Entries |
Document | Title | Date |
20080201081 | Analytical Method and Apparatus - A method for analysing function of a biosystem ( | 08-21-2008 |
20080201082 | Blood image analyzer - A blood image analyzer is disclosed that comprising: an image capturing unit for capturing a blood image of a sample; an analyzing part for analyzing the sample based on the blood image; an identification information reader for reading, from the sample, identification information assigned to the sample; a transportation part for transporting the sample to the identification information reader and the image capturing unit; a first detector for detecting the sample at a first detection position on a pathway of the sample transported by the transportation part; a display; and a controller for controlling the display, so as to display, based on a detection result by the first detector, a screen including a first identification information display region, wherein the first identification information display region displays identification information of the sample being at the first detection position. | 08-21-2008 |
20080208479 | Devices and Methods for Calculating and Communicating Differences in Measured Data - The current invention provides a measurement device having a data processing means that collects measurement data points, stores the collected measured data points and calculates differences and changes in said measurement data points. The device communicates these changes in measured data points to the user. The device does not communicate the measured value to a user. Also provided is a method for monitoring changes in measured data. | 08-28-2008 |
20080208480 | INFORMATION MANAGEMENT SYSTEM AND INFORMATION MANAGEMENT SERVER - For the purpose of effectively supervising a user of the health indexes that cannot always be measured, such as the weight and blood pressure, warning and information are provided based on a prediction of the health indexes. In an information management system, in which a first parameter that is not always measured is predicted from a second always measurable parameter. | 08-28-2008 |
20080208481 | AUTOMATIC ANALYZER - The automatic analyzer is provided with a function of, based on selection of the output result targeted by a user from among all printed results output by the automatic analyzer, proceeding to a start page of the targeted output result so that the targeted output result is displayed, on a screen for displaying a list including a title of printing, the date of printing, a range of pages, and a user's check indicating whether or not the user has checked the result. The automatic analyzer is also provided with a function of enabling a user to add a check indicating whether or not the verification/confirmation of data has been performed, the check date, a checker, a comment, and the like, to the measurement result targeted by the user, and the like, on a screen displaying the result. | 08-28-2008 |
20080215247 | Machine and Procedure For Extracorporeal Treatment of Blood - A machine ( | 09-04-2008 |
20080215248 | Method and Device for the Measurement and Identification of Biofilms and Other Deposits Using Vibration - The present invention concerns a method and device to monitor the formation and removal of biofilms and other deposits in ducts, reservoirs and equipments, using vibration. The afore mentioned device is composed by an element that generates vibration ( | 09-04-2008 |
20080215249 | Crystallization and structure determination of beta secretase and/or beta secretase-like proteins - The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of human BACE activity. | 09-04-2008 |
20080221802 | Method of Proteome Analysis for Phosphorylated Protein - A method for detecting plural types of phosphorylated proteins in a sample, wherein a database consisting of data regarding plural types of proteins in the sample is used; and a method for purifying phosphorylated proteins using an immobilized metal carrier or a titania carrier, wherein a solution containing acetonitrile in a range of 40% (v/v) or greater but 60% (v/v) or less is used. | 09-11-2008 |
20080221803 | Methods of predicting treatment outcome in chronic periodontitis patients - The invention is a new method for predicting when subjects having chronic periodontitis will fail or succeed conventional standard therapy. The method uses measures of the plaque cadaverine fraction with additional measurements including age, fraction of gingival margins that bleed on probing (BOP), and clinical attachment level (CAL in mm) to calculate discriminant function equations for calculating individual score sets. When CF is above 0.45 in periodontitis patients, it is predicted that most available therapies with which the periodontitis patient can be treated will fail, including a conventional standard treatment or an aggressive combined antibiotic/oral hygiene therapy. | 09-11-2008 |
20080221804 | System of Processing Patient Medical Data - A system is described for assisting in the interpretation of medical images by making available information derived from other tests such as in vitro testing. In a preferred embodiment, an in vitro diagnostic testing device is integrated with a scanner such as a Positron Emission Tomography (PET) device so that both types of data can be simultaneously acquired and presented to the diagnosing physician. | 09-11-2008 |
20080221805 | MULTI-CHANNEL LOCK-IN AMPLIFIER SYSTEM AND METHOD - A multi-channel lock-in amplifier system for use in cell analysis is disclosed. The system may include a cartridge having one or more flow cells with each flow cell containing a cell for analysis. An oscillating electric field may be applied across each flow cell at one or more excitation frequencies in order to detect the responses of the cell either in electrical impedance at frequencies that provide a non-linear response. | 09-11-2008 |
20080228404 | Systems and methods for high-speed image scanning - Systems and methods for high-speed image scanning are disclosed herein One aspect of the invention is directed to a method for high speed image scanning. The method for high speed image scanning includes adjusting an object using a positioning element; directing a portion of an image of the object toward a sensor by positioning a first mirror relative to the object, and by positioning a second mirror relative to the object and the first mirror; controlling the positioning element, the position of the first mirror and the position of the second mirror using a processor; and detecting the portion of the image of the object using the sensor positioned relative to the first mirror and the second mirror. In accord with this method, the first mirror directs the portion of the image of the object in a first direction and the second mirror directs the portion of the image of the object in a second direction. | 09-18-2008 |
20080228405 | Search Space Coverage With Dynamic Gene Distribution - A method and apparatus for selecting measurements from a plurality of measurements is disclosed. The method includes the steps of initializing a measurement status to a first value for each of the measurements, determining selectability of one of the plurality of measurements based on a corresponding status value, and updating the status to a second value after selecting the measurement. In one aspect of the invention, the step of determining selectability further comprises the step of selecting one of the plurality of measurements, and retaining the selected measurement when the value of the corresponding status is the first value. | 09-18-2008 |
20080228406 | SYSTEM AND METHOD FOR FUNGAL IDENTIFICATION - A service for the identification of at least one fungal organism suspected of being present in a test sample is described and comprises a processing capacity for the sample, a sequencing capacity for generating sequence information, a sequence information processing capacity, an assessment capacity, and a reporting capacity for reporting results to an end user. Also described are methods and systems of determining the presence and identity of at least one fungus in a sample. | 09-18-2008 |
20080228407 | Method for Protein Structure Alignment Using Cellular Automata - The detection of protein sequence alignments firstly generates protein blocks having n successive C-alpha atoms from two protein sequences. A matrix of the distance of protein atoms from said C-alpha atoms for each block is then determined. A difference matrix is determined from respective distance matrices representing the differences between the protein blocks of the two protein structures. A Cellular Automaton (CA) model is generated in an initial configuration based upon the difference matrix, and evolved through at least one generation using predetermined rules. The rules determine which CA cells remain live and which are set to be dead. | 09-18-2008 |
20080228408 | Method for Determining the State of an Ensemble of Cells and System for the Implementation of the Method - The invention concerns a method for determining the condition of at least one culture of prokaryotic or eukaryotic cells defined in greater detail herein, including in particular one or more steps for simultaneously analyzing the condition of a large number of biological markers of interest. The inventive method, enables, in some cases, the cellular response to a plurality of modifications of environmental conditions to be simultaneously determined, including, for example, the simultaneous determination of the cellular response to various compounds to be tested. | 09-18-2008 |
20080228409 | SYSTEMS AND METHODS FOR PROBE DESIGN BASED ON EXPERIMENTAL PARAMETERS - Systems and methods for using the same to select or design probes specific for a target nucleic acid based on experimental parameters are provided. Also provided are computer program products for executing the subject methods. | 09-18-2008 |
20080234941 | Method of Designing Sirnas for Gene Silencing - The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity. | 09-25-2008 |
20080234942 | Analyzing Body Tissue - The invention describes a method for analysing a body tissue sample, the method comprising irradiating the tissue sample ( | 09-25-2008 |
20080234943 | COMPUTER PROGRAM FOR DIABETES MANAGEMENT - A diabetes management system or process is provided herein that may be used to analyze and recognize patterns for a large amount of blood glucose concentration measurements and other physiological parameters related to the glycemia of a patient. In particular, a method of monitoring glycemia in a patient may include storing a patient's data on a suitable device, such as, for example, a glucose meter. The patient's data may include blood glucose concentration measurements. The diabetes management system or process may be installed on, but is not limited to, a personal computer, an insulin pen, an insulin pump, or a glucose meter. The diabetes management system or process may identify a plurality of pattern types from the data including a testing/dosing pattern, a hypoglycemic pattern, a hyperglycemic pattern, a variability pattern, and a comparative pattern. After identifying a particular pattern with the data management system or process, a warning message may be displayed on a screen of a personal computer or a glucose meter. Other messages can also be provided to ensure compliance of any prescribed diabetes regiments or to guide the patient in managing the patient's diabetes. | 09-25-2008 |
20080234944 | Method and Apparatus for Subset Selection with Preference Maximization - A method and apparatus for determining a subset of measurements from a plurality of measurements in a genetic algorithm is disclosed. The method comprising the steps of determining a fitness measure for each sub-set of the measurements, wherein each measurement has an associated fitness measure and selecting the subset of measurements having the lowest fitness measure ( | 09-25-2008 |
20080234945 | Means and Methods for Analyzing a Sample by Means of Chromatography-Mass Spectrometry - The present invention relates to a method for analyzing at least one test sample, wherein said test sample comprises at least one compound, said method comprising the steps of: a) providing at least one test sample comprising at least one compound; b) determining said at least one compound in said test sample whereby raw results are generated; and c) analyzing the raw results obtained in step b), wherein the analysis of said at least one test sample is accompanied by an analysis of at least one reference sample; and wherein the test sample and the reference sample are analyzed in an identical sequence in each step of the method. Moreover, the present invention further encompasses a system for carrying out said method comprising operatively linked to each other: (a) means for determining a compound; (b) means for monitoring process parameters, (c) means for analyzing raw results obtained from the means according to (a), wherein said means for analyzing raw results comprise: (i) a first database comprising raw results received from the means according to (a); (ii) a second database comprising monitored process parameters received from the means according to (b); (iii) a third database comprising rules for evaluating the raw results; and (iv) a fourth database comprising allocated results of identified compounds; wherein at least the second, third and fourth database are operatively linked to the first database. | 09-25-2008 |
20080234946 | PREDICTIVE RADIOSENSITIVITY NETWORK MODEL - This invention is a model that simulates the complexity of biological signaling in a cell in response to radiation therapy. Using gene expression profiles and radiation survival assays in an algorithm, a systems model was generated of the radiosensitivity network. The network consists of ten highly interconnected genetic hubs with significant signal redundancy. The model was validated with in vitro tests perturbing network components, correctly predicting radiation sensitivity 2/3 times. The model's clinical relevance was shown by linking clinical radiosensitivity targets to the model network. Clinical applications were confirmed by testing model predictions against clinical response to preoperative radiochemotherapy in patients with rectal or esophageal cancer. | 09-25-2008 |
20080234947 | SCIENTIST DOMAIN-CENTRIC USER INTERFACE AND ENABLING "SOFT" TRANSLATION - The scientist domain-centric user interface system may prompt the user to supply scientist-centric information expressed utilizing terminology of a scientific domain, such as biology or analytical chemistry. A translation system then generates control parameters to control the search algorithm, thus relieving the user from having to learn how select and configure the algorithm control parameters directly. | 09-25-2008 |
20080243393 | Biometric information measuring apparatus and biometric information measuring system - A biometric information measuring apparatus has a storage device for storing data concerning a biometric signal or biometric information derived from the biometric signal in association with position information indicating the current location of a sensor unit of the apparatus. Since the biometric information measuring apparatus provides the position information acquired when the data on the biometric signal or the biometric information was obtained, one can know the location and behavior of a subject at the time of measurement and exactly analyze the biometric information on the subject. | 10-02-2008 |
20080243394 | SYSTEM, METHOD AND COMPUTER PROGRAM PRODUCT FOR MANIPULATING THERANOSTIC ASSAYS - A theranostics technique for describing signaling pathway activity within a cellular or tissue sample may include analyzing a cellular sample to obtain sample quantitative values for a series of target protein modification levels reflected in a set of a plurality of protein biomarkers in the sample. The sample quantitative values may be compared to reference quantitative values for the same series of protein modification levels. The reference quantitative values may be statistically processed from a plurality of comparable samples. The sample quantitative values may be displayed in relation to the reference quantitative values in a way that may suggest a specific course of treatment. | 10-02-2008 |
20080243395 | IMAGE DIAGNOSIS SUPPORTING APPARATUS AND SYSTEM - In a disease case DB, disease case images are classified by disorder and registered. In a feature quantity DB, a feature quantity (second feature quantity) of each disease case image classified by disorder is registered. A server compares a feature quantity (first feature quantity) of a lesion site included in a diagnosis target image, with the second feature quantity on a disorder-by-disorder basis, retrieves representative disease case images based on a comparison result from the disease case DB on a disorder-by-disorder basis, and provides a user with retrieved representative disease case images. Therefore, the user can obtain disease case images useful for determining a disorder or statistical information and the like regarding the disorder during image diagnosis based on the diagnosis target image. | 10-02-2008 |
20080255763 | SYSTEM AND A METHOD FOR OBSERVING AND PREDICTING A PHYSIOLOGICAL STATE OF AN ANIMAL - A system for observing and predicting a physiological state of an animal has been provided. The system includes a computer including a processor and being operatively connected to a database, at least one sample providing device for repetitively providing at least one sample of a body fluid of the animal, an analysis apparatus for analyzing the at least one sample, so as to obtain at least one sample value of at least one parameter of the body fluid, a data interface for repetitively entering the sample value of the at least one parameter in the database, where the database is adapted to store multiple database entries representing the sample value of the at least one parameter at various points in time, and where the processor is programmed to: perform at least one mathematical analysis of the at least one sample value, and selecting, on the basis of the at least one mathematical analysis, the point in time for providing a subsequent sample and performing a subsequent analysis of the subsequent sample for at least one of the parameters. | 10-16-2008 |
20080255764 | Methods for the Diagnosis of Colorectal Cancer and Ovarian Cancer by the Measurement of Vitamin E-Related Metabolites - The present invention relates to the diagnosis of colorectal and ovarian cancers (CRC and OC, respectively). The present invention describes the relationship between endogenous small molecules and CRC or OC. Specifically, the present invention relates to the diagnosis of CRC and OC through the measurement of vitamin E isoforms and related metabolites. The present invention also relates to diagnostic markers identified in said method. The present invention relates to the underlying case and pre-symptomatic phases of CRC, the diagnosis of various stages and severity of CRC, the early detection of CRC, monitoring and diagnosing the effect of therapy on CRC and OC health states. | 10-16-2008 |
20080255765 | MONITORING CYCLOSPORINE IN SALIVA - Saliva offers an alternative specimen for the therapeutic monitoring of cyclosporine (CsA) in children and patients with difficult venous access. For a highly protein-bound drug such as CsA, saliva provides a practical approach for measuring the unbound concentration. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is ideally suited for the measurement of drugs in saliva. A solid-phase extraction technique, analytic liquid chromatography over an Aqua Perfect column, maintained at 65° C., and electrospray tandem mass spectrometry were used to quantify CsA in saliva. The method used cyclosporine C (CsC) as the internal standard. Mobile phase comprised of a 97:3 voL mixture of methanol and 30 mmol/L ammonium acetate at a flow rate of 0.5 mL/min. Chromatograms using mass transitions of m/z 1219.9→m/z 1202.9 for CsA and m/z 1235.9→m/z 1218.9 for CsC were obtained. The calibration curve was linear from 1 to 300 μg/L with correlation coefficient values ranging from 0.9732 to 0.9968). The lower limit of quantification was 1 μg/L and limit of detection was 0.6 μg/L with an average extraction recovery of 84.7±2.6% for CsA and 93.7±4.4% for CsC from the saliva matrix. The accuracy of the method ranged from 92% to 104.7%, and the intra- and interim coefficients of variation were 6.9-12.2% and 8.3-12.1%, respectively. The correlation coefficient value between the CsA concentration measurements in 15 paired blood-saliva samples from kidney transplant recipients was 0.695 (P=0.006). The noninvasive and simple method of saliva collection coupled with the LC-MS/MS quantification technique for CsA analysis would generate novel data that could benefit patients undergoing CsA therapy. | 10-16-2008 |
20080255766 | Methods and kits for the diagnosis of sickle cell - Provided are methods for the detection and diagnosis of sickle cell. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of sickle cell. At least two new biomarkers for sickle cell are thus disclosed, Eotaxin and Monocyte Chemotactic Protein-1. Altogether the concentrations of eleven analytes provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from sickle cell. Other important biomarkers for sickle cell are described, including but not limited to IL-12p40, SHBG, MMP-9, Adiponectin, Haptoglobin, FGF basic, IgM, Growth Hormone, Factor VII. Kits containing reagents to assist in the analysis of fluid samples are also described. | 10-16-2008 |
20080262739 | Submersible Portable In-situ Automated Water Quality Biomonitoring Apparatus and Method - A submersible biomonitoring system for monitoring water quality in situ includes a submersible chamber constructed of a di-electric material and sized to allow suitable signals from one or more aquatic organisms to be received by eliminating cross-talk between cells while allowing ambient conditions to be maintained inside the chamber. The aquatic organism exhibits ventilatory behavior and body movement sensitive to water quality which manifest as electrical signals picked up by electrodes and communicated to a pre-amplifier that conditions the signals for communication to a land-based amplifier and/or controller that is used to interpret the signals to determine when the water to which the organism is exposed has caused physiological stress to the organism. | 10-23-2008 |
20080262740 | PERMITTIVITY-BASED MATERIAL SENSOR - A system for sensing a presence and/or a concentration of a target substance in a fluid has a sensor and a processor coupled to the sensor. The sensor has a test probe having at least first and second test electrodes, wherein at least the first test electrode is functionalized to create a permittivity change in the area between the first and second test electrodes in the presence of the target substance. The sensor also has a reference probe having at least first and second reference electrodes. The processor is configured to determine at least one permittivity-based metric for the test probe; determine the at least one permittivity-based metric for the reference probe; and determine the presence and/or the concentration of the target substance based on the at least one permittivity-based metric for the test probe and the at least one permittivity-based metric for the reference probe. Related methods are disclosed. | 10-23-2008 |
20080262741 | METHOD AND APPARATUS FOR SCREENING CHEMICAL COMPOUNDS - Methods and apparatus for screening large numbers of chemical compounds and performing a wide variety of fluorescent assays, including live cell assays. The methods utilize a laser linescan confocal microscope with high speed, high resolution and multi-wavelength capabilities and real time data-processing. Imaging may be done at video-rates and with use of ultraviolet illumination. | 10-23-2008 |
20080262742 | COMPUTATIONAL METHOD AND APPARATUS FOR PREDICTING POLYPEPTIDE AGGREGATION OR SOLUBILITY - A prediction method for predicting the effect of an amino acid modification on the rate of aggregation (solubility) of a reference polypeptide comprising: calculating the difference in hydrophobicity (ΔHydr) between the reference polypeptide and a modified polypeptide, calculating the difference in β-sheet propensity (ΔΔG | 10-23-2008 |
20080262743 | Methods for remote characterization of an odor - Provided are compositions and systems useful in remote monitoring of chemical hazards, air quality, and medical conditions, for example, robotic systems to search for and detect explosives, mines, and hazardous chemicals. In addition, the methods, systems and compositions of the invention provide the ability to mine data from a database containing a plurality of chemical fingerprints. | 10-23-2008 |
20080262744 | Systems and Methods for Tissue Engineering Tubular Biological Structures - The present invention relates to systems and methods for tissue engineering. In particular, the invention is directed toward systems and methods for conditioning tubular biological structures. For example, an aspect of the present invention comprises systems and methods for uncoupling local mechanical parameters (e.g., circumferential stress, shear stress, and axial stress) from global mechanical parameters (e.g. lumen pressure, flow rate of perfusate, and longitudinal stretch of the construct) to control of local mechanical parameters for conditioning a tubular biological construct. | 10-23-2008 |
20080262745 | Method for Determining Insulin Sensitivity and Glucose Absorption - The present invention encompasses a model-based method for determining insulin sensitivity and glucose absorption from oral glucose tolerance tests or mixed meals. The present invention has several advantages over current methods. The technique requires about four to six blood samples taken over about two to three hours following glucose ingestion and is therefore applicable to large-scale clinical trials. The analysis involves a reduced version of the classical minimal model, a method for describing glucose absorption using only two parameters, and an integral approach enabling the parameters to be obtained using simple algebra. The present method robustly identifies differences in insulin sensitivity in different patient types as well as improvements in insulin sensitivity arising from pharmaceutic therapy. In addition, insulin sensitivity measurements obtained with the present method are highly correlated with results from hyperinsulinemic clamps (r | 10-23-2008 |
20080262746 | METHOD AND DEVICE FOR PREDICTING PHYSIOLOGICAL VALUES - The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject. | 10-23-2008 |
20080270036 | SYSTEMS AND METHODS FACILITATING AUXILIARY ANALYSIS OF DATA FROM IMPLANTED MEDICAL DEVICES - Systems and methods facilitating auxiliary analysis of data collected by an implanted medical device employ a software application user interface, through which an analysis service may be invoked for a selected group of data sets collected from an implanted device; the group of data sets includes data sets that describe episodes detected and classified by an analysis performed by the device, and/or data sets that describe events indicative of a device integrity issue. The user interface informs, or notifies a user of the system if any of the results warrant further review of the corresponding data sets, and may display an organized report of results from the automated analysis. The report may be organized such that those results, which warrant further review, are displayed in a more prominent fashion than other results. | 10-30-2008 |
20080270037 | System and method for measuring and displaying health information - A system and method are provided for measuring and displaying health information. The system includes a measurement platform for performing one or more health information measurements, a terminal device for displaying the measurement results, and a portable storage device for storing the measurement information and user data. Push-pull output logic is used to provide for an efficient supply of power and to eliminate the consumption of power by the terminal device at the time of a signal input. | 10-30-2008 |
20080270038 | SYSTEM, APPARATUS AND METHOD FOR DETERMINING COMPATIBILITY BETWEEN MEMBERS OF A SOCIAL NETWORK - A system, apparatus, and method are provided to assist users to access and process information about a group of friends who are members of a third party social network in order to determine compatibility between the user and each friend or determine the most-compatible friends within that social network. In some embodiments, the system and method may obtain login or other authentication data regarding a user to access the user information on the third party social network, such as a list of friends (e.g., a buddy list) specified within the third party social network. After accessing the list of friends, information regarding each friend's preferences, interests, likes, dislikes, etc. may also be obtained from the third party social network. Subsequently, a compatibility measure between the user and each friend in the list is determined based on the obtained information regarding the friend and the user. The resulting compatibility measures may be filtered, sorted, ranked, or otherwise processed or acted upon prior to, or after presentation to the user. | 10-30-2008 |
20080270039 | METHOD AND DEVICE FOR PREDICTING PHYSIOLOGICAL VALUES - The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject. | 10-30-2008 |
20080270040 | Automated generation of multi-dimensional structure activity and structure property relationships - The present invention relates to automated generation of multi-dimensional structure activity and structure property relationships. | 10-30-2008 |
20080275651 | METHODS FOR INFERRING THE PRESENCE OF A PROTEIN IN A SAMPLE - A method of inferring presence of at least one protein in a sample includes entering a peptide training data set into a statistical inference model. The method further includes training the statistical inference model with the peptide training data set. The method further includes determining predicted detectability of at least one peptide present in the sample with the trained statistical inference model. The method further includes inferring the presence of the at least one protein in the sample based upon the determined predicted detectability. Methods for quantifying proteins present in a sample are also disclosed. | 11-06-2008 |
20080281526 | Methods For Molecular Toxicology Modeling - The present invention is based on methods of predicting toxicity of test agents and methods of generating toxicity prediction models using algorithms for analyzing quantitative gene expression information. The invention also includes computer systems comprising the toxicity prediction models, as well as methods of using the computer systems by remote users for determining the toxicity of test agents. | 11-13-2008 |
20080281527 | Microarray analytical data stitching system and method - A technique is provided for analyzing image data for biological microarrays. Images are made of multiple swaths in multiple passes of an imaging system. Sites encoded by the image data are assigned a value and these values are indexed by site location. An overlapping region of the swaths may be identified by analysis of the indexed site values. The site values for all image sites are then stitched and the data is integrated and stored for later analysis. | 11-13-2008 |
20080281528 | System and Method for Environmental Sampling and Diagnostic Evaluation - An environmental sampling system and method that collects biological contaminates in a removable cassette device via a sample capture media, such as a filter. The cassette device which is designed to specifically cause mixing of the air stream in a manner to get even distribution of the airborne particulates on the filter media has affixed thereto a data storage unit for storing other environmental parameters sensed and measured by the system in addition to the IAQ questionnaire information inputted by the investigator. After the sample period is complete, the system can be re-deployed in the field or environment by simply replacing the removable cassette device having the data storage unit. The collected biological contaminates in a removable cassette device and stored data in the affixed data storage unit are sent to a laboratory for analysis. The environmental sampling system may be operated independently of the removable cassette device to obtain and data log physical environmental data such as temperature, relative humidity, wind velocities, pressure differentials, and particulate counts. | 11-13-2008 |
20080281529 | GENOMIC DATA PROCESSING UTILIZING CORRELATION ANALYSIS OF NUCLEOTIDE LOCI OF MULTIPLE DATA SETS - Processing of genomic data is facilitated utilizing correlation analysis of mapped data sets, each data set including genomic data mapped and ordered relative to a genomic coordinate system. Correlation analysis identifies at a nucleotide level nucleotide positions wherein at least one nucleotide locus of each data set correlate. The analysis includes for each data set, selecting a nucleotide locus thereof closest to one end of the coordinate system, comparing the selected nucleotide loci for correlation, and if so, outputting results of the comparing, and updating the selected nucleotide loci by identifying the data set having a next nucleotide locus closest to the one end of the coordinate system, and inserting that next locus into the group of selected loci, and repeating the comparing for the newly selected loci. The process is repeated until nucleotide loci of the mapped data sets are compared and results of the comparison are output. | 11-13-2008 |
20080288174 | Method for Identifying the Function of a Gene - Described is a method for determining the function of a gene. This method involves determining the amount of transcript for each of a set of candidate genes in samples taken from different phenotypic and/or genotypic states of an organism and determining the amount of each of a plurality of metabolites in different samples taken from the same states as those mentioned above. Subsequently, the data obtained is analyzed by suitable mathematical methods in order to identify a transcript and metabolites which correlate in the different states, thereby identifying a transcript corresponding to a gene which influences the amount of metabolites in the organism. Furthermore described is a method for identifying a gene which is capable of modifying the amount of a metabolite in an organism and to a method for identifying a metabolite which is capable of modifying the amount of a transcript in an organism. Likewise, uses of the genes and metabolites identified in the aforementioned methods are described. | 11-20-2008 |
20080288175 | INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND PROGRAM - An information processing apparatus is disclosed which processes information about a network including a plurality of nodes representative of cellular molecules, the information processing apparatus including a detection section configured to detect from the network a node group corresponding to a switch pattern including at least two nodes potentially constituting a candidate of a molecular switch. | 11-20-2008 |
20080288176 | Development of Prodrugs Possessing a Nitric Oxide Donor Diazen-1-Ium-1,2-Diolate Noiety Using in Vitro/in Silico Predictions - The present invention provides a method of using a physiologically-based pharmacokinetic model to select a prodrug molecule (NO—X) comprising a therapeutic agent X (e.g. nonsteroidal anti-inflammatory drug, (NSAID)) and an appropriate nitric oxide donor NO. The NSAID can be a non-selective or selective cyclooxygenase inhibitor or other biocompatible compound comprising a carboxyl group. The pharmacokinetic model uses in vitro and/or in silico data to estimate an optimal set of parameters that can predict whether a particular NO—X candidate is capable of producing desirable therapeutic effects, e.g. enhanced anti-inflammatory activity, reduced intestinal, cardiac and renal toxicity. Accordingly, the present invention can greatly enhance proper selection of an appropriate candidate for drug development, thereby minimizing development time and conserving costs. | 11-20-2008 |
20080294348 | BIOLOGICAL INFORMATION MEASUREMENT DEVICE AND METHOD OF MEASURING BIOLOGICAL INFORMATION SUITABLE FOR REGULAR MEASUREMENT OF BIOLOGICAL INFORMATION - A biological information measurement device stores, in a storage unit, biological data representing data of calculated biological information and measurement date data in association with each other. The biological information measurement device displays, as measurement frequency specifying information, information for specifying frequency of day(s) when the measurement was conducted, in a prescribed period from a current date based on a plurality of pieces of measurement date data stored in the storage unit and an output from a time keeping unit. | 11-27-2008 |
