysis of data streams associated with each candidate to classify single molecule fluorescence resonance energy transfer events. Once classified, the classification can be related to the nature of the events, such as the identification of dNTP incorporation during primer extension to obtain a base read out of an unknown template.09-16-2010
20120277998System And Methods For Characterizing A Biological Condition Or Agent Using Selected Gene Expression Profiles - Methods are provided for evaluating a biological condition of a subject using a calibrated profile data set derived from a data set having a plurality of members, each member being a quantitative measure of the amount of a subject's RNA or protein as distinct constituents in a panel of constituents. The biological condition may be a naturally occurring physiological state or may be responsive to treatment of the subject with one or more agents. Calibrated profile data sets may be used as a descriptive record for an agent.11-01-2012
20120278001Signal Procesing Systems and Methods Using Basis Functions and Wavelet Transforms - According to embodiments, systems and methods are provided that use continuous wavelet transforms and basis functions to provide an optimized system for the determination of physiological information. In an embodiment, the basis functions may be used to refine an area of interest in the signal in frequency or in time, and the continuous wavelet transform may be used to identify a maxima ridge in the scalogram at scales with characteristic frequencies proximal to the frequency or frequencies of interest. In another embodiment, a wavelet transform may be used to identify regions of a signal with the morphology of interest while basis functions may be used to focus on these regions to determine or filter information of interest. In yet another embodiment, basis functions and continuous wavelet transforms may be used concurrently and their results combined to form optimized information or a confidence metric for determined physiological information.11-01-2012
20120277999METHODS, KITS AND ARRAYS FOR SCREENING FOR, PREDICTING AND IDENTIFYING DONORS FOR HEMATOPOIETIC CELL TRANSPLANTATION, AND PREDICTING RISK OF HEMATOPOIETIC CELL TRANSPLANT (HCT) TO INDUCE GRAFT VS. HOST DISEASE (GVHD) - The invention relates to predicting or determining risk of a hematopoietic cell transplant (HCT) from a donor to induce Graft vs. Host Disease (GVHD) in a HCT recipient; to classifying HCT from a candidate donor according to the risk of inducing GVHD in a HCT recipient; and to organizational constructs (e.g., databases) and methods of producing organizational constructs (e.g., databases) in which HCT of one or more candidate donors is classified or scored according to risk of inducing GVHD in a HCT recipient. The invention also relates to kits and arrays useful for predicting or determining risk of HCT from a candidate donor to induce GVHD in a HCT recipient, and for classifying or scoring such donors according to risk of inducing GVHD in a HCT recipient.11-01-2012
20120089340ANIMAL IDENTIFICATION, MEASUREMENT, MONITORING AND MANAGEMENT SYSTEM - A highly automated system and method for acquiring animal consumption and behavior data comprising stations where consumables are fed to animals. The stations being equipped with RFID equipment for reading RFID tags in close proximity to the station, and weighing devices for measuring the weight of the consumables. The RFID equipment and the weighing device are connected to a computer which calculates the weight of the trough at specific times by using weight data collected before and after the specified time to enhance the accuracy of the weight measurement. The computer uses a “mathematical weighted filter technique” to estimate the weight of the trough before and after a consumption event. The computer uses a method to divide the reduction/increase in weighed matter between the RFID tag last seen and the next RFID tag appearing, providing the reduction/increase in matter is less than a specified amount.04-12-2012
20120089339METHOD AND SYSTEMS FOR PROCESSING POLYMERIC SEQUENCE DATA AND RELATED INFORMATION - Methods and systems for organizing, representing and processing polymeric sequence information, including biopolymeric sequence information such as DNA sequence information and related information are disclosed herein. Polymeric sequence and associated information may be represented using a plurality of data units, each of which includes one or more headers and a payload containing a representation of a segment of the polymeric sequence. Each header may include or be linked to a portion of the associated information.04-12-2012
20120089338COMPUTER IMPLEMENTED METHOD FOR INDEXING REFERENCE GENOME - A method for indexing a reference genome is provided. The method includes selecting a reference genome to index, calculating a first minimum index region size, assigning a first position number to a first index region of the reference genome, assigning a second position number to a second index region of the reference genome, and storing the association of the first and second position numbers to index regions in a hash table. The size of the first index region can be greater than or equal to the first minimum index region size. The second index region can overlap with at least one base included in the first index region. The first minimum index region size can be calculated based on the reference genome size. In yet other embodiments of the present teachings, a method for mapping a sequence read to a reference genome is provided wherein a sequence read is compared to the index regions stored in the indexing hash table, and the sequence read is mapped to and aligned against a location on the reference genome. Systems configured to carry out the methods are also provided.04-12-2012
20110276276APPARATUS AND METHOD FOR DETERMINING ANALYTE CONCENTRATIONS - An apparatus and method for determining an analyte concentration of a sample, such as a tissue sample. The apparatus may comprise an emitter, close proximity detectors laterally located less than about 2 mm away from the emitter, and far away detectors laterally located greater than about 0.5 cm away from the emitter. A plurality of wavelengths may be sent from the emitter to the sample, reflected off of the sample, and received by the detectors. The reflectance value measured by the close proximity detectors may be used to calculate one or more scattering coefficients. The reflectance value measured by the far away detectors may be compared with a reflectance value calculated using the scattering coefficients in a numerical inversion of a diffusion model to determine the analyte concentration of the sample.11-10-2011
20110276275Systems And Methods For Wavelet Transform Scale-Dependent Multiple-Archetyping - Methods and systems are disclosed for producing a plurality of archetype signals in wavelet space at a plurality of wavelet scales. A signal is transformed using a continuous wavelet transform based at least in part on a wavelet function. A scale dependent archetype transformed signal is computed based at least in part on the transformed signal and based at least in part on a natural periodicity of the wavelet function used to transform the signal. Information may be derived about the signal from the archetype transform signal, and stored in memory.11-10-2011
20120330564Method of Pre-Treatment and Staining of a Biological Sample and Device for Support of a Biological Sample and Methods of Using Such Device - There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.12-27-2012
20110282586SYSTEMS AND METHODS TO DETERMINE OPTIMAL DIAMETERS OF VESSEL SEGMENTS IN BIFURCATION - Systems and methods to determine optimal diameters of vessel segments in bifurcation. In at least one embodiment of a method for determining a diameter of a segment of a bifurcated vessel of the present disclosure, the method comprises the steps of identifying a diameter of a first segment of a bifurcated vessel, identifying a diameter of a second segment of the bifurcated vessel, and determining a diameter of a third segment of the bifurcated vessel based upon the diameter of the first segment and the diameter of the second segment, wherein the determination is further based upon an exponential relationship of or about 7/3 for each diameter.11-17-2011
20110295517NMR ANALYZERS FOR CLINICAL EVALUATION OF BIOSAMPLES - The clinical analyzers automatically electronically monitor selected parameters and automatically electronically adjust parameters to maintain the analyzer within desired operational ranges. The clinical NMR analyzers can be configured as a networked system with a plurality of clinical NMR analyzers located at different use sites.12-01-2011
20110295516BIOINFORMATIC APPROACH TO DISEASE DIAGNOSIS - A kit and test panel utilizing a multivariate diagnostic method based on optimizing diagnostic likelihood ratios through the effective use of multiple diagnostic tests is disclosed. The Neyman-Pearson Lemma provides a mathematical basis to produce optimal diagnostic results. The method can comprise identifying those tests optimal for inclusion in a diagnostic panel, weighting the result of each component test based on a multivariate algorithm described below, adjusting the algorithm's performance to satisfy predetermined specificity criteria, generating a likelihood ratio for a given patient's test results through said algorithm, providing a clinical algorithm that estimates the pretest probability of disease based on individual clinical signs and symptoms, combining the likelihood ratio and pretest probability of disease through Bayes' Theorem to generate a posttest probability of disease, interpreting that result as either positive or negative for disease based on a cutoff value, and treating a patient for disease if the posttest probability exceeds the cutoff value.12-01-2011
20110320130SYSTEMS AND METHODS FOR COMMUNICATING SENSOR DATA BETWEEN COMMUNICATION DEVICES - System and method for communicating glucose concentration information between devices of a continuous glucose monitoring system is provided. The continuous glucose monitoring system can include a sensor module generates a glucose concentration measurement data and transmits the data to one or more further devices of the continuous glucose monitoring system. The further devices can include a receiver unit and one or more secondary display devices. The receiver unit can be configured to be a stand-alone device of or physically connect to a secondary display device. A user interface can also be provided that provides enhanced functionality for using the continuous glucose monitoring system.12-29-2011
20120101733METHOD AND APPARATUS FOR PROCESSING IMAGE AND MEDICAL IMAGE SYSTEM PERFORMING THE METHOD - An image processing apparatus is provided. The image processing apparatus includes an image mapping unit for generating a mapping image in which first radiation images of multi-energy bands with respect to a local region of a body are mapped to a second radiation image with respect to a thickness variable phantom, an image analyzing unit for analyzing a reference region corresponding to normal tissue in the local region and a peculiar region corresponding to abnormal tissue in the local region based on the mapping image, and an enhancement image generating unit for generating a tissue enhancement image that has a shape of the local region in the first radiation images and enhances regions of pixel positions, that are mapped to the peculiar region, of the first radiation images.04-26-2012
20120101737BIOSENSING DEVICE - The present invention provides a biosensing device, comprising an input unit, an analysis unit, a process unit, and a set unit for storing resulting data values as the basis for calibrating the biosensing device, to set up the calibration parameters of a strip of the biosensing device.04-26-2012
20120101736Method and System for Computing and Integrating Genetic and Environmental Health Risks for a Personal Genome - Methods and systems are provided for the computation and display of an individual's personalized health risk based on the genome sequence of the individual, known etiological interactions between diseases for which the individual is determined to have genetic risk factors, and environmental etiological factors associated with the same diseases that represent potentially modifiable disease risk modifiers.04-26-2012
20120101735METHOD AND APPARATUS FOR RECOGNIZING AN EMOTION OF AN INDIVIDUAL BASED ON FACIAL ACTION UNITS - An apparatus and method are provided for recognizing an emotion of an individual based on Action Units. The method includes receiving an input AU string including one or more AUs that represents a facial expression of an individual from an AU detector; matching the input AU string with each of a plurality of AU strings, wherein each of the plurality of AU strings includes a set of highly discriminative AUs, each representing an emotion; identifying an AU string from the plurality of AU strings that best matches the input AU string; and outputting an emotion label corresponding to the best matching AU string that indicates the emotion of the individual.04-26-2012
20120101734Method of Predicting Placebo Non-Response - The present invention provides a method of reliably predicting the likelihood of a response to placebo among subjects in, or potentially enrolling in, clinical trials.04-26-2012
20120290217SYSTEM AND METHOD FOR TRACKING RECORDING AND ANALYZING SPATIAL ACTIVITY OF A SUBJECT FOR MEDICAL AND OTHER APPLICATIONS - The present invention is a method, circuit and system for characterizing one or more aspects of a subject's physical condition based on data generated by a localization device, such as an accelerometer, an inertial navigation system (INS), a global positioning system (GPS) unit or any combination thereof, carried by or affixed to the subject.11-15-2012