20080294349 | Quantitative Evaluation and Image Analysis of Choroidal Neovascular Membrane and Other Retinal and Subretinal Lesions - The present invention can be a method to allow a user to extract and calculate objective data in a reproducible indicator of the initial evaluation, progression or regression of the activity of choroidal neovascularization or other retinal and subretinal lesions summarized as a single number. The method can be applied to either OCT, FA or both as diagnostic tools depending upon the preference of the user and can be used as the steps of Data Collection, Data and Image Analysis, and Computations. The present invention further provides a user a formula for Approximate Lesion Volume, Flourescein index, the change in the flourescein index, lesion volume index, the active lesion volume change, or the regression factor as well as the severity index. The present invention can also be automated in a program to calculate the desired indexes for the user. | 11-27-2008 |
20080294350 | PERFORMING DATA ANALYSIS ON CLINICAL DATA - Reference intervals are established and/or validated based on existing clinical data and exclusion criteria, such as diagnosis coding. A Reference Interval Test Engine is designed to statistically analyze large volumes of existing clinical lab test results to establish and evaluate reference intervals for specific population subgroups and/or to provide other applications. | 11-27-2008 |
20080294351 | METHOD FOR PREDICTING SECONDARY STRUCTURE OF NUCLEIC ACID SEQUENCE, A PREDICTOR FOR SECONDARY STRUCTURE OF NUCLEIC ACID SEQUENCE AND A PREDICTING PROGRAM FOR PREDICTING SECONDARY STRUCTURE OF NUCLEIC ACID SEQUENCE - An exemplary object of the present invention is to provide method, predictor and predicting program for predicting secondary structure of nucleic acid sequence capable of evaluating not only overall similarity and but also localized similarity of secondary structure of nucleic acid sequence. A method according to an exemplary aspect of the present invention includes the steps of: | 11-27-2008 |
20080300794 | SYSTEM, METHOD, APPARATUS AND COMPUTER PROGRAM PRODUCT FOR CAPTURING HUMAN-READABLE TEXT DISPLAYED ON A UNIT DOSE PACKAGE - A system, method, apparatus and computer program product are provided for capturing human-readable text displayed on a unit dose package. In particular, identification information associated with a unit dose package may be used to determine a location and/or a format in which human-readable text, such as an expiration date or lot number associated with the corresponding unit dose medication, is displayed on the unit dose package. Once the location and/or format of the human-readable text has been determined, this information can be used in order to scan the unit dose medication and translate the human-readable text into machine-readable text using, for example, optical character recognition. | 12-04-2008 |
20080300795 | Evaluating the probability that MS/MS spectral data matches candidate sequence data - In one aspect of the present invention a new database search methodology is provided that provides a probability that spectral data from a non-ergodic reaction via mass spectrometry matches a candidate sequence from a set of sequences in a database by random. The methodology comprises two parts. The first part pre-processes the spectral data and retains only the most relevant data for the database search. The second part comprises searching a database using the pre-processed spectrum to assign a probability or expectation that the spectrum matches a candidate sequence from a set of sequences in a database by random. The search methodology uses a new probability model, a compound distribution based on the number of product ion mass-to-charge ratios and the number of intensity values that are shared between the product ion spectral data and the sequence database, to accurately predict the probability of the peptide identification being a correct match, and not a random event. | 12-04-2008 |
20080300796 | BIOLOGICAL ANALYSIS METHODS, BIOLOGICAL ANALYSIS DEVICES, AND ARTICLES OF MANUFACTURE - Biological analysis methods, biological analysis devices, and articles of manufacture are described. Biological analysis methods access data regarding one or more images of a plurality of different combinations of biological receptors which individually have reacted with one or more biological indicators of a biological sample, analyze the data, and based on the analysis, create a profile comprising values representative of the biological indicators. Other biological analysis methods first access a plurality of first values individually corresponding to a plurality of biological indicators of a first subject, second access a plurality of second values individually corresponding to a plurality of biological indicators of a second subject, analyze the first and second values with respect to one another, and provide information regarding similarity of the first subject and the second subject using the analysis. | 12-04-2008 |
20080300797 | TWO BIOMARKERS FOR DIAGNOSIS AND MONITORING OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE - The present invention identifies two circulating proteins that have been newly identified as being differentially expressed in atherosclerosis. Circulating levels of these two proteins, particularly as a panel of proteins, can discriminate patients with acute myocardial infarction from those with stable exertional angina and from those with no history of atherosclerotic cardiovascular disease. Such levels can also predict cardiovascular events, determine the effectiveness of therapy, stage disease, and the like. For example, these markers are useful as surrogate biomarkers of clinical events needed for development of vascular specific pharmaceutical agents. | 12-04-2008 |
20080300798 | CARDIBIOINDEX/CARDIBIOSCORE AND UTILITY OF SALIVARY PROTEOME IN CARDIOVASCULAR DIAGNOSTICS - Embodiments of the invention include methods by which cardiac biomarkers are assigned an index (cardiovascular biomarker index-cardiobioindex, CBI) as a means to describe the utility of each biomarker, or combination of biomarkers for risk evaluation, diagnosis or prognosis of cardiovascular disease status. | 12-04-2008 |
20080300799 | System And Method For Multiple-Factor Selection - The disclosed subject matter provides techniques for multiple-factor selection. The factors can be features or elements that are jointly associated with one or more outcomes by their joint presence or absence. There may be a non-causative correlation between the factors, features, or elements and the outcomes. In some embodiments, Entropy Minimization and Boolean Parsimony (EMBP) is used to identify modules of genes jointly associated with disease from gene expression data, and a logic function is provided to connect the combined expression levels in each gene module with the presence of disease. The smallest module of genes whose joint expression levels can predict the presence of disease can be identified. | 12-04-2008 |
20080306694 | Methods for Detecting Peaks in a Nucleic Acid Data Trace - The present invention relates to methods and apparatus for detecting peaks in a sample nucleic acid data trace derived from a sample polynucleotide by (a) receiving a sequence signature of a reference polynucleotide, wherein the sequence signature comprises a profile of peak height at one or more peak position of a nucleic acid sequence data trace of one or more of reference polynucleotides; (b) receiving a sample nucleic acid sequence data trace of a sample polynucleotide corresponding to the reference polynucleotide, wherein the sample nucleic acid sequence data trace comprises a value of peak height at one or more peak position corresponding to the peak positions of the sequence signature; and (c) detecting peaks in the sample nucleic acid data trace having a peak height that correlates with the profile of peak height of the sequence signature at a corresponding peak position. | 12-11-2008 |
20080312840 | Method for Affinity Scoring of Peptide/Protein Complexes - The present invention is related to a quantitative structure-based affinity scoring method for peptide/protein complexes. More specifically, the present invention comprises a method that operates on the basis of a highly specific force field function (e.g. CHARMM) that is applied to all-atom structural representations of peptide/receptor complexes. Peptide side-chain contributions to total affinity are scored after detailed rotameric sampling followed by controlled energy refinement. The method of the invention further comprises a de novo approach to estimate dehydration energies from the simulation of individual amino acids in a solvent box filled with explicit water molecules and applying the same force field function as used to evaluate peptide/receptor complex interactions. | 12-18-2008 |
20080312841 | Method and apparatus for providing data processing and control in a medical communication system - Methods and apparatus for providing data processing and control for use in a medical communication system are provided. | 12-18-2008 |
20080312842 | Method and apparatus for providing data processing and control in a medical communication system - Methods and apparatus for providing data processing and control for use in a medical communication system are provided. | 12-18-2008 |
20080319676 | Absolute Quantitation of Protein Contents Based on Exponentially Modified Protein Abundance Index by Mass Spectrometry - The present inventor has established protein abundance index (PAI, π) to determine the protein contents in a protein mixture solution using nanoLC-MSMS data. Digested peptides were analyzed by nanoLC-MS/MS and the obtained results were applied to a Mascot protein identification algorism based on tandem mass spectra. PAI is defined as the number of observed peptides divided by the number of observable peptides per protein. PAI from different concentrations of serum albumin showed linear relationship to the logarithm of the protein concentration. This was also valid for 47 proteins in a mouse whole cell lysate analyzed by single run of nanoLC-MS/MS. On the other hand, Mascot protein scores as well as the number of identified peptides per protein were less correlated to the protein abundance. For absolute quantitation, PAI was converted to exponentially modified PAI (EMPAI, mπ), which is proportional to protein contents in the protein mixture. For the 47 proteins in the whole lysate, the deviation percentages of the EMPAI-based concentrations to the actual values were within 63% in average. EMPAI was successfully applied to comprehensive protein expression analysis and performed a comparison study between gene and protein expression in an HCT116 human cancer cells. Accordingly, the present invention provides a method and a computer program for quantifying the protein contents based on the protein abundance index. | 12-25-2008 |
20080319677 | Systems and Methods for Designing Molecules with Affinity for Therapeutic Target Proteins - The present invention provides methods for designing molecules with affinity for target proteins. More particularly, the present invention provides systems and methods for docking fragment molecules to target protein binding sites. The systems and methods are useful for designing active molecules in drug discovery. Methods of this invention can be implemented in a computer system and may be embodied as computer code in a computer readable medium. | 12-25-2008 |
20080319678 | Mass Tagging for Quantitative Analysis of Biomolecules using 13C Labeled Phenylisocyanate - The present invention provides novel compositions and methods for mass-tagging peptides and proteins which are useful for identifying and quantifying mixtures of peptides and proteins. | 12-25-2008 |
20090006001 | EMPIRICAL QUANTITATIVE APPROACHES FOR PSYCHIATRIC DISORDERS PHENOTYPES - Psychiatric phenotypes as currently defined are primarily the result of clinical consensus criteria rather than empirical research. A novel approach to characterizing psychiatric phenotypes is presented herein, termed PhenoChipping. A massive parallel profiling of cognitive and affective state is done with a PhenoChip composed of a battery of existing and new quantitative psychiatric rating scales, as well as hand neuromotor measures. Phenotypic overlap among, as well as phenotypic heterogeneity within, the three major psychotic disorders studied were demonstrated. Empirically derived clusterings of (endo)phenotypes and of patients serve genetic, pharmacological, and imaging research, as well as clinical practice. | 01-01-2009 |
20090012713 | Methods of Assessing Cognitive Dysfunction - This invention relates to methods and means for assessing cognitive dysfunction, in particular impulsivity associated cognitive dysfunction, which may for example include Attention Deficit Hyperactivity Disorder (ADHD), substance abuse, and non-toxic addictive/compulsive behaviour. A method may comprise displaying a population of elements to the individual and allowing the sequential selection of elements within the population by the individual. The selection of an element reveals to the individual a characteristic of the selected element which is one of a number of possible characteristics of elements in said population. The sequential selection ends when the individual chooses which of the possible characteristics is possessed by the most elements in the population. The number of elements selected by the individual in making this choice is then correlated to the likelihood that the individual has impulsivity associated cognitive dysfunction. | 01-08-2009 |
20090012714 | Test of amino acid sequence constituting peptide using isotopic ratio - It is an object of the present invention, when determining and identifying an amino acid sequence of a peptide using MS, to obtain additional information from the MS for evaluating validity of an amino acid sequence in a candidate list outputted from an identifying engine. The present invention provides a method of testing an amino acid sequence inferred by searching a peptide-related database based on peptide mass information and/or peptide modification information obtained through mass spectrometry on a peptide, the method comprising the steps: (1) calculating a theoretical value of an isotopic ratio for the peptide from the inferred amino acid sequence and/or the peptide modification information; (2) measuring a measured value of the isotopic ratio for the peptide from the peptide mass information; and (3) comparing the theoretical value and the measured value, and evaluating validity of the inferred amino acid sequence from differences between the theoretical value and the measured value. | 01-08-2009 |
20090012715 | Prediction model of graft survival - Described are methods of predicting graft survival based on pre-transplant variables. A logistic regression (LM) and/or a tree-based model (TBM) are used to identify predictors of graft survival and to generate prediction algorithms. Both the logistic regression model and the tree-based model may be used in clinical practice for long term prediction of graft survival based on pre-transplant variables. The invention is also directed to computer software, which includes a logistic regression model and/or a tree-based model to select pre-transplant variables and generate a graft survival algorithm and to calculate a graft survival probability, and for selecting appropriate organ donors and recipients to optimize the graft survival probability. | 01-08-2009 |
20090012716 | Diabetes-related biomarkers and methods of use thereof - The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes. | 01-08-2009 |
20090012717 | Method For Determining Drug-Molecular Combinations That Modulate And Enhance The Therapeutic Safety And Efficacy Of Biological Or Pharmaceutical Drugs - A method that creates a new class of pharmaceutical combinations (specific ratio combinations) that offer an improved therapeutic profile with reduced side effects is provided. Safer, more cost-effective drugs for treating various diseases or medical conditions are created by combining receptor activating, inhibiting or modulating drugs in specific ratio combinations that optimize the therapeutic profiles for various pharmaceutical compositions. The method demonstrates how to combine biological or pharmaceutical molecules or drugs in order to create specific ratio combinations that are optimized to improve the overall safety and therapeutic efficacy of the individual molecules or drugs alone. These techniques create novel receptor-activating drugs that are anticipated to prove useful for future therapeutic treatments. | 01-08-2009 |
20090012718 | Nuclear Medicine Diagnosis Apparatus and Diagnostic System Used Thereto - The function of an accumulated amount deriving part | 01-08-2009 |
20090018776 | SYSTEM AND METHOD FOR NORMALIZING DATA IN NUCLEIC ACID AMPLIFICATION PROCEDURES - The present invention provides systems and methods for normalizing data in nucleic acid amplification procedures. In general, the methods include: obtaining input from a user regarding a number of normalizer measurements to use in calculations; obtaining raw fluorescence measurements of one or more probe(s) over multiple cycles of the procedure; obtaining normalizer measurement(s); and normalizing the probe data using the normalizer measurement(s) specified by the user. The present invention also discloses software and a computer readable medium for carrying method steps of the invention. Reduced cycle times, decreased variability, and/or lower Ct values are obtained as a result of the normalization. | 01-15-2009 |
20090018777 | Systems and Methods for Predicitng Ligand-Protein Binding Interactions - The present invention relates to systems and methods for determining a candidate molecule's ability to bind a target protein comprising calculating a score for the candidate molecule, wherein the score is a function of a position of the candidate molecule relative to a field of distribution densities on a three-dimensional target protein structure. The systems and methods are useful for designing active molecules in drug discovery. Methods of this invention can be implemented in a computer system and may be embodied as computer code in a computer readable medium. | 01-15-2009 |
20090018778 | Method Related to Gestation Periods - The present invention relates generally to a method for estimating the time elapsed within a gestation period of a pregnant or potentially pregnant ruminant, such as a cow. The method involves estimating the time elapsed within a gestation period of a pregnant or potentially pregnant ruminant, including the steps of providing a sample from the ruminant; calculating a value of a pregnancy indicator in the sample; and applying a regression formula to the value of the pregnancy indicator to provide an estimate of the time elapsed within the gestation period. The method may further include the steps of categorising the pregnancy status of the ruminant, qualitatively assessing the level of the pregnancy indicator value for application thereto of the regression formula, using the time elapsed to derive an estimate of a gestation-related event, and validating the estimated date of a gestation related event. The invention further provides computer software to generate an estimate of the time elapsed within a gestation period of a pregnant ruminant, and systems for generating an estimate of the time elapsed. | 01-15-2009 |
20090018779 | Flexible glucose analysis using varying time report deltas and configurable glucose target ranges - A diabetes data management system selects variable threshold parameters to that are utilized in a report. A first low threshold glucose reading and a first high threshold glucose reading for a before meal event timeframe are selected. A second low threshold glucose reading and a second high threshold glucose reading are selected for an after meal event timeframe. The threshold readings are stored in a database. The diabetes data management system analyzes glucose behavior around meal events. The system receives a plurality of glucose readings for a time period, receives a first time range as a pre-meal analysis period for the first meal event and receives a second time range as a post-meal analysis period for the first meal event. The system creates a graph which highlights the pre-meal analysis period, the post-meal analysis period, and displays the plurality of glucose readings for the time period. | 01-15-2009 |
20090024329 | Methods and systems relating to epigenetic information - The present application relates, in general, to a system or method for detection or treatment. In some aspects, a system includes at least one computer program for use with at least one computer system and wherein the computer program includes a plurality of instructions including, but not limited to, one or more instructions for determining at least one correlation between at least one aspect of epigenetic information regarding at least one individual and information regarding at least one clinical outcome following receipt by the at least one individual of at least one medical therapy. | 01-22-2009 |
20090024330 | METHODS AND SYSTEMS RELATING TO EPIGENETIC PHENOTYPES - In one aspect, a system includes, but is not limited to, at least one computer program for use with at least one computer system and wherein the computer program includes a plurality of instructions, including but not limited to, one or more instructions for determining at least one correlation between at least one epigenetic-influencing event and at least one aspect of epigenetic phenotype information regarding at least one individual. | 01-22-2009 |
20090024331 | METHODS AND PROCESSES FOR CALLING BASES IN SEQUENCE BY INCORPORATION METHODS - Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof. | 01-22-2009 |
20090024332 | DIAGNOSING INAPPARENT DISEASES FROM COMMON CLINICAL TESTS USING BAYESIAN ANALYSIS - A system and method of diagnosing diseases from biological data is disclosed. A system for automated disease diagnostics prediction can be generated using a database of clinical test data. The diagnostics prediction can also be used to develop screening tests to screen for one or more inapparent diseases. The prediction method can be implemented with Bayesian probability estimation techniques. The system and method permit clinical test data to be analyzed and mined for improved disease diagnosis. | 01-22-2009 |
20090030617 | Biosensor Calibration System - A biosensor system determines an analyte concentration using one or more calibrated correlation equations for an optical and/or electrochemical analysis of a biological fluid. The biosensor system may be implemented using a measurement device and a sensor strip. The measurement device senses circuit patterns on an encoding pattern of the sensor strip. The measurement device determines calibration information in response to the circuit patterns, and uses the calibration information to calibrate one or more of the correlation equations. The measurement device uses the calibrated correlation equations to determine the analyte concentration. | 01-29-2009 |
20090030618 | SYSTEM, METHOD AND SOFTWARE ARRANGEMENT FOR ANALYZING AND CORRELATING MOLECULAR PROFILES ASSOCIATED WITH ANATOMICAL STRUCTURES - A system, method and software arrangement according to exemplary embodiments of the present invention are provided which can use molecular profiles obtained from unaltered human tissue specimens for clinical purposes including disease diagnoses and treatment evaluations. For example, spatial distributions of chemical species including metabolites within the tissue may be obtained using radiological techniques such as magnetic resonance spectroscopy imaging. Disease-specific profiles may be obtained by comparing the distributions of chemical species obtained in ex vivo tissues with pathological observations made on them using statistical analysis. The disease-specific profiles may then be correlated with in vivo or ex vivo molecular profiles to obtain spatial maps that can provide a more sensitive and accurate detection of diseased tissue. Thus, such exemplary systems, methods and software arrangements can include the ability to receive information relating to the distribution of at least three chemical species in the tissue of interest, compare this information statistically to a predetermined profile and, based on the statistical correlation between the information and the profile, determine certain characteristics of the tissue of interest such as, e.g., the presence or absence of diseased tissue. | 01-29-2009 |
20090030619 | VEHICULAR USER HOSPITALITY SYSTEM - A vehicular user hospitality system recognizes a situation concerning vehicle use according to a combination of a disturbance stimulation type and hospitality intention category. With an intention estimation table, the system determines a reference intention parameter value for providing an intensity reference of a hospitality intention for each of safety, convenience, and comfort categories. The system settles an intention intensity reference using a reference intention parameter value specific to each situation. The system supplements the reference intention parameter value with the current disturbance stimulation value to determine an intention intensity parameter value to be appropriately used as a function selection reference value while considering a disturbance stimulation magnitude. Using a function specification table, function specification information for specifying a function of a hospitality operating portion is extracted according to a combination of the disturbance stimulation type and the hospitality intention category to thereby determine a control content. | 01-29-2009 |
20090037116 | SYSTEMS, DEVICES, AND METHODS FOR ANALYZING MACROMOLECULES, BIOMOLECULES, AND THE LIKE - Systems, devices, and methods for analyzing hybridization of target molecules to probes on substrate-bound oligonucleotide, peptide, or protein arrays. In one aspect, the system includes a computer-readable memory medium and a controller. The system may further include a computer-readable memory medium including thermodynamic data configured as a data structure for use in analyzing biological samples. In some embodiments, the data structure comprises a thermodynamic data section having: thermodynamic data representative of dangling ends of two or more bases; thermodynamic data representative of unpaired single strands of two or more bases adjacent to a Watson-Crick base pairing; thermodynamic data representative of unpaired single strands of one or more bases adjacent to a non-Watson-Crick base pairing; thermodynamic data representative of tandem base pair mismatches of two or more bases; thermodynamic data representative of length-dependent terminal mismatches of nucleic acid bases; thermodynamic data representative of terminal base pair mismatches, or combinations thereof. | 02-05-2009 |
20090043512 | Structure-sequence based analysis for identification of conserved regions in proteins - Disclosed are computational methods, and associated hardware and software products for scoring conservation in a protein structure based on a computationally identified family or cluster of protein structures. A method of computationally identifying a family or cluster of protein structures in also disclosed herein. | 02-12-2009 |
20090043513 | METHODS AND APPARATUS FOR CHARACTERIZING POLYMERIC MIXTURES - The invention provides methods and apparatus for characterizing complex polymeric mixture of interest. Candidate solutions are eliminated from a solution space using one or more experimental measurements of a polymeric mixture of interest. The elimination step can be repeated one or more times using different experimental measurements produced by various chemical and physical protocols, so that the remaining candidate solutions converge to describe the actual polymeric mixture under investigation. Once the composition of the complex polymeric mixture has been characterized, the information thus generated can be used to facilitate, for example, the manufacture of a bio-equivalent of the complex polymeric mixture. | 02-12-2009 |
20090055099 | Proteomic analysis of biological fluids - The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and maturation. In particular, the invention concerns the identification of the proteome of amniotic fluid (multiple proteins representing the composition of amniotic fluid) and the correlation of characteristic changes in the normal proteome with various pathologic maternal/fetal conditions, such as intra-amniotic infection, or chromosomal defects. | 02-26-2009 |
20090055100 | METHOD FOR IDENTIFYING AND/OR CHARACTERIZING A (POLY)PEPTIDE - The present invention relates to a method for identifying and/or characterizing a (poly)peptide comprising: (a) analyzing a peptide map of said (poly)peptide, comprising at least 1 peptide, and its peptide primary structure fingerprint by mass spectrometry; and (b) comparing data obtained in step (a) with a reference (poly)peptide database, said database comprising mass spectrometric data of peptide maps, comprising at least 1 peptide, and of its peptide primary structure fingerprint, of a (poly)peptide or of a variety of (poly)peptides. | 02-26-2009 |
20090055101 | METHOD FOR ESTIMATING MOLECULE CONCENTRATIONS IN A SAMPLING AND EQUIPMENT THEREFOR - This method for estimating molecule concentrations in a measurement line that can include a liquid phase chromatographic column or a mass spectrometry is based on statistical calculations to transform, in an analytical model of the received signal, the factors (measured results or measurement parameters) into probability distributions from a priori estimations. The final values of the results are inferred from a parameter, such as the average, of these probability distributions. The method is excellent in properly assessing measurement peaks in signals with noise or superimposed with other peaks, which is not carried out properly by conventionally peak analysis or spectral analysis methods. | 02-26-2009 |
20090063056 | System integrating machine vision, interactive module and rehabilitation equipment - A system integrating machine vision, interactive module and rehabilitation equipment primarily comprises a rehabilitation equipment, at least one image-capture device for continuously capturing images of specific limbs or a trunk of a user operating the rehabilitation equipment so as to generate digital image data, and a machine vision recognition unit for processing the digital image data into characteristic image data that can be analyzed and applied by a host computer belonging to the machine vision recognition unit. Then, the host computer can transform the characteristic image data into direction signals and velocity signals with respect to movements of the user's limbs and trunk and afterward output the signals to an interactive module. | 03-05-2009 |
20090070044 | Two-Body Interaction Calculation Circuit and Many-Body Problem Calculation Device that Uses this Circuit - The object of the present invention is to provide both a two-body interaction calculation circuit that can reduce the number of arithmetic elements of a circuit for virial calculation and that can decrease circuit scale and a many-body problem calculation device that uses this two-body interaction calculation circuit, the two-body interaction calculation circuit of the present invention including: a coordinate difference calculation unit for receiving as input coordinates of center particles i, the size of a basic cell, lattice vectors, and coordinates of particles j and for calculating the difference between coordinates of a center particle i and coordinates in which the coordinates of a particle j have been converted to a mirror-image particle; a distance-squaring calculation unit for calculating the square of distances based on the difference; a function calculation unit for calculating an interaction function that depends on distance based on the square of distance; a force calculation unit for calculating force from the interaction function and the difference; a sum-total calculation unit for calculating the sum-total of force for particles i based on force; and a virial calculation unit for calculating virials based on the sum-total of force. | 03-12-2009 |
20090070045 | DIAGNOSIS SUPPORTING SYSTEM - A diagnosis supporting system ( | 03-12-2009 |
20090076731 | METHOD AND DEVICE AND PREDICTING PHYSIOLOGICAL VALUES - The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject. | 03-19-2009 |
20090076732 | SYSTEMS AND METHODS FOR THE ANALYSIS OF MECHANICAL PROPERTIES OF MATERIALS - The various embodiments of the present invention relate generally to the analysis of the mechanical properties of materials. More particularly, the various embodiments of the present invention relates to systems and methods of deriving the static and dynamic mechanical properties of deformative materials, for example, but not limited to, biological surfaces. The systems and methods of the present invention can be used to derive and evaluate the mechanical properties of many biological surfaces and subsurfaces, including but not limited to the skin. | 03-19-2009 |
20090076733 | Water Toxicity Detecting Apparatus and Method Using Sulfur Particles - Provided are a water toxicity detecting apparatus and a method using sulfur particles. The water toxicity detecting apparatus using sulfur particles includes: a reaction container containing microbes, in which externally-supplied sulfur particles and oxygen are reacted to form sulfate ions by the microbes; a water sample inlet through which a water sample is flown into the reaction container; an air inlet through which an air is flown into the reaction container; a first detection unit which detects pH and electrical conductivity of the inflow water sample flown through the water sample inlet; a second detection unit which detects pH and electrical conductivity of the water sample containing the sulfate ions generated in the reaction container; a central processing unit which stores data of the ph and electrical conductivity of the inflow water sample flown through the water sample inlet, adjusts a pumping speed of a pump provided to the water sample inlet and a flow rate of the air, and compares data of the first detection unit with data of the second detection unit to determine presence of toxicity of the water sample; and an outlet through the after-toxicity-test water sample is exhausted from the reaction container. | 03-19-2009 |
20090082971 | COMBINED IMAGE PROCESSING COMPUTER FOR MEDICAL DIAGNOSTICS IN THE FIELDS OF RADIOGRAPHY AND FLUOROSCOPY - A combination radiography and fluoroscopy system includes in one embodiment a radiography radiation generator and radiography radiation receiver, a fluoroscopy radiation generator and fluoroscopy radiation receiver, and a single computer system connected to receive signals from the radiography radiation receiver and fluoroscopy radiation receiver. The single computer system includes signal processing paths for the radiography signal and for the fluoroscopy signal wherein some processes or modules are common between the paths and some are path specific. The path specific processes are preferably connected in parallel. Common controls and a common interface are provided to the monitor connected to the computer system. An alternative uses a single radiation receiver for both radiography and fluoroscopy, along with the single computer system Another alternative provides for separate computers for signal processing of the radiography and fluoroscopy signals, the two computers running substantially identical signal processing programs. | 03-26-2009 |
20090082972 | CODING PATTERN HAVING CELL TRANSLATIONS IDENTIFIABLE IN DIFFERENT ORIENTATIONS - A substrate having a coding pattern disposed on a surface thereof. The coding pattern comprises: a plurality of target elements defining a target grid; a plurality of data elements contained in each cell of the grid; and a plurality of tags. Each tag is defined by a plurality of contiguous cells and comprises respective tag data encoded by data elements. Each cell comprises a pair of registration symbols, each encoded by a respective set of the data elements. The set of data elements identifies a translation of the cell relative to a tag containing the cell. Further, each set of data elements maps to a first translation code symbol value when read in a first orientation, and maps to a second translation code symbol value when read in a second orientation. Thus, the translation of the cell relative to the tag is identifiable in either of the first or second orientations. | 03-26-2009 |
20090082973 | ANALYSIS SYSTEM FOR DETERMINING AN ANALYTE IN A BODY FLUID - An analysis system for determining an analyte of a body fluid comprises a test element and an analysis instrument having a measurement and evaluation unit. The test element has a sample application zone and two analysis zones and a reagent system, whose reaction with the analyte results in a detectable change characteristic for the desired analytical result. The measurement and evaluation unit comprises two analog measuring units, in each of which an analog measurement signal corresponding to one of the analysis zones is generated, two analog-digital converters for digitizing the analog measurement signal, a comparator unit for comparing control data values based on the digitized measurement signals, and a final processing unit, in which, if the determined deviation between the control data values of the digitized measurement signals is less than a predefined value, at least one of the control data values is allowed to pass for further processing into the desired analytical result. | 03-26-2009 |
20090082974 | Methods and systems for treating disease - Methods and systems described herein are applicable to the identification of pathogens, pathogenic variants and applicable treatments or remedies. In some embodiments, the pathogen or pathogens bears a causal relationship to a disease state. | 03-26-2009 |
20090088981 | Methods And Systems Of Dynamic Screening Of Disease - The present invention provides methods and systems for dynamic screening of disease in a subject. The information provided by the methods and systems can be used for many purposes including disease diagnosis and screening, disease treatment, and education the subject of life choices. | 04-02-2009 |
20090093966 | Hybridization data processing method using probe array - A data processing method of reducing signals to numerical values and processing the numerical values are provided. The signals are obtained by using a probe array where probes of a plurality of kinds are immobilized on a solid phase as so many spots such that a plurality of spots of probes of one kind are arranged on the solid phase and causing the array to react with a target substance. The method comprises ( | 04-09-2009 |
20090093967 | GENOME ANALYSIS SYSTEM II - The present invention provides that the analysis can be estimated the characteristics of the originated populations which belong to the samples and the characteristics of the samples from sample data. By loading the sample data, by interfering with the second state variable showing the characteristics in the environment system to the first state variable showing the characteristics in the objective system, by converging the variable by selecting the maximum resonant state, and by estimating the characteristics of the samples and the characteristics of the originated populations which belong to the samples, then the result estimated the characteristics of the originated populations is outputted. | 04-09-2009 |
20090093968 | ANALYSIS DEVICE AND ANALYSIS METHOD - In an analysis device for measuring a target substance in a liquid sample, highly precise measurement cannot be realized because reliability of measurement is degraded due to influences of properties of the liquid sample and an analysis element. | 04-09-2009 |
20090093969 | Computer-Aided Discovery of Biomarker Profiles in Complex Biological Systems - The invention relates to computational methods, systems and apparatus useful in the analysis of sets of biomolecules in an accessible body fluid or tissue sample from a patient, which biomolecules collectively or individually are candidates to serve as biomarkers, i.e., biomolecules which together or individually upon detection or change are indicative that the patient is in some biological state, such as a diseased state. The methods permit one to examine such potential biological markers to determine whether each one is indeed present as a consequence of the biological state, or as an artifact of the biomarker search protocol. | 04-09-2009 |
20090099780 | HEALTHCARE DEVICE AND COMPREHENSIVE MEASUREMENT METHOD USING THE SAME - A healthcare device and a method using the same are disclosed. The healthcare device includes a biological data measuring module, a conversion module for amplifying data measured by the biological data measuring module by using a non linear function, a biological data input module for inputting a conversion data converted by said conversion module or for inputting a measuring data measured by a Chinese or a western medical device, a healthcare classification module for generating different healthcare classification data according to comparison of data inputted by the biological data input module, and a biological performance module for converting the classified healthcare clue into an energy distribution data or a mentality level data by using a non linear function. | 04-16-2009 |
20090099781 | METHOD AND SYSTEM FOR ESTIMATING A BLOOD SUGER CONDITION - A blood sugar condition is estimated by (1) measuring a urine sugar value A, (2) discriminating whether or not the measured urine sugar value is less than a discriminating method classification boundary value, (3) when it is less, obtaining an averaged value X of measured urine sugar values during a past predetermined period of time, measured at the same timing in a one-day life as the timing when the latest measured urine sugar value is measured, (4) calculating the difference between the averaged value and the measured urine sugar value, (5) when the difference is not less than a positive discriminating reference difference, discriminating as being a blood sugar value decrease, (6) when the measured urine sugar value A is not less than the discriminating method classification boundary value, obtaining an averaged value X of all measured urine sugar values during the past predetermined period of time, (7) calculating a ratio between the measured urine sugar value and the averaged value X, and, (8) when the ratio is not greater than a first discriminating reference ratio, discriminating as being the blood sugar value decrease. | 04-16-2009 |
20090099782 | AUTOMATIC ANALYZING METHOD AND APPARATUS FOR MICROFLUIDIC SYSTEM - Provided are an automatic analyzing method and apparatus for a microfludic system. The apparatus includes means for recognizing a disc or chip in the microfludic system, performs an operation and detection by automatically loading a DB according to a recognized type, and perform quantitation of a test. | 04-16-2009 |
20090099783 | Stage Specific Prognostic In Vivo Markers of Brain Aging and Dementia - A method for the identification of treatments and preventative agents for brain aging, subjective cognitive impairment (SCI), mild cognitive impairment (MCI), Alzheimer's disease (AD) and other degenerative dementias, the method including (a) the identification of the diagnosis and stage of the subject, (b) the identification of the duration of the stage of the condition and/or disorder, (c) the identification of prognostic markers based upon a formula incorporating the duration of the condition and/or stage, (d) the prospective separation of prognostic subgroups based upon outcome wherein the outcome is defined in these conditions as progression to a subsequent stage or stages, (e) the employment of a putative prognostic marker for an appropriate period of time, based upon the formula incorporating the duration of the condition and/or stage, (f) the application of in vivo, methodology specific techniques, in conjunction with stage specific prognostic subgroups, for the appropriate time period, for the identification, prospectively, of useful markers, (g) the employment of these markers to identify useful therapeutic agents for prevention and treatment. | 04-16-2009 |
20090099784 | SOFTWARE ASSISTED METHODS FOR PROBING THE BIOCHEMICAL BASIS OF BIOLOGICAL STATES - The present invention relates to computational methods, systems and apparatus useful in the identification of similarities and/or differences between a plurality of biological states, such as altered biological states in an animal (e.g., a mammal or human). Particularly, the invention relates to comparing two or more causal system models (“CSMs”) which each are indicative of a biological state, such as a disease state, a toxic state, or a drug- or therapy-induced state. The present invention also relates to generating a general CSM from a comparison of two or more other CSMs, and subsequently comparing one or more of the other CSMs to the general CSM. Either of these techniques, or a combination of the two techniques, can be used to identify unique and common features in each CSM. | 04-16-2009 |
20090099785 | INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND STORAGE MEDIUM - An information processing apparatus includes a management section configured to manage biological rhythm information about a user, and a display control section configured to display the biological rhythm information so as to be associated with an object corresponding to the user. | 04-16-2009 |
20090099786 | BIOPOLYMER SEQUENCING BY HYBRIDIZATION OF PROBES TO FORM TERNARY COMPLEXES AND VARIABLE RANGE ALIGNMENT - Methods for sequencing a biopolymer by forming local ternary complexes along the length of the double-stranded biopolymer target molecule using one or more probes and obtaining information about the location of the probe(s) using a detector. These methods offer particular advantage when implemented with nanopore (including micropore) detection systems. | 04-16-2009 |
20090099787 | Abnormal Output Detection System For A Biosensor - A biosensor has an abnormal output detection system that determines whether an output signal from the redox reaction of an analyte has a normal or abnormal shape or configuration. The abnormal output detection system improves the accuracy and precision of the biosensor in determining whether an output signal has a shape or configuration that may not provide an accurate and/or precise analysis of a biological fluid. The biosensor generates an output signal in response to the redox reaction of the analyte. The biosensor normalizes the output signal and compares the normalized output signal with one or more control limits. The biosensor may generate an error signal when the normalized output signal is not within the control limits. | 04-16-2009 |
20090099788 | PROTEIN STRUCTURE ANALYSIS - Techniques for analyzing one or more protein structures. In one aspect of the invention, the technique comprises the following steps. A normalized second-order hydrophobic moment is determined for a protein structure. The normalized second-order hydrophobic moment is then used for analysis of the protein structure. A scoring function in accordance with the normalized second-order hydrophobic moment for the protein structure may be determined. A score for the protein structure may then be generated using the scoring function. The scoring function may represent an integral of the normalized second-order hydrophobic moment. The scores may be generated for a plurality of protein structures. The scores generated for the plurality of protein structures may then be compared. | 04-16-2009 |
20090105958 | Method for skeletal maturity determination - The invention is a method for estimating a skeletal maturity value of a human from a radiograph of one or more bones in the hand. The borders of the bones are represented by shape points, which are subjected to principal component analysis (PCA). Image intensities are sampled at points located relative to the shape point, and also compressed with PCA. From the features a skeletal maturity value is determined. | 04-23-2009 |
20090105959 | System and method for identification of individual samples from a multiplex mixture - An embodiment of an identifier element for identifying an origin of a template nucleic acid molecule is described that comprises a nucleic acid element comprising a sequence composition that enables detection of an introduced error in sequence data generated from the nucleic acid element and correction of the introduced error, where the nucleic acid element is constructed to couple with the end of a template nucleic acid molecule and identifies an origin of the template nucleic acid molecule. | 04-23-2009 |
20090105960 | Device for supporting diagnosis of a cancer and a device for predicting an effects of anthracycline anticancer drugs - A device for supporting a diagnosis of a cancer which provides information useful to decide whether or not an anthracycline anticancer drug should be administered to a cancer patient to be examined is disclosed. Concretely, the device is composed to be able to acquire an activity and an expression of two cyclin dependent kinases (CDK) from a malignant tumor of a cancer patient to be examined, and to acquire a CDK parameters from both of two CDKs. Furthermore the device determines sample data comprising predetermined CDK parameter, and display information of determined sample data. According to the above component, user is easily able to know whether or not a cancer of a cancer patient, whose tumor is similar to the tumor of the cancer patient to be examined, has been recurred in spite of an administration of an anthracycline anticancer drug. | 04-23-2009 |
20090112478 | Modified Sensor Calibration Algorithm - A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals, obtaining reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals, calculating the calibration characteristics using the reference glucose values and corresponding glucose monitor data to regress the obtained glucose monitor data, and calibrating the obtained glucose monitor data using the calibration characteristics. In additional embodiments, calculation of the calibration characteristics includes linear regression and, in particular embodiments, least squares linear regression. Alternatively, calculation of the calibration characteristics includes non-linear regression. Data integrity may be verified and the data may be filtered. Further, calibration techniques may be modified during a fast rate of change in the patient's blood glucose level to increase sensor accuracy. | 04-30-2009 |
20090112479 | PATHWAY DISPLAY METHOD, INFORMATION PROCESSING DEVICE, AND PATHWAY DISPLAY PROGRAM PRODUCT - A pathway display method in an information processing device processing information includes a pathway information acquiring step (S | 04-30-2009 |
20090112480 | METHOD AND APPARATUS FOR CLUSTERING GENE EXPRESSION PROFILES BY USING GENE ONTOLOGY - Provided are a method and apparatus for clustering gene expression profiles by using the Gene Ontology (GO). The method includes: selecting one or more GO terms from a GO tree; receiving gene expression data sets; classifying the gene expression data sets into groups according to the GO terms; firstly clustering gene expression data belonging to each of the groups based on a similarity of the gene expression data; and secondly clustering the gene expression data sets by using the result of the first clustering as a seed. | 04-30-2009 |
20090112481 | HIGH-RESOLUTION MELTING ANALYSIS - The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. In one aspect, methods and systems are disclosed for resolving a denaturation curve of a sample containing a first and second nucleic acid into a resolved denaturation curve for the first nucleic acid and a resolved denuration curve for the second nucleic acid. | 04-30-2009 |
20090112482 | MICROARRAY DETECTOR AND SYNTHESIZER - The present invention relates to novel systems, devices, and methods comprising spatial light modulators for use in the reading and synthesis of microarrays. For example, the present invention provides micromirror systems for synthesizing and acquiring data from nucleic acid microarrays and systems for collecting, processing, and analyzing data obtained from a microarray. | 04-30-2009 |
20090112483 | Protocol For Risk Stratification of Ischemic Events and Optimized Individulaized Treatment - A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit preparation of an individualized assessment of ischemic event risk and individualized treatment of a subject. | 04-30-2009 |
20090119019 | Small Molecule Mimetics of Erythropoietin - The invention features computer-assisted methods for identifying molecules which will bind to the EPO receptor and act as an erythropoietin (EPO) mimetic. Preferred EPO mimetics identified using the method of the invention act as agonists of the EPO receptor in one or more in vitro or in vivo biological assays of EPO activity. | 05-07-2009 |
20090119020 | PCR ELBOW DETERMINATION USING QUADRATIC TEST FOR CURVATURE ANALYSIS OF A DOUBLE SIGMOID - Systems and methods for determining whether the data for a growth curve represents or exhibits valid or significant growth. A data set representing a sigmoid or growth-type curve, such as a PCR curve, is processed to determine whether the data exhibits significant or valid growth. A first or a second degree polynomial curve that fits the data is determined, and a statistical significance value for the curve fit is determined. If the significance value exceeds a significance threshold, the data is considered to not represent significant or valid growth. If the data does not represent significant or valid growth, the data set may be discarded. If the significance value does not exceed the significance threshold, the data is considered to represent significant or valid growth. If the data set is determined to represent valid growth, the data is further processed to determine a transition value in the sigmoid or growth curve, such as the end of the baseline region or the elbow value or Ct value of a PCR amplification curve. | 05-07-2009 |
20090119021 | METHOD AND APPARATUS FOR DETERMINING AND DISPLAYING MEDICAL INFORMATIONS - The invention relates to a method for determining and displaying medical informations, in which rough measurement data collected with the aid of different medical measuring methods in at least one measurement interval on the same test subject are stored and in which evaluation data are extracted from the rough measurement data. Further for generating medical informations for at least two selected measuring methods from among the different medical methods, the evaluation data extracted from the in each case associated rough measurement data of a measurement interval are interlinked and for the at least one measurement interval the linked evaluation data are processed as medical informations for outputting on a graphic output device. The invention also relates to an apparatus for performing this method. | 05-07-2009 |
20090125241 | REAL TIME WATER ANALYSIS SYSTEM FOR METALS, CHEMICALS, RADIOLOGICAL AND BIOLOGICAL MATERIALS (CBRNME) WITHIN WATER - A method and water analysis system are provided to automatically, and without manual intervention, detect and identify contamination and/or hazardous material within one or more water samples from a potable and/or effluent water system. The method includes collecting a water sample from a potable and/or effluent water system; monitoring, in response to the collecting, sensors-detectors that are located in proximity to the collected water sample and receiving sensor-detector data from the sensors-detectors. The sensors-detectors include: laser induced breakdown spectrometry (LIBS) sensor technology, gas chromatography sensor technology, mass spectroscopy sensor technology, calorimetric spectroscopy sensor technology, and radiation detection technology. The method further includes spectrally analyzing, in response to the monitoring, the received sensor-detector data to detect, identify, and quantify, metals, chemicals, radiological materials, and biological materials, within the collected water sample. | 05-14-2009 |
20090125242 | Tomographic phase microscopy - The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering. | 05-14-2009 |
20090125243 | Apparatus and method for identifying the original femorotibial joint location in a revision knee replacement - An apparatus and method is disclosed of identifying the original femorotibial joint location in a revision knee replacement of a patient. The invention comprises selecting a first reference point (H) relative to the femoral head of the patient. A second reference point (A) is selected relative to the adductor tubical of the femur of the patient. The femorotibial joint location (J) is calculated through a relationship between the first reference point (H) and the second reference point (A) of the patient. The method and apparatus defines a femur reference plane to assist in establishing the correct rotation of the femur in a revision knee replacement of a patient. | 05-14-2009 |
20090132171 | Screening Method for Specific Protein in Proteome Comprehensive Analysis - A screening method for a specific protein in a proteome analysis comprises: (a) obtaining samples containing a protein or protein digest from a cell or tissue in a specific group and a control group; (b) analyzing the samples obtained in the step (a) with a mass spectrometer, thereby obtaining mass spectrometry data; (c) analyzing the mass spectrometry data obtained in the step (b) using an arbitrary database searching software, thereby acquiring a protein list containing items for specifying proteins and indexes for identifying the proteins, for each of the samples; (d) averaging values of the indexes for each of the items in all of the protein lists acquired in the step (c), and acquiring protein list models of the specific group and the control group, containing the average values of the indexes; (e) calculating a difference between the average values for each of the items, between the protein list models of the specific group and the control group obtained in the step (d), and acquiring one protein list in which the items are rearranged in the order of the difference between the average values; and (f) selecting a protein with a large difference between the average values, from the protein list acquired in the step (e). | 05-21-2009 |
20090132172 | METHODS FOR DETECTING AND DIAGNOSING LOW BONE MASS DENSITY - The invention encompasses methods of detecting and diagnosing low bone mass density. The method comprises, in part, obtaining nucleic acid expression data from a plurality of nucleic acid sequences, wherein at least one nucleic acid sequence is selected from the group consisting of ESR1, MAPK3, MECP2, PSTPIP1, SLA, STKL1, WNK1, and ZNF446. | 05-21-2009 |
20090132173 | COMPUTING LIKELIHOOD RATIOS USING PEAK HEIGHTS - Methods for comparing a first DNA profile with a second DNA profile are provided. The likelihood ratio for one hypothesis relative to another, as to the sources of the DNA, is conditioned on quantity of DNA in the test sample providing the first DNA profile and/or another sample providing the second DNA profile. | 05-21-2009 |
20090132174 | SEAFOOD PHYSICAL CHARACTERISTIC ESTIMATION SYSTEM AND METHOD - Systems and methods for estimating a physical characteristic of a seafood product are provided. In one system, the estimate is based on a slope defined by a ratio of changes in peak resonant amplitude and frequency of an electromagnetic resonant circuit in loaded and unloaded states. In another system, a first probe of a plurality of probes is driven with a test signal when the plurality of probes is loaded by a seafood product and the estimate is based on received test signals at one or more of the other probes. In another system, the estimate is based on the loading effect of a seafood product on an electromagnetic resonant circuit, which is also used to read an ID from an RFID associated with the seafood product. The systems and methods may be used for individual specimens, or to determine an average estimate for multiple specimens at one time. | 05-21-2009 |
20090138203 | SYSTEMS AND METHODS FOR USING MOLECULAR NETWORKS IN GENETIC LINKAGE ANALYSIS OF COMPLEX TRAITS - The present disclosed subject matter relates to methods of using molecular networks in whole genome genetic linkage analysis of complex inherited disorders, including determining gene-specific linkage probability values for one or more genes represented in a predetermined molecular interaction network. The present disclosed subject matter further relates to methods of identifying one or more gene that is associated with one or more heritable diseases, and methods of diagnosing the heritable diseases. | 05-28-2009 |
20090138204 | Single nucleotide polymorphisms sensitively predicting adverse drug reactions (ADR) and drug efficacy - Provided are diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Also provided are polymorphic sequences and other genes and isolated polynucleotides encoding a phenotype associated (PA) gene polypeptide useful in methods to identify therapeutic agents and useful for preparation of a medicament to treat cardiovascular disease or influence drug response. | 05-28-2009 |
20090138205 | OPTIMIZED METHOD FOR LID BIOSENSOR RESONANCE DETECTION - An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor. | 05-28-2009 |
20090138206 | SYSTEM OF ANALYZING PROTEIN MODIFICATION WITH ITS BAND POSITION OF ONE-DIMENSIONAL GEL BY THE MASS SPECTRAL DATA ANALYSIS AND THE METHOD OF ANALYZING PROTEIN MODIFICATION USING THEREOF - The present invention relates to a method of analyzing protein modification. The method of invention for analyzing protein distribution and characteristics on one-dimensional gel provides the way to analyze proteins of samples on one-dimensional gel quantitatively and provides information on interactions among proteins and further can be effectively used for the development of a novel diagnostic and therapeutic method for a disease by screening a disease marker protein. | 05-28-2009 |
20090138207 | GLUCOSE METER SYSTEM AND MONITOR - A handheld portable glucose meter, includes a glucose sensor having a sensor output related to glucose in a blood sample on a blood glucose test strip. A display is configured to display information to a user. The handheld portable glucose meter maintains information related to a depletion of a supply of materials. The handheld portable glucose meter is configured to communicate with a remote location and to send data to the remote location to reorder the supply. | 05-28-2009 |
20090138208 | IMMUNOGLOBULIN G BINDING POCKET - The present invention relates to a human IgG binding pocket comprised of a first interacting surface, which originates from an IgG κ light chain, and a second interacting surface, which originates from an IgG heavy chain, which amino acids are strictly conserved between human IgGs of κ-type. The invention also embraces an isolated and purified polypeptide, which comprises said binding pocket. Further, the invention relates to various methods of using the novel binding pocket, such as in screening for identification of chemical entities capable of selective binding thereof, and in other experimental and/or virtual methods for design and/or identification of chemical entities capable of selective binding thereof. | 05-28-2009 |
20090143993 | Method of Diagnosing the Presence and/or Severity of a Hepatic Pathology in an Individual and/or of Monitoring the Effectiveness of a Treatment for one such Pathology - The invention relates to a method of diagnosing the presence and/or severity of a hepatic pathology and/or of monitoring the effectiveness of a curative treatment against a hepatic pathology in an individual, comprising the establishment of at least one non-invasive diagnostic score, in particular a diagnostic score for portal and septal fibrosis and/or an estimate score for the fibrosis area and/or an estimate score for the fractal dimension. | 06-04-2009 |
20090143994 | Managing Body Composition - Among other things, at least two different independent providers of body composition management services are enabled to have online access through respective graphical user interfaces to body composition information and plans that are associated with respective clients of the providers and that are stored on the server. The graphical user interfaces are different for different independent providers. At least some of the information and plans associated with the clients of the different independent providers are stored in a common format in a common database maintained by the server. | 06-04-2009 |
20090143995 | System and Method for Management and Evaluation of Genotyping Data - Provided are systems and methods for improving efficiency in high throughput genotyping operations by implementing a unique workflow management architecture that permits faster and more accurate determination and evaluation of genotyping and haplotyping, and software to accomplish the same. The system provides a user with a highly-accurate summary and multiple-field breakdown of panels of genotyping data samples for batch approval and batch selection of ambiguous or potentially unique sample sets which can be selected for further analysis. Also provided are tools for evaluating and improving the operation of a genotyping laboratory to maximize the testing and typing of the significant quantities of raw data used in genotyping that are produced in high-throughput laboratory environments. | 06-04-2009 |
20090143996 | AIRWAY SENSOR - An airway sensor includes a gas analyzing apparatus for analyzing at least one respiratory gas and a connecting unit for communication with a remotely located host device. The gas analyzing apparatus connected to a sensor electronics and which sensor electronics is also common for flow measuring device for measuring respiratory gas flow and pressure measuring device for measuring respiratory airway pressure when connected to said sensor electronics. | 06-04-2009 |
20090150080 | METHODS OF GENETIC ANALYSIS INVOLVING THE AMPLIFICATION OF COMPLEMENTARY DUPLICONS - The invention relates to methods for genetic analysis of DNA sequences containing complementary duplicons which are duplicated and linked DNA sequences separated by an intermediate sequence. Furthermore, the invention relates to the Bidirectional Amplification of Complementary Duplicons (BACD) using a single primer. The amplification of complementary duplicons can be used for a variety of purposes such as, but not limited to, determining the species from which a sample comprising genomic DNA is derived, or used as a marker for a trait of interest. Also provided are means for analysing large datasets which can be used to identify primers useful for the genetic analysis methods of the invention. | 06-11-2009 |
20090150081 | Automatic analyzer for enzyme immunoassays - An automatic analyzer for enzyme immunoassays, of the type that comprises a serum dispensing assembly, a reagent dispensing assembly, an incubation assembly, a washing assembly, a reader assembly and a data processing and storage assembly. The analyzer comprises a unit for containing at least one well for performing analyses on a serum and at least one test-tube which contains a respective reagent; the unit is accommodated detachably within a respective internal frame of the analyzer. The reagent dispensing assembly, the incubation assembly, the washing assembly and the reader assembly can move from a first configuration of maximum distance from the unit accommodated in the frame to a second configuration of substantial overlap with at least one portion of the unit. | 06-11-2009 |
20090150082 | Method and system for realizing collaboration between bio-signal measurement devices - The present invention relates to technology for realizing collaboration between bio-signal measurement devices used for personal health care. In a method of realizing collaboration between bio-signal measurement devices, connection to a plurality of bio-signal measurement devices for measuring bio-signals from a user is made, and a plurality of pieces of bio-signal data is received from the bio-signal measurement devices. First features are calculated from respective pieces of bio-signal data. Data required for calculation of second features is selectively received from the calculated first features, second features are calculated. The calculated first and second features are normalized, and the normalized first and second features are transmitted to at least one application program. | 06-11-2009 |
20090150083 | ANALYZER, ANALYSIS METHOD AND COMPUTER PROGRAM PRODUCT - An analyzer includes a determining unit that determines whether an analysis result of a sample corresponding to a controlled specimen having a known value is normal or not based on an analysis result of the controlled specimen. The analyzer also includes a generating unit that generates analysis information in which a determination result by the determining unit is associated with each analysis result of samples; and an output unit that outputs the analysis information generated by the generating unit. | 06-11-2009 |
20090157323 | Methods and systems for specifying an avatar - Avatars, methods, apparatuses, computer program products, devices and systems are described that carry out presenting at least one characteristic to at least one member of a population cohort; measuring at least one physiologic activity of the at least one member of the population cohort, the at least one physiologic activity proximate to the at least one presented characteristic; associating the at least one physiological activity with at least one mental state; and specifying at least one avatar attribute based on the at least one mental state. | 06-18-2009 |
20090157324 | Method for Analyzing Gene Expression Data - The invention provides a method for selecting one or more genes from among a predetermined group of genes whose expression level is significantly different among a first group of individuals in a population in comparison with a second group within the population. The first group of individuals may be, for example, a group of individuals suffering from an illness that responded to a predetermined treatment. The second group of individuals may be a group of individuals suffering from the same illness that did not respond to the treatment. In accordance with the method of the invention, for each of one or more selections of m individuals from the first subset and n individuals from the second subset, the statistical significance of each gene i in the up group of the genes, and in the down group of genes are determined, where the up group is a group of genes for which the expression level in the first group is greater than an expression level in the second group and the down group is a group of genes for which the expression level in the first group is less than an expression level in the second group. The genes in the up and the down groups are ranked according to the number of times each gene received the highest statistical significance among the one or more selections of individuals. A subset of genes in the up group having the highest rankings and a subset of genes in the down group having the highest rankings are then selected. | 06-18-2009 |
20090157325 | BIOSIGNAL MEASURING APPARATUS - A biological signal measuring apparatus includes a first biological signal measuring sensor attached to an earphone used for a mobile phone; and a biological signal receiver for receiving a biological signal from the first biological signal measuring sensor to thereby generate first raw data. The apparatus may further include a second biological signal measuring sensor attached to one of the mobile phone and an adaptor connected to the mobile phone, wherein the biological signal receiver receives a biological signal from the second biological signal measuring sensor to thereby generate second raw data. The apparatus is provided with a controller for detecting whether the mobile phone is used, wherein the controller drives the first and the second biological signal measuring sensor to measure the biological signal when the mobile phone is being used, and stops measuring the biological signals when the use of the mobile phone is finished. | 06-18-2009 |
20090157326 | Diagnosis and prognosis of breast cancer patients - The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein. | 06-18-2009 |
20090157327 | Electronic Device, Arrangement, and Method of Estimating Fluid Loss - There is provided an electronic device comprising: a processing unit configured to receive skin temperature data generated by a measuring unit, to receive performance data from a measuring unit, and to determine a theoretical fluid loss value on the basis of the received performance data. The electronic device further comprises: a processing unit configured to determine a relation between a predetermined perspiration threshold and a skin temperature value deduced from the received skin temperature data; and to determine a real fluid loss value on the basis of the theoretical fluid loss value and the determined relation between the predetermined perspiration threshold and the skin temperature value. | 06-18-2009 |
20090157328 | METHOD OF DETERMING EXCRETION OF SODIUM AND OTHER ANALYTES - Methods and kits of the invention are useful for calculating 24-hour excretion of sodium without the need to collect urine for 24 hours. | 06-18-2009 |
20090171589 | Method, System and Computer Program Product for Evaluation of Blood Glucose Variability In Diabetes From Self-Monitoring Data - A system, computer program product, method and algorithm for evaluation of blood glucose variability—one of the most important parameters of diabetes management. An embodiment of the method may use routine self-monitoring blood glucose (SMBG) data collected over a period of 2-6 weeks, for example, based on a theory of risk analysis of blood glucose data. One aspect may include a method, system and computer program product for computing the Average Daily Risk Range (ADRR)—a measure of overall glucose variability. Another aspect may include a method, system, and computer program product for estimating separately the glucose variability in the hypoglycemic range via a Low BG Index (LBGI) and the glucose variability in the high BG range via High BG Index (HBGI) followed by a combination of the two indices into a single variability display. | 07-02-2009 |