20120290215Calculating and Monitoring a Composite Stress Index - In particular embodiments, a method includes accessing data streams from a first group of physiological sensors monitoring a person, a second group of deconfounding sensors monitoring the person, and a third group of sensors monitoring a stressor, analyzing data sets collected from the person when the person is exposed and not exposed to the stressor, and determining a current stress factor for the stressor with respect to the person based on the analysis.11-15-2012
20120290216Method and System for Distinguishing Nociceptive Pain from Neuropathic Pain - A method of distinguishing nociceptive pain from neuropathic pain includes providing a series of questions for answering by the patient. Each of the answers by the patient are given a numerical value within a nociceptive pain category and a neuropathic pain category. The values within the two categories are then summed, with the resultants potentially modified using a series of one or more equations. The ratio of the neuropathic pain to the nociceptive pain is then calculated. The ratio provides a value for the physician to diagnose the patient as suffering from nociceptive pain, neuropathic pain, or both nociceptive pain and neuropathic pain. Embodiments of the present invention include a system for assisting a physician to identify whether a patient's pain is nociceptive pain or neuropathic pain.11-15-2012
20120290218Computational Analysis of the Synergy Among Multiple Interacting Factors - A method is provided for selecting two or more genes from gene expression data. In the method, gene expression data for a plurality of genes is provided, where the gene expression data include expression levels for each of the plurality of genes. The gene expression data is discretized. Based on the discretized gene expression data, the synergy among the plurality of genes with respect to a phenotype, for example, presence or absence of a disease in a tissue, is evaluated. Two or more genes whose synergy exceeds a predetermined threshold are selected. A system implementing the method is also provided.11-15-2012
20120136581Method of Diagnosing Asphyxia - A method for in vitro diagnosing asphyxia and disorders related thereto, a method of in vitro estimating duration of hypoxia in a patient subjected to asphyxia, and a method for in vitro monitoring of normoxic, hypoxic and hyperoxic conditions and/or normobaric and hyperbaric oxygen therapy, includes quantitatively detecting in a biological sample of a patient a plurality of asphyxia specific endogenous compounds which are selected from the group consisting of biogenic amines; carnitine-derived compounds; amino acids; bile acids; carboxylic acids; eicosanoids; lipids; precursors of cholesterol, cholesterol metabolites; prostanoids; and sugars.05-31-2012
20100198522Computer-Assisted Method of Analyzing a DNA Mixture - The present invention relates to a computer-assisted method of analyzing a DNA mixture having two or more individual contributors by use of STR technology. The method comprises the steps of obtaining, for a number of STR loci, observed peak area data vector and observed peak height data vector for each peak within a locus, and observed allele data informing which alleles are observed for each loci; and obtaining peak area model data for peak areas by use of a statistical model assuming a normal distribution for the peak areas and assuming conditional independence of the peak area vectors given the sums of the peak areas within each locus. A conditional mean vector and a conditional covariance matrix is proposed and used for the statistical model. The invention also proposes a method for determining, for each locus of the STR loci and by use of the proposed statistical model, a best matching combination of variables indicating the number of allele copies from each individual contributor to the mixture and thereby specifying the DNA mixture.08-05-2010
20100198521CHEMICALLY SENSITIVE FIELD EFFECT TRANSISTORS AND USES THEREOF IN ELECTRONIC NOSE DEVICES - The present invention provides an electronic nose device based on chemically sensitive field effect transistors. In particular, the sensors of the electronic nose device are composed of non-oxidized, functionalized silicon nanowires which can detect volatile organic compounds with very high sensitivity. Methods of use in diagnosing diseases including various types of cancer are disclosed.08-05-2010
20090216460METHOD TO DETERMINE THE DEGREE AND STABILITY OF BLOOD GLUCOSE CONTROL IN PATIENTS WITH DIABETES MELLITUS VIA CREATION AND CONTINUOUS UPDATING OF NEW STATISTICAL INDICATORS - Systems and methods for determining a stability of a blood glucose concentration of a patient are provided. The system comprises a processor that may be programmed to receive blood glucose concentration test results each taken from the patient at a different time over a time period and to compute a time-averaged glucose parameter indicative of blood glucose concentration control over the time period. In addition, the processor may be programmed to compute a virtual blood hemoglobin parameter through a simulated measurement of a blood hemoglobin, the virtual blood hemoglobin parameter being indicative of blood glucose concentration control over an extended time period encompassing the time period. Further, the processor may be programmed to compute a lability factor parameter indicative of a variability in blood glucose concentration over the time period.08-27-2009
20090281733METHOD FOR EVALUATING TREE PRODUCTION CAPACITY, IMAGE CAPTURE DEVICE FOR EVALUATING TREE PRODUCTION CAPACITY, AND PROGRAM FOR EVALUATING TREE PRODUCTION CAPACITY - Evaluation of tree production capacity by a non-destructive method using a tree crown structure measurement device or using an image capture device with a fisheye lens mounted, for isolated trees or for trees existing at intervals, is enabled without requiring a large amount of time.11-12-2009
20100169023Computational methods and systems for suggesting modulators of CYP450 as treatment options - Computational methods and systems are described which accept input, identify one or more CYP450-family enzymes, identify one or more modulators of the CYP450-family enzymes, and communicate treatments to at least one system user, wherein the treatments include one or more of the identified at least one modulator.07-01-2010
20100169024DEFINING QUANTITATIVE SIGNATURES FOR DIFFERENT GLEASON GRADES OF PROSTATE CANCER USING MAGNETIC RESONANCE SPECTROSCOPY - A method for classifying a possible cancer from a magnetic resonance spectrographic (MRS) dataset includes extracting at least one feature from the MRS dataset as being identified with the possible cancer and embedding the extracted feature into a low dimensional space to form an embedded space. The method then clusters the embedded space into clusters representing a plurality of predetermined classes and spectrally decomposing the clusters to identify substantially significant independent metabolic signatures. The method then classifies the possible cancer as belong to one of at least two cancer classes based on the identified independent metabolic signatures.07-01-2010
20100169022Computational methods and systems for treatment in relation to modulation of CYP450 enzyme activity - Methods and systems such as those described herein include accepting input, identifying CYP450-family enzymes, identifying at least one modulator of an enzyme, and communicating one or more treatments to a system user.07-01-2010
20130013218SYSTEMS AND METHODS FOR EVALUATING ENVIRONMENTAL ASPECTS OF SHIPPING SYSTEMS - According to various embodiments, package evaluation systems and methods are provided for evaluating the sustainability of packaging used in the shipment of goods. In particular, the package evaluation systems and methods are configured for performing package evaluations and managing and providing access to data resulting from package evaluations. The package evaluations are designed to assess, among other things, the ability of sample packages to prevent damage to their contents, the volumetric efficiency of sample packages, and the sustainability of the materials used to construct sample packages. In addition, the systems and methods are further configured for assigning a certification to an entity associated with the evaluated packages based on the results of the evaluation.01-10-2013
20130013217METHODS AND SYSTEMS FOR GENOMIC ANALYSIS USING ANCESTRAL DATA - The present disclosure provides methods and systems for assessing an individual's genotype correlations to a phenotype by analyzing the individual's genomic profile and using ancestral data to determine the correlations between genotypes and phenotypes.01-10-2013
20130013215COMPUTATIONAL METHODS FOR PROTEIN STRUCTURE DETERMINATION - A screening method for determining secondary structures of a protein or polypeptide without performing computer simulation, is provided. The screening method is based in part on the interaction between the electrostatic forces and the electrostatic displacement forces in the protein, and makes use of a set of computational conditional statements. The screening method includes determining both alpha helix and beta sheet structures based on hydrophobic character and charges of the residues, among other considerations. A method for determining an overall folded structure of a protein using a physics-based simulation method with an initial configuration of the protein prepared according to the secondary structure(s) determined by the screening method, is also provided.01-10-2013
20130013214METHOD AND APPARATUS FOR CORRELATING LEVELS OF BIOMARKER PRODUCTS WITH DISEASE - In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies.01-10-2013
20120150448Modular Analyte Measurement Systems, Modular Components Thereof and Related Methods - Presented herein is a modular analyte measurement system having a replaceable strip port module that releasably connects and operably couples with an analyte meter. Embodiments of the present invention also relate to modular components of the analyte measurement system. In one aspect, there is provided a replaceable strip port module having a strip port and electrical interface for removably and electrically coupling with an analyte meter. In another aspect, there is provided an analyte meter that includes a processor and electrical interface for removably and electrically coupling with replaceable strip port modules. Methods of configuring the analyte measurement system and methods of determining an analyte meter with the analyte measurement system are also provided.06-14-2012
20130018590EVENT DOSIMETER DEVICES AND METHODS THEREOF - A dosimetry device includes at least one sensor in a housing and a dosimetry processing device with a memory. The dosimtery processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the sensor; storing the readings; conducting an analysis of the stored readings to determine an injury risk assessment; and outputting at least one of the conducted analysis of the determined injury risk assessment or the stored readings.01-17-2013
20130018589DATA CONVERSION IN ECG TECHNIQUESAANM Yuk; JongtaeAACI RedmondAAST WAAACO USAAGP Yuk; Jongtae Redmond WA US - A computer-implementable method includes generating a first set of input signals representing an X-lead ECG apparatus, generating a second set of input signals based on the first set and representing a Y-lead ECG apparatus, and generating to a display device a set of ECG traces and/or a diagnosis of acute myocardial infarction based on the second set. X and Y are integer values and Y is greater than X.01-17-2013
20130018595COPD EXACERBATION DETECTION USING SPUTUM ANALYSIS - Subject of the invention is the diagnosis and/or monitoring of chronic obstructive pulmonary disease based on sputum rheology. The complex modulus i.e. the viscous modulus and the elastic modulus of sputum is measured and assessed in respect of chronic obstructive pulmonary disease.01-17-2013
20130018594APPARATUS AND METHOD FOR IDENTIFYING SECONDARY STRUCTURE OF PROTEIN USING ALPHA CARBON COORDINATESAANM Cho; Kwang-HwiAACI SeoulAACO KRAAGP Cho; Kwang-Hwi Seoul KRAANM No; Kyoung-TaiAACI SeoulAACO KRAAGP No; Kyoung-Tai Seoul KRAANM You; Min-JaeAACI SeoulAACO KRAAGP You; Min-Jae Seoul KR - This invention relates to an apparatus and method for identifying the secondary structure of a protein using alpha carbon coordinates. The apparatus includes a pseudo center fixing unit receiving a series of alpha carbon coordinates of amino acid sequences of a target protein so that pseudo centers corresponding to respective alpha carbons are disposed at positions fixed between the respective alpha carbons and alpha carbons adjacent thereto; a helix determination unit determining, based on a dihedral angle and a distance between a preset number of consecutive pseudo centers, whether the secondary structure formed by amino acids corresponding to the consecutive pseudo centers is a helix; and a strand determination unit determining, based on distances between pseudo centers of different pseudo center sequences in a plurality of pseudo center sequences having a preset number of consecutive pseudo centers among pseudo centers other than those corresponding to the helix, whether the secondary structure formed by amino acids corresponding to the pseudo centers of respective pseudo center sequences is a strand. According to this invention, the secondary structure including amino acids corresponding to pseudo centers can be identified based on the dihedral angle or the distance between pseudo centers using pseudo centers fixed between alpha carbons, thus attaining increased accuracy, compared to conventional methods using alpha carbon coordinates.01-17-2013