20090171590 | System and Methods for Sample Analysis - The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention. | 07-02-2009 |
20090171591 | Methods for classification of somatic embryos comprising hyperspectral line imaging - The present invention relates to methods, apparatus, and imaging systems for using near-infrared spectroscopy imaging of plant embryos for classifying plant embryos. In one embodiment, a method is provided for classifying a plant embryo of an unknown type based on near infrared spectroscopy imaging. | 07-02-2009 |
20090171592 | Homology Models of Mammalian Zinc Transporters and Methods of Using Same - The present invention is a method of identifying a compound that has a sufficient level of binding with a target site on a mammalian zinc transporter, or a portion thereof. The method comprises (a) providing a homology model of a mammalian zinc transporter, or portion thereof, comprising at least one target site; and (b) employing computational means to evaluate the level of binding of the compound with the target site, or a portion thereof. If a sufficient level of binding is found, then a compound is identified. | 07-02-2009 |
20090177405 | METHOD, A COMPUTER PROGRAM AND A COMPUTER SYSTEM FOR DETERMINATION WHETHER A SUBJECT HAS AN INCREASED RISK FOR ACQUIRING A DISEASE - A method, a computer program and a computer system are described for determining whether a subject has an increased risk for acquiring a disease, said method comprising selecting at least one disease, for example using a user interface wherein in a field | 07-09-2009 |
20090177406 | Slope-Based Compensation - A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals with one or more index functions extracted from the output signals. The index functions determine at least one slope deviation value, ΔS, or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias. | 07-09-2009 |
20090177407 | METHOD AND DEVICE FOR ANALYSIS, VERIFICATION AND QUALITY ASSURANCE OF DRUGS FOR INJECTION OR INFUSION - The present invention relates to a method and device for non-invasive analysis of the identity and concentration of drugs that are to be administered by injection or infusion. | 07-09-2009 |
20090177408 | METHODS AND SYSTEMS FOR HIGH CONFIDENCE UTILIZATION OF DATASETS - Methods and systems for high-confidence utilization of datasets are disclosed. In one embodiment, the method includes selecting a metric for determining substantially optimal combination of true positives and false positives in a data set, applying an optimization technique, and obtaining, from the results of the optimization technique, a value for at least one optimization parameter, the value for at least one optimization parameter resulting in substantially optimal combination of true positives and false positives. A number of true positives and a number of false positives are a function of the one or more optimization parameters. | 07-09-2009 |
20090187348 | Sample processing apparatus, method of outputting processing result by sample processing apparatus, and computer program product - Disclosed is a sample processing apparatus, comprising: a sample processing unit for processing a sample with an auxiliary item used to process the sample; an output device for outputting a processing result by the sample processing unit; and a controller for determining whether or not the auxiliary item is appropriate for the sample processing by sample processing unit, and controlling, when determining that the auxiliary item is not appropriate for the sample processing by the sample processing unit, the output device so as to output the processing result and reliability information showing that the processing result has a low reliability. Also disclosed is a method for outputting the processing result by the sample processing apparatus and a computer program product. | 07-23-2009 |
20090187349 | Consumption Monitoring Device - Described is a consumption monitoring device for monitoring the amount of consumables consumed by an animal during a monitoring period. More specifically, the consumption monitoring device measures the weight of the consumables, which are contained within a receptacle, and detects any change in the weight, such as when additional consumables are placed within the receptacle or when the animal consumes all or some of the consumables. The device calculates various values based on these changes in weight, at least one of which indicates the amount of consumables consumed by the animal. The device displays this calculated value such that the user is informed of the amount of consumables consumed by the animal within the monitoring period. This information assists the user in maintaining the animal on a desired feeding program. | 07-23-2009 |
20090187350 | BIOSENSING APPARATUS AND SYSTEM - A bio-sensing system comprises a light source, a bio-sensing apparatus, a detecting platform, and a processing unit. A bio-sensing apparatus further comprising a substrate, a sample with at least one analyte, at least one grating bound on the substrate for diffracting a light beam in a reflection mode and outputting at least one output light beam, a plurality of nanoparticles being bound on one side of the grating, a molecular recognition unit bound on said nanoparticle surface, and a cover plate covering the nanoparticle-modified side of the substrate. The detecting platform receives a signal while the at least one output light beam passing through the bio-sensing apparatus. The processing unit couples with the detecting platform for receiving and analyzing the signal. Wherein when the analyte passes through the microfludic channel to contact with said nanoparticles, the at least one output light beam changes in accordance with the refractive index of the sample or in accordance with the interaction of the analyte with said molecular recognition unit bound on said nanoparticle surface. | 07-23-2009 |
20090187351 | ANALYTE TESTING METHOD AND SYSTEM - Described and illustrated herein is an exemplary method of operating an analyte measurement device having a display, user interface, processor, memory, and user interface buttons. Such method can be achieved by measuring an analyte with the analyte measurement device, displaying a value representative of the analyte, prompting a user to select a flag to associate the flag with the value, and pressing only one of the user interface buttons once to store the flag with the value in the memory of the analyte measurement device. In one embodiment, the testing device is a glucose meter and the analyte being tested is glucose. | 07-23-2009 |
20090192719 | Exploratory visualization of protein complexes by molecular weight - Methods, user interfaces, systems and computer readable media for visualizing data to facilitate analysis of the data. Mass data values are provided for a sample having been separated into portions according to a first characteristic of the sample, the slices having been processed to provide the mass data values of members of the sample occurring in the portions. A plot of the mass data values is displayed on a first axis versus the portions on a second axis of the plot. A mass data value of a member may be selected on the plot, and all mass data values occurring in the portion in which the selected mass data value is located are displayed using first visual indicators that are visibly distinct from visual indicators used to display data values occurring outside of the portion in which the selected data value is located. | 07-30-2009 |
20090192720 | METHODS AND COMPOSITIONS FOR DETERMINING ENZYMATIC ACTIVITY AND SPECIFICITY OF METHYLTRANSFERASES - The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the activity or substrate specificity of putative O-methyl-transferases, methods of identifying potential substrates of O-methyltransferases, and methods of identifying potential inhibitors of methyltransferases. | 07-30-2009 |
20090192721 | METABOLIC PHENOTYPING - A method of generating models with which to characterise selected aspects of the metabolic phenotype of subjects without dosing a test substance to those subjects or with which to predict, without dosing, the post-dose responses of subjects where those responses are dependent on metabolic phenotype, the method comprising: obtaining pre-dose data relating to a plurality of subjects before dosing with a dosing substance; obtaining post-dose data relating to the plurality of subjects after dosing with the dosing substance; and correlating inter-subject variation in the pre-dose data with inter-subject variation in the post-dose data, and generating a pre-to-post-dose predictive model on the basis of the observed correlation. The models may be used to determine selected aspects of the metabolic phenotype of a subject or to predict, without dosing, the post-dose responses of subjects. This is achieved by analysing data relating to the un-dosed subject in relation to a model describing the correlation of pre-dose and post-dose data relating to a plurality of subjects when dosed with a particular substance which challenges the biochemical transformation or pathway of interest; and generating, according to the predetermined criteria of the model, a numerical measure or classification describing the metabolic phenotype of the un-dosed subject. | 07-30-2009 |
20090192722 | SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA - Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided. | 07-30-2009 |
20090192723 | Dosimeter for vibrations - The present invention relates to an arrangement for calculation and presentation of transferred vibration dose from a handheld machine to the hand of a user, wherein a sensor unit | 07-30-2009 |
20090192724 | TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. | 07-30-2009 |
20090198449 | Dual-Slot Biological Test Meter Test Procedure - A dual-slot biological test meter test procedure includes the steps of a) inserting a code card into a first test slot of a dual-slot biological test meter, b) inserting a test strip into a second test slot of the dual-slot biological test meter to initiate the dual-slot biological test meter; c) inputting predetermined parameters into the dual-slot biological test meter, d) judging if the result is over the threshold or not after application of the blood sample to the reaction zone of the inserted test strip, and then entering a first stage to electrically connect the two electrodes of the inserted test strip if the result is over the threshold, and then entering a second stage to output a voltage to the electrodes of the inserted test strip for a predetermined length of time set by the code card, e) entering a third stage to read the current value subject to the setting of the code card when the predetermined length of time is up, then f) calculating the test result through a computing method set by the code card subject to the current value obtained; and then g) showing the test result on a display. | 08-06-2009 |
20090198450 | Integrated Biosensor and Simulation System for Diagnosis and Therapy - BioMEMS/NEMS appliance biologically monitors an individual, using biosensors to detect cellular components. Data is simulated or analyzed using systems-biology software, which provides diagnostic or therapeutic guidance. | 08-06-2009 |
20090198451 | Integrated Biosensor and Simulation System for Diagnosis and Therapy - BioMEMS/NEMS appliance biologically monitors an individual, using biosensors to detect cellular components. Data is simulated or analyzed using systems-biology software, which provides diagnostic or therapeutic guidance. | 08-06-2009 |
20090204333 | METHODS FOR USING CO-REGULATED GENESETS TO ENHANCE DETECTION AND CLASSIFICATION OF GENE EXPRESSION PATTERNS - The present invention provides methods for enhanced detection of biological response patterns. In one embodiment of the invention, genes are grouped into basis genesets according to the co-regulation of their expression. Expression of individual genes within a geneset is indicated with a single gene expression value for the geneset by a projection process. The expression values of genesets, rather than the expression of individual genes, are then used as the basis for comparison and detection of biological response with greatly enhanced sensitivity. In another embodiment of the invention, biological responses are grouped according to the similarity of their biological profile. | 08-13-2009 |
20090204334 | LUNG CANCER BIOMARKERS - Disclosed are protein biomarkers and their use in diagnosing lung cancer or to make a negative diagnosis in patients. Also disclosed are kits for the diagnosis of lung cancer that detect the protein biomarkers of the invention, as well as methods using a plurality of classifiers to make a probable diagnosis of lung cancer. In certain aspects of the invention, the methods include use of a decision tree analysis. Various computer readable media and their use according to the invention are also disclosed. | 08-13-2009 |
20090204335 | Method for acquiring and managing morphological data of persons on a computer network and device for carrying out said method - The invention relates to a method for acquiring and managing morphological data of persons on a computer network, wherein said data is used for producing and/or delivering ready-made individually dimensioned clothes by at least one of the plurality of manufacturers. The inventive method consists, at a preliminary stage, in forming a first data base ( | 08-13-2009 |
20090204336 | PDZ-Domain Modulators - The invention relates to compounds which bind to the PDZ domains of proteins with PDZ domains, the uses of such compounds and screening methods for identification of such compounds. | 08-13-2009 |
20090204337 | Method for Identifying the Elution Time of an Analyte - A method for determining a time of elution of a peptide of interest from a liquid chromatography column includes a step of obtaining chromatographic data for each of a plurality of candidate fragment ions of the peptide of interest. A time along a common chromatographic time is scale determined corresponding to maximum overlay of the ion signals measured for each of the plurality of candidate fragment ions. Finally, the determined time is assigned as the time of elution of the peptide of interest from the liquid chromatography column. In particular, the chromatographic data is acquired during selective reaction monitoring of an eluate from the liquid chromatography column containing the peptide of interest. The chromatographic data includes ion signals measured along the common chromatographic time scale for each of the plurality of candidate fragment ions. | 08-13-2009 |
20090204338 | Method of deriving a quantitative measure of the instability of calcific deposits of a blood vessel - A computer-implemented method of processing an image of at least part of a blood vessel to derive a measure indicative of the instability of calcific deposits in the blood vessel, said blood vessel containing at least one calcific deposit, comprises locating and annotating one or more calcific deposits. Using information derived from the annotation of said calcific deposits, the method further comprises calculating a measure reflecting either one or both of a) the aggregate of the deviations from roundness of individual calcific deposits, and b) up to at least a threshold value, the extent to which the separate calcific deposits are spaced from one another. | 08-13-2009 |
20090204339 | Apparatus, method and computer program product for determining confidence measures and combined confidence measures for assessing the quality of proteomic and genomic data - An apparatus, method, and computer program product are provided for determining a confidence measure for the output of a process for assessing proteomic and genomic information samples. Typically, data is received as the results from a microarryi experiment. The confidence measure is intended to determine whether the results of the experiment have been degraded due to experimental error. Several criteria are used by which quality is determined. The criteria are preferably combined into a combined quality measure in order to account for several possible sources of error. | 08-13-2009 |
20090204340 | Method Of Calibrating An Analyte-Measurement Device, And Associated Methods, Devices And Systems - The invention relates to a method for calibrating an analyte-measurement device that is used to evaluate a concentration of analyte in bodily fluid at or from a measurement site in a body. The method involves measuring a concentration, or calibration concentration, of an analyte in blood from an “off-finger” calibration site, and calibrating the analyte-measurement device based on that calibration concentration. The invention also relates to a device, system, or kit for measuring a concentration of an analyte in a body, which employs a calibration device for adjusting analyte concentration measured in bodily fluid based on an analyte concentration measured in blood from an “off-finger” calibration site. | 08-13-2009 |
20090204341 | SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR - Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk. | 08-13-2009 |
20090210162 | METHOD AND APPARATUS FOR ESTIMATING A PAO2 VALUE FOR A PATIENT SUBJECT TO EXTRACORPOREAL CIRCULATION - The invention relates to a method and an apparatus for estimating a P | 08-20-2009 |
20090210163 | System And Method For Evaluating Physiological Parameter Data - Embodiments disclosed herein may include systems and methods for evaluating physiological parameter data. Embodiments of methods may include monitoring a patient to produce a signal comprising a sequence of numerical values for a physiological parameter over a time period, calculating an index from the signal, comparing the index to a reported index, and if the index is greater than the reported index, setting the reported index to the value of the index. Embodiments of methods may include calculating a modulation of the signal, comparing the modulation to a previous value of the modulation to identify a trend in the modulation and if the trend corresponds to an undesirable condition, using a first function to increase the reported index. Embodiments of methods may include providing an indication of a physiological status based on the reported index. | 08-20-2009 |
20090210164 | ANALYTE MONITORING DEVICE AND METHODS OF USE - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor. | 08-20-2009 |
20090216457 | METHOD FOR IMPROVING FLUORESCENCE IMAGE CONTRAST - There is provided an improved method for enhancing fluorescence images of an object, such as a biological tissue, by selectively eliminating or reducing unwanted fluorescence from fluorophores other than the fluorophore of interest. The method is based on the measurement of the lifetime of fluorophores while preserving information related to the fluorescence intensity of the fluorophore of interest. | 08-27-2009 |
20090216458 | Biological-Information Processing Apparatus, Biological-Information Processing Method, Biological-Information Processing Program and Program Recording Medium - The present invention relates to a biological-information processing apparatus and a method, which are capable of measuring a hybridisation of a DMA chip without making use of a complex measurement configuration, at a low cost and with a high degree of accuracy, as well as relates to a program and a recording medium. An area enclosed by a spot boundary | 08-27-2009 |
20090216459 | Ultrasonic System for Grading Meat Tenderness - Meat tenderness is determined by analyzing backscattered ultrasound signals. A signal envelope function computed from the backscattered ultrasound signals is used to derive a number of different parameters, which comprise a unimodal decay factor, a bimodal decay factor, a quiescence time, an event frequency parameter, and an event asymmetry index. Two or more of these factors are combined using a decision algorithm, which can be a neural network, a fuzzy logic classifier, a Bayesian classifier, a regression, an instance-based classifier, a decision tree, or a learned rule. These methods can also be applied to determine characteristics of the physiology of a live organism. | 08-27-2009 |
20090216460 | METHOD TO DETERMINE THE DEGREE AND STABILITY OF BLOOD GLUCOSE CONTROL IN PATIENTS WITH DIABETES MELLITUS VIA CREATION AND CONTINUOUS UPDATING OF NEW STATISTICAL INDICATORS - Systems and methods for determining a stability of a blood glucose concentration of a patient are provided. The system comprises a processor that may be programmed to receive blood glucose concentration test results each taken from the patient at a different time over a time period and to compute a time-averaged glucose parameter indicative of blood glucose concentration control over the time period. In addition, the processor may be programmed to compute a virtual blood hemoglobin parameter through a simulated measurement of a blood hemoglobin, the virtual blood hemoglobin parameter being indicative of blood glucose concentration control over an extended time period encompassing the time period. Further, the processor may be programmed to compute a lability factor parameter indicative of a variability in blood glucose concentration over the time period. | 08-27-2009 |
20090222212 | ANALYSIS OF MIXED SOURCE DNA PROFILES - A method of analysing DNA samples from mixed sources includes i) obtaining an observed result relating to a value set for a characteristic of the DNA; ii) randomly selecting a selected value set for that DNA characteristic and generating an expected result from that selected value set; iii) comparing the observed result and the expected result and quantifying the difference there between. The method also includes iv) considering the selected value set to be the optimal match; v) randomly selecting a different selected value set and generating another expected result from that selected value set; vi) comparing the observed result with the another expected result and quantifying the difference there between; vii) replacing the existing optimal value set with the different selected value set of step v) if a criteria is met. The method further includes viii) repeating steps v), vi) and vii) at least 10 times; ix) the last optimal match being taken to be the optimal match for the value set for the DNA. | 09-03-2009 |
20090222213 | AUTOMATIC ANALYZER - The present invention provides an index that makes it possible to use, in an automatic analyzer, an approximate expression based on a theoretical chemical reaction formula derived from reaction process data, and automatically check for apparatus abnormalities, reagent deteriorations, and improper accuracy control during each continuous or individual inspection. | 09-03-2009 |
20090222214 | METHOD AND APPARATUS FOR MEASURING NON-NUTRITIVE SUCK PATTERN STABILITY - Method and apparatus are provided for generating an index associated with non-nutritive suck pattern stability. A method includes measuring a plurality of non-nutritive suck (NNS) pressure samples, generating a plurality of correlation values using the NNS pressure samples, and generating a measure of non-nutritive suck pattern stability using the plurality of correlation values. | 09-03-2009 |
20090222215 | Integrated Biosensor and Simulation System for Diagnosis and Therapy - BioMEMS/NEMS appliance biologically monitors an individual, using biosensors to detect cellular components. Data is simulated or analyzed using systems-biology software, which provides diagnostic or therapeutic guidance. | 09-03-2009 |
20090240439 | Predicting responses to drugs or drug cadidates - Patients can be segregated into groups expected to have differential responses to drug treatment based on test results. Patient sub-populations expected to benefit from a particular treatment can thus be identified and directed to that treatment. Similarly, sub-populations expected to suffer a greater risk of side effects from a particular treatment can be identified and steered to other, safer treatments. A patient under treatment can be monitored for safety. | 09-24-2009 |
20090240440 | Non-Invasive Glucose Monitoring - A monitoring system for monitoring the glucose level of a subject having a glucose level history is disclosed. The system comprises (a) a non-invasive measuring device, operable to measure and record an electrical quantity from a section of the subject body, so as to provide a time-dependence of the electrical quantity over a predetermined time-period. The system further comprises (b) a processing unit, communicating with the non-invasive measuring device. The processing unit comprises: an extractor, for extracting a plurality of parameters characterizing the time-dependence, a correlation function calculator for calculate a subject-specific correlation function, and an output unit, communicating with the correlation function calculator and configured to output the glucose level of the subject. The subject-specific correlation function describes the glucose level history and is defined over a plurality of variables, each corresponding to a different parameter. | 09-24-2009 |
20090248314 | Network-based system and method for diagnostic pathology - An optimized network-based system and method for providing reagents or reagent-like matter for the differential diagnosis of medical conditions using a hosted software program coupled with a comprehensive medical reference database. Suspected diagnoses of medical conditions are entered into the system by a user. Using meta-analysis, the system generates a list of potential reagents and numerical measures of each reagent's behavior for each differential for use in further testing. The results of the testing are compared by the user against numerical measures of each reagent's behavior and corresponding stored digital images in the network-based system. The user then selects among those diagnoses in the system whose images and corresponding numerical measures of each reagent's behavior are most comparable with the results of the testing. The system then generates a diagnosis, diagnoses, or inconclusive results in order to reach an ultimate diagnosis. | 10-01-2009 |
20090248315 | System and Method for Determining Clinical Equivalence of Test Methods - A system, method and computer readable medium of instructions are provided which are useful for determining whether an evaluation testing method or device is clinically equivalent to a reference testing method or device. The report can include a modified mean difference plot, a variability chart, confidence intervals for bias and a plot of the intervals. A graphical user interface is provided to allow data associated with the reference and evaluation methods or devices to be identified. A level of variance in the reference method is determined. An observed bias between the evaluation methods or devices and the reference methods or devices is calculated. A confidence interval for the bias is calculated. The biases between the evaluation methods or devices and reference method or device is compared relative to the level of variance in the reference method, and a report is generated including a conclusion about whether the evaluation methods or devices are clinically equivalent to the reference method or device. | 10-01-2009 |
20090248316 | METHOD FOR SUPPORTING A DIAGNOSIS OF AN EFFECT OF A TREATMENT BY USING ANTHRACYCLINE ANTICANCER DRUGS AND A DEVICE FOR SUPPORTING A DIAGNOSIS FOR AN EFFECT OF A TREATMENT BY USING ANTHRACYCLINE ANTICANCER DRUGS - A method of supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs is disclosed. The method provides a new value for judging an effect, a judgment score, which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The effect of the treatment by using anthracycline anticancer drugs is judged by comparing the judgment score with a predetermined threshold level. | 10-01-2009 |
20090248317 | BIOLOGICAL SAMPLE ANALYZER AND COMPUTER PROGRAM PRODUCT - The present invention is to present a biological sample analyzer, comprising: a characteristic information obtainer for obtaining characteristic information representing a characteristic of a component contained in a biological sample of a patient; a processor; and a memory storing software instructions adapted to enable the processor to perform operations comprising: (a) analyzing the characteristic information based on a first condition for analyzing a biological sample of a patient who does not have a predetermined attribution; and (b) analyzing the characteristic information based on a second condition for analyzing a biological sample of a patient who has the predetermined attribution. | 10-01-2009 |
20090248318 | SAMPLE ANALYZER, SAMPLE ANALYZING METHOD AND COMPUTER PROGRAM PRODUCT - The present invention is to present a sample analyzer, comprising: a sample preparing section for preparing a measurement sample from a sample and a reagent; a detector for detecting a predetermined component contained in one measurement sample prepared by the sample preparing section; and a data processing section being configured to perform operations comprising: (a) generating a plurality of analysis data for analyzing the predetermined component based on a detection result by the detector; (b) selecting one analysis data from the plurality of analysis data; (c) analyzing the predetermined component based on at least the one analysis data selected in the operation (b); and (d) outputting an analysis result obtained in the operation (c). | 10-01-2009 |
20090254284 | System for providing animal test information and method of providing animal test information - A system for providing animal test information is disclosed that comprises: test devices; and a central device communicably connected to the test devices, wherein each of the terminal test devices comprises: an input receiving section for receiving input of attribution information of a sample; a measurement section for measuring the sample and acquiring a measurement result; an information transmitting section for transmitting a data set of the attribution information and the measurement result to the central device, wherein the central device comprises: an information receiving section for receiving the data set; a data storage for storing a plurality of the data set; a standard value calculation section for calculating a standard value to be used for determining a treatment of an animal, based on a plurality of the measurement result included in a plurality of the data set which have common attribution information. | 10-08-2009 |
20090259407 | APPARATUS AND METHODS FOR NON-INVASIVE MEASUREMENT OF A SUBSTANCE WITHIN A BODY - Embodiments of the present system and methods measure a concentration of a substance, such as glucose, in a body. The present embodiments measure a first amount of infrared (IR) radiation absorbed or emitted from the body in a first wavelength band, and a second amount of IR radiation absorbed or emitted from the body in a second wavelength band. The present embodiments also measure a temperature at a surface of the body and an ambient temperature. A normalized ratio parameter is calculated from the four measurements, and the concentration of the substance in the body is calculated by correlating the normalized ratio parameter with the body surface temperature and the ambient temperature using an empirically derived lookup table. Also disclosed are methods for creating the empirically derived lookup table. | 10-15-2009 |
20090259408 | Analyzing system, data processing apparatus, and storage medium - An analyzing system, data processing apparatus, and storage medium capable of reducing the complex labor of a technician related to the setting operations of a measuring apparatus. The analysis system is provided with a plurality of measuring apparatuses that perform mutually different measurements of specimens, and a data processing apparatus for analysis processing of the measurement results of the plurality of measuring apparatuses. The data processing apparatus is capable of performing various analysis processes of a plurality of types of measurement results variously obtained from a plurality of measuring apparatuses, and is capable of integratedly managing the measurement results of the plurality of measuring apparatuses and their analysis results. | 10-15-2009 |
20090265112 | Device and method for responding to influences of mind - In the field of direct mind-machine interactions, prior art devices and methods do not provide sufficiently fast and reliable results. Mental influence detectors ( | 10-22-2009 |
20090265113 | SYSTEM AND METHOD FOR TESTING HEAT EXCHANGE SYSTEM FOR HEAT EXCHANGE CATHETER - A heat exchange system for an indwelling catheter is tested for proper operation by observing whether a fluid temperature is within a command zone range and if not whether temperature moves toward the range or equalizes with it within predetermined parameters after a pump has stopped, and only if temperature exhibits none of the tested-for conditions indicating an error. | 10-22-2009 |
20090265114 | Influenza virus neuraminidase crystal structure and their use thereof - The invention relates to crystals of the influenza virus neuraminidase protein, their structures and their use. | 10-22-2009 |
20090265115 | METHOD AND APPARATUS FOR ANALYZING DNA - This invention is directed to a protocol and design for an apparatus to analyze the distribution and/or ratio of Thymine, Cytosine, Adenine and Guanine of a DNA sequence from a target organism. The result is then used to determine the possible impact the target organism may have in a host such as a human body. The goal is to provide an effective way to diagnose diseases such as infectious diseases, to test the safety of food and drugs, and therefore to create natural and effective solutions for health care and food supply. For example, a DNA analysis method configured according to the invention receives a DNA sequence input and converts it into a reassembled sequence. A result based on the reassembled sequence may then be output. | 10-22-2009 |
20090265116 | PREDICTION OF AN INDIVIDUAL'S RISK OF DEVELOPING RHEUMATOID ARTHRITIS - Methods for predicting the likelihood of development of rheumatoid arthritis for individuals that present with recent-onset undifferentiated arthritis. The methods are based on the determination of a set of clinical markers and/or parameters and determining a predicted risk for developing rheumatoid arthritis. Clinical markers and parameters that are decisive for the risk for developing rheumatoid arthritis may include serum levels of C-reactive protein, Rheumatoid factors, anti-CCP antibodies, anti-MCV as well as age, gender, localization of the joint complaints, length of morning stiffness, and number of tender and/or swollen joints or combinations thereof. The method may be performed by a computer. The invention further relates to a computer, a sample analyser and a computer program product for performing the method and a data carrier with the computer program product. | 10-22-2009 |
20090271119 | Pertioneal Membrane Function Test Method, Peritoneal Membrane Function Test Apparatus and Peritoneal Membrane Function Test Program - It is intended to provide a method whereby the peritoneal function of a dialysis patient can be tested by a relatively easy procedure and yet a high accuracy can be achieved compared with the existing methods, and an apparatus for the peritoneal function test by using the same. Standards of four kinetic parameters (CCr, Kt/V, MTACu, and MTACc) available in a definite dialysis guideline are computed in accordance with the relational expression (formula (7)). The curve showing the relation between MTACu/c thus obtained and the drained fluid volume is indicated in a graph together with the PET data of the patient which has been prepared separately. Thus, the peritoneal function can be evaluated based on the relative position of the patient's data and the curve showing the standard values in the graph. | 10-29-2009 |
20090271120 | Methods and systems for monitoring bioactive agent use - Methods, computer program products, and systems are described that include accepting at least one indication of a bioactive agent use by an individual and/or assigning an artificial sensory experience to monitor at least one desired effect of the bioactive agent on the individual. | 10-29-2009 |
20090271121 | Methods and systems for detecting a bioactive agent effect - Methods, computer program products, and systems are described that include accepting at least one indication of bioactive agent use by an individual and/or presenting an indication of an artificial sensory experience programmed to detect at least one effect of the bioactive agent at least partly based on the at least one indication of the bioactive agent. | 10-29-2009 |
20090271122 | Methods and systems for monitoring and modifying a combination treatment - Methods, computer program products, and systems are described that include monitoring at least one attribute of an individual during an artificial sensory experience while the individual is under the influence of a bioactive agent, identifying at least one characteristic of the artificial sensory experience that is proximate to a desired change in the at least one attribute of the individual, and/or modifying at least one of the artificial sensory experience or the bioactive agent at least partly based on the identifying at least one characteristic of the artificial sensory experience that is proximate to the desired change in the at least one attribute of the individual. | 10-29-2009 |
20090271123 | ORDERING GENES BY ANALYSIS OF EXPRESSION KINETICS - A method for analyzing the temporal behavior of gene expression for a group of genes which are part of a biological system or subsystem. Preferably, such an analysis enables the order of expression of such genes to be determined. More preferably, the temporal behavior of gene expression is assessed according to the analysis of the kinetics of gene transcription. According to a preferred embodiment of the present invention, the kinetics of gene transcription are measured according to promoter activity of a plurality of genes. More preferably, such kinetics are measured in a living organism or a portion of such an organism, such as a cell for example. For single-celled organisms, such as bacteria for example, the kinetics may easily be measured for the entirety of the living organism. | 10-29-2009 |
20090271124 | DIABETES-RELATED BIOMARKERS AND METHODS OF USE THEREOF - The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes. | 10-29-2009 |
20090276160 | CRYSTAL STRUCTURE OF HEPATOCYTE GROWTH FACTOR ACTIVATOR COMPLEXED WITH KUNITZ DOMAIN INHIBITOR - The present disclosure provides crystals of and structural coordinates of Hepatocyte growth factor activator with and without bound pseudo-substrate or inhibitor. In a specific embodiment, a crystal structure of activated HGFA complexed with a Kunitz domain inhibitor is provided. The crystals and crystal structures are useful, for example, in the design and synthesis of inhibitors of HGFA. | 11-05-2009 |
20090276161 | Heart age assessment - An automated method of determining a measure of a subject's heart age comprising the steps of: prompting a user for a plurality of inputs, each relating to an attribute of the subject, each attribute defining one or more of a demographic status of the subject, a lifestyle status of the subject, a physical condition of the subject and a medical history of the subject; receiving, from the user, a plurality of said inputs; determining from said received inputs, a set of parameters for which input data has been received as input from the user; selecting a heart age calculation algorithm from a predetermined set of heart age calculation algorithms according to said set of parameters; and calculating a heart age for the subject according to the selected algorithm; and providing as output said calculated heart age. | 11-05-2009 |
20090276162 | SENSOR DEVICE AND SENSOR SYSTEM - The invention relates to a sensor device for fastening to human or animal bodies and to a sensor system comprising a plurality of said sensor devices. The sensor devices each comprise a sensor element and a transmission device for the wireless transmission of sensor signals to a receiving device of the sensor system. Thus, universal usability and particularly the suitability to carry out biopotential measurements preferably with automatic detection of configurations is made possible in that the sensor devices each are provided with a connecting device for the electrical connection to a neighboring sensor device and/or a position detection device for detecting the position relative to the neighboring sensor unit. | 11-05-2009 |
20090281733 | METHOD FOR EVALUATING TREE PRODUCTION CAPACITY, IMAGE CAPTURE DEVICE FOR EVALUATING TREE PRODUCTION CAPACITY, AND PROGRAM FOR EVALUATING TREE PRODUCTION CAPACITY - Evaluation of tree production capacity by a non-destructive method using a tree crown structure measurement device or using an image capture device with a fisheye lens mounted, for isolated trees or for trees existing at intervals, is enabled without requiring a large amount of time. | 11-12-2009 |
20090287417 | Method for Detecting a Biochemical Interaction - A method for detecting a biochemical interaction between at least two interaction partners, comprising the steps of bringing into contact the at least two interaction partners, taking a temporal sequence of measurements, each of them producing a measurement value describing the state of the interaction at a given point in time, adapting a mathematical model to the temporal sequence of measurements, whereby the model contains at least one first parameter characterising a temporal phase of increasing measurement values and at least one second parameter characterising a temporal phase of decreasing measurement values, and detecting the biochemical interaction by evaluating the first and second parameter. | 11-19-2009 |
20090287418 | POPULATION OF BACKGROUND SUPPRESSION LISTS FROM LIMITED DATA IN AGENT DETECTION SYSTEMS - Methods and systems are disclosed for detection of agents such as pathogens or toxic substances and, in particular, to methods and systems for determining the most important background constituents to suppress in a sample, e.g., in a bulk aerosol sample, in order to reduce the probability of false alarms and improve the level of detection of potentially harmful airborne agents. | 11-19-2009 |
20090287419 | AGGLUTINATION JUDGMENT METHOD - The present invention provides an agglutination judgment method includes a first step of collecting data of a transmitted light intensity from each of measuring points included in a predetermined region of the reaction pattern, a second step of calculating a parameter representing the dispersion of a transmitted light intensity in the region, and a third step of judging the agglutination or non-agglutination by comparing the parameter thus calculated with a predetermined reference value. | 11-19-2009 |
20090292477 | Method and Apparatus for Screening and Assaying Environmental Sample - A screening measurement technology enabling a prompt determination about whether or not further confirmation is required by another measuring method, for an environmental sample, such as a sample containing dioxins, is provided. A sample solution in which a known amount of antibodies are mixed, is poured into a measurement cell ( | 11-26-2009 |
20090292478 | System and Method for Analysis of Multiple Diseases and Severities - A data processing technique is provided. In one embodiment, a computer-implemented method includes accessing reference deviation maps for a plurality of disease types. The reference deviation maps may include subsets of maps associated with severity levels of respective disease types, and a disease severity score may be associated with each severity level. The method may include selecting patient severity levels for multiple disease types based on the subsets of reference deviation maps. Also, the method may include automatically calculating a combined patient disease severity score based at least in part on the disease severity scores associated with the selected patient severity levels, and may include outputting a report based at least in part on the combined patient disease severity score. Additional methods, systems, and manufactures are also disclosed. | 11-26-2009 |
20090292479 | METHOD FOR ANALYZING IMAGE FROM BIO-DETECTION ANALYZER - A method for analyzing an image from a bio-detection analyzer includes steps of: illuminating a reacted bio-detection carrier having at least one detection spot and at least one positioning spot by at least one light source; capturing a single image of the bio-detection carrier having all of detection-spot images and positioning-spot images by an image capturing unit; defining a reference coordinate location of each of the detection-spot images according to the positioning-spot image; defining an effective detection area of each of the detection-spot images according to the reference coordinate location of each of the detection-spot images; and analyzing an averaged intensity value (such as an averaged gray scale value) of each of the detection-spot images, so as to output the averaged intensity value for showing a reaction result of the reacted bio-detection carrier. | 11-26-2009 |
20090292480 | Synthetic Microfluidic Microvasculature Network - A synthetic microfluidic microvasculature network and associated methods mimic the structure, fluid flow characteristics, and physiological behavior of physiological microvasculature networks. Computational methods for simulating flow and particle adherence in synthetic and physiological microvascular systems and methods for determining parameters influencing particle adhesion and drug delivery are described with applications in the optimization of drug delivery and microvascular treatments and in describing disease mechanisms that affect the microvasculature. | 11-26-2009 |
20090292481 | APPARATUS, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR THERAPY PLANNING IN TREATMENT OF A PATIENT - An apparatus, method, system, computer-readable medium and use for individual patient therapy planning of diseases such as cancer for different therapy modalities, such as radiation therapy and chemotherapy is provided. A new aspect of the invention is that the degree of bone marrow depression of the patient is related to the count of immature blood platelets, which are measured before each treatment. Some embodiments of the invention provide an advantage allowing reducing the level of uncertainty in the prediction of the risk of bone marrow depression, and thus enabling to safely improve the therapy effect by an increase of the radiation dosage and/or chemical dosage to the individual patient while the risk for bone marrow depression is minimized. | 11-26-2009 |
20090299640 | Methods and Compositions Involving Intrinsic Genes - Disclosed are compositions and methods related intrinsic gene sets and methods and compositions related to detecting and classifying cancer. | 12-03-2009 |
20090299641 | METHODS AND APPLICATIONS FOR TARGET QUANTIFICATION - The present invention provides methods and software applications for quantifying a target in an experimental sample by collecting and processing initial signal data from the experimental sample and at least two standard control samples containing known target copy numbers. In this regards, the present invention allows the quantification of target copy number in the experimental sample. | 12-03-2009 |
20090299642 | METHOD - A method of analyzing a keratin sample from a subject to improve sensitivity and specificity of a diagnostic test for a pathological state in the subject by exposing the keratin sample to incident energy derived from an energy source; receiving radiated energy from the keratin sample consequent upon impingement of the incident energy on the keratin sample; passing at least a portion of the radiated energy received from the keratin sample through a transducer so as to derive subject specific data; processing subject specific derived data; comparing the processed subject specific data thus derived with a second group of reference data present in a reference database; wherein the second group of reference data is consistent with a presence of the pathological state in the subject; and including the steps of applying an appropriate algorithm to said subject specific data prior to said step of comparing thereby to improve sensitivity and specificity relative to said reference data. | 12-03-2009 |
20090299643 | Computational Analysis Of The Synergy Among Multiple Interacting Factors - Systems and methods for selecting factors from a data set of measurements are provided. The measurements include values of factors and/or outcomes. Two or more factors that are jointly associated with one or more outcomes from the data set are identified. Each of the two or more factors are analyzed to determine at least one cooperative interaction among the factors with respect to an outcome. The two or more factors can be a module of factors. | 12-03-2009 |
20090299644 | SYSTEM AND METHOD FOR SELECTING SAMPLES FROM AN ANTIBODY ANALYSIS FOR DISPLAY OF COMPLETE SPECIFICITY ANALYSIS DATA - A system and method provides for selecting one or more samples from an antibody specificity analysis for displaying complete antibody specificity analysis data. A plurality of sample sera are run through a protein panel for antibody analysis and a specificity analysis is completed. A positive or negative screening result is displayed for each sample within the panel, and for each positive sample, preliminary diagnostic data such as the PRA value and intensity value are provided. The preliminary diagnostic data is then reviewed by a user to determine whether complete specificity data of each positive sample is needed. In one embodiment, the complete specificity data is available for purchase on a sample-by-sample basis so that if only a small amount of samples are deemed useful, purchase of the complete specificity data for an entire panel of samples is avoided. The specificity data is encrypted until the user decides to purchase it. | 12-03-2009 |
20090299645 | Genetic analysis - The present invention provides methods for generating genetic profiles or analyses. Included are methods for conducting comprehensive, dynamic genetic analysis. Also provided are methods for determining genetic health scores for specific phenotypes, such as diseases, disorders, traits, and conditions, as well as for organ systems, for certain medical specialties, and for overall health. | 12-03-2009 |
20090299646 | System and method for biological pathway perturbation analysis - The invention provides system and methods for analyzing the perturbation of one or more biological pathways. In one embodiment, expression values for each of a plurality of genes for one or more experimental conditions may be received. Gene differential regulation values may then be calculated for each of the plurality of genes across each of the one or more experimental conditions. The gene differential regulation values may then be grouped by the biological pathway and experimental condition from which each gene differential regulation value originated yielding one or more pathway-condition data sets. Pathway perturbation values may then for each of the one or more pathway-condition data sets using the gene differential regulation values. These pathway perturbation values may be clustered, used to identify biological pathways or experimental conditions for further analysis, and/or utilized to build a classifier for classifying additional experimental data. | 12-03-2009 |
20090299647 | METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR IDENTIFYING BINDING CONFORMATIONS OF CHEMICAL FRAGMENTS AND BIOLOGICAL MOLECULES - A new approach to identifying binding conformations of chemical fragments and biological molecules is presented, in which fragment poses are explored in a systematic fashion. In an embodiment, for each pose, a fast computation is performed of the fragment interaction with the biological molecule using interpolation on a grid. Once the energies of fragment poses are computed, thermodynamical quantities such as binding affinity, binding enthalpy, and binding entropy are computed by direct sum over fragment poses. Using the present invention, it is possible to navigate fragment configuration space to identify separate binding modes. The present invention can be used to scan an entire biological molecule to identify possible binding pockets, or it can be used for localized explorations limited to interesting areas of known binding pockets. | 12-03-2009 |
20090299648 | Hydropathy Plots and Fourier Analysis with Ellipsoidal Distance Metric - Techniques for protein structure analysis are provided. In one aspect, an apparatus for characterizing at least a portion of a protein structure comprising amino acid residues is provided. A set of values characterizing the protein structure are determined, wherein each value represents a distance from a center of the protein structure to a center of a given one or more of the amino acid residues. One or more other sets of values characterizing the hydrophobicity of the protein structure are obtained. A Fourier transform is performed on each of the sets of values to obtain transformed values sets. The transformed value sets are compared to correlate the hydrophobicity with the protein structure. | 12-03-2009 |
20090299649 | Hydropathy Plots and Fourier Analysis with Ellipsoidal Distance Metric - Techniques for protein structure analysis are provided. In one aspect, an article of manufacture for characterizing at least a portion of a protein structure comprising amino acid residues is provided. A set of values characterizing the protein structure are determined, wherein each value represents a distance from a center of the protein structure to a center of a given one or more of the amino acid residues. One or more other sets of values characterizing the hydrophobicity of the protein structure are obtained. A Fourier transform is performed on each of the sets of values to obtain transformed values sets. The transformed value sets are compared to correlate the hydrophobicity with the protein structure. | 12-03-2009 |
20090306901 | SYSTEM AND METHOD FOR ABSOLUTE QUANTITATION OF PROTEINS USING LC/MS - Absolute quantitation of protein in a sample is provided by comparing a sum or average of the N highest ionization intensities observed for peptides of a particular protein along with a calibration standard. The calibration standard can be in the form of a table generated by prior protein peptide analysis performed using one or more pre-determined proteins. The comparison is used to determine a corresponding absolute quantity of protein based on the observed sum or average of ionization intensities. A simple conversion factor can be applied to the calibration standard value to determine the absolute quantity of protein in the sample. | 12-10-2009 |
20090306902 | Screening Method - A method for structure-based virtual screening, wherein compounds for investigation are categorized or sorted into a catalog according to their physicochemical and steric properties. The physicochemical and steric properties of a target are determined, the part(s) of the catalog which match the determined properties of the target are determined, and only the compounds in these parts of the catalog are screened against the target. | 12-10-2009 |
20090306903 | COMPOUND SCREENING METHOD AND APPARATUS - A screening apparatus divides measurement data representing the amount of binding between one kind of protein and each of a plurality of kinds of compounds, obtained by a measurement apparatus, into groups, each including data obtained in a same measurement condition. The screening apparatus obtains a representative value of measurement data that is obtained when the protein and a compound are not bound to each other for each of the groups by using the measurement data belonging to the respective groups, and sets a threshold value for extracting a hit compound for each of the groups by using corrected measurement data, obtained by correcting the measurement data for each of the groups so that the representative value obtained for each of the groups becomes the same value. Then, a hit compound is extracted by comparing the threshold value with the corrected measurement data. | 12-10-2009 |
20090306904 | Hydrophobic Moment of Multi-Domain Proteins - Techniques for protein structure analysis are provided. In one aspect, an apparatus for characterizing a multi-domain protein structure comprises the following steps. For at least one domain, a hydrophobic dipole, e.g., defined as a first-order hydrophobic moment of the domain, is calculated. A score representing the orientation of the hydrophobic dipole of the at least one domain relative to a hydrophobic dipole of one or more other domains of the multi-domain protein structure is then calculated. | 12-10-2009 |
20090312951 | Method for Calculation of Statistical Characteristics for a Set of Gene Expression Values - The invention is concerned with the field of analysis of data resulting from gene profiling experiments, and provides a method for calculation of statistical characteristics e.g. standard deviation values for a set of value pairs (X | 12-17-2009 |
20090312952 | Early Diagnosis of Acute Coronary Syndrome - The invention relates to methods for the early diagnosis of Acute Coronary Syndrome. | 12-17-2009 |
20090319191 | METHOD FOR DIAGNOSIS OF AN INFECTIOUS DISEASE STAGE AND DETERMINATION OF TREATMENT - The present invention relates to a means for determining if mammals within a group of mammals is affected by an infection that induces or could induce inflammation, if the mammal is likely to recover or not and if infected whether the mammal should be treated or let to recover untreated. By differentiating infected mammals in a group into different subsets representing differing stages of the progress of the disease the present invention teaches how to prognosticate with continuous data the outcome of a treatment/no treatment decision. | 12-24-2009 |
20090319192 | Measurement Facility, Sensor Unit and Further Processing Unit - A measurement facility comprises at least one sensor unit for measurement and issuing of signals and a further processing unit for receiving and further processing of signals which were measured by the at least one sensor unit, with an interface for detachable connection of the further processing unit to different sensor units. A further processing unit comprises at least one interface for establishing a detachable connection to a sensor unit, in order to form a usable inventive measurement facility. A sensor unit comprises a connection point for establishing the detachable connection to the further processing unit. | 12-24-2009 |
20090319193 | METHODS, SYSTEMS, ALGORITHYMS AND MEANS FOR DESCRIBING THE POSSIBLE CONFORMATIONS OF ACTUAL AND THEORETICAL PROTEINS AND FOR EVALUATING ACTUAL AND THEORETICAL PROTEINS WITH RESPECT TO FOLDING, OVERALL SHAPE AND STRUCTURAL MOTIFS - Methods, systems, algorithms and means for describing, analyzing and predicting protein folding motifs and other structures are provided. In one aspect, the Protein Folding Shape Code (PFSC) methods, systems, algorithms and means of the present invention apply generally to all of the categories of protein analysis and description, and are especially relevant to the geometric analyses and descriptions of proteins from their respective sequences or sequence portions. In a novel approach, the present inventions render analyses with respect to the alpha carbons of five-amino acid elements of a protein, utilizing available data to derive torsion angles and pitch distances, to thereby generate a series of overlapping analyses that can be expressed by a plurality of 27 vectors. Methods, systems and algorithms of the invention can be embodied in any computing device or portion thereof, and are adaptable to describe, analyze and predict the folding and other three-dimensional aspects of the structures of biomolecules such as nucleic acids, carbohydrates and glycoproteins. As yet another advantage, the present invention is adaptable as a tool for describing the conformations of many other organic molecules, and are thus especially suitable for use in the design of drugs, and the discovery and design of molecules which are to be adapted to interact with drugs. | 12-24-2009 |
20090326828 | Optimizing Selection of SRM Transitions for Analysis of Biomolecules by Tandem Mass Spectrometry - Methods for selecting a set of SRM transitions for a peptide of interest include selecting a first transition based on sensitivity criteria and selecting at least a second transition based on selectivity criteria. A determination of the uniqueness of the first transition combined with the at least a second transition is made. When the combination of the first transition and the at least a second transition is determined to be unique to the peptide of interest, a sample containing the peptide of interest is subjected to a SRM workflow by monitoring the first transition and the second transition. Also described is an apparatus for carrying out the methods. | 12-31-2009 |
20090326829 | Method and System for Monitoring Consumable Item Usage and Providing Replenishment Thereof - Method and system for providing a subscription based replenishment transaction of consumable items such as glucose test strips, lancets, and medication, such as insulin, including a data network, a user terminal operatively coupled to the data network, the user terminal configured to receive and transmit data over the data network, and a server terminal operatively coupled to the data network, the server terminal configured to receive from the user terminal a request for establishing an account associated with a consumable item, receive from the user terminal one or more predetermined parameters associated with the account, and generate the account based on the one or more predetermined parameters, where the one or more predetermined parameters include a user specified consumable replenishment level received from the user terminal is disclosed. | 12-31-2009 |
20090326830 | INTERPRETING DNA - Methods for establishing the genotype of a DNA sample, and methods for investigating the potential sources of a DNA sample arising from a plurality of source, are provided, the methods being based on a method including: analysing the sample to produce a data profile for the sample for a locus; proposing a suggested genotype; generating a first stage profile for the locus for the suggested genotype; adjusting the first stage profile to account for one or more factors to give a simulation profile; and comparing the data profile and the simulation profile to provide an indication of the likelihood of the data profile given the suggested genotype. The methods in effect make adjustments to take the first stage profile, potentially through one or more intervening profiles, to the simulation profile, the simulation profile being an anticipation of the data profile which would be expected to occur for that suggested genotype in practice. The methods potentially include adjustments for one or more of preferential amplification and/or stutter and/or allele drop out and/or allele drop in and/or stochastic components and/or noise and/or preferential degradation and/or the relative contributions from the sources. | 12-31-2009 |
20090326831 | Concatenated Scalograms - Embodiments may include systems and methods capable of processing an original signal by selecting and mirroring portions of the signal to create new signals. Any suitable number of new signals may be created from the original signal and scalograms may be derived at least in part from the new signals. Regions of the scalograms may be selected based on a characteristic of the original signal. The selected regions may be concatenated, and a sum along amplitudes across time may be applied to the concatenated regions. Desired information, such as respiration information within the original signal, may be determined from the sum along amplitudes across time. | 12-31-2009 |
20100004871 | Identities, specificities, and use of twenty two (22) differentially expressed protein biomarkers for blood based diagnosis of breast cancer - The present invention discloses twenty two 22 protein biomarkers of breast cancer. More specifically, the present invention discloses the identities, specificities, and uses of up to twenty two (22) protein biomarkers in blood serum for distinguishing between patients with earlier and later stages of breast cancer, patients with benign breast diseases or abnormalities, and normal individuals lacking breast abnormalities. | 01-07-2010 |
20100004872 | METHOD FOR QUANTITATIVE MEASUREMENT OF CARDIAC BIOCHEMICAL MARKERS - This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different cardiac biochemical markers in a serum sample, which can be used for the early diagnosis of cardiovascular diseases and myocardial infarction. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies used for the detection of representative cardiac biochemical markers in a serum sample. | 01-07-2010 |
20100004873 | METHOD OF PROCESSING BIOLOGICAL ANALYSIS DATA AND EXPERT SYSTEM OF BIOLOGICAL ANALYSIS APPLYING THIS METHOD - An expert system of biological analysis includes a collecting engine to collect and represent data resulting from biological measurements carried out on a human or animal subject and defining a biological profile, and personal data relating to the human or animal subject. | 01-07-2010 |
20100004874 | GENE DISCOVERY THROUGH COMPARISONS OF NETWORKS OF STRUCTURAL AND FUNCTIONAL RELATIONSHIPS AMONG KNOWN GENES AND PROTEINS - The present invention also relates to natural language processing and extraction of relational information associated with genes and proteins that are found in genomics journal articles. To enable access to information in textual form, the natural language processing system of the present invention provides systems and methods for extracting and structuring information found in the literature in a form appropriate for subsequent applications. | 01-07-2010 |
20100010746 | Sample analyzer, method for displaying analysis result information of a sample and computer program product - The present invention is to present a sample analyzer comprising: an analysis result information generator for generating analysis result information including an analysis result of a sample; a display; a display controller for controlling the display so as to display the analysis result information generated by the analysis result information generator; an input receiver for receiving an input of a comment to one of the analysis result information; a memory for storing the comment received by the input receiver; and a determiner for determining whether another analysis result information to be displayed on the display meets with a predetermined condition, wherein the display controller controls the display so as to display the another analysis result information and the comment stored in the memory, when the determiner has determined that the another analysis result information meets with the predetermined condition. | 01-14-2010 |
20100010747 | MOLECULAR NETWORK ANALYSIS SUPPORT METHOD AND APPARATUS - A molecular network analysis support method includes receiving designation of a biological phenomenon, extracting an interaction from a molecular network, and calculating a relation strength between the designated biological phenomenon and the extracted interaction. | 01-14-2010 |
20100010748 | Method and system for DNA analysis - The present invention pertains to a process for automatically analyzing nucleic acid samples. Specifically, the process comprises the steps of forming electrophoretic data of DNA samples with DNA ladders; comparing these data; transforming the coordinates of the DNA sample's data into DNA length coordinates; and analyzing the DNA sample in length coordinates. This analysis is useful for automating fragment analysis and quality assessment. The automation enables a business model based on usage, since it replaces (rather than assists) labor. This analysis also provides a mechanism whereby data generated on different instruments can be confidently compared. Genetic applications of this invention include gene discovery, genetic diagnosis, and drug discovery. Forensic applications include identifying people and their relatives, catching perpetrators, analyzing DNA mixtures, and exonerating innocent suspects. | 01-14-2010 |
20100017140 | METHODS FOR ANALYSIS OF MicroRNA - The present invention concerns a method for identifying the functionality of each member of a family of nucleic acids interact with the first family. Nucleic acids from the first family are put into functionally related clusters that share biological information obtained from the second family. The invention also relates to the refinement and accurate prediction of interactions between the first family and the second family of nucleic acids. The invention also applies to the use of such functional information to identify targets and mechanisms for therapeutic applications. | 01-21-2010 |
20100017141 | CALCULATING INSULIN ON BOARD FOR EXTENDED BOLUS BEING DELIVERED BY AN INSULIN DELIVERY DEVICE - A system and method may be used to calculate insulin on board (IOB) for an extended bolus being delivered by an insulin infusion pump. In general, the system and method calculates an extended bolus IOB value for the extended bolus, which takes into account the insulin currently on board from the extended bolus and the insulin scheduled to be delivered by the extended bolus over a subsequent time period equivalent to a duration of insulin action. The extended bolus IOB value may be used to calculate a suggested bolus. | 01-21-2010 |
20100017142 | Low Perfusion Signal Processing Systems And Methods - In some embodiments, systems and methods for identifying a low perfusion condition are provided by transforming a signal using a wavelet transform to generate a scalogram. A pulse band and adjacent marker regions in the scalogram are identified. Characteristics of the marker regions are used to detect the existence of a lower perfusion condition. If such a condition is detected, an event may be triggered, such as an alert or notification. | 01-21-2010 |
20100017143 | GESTATIONAL AGE DEPENDENT PROTEOMIC CHANGES OF HUMAN MATERNAL SERUM FOR MONITORING MATERNAL AND FETAL HEALTH - The present invention concerns a global maternal serum proteome map and its changes during healthy gestation. Accordingly, the present invention provides an important tool for plasma-based maternal-fetal diagnostics. | 01-21-2010 |
20100017144 | Lung cancer evaluating apparatus, method, system, and program and recording medium therefor - According to the method of evaluating lung cancer, amino acid concentration data on the concentration value of amino acid in blood collected from a subject to be evaluated is measured, and a lung cancer state in the subject is evaluated based on the concentration value of at least one of Orn, Lys, ABA, Arg, Glu, His, Tau, Pro, Ala, Cit and Ile contained in the measured amino acid concentration data of the subject. | 01-21-2010 |
20100017145 | METHOD OF EVALUATING CANCER STATE, CANCER-EVALUATING APPARATUS, CANCER-EVALUATING METHOD, CANCER-EVALUATING SYSTEM, CANCER-EVALUATING PROGRAM AND RECORDING MEDIUM - According to the method of evaluating cancer state of the present invention, amino acid concentration data on the concentration value of amino acid in blood collected from a subject to be evaluated is measured, and a cancer state in the subject is evaluated based on the concentration value of at least one of Cys, Gln, Trp, Orn, Arg, Glu, His, Ser and ABA contained in the measured amino acid concentration data of the subject. | 01-21-2010 |
20100017146 | AUTO-ANALYSIS FRAMEWORK FOR SEQUENCE EVALUATION - An automated system for evaluating biological samples which includes a centralized registry that contains protocols and configuration information for both instruments and analysis applications. The registry provides for improved automation of biological process runs using an autoanalysis applications manager component or daemon, which accesses and transmits the appropriate protocol and configuration information to selected instruments and/or applications. This information is used to instruct data capture by the biological instruments and direct the analysis of the data by the analysis applications. | 01-21-2010 |
20100017147 | Amino-acid biosensor, Fischer-ratio biosensor and health information management system - Disclosed is a biosensor capable of measuring a total concentration of plural types of amino acids. An amino-acid biosensor ( | 01-21-2010 |
20100023270 | Electrodes With Multilayer Membranes And Methods Of Making The Electrodes - A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes at least one layer of a polyanionic or polycationic material. The assembled layers of the membrane are typically disposed in an alternating manner. The sensor also optionally includes a biocompatible membrane. | 01-28-2010 |
20100023271 | Data input support system for gene analysis - A data input support system is provided to preliminarily remove particular error causes when genotype data are input for a program to execute linkage disequilibrium analysis or the like. By taking advantage of limiting conditions characteristic of genotype input data and the statistical properties of the entire data set, possible errors are detected by a preprocessing program, the detected errors are associated with false descriptions causing them to report the results, user input responding to the reported results is accepted, and a modified version of the input data is output. | 01-28-2010 |
20100023272 | Expression Data Analysis Systems and Methods - Methods and applications of Global Patter Recognition (GPR), including a system for analyzing the results of real-time polymerase chain reaction (RT-PCR) experiments employing micro-titer and/or microarray plates and robotic plate readers is described. The system employs a set of self-normalizing housekeeping primers or oligonucleotides on the plates/arrays and an algorithmic approach to normalizing expression data from all primers on the plate based on the reaction products of several of the self-normalizing gene primers oligonucleotides. Normalization is accomplished using simplex reactions involving these self-normalizing primers/oligonucleotides; the normalization parameters are then useable across all control and experimental reactions of the plate/array. A ranked list of genes whose amount of change is statistically significant can be determined. The accuracy of this list is enhanced by the data normalization aspect of the system. Other applications of GPR are also disclosed herein. | 01-28-2010 |