20130018593MULTI-STAGE, REGRESSION-BASED PCR ANALYSIS SYSTEM - Systems and methods are provided for analyzing data to determine properties of a PCR process or other process exhibiting amplification or growth. Data representing an amplification can be distinguished from data representing a jump or other error. A modified sigmoid function containing a drift term may be used in determining the properties. A multi-stage functional fit of the amplification data can provide increased accuracy and consistency of one or more of the properties. A baseline of the amplification data can be determined by analyzing an integrated area of a first derivative function of the data. A reference quantitation value can also be determined from locations of maxima of different derivative functions of the amplification data, e.g., a weighted average of the maxima locations for the second and third derivatives may be used.01-17-2013
20130018592Systems and Methods for Inter-Population Neurobehavioral Status Assessment Using Profiles Adjustable to Testing Conditions - Systems and methods for inter-population assessment of neurobehavioral status employ neurobehavioral profiles to accommodate differing external conditions. Population profiles and external condition data are provided to a neurobehavioral performance model to determine neurobehavioral status under external conditions. Alternatively, neurobehavioral performance values may be retrieved from the profile when such values are stored in conjunction with external condition data. Comparisons of the resulting neurobehavioral status(es) are then determined, and may comprise without limitation one or more of: performance deltas, statistical parameter differences, rankings, above/below performance threshold determinations, pass/fail indicators, and countermeasure recommendations. Populations may comprise pluralities, individuals and empty (“null”) sets. Comparisons may also pertain to one or more relevant times of interest and one or more sets of testing conditions. Fields of application include (without limitation) operational and military fatigue management, medical diagnosis and treatment, fatigue countermeasure training and individualization, sleep research, academic and scientific research, and/or the like.01-17-2013
20130018591FAST TOMOGRAPHIC MICROWAVE IMAGING - Microwave imaging equipment utilizing an array of antennas operated to collect electromagnetic field information for a material being imaged. Image processing method and apparatus use the discrete dipole approximation (DDA) and drastically reduce the time required to process the measured data and estimate the properties of the material. Prior to interrogating the material, interaction matrices are generated and stored for future DDA calculations. The interaction matrices relate to the interaction between the antennas, the operating frequency, the background medium, and the location of the discretizing dipoles. An initial guess of the material properties is made and the resultant field is estimated. These results are compared to the measured results and incremental changes in the material property are computed. The updated material properties are used to recalculate the field. Comparison of the field to the measured field and updating of the material properties continues until an end criterion is satisfied.01-17-2013
20110161013METHOD FOR DETERMINING HEAT BOUNDARY VALUE CONDITIONS OF RED BLOOD CELLS IN THE NEIGHBORHOOD OF MYOCARDIUM - A computer-implemented method for determining heat boundary value conditions of red blood cells neighboring a myocardium pertaining to the left ventricle of a heart. The method comprises dividing the myocardium into a plurality of myocardial samples wherein, each sample comprises a plurality of myocardial surfaces. The method further comprises quadratically representing each myocardial surface at apical, mid, and basal positions wherein the apical and basal positions are the positions at which the contraction of the heart begins and ends during systole. Further, parameterized forms of lines along x-y, x-z, and y-z axes are formulized; the parameterized forms of lines within which each myocardial surface at each position moves. Upon formulizing the parameterized forms of lines, the radial, longitudinal, and circumferential components of the magnitude of heat generated or lost at each myocardial surface at each position are obtained, following which, the radial, longitudinal, and circumferential components of the magnitude of heat transferred from each myocardial surface at each position to the red blood cells in the corresponding neighborhood are obtained.06-30-2011
20130024126METHOD AND A CORRECTION SYSTEM FOR CORRECTING TRACER-UPTAKE MEASUREMENTS - This invention relates to a method and a correction system for correcting tracer-uptake measurements for patient specific variations in the tracer-uptake. Input data are received about the patient and subsequently it is determining whether the received input data include tracer-impact data that impact the tracer-uptake measurements for the patient. In case the tracer-impact data are included in the input data a comparing is performed where the tracer-impact data are compared with pre-stored reference data that have associated thereto a correction indicator indicating an amount of deviation of the tracer-uptake measurement due to the tracer-uptake dependent data. The correction indicator of the pre-stored reference data that match with the tracer-impact data is then used to correct the tracer-uptake measurements for the patient.01-24-2013
20130024125STATISTICAL ANALYSIS OF MEDICAL THERAPY OUTCOMES - A method for evaluating a medical therapy with a computing device comprises accessing a data storage system to obtain baseline characteristics for a population of patients who each receive a medical therapy, accessing baseline characteristics and one or more post-therapy outcomes for a subset of the population, and accessing an association between the baseline characteristics and the post-therapy outcomes in the subset. The method further includes modeling the distribution of the post-therapy outcomes in the population based on the distribution of the post-therapy outcomes in the subset and further based on a comparison of the distribution of the of the baseline characteristics in the subset with the distribution of the baseline characteristics in the population, and storing an indication of the modeled distribution of the post-therapy outcomes in the population of patients on the data storage system.01-24-2013
20130024129DETECTING CHEMICAL COMPONENTS FROM SPECTROSCOPIC OBSERVATIONS - Embodiments disclosed herein may include methods and systems capable of estimating the underlying concentrations of chromophores in a sample. The photon scattering and absorption model may be based on Laplace and stable distributions, which may reveal that measurements in diffuse reflectance may follow a Beer-Lambert and Kohlrausch-Williams-Watts (KWW) product. This Beer-Lambert portion of the product may dominate in high absorption sample areas, while the KWW portion of the product may dominate in low absorption sample areas.01-24-2013
20130024128METHOD FOR ESTIMATING A BLOOD SUGAR CONDITION - A blood sugar condition is estimated by measuring a urine sugar value, discriminating whether it is less than a discriminating method classification boundary value, when it is less, obtaining an averaged value of measured urine sugar values during a past predetermined period of time, measured at the same time of day as the latest measurement, calculating the difference between the averaged and measured urine sugar values, when the difference is not less than a positive discriminating reference difference, discriminating as being a blood sugar value decrease, when the measured value is not less than the discriminating method classification boundary value, obtaining an averaged value of all measured values during the past predetermined period of time, calculating a ratio between the measured and averaged values, and, when the ratio is not greater than a first discriminating reference ratio, discriminating as being the blood sugar value decrease.01-24-2013
20130024127DETERMINATION OF SOURCE CONTRIBUTIONS USING BINOMIAL PROBABILITY CALCULATIONS - This invention relates to calculation of percent contribution of data from a major source and a minor source in a sample.01-24-2013
20130024123METHODS AND SYSTEMS FOR DETERMINING PHYSIOLOGICAL PARAMETERS USING TEMPLATE MATCHING - A patient monitoring system may be configured to use template matching in determining physiological parameters. A physiological signal may be monitored, and a wavelet transform may be performed. The wavelet transform, or parameters derived thereof such as energy distribution or relative phase difference, may be compared with one or more templates using template matching. Templates may be based on, for example, physiological data, mathematical models, or look-up tables, and may be pre-computed and stored. Physiological parameters may be determined based on the template matching results. Scale variability, confidence metrics, or both, may be used to aid in determining the physiological parameter.01-24-2013
20130024124SYSTEMS, METHODS, AND APPARATUS FOR PREVENTING RECIDIVISM - Systems, apparatus, methods and articles of manufacture provide for assessing a likelihood of recidivism for persons (e.g., patients, injured workers). In some embodiments, information such as claim information, employment information, personal information, and/or medical information, may be used in determining a recidivism score or other indication or measure of a likelihood of recidivism.01-24-2013
20130173170WEB-BASED PLATFORM FOR ANALYZING LARGE-SCALE TOF-SIMS DATA AND METHOD THEREOF - Disclosed is a web-based platform for analyzing large-scale TOF-SIMS data and a method thereof. The web-based platform for analyzing large-scale TOF-SIMS data according to the present invention comprises: a communication unit for providing a connected user terminal with a web page and receiving a file for analyzing the TOF-SIMS data from the user terminal via the provided web page; a processing unit for analyzing the TOF-SIMS data using the received file and providing the user terminal with information created based on a result of the analysis via the communication unit; and a storage unit for storing the information created based on the result of the analysis. Through the platform, the present invention may provide a web-based tool that can be used in an automated analysis method.07-04-2013
20130173174APPARATUS, METHOD, AND SYSTEM FOR ACCURATE ESTIMATION OF TOTAL ENERGY EXPENDITURE IN DAILY ACTIVITIES - An apparatus, article, and system, the apparatus including a housing, a 3-axis accelerometer contained in the housing, a medium storing program instructions, and a processor to execute the program instructions stored in the memory to receive a signal from the 3-axis accelerometer indicative of a user's activities, extract features from the received signals, classify the extracted features into a plurality of activity types, determine a total energy expenditure based on the classification of the extracted features; and provide a report of the total energy expenditure.07-04-2013
20080319677Systems and Methods for Designing Molecules with Affinity for Therapeutic Target Proteins - The present invention provides methods for designing molecules with affinity for target proteins. More particularly, the present invention provides systems and methods for docking fragment molecules to target protein binding sites. The systems and methods are useful for designing active molecules in drug discovery. Methods of this invention can be implemented in a computer system and may be embodied as computer code in a computer readable medium.12-25-2008
20090018777Systems and Methods for Predicitng Ligand-Protein Binding Interactions - The present invention relates to systems and methods for determining a candidate molecule's ability to bind a target protein comprising calculating a score for the candidate molecule, wherein the score is a function of a position of the candidate molecule relative to a field of distribution densities on a three-dimensional target protein structure. The systems and methods are useful for designing active molecules in drug discovery. Methods of this invention can be implemented in a computer system and may be embodied as computer code in a computer readable medium.01-15-2009
20080234944Method and Apparatus for Subset Selection with Preference Maximization - A method and apparatus for determining a subset of measurements from a plurality of measurements in a genetic algorithm is disclosed. The method comprising the steps of determining a fitness measure for each sub-set of the measurements, wherein each measurement has an associated fitness measure and selecting the subset of measurements having the lowest fitness measure (09-25-2008
20080221803Methods of predicting treatment outcome in chronic periodontitis patients - The invention is a new method for predicting when subjects having chronic periodontitis will fail or succeed conventional standard therapy. The method uses measures of the plaque cadaverine fraction with additional measurements including age, fraction of gingival margins that bleed on probing (BOP), and clinical attachment level (CAL in mm) to calculate discriminant function equations for calculating individual score sets. When CF is above 0.45 in periodontitis patients, it is predicted that most available therapies with which the periodontitis patient can be treated will fail, including a conventional standard treatment or an aggressive combined antibiotic/oral hygiene therapy.09-11-2008
20080221805MULTI-CHANNEL LOCK-IN AMPLIFIER SYSTEM AND METHOD - A multi-channel lock-in amplifier system for use in cell analysis is disclosed. The system may include a cartridge having one or more flow cells with each flow cell containing a cell for analysis. An oscillating electric field may be applied across each flow cell at one or more excitation frequencies in order to detect the responses of the cell either in electrical impedance at frequencies that provide a non-linear response.09-11-2008
20080221804System of Processing Patient Medical Data - A system is described for assisting in the interpretation of medical images by making available information derived from other tests such as in vitro testing. In a preferred embodiment, an in vitro diagnostic testing device is integrated with a scanner such as a Positron Emission Tomography (PET) device so that both types of data can be simultaneously acquired and presented to the diagnosing physician.09-11-2008
20080221802Method of Proteome Analysis for Phosphorylated Protein - A method for detecting plural types of phosphorylated proteins in a sample, wherein a database consisting of data regarding plural types of proteins in the sample is used; and a method for purifying phosphorylated proteins using an immobilized metal carrier or a titania carrier, wherein a solution containing acetonitrile in a range of 40% (v/v) or greater but 60% (v/v) or less is used.09-11-2008
20130144537Real Time Assessment During Interactive Activity - A solution for adjusting an interactive activity is provided. While a person is engaged in an instance of the interactive activity, direct measurement data corresponding to the person is received. The direct measurement data is used to assess at least one aspect of a response of the person to the instance of the interactive activity. Assessment data corresponding to the at least one aspect of the response is provided for use in adjusting at least one aspect of the interactive activity.06-06-2013
20130144538Clot Protection and Detection Algorithm for Activated Clotting Time Testing - Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots.06-06-2013
20130144539Embedded Data DNA Sequence Security System - An embedded data DNA sequence security system which utilizes an embedded data DNA sequence to differentiate each of a plurality of identifiable objects.06-06-2013
20130173171DATA-CAPABLE STRAPBAND - Embodiments relate to a band including sensors to detect motion and a motion matcher configured to capture data representative of the motion. The motion matcher can also identify an activity associated with the motion. The band transitions from one mode of operation to another as a function of the activity. Further, the band can include a controller and a memory storing data representing motion patterns. The controller is configured to select a mode of operation as a function of a motion pattern.07-04-2013
20130173172CONSIDERATION OF EVIDENCE - In many situations, particularly in forensic science, there is a need to consider one piece of evidence against one or more other pieces of evidence. For instance, it may be desirable to compare a sample collected from a crime scene with a sample collected from a person, with a view to linking the two by comparing the characteristics of their DNA, particularly by expressing the strength or likelihood of the comparison made, a so called likelihood ratio. The method provides a more accurate or robust method for establishing likelihood ratios through the definitions of the likelihood ratios used and the manner in which the probability distribution functions for use in establishing likelihood ratios are obtained. The methods provide due consideration of stutter and/or dropout of alleles in DNA analysis, as well as taking into consideration one or more peak imbalance effects, such as degradation, amplification efficiency, sampling effects and the like.07-04-2013
20130173175METHOD AND APPARATUS FOR MEASURING BIOMETRICS OF OBJECT - A method for measuring biometrics of an object includes receiving an image of an object, modeling the object to identify a portion of the object, and measuring biometrics of the object based on a modeling result the object.07-04-2013
20130173173SYSTEMS AND METHODS FOR STEP DISCONTINUITY REMOVAL IN REAL-TIME PCR FLUORESCENCE DATA - Systems and methods for removing jump discontinuities in growth data are provided. A first approximation to a received data set is determined by applying a non-linear regression process to a non-linear function that models the data set to determine parameters, including a step discontinuity parameter. A second approximation to the data set is also determined by applying a regression process to a second non-linear function to determine parameters, including a step discontinuity parameter, of the second function. One of the approximations is selected based on an information coefficient determined for each of the approximations. If a confidence interval for the step discontinuity parameter includes zero, no correction is made, and if includes zero, then a correction is made. For a correction, the portion of the data curve prior to the step change is replaced with appropriate portion of the selected approximation to produce a shift-corrected data set.07-04-2013
20120253685TESTING PROCESS - A method of determining an inclusive residual risk that a pregnancy is affected by at least one phenotypic disorder included in a disorder set is provided. The method includes calculating a prior risk for a disorder set, calculating posterior risks for the individual disorders or groups of disorders in the disorder set that can be screened for and/or diagnosed prenatally, and calculating an inclusive residual risk for the disorder set by combining the prior risks for disorders for which no tests have been performed and the individual posterior risks.10-04-2012
20110270531SYSTEM FOR SELECTING PLANTS FROM AMONG A POPULATION OF PLANTS - Provided is a system (11-03-2011
20110270530COMBINED NATRIURETIC PEPTIDE ASSAYS - The present invention relates to methods for the diagnosis and evaluation of BNP-related diseases. In particular, patient test samples are analyzed for the presence and amount of a plurality of natriuretic peptides, and a combined natriuretic peptide result is used as a diagnostic marker.11-03-2011
20130138356Method And System For Detecting And Removing EEG Artifacts - A method and system for detecting and removing EEG artifacts is disclosed herein. Each source of a plurality of sources for an EEG signal is separated for a selected artifact type. Each source of the plurality of sources is reconstituted into a recorded montage and an optimal reference montage for recognizing the selected artifact type of each source. The sources with artifacts are removed and the remaining sources are reconstituted into a filtered montage for the EEG signal.05-30-2013
20130090859METHODS AND SYSTEMS FOR GENOME-SCALE KINETIC MODELING - Embodiments of the present invention generally relate to the construction, analysis, and characterization of dynamical states of biological networks at the cellular level. Methods are provided for analyzing the dynamical states by constructing matrices using high-throughput data types, such as fluxomic, metabolomic, and proteomic data. Some embodiments relate to an individual, while others relate to a plurality of individuals.04-11-2013
20130096836AUTOMATED TOTAL BODY ALBUMIN ANALYZER - A computer-based method for automatically determining total body albumin of a living being based on the calculated intravascular albumin, the calculated observed ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time, and the baseline of expected ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time.04-18-2013
20130096838Gene Splicing Defects - Predicting the effect of a mutation in a nucleic acid sequence on splicing is accomplished by determining the distance between at least two nucleic acid sequence positional distributions and providing a prediction of impact on splicing function based on at least the distance. A low distance indicates there is little or no difference in splicing function compared to a normal control. A high distance indicates a difference in splicing function. Related apparatus, systems, techniques and articles are also described.04-18-2013
20130096837AUTOMATED BLOOD ANALYZER - An automated blood analyzer that analyzes blood of a living being including one or more sample carriers that hold samples of blood of a living being, each sample having been withdrawn from the living being at a different point in time after the living being was injected with radio-labeled albumin, means for calculating a set of data points representing blood volume of the living being at the one or more points in time after the living being was injected with the radio-labeled albumin based on detected counts of the radio-labeled albumin in the samples of blood, wherein the automated blood analyzer uses the set of data points for further analysis of the blood of the living being, and a quality control module that at least one of calibrates the means for calculating or verifies that the means for calculating operates within predetermined parameters.04-18-2013
20130096844DETECTION OF CONDITIONS FROM SOUND - Disclosed are various systems, methods, and programs embodied in a computer-readable medium for sound analysis. The sound analysis involves transforming a sound print into a frequency domain in a memory to generate a frequency spectrum. A plurality of signatures are identified in the frequency spectrum. Also, a plurality of frequency ranges associated with the signatures are identified in the sound print. The frequencies associated with a physiological profile are cross-referenced with the frequency ranges to determine if the physiological profile is applicable to the sound print.04-18-2013
20130096841IDENTIFICATION OF DNA FRAGMENTS AND STRUCTURAL VARIATIONS - Various short reads can be grouped and identified as coming from a same long DNA fragment (e.g., by using wells with a relatively low-concentration of DNA). A histogram of the genomic coverage of a group of short reads can provide the edges of the corresponding long fragment (pulse). The knowledge of these pulses can provide an ability to determine the haploid genome and to identify structural variations.04-18-2013
20130096839SEIZURE DETECTION METHODS, APPARATUS, AND SYSTEMS USING A WAVELET TRANSFORM MAXIMUM MODULUS ALGORITHM - Methods for detecting a seizure, by use of a wavelet transform maximum modulus (WTMM) algorithm applied to body data. A non-transitive, computer-readable storage device for storing data that when executed by a processor, perform such a method.04-18-2013
20130096842GLUCOSE TOLERANCE ANALYZER, GLUCOSE TOLERANCE ANALYZING SYSTEM, AND STORAGE MEDIUM - A glucose tolerance analyzer comprising: an accepting section configured to accept inputs of information regarding a type of food or drink ingested by a subject, information regarding an intake amount of the food or drink, and information regarding an amount of glucose in the subject after the ingestion of the food or drink; an output section configured to output an analysis result of glucose tolerance; and a controller configured to: calculate a reference value for analyzing glucose tolerance of the subject based on the accepted information regarding the type of the food or drink ingested by the subject and the information regarding the intake amount of the food or drink, and based on a predetermined index regarding blood glucose increase due to food or drink; analyze the glucose tolerance of the subject based on the accepted information regarding the amount of glucose and based on the calculated reference value; and control the output section to output an obtained analysis result as an analysis result of glucose tolerance.04-18-2013
20130103320METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS - Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.04-25-2013
20130179088SYSTEM AND METHOD FOR MEASURING RELATIVE LEG POSITIONS OF AN UNGULATE07-11-2013
20130179087Methods and Systems for Determining, Monitoring, and Analyzing Personalized Response Variables Using Brain Wave Frequency Data and Interactive Multimedia Display - A computer-implemented method for monitoring one or more response variables in response to a media segment using brain wave frequency data includes displaying a media segment to a user. The media segment includes one or more embedded flags to flag one or more positions of the media segment. The method further includes acquiring brain wave frequency data of the user, acquiring amplitude data of the acquired brain wave frequency data in one or more frequency bands; and determining one or more response variables in response to the acquired amplitude data of the acquired brain wave frequency data correlating to flagged positions of the media segment.07-11-2013
20130179086SYSTEMS AND METHODS FOR THE DETERMINATION OF A COPY NUMBER OF A GENOMIC SEQUENCE - System and methods for the determination of a copy number of a target genomic sequence; either a target gene or genomic sequence of interest, in a biological sample are described. Various methods utilize a model drawn from a probability density function (PDF) for the assignment of a copy number of a target genomic sequence in a biological sample. Additionally, the methods provide for the determination of a confidence value for a copy number assigned to a sample based on attributes of the sample data. Additionally, various embodiments of an interactive graphical user interface (GUI) may provide an end-user with ready analysis of large sets of data representing a plurality of samples. In various embodiments of an interactive GUI, an end-user may be provided with a synchronized display of tabular and graphical sample data determined by an initial analysis according to a statistical model of a PDF. Such a synchronized display may enable an end-user to readily identify sample data for a subsequent analysis based on user input.07-11-2013