20100023273 | Characterization of Phenotypes by Gene Expression Patterns and Classification of Samples Based Thereon - Generally, the present invention applies a transformation to convert a probability distribution of gene expression signals in control samples to a uniform distribution. The uniform distribution allows better comparisons between expression levels for genes. The transformation is derived from gene expression signals of control data, and is applied to gene expression signals of phenotype data. The phenotype data can be represented in a matrix format. A number of gene expression patterns may be determined (in the form of submatrices) that will characterize the phenotype. The uniform distribution helps in this regard, as it allows better comparisons of patterns. The gene expression patterns can then be used to classify samples as belonging to the phenotype set. Preferably, a discriminant function is used to compare a sample with the gene expression patterns that characterize the phenotype. The discriminant function can determine a score that can be used to determine whether the sample belongs to the phenotype. | 01-28-2010 |
20100030480 | DEVICE AND METHOD FOR EXAMINATION AND EVALUATION OF A BIOLOGICAL ACTIVE AND/OR BIOLOGICAL ACTIVATABLE SUBSTANCE - The invention relates to a device and method for optical examination and for evaluation of a biological active and/or biological activatable substance ( | 02-04-2010 |
20100030481 | Dating hemorrhage - Systems and techniques for dating hemorrhage. In one aspect, a method includes receiving one or more hemorrhage samples that provide information relevant to dating of a hemorrhage, receiving timing information describing timing of the hemorrhage, staining the hemorrhage samples with two or more stains, quantifying two or more parameters that quantitatively characterize two or more properties of the hemorrhage samples on the basis of the staining by the two or more stains, and forming a hemorrhage database that includes the timing information in association with the staining parameters. | 02-04-2010 |
20100030482 | Real-Time Swimming Monitor - A wearable device for monitoring and providing real-time feedback about a swimmer's body motion and performance, in particular, body orientation and forward speed, is provided. The device comprises a three-axis accelerometer, optionally a three-axis gyroscope, a memory, and a microcontroller configured to process the sensor input, calculate a swimmer's performance and provide feedback to the swimmer through an output. The output can be an earpiece or a swimming goggle with a digital display. | 02-04-2010 |
20100030483 | ASSESSMENT METHOD TO PROCESS A GLUCOSE CONCENTRATION SIGNAL AND DEVICES THEREOF - Embodiments of an assessment method for processing a signal corresponding to a glucose concentration and performing a retrospective analysis comprises the steps of: a) initiating a first trigger, wherein the first trigger defines the beginning of a segment of a continuous measurement of glucose concentration or defines the first of a series of spot measurements of glucose concentration; b) collecting data of the continuous measurement or the series of spot measurements of glucose concentration to be analyzed, wherein the collected data relates to a glucose concentration excursion corresponding to a reaction to a relevant event such as a meal or physical activity; c) analyzing the collected data initiated by a second trigger, wherein the second trigger defines the end of the collected data to be analyzed, wherein a measure for a grading of the excursion is determined from the collected data, and d) displaying the results of the analysis. | 02-04-2010 |
20100030484 | SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR - Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk. | 02-04-2010 |
20100030485 | SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR - Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk. | 02-04-2010 |
20100036615 | Method for Measuring Information of Technical and Biological Systems - The invention relates to a method for measuring potential information of a biological or technical system. The aim of the invention is to receive signals using less energy. To achieve this, random generators are used as receivers of low-energy quanta, since the random generators can be regarded and implemented as antennae and receivers of signals of this type. The extensive natural transmission range of low-energy quanta can also be used to receive potential information from systems. | 02-11-2010 |
20100036616 | Normalization of Gene Expression Data - A method for determining bias across two domains comprising gene expression data. The method can comprise (a) providing a first domain and a second domain; (b) obtaining information indicative of a bias within the first domain; (c) obtaining information indicative of a bias within the second domain; and (d) using the information indicative of the bias within the first domain and the information indicative of the bias within the second domain to produce an indication of bias across the two domains. | 02-11-2010 |
20100042329 | MULTIPARAMETER ANALYSIS FOR PREDICTIVE MEDICINE - The invention provides a method of determining a comparative expression profile in an individual by comparing the expression levels of a sample of molecules in a population of molecules in a specimen from the individual with a health-associated reference expression region of the sample of molecules, wherein expression levels within the health-associated reference expression region indicate a reference expression profile and wherein expression levels outside the health-associated reference expression region indicate a perturbed expression profile. The invention also provides methods of diagnosing a disease or a health state in an individual by comparing the expression level of a sample of molecules in a specimen from the individual with a health-associated reference expression region of the sample of molecules. | 02-18-2010 |
20100042330 | Non-Hypergeometric Overlap Probability - Methods, software, and systems are provided for determining the probability of an overlap set of entities having an overlap size, where the overlap set is independently selected from two sets of non-identical entities. Applications of the invention to microarrays are provided. Probability distributions are provided for determining the probability that the size of an overlap gene set from two different microarrays occurs by chance. Microarray analysis for determining the size of a statistically significant overlap gene set given two different microarrays is described. Overlap set size probability determinations that account for the total number of genes in two different microarrays and not just the common genes are described. | 02-18-2010 |
20100042331 | PLANNING METHOD AND APPARATUS FOR PERITONEAL DIALYSIS AND HEMODIALYSIS HYBRID REMEDY - The present invention is a peritoneal dialysis and hemodialysis hybrid-remedy planning method using an index that is shared by both peritoneal dialysis and hemodialysis and indicates an effect of dialysis. To be specific, the index is M/C(0)/V | 02-18-2010 |
20100049444 | CALIBRATION SURFACE METHOD FOR DETERMINATION OF ANALYTE RATIOS - The ratio of analytes is determined directly from the responses of the analytes using a conversion method. Individual analyte responses are obtained by using a selected measuring technique, and these individual responses are used as the independent variables in a conversion method. The dependent variable of conversion method is the desired analyte ratio. The resulting conversion method is then used to directly calculate the desired ratio of analytes as a function of the measured responses. No intermediate conversions, such as using a calibration curve to convert individual measured analyte responses to concentration values, are needed to obtain the desired ratio. | 02-25-2010 |
20100049445 | METHOD AND APPARATUS FOR SEQUENCING DATA SAMPLES - A method for identifying non-host nucleic acid sequence using sequence data. The method of identifying non-host nucleic acid can include sequencing a sample into sequences and associating the sequences with a host genome and then exclude any sequences that are associated with the host genome. The method can then associate the sequences with any known genomes and exclude any sequences that are associated with any known genome. The remaining sequences can be used as seed sequences to assemble a non-host nucleic acid. | 02-25-2010 |
20100049446 | GENE CLASSIFYING METHOD, GENE CLASSIFYING PROGRAM, AND GENE CLASSIFYING DEVICE - A gene classifying method is provided and includes acquiring expression levels of a plurality of genes at a plurality of observation points, generating a binary string by taking a positive or negative difference in expression level in a temporal passage direction of the observation points for each gene, and classifying the genes on the basis of all plus and minus patterns that the binary strings can have and the generated binary strings. | 02-25-2010 |
20100049447 | Method of modeling the behavior of an eye subjected to an external force - A method for simulating the behavior of an eye comprising the steps of (i) generating a FEM model of the eye representing the physical structure of the eye, the FEM model including an elastic walled corneo-scleral shell, (ii) modeling deformations of the eye with the FEM model, the deformation modeling including the simulated application of at least one external force to the FEM model, and (iv) obtaining FEM model solutions iteratively in an incremental fashion, whereby adjustable nodal pressure is introduced inside the corneo-scleral shell. | 02-25-2010 |
20100049448 | MULTIDIMENSIONAL MORPHOLOGICAL RECONSTRUCTION OF GENOME EXPRESSION ACTIVITY - A method of morphological reconstruction of biological activity in a tissue sample maps biological data resulting from analysis of tissue samples onto a 3-D morphological rendering of the biological sample. Each slice in a set of histological slices, indexed by a first index, is micro dissected into micro samples indexed by a pair of first and second indices. The indices are utilized to spatially map biological data to the 3-D rendering. | 02-25-2010 |
20100057368 | Biological Systems Analysis - Disclosed are methods for the practice of systems pharmacology, systems toxicology, and systems pathology using patterns, such as images, reflective of the biological state of subjects such as humans or experimental mammals. The patterns are generated from data obtained from one or more samples from one or more subjects by applying certain data treatment techniques, and are reflective of the biochemistry of the subjects. The patterns are used in drug selection and discovery, assessment of toxicity and drug efficacy, segmentation of populations, discovery of disease subtypes, as surrogate end points, in the assessment of therapeutic options, and for diagnosis and prognosis of disease. | 03-04-2010 |
20100057369 | Corrective methodology for processing results of transcriptome experiments obtained by differential analysis - A corrective method for processing results of transcriptome experiments obtained by differential analysis includes the following steps:
| 03-04-2010 |
20100057370 | Nucleotide Sequence Screening - A system for screening nucleotide sequences, a method therefor, a program, a recording medium, and a server on which the screening of nucleotide sequences is executed. The solution comprises a step of storing target nucleotide sequence data and a probe nucleotide sequence, a step of generating complementary sequence data from a probe nucleotide sequence that may be bound to the target nucleotide sequence, and storing a maximum acceptable edit distance between the target nucleotide sequence and the probe nucleotide sequence, a step of reading out each nucleotide sequence data and the maximum edit distance from each storing unit, and evaluating the binding possibility of the target nucleotide sequence data and the complementary sequence data in descending order of edit distance, and a step of storing the result of the binding evaluation in a storage unit. | 03-04-2010 |
20100057371 | DETERMINATION OF THE INTEGRITY OF RNA - Methods, systems, and apparatus make a determination of a level of integrity of a sample of biomolecules. For example, the determination of the integrity of RNA in a sample may be done in a fast and reproducible manner, such that the user can be assured of accuracy of a test (e.g. quantitative polymerase chain reaction qPCR) on the sample and compare results of different samples. The determination of integrity of an RNA sample is performed by comparing a size profile to reference size profiles (degradation standards) obtained from degradation over different lengths of times. As the reference scale of the level of integrity is derived from the actual degradation that occurs in a sample, high accuracy, reproducibility, and efficiency is provided. | 03-04-2010 |
20100063740 | Rechargeable Biosensor - A rechargeable biosensor for the quantitative determination of an analyte is disclosed. The rechargeable biosensor mainly comprises a charging circuit, a charge storage circuit, and an operation circuit. The charging circuit may be selectively electrically coupled to an external power source for receiving a voltage; the charge storage circuit is electrically coupled to the charging circuit and being rechargeable by the charging circuit when the charging circuit is electrically coupled to the external power source; the operation circuit is electrically coupled to the charge storage circuit for receiving an operation voltage from the charge storage circuit, wherein the operation circuit is adapted to measure an electrical signal derived from the analyte and output a quantitative property of the analyte. | 03-11-2010 |
20100063741 | CALCULATING SAMPLE SIZE FOR CLINICAL TRIAL - A method for calculating a sample size for a clinical trial of a first treatment can be provided. The method can include reading a survival curve from a clinical trial for a second treatment, wherein the clinical trial may be selected by a user interacting with a user interface. The method can further include selecting a plurality of points on the survival curve and storing coordinates for each of the plurality of points, wherein the plurality of points are selected so as to capture substantial features of the survival curve. Then, a hazard curve is generated based on the coordinates that were stored, wherein the hazard curve may be a step function. The method can further include calculating a sample size for the clinical trial of the first treatment using a Markov model based on the hazard curve. | 03-11-2010 |
20100063742 | MULTI-SCALE SHORT READ ASSEMBLY - The invention generally provides methods for analyzing and constructing nucleic acid sequences and more specifically for assembling a collection of short read nucleic acid sequences to construct longer nucleic acid sequences. | 03-11-2010 |
20100063743 | Methods And Compositions For Base Calling Nucleic Acids - The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses. | 03-11-2010 |
20100063744 | SMALL ORGANISM LOCOMOTOR RECORDING PROCEDURE AND DEVICE, BEHAVIORAL RECORD OBTAINED AND USE OF SAME - The system records the movement of tiny organisms housed in closed micro plates traversed by an infrared beam generating a signal as a function of the diffraction caused by the body of the microorganism. The behavior detection procedure includes processing the diffraction signal to discriminate the locomotor activity of the microorganism. The system may be used in the chronobiological field, longevity, toxicity, and pharmacology studies. | 03-11-2010 |
20100063745 | METHOD OF ESTIMATING SECONDARY STRUCTURE IN RNA AND PROGRAM AND APPARATUS THEREFOR - Assuming frame F having specific short length L | 03-11-2010 |
20100063746 | SYSTEM AND METHOD FOR DETERMINING A RISK RATING PROFILE OF SPECIFIC HORTICULTURAL ASSET PLANT SPECIES, INDIVIDUAL PLANTS AND A STAND OF PLANTS - In one embodiment, the invention may provide a system and method for determining the risk factor of individual and groups of plants by identifying a plant. Various characteristics about the plant or group of plants may then be collected and uploaded into a database. Local environmental characteristics may also be uploaded to determine the likelihood that certain adverse environmental factors may affect the plant. The uploaded characteristics of the plant and environmental factors may then be compared with predefined ratings associated with each characteristic and the ratings can be used to determine if the plant or group of plants might fail. Using this information, a risk factor for the property on which the plant or group of plants are located may be determined. | 03-11-2010 |
20100063747 | Using Plasma Proteomic Pattern For Diagnosis, Classification, Prediction of Response to Therapy and Clinical Behavior, Stratification of Therapy, and Monitoring Disease in Hematologic Malignancies - The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra from the plasma samples with or without fractionation; comparing the protein spectra with clinical data; and identifying protein markers in the plasma samples that correlate with the clinical data. Protein markers identified by this approach can then be used to create a protein profile that can be used to diagnose the hematologic malignancy or determine the prognosis of the hematologic malignancy. Potentially these specific proteins can be identified and targeted in the therapy of these malignancies. | 03-11-2010 |
20100070184 | METHOD FOR DETERMINING RESISTANCE OF HIV TO PROTEASE INHIBITOR TREATMENT - The present invention provides methods and devices for predicting whether an HIV-I is likely to have a reduced susceptibility to an antiviral drug based on the HIV-I's genotype. In one aspect, the invention provides methods comprising determining whether a mutation or combination of mutations associated with altered susceptibility to protease inhibitors are present, as disclosed herein, thereby assessing the effectiveness of tipranavir therapy in the HIV-infected subject. Computer implemented methods comprising determining HIV-I's altered susceptibility are provided. | 03-18-2010 |
20100070185 | REAL-TIME PCR ELBOW CALLING BY EQUATION-LESS ALGORITHM - Systems and methods for determining a transition value in a sigmoid or growth curve, such as the end of the baseline region or the elbow value or Ct value of a PCR amplification curve. Numerical determinations of the second derivatives and curvature values of a PCR data set are made. A Gaussian Mixture Model (GMM) function with parameters determined using a Levenberg-Marquardt (LM), or other, regression process is used to find an approximation to the second derivative values and to the curvature values, where the maximum values of the numerically determined second derivative values and/or curvature values are used as initial conditions for parameters of the GMM function. The determined parameters provide fractional Ct values. The Ct value(s) are then returned and may be displayed or otherwise used for further processing. | 03-18-2010 |
20100070186 | METHODS OF SCREENING FOR AND MAPPING PHENOTYPIC AND GENOTYPIC VARIATIONS IN CELLS - Described herein are methods of mapping in cultured cells a recessive genotypic or phenotypic variation to a region of a genetic sequence, methods of screening cells in. cell culture for genotypic or phenotypic variations, methods of mutagenizing cells, and methods of using genetic sequences identified by one or more methods described herein. | 03-18-2010 |
20100070187 | HUMAN RECOGNITION APPARATUS AND HUMAN RECOGNITION METHOD - Provided are a human recognition apparatus and a human recognition method identifying a user based on a walking pattern. The human recognition apparatus includes a detecting unit detecting a vibration according to a user's walking, and outputting an electric signal, a pattern calculating unit acquiring a walker's walking pattern from the electric signal, and a user determining unit comparing the walking pattern with a previously measured reference data by user and identifying the user based on the comparison result. The human recognition apparatus and the human recognition method are robust against peripheral noise and can increase an acceptance rate through a simple structure and procedure by using the waling pattern, which is one-dimensional time information requiring no vast data throughput, as the user identification data. | 03-18-2010 |
20100070188 | Intelligent medical device system for on-demand diagnostics - The system describes the diagnostic procedures involving the intelligent medical device (iMD) system. After data is collected from a patient by using cellular and molecular samples, the device detects and analyzes pathology. The system uses lab on a chip | 03-18-2010 |
20100070189 | METHOD FOR ASSESSING DEGREE OF RELIABILITY OF NUCLEIC ACID BASE SEQUENCE - Disclosed herein is a method for assessing the degree of reliability of a nucleic acid base sequence, by which a higher-accuracy assessment result of the degree of reliability can be obtained as compared to a case where the degree of reliability is assessed based on only the evaluation of analytical data. The method includes the steps: (A) when measured data is processed into analytical data, computing a processing evaluation value E1 | 03-18-2010 |
20100070190 | MULTI-STAGE, REGRESSION-BASED PCR ANALYSIS SYSTEM - Systems and methods are provided for analyzing data to determine properties of a PCR process or other process exhibiting amplification or growth. Data representing an amplification can be distinguished from data representing a jump or other error. A modified sigmoid function containing a drift term may be used in determining the properties. A multi-stage functional fit of the amplification data can provide increased accuracy and consistency of one or more of the properties. A baseline of the amplification data can be determined by analyzing an integrated area of a first derivative function of the data. A reference quantitation value can also be determined from locations of maxima of different derivative functions of the amplification data, e.g., a weighted average of the maxima locations for the second and third derivatives may be used. | 03-18-2010 |
20100070191 | Lung Cancer Biomarkers and Uses Thereof - The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, Col. 2, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value. | 03-18-2010 |
20100070192 | OPTIMIZATION OF CROSSOVER POINTS FOR DIRECTED EVOLUTION - Methods and devices for more efficiently engineering diversity into recombinant polypeptides and/or nucleic acids are provided herein. For example, a variety of methods of selecting and/or assessing potential crossover sites in an amino acid sequence or a nucleotide sequence are provided, as well as the resulting chimeric product sequences. These methods include, e.g., consideration of structural, functional and/or statistical data in the selection and assessment of sequences and crossover sites for use in recombination. | 03-18-2010 |
20100070193 | GEOLOCATION SYSTEM AND METHOD FOR DETERMINING MAMMAL LOCOMOTION MOVEMENT - An example geolocation system for mounting on a mammal incorporates simple sensing sleeves on the calves of the body support members, combined with an accelerometer based gravity direction and force sensing at the center of mass of the body. The example system is connected to a digital processing unit and a battery power supply to integrate the sensing to determine kinetic and potential energy of the body locomotion over time in a method that integrates out the aperiodic motion of the body about the center of mass, and uses the residual motion to measure the center of mass locomotion from a known point. | 03-18-2010 |
20100070194 | METHODS FOR RAPID IDENTIFICATION AND QUANTITATION OF NUCLEIC ACID VARIANTS - There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass measurement of resulting amplification products by mass spectrometry, and determination of the base compositions of the amplification products. | 03-18-2010 |
20100070195 | COMPUTER-IMPLEMENTED BIOLOGICAL SEQUENCE IDENTIFIER SYSTEM AND METHOD - A method of: submitting reference sequences to a taxonomic database to produce taxonomic results; and reporting a taxonomic identification based on the taxonomic results. The reference sequences are the output of genetic database queries that return a score for each reference sequence. A method for processing a biological sequence obtained from an assay by: converting base calls located in a predetermined list of positions within the biological sequence to N; and determining the ratio of single nucleotide polymorphisms in the biological sequence relative to a reference sequence. Each entry in the predetermined list of positions represents the capability of a substance hybridizing to a microarray used to generate the biological sequence. The substance is not the nucleic acid of a target pathogen. | 03-18-2010 |
20100070196 | Blood Glucose Tracking Apparatus and Methods - A measurement module for glucose testing includes a glucose testing measurement module housing, a test strip receptacle formed in the housing, and a connector portion formed in the housing and shaped to permit mechanical removable attachment of the housing to a hand-held computer. Electronics determine the amount of glucose present in a sample of body fluid, when the test strip is positioned in the receptacle and the body fluid is placed on a test strip, and communicate the glucose amount to the hand-held computer via the connector portion. | 03-18-2010 |
20100076689 | Method for extracting waveform attributes from biological signals - A computer-based method for extracting waveform attributes from a biological (bio) signal includes the steps of receiving a raw waveform data corresponding to the bio signal, upon receiving a user-initiated signal, communicating the raw data to a first waveform analysis tool to obtain a first waveform attribute, and upon receiving the same user-initiated signal, communicating the raw data to a second waveform analysis tool to obtain a second waveform attribute. The first tool is different from the second tool and the first attribute is different from the second attribute. The method also includes outputting the first and second waveform attributes into a human-readable format. | 03-25-2010 |
20100076690 | METHOD AND SYSTEM FOR ANALYSIS OF MELT CURVES, PARTICULARLY dsDNA AND PROTEIN MELT CURVES - A computer-implemented method of analysis of melt curve data comprising the steps of: (a) parameter model fitting the melt curve data; (b) performing a principal component analysis of the melt curve data; and (c) utilizing the principal components for clustering the melt curve data into groups. Such a method allows an efficient analysis of variations in melt curve shape and position and allows to statistically quantify these variations for both supervised and unsupervised data sets. Current melt analysis methods neither allow for statistical measures of each unknown nor do they allow for the determination of unsupervised data sets (i.e., unknown number of groups present). Particularly, the method according to the invention can be advantageous for identifying a specific sequence of dsDNA in a sample after performing a polymerase chain reaction (PCR). | 03-25-2010 |
20100076691 | Diagnosis of Metastatic Melanoma and Monitoring Indicators of Immunosuppression Through Blood Leukocyte Microarray Analysis - The present invention includes compositions, systems and methods for the early detection and consistent determination of metastatic melanoma and/or immunosuppression using microarrays by calculating one or more expression vectors from the expression of one or more genes. | 03-25-2010 |
20100076692 | Movement And Event Systems And Associated Methods - A method for monitoring fractional weight supported by one foot of a person, comprising the steps of adhering a movement monitor device underneath the foot such that the device is compressed when weight is applied to the foot; generating wireless signals representative of a target fractional weight of a total weight of the person; remotely receiving the wireless signals as information of the fractional weight. A method of monitoring weight of a person, comprising the steps of arranging one or more weight sensitive detectors underneath a foot of the person; processing signals from the detectors to determine weight; and wirelessly communicating the weight to a remote receiver. | 03-25-2010 |
20100082261 | Genetic Diagnosis Using Multiple Sequence Variant Analysis - The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention is useful to define the subset of variations that are most suited as genetic markers to search for correlations with certain phenotypic traits. Additionally, the insights are useful for the development of algorithms and computer programs that convert genotype data into the constituent haplotypes that are laborious and costly to derive in an experimental way. The invention is useful in areas such as (i) genome-wide association studies, (ii) clinical in vitro diagnosis, (iii) plant and animal breeding, (iv) the identification of micro-organisms. | 04-01-2010 |
20100082262 | HAPLOTYPE ESTIMATING APPARATUS AND PROGRAM - The present invention calculates a sum of the count numbers for each of the marker sites to obtain a maximum value of the sum of the count numbers, enumerates polymorphic identification characters up to the count numbers of the polymorphic nucleotides, permutates the enumerated polymorphic identification characters so as to create any character string that has copy units of which the number equals the maximum value, divides the character string into two by the copy unit to store the divided strings as a combination of the haplotype character strings, calculates the number of identical haplotype character strings in the group, obtains a frequency of the haplotype character string in the group, and estimates the combination of the haplotype character strings (representing haplotypes) of each individual of which frequency satisfying a predetermined condition. | 04-01-2010 |
20100088036 | Hair Coloring Method and Hair Coloring Selection Method - A method for hair coloring and selecting a hair colorant formulation based on hair type that minimizes variations in resultant hair color among different users having different hair types. | 04-08-2010 |
20100088037 | Method for Identification and Development of Therapeutic Agents - The present invention relates generally to the field of identification and determination of bioactive amino acid sequences. In particular, the present invention provides method(s) for determining the influence of variation in host genes on selection of microorganisms with particular amino acid variants for the purpose of therapeutic drug or vaccine design or individualisation of such treatment. The invention also provides methods for identifying HLA allele-specific microorganism sequence polymorphisms that result from HLA restriction of antigen-specific cellular immune responses. It also provides diagnostic and therapeutic methodologies that may be used to measure or treat infection by a microorganism or to prevent infection by the microorganism. | 04-08-2010 |
20100094560 | METHODS FOR DIAGNOSING IRRITABLE BOWEL SYNDROME - The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with irritable bowel syndrome (IBS). In particular, the present invention is useful for classifying a sample from an individual as an IBS sample using a statistical algorithm and/or empirical data. The present invention is also useful for ruling out one or more diseases or disorders that present with IBS-like symptoms and ruling in IBS using a combination of statistical algorithms and/or empirical data. Thus, the present invention provides an accurate diagnostic prediction of IBS and prognostic information useful for guiding treatment decisions. | 04-15-2010 |
20100094561 | APPARATUS AND METHOD FOR PROCESSING BIOLOGICAL INFORMATION - A biological information processing apparatus includes the following elements. A light source irradiates biological tissue with light. A transducer functions as an ultrasonic wave transmitting unit that applies an ultrasonic wave to a local region in the biological tissue. A photodetector detects modulated light obtained by modulating the light from the light source with the ultrasonic wave in the local region. The transducer also functions as an acoustic wave detecting unit that detects an acoustic wave emitted from the local region at a time when the local region absorbs the light from the light source. An absorption characteristic in the local region is calculated using an acoustic signal, serving as an output of the acoustic wave detecting unit, on the basis of a light intensity in the local region calculated based on a modulation signal, serving as an output of the photodetector. | 04-15-2010 |
20100094562 | System, Method and Device for Comprehensive Individualized Genetic Information or Genetic Counseling - A method and system for analysis of genetic information. Preferably, such analysis enables genetic counseling to be provided to a patient and/or relative, in which such counseling includes conveying at least one aspect of the analysis in lay terms. | 04-15-2010 |
20100100331 | SYSTEMS AND METHODS FOR BIOPOLYMER ENGINEERING - Methods, computer systems, and computer program products for biopolymer engineering. A variant set for a biopolymer of interest is constructed by identifying, using a plurality of rules, a plurality of positions in the biopolymer of interest and, for each respective position in the plurality of positions, substitutions for the respective position. The plurality of positions and the substitutions for each respective position in the plurality of positions collectively define a biopolymer sequence space. A variant set comprising a plurality of variants of the biopolymer of interest is selected. A property of all or a portion of the variants in the variant set is measured. A sequence-activity relationship is modeled between (i) one or more substitutions at one or more positions of the biopolymer of interest represented by the variant set and (ii) the property measured for all or the portion of the variants in the variant set. The variant set is redefined to comprise variants that include substitutions in the plurality of positions that are selected based on a function of the sequence-activity relationship. | 04-22-2010 |
20100100332 | DETERMINATION OF MELTING TEMPERATURES BY EQUATION-LESS METHODS - Numerical determinations of the first derivatives of a melt curve data set are made. A model function, such as a Gaussian Mixture Model (GMM) function, with parameters determined using a Levenberg-Marquardt (LM) regression process is used to find an approximation to the first derivative curve. The maximum values of the numerically determined first derivative values are used as initial conditions for parameters of the model function. The determined parameters provide one or more fractional melting temperature values, which can be returned, for example, displayed or otherwise used for further processing. | 04-22-2010 |
20100100333 | HUMAN BIOMARKER HYPERMAPPING FOR DEPRESSIVE DISORDERS - Materials and Methods related to diagnosing depression disorders, or determining a subject's predisposition to develop a depression disorder, using a multi-parameter hypermapping system and algorithms related thereto. | 04-22-2010 |
20100100334 | LIPOPROTEIN INSULIN RESISTANCE INDEXES AND RELATED METHODS, SYSTEMS AND COMPUTER PROGRAMS FOR GENERATING SAME - Methods, reports and systems for generating insulin resistance indexes for assessing decreased insulin sensitivity and/or levels of insulin resistance using a plurality of different measured lipoprotein particle parameters. | 04-22-2010 |
20100106423 | METHOD AND APPARATUS FOR ASSESSING FEASIBILITY OF PROBES AND BIOMARKERS - The quantitative evaluation of biomarker-probe activity is disclosed. In certain embodiments, the biomarker-probe activity may be quantified and analyzed using biodistributions generated using a model. In some embodiments, such biodistributions may be used to generate simulated images from which quantitative thresholds may be derived. In some embodiments, the quantitative thresholds may be used to analyze the biodistributions. | 04-29-2010 |
20100106424 | Device for Determining the State of a Biological Subject - The invention relates to physics and can be used for determining the functional state of a biological object, for example, a human or an animal. | 04-29-2010 |