20130179085PRECISION PHENOTYPING USING SCORE SPACE PROXIMITY ANALYSIS - Methods are provided for determining the level of perturbation of a phenotype in an organism using a multivariate statistical analysis. The method comprises a first step of collecting at least one measurement from at least one control group of organisms and at least one experimental group of organisms to produce a set of data. The method further comprises a second step of using a processor to conduct a multivariate statistical analysis on the set of data to determine the level of perturbation of a phenotype or trait of interest in the experimental group of organisms. Methods are further provided for selecting a group of organisms based on the multivariate statistical analysis.07-11-2013
20130179084HAND-HELD TEST METER WITH SIGNAL RECOVERY BLOCK - A hand-held test meter (“HHTM”) for use with an analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing, an electrical signal receiving block, a signal recovery block and a microcontroller block, all of which are disposed in the housing. The electrical signal receiving block is configured to receive an electrical signal from an analytical test strip inserted in the HHTM that has been distorted into a distorted electrical signal. In addition, the signal recovery block and microcontroller block are configured to recover the electrical signal from the distorted electrical signal by generating a recovered electrical signal based on a predetermined recovered electrical signal frequency, a recovered electrical signal amplitude estimated from the distorted electrical signal, a recovered electrical signal offset estimated from distorted electrical signal and a recovered electrical signal phase determined using a least sum squares calculation.07-11-2013
20130124099SECONDARY STRUCTURE DEFINING DATABASE AND METHODS FOR DETERMINING IDENTITY AND GEOGRAPHIC ORIGIN OF AN UNKNOWN BIOAGENT THEREBY - The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.05-16-2013
20130124098Body Self-Shielding Background Compensation for Contamination Monitors Based on Anthropometrics - A system and method for correcting, based on a monitored subject's height and thickness, the net count rate value of a whole-body surface contamination monitoring device. The device includes a height detection means for determining the height of a subject being monitored, and a thickness detection means for determining the thickness of at least a portion of the body of the subject being monitored. The net count rate is based on site calibration factor data and self-shielding factor data, wherein both types of factor data consider the determined height and thickness.05-16-2013
20130131994METHOD AND APPARATUS FOR MOBILE DISASTER VICTIM IDENTIFICATION - Mobile telecommunications or personal computing apparatus may be specially programmed for predicting whether an unknown biological specimen of an individual to be identified originates from or is related to a member of a particular family. The apparatus may comprise an input device including a barcode reader and a virtual touch screen keyboard whereby DNA profile or mass spectrometry test data may be entered among other data for an individual to be identified, for example, a missing person, victim, crime perpetrator or other unknown individual in hypothetical relationship to another individual or to a family pedigree of typed family members. The typed family pedigree in relation to the individual to be identified in hypothetical relation may be displayed on an output display of the apparatus including at least two different profile typing indicators for each displayed member of the pedigree.05-23-2013
20130131993ITERATIVE TIME SERIES MATRIX PATTERN ENHANCER PROCESSOR - A method and system for analyzing data about a physiological occurrence is described herein. The method includes executing a first software element to produce a result set with physiological data related to a set of patients. The method also includes detecting a physiological occurrence within the result set. Furthermore, the method includes generating a second software element to increase the accuracy of the first software element based on the physiological occurrence and the physiological data from the set of patients.05-23-2013
20130131992SYSTEM FOR MAGNETIC RESONANCE SPECTROSCOPY OF BRAIN TISSUE FOR PATTERN-BASED DIAGNOSTICS - A system and method for preprocessing magnetic resonance spectroscopy (MRS) data of brain tissue for pattern-based diagnostics is disclosed. The MRS preprocessing system includes an MRS preprocessing module that executes an operation that normalizes MRS spectrum data, recalibrates and scales the normalized MRS spectrum data, and then renormalizes the scaled MRS spectrum data. The resulting preprocessed MRS data is used to assist in identifying abnormalities in tissues shown in MRS scans.05-23-2013
20110060532METHODS AND COMPOSITIONS FOR THE ASSESSMENT OF DRUG RESPONSE - The present invention provides methods for predicting or determining a subject's response to an antiplatelet agent, and methods for determining a subject's suitability to a treatment regime or intervention for a disease associated with platelet aggregation, using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's response to an antiplatelet agent. Nucleotide probes and primers, kits, and microarrays suitable for such assessment are also provided03-10-2011
20100280758 METHOD AND AN APPARATUS FOR DETERMINING NUCLEOTIDE SEQUENCE, AND A COMPUTER PROGRAM PRODUCT TO BE EXECUTED BY THE APPARATUS - A method for determining nucleotide sequence encompasses (a) injecting a solution containing a sample nucleic acid into a chip cartridge, (b) detecting first detection, second detection, and control signals through electrodes on the chip cartridge, (c) calculating a first difference between a mean value of the control signals and a mean value of the first detection signals, and dividing the first difference by the mean value of the control signals to define X, (c) calculating a second difference between the mean value of the control signals and a mean value of the second detection signals, and dividing the second difference by the mean value of the control signals to define Y, (d) calculating an angle between a positive X-axis and a vector from origin to a point (X, Y), and (d) comparing the angle with angle judgment criteria so as to identify a genotype of the sample nucleic acid.11-04-2010
20130103321Selection of Preferred Sample Handling and Processing Protocol for Identification of Disease Biomarkers and Sample Quality Assessment - The subject invention relates to methods for obtaining biological samples of improved quality. It encompasses the identification of markers or proteins in biological samples that are altered due to variations in sample collection, handling and processing. They are also useful for correcting variations in measured results for disease biomarkers. Further, they can permit the rejection of samples or groups of samples as necessary if it is determined that their collection method was not in accordance with the predetermined protocol. Other advantages useful to the skilled artisan are described herein.04-25-2013
20080201081Analytical Method and Apparatus - A method for analysing function of a biosystem (08-21-2008
20110224914CONSTRAINED PROCESSING TECHNIQUE FOR AN IMPEDANCE BIOSENSOR - A system for determining impedance includes receiving a time varying voltage signal from a biosensor and receiving a time varying current signal from the biosensor. The time varying voltage signal and the time varying current signal are transformed to a domain that represents complex impedance values. Parameters based upon the impedance values are calculated using at least one constrained pole set to a DC value.09-15-2011
20110231108PROTEIN STRUCTURE ANALYSIS - Techniques for analyzing one or more protein structures. In one aspect of the invention, the technique comprises the following steps. A normalized second-order hydrophobic moment is determined for a protein structure. The normalized second-order hydrophobic moment is then used for analysis of the protein structure. A scoring function in accordance with the normalized second-order hydrophobic moment for the protein structure may be determined. A score for the protein structure may then be generated using the scoring function. The scoring function may represent an integral of the normalized second-order hydrophobic moment. The scores may be generated for a plurality of protein structures. The scores generated for the plurality of protein structures may then be compared.09-22-2011
20110231102METHOD, SYSTEM AND SOFTWARE ARRANGEMENT FOR COMPARATIVE ANALYSIS AND PHYLOGENY WITH WHOLE-GENOME OPTICAL MAPS - The present invention provides a method for organizing genomic information from multiple organisms. In one embodiment of the invention, phylogenetic trees can be constructed for the organisms. The method of the present invention is termed CAPO, Comparative Analysis and Phylogeny with Optical-Maps. Optical maps of organisms are obtained and phylogeny between the organisms is determined by optical map comparison and bipartite graph matching between the organisms, as, for example, computed by a stable marriage algorithm.09-22-2011
20100286927Data Dependent Acquisition System for Mass Spectrometry and Methods of Use - Methods, systems and computer readable media for data dependent acquisition are provided. Using data representing isotopic clusters identified from a mass spectrum of a sample, a data dependent acquisition computer system is used to calculate a purity value for each isotopic cluster of interest in the mass spectrum, where each isotopic cluster of interest is identified within an isolation window used to obtain the data. A selection score based on the purity value is then calculated for each isotopic cluster of interest. The selection scores are then rank-ordered, and one or more of the highest selection scores are selected to identify those isotopic clusters, which correspond to the selected selection scores, for further processing.11-11-2010
20100286926COMBINATIONS OF POLYMORPHISMS FOR DETERMINING ALLELE-SPECIFIC EXPRESSION OF IGF2 - Combinations of SNPs and reagents for detecting such SNPs, as well as methods of detecting IGF loss-of-imprinting as provided.11-11-2010
20100286925OLIGOMER SEQUENCES MAPPING - Mapping oligomer sequences includes receiving a set of related oligomer sequences, applying one or more key patterns derived from a set of oligomer sequence relationships to obtain one or more keys that are consistent with the set of related oligomer sequences, and locating the one or more keys in an index configured to map a plurality of possible keys to their respective candidate and/or validated locations in a reference.11-11-2010
20100286924POLYMORPHISM DETECTION - The present invention generally provides a rapid efficient method for analyzing polymorphic or biallelic markers, and arrays for carrying out these analyses. In general, the methods of the present invention employ arrays of oligonucleotide probes that are complementary to target nucleic acids which correspond to the marker sequences of an individual. The probes are typically arranged in detection blocks, each block being capable of discriminating the three genotypes for a given marker, i.e., the heterozygote or either of the two homozygotes. The method allows for rapid, automatable analysis of genetic linkage to even complex polygenic traits11-11-2010
20100286923Computer-assisted means for assessing lifestyle risk factors - The present invention relates to methods of assessing disease susceptibility associated with dietary and lifestyle risk factors. The invention provides for analysis of alleles at loci of genes associated with lifestyle risk factors, and the disease susceptibility profile of an individual is determined by reference to datasets which further match the risk factor with lifestyle recommendations in order to produce a personalized lifestyle advice plan.11-11-2010
20110246079INDIVIDUAL 5-FLUOROURACILE DOSE OPTIMIZATION IN FOLFOX TREATMENT - The present invention belongs to the field of improved personalized medicine. More precisely, the present invention relates to a method for progressively optimizing the 5-FU dose administered by continuous infusion in patients treated by a FOLFOX regimen or a similar regimen, based on the 5-FU plasmatic concentration measured during the previous 5-FU continuous infusion and on a herein described decision algorithm. The present invention also relates to a method for treating a cancer patient in which the 5-FU dose administered in continuous infusion in each FOLFOX or similar treatment cycle is optimized using the decision algorithm according to the invention.10-06-2011
20130151165Computer Systems for Treating Diseases - The present invention relates to computer-implemented methods and system for analysing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analysing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.06-13-2013
20130151162DRUG DELIVERY DEVICE - Drug delivery devices are described that include sensors and processing circuitry that can detect operating events, such as flow rates and drug delivery, in various types of inhalers, such as dry powder inhalers, metered dose inhalers, nasal inhalers and nebulisers. The information determined by the processing circuitry can be used to provide feedback to the user or can be stored or transmitted for subsequent analysis. This information can be used to improve clinical trials by providing information about the way in which the inhalers under test are being used.06-13-2013
20130151163METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW - Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.06-13-2013
20130151164Systems and Methods for Analyzing Microarrays - The present invention discloses methods and systems for analyzing microarray data. The method includes the general steps of providing microarray data, normalizing the data using a least trimmed squares regression, and then analyzing the normalized microarray data to obtain a desired result such as an expression profile. There is also disclosed a method of subdividing an array into subarrays before normalization. This approach provides a method for improving measurement accuracy and salvaging array data from arrays containing minor defects. Also disclosed is a Probe-Treatment-Reference (PTR) model for streamlining normalization and summarization of microarray data by allowing multiple references. Other aspects of the present invention include computer systems and computer readable media encoding methods of the present invention.06-13-2013
20130151166Reduction Of Classification Error Rates And Monitoring System Using An Artificial Class - Systems and methods for enhancing the accuracy of classifying a measurement by providing an artificial class. Seizure prediction systems may employ a classification system including an artificial class and a user interface for signaling uncertainty in classification when a measurement is classified in the artificial class.06-13-2013
20100299073DIVE COMPUTER FOR A PLURALITY OF USERS - Dive computer with at least one measuring device for detecting measured variables, at least one memory device, at least one computing device, at least one data transmitter, and one display device for displaying information. The memory device has at least one first area and at least one second area in which data are stored that are allocated to at least one first or at least one second user. There is also a selector for selecting the user to whom the data currently detected by the measuring device are allocated.11-25-2010
20090132172METHODS FOR DETECTING AND DIAGNOSING LOW BONE MASS DENSITY - The invention encompasses methods of detecting and diagnosing low bone mass density. The method comprises, in part, obtaining nucleic acid expression data from a plurality of nucleic acid sequences, wherein at least one nucleic acid sequence is selected from the group consisting of ESR1, MAPK3, MECP2, PSTPIP1, SLA, STKL1, WNK1, and ZNF446.05-21-2009
20130096843Portable Monitoring Devices and Methods of Operating Same - A portable activity monitoring device comprising a housing having a physical size and shape that is adapted to couple to the user's body, a motion sensor to detect user motion and, in response thereto, to generate data which is representative of motion of the user, an altitude sensor to detect a change in user altitude and, in response thereto, to generate data which is representative of the change in altitude of the user, processing circuitry to calculate activity metrics of the user, wherein the processing circuitry: (i) calculates a motion metric using the motion data, (ii) calculates an altitude metric using the altitude data, and (iii) calculates at least one sleep metric of the user. In certain embodiments, the processing circuitry may automatically determine a sleep mode of the user using the motion data and calculate at least one user sleep metric.04-18-2013
20100070185REAL-TIME PCR ELBOW CALLING BY EQUATION-LESS ALGORITHM - Systems and methods for determining a transition value in a sigmoid or growth curve, such as the end of the baseline region or the elbow value or Ct value of a PCR amplification curve. Numerical determinations of the second derivatives and curvature values of a PCR data set are made. A Gaussian Mixture Model (GMM) function with parameters determined using a Levenberg-Marquardt (LM), or other, regression process is used to find an approximation to the second derivative values and to the curvature values, where the maximum values of the numerically determined second derivative values and/or curvature values are used as initial conditions for parameters of the GMM function. The determined parameters provide fractional Ct values. The Ct value(s) are then returned and may be displayed or otherwise used for further processing.03-18-2010
20100318301METHOD AND SYSTEM FOR ASSESSING IMMUNE SYSTEM RESPONSE - A method and system for determining the extent to which a patient will respond to a therapeutic regimen by assessing how that regimen will impact the functioning of a patient's immune system. An extent to which a patient will respond to a therapeutic regimen may be assessed based on a set of values for measurable parameters that relate to one or more characteristics of the patient's immune system, and receptor-ligand binding and trafficking characteristics of the patient's immune system, as well as other optional parameters and characteristics of the immune system. A mathematical model of the immune system is provided and may be implemented to predict immune system response, as well as identify parameters that have a greatest impact on predicting immune system response.12-16-2010
20100318300Method for Object Recognition - A method for recognizing an object that has a plurality of expressions of abstract object characteristics, and is associated with an object characteristic class of a hierarchical system of object characteristic classes stored in a first memory. The method includes i) observing at least one location at which the object is presumed to be present, using a plurality of sensors in a sensor population, each of said sensors responding to at least one object characteristic and accordingly emitting a sensor signal; ii) checking whether each of the emitted sensor signals exceeds a specified threshold value for the sensor signals, and accepting sensor signals which exceed the threshold value; iii) pairing combinations of the sensor characteristics, for the accepted sensor signals obtained in ii) to form identification characteristic pairs; iv) comparing the population of identification characteristic pairs obtained in iii) to the object characteristic classes stored in the first memory; and v) identifying the object, based on the object characteristic class, whose object characteristic pairs are identical to the identification characteristic pairs obtained in iii).12-16-2010
20120283957SYSTEMS AND METHODS FOR DETECTING THE PRESENCE OF A BIOLOGICAL STATUS USING PLOT - Systems and methods for identifying Methicillin resistant strains of 11-08-2012
20120283956METHOD AND SYSTEM FOR PREDICTING SELECTIVE CANCER DRUG TARGETS - A method for creating a metabolic map of metabolic reactions by selecting metabolic reactions active in cancer cells. A core set of metabolic reactions occurring in the cancer cells is designated. For each permutation, whether inhibition of the k-th non-core reaction together with inhibition of all previously deleted non-core reactions results in inhibition of any of the core reactions or results in inhibition of the flux of biomass metabolites to biomass is determined. If inhibition of the k-th non-core reaction and inhibition of all previously deleted non-core reactions does not result in inhibition of any core reactions and does not result in inhibition of the flux of biomass metabolites to biomass, then the k-th non-core reaction is deleted from the set of non-core reactions. The number of permutations for which the k-th non-core reaction is not deleted is determined and a metabolic map is then created based on that number.11-08-2012
20120283955METHODS FOR DATA MANIPULATION RELATING TO POLYMER LINEAR ANALYSIS - The invention provides methods for the manipulation and processing of data from direct linear analysis of polymers such as nucleic acids. The resultant processed data is used to identify nucleic acids and/or their biological sources, and/or to identify mutations in the polymers.11-08-2012
20120283954Method for quantitative analysis of complex proteomic data - This invention is a novel method for analysis of data that is produced by test equipment. The preferred embodiment is data produced by liquid chromatography tandem mass spectrometry (LC-MS/MS) equipment, using industry standard methods to generate the initial data from the test equipment. The invention is a method for processing of the data to promptly produce accurate, reliable, and meaningful data that can be used for critical decisions. The unique benefit of the method is to correct the multiple measurement and calculation errors that are inherent in the operation of laboratory equipment. Prior methods result in errors based on circumstances that are difficult to control, accuracy-related errors in machine measurements, and fundamental mathematical errors in the data processing software that used with the laboratory equipment. As an added benefit, this novel method allows comprehensive simultaneous measurement and calculation of correlation of any and all peptide pairs in a single measurement, with the capability to support repeated measurements with changed conditions over time. This novel method allows robust, detailed, and comprehensive measurements of peptide activity and function, which results in substantial improvements over prior methods in accuracy, reliability, and efficiency.11-08-2012
20090076733Water Toxicity Detecting Apparatus and Method Using Sulfur Particles - Provided are a water toxicity detecting apparatus and a method using sulfur particles. The water toxicity detecting apparatus using sulfur particles includes: a reaction container containing microbes, in which externally-supplied sulfur particles and oxygen are reacted to form sulfate ions by the microbes; a water sample inlet through which a water sample is flown into the reaction container; an air inlet through which an air is flown into the reaction container; a first detection unit which detects pH and electrical conductivity of the inflow water sample flown through the water sample inlet; a second detection unit which detects pH and electrical conductivity of the water sample containing the sulfate ions generated in the reaction container; a central processing unit which stores data of the ph and electrical conductivity of the inflow water sample flown through the water sample inlet, adjusts a pumping speed of a pump provided to the water sample inlet and a flow rate of the air, and compares data of the first detection unit with data of the second detection unit to determine presence of toxicity of the water sample; and an outlet through the after-toxicity-test water sample is exhausted from the reaction container.03-19-2009
20130158882METHOD OF FORMING MASS IMAGE - An object of the present invention is to provide a method of comprehensively visualizing a constituent in tumor tissue or the like at a cellular level.06-20-2013
20130184996DEVICE AND METHOD FOR INSULIN DOSING - A device and method of providing instruction to a patient regarding the dosing of insulin is provided.07-18-2013
20130184997Task-Modulated Neurobehavioral Status - Systems and methods for modulating a subject's neurobehavioral status by a task-dependent arousal index are provided. Neurobehavioral status may be measured or model-predicted, and the arousal index reflects the composite effect on the subject's neurobehavioral performance of behavioral, environmental, psychological, and physiological factors of the subject's performing an assigned task. Task arousal index may be selected from a database, provided by user input, or combined in real time from sensor data.07-18-2013
20130184998REPLICATION TIMING PROFILES FOR LEUKEMIA AND OTHER CANCERS - Described is a method for determining that a population of cells are a specific type of leukemic cell based on the replication timing fingerprint for the population of cells.07-18-2013
20110282587COMPUTER READABLE STORAGE MEDIUMS, METHODS AND SYSTEMS FOR NORMALIZING CHEMICAL PROFILES IN BIOLOGICAL OR MEDICAL SAMPLES DETECTED BY MASS SPECTROMETRY - Described herein are computer-readable storage mediums, methods and systems useful for analyzing samples via mass spectrometry. Aspects described herein include methods for normalizing mass spectrometry data that include providing a reference set of mass spectrometry data obtained from a first external standard sample having one or more isotopic standards, wherein the reference set of mass spectrometry data comprises one or more m/z intensity ratios. Methods described herein are useful for reducing errors based on instrument response and ionization efficiencies and improve reproducibility of data from instrument to instrument and from day to day.11-17-2011
20110282585HEPATIC DISEASE-EVALUATING APPARATUS, HEPATIC DISEASE-EVALUATING METHOD, HEPATIC DISEASE-EVALUATING SYSTEM, HEPATIC DISEASE-EVALUATING PROGRAM AND RECORDING MEDIUM - In a hepatic disease-evaluating apparatus, an indicator calculating unit calculates an index indicating the degree of hepatic fibrosis from amino acid concentration data to be evaluated including amino acid concentration value, based on one or more indices of fractional expression having amino acid concentration as variable. A disease state evaluating unit evaluates the disease state of the hepatic disease to be evaluated, based on the index value.11-17-2011
20110301855METHOD OF PROCESSING DATA USING AN ALGORITHM FOR LINEAR EXTENSION OF THRESHOLD IN QUANTITATIVE REAL-TIME PCR DATA - Methods that improve the accuracy of gene expression profiling are provided, and more particularly, methods for quantitative PCT (qPCR) used to determine the level of gene expression or gene copy number in a high-throughput fashion.12-08-2011
20110313681BIOMARKERS FOR PERIPHERAL ARTERY DISEASE - This invention provides biomarkers whose concentrations in blood plasma are associated with the presence or absence of PAD in the patient from whom the plasma sample is taken. The invention also provides biomarkers for distinguishing between PAD patients who are long claudicators and PAD patients who are not. In addition, the invention provides methods for identifying additional biomarkers, methods for detecting the biomarkers in patients, and methods for identifying agents, including pharmaceutical agents, which interact with the biomarkers and are useful for preventing or treating PAD in patients.12-22-2011