20100106425 | SOLID-STATE UREA BIOSENSOR AND ITS DATA ACQUISITION SYSTEM - A data acquisition system for a solid-state urea biosensor uses an amplifier, a low-pass filter and a data acquisition card to acquire and relay data to a computer to be analyzed by a signal analysis program and displayed on a display panel. The biosensor includes a substrate, and three individual sensing areas separated by an insulating layer on the substrate. Each individual sensing area contains a conductive layer on the substrate, and a pH sensitive membrane is deposited thereon. An enzyme layer is deposited on one of the pH sensitive membranes to form a working electrode. The other two sensing areas are a quasi-reference electrode and a contrast electrode, respectively. The signals are transferred to an instrumentation amplifier. The amplified signals are then transferred to a low-pass filter. The filtered signals are analyzed by the program and then displayed on the display panel. | 04-29-2010 |
20100106426 | REGIONS OF INTEREST PROCESSING - After prepared biological samples have been submitted to liquid-chromatography/mass spectrometry equipment, digital images are produced that show variations. Some of these variations may be of interest while others are not of interest. Variations in regions of interest can be correlated and correlation scores produced to classify biological features aid in scientific discovery. Shape properties of variations can also be calculated by geometric scores. A microalignment method aids the correlation calculation without resorting to macroalignment. | 04-29-2010 |
20100106427 | SAMPLE ANALYZER - A sample analyzer comprising: a sample preparing section for preparing first and second measurement sample including reagent and sample; a first detector for detecting a predetermined component in the first measurement sample prepared by the sample preparing section; a second detector for detecting the predetermined component in the second measurement sample prepared by the sample preparing section; and a controller configured for performing operations, comprising: (a) controlling the first detector to detect the predetermined component in the first measurement sample prepared by the sample preparing section; (b) determining the reliability of the result detected by the first detector; (c) controlling the sample preparing section to prepare the second measurement sample from the same sample when the result has been determined to be unreliable; and (d) controlling the second detector to detect the predetermined component in the second measurement sample, is disclosed. | 04-29-2010 |
20100114496 | Compositions and methods for surface abrasion with frozen particles - Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue. | 05-06-2010 |
20100114497 | Compositions and methods for therapeutic delivery with frozen particles - Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue. | 05-06-2010 |
20100114498 | METHOD FOR DETERMINING ISOTOPIC CLUSTERS AND MONOISOTOPIC MASSES OF POLYPEPTIDES ON MASS SPECTRA OF COMPLEX POLYPEPTIDE MIXTURES AND COMPUTER-READABLE MEDIUM THEREOF - Disclosed herein is a method of finding an isotopic cluster in a polypeptide and determining the monoisotopic mass of the cluster. The method comprises an algorithm for finding an isotopic cluster based on a probabilistic model, defined by each of peaks in the isotopic cluster, and determining the monoisotopic mass of the isotopic cluster. The probabilistic model of the isotopic cluster includes characteristic functions for mass, that is, a function of the ratio of two peak intensities, and a function of the product of two ratios obtained from three peaks. These characteristic functions for mass define the shape of peaks acceptable in an actual isotopic cluster for the mass of any isotopic cluster. The algorithm of finding the isotopic cluster based on the functions uses the characteristics to score the degree of the approximation of any isotopic cluster to the spectral shape of a theoretical cluster. First, peaks that can be included in the same isotopic cluster at a distance of 1 Da are found, and then the score is calculated in consideration of, whether the ratio and the product of ratios of peak intensities falls in the range of the previously defined maximum and minimum values of the characteristic functions, and the similarity to the average value. Accordingly, each of isotopic clusters can be determined, and finally, isotopic clusters having an overlapping peak are removed such that each peak is included only in one isotopic cluster, and the monoisotopic mass of each isotopic cluster is determined. | 05-06-2010 |
20100114499 | SYSTEM AND METHOD FOR PROCESSING RAW ACTIVITY ENERGY EXPENDITURE DATA - According to one embodiment, a method is provided for calculating, by an activity monitor comprising one accelerometer, a raw activity energy expenditure data based on movement by a user. The method includes determining if the raw activity energy expenditure data is associated with a high intensity physical activity, wherein the high intensity physical activity causes the raw activity energy expenditure data to differ from an expected activity energy expenditure data. The method includes calculating a corrected activity energy expenditure data, if the raw activity energy expenditure data is associated with the high intensity physical activity, based on the raw activity energy expenditure data, wherein the corrected activity energy expenditure data is substantially identical to the expected activity energy expenditure data. | 05-06-2010 |
20100114500 | ANALYSIS OF DNA - The invention provides methods for providing information on the probability of DNA samples being contaminated over days, weeks and months in relation to collection, processing and analysis of DNA samples. Methods are also provided for analysing the likelihood of a result arising due to contamination and/or determining the analysis protocol to be applied to a DNA sample and/or methods of operating databases, particularly containing DNA profiles. | 05-06-2010 |
20100121581 | Administering a therapeutic agent with more than one taggant - A system may include a means for administering a therapeutic agent to a subject; a means for administering a first pharmaceutically-acceptable taggant to the subject at least substantially concurrent with the therapeutic agent, the first pharmaceutically-acceptable taggant having a pharmacokinetic profile; and a means for administering a second pharmaceutically-acceptable taggant to the subject with the first pharmaceutically-acceptable taggant, the second pharmaceutically-acceptable taggant having a pharmacokinetic profile different from the pharmacokinetic profile of the first pharmaceutically-acceptable taggant. | 05-13-2010 |
20100125416 | Blood Based Methods for Assessing Adolescent Depression in a Subject - The present invention provides blood based methods for assessing adolescent depression in a subject. | 05-20-2010 |
20100125417 | Food content detector - A system may include utensil means for portioning a foodstuff into a first portion and a second portion, a means for detecting a first portion size for the first portion with the utensil means, a means for detecting a second portion size for the second portion with the utensil means, and a means for determining a cumulative amount of portioned foodstuff based upon the first portion size and the second portion size. | 05-20-2010 |
20100125418 | Food content detector - A system may include utensil means for portioning a foodstuff into a first portion and a second portion, a means for detecting a first portion size for the first portion with the utensil means, a means for detecting a second portion size for the second portion with the utensil means, and a means for determining a cumulative amount of portioned foodstuff based upon the first portion size and the second portion size. | 05-20-2010 |
20100125419 | Food content detector - A system may include utensil means for portioning a foodstuff into a first portion and a second portion, a means for detecting a first portion size for the first portion with the utensil means, a means for detecting a second portion size for the second portion with the utensil means, and a means for determining a cumulative amount of portioned foodstuff based upon the first portion size and the second portion size. | 05-20-2010 |
20100125420 | Food content detector - A system may include utensil means for portioning a foodstuff into a first portion and a second portion, a means for detecting a first portion size for the first portion with the utensil means, a means for detecting a second portion size for the second portion with the utensil means, and a means for determining a cumulative amount of portioned foodstuff based upon the first portion size and the second portion size. | 05-20-2010 |
20100138160 | Model transition sensitivity analysis system and method - A method and system for analyzing an infectious disease uses computer based simulation engines. The method and system utilizes at least two computer-based simulation engines of the transmission of the infectious disease. The transmission of the infectious disease is analyzed as a function of the first and second computer-based simulation engines. | 06-03-2010 |
20100138161 | METHOD AND SYSTEM FOR ANALYZING DRUG ADVERSE EFFECTS - The system of the present invention for assessing and analyzing the risks of adverse effects resulting from the use of at least one substance of interest, comprises a selector for identifying at least one substance of interest; a profiler for selecting from multiple profiles related to the safety of the at least one substance of interest, using at least one filter; at least one data mining engine; and an output device for displaying the analytic results from the data mining engine. Preferably, the at least one data mining engine is selected from (1) a proportional analysis engine to assess deviations in a set of the reactions to the drug of interest; (2) a comparator to measure the reactions to the drug of interest against a user-defined backdrop, and (3) a correlator to look for correlated signal characteristics in drug/reaction/demographic information; and an output device whereby a user can receive analytic results from the selector, the proportional analysis engine, the comparator, and the correlator. | 06-03-2010 |
20100138162 | NUCLEIC ACID SEQUENCING SYSTEM AND METHOD USING A SUBSET OF SITES OF A SUBSTRATE - A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected. | 06-03-2010 |
20100138163 | METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR MONITORED APPLICATION OF MECHANICAL FORCE TO SAMPLES USING ACOUSTIC ENERGY AND MECHANICAL PARAMETER VALUE EXTRACTION USING MECHANICAL RESPONSE MODELS - The subject matter described herein includes methods, systems, and computer readable media for monitored application of mechanical force to samples using acoustic energy and mechanical parameter value extraction using mechanical response models. One aspect of the subject matter described herein includes a method for determining mechanical property parameters of a sample. The method includes applying acoustic energy to a sample to apply a mechanical force to the sample. The method further includes measuring a response by the sample during the application of the acoustic energy to determine a value for a first mechanical property parameter of the sample. The method further includes measuring a recovery response of the sample following cessation of the application of the acoustic energy to determine a value for at least one second mechanical property parameter of the sample. The method further includes determining a value for at least one additional mechanical property parameter of the sample based on a mathematical relationship between the first, at least one second, and at least one additional mechanical property parameter. | 06-03-2010 |
20100138164 | PHYSICAL GEOLOCATION SYSTEM - A real-time system for determining the geographic movements of an individual or object by sampling particulates contained thereon. The system includes particle collection, sample preparations, and sample analysis using three primary modes of detecting certain particulates. The first mode involves the imaging of pollen, spores, or other biological material which are visible through a light microscope when properly stained or prepared. The second mode involves the use of real-time polymerase chain reaction to amplify and detect target nucleic acid sequences. The third mode involves the use of X-ray diffraction to identify mineral particles. The results from any mode, or any combination of modes, are analyzed by comparison to a reference database containing geographic information and the results are compiled by a controller for visual display. | 06-03-2010 |
20100145623 | Methods and systems for using ultraviolet index data in plant evaluation applications - Methods and systems for using UVI data in plant evaluation applications avail themselves of the correlation between PAR and UVI to estimate PAR based on UVI and apply the PAR estimate in a plant evaluation application, such as a plant selection or plant heath diagnostics application. A UVI-based PAR estimate may be used, for example, to dramatically reduce the time that an environmental probe must be deployed at a plant site by normalizing a sensor-based PAR estimate generated from short-term measurements taken by the environmental probe to produce a faster, more accurate and more reliable plant evaluation. | 06-10-2010 |
20100145624 | STATISTICAL VALIDATION OF CANDIDATE GENES - Provided herein are methods for evaluating associations between candidate markers and a trait of interest in a plant population. In various embodiments, the plant population is a breeding population, particularly early stage breeding populations. The methods include obtaining a genotypic value for candidate markers and correlating the marker with the trait. Various association models can be used to evaluate the association, and include statistical methods relevant to the structure of plant breeding populations. Population structure may be accounted for in the association models by using Principle Component Analysis. Further provided is a novel statistical approach for association mapping in early stage breeding materials using a transmission disequilibrium based methodology. Markers identified using the methods of the invention can be used in marker assisted breeding and selection, for constructing genetic linkage maps, to identify genes contributing to a trait of interest, and for generating transgenic plants having a desired trait. | 06-10-2010 |
20100145625 | DETERMINATION AND PREDICTION OF THE EXPRESSION OF TRAITS OF PLANTS FROM THE METABOLITE PROFILE AS A BIOMARKER - The present invention relates to a method for determining the correlation between the metabolite profiles (MPs) and the expression or potential for expression of a trait of a group of plants, and further to a method for determining or predicting the expression of a trait of a plant by taking advantage of the determined MP of said plant and a determined correlation between the MPs and the expression or potential for the expression of said trait in a group of plants. | 06-10-2010 |
20100145626 | Systems for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy - The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases. | 06-10-2010 |
20100145627 | SYSTEM WITH EXTENDED RANGE OF MOLECULAR SENSING THROUGH INTEGRATED MULTI-MODAL DATA ACQUISITION - A multi-modal data acquisition system for detecting target material on a biological reaction surface, the system comprising a radiation source for generating an incoming beam that impinges on the biological reaction surface at an oblique incidence angle and produces a reflected beam, an interferometric detector for detecting an interferometric signal from the illuminated surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated surface; the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam; and a processing system for receiving the interferometric and fluorescence signals and determining the presence or absence of target material on the biological reaction surface. A reaction surface conditioned for the simultaneous collection of fluorescence, interferometric and other signals. A multi-modal data acquisition system for collecting and processing additional modes, including multiple interferometric, fluorescence and scattering channels. | 06-10-2010 |
20100153016 | Diagnostic system for selecting nutrition and pharmacological products for animals - An analysis of the profile of a non-human animal comprises: a) providing a genotypic database to the species of the non-human animal subject or a selected group of the species; b) obtaining animal data; c) correlating the database of a) with the data of b) to determine a relationship between the database of a) and the data of b); c) determining the profile of the animal based on the correlating step; and d) determining a genetic profile based on the molecular dietary signature, the molecular dietary signature being a variation of expression of a set of genes which may differ for the genotype of each animal or a group of animals Nutrition and pharmalogical assessments are made. Reporting the determination is by the Intemet, and payment for the report is obtained through the Internet. | 06-17-2010 |
20100153017 | Methods and Workflows for Selecting Genetic Markers Utilizing Software Tool - A visual tool facilitates selecting SNPs for genotyping experiments comprises a first memory containing a datastore of pre-calculated linkage disequilibrium map information; a second memory containing a datastore of haplotype block information; and a third memory containing at least one set of tagging SNPs. A graphical user interface provides visualization of SNPs, integrated with a physical genome map. A stepwise selection tool associated with the graphical user interface facilitates selection of tagging SNPs by selectively using the information in at least one of the first, second and third memories. | 06-17-2010 |
20100153018 | Method for Identifying Genetic Determinants of Transcription Factor Activity - The disclosed subject matter is directed to genetic linkage methods for identifying genetic determinants of transcription factor activity. An inferred transcription factor activity profile is generated based on a nucleotide sequence-specific mathematical model of gene expression regulation. Genetic linkage analysis is performed to identify at least one genetic determinant linked to a specific transcription factor segregant based on the inferred transcription factor profile. | 06-17-2010 |
20100153019 | LEAST-SQUARE DECONVOLUTION (LSD): A METHOD TO RESOLVE DNA MIXTURES - Least Square Deconvolution (LSD) uses quantitative allele peak data derived obtained from a sample containing the DNA of more than one contributor to resolve the best-fit genotype profile of each contributor. The resolution is based on finding the least square fit of the mass ratio coefficients at each locus to come closest to the quantitative allele peak data. Consistent top-ranked mass ratio combinations from each locus can be pooled to form at least one composite DNA profile at a subset of the available loci. The top-ranked DNA profiles can be used to check against the profile of a suspect or be used to search for a matching profile in a DNA database. | 06-17-2010 |
20100153020 | DISULPHIDE BOND CONNECTIVITY IN PROTEIN - A method, computer system, and computer program product for determining N disulphide bond connections in a protein having 2N bonded sulphur atoms. Each sulphur atom is available for forming the N disulphide bond connections through use of an undirected graph having the 2N sulphur atoms as nodes and having an edge connecting each pair of nodes. Each sulphur atom is comprised by a cysteine of the protein. The cysteines are sequenced along a chain in the protein as ordered list of position indexes. A weight W of each edge between cysteine position indexes I | 06-17-2010 |
20100161236 | Pattern Recognition and Filtering in a Therapy Management System - A method of diabetes analysis includes receiving a plurality of glucose level readings for a user. A common event occurrence in at least two of the glucose level readings is determined. The at least two glucose level readings from the common event occurrence onwards in time for a time period is analyzed. A glucose level pattern formed by the at least two glucose level readings having a similar shape is determined. At least one anomalous glucose level reading having the similar shape and not conforming to the glucose level pattern is analyzed. The at least one anomalous glucose level reading is adapted to the pattern to form an adapted glucose level pattern. An insulin dosage for the time period beginning at the common event occurrence is calculated based on the adapted glucose level pattern. | 06-24-2010 |
20100161237 | Method and System for Genotyping Samples in a Normalized Allelic Space - Aspects of the present invention describe an apparatus and method for generating genotype calls for a sample. The genotyping initially models allelic signal response into an allelic model having one or more model parameters for an identified one or more sources of systematic variation. The model and parameters are then used to transform the allelic signals to a normalized normalized allelic space that serves to compensate for the one or more sources of systematic variation. By compensating for the systematic variation in this manner, the genotype for the sample is readily determined based upon its relationship to the representation of the allelic signals in normalized allelic space and in accordance with the allelic model. | 06-24-2010 |
20100161238 | Method and System for Detecting Peptide Peaks in HPLC-MS Signals - The present invention relates to a method, a computer tool and a system for detecting peptide peaks in measurement signals ( | 06-24-2010 |
20100161239 | QUANTITATIVE PREDICTION METHOD - The present invention concerns methods and systems for analysis of drug resistance in HIV-1. More specifically, the invention provides methods for predicting drug resistance by correlating genotypic information with phenotypic profiles. The methods allow the identification of primary and secondary resistance-associated mutations for new and existing drugs and for calculating the contribution of mutations and combinations of mutations to resistance and hyper-susceptibility. The invention allows the design, optimization and assessment of the efficiency of a therapeutic regimen based upon the genotype of the disease affecting a patient | 06-24-2010 |
20100169022 | Computational methods and systems for treatment in relation to modulation of CYP450 enzyme activity - Methods and systems such as those described herein include accepting input, identifying CYP450-family enzymes, identifying at least one modulator of an enzyme, and communicating one or more treatments to a system user. | 07-01-2010 |
20100169023 | Computational methods and systems for suggesting modulators of CYP450 as treatment options - Computational methods and systems are described which accept input, identify one or more CYP450-family enzymes, identify one or more modulators of the CYP450-family enzymes, and communicate treatments to at least one system user, wherein the treatments include one or more of the identified at least one modulator. | 07-01-2010 |
20100169024 | DEFINING QUANTITATIVE SIGNATURES FOR DIFFERENT GLEASON GRADES OF PROSTATE CANCER USING MAGNETIC RESONANCE SPECTROSCOPY - A method for classifying a possible cancer from a magnetic resonance spectrographic (MRS) dataset includes extracting at least one feature from the MRS dataset as being identified with the possible cancer and embedding the extracted feature into a low dimensional space to form an embedded space. The method then clusters the embedded space into clusters representing a plurality of predetermined classes and spectrally decomposing the clusters to identify substantially significant independent metabolic signatures. The method then classifies the possible cancer as belong to one of at least two cancer classes based on the identified independent metabolic signatures. | 07-01-2010 |
20100169025 | METHODS AND GENE EXPRESSION SIGNATURE FOR WNT/B-CATENIN SIGNALING PATHWAY - Methods, biomarkers, and expression signatures are disclosed for assessing the regulation status of Wnt/β-catenin signaling pathway in a cell sample or subject. More specifically, several aspects of the invention provide a set of genes which can be used as biomarkers and gene signatures for evaluating Wnt/β-catenin pathway deregulation status in a sample; classifying a cell sample as having a deregulated or regulated Wnt/β-catenin signaling pathway; determining whether an agent modulates the Wnt/β-catenin signaling pathway in sample; predicting response of a subject to an agent that modulates the Wnt/β-catenin signaling pathway; assigning treatment to a subject; and evaluating the pharmacodynamic effects of therapies designed to regulate Wnt/β-catenin pathway signaling. | 07-01-2010 |
20100174491 | METHODS OF MEASURING CONCENTRATION OF COMPONENT IN BIOCHEMICAL SAMPLE AND ESTIMATING RELIABILITY OF TEST RESULT - Provided are a method of measuring a concentration of a component in a biochemical sample such as serum, and a method of estimating the reliability of a test result using the method. The method of measuring a concentration of a component includes: preparing plural standard samples having at least one common component which has varying concentrations; measuring absorbances of the component in the standard samples at each of the concentrations for plural light beams having different wavelength bands; determining a regression equation of a relationship between the concentration of the component and the measured absorbances at plural wavelength bands; and applying the regression equation by measuring absorbances at the plural wavelength bands of the biochemical sample and applying the measured plural absorbances of the biochemical sample to the regression equation to calculate the concentration of the component. | 07-08-2010 |
20100174492 | Method and system for determining whether a drug will be effective on a patient with a disease - A process of determining whether a patient with a disease or disorder will be responsive to a drug, used to treat the disease or disorder, including obtaining a test spectrum produced by a mass spectrometer from a serum produced from the patient. The test spectrum may be processed to determine a relation to a group of class labeled spectra produced from respective serum from other patients having the or similar clinical stage same disease or disorder and known to have responded or not responded to the drug. Based on the relation of the test spectrum to the group of class labeled spectra, a determination may be made as to whether the patient will be responsive to the drug. | 07-08-2010 |
20100174493 | Systems for genome selection - Systems, methods, compositions and apparatus relating to genome selection are disclosed. | 07-08-2010 |
20100179763 | DETECTION OF COUPLED RF CURRENT MRI BODIES - A method for detecting coupled RF current magnetic resonance (MR) objects in a body and determining MR risk is provided. The body is scanned with reverse circularly polarized RF. MR signals generated by coupling of the reverse circularly polarized RF with the RF current MR objects are detected. The detected MR signals are used to determine a risk value. | 07-15-2010 |
20100179764 | METHOD, APPARATUS, AND PROGRAM FOR EVALUATING DRIVABILITY OF A VEHICLE - A time series myoelectric potential signal is acquired, which is representative of time series activity amount of a muscle of a driver when the driver is performing a driving operation on the vehicle, the muscle being involved in the driving operation. Based on the acquired time series myoelectric potential signal, a parameter value indicative of a fluctuation amount of the time-series myoelectric potential signal and an average value of the myoelectric potential signal are obtained. Drivability of the vehicle is evaluated based on the obtained parameter value and the obtained average value. | 07-15-2010 |
20100179765 | Novel Methods and Devices for Evaluating Poisons - Methods and devices useful for evaluating poisons or other chemical entities, and for using such methods to forecast unfavorable drug effects. | 07-15-2010 |
20100179766 | Method for Identifying Peptides Using Tandem Mass Spectra by Dynamically Determining the Number of Peptide Reconstructions Required - A method for identifying peptides using tandem mass spectrometry takes the spectrum for a peptide to be analyzed and uses a scoring function to score a match between the spectrum and each candidate peptide in a peptide database. The scoring function has a value corresponding to a number of fragment peaks in the spectrum that match fragment peaks in a spectrum of the candidate peptide. Using the match scores, a generating function of the spectrum is computed to determine the number of peptide reconstructions at each value of the scoring function. The generating function is then used to determine the number of candidate peptides for each match score and the probability of a peptide having a given match score to the spectrum. A spectral probability can be determined by calculating the total probability of all peptides with scores equal to or larger than the given match score. | 07-15-2010 |
20100179767 | PORTABLE PLANT HEIGHT AND EAR HEIGHT MEASURING DEVICE - A method and apparatus for dimensionally characterizing a target structure. In an example of the apparatus, the apparatus has a pole having a bottom end and a top end, an indicator system adapted to apprise an operator of the position of a dimension determination system relative to the target structure, and a measurement system adapted to apprise the operator of a dimension of one or more features of the target structure. In another example, the method includes taking a pole having a bottom and top end with a height determination system, a height indicator system and a height measurement system, orienting the pole relative to the plant structure, raising the height determination system to the height of the target plant structure, and determining the height of the target plant structure. | 07-15-2010 |
20100179768 | Method, System and Computer Simulation Environment for Testing of Monitoring and Control Strategies in Diabetes - A simulation environment for in silico testing of monitoring methods, open-loop and closed-loop treatment strategies in type 1 diabetes. Some exemplary principal components of the simulation environment comprise, but not limited thereto, the following: 1) a “population” of in silico “subjects” with type 1 diabetes in three age groups; 2) a simulator of CGM sensor errors; 3) a simulator of insulin pumps and discrete insulin delivery; 4) an interface allowing the input of user-specified treatment scenarios; and 5) a set of standardized outcome measures and graphs evaluating the quality of the tested treatment strategies. These components can be used separately or in combination for the preclinical evaluation of open-loop or closed-loop control treatments of diabetes. | 07-15-2010 |
20100185397 | METHOD FOR IDENTIFYING NUCLEOTIDE SEQUENCE, METHOD FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE, APPARATUS FOR IDENTIFYING NUCLEOTIDE SEQUENCE, APPARATUS FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE, PROGRAM FOR IDENTIFYING NUCLEOTIDE SEQUENCE, AND PROGRAM FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE - It is intended to provide a method for identifying a nucleotide sequence necessary for expressing an affinity for a target substance in nucleotide sequences of nucleic acid molecules such as aptamers having the affinity for the target substance based on a homology of the respective nucleotide sequences and an evaluation value related to the affinity of the nucleotide sequences, and a method for predicting a secondary structure of a nucleic acid molecule containing the identified nucleotide sequence. The method for identifying a nucleotide sequence necessary for expressing an affinity for a target substance in nucleotide sequences of nucleic acid molecules having such an affinity is characterized by comprising the steps of: extracting a single-strand region from the nucleotide sequences of nucleic acid molecules by excluding nucleotides capable of forming a stem structure; and searching a motif sequence based on an evaluation value of the affinity from the single-strand region. | 07-22-2010 |
20100185398 | System and Method for Monitoring Athletic Performance - A system for monitoring biometric data of an athlete participating in a sporting event comprises at least one biometric sensor carried by the athlete. The sensor senses biometric data for the athlete and delivers the data to a transmitter located on the athlete. The transmitter automatically transmits the biometric data to a wireless telephony network as the athlete participates in the sporting event. The wireless telephony network, in turn, delivers the biometric data to a processing server via the Internet. The processing server receives the biometric data and transforms the data into processed biometric data for the athlete. The processed biometric data for the sporting event is available to the athlete or other authorized individuals in real time and/or any time following the sporting event at a computer connected to the Internet. | 07-22-2010 |
20100185399 | Method for Analyzing Clinical Trial Results for Efficacy of a Therapy - Methods of identifying, monitoring and matching patients with appropriate treatments who are at risk for developing a systemic inflammatory condition using a systemic mediator-associated physiologic test profile are provided. The methods of the present invention increase the likelihood of demonstrating clinical efficacy in clinical trial datasets. | 07-22-2010 |
20100185400 | COMPUTER PRODUCT, ANALYSIS SUPPORT APPARATUS, AND ANALYSIS SUPPORT METHOD - A non-transitory computer-readable recording medium stores therein an analysis support program causing a computer to execute receiving test result data identifying an analysis subject molecule, and quantity-changing molecules that have changed in quantity due to administration or deficiency of the analysis subject molecule in a test subject; acquiring a first pathway indicating an interaction between the quantity-changing molecules identified by the test result data and a second pathway indicating a molecular interaction with the analysis subject molecule, from a database storing therein for each molecular interaction, a type; determining from among biological phenomena correlated with the interaction between quantity-changing molecules of the first pathway, determines a biological phenomenon other than a biological phenomenon correlated with a molecular interaction of the second pathway to be a novel biological phenomenon caused by administration or deficiency of the analysis subject molecule; and outputting a determination result obtained at the determining. | 07-22-2010 |
20100191472 | Method and Device for Early Signal Attenuation Using Blood Glucose Measurements - Methods and devices to detect analyte in body fluid are provided. Embodiments include receiving one or more analyte sensor data, receiving a reference measurement value associated with an analyte level, determining a sensitivity parameter based on the received one or more analyte sensor data and the reference measurement value, performing a probability analysis based on prior analyte sensor data to determine presence of signal attenuation, and generating an output value based on the probability analysis. | 07-29-2010 |
20100191473 | Apparatus, method, and computer program product for determining gene function and functional groups using chromosomal distribution patterns - A method, apparatus, and computer program product for analyzing gene expressions is presented. An operation is performed for determining a gene expression pattern for a condition, wherein the gene expression pattern comprises a gene expression. Next, a spatial-expression pattern is formed by selecting a chromosomal region having an exon; and associating the gene expression within the gene expression pattern with its corresponding exon. A further operation may be performed, where in the forming of the spatial-expression pattern, a spatial-expression pattern signal is created as a representation of the spatial-expression pattern. The magnitude of the spatial-expression pattern signal at any point is determined by an expression level of the corresponding exon. Spatial patterns may be identified in the signal by means of various signal processing techniques such as Fourier or Wavelet transforms. Also, multiple regions and/or conditions may be tested and their reaction patterns compared to determine related genetic regions. | 07-29-2010 |
20100191474 | ELECTRONIC NOSE DEVICE WITH SENSORS COMPOSED OF NANOWIRES OF COLUMNAR DISCOTIC LIQUID CRYSTALS WITH LOW SENSITITIVE TO HUMIDITY - Electronic nose device having a plurality of sensors composed of nanowires of columnar discotic liquid crystals, the device having low sensitivity to humidity. The device is designed to determine the composition and concentration of volatile organic compounds in a sample with very high sensitivity. Methods for use of the device in applications such as diagnosis of disease and food quality control are disclosed. | 07-29-2010 |
20100191475 | METHOD FOR IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF AGENTS WHICH MODULATE ION CHANNEL ACTIVITY - Materials, methods and a computer system are provided which facilitate the identification and characterization of modulators of potassium ion channels, particularly the HERG channel. | 07-29-2010 |