20110313680Health Monitoring System - A machine for processing continuous glucose monitoring data and issuing an alert if hypoglycemia is imminent has three modules: (a) a pre-processing module that receives and modulates continuous glucose monitoring data by reducing noise and adjusting for missed data points and shifts due to calibration; (b) a core algorithm module that receives data from the pre-processing module and calculates a rate of change to make a hypoglycemia prediction, and determine if hypoglycemia is imminent; and (c) an alarm mode module that receives data from the core algorithm and issues an audio or visual alert or warning message or a negative feedback signal to an insulin delivery device if hypoglycemia is imminent.12-22-2011
20110313679APPARATUS, METHOD AND COMPUTER-READABLE STORAGE MEDIUM FOR EVALUATING A PHYSIOLOGICAL CONDITION OF A PATIENT - A method is provided that includes receiving measurements of biological elements from a blood sample of a patient. The respective biological elements are managed by the endocrine system, which is organizable in axes including a corticotropic axis, gonadotropic axis, thyreotropic axis and somatotropic axis. The method includes calculating a plurality of indexes as functions of the measurements. The indexes reflect physiological relationships between the biological elements and the hormones that manage the respective biological elements, and at least some of the indexes reflect physiological relationships between hormones across axes of the endocrine system. The method also includes evaluating the indexes by axis of the endocrine system to facilitate identification of one or more dysfunctions capable of participating in the genesis, installation and evolution of a pathology, and thereby formulate a diagnosis of the patient. And the method includes administering a therapy to the patient in accordance with the diagnosis.12-22-2011
20110313678PROBES AND METHODS FOR DETERMINING THE PRESENCE OR ABSENCE OF GENETIC SEGMENTS - A method for determining the presence or absence of a genetic segment of interest, such as an exon, an intron or a promoter, in a DNA-containing sample, and probe sets for use in such methods, including probe sets comprising oligonucleotide probes having nucleotides sequences selected from those of SEQ ID NOS: 1-101.12-22-2011
20110313677METHOD FOR DETERMINING THE LIVER PERFORMANCE OF A LIVING ORGANISM BY THE MEANS OF QUANTITATIVE MEASURING THE METABOLIZATION OF SUBSTRATES - A method for determining the liver performance of a living organism, in particular a human, comprising administering at least one 12-22-2011
20110313676Methods, Systems, and Media for Identifying Transcription Factor Binding Sites - Provided are systems, methods, and media that receive chromosome sequence data; select a first plurality of overlapping octamers from the chromosome sequence data; assign an enrichment score to each of the first plurality of overlapping octamers to produce a first set of enrichment scores; calculate a first average of the first set of enrichment scores; determine whether the first average is above a threshold; select a second plurality of overlapping octamers from the chromosome sequence data; assign an enrichment score to each of the second plurality of overlapping octamers to produce a second set of enrichment scores; calculate a second average of the second set of enrichment scores; determines whether the second average is above the threshold; and output data that indicates that a transcription factor binding site has been identified in connection with at least one of the first plurality of octamers and the second plurality of octamers.12-22-2011
20110313675RAPID DIAGNOSIS OF A DISEASE CONDITION USING INFRARED SPECTROSCOPY - Reliable and rapid diagnostic methods for many functional syndromes (FS) such as Bladder Pain Syndrome/Interstitial Cystitis (IC) are not available. Exemplary embodiments include rapid and accurate methods for diagnosing FS in humans and other mammals using infrared microspectroscopy (IRMS). Exemplary methods utilize Soft Independent Modeling by Class Analogy (SIMCA) to create classification models. Exemplary methods utilize classification models to categorize a subject's condition (e.g., healthy/sick and or flare/remission). Using these classification models, various embodiments enable diagnosis based on spectra data from a blood sample or other biomedical specimen. Exemplary embodiments may be useful for rapid diagnosis of IC and various other conditions in humans, cats, and/or other mammals.12-22-2011
20110313674INSULIN OPTIMIZATION SYSTEMS AND TESTING METHODS WITH ADJUSTED EXIT CRITERION ACCOUNTING FOR SYSTEM NOISE ASSOCIATED WITH BIOMARKERS - Embodiments of a testing method for optimizing a therapy to a diabetic patient comprise collecting at least one sampling set of biomarker data, computing a probability distribution function, a hazard function, a risk function, and a risk value for the sampling set of biomarker data wherein, wherein the probability distribution function is calculated to approximate the probability distribution of the biomarker data, the hazard function is a function which yields higher hazard values for biomarker readings in the sampling set indicative of higher risk of complications, the risk function is the product of the probability distribution function and the hazard function, and the risk value is calculated by the integral of the risk function, minimizing the risk value by adjusting the diabetic patient's therapy, and exiting the testing method when the risk value for at least one sampling set is minimized to an optimal risk level.12-22-2011
20110313673METHODS AND APPARATUS FOR DECENTRALIZED DIABETES MONITORING - Methods for decentralized monitoring of a progression of a diabetic state of a patient include contemporaneously obtaining an initial set of venous blood samples and an initial set of capillary blood samples after a standardized metabolic challenge from the patient in a centralized setting, wherein the diabetic state is diagnosed using the initial set of venous blood samples and a first test baseline is established by correlating the initial set of capillary blood samples with the initial set of venous blood samples, implementing a therapy, performing decentralized testing after reaching a target event, wherein a status test is obtained from a status set of capillary blood samples obtained from the patient after a subsequent standardized metabolic challenge, and comparing the status test with the first test baseline to determine an effectiveness of the therapy.12-22-2011
20110313672CELLULAR ANTIOXIDANT ACTIVITY (CAA) ASSAY - A cellular antioxidant activity (CAA) assay for quantifying the antioxidant activity of phytochemicals, food extracts, and dietary supplements has been developed. Dichlorofluorescin is a probe that is trapped within cells and is easily oxidized to fluorescent dichlorofluorescein (DCF). The method measures the ability of compounds to prevent the formation of DCF by 2,2′-azo-bis(2-amidinopropane) dihydrochloride (ABAP)-generated peroxyl radicals in human hepatocarcinoma HepG2 cells. The decrease in cellular fluorescence when compared to the control cells indicates the antioxidant capacity of the compounds. The antioxidant activities of selected phytochemicals and fruit extracts were evaluated using the CAA assay and the results were expressed in μ-mol quercetin equivalents/100 μ-mol phytochemical or μ-mol quercetin equivalents/100 g fresh fruit. Quercetin had the highest CAA value, followed by kaempferol, epigallocatechin gallate (EGCG), myricetin, and luteolin among the pure compounds tested. Among the selected fruits tested, blueberry had the highest CAA value, followed by cranberry>apple=red grape>green grape. The CAA assay is a more biologically relevant method than the popular chemistry antioxidant activity assays because it accounts for aspects of uptake, metabolism, and location of species within cells.12-22-2011
20130191032VERSION CONTROL FOR MEDICAL ANESTHESIA DEVICES - A testing system, a testing process, a medical device, e.g., an anesthesia device (G), and a computer program product are provided for testing installed program versions for acceptability. The anesthesia device (G) comprises a plurality of electronic components (K), which are operated and/or controlled with a program, which may have various versions. A release function (07-25-2013
20130191033Analyzing spectra - Systems and methods for analyzing spectra are described. In analyzing the spectra, peaks are identified, and complexes and sub-complexes are assigned to their respective peaks.07-25-2013
20130191034ENERGY EXPENDITURE - Aspects relate to calculating energy expenditure values from an apparatus configured to be worn on an appendage of a user. Steps counts may be quantified, such as by detecting arm swings peaks and bounce peaks in motion data. A search range of acceleration frequencies related to an expected activity may be established. Frequencies of acceleration data within a search range may be analyzed to identify one or more peaks, such as a bounce peak and an arm swing peak. Novel systems and methods may determine whether to utilize the arm swing data, bounce data, and/or other data or portions of data to quantify steps. The number of peaks (and types of peaks) may be used to choose a step frequency and step magnitude. At least a portion of the motion data may be classified into an activity category based upon the quantification of steps.07-25-2013
20110320131BIOLOGICAL INFORMATION PROCESSING APPARATUS, BIOLOGICAL INFORMATION DISPLAY APPARATUS, TELEMEDICAL SYSTEM, TELEMEDICAL METHOD, PROCESSING CONTROL PROGRAM, DISPLAY CONTROL PROGRAM, AND STORAGE MEDIUM - In order that a telemedical system which can take into account reliability of data from a patient is provided, a patient-side terminal in the telemedical system is connected with a server via a communications network, and includes a communication section which obtains first biological information indicating a physiological state of a user from a sensing apparatus which measures a physiological state of a user, an input section which accepts an input from a user so as to obtain second biological information, and a control section which (i) adds, to the first biological information, first distinguishing information indicating that the first biological information is information obtained by the communication section, and (ii) adds, to the second biological information, second distinguishing information indicating that the second biological information is information obtained by the input section, so that the first biological information and the second biological information are distinguished from each other. The communication section transmits the distinguishable first and second biological information to the server.12-29-2011
20120010821Nucleic Acid Abundance Ratio Measurement Device, Method, and Program Storage Medium, Determination Method and Nucleic Acid Abundance Ratio Measurement Kit - A nucleic acid abundance ratio measurement device includes a detection section that detects a detection signal over different temperature ranges of a melting curve for a nucleic acid mixture having one or more melting temperatures, and an abundance ratio computation section that computes a nucleic acid abundance ratio based on a ratio of characteristic amounts obtained from the detection signal detected by the detection section and based on detection amount data.01-12-2012
20120029832Apparatus and method for distribution of biological material - A new approach is proposed that contemplates systems and methods to support improved means for handling of biological materials, for example biological samples or products used in biological or biomedical research, diagnostics or therapy. In particular, the proposed approach provides improved means for handling patient samples and products used in regenerative medicine, such as biological or biochemical products or cell products. Improvements in for example, the ability to culture, process, distribute or preserve, i.e. increase the usable life of biological products, including cell products, in regenerative medicine would enable more widespread use of such products and uptake of regenerative medicine procedures.02-02-2012
20120029831FLUORESCENCE DETECTING DEVICE AND FLUORESCENCE DETECTING METHOD - A fluorescence detecting device receives fluorescence emitted by n kinds of measurement objects within wavelength bands FL02-02-2012
20120029830BLOOD GLUCOSE MEASUREMENT DEVICES AND METHODS OF USING THE SAME - Blood glucose measurement devices and methods of using the same. In at least one exemplary embodiment of a device of the present disclosure, the device comprises a main housing sized and shaped to receive a lancet assembly and a test strip holder, a circuit board positioned within the main housing, the circuit board capable of producing data indicative of a test strip fluid, and a processor operably coupled to the circuit board, the processor capable of receiving and processing the data from the circuit board and displaying a processed result on a screen.02-02-2012
20120029829Light Focusing Continuous Wave Photoacoustic Spectroscopy And Its Applications To Patient Monitoring - The present disclosure describes systems and methods that use spatial modulation to focus continuous wave light into a localized region of interest such as an individual blood vessel. In certain embodiments, intensity modulation techniques, such as linear frequency modulation, are used in conjunction with spatial modulation to achieve more precise measurements through otherwise scattering medium. The focused beam of continuous wave light is capable of penetrating several centimeters of tissue to deliver measurements and images associated with individual blood vessels and other discrete vascular components.02-02-2012
20130197811Method for Diagnosis of an Infectious Disease Stage and Determination of Treatment - The present invention relates to a means for determining if mammals within a group of mammals is affected by an infection that induces or could induce inflammation, if the mammal is likely to recover or not and if infected whether the mammal should be treated or let to recover untreated. By differentiating infected mammals in a group into different subsets representing differing stages of the progress of the disease the present invention teaches how to prognosticate with continuous data the outcome of a treatment/no treatment decision.08-01-2013
20130197812SYSTEMS AND METHODS FOR DETECTION OF CHROMOSOMAL GAINS AND LOSSES - A modified principal component analysis technique is described herein for analysis of relatively small data sets for the detection of chromosomal aneuploidies and/or microdeletions. Unlike analysis techniques for microarray studies, the present technique uses a modified principal component analysis that does not involve performing a covariance analysis. The methods, systems, and apparatus described herein allow for significant reduction of data noise in tests for the detection of chromosomal aneuploidies and/or microdeletions, leading to fewer inconclusive results.08-01-2013
20120296570DEVICE AND METHOD FOR MULTIPARAMETER MEASUREMENTS OF MICROPARTICLES IN A FLUID - The invention relates to a method of classifying and flow measuring the refringence of at least two populations of particles present in a fluid. The method uses a light source that has small coherence time, with a coherence length Lc<100 μm, that is used under extinction conditions at a center wavelength selected as a function of a range of volumes and of a range of refractive indices expected for the particles under consideration. The method uses a device that, together with the light source, forms a converging illuminating beam of aperture angle that is selected as a function of the range of volumes and the range of refractive indices expected for the particles under consideration at the selected center wavelength.11-22-2012
20120041685SYSTEM AND METHOD FOR ESTIMATING RADIATION DOSE AND DISTRIBUTION USING MEDIUM-DEPENDENT-CORRECTION BASED ALGORITHMS (MDC) - Systems and methods for accurately calculating radiation doses in biological tissues exposed to a radiation source are provided. In the systems and methods first, a radiation dose is computed to geometry of water equivalent medium of the biological tissues, expressed in computed tomography (CT) volumetric images. A Medium-Dependent-Correction factor that is a function of an effective bone depth matrix and the incident x-ray beam is obtained and tabulated. Using patient material and density data derived from CT images, the effective bone thickness can be calculated from a specific x-ray source. Finally, a Medium-Dependent-Correction factor that is a function of an effective bone depth matrix is used to accurately determine the radiation dose distributions to biological tissues.02-16-2012
20120046873HAIRSCAN FOR GROWTH ANALYSIS - Effectiveness of a therapeutic regimen applied to hair follicles is determined by establishing a baseline cross-sectional dimension of a first cross-sectional portion of a hair shaft that is acquired from a target area of a patient. A post-therapeutic cross-sectional dimension of a second cross-sectional portion of a hair shaft that is acquired from the target area of a patient subsequent in time to the acquisition of the first cross-sectional portion of a hair shaft and to an application of a therapeutic agent to a hair follicle that generated the second cross-sectional hair shaft portion, is also determined. Thus, a difference between the baseline and post-therapeutic cross-sectional dimensions is determined and used to automatically revise a therapeutic regimen frequency, duration, or duty cycle for an application of the therapeutic agent applied to the hair follicle that generated the post-therapeutic hair shaft portion.02-23-2012
20120046872Method and Arrangement for the Control of Measuring Systems, Corresponding Computer Program and Corresponding Computer-Readable Storage Medium - Disclosed herein is a method and an arrangement for the control of measuring systems such as a mass spectrometer or nuclear magnetic resonance (NMR) instrument, the control being based on an online data analysis of the current measurements. Depending on the measurement experiment, the combined result of the data analysis can have either a direct influence on the next measurement or result in a dynamically organized sequence of measurements. The measuring systems may be controlled by establishing a database that comprises information on the objects to be measured, the measurement data which can be detected during the measurement experiments using the measuring systems, and information regarding the relationships between or among items of the measurement data.02-23-2012
20130204535VISUALIZING PREDICTED AFFECTIVE STATES OVER TIME - Described herein are various technologies pertaining to estimating affective states of a user by way of monitoring data streams output by sensors and user activity on a computing device. Models of valence, arousal, and engagement can be learned during a training phase, and such models can be employed to compute values that are indicative of valence, arousal, and engagement of a user in near-real time. A visualization that represents estimated affective states of a user over time is generated to facilitate user reflection.08-08-2013
20130204536METHODS OF KINOME ANALYSIS - Method for analyzing phosphorylation data of a plurality of peptides are provided, the method comprising obtaining one or more datasets, each dataset comprising a phosphorylation signal intensity for each replicate of the plurality of peptides for a sample; transforming the phosphorylation signal intensity of each replicate of the plurality of peptides using a variance stabilizing transformation to provide a variance stabilized signal intensity for each replicate of the plurality of peptides; and identifying one or more peptides of the plurality of peptides that is/are consistently phosphorylated or consistently unphosphorylated.08-08-2013
20120072123Methods of Predicting The Probability of Modulation of Transcript Levels By RNAI Compounds - The present invention provides a method for determining the probability that an RNAi compound modulates the expression level of a gene using a linear regression model. The present invention also provides a method for determining the probabilities that an RNAi compound modulates the expression levels of each gene in a set of genes of interest using the linear regression model. The present invention provides a method for determining the seed-sequence-dependent signature size of an RNAi compound using the linear regression model. The invention provides a method for identifying genes having seed-sequence-dependent silencing effect by an siRNA using the linear regression model. The invention further provides a method for selecting from a plurality of siRNAs one or more siRNAs with higher silencing efficacy, specificity and diversity in silencing a target gene in an organism. The invention also provides a method for determining the coefficients of the above linear regression model.03-22-2012
20120072122Forensic Integrated Search Technology - A system and method to search spectral databases and to identify unknown materials. A library comprising sublibraries is provided, each sublibrary containing a plurality of reference data sets corresponding to known materials. Test data sets are provided, characteristic of an unknown material. Each test data set is generated by one or more spectroscopic data generating instruments. Each sublibrary is searched and a corresponding set of scores is produced, indicating a likelihood of a match. Relative probability values are calculated for each searched sublibrary. All relative probability values are fused producing a set of final probability values, used to determine whether the unknown material is represented through a known material in the library. A highest final probability value is selected compared to a minimum confidence value. If the probability value is greater than or equal to the minimum confidence value, the known material is reported.03-22-2012
20120078524System and method for diagnosis tissue samples using fluorescence and raman techniques - A system and method for determining a diagnosis of a test biological sample. A system comprising a first illumination source to illuminate a sample, a first detector for generating a fluorescence data set of said sample, a means for determining a region of interest, a second illumination source to illuminate said region of interest, a second detector to generate a Raman data set of said region of interest, and a means for determining a diagnosis of said sample. A method comprising illuminating a sample, generating a fluorescence data set of said sample, and assessing the fluorescence data set to identify a region of interest, illuminating a region of interest, and generating Raman data set. This Raman data set may be assessed to determine a diagnosis of the sample. A diagnosis may include a metabolic state, a clinical outcome, a disease progression, a disease state, and combinations thereof.03-29-2012
20120095695METHODS AND SYSTEMS FOR HIGH CONFIDENCE UTILIZATION OF DATASETS - Methods and systems for high-confidence utilization of datasets are disclosed. In one embodiment, the method includes selecting a metric for determining substantially optimal combination of true positives and false positives in a data set, applying an optimization technique, and obtaining, from the results of the optimization technique, a value for at least one optimization parameter, the value for at least one optimization parameter resulting in substantially optimal combination of true positives and false positives. A number of true positives and a number of false positives are a function of the one or more optimization parameters.04-19-2012
20120095694METHODS AND SYSTEMS FOR HIGH CONFIDENCE UTILIZATION OF DATASETS - Methods and systems for high-confidence utilization of datasets are disclosed. In one embodiment, the method includes selecting a metric for determining substantially optimal combination of true positives and false positives in a data set, applying an optimization technique, and obtaining, from the results of the optimization technique, a value for at least one optimization parameter, the value for at least one optimization parameter resulting in substantially optimal combination of true positives and false positives. A number of true positives and a number of false positives are a function of the one or more optimization parameters.04-19-2012
20120095693METHOD AND SYSTEMS FOR PROCESSING POLYMERIC SEQUENCE DATA AND RELATED INFORMATION - Methods and systems for organizing, representing and processing polymeric sequence information, including biopolymeric sequence information such as DNA sequence information and related information are disclosed herein. Polymeric sequence and associated information may be represented using a plurality of data units, each of which includes one or more headers and a payload containing a representation of a segment of the polymeric sequence. Each header may include or be linked to a portion of the associated information.04-19-2012
20120095692METHOD FOR COMBINING SUB-THERAPEUTIC DOSES - A method is disclosed for selecting ingredient subsets for evaluation. The method receives a selection of at least one primary clinical effect and selects a plurality of ingredients that have the at least one primary clinical effect. In addition, the method scores for each ingredient a strength of the at least one primary clinical effect and each secondary clinical effect for an average therapeutic dose normalized to body mass for each of a group of subjects. The method further selects for evaluation each subset of the plurality of ingredients satisfying the equation04-19-2012
20120095691HANDHELD DIABETES MANAGEMENT DEVICE HAVING TESTING IN PAIRS BLOOD GLUCOSE TEST - A method for conducting a Testing In Pairs (TIPs) blood glucose (bG) test using a handheld diabetes management device carried by a user. A processing subsystem of the device implements a software module for managing the TIPs test. The software module generates a plurality of predetermined acceptance time windows corresponding to different user defined events. The processing subsystem can identify specific ones of a plurality of bG test values read by the device that are obtained during the predetermined bG acceptance time windows, and which are identified as being related pairs of accepted bG test values that correspond to specific ones of the user defined events. The related pairs of accepted bG test values can then be stored in a database.04-19-2012
20130211729DATA ANALYSIS OF DNA SEQUENCES - Systems and methods for data analysis are provided. In one embodiment, a method for analysis is provided, including electronically receiving sequence data; electronically receiving one or more reference data sequences related to at least an expression vector; associating the sequence data with at least one of the reference data sequences to identify a transgene flanking sequence; searching a genome for one or more insertion sites of the transgene flanking sequence; and annotating the genome and the one or more insertion sites within the genome when one or more insertion sites are found in said searching step.08-15-2013
20130211730METHOD AND DEVICE FOR THE MEASUREMENT AND THE ELIMINATION OF SYSTEM CHANGES IN A DEVICE FOR THE TREATMENT OF BLOOD - The present invention relates to a method and a device for the measurement of pressure signals in a blood treatment system, whereby system changes can be identified and can be differentiated additionally reliably between system changes in blood flow direction and in transmembrane direction in order to enable a targeted action.08-15-2013