20100191476 | BIOLOGICAL SAMPLE PROCESSING APPARATUS THAT SELECTS THE PERSONALITY TYPE OF THE APPARATUS - A biological sample processing apparatus having a central processing unit, a display in communication with the central processing unit and a selector for selecting a personality type of the apparatus, the selector being in communication with the central processing apparatus. The selection of a personality type prompts the central processing unit to cause the display to show a list of preprogrammed protocols for biological sample processing that correspond to the selected personality type. | 07-29-2010 |
20100198520 | Method, System and Computer Program Product for Evaluation of Insulin Sensitivity, Insulin/Carbohydrate Ratio, and Insulin Correction Factors in Diabetes from Self-Monitoring Data - A method, system and computer program product for evaluating or determining a user's insulin sensitivity (SI). An initial step or module may include acquiring SMBG readings from a predetermined period. Another step or module may include computing an estimate of insulin sensitivity (SI) from the SMBG readings. Another step or module may include using the estimate of SI to compute individualized carbohydrate ratio. Additionally, another step or module may include using the estimate of SI to compute individualized correction factor. The computation of the two components of an insulin dose calculator, carbohydrate ratio and correction factor, uses this estimate, which allows the tailoring of carbohydrate ratio and correction factor to the present state of the person. | 08-05-2010 |
20100198521 | CHEMICALLY SENSITIVE FIELD EFFECT TRANSISTORS AND USES THEREOF IN ELECTRONIC NOSE DEVICES - The present invention provides an electronic nose device based on chemically sensitive field effect transistors. In particular, the sensors of the electronic nose device are composed of non-oxidized, functionalized silicon nanowires which can detect volatile organic compounds with very high sensitivity. Methods of use in diagnosing diseases including various types of cancer are disclosed. | 08-05-2010 |
20100198522 | Computer-Assisted Method of Analyzing a DNA Mixture - The present invention relates to a computer-assisted method of analyzing a DNA mixture having two or more individual contributors by use of STR technology. The method comprises the steps of obtaining, for a number of STR loci, observed peak area data vector and observed peak height data vector for each peak within a locus, and observed allele data informing which alleles are observed for each loci; and obtaining peak area model data for peak areas by use of a statistical model assuming a normal distribution for the peak areas and assuming conditional independence of the peak area vectors given the sums of the peak areas within each locus. A conditional mean vector and a conditional covariance matrix is proposed and used for the statistical model. The invention also proposes a method for determining, for each locus of the STR loci and by use of the proposed statistical model, a best matching combination of variables indicating the number of allele copies from each individual contributor to the mixture and thereby specifying the DNA mixture. | 08-05-2010 |
20100204920 | SYSTEM FOR DEVELOPMENT OF INDIVIDUALISED TREATMENT REGIMENS - A system is provided for facilitating the development of an individualised treatment regimen for a patient based on an evaluation of the risk(s) associated with a disease and/or associated with known treatment options. In order to evaluate these risk(s), the system utilises clinical data from a plurality of patients having the disease in question. The clinical data includes information for each of the plurality of patients relating to the presence, absence and/or severity of one or more negative events. The negative event(s) can be disease-related, for example, a complication such as metastasis of a cancer to bone or the brain, or the negative event(s) can be treatment-related, for example a toxicity associated with the treatment. The system can also include prediction models that allow the probability that a patient will develop a toxicity or complication to be assessed. Methods for developing prediction models are provided. | 08-12-2010 |
20100204921 | METHOD FOR SELECTING STATISTICALLY VALIDATED CANDIDATE GENES - Provided herein are methods for evaluating associations between candidate genes and a trait of interest in a population. The methods include a combination of genome-wide association analysis and one or more of nested association mapping (NAM), expression QTL analysis (eQTL), and allele epistastic analysis (AEA). Markers are selected or prioritized if they are shown to be positively-correlated with a trait of interest using GWA and a combination of one or both of NAM and eQTL. Also provided are models for evaluating the association between a candidate marker and a trait in a nested population of organisms. These methods include single marker regression and multiple marker regression models. Markers identified using the methods of the invention can be used in marker assisted breeding and selection, as genetic markers for constructing linkage maps, for gene discovery, for identifying genes contributing to a trait of interest, and for generating transgenic organisms having a desired trait. | 08-12-2010 |
20100204922 | METHOD AND APPARATUS FOR SELECTING PHARMACOGENOMIC MARKERS - Provided are a method and apparatus for selecting pharmacogenomic markers. The method includes calculating evaluation indexes for evaluating the degree of association between genetic markers of genes associated with at least one drug and the drug, and selecting some of the genetic markers based on the calculated evaluation indexes. | 08-12-2010 |
20100204923 | Comparing Accuracies Of Lie Detection Methods - A method for selecting the most accurate lie detection method from a group of methods, the method includes the steps of: (a) collecting the results from different methods of conducting lie detection tests; (b) plotting the results on a polar graph; c) computing the “random chance” point on the graph for each method's results; (d) fitting a quadratic curve to the defined points for each method; (e) computing the area beneath each method's curve; (f) mapping the area to a log-base-2 score; and (g) choosing as the most accurate method the method with a higher log-base-2 score. | 08-12-2010 |
20100211325 | LAMININ BINDING SITE - The present invention in one aspect related to a ligand binding site for laminin, particularly those laminins comprising an α5 chain. The invention also encompasses binding sites on Lutheran glycoprotein (“Lu gp”) for binding laminin (“LM”) isoforms containing an α5 chain, mutant Lu gp molecules impaired at this binding site, antagonists and enhancers of the site, methods for identifying antagonists and enhancers, and uses of these molecules. | 08-19-2010 |
20100211326 | ELECTRONIC HYBRIDIZATION ASSAY AND SEQUENCE ANALYSIS - An electronic hybridization assay implements a hybridization reaction, or a sequence analysis, on sequences representative of the sequences of the molecules under examination to provide an output representative of a chemical hybridization reaction. An electronic hybridization machine implements a correlation algorithm where the correlation output provides information regarding the relationship between the molecules under examination. In one aspect, the degree of similarity between the molecules is indicated by the correlation output value. In another aspect, a locus of similarity between the molecules is indicated by a maximum value in the correlation output sequence. In a particular aspect, the sequences are encoded in an optimized format to optimize the operation of the operation of the electronic hybridization machine. | 08-19-2010 |
20100211327 | Methods and Systems for Viral Diagnosis - Methods, apparatus, and software for identifying sets of genomic oligonucleotides that identify a viral family and for determining sets of probes and primers that can be used to identify members of viral families in a sample are provided. In one embodiment, the method of the present invention includes normalizing viral genomic oligonucleotide sequence data from at least one viral family, and identifying at least one oligonucleotide sequence that is unique to each viral family. An array of the identified oligonucleotide sequences is made. Primers provided by the present invention are used to amplify viral family genomic sequences in a biological sample of interest, and probes provided using the present invention, e.g., attached to an array or biochip, are then used to detect the presence of the corresponding virus(es) present in the sample by hybridization. | 08-19-2010 |
20100217532 | SYSTEMS AND METHODS FOR IDENTIFYING STRUCTURALLY OR FUNCTIONALLY SIGNIFICANT AMINO ACID SEQUENCES - Methods and computer readable storage mediums for identifying structurally or functionally significant amino acid sequences encoded by a genome are disclosed. At least one structurally or functionally significant amino acid sequence encoded by a genome may be identified by compiling an observed frequency for each of a plurality of amino acid words encoded by the genome, calculating with a computer an expected frequency for each of the plurality of amino acid words encoded by the genome, and identifying at least one structurally or functionally significant amino acid sequence encoded by the genome based at least in part on the observed and expected frequencies for each of the plurality of amino acid words encoded by the genome. | 08-26-2010 |
20100217533 | Identifying a Type of Motion of an Object - A method of identifying a type of motion of an animate or inanimate object is disclosed. The method includes generating an acceleration signature based on the sensed acceleration of the object. The acceleration signature is matched with at least one of a plurality of stored acceleration signatures, wherein each stored acceleration signatures corresponds with type of motion. The type of motion of the object is identified based on the statistical matching or exact matching of the acceleration signature. | 08-26-2010 |
20100217534 | METHODS AND MATERIALS FOR CANINE BREED IDENTIFICATION - In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations. | 08-26-2010 |
20100223013 | TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. | 09-02-2010 |
20100228487 | Postural information system and method - For two or more devices, each device having one or more portions, a method includes, but is not limited to: obtaining physical status information regarding one or more portions for each of the two or more devices, including information regarding one or more spatial aspects of the one or more portions of the device, determining user advisory information regarding the one or more users based upon the physical status information for each of the two or more devices and based upon the user status information regarding the one or more users, and determining user advisory information regarding the one or more users based upon the physical status information for each of the two or more devices and based upon the user status information regarding the one or more users. In addition to the foregoing, other related method/system aspects are described in the claims, drawings, and text forming a part of the present disclosure. | 09-09-2010 |
20100228488 | Postural information system and method - For two or more devices, each device having one or more portions, a system includes, but is not limited to: one or more obtaining information modules configured to direct obtaining physical status information regarding one or more portions for each of the two or more devices, including information regarding one or more spatial aspects of the one or more portions of the device, one or more determining advisory modules configured to direct determining user advisory information regarding the one or more users based upon the physical status information for each of the two or more devices and based upon the user status information regarding the one or more users., and one or more determining advisory modules configured to direct determining user advisory information regarding the one or more users based upon the physical status information for each of the two or more devices and based upon the user status information regarding the one or more users. In addition to the foregoing, other related method/system aspects are described in the claims, drawings, and text forming a part of the present disclosure. | 09-09-2010 |
20100228489 | Postural information system and method - A system includes, but is not limited to, a obtaining information module configured for obtaining user advisory information including information regarding one or more users each of two or more devices based at least in part upon physical status information including information regarding one or more spatial aspects of one or more portions of each of the two or more devices, and an output module configured for outputting output information based at least in part upon one or more elements of the user advisory information. | 09-09-2010 |
20100228490 | Postural information system and method - A system includes, but is not limited to: one or more obtaining information modules configured for obtaining subject advisory information regarding one or more subjects of two or more postural influencers based at least in part upon postural aspects associated with the one or more subjects and spatial aspects associated with the two or more postural influencers, and one or more output modules configured for outputting output information based at least in part upon one or more elements of the subject advisory information. In addition to the foregoing, other related method/system aspects are described in the claims, drawings, and text forming a part of the present disclosure. | 09-09-2010 |
20100228491 | Cross-Instrument Method and System for Cell Population Discrimination - The present invention provides methods and systems to combine the capabilities of a hematology analyzer with those of a flow cytometer to yield a far more powerful analytical system than either device alone. In one embodiment, a method of analyzing a cell sample includes receiving a first data generated by an analysis of a first aliquot of the sample on a first particle analyzer having a fluorescence measurement device such as a flow cytometer, detecting at least one unresolved cell population in the first data, and accessing a second data stored on a storage device wherein the second data was previously generated by interrogating a second aliquot of the sample using at least one of a cell volume measurement device and a cell conductivity measurement device in a second particle analyzer such as a hematology analyzer. The unresolved cell population in the first data is then resolved using the second data. Corresponding system embodiments are also disclosed. | 09-09-2010 |
20100228492 | Postural information system and method including direction generation based on collection of subject advisory information - A method includes, but is not limited to: for each of one or more instances, determining subject advisory information regarding one or more subjects associated with the instance based at least in part upon postural influencer status information including information involving one or more spatial aspects for each of two or more postural influencers of the one or more subjects, and generating one or more directions based at least in part upon each of the subject advisory information associated with each of the more than one instances. In addition to the foregoing, other related method/system aspects are described in the claims, drawings, and text forming a part of the present disclosure. | 09-09-2010 |
20100228493 | Postural information system and method including direction generation based on collection of subject advisory information - A system includes, but is not limited to: for each one or more instances, determining subject advisory information regarding one or more subjects associated with the instance based at least in part upon postural influencer status information including information involving one or more spatial aspects for each of two or more postural influencers of the one or more subjects, and generating one or more directions based at least in part upon each of the subject advisory information associated with each of the more than one instances. In addition to the foregoing, other related method/system aspects are described in the claims, drawings, and text forming a part of the present disclosure. | 09-09-2010 |
20100228494 | Postural information system and method including determining subject advisory information based on prior determined subject advisory information - A method includes, but is not limited to: for each of one or more first instances, determining subject advisory information regarding one or more subjects associated with the first instance based at least in part upon postural influencer status information including information involving one or more spatial aspects for each of two or more postural influencers of the one or more subjects, and for a second instance, based at least in part upon each of the subject advisory information associated with each of the one or more first instances, generating subject advisory information regarding one or more subjects being associated with the second instance and being posturally influenced by two or more postural influencers. In addition to the foregoing, other related method/system aspects are described in the claims, drawings, and text forming a part of the present disclosure. | 09-09-2010 |
20100228495 | Postural information system and method including determining subject advisory information based on prior determined subject advisory information - A system includes, but is not limited to: one or more determining advisory modules configured for each of one or more first instances, determining subject advisory information regarding one or more subjects associated with the first instance based at least in part upon postural influencer status information including information involving one or more spatial aspects for each of two or more postural influencers of the one or more subjects, and one or more second determining modules configured for a second instance, based at least in part upon each of the subject advisory information associated with each of the one or more first instances, generating subject advisory information regarding one or more subjects being associated with the second instance and being posturally influenced by two or more postural influencers. In addition to the foregoing, other related method/system aspects are described in the claims, drawings, and text forming a part of the present disclosure. | 09-09-2010 |
20100228496 | Methods for the Determination of a Copy Number of a Genomic Sequence in a Biological Sample - Methods for the determination of a copy number of a target genomic sequence; either a target gene or genomic sequence of interest, in a biological sample are described. Various methods utilize a model drawn from a probability density function (PDF) for the assignment of a copy number of a target genomic sequence in a biological sample. Additionally, the methods provide for the determination of a confidence value for a copy number assigned to a sample based on attributes of the sample data. Accordingly, the various methods for the determination of a copy number provide the end user with significant information for the evaluation of a copy number of a target genomic sequence; either a gene or genomic sequence of interest. | 09-09-2010 |
20100228497 | TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. | 09-09-2010 |
20100235103 | Method and apparatus for evaluating prothrombotic conditions - Methods and apparatus are disclosed for determining a prothombotic condition, including a condition of hypercoagulability. The determination is based on the clotting of a sample of blood or blood components which involves reacting the sample with a clotting agent and recording time and absorbance values. A slope determination is utilized to determine an indicator for a prothrombotic condition. The indicator according to embodiments, may be determined through the derivation of an angle in conjunction with the clotting analysis and slope. | 09-16-2010 |
20100235104 | Methods for Classification of Toxic Agents and Counteragents - Methods and systems for evaluating biological dataset profiles relating to toxic agents including candidate pharmaceuticals, environmental agents, biowarfare and chemical warfare agents are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate agents. | 09-16-2010 |
20100235105 | METHOD FOR ANALYZING DYNAMIC DETECTABLE EVENTS AT THE SINGLE MOLECULE LEVEL - A method to be implemented on or in a computer is disclosed, where the method includes data collection, calibration, candidate selection, and analysis of data streams associated with each candidate to classify single molecule fluorescence resonance energy transfer events. Once classified, the classification can be related to the nature of the events, such as the identification of dNTP incorporation during primer extension to obtain a base read out of an unknown template. | 09-16-2010 |
20100235106 | SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms. | 09-16-2010 |
20100241357 | Single-Cell Raman Spectroscopy for the Non-Destructive, Non-Invasive Analysis of Cells and Cellular Components - Raman spectra of cells, such as normal human T- and B-cells from peripheral blood or human tonsil and the corresponding transformed cells are obtained by optically trapping the cells and obtaining their Raman spectra. The trapped cells can be subjected to one, two, or more different excitation wavelengths, and each wavelength of the corresponding Raman spectra can be stored in a separate channel. In preferred embodiments, two spectra are subtracted from each other to give a difference spectrum and each channel is analyzed independently to characterize the trapped cell. Alternatively, the Raman spectrum can be subjected to Principal Component Analysis (PCA) in order to characterize the trapped cell. The trapped cell thus classified can be sorted, or further manipulated. | 09-23-2010 |
20100241358 | ANALYSIS - A method of verifying the performance of a size standard, formed of a plurality of size standard elements, used in a nucleic acid analysis method is provided. The verification is achieved by introducing the size standard to an analysis stage and performing a size based separation on the size standard. The size based separation defines an experimental position for each size standard element. A comparison is made as to whether or not the experimental position for the size standard element corresponds with expected position. The comparison allows a decision to be made on whether or not to use the size standard, which is dependent upon whether or not the experimental position of the size standard element corresponds with the expected position. | 09-23-2010 |
20100241359 | ESTIMATION OF DIAGNOSTIC MARKERS - The invention relates to a method for estimating concentrations or concentration changes of particular biological markers, e.g. proteins. The estimations are performed by providing a mathematical model with data from measurements of other biological markers, e.g. other proteins. Thus, instead of measuring those particular proteins they can be estimated using the model. The estimated proteins can be used together with other clinical data in another model which is able to provide information or estimations of, for example, a patient's disease. | 09-23-2010 |
20100250143 | IDENTIFYING BIOLOGICAL RESPONSE PATHWAYS - A method for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response; accessing a database containing information characterizing molecular interactions; determining pathways connecting the identified molecules participating in the cellular response; and solving an optimization problem that includes determining a subset of the molecules and interactions having a minimum aggregate cost. The pathways include, nodes, each representing a molecule, and edges, each connecting a respective pair of nodes and representing an interaction between a respective pair of molecules represented by the respective pair of nodes. Nodes from a subset of nodes represent molecules identified as participating in the cellular response. | 09-30-2010 |
20100250144 | Method and System for Determining the Difference Between Pre-Prandial and Post-Prandial Blood Glucose Values - A method and system is disclosed that enables a less error-prone and preferably automatic assignment of pre-prandial and post-prandial blood glucose values associated with a meal to improve determining the difference between pre-prandial and post-prandial blood glucose measurements as follows. Blood glucose measurements are read and provided with a relative or absolute time mark and labeled as pre-prandial and reading out post-prandial blood glucose measurements provided with a relative or absolute time mark from the memory of a blood glucose measuring instrument. The chronological sequence of the blood glucose measurements labeled as pre-prandial are determined. The post-prandial blood glucose measurements that correspond to each of the pre-prandial blood glucose measurements are determined by applying a time selection criterion. The difference between corresponding pre-prandial and post-prandial blood glucose measurements is determined. The difference values are displayed that have improved diagnostic value. | 09-30-2010 |
20100250145 | SNP DETECTION BY MELT CURVE CLUSTERING - Systems, methods and apparatus for an automated analysis of a collection of melt curves is provided. The analysis can identify certain characteristics of double stranded nucleotide sequences (e.g. DNA or other nucleotide sequences) which were melted. For example, a variation (e.g. a mutation) in the sequences (also called amplicons) may be determined from the analysis. The amplicons may be amplified via any amplification mechanism, such as PCR or Ligase chain reaction (LCR). The automated analysis can include identifying a melt region, normalizing a melt curve, and clustering melt curves. | 09-30-2010 |
20100262374 | Systems and methods for analyzing nanoreporters - Methods, computers, and computer program products for detecting the presence of a probe within a sample overlayed on a substrate are provided. The probe comprises a plurality of spatially arranged labels. A data storage module stores a plurality of light images, where each light image has light from the sample at a corresponding wavelength range in a plurality of different wavelength ranges. A label identification module identifies a plurality of labels in the plurality of light images that are proximate to each other on the substrate. A spatial order of the plurality of labels determines a string sequence of the plurality of labels. A probe identification module determines whether the string sequence of the plurality of labels comprises a valid reporter sequence. | 10-14-2010 |
20100262375 | METHOD AND APPARATUS FOR FORMING A HOMEOSTATIC LOOP EMPLOYING AN APTAMER BIOSENSOR - A novel architecture solid-state biosensor for label-free detection of vascular endothelial growth factor (VEGF) hybridization is presented. The new device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. The detection mechanism is based on an electrochemical binding of circulating VEGF to an immobilized VEGF aptamer; whereby binding of these two compounds modulates the threshold voltage of a novel circuit, changing the impedance (capacitance) of the circuit. This novel circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the VEGF molecules and the aptamer. An apparatus forming a fluid cell is configured so as to enable the flow for delivering VEGF samples onto the active surface of the chip. The device has an array of parallel capacitors which act as an integrated, individual counter-electrode, computational apparatus which employs the sensory output over the time domain so as to enable detection, reporting and formation of a homeostatic loop for VEGF measurements. Moreover, this detector is able to provide an accurately measured and quantifiable rate of change of the VEGF molecules in-vivo, providing real time feedback of this important biomarker which may be used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden. | 10-14-2010 |
20100262376 | APPARATUS, METHOD AND PROGRAM FOR ANALYZING NUCLEIC ACID BASE SEQUENCE AND BASE MODIFICATION - Provided is an apparatus by which a nucleic acid may be analyzed quickly and precisely. Specifically, provided is an apparatus for analysis of a nucleic acid including: a processing unit for creating, based on a total base composition of a nucleic acid, a plurality of base composition sets, creating a hierarchical structure in which the base composition sets are hierarchized in ascending order of a number of bases in a partial base composition at a terminal position, and further creating connection relations between each of the base composition sets, and another base composition set having, at the terminal position, a partial base composition obtained by adding one base to a partial base composition at the terminal position of each of the base composition sets; a processing unit for calculating, for each of the partial base compositions, a predicted mass value of a corresponding product ion, and imparting a weight to each of the base composition sets based on a comparison between the predicted mass value and an actual mass value of a product ion derived from the nucleic acid; and a processing unit for selecting one of base composition sets belonging to each hierarchy while following the connection relations from an outermost hierarchy in the hierarchical structure, based on a weight imparted to each of the base composition sets, to thereby determine a base sequence sequentially from a terminal base of the nucleic acid. | 10-14-2010 |
20100262377 | EMG AND EEG SIGNAL SEPARATION METHOD AND APPARATUS - This invention consists of a method and apparatus for separation of the facial electromyogram (EMG) and the electroencephalogram (EEG) implemented in an index for assessing the level of consciousness during general anaesthesia. The surface EEG/EMG signal is collected from three electrodes ( | 10-14-2010 |
20100262378 | Cytological Analysis by Raman Spectroscopic Imaging - A method for generating an image of a sample that is informative of the disease state of a cell in the sample. A sample including the cell is irradiated with monochromatic light. The Raman scattered light is assessed. A digital brightfield image of the Raman scattered light is generated and combined with the Raman scattered light emitted by the cell whereby the Raman scattered light is informative of the disease state of the cell in the sample. The method can also be used to determine the metabolic activity of the cell, the inflammatory status of the cell and/or the infected status of the cell in the sample. | 10-14-2010 |
20100268472 | DETERMINATION OF SINGLE PEAK MELTING TEMPERATURE BY PCR ANALOGY AND DOUBLE SIGMOID EQUATION - Systems and methods for determining melting temperatures, Tm, for DNA from melt curve data. The systems and methods also allow for quantitative determination of gene amount based on peak height. A PCR analogy is used to perform quantization of an acquired melting curve dataset. The melting curve is transformed using a horizontal flip and a horizontal translation, and a double sigmoid equation is then fit to the data. Inverse translation and inverse horizontal flip transforms are applied to the equation to produce an equation based solution of the melt curve dataset. The equation based solution of the melt curve is then used to determine the first derivative (e.g., Tm value) and peak height. | 10-21-2010 |
20100268473 | METHODS, DEVICES, AND COMPOSITIONS FOR THE HIGHLY-SENSITIVE DETECTION AND IDENTIFICATION OF DIVERSE MOLECULAR ENTITIES - Embodiments of the present disclosure include a method for analysis of individual components in a multicomponent sample where the identity of the individual components is an indicator for disease. | 10-21-2010 |
20100268474 | METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR PREDICTING RESPONSIVENESS TO A PHARMACEUTICAL THERAPY FOR OBESITY OR EVALUATING INVESTIGATIONAL PHARMACEUTICAL AGENTS - Methods, systems, and computer program products using TRL V6 as a biomarker for the modulation of triglyceride and/or lipoprotein metabolism in a mammal induced by an investigational weight loss pharmaceutical agent. The biomarker may be used for predetermining if an individual patient will likely respond favorably to a given weight loss pharmaceutical agent and/or for testing a pharmaceutical agent's ability to modulate triglyceride and/or lipoprotein metabolism in a mammal. | 10-21-2010 |
20100268475 | ENVIRONMENT TEMPERATURE MEASURING METHOD, LIQUID SAMPLE MEASURING METHOD, AND MEASURING DEVICE | 10-21-2010 |
20100268476 | PROCESS FOR IDENTIFYING SIMILAR 3D SUBSTRUCTURES ONTO 3D ATOMIC STRUCTURES AND ITS APPLICATIONS - Our disclosure pertains to the field of structural biology and relates to a process to compare various three-dimensional (3D) structures and to identify functional similarities among them. Our process of comparison of 3D atomic structures is based on the comparisons of defined chemical groups onto the 3D atomic structures and allows the detection of local similarities even when neither the fold nor sequence for example aminoacid sequences for polypeptides sequences or nucleotide sequences for nucleic acid sequences are conserved. This process requires the attribution of selected physico-chemical parameters to each atom of a 3D atomic structure, then the representation of each 3D atomic structure by a graph of chemical groups. | 10-21-2010 |
20100268477 | Systems and Methods for Calibrating Physiological Characteristic Sensors - A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals, obtaining reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals, calculating the calibration characteristics using the reference glucose values and corresponding glucose monitor data to regress the obtained glucose monitor data, and calibrating the obtained glucose monitor data using the calibration characteristics. In additional embodiments, calculation of the calibration characteristics includes linear regression and, in particular embodiments, least squares linear regression. Alternatively, calculation of the calibration characteristics includes non-linear regression. Data integrity may be verified and the data may be filtered. Further, calibration techniques may be modified during a fast rate of change in the patient's blood glucose level to increase sensor accuracy. | 10-21-2010 |
20100274494 | BIOEQUIVALENCE EVALUATION METHOD OF EVALUATING BIOEQUIVALENCE OF A GENERIC DRUG TO THE CORRESPONDING ORIGINAL DRUG | 10-28-2010 |
20100274495 | NOVEL CLINICAL TRIAL METHODS TO IMPROVE DRUG DEVELOPMENT FOR DISEASE THERAPY AND PREVENTION - In one embodiment, a method for a multiplexed continuous biomarker clinical trial is disclosed that evaluates multiple drugs concurrently or subsequently against a continuously collected and enlarging control group with increasing statistical power. | 10-28-2010 |
20100274496 | DEVICE FOR MEASUREMENT OF TRANSPORT SYSTEMS - The invention relates to a device ( | 10-28-2010 |
20100274497 | Closed Loop Blood Glucose Control Algorithm Analysis - Methods and devices to generate a tool for testing, simulating and/or modifying a closed loop control algorithm are provided. Embodiments include receiving glucose data for a predetermined time period, determining a variation in the glucose level based on the received glucose data, filtering a received glucose data based on the determined variation, substituting a negative change in the glucose data value with a predetermined value to generate a sequence of modified glucose values, and integrating the sequence of modified glucose values to determine an uncontrolled blood glucose excursion condition. | 10-28-2010 |
20100274498 | INFORMATION PROVIDING SYSTEM AND ANALYZER - An information providing system comprises an analyzer and an information server communicatively connected to the analyzer through a network, which stores coping information regarding apparatus abnormalities of the analyzer, and the analyzer obtains the coping information corresponding to the apparatus abnormalities that occur to the analyzer from the information server, and displays this coping information on a display unit. | 10-28-2010 |
20100274499 | NUCLEIC ACID AMPLIFICATION DETERMINING METHOD AND NUCLEIC ACID AMPLIFICATION DETERMINING DEVICE - The present invention provides an amplification determining method that can determine whether or not an objective nucleic acid has been amplified with respect to a sample treated so as to amplify the nucleic acid. Signal values showing molten states of the treated sample at respective temperatures are provided, and the maximum signal value (A) is searched for. Further, signal differential values at the respective temperatures are calculated by differentiation of the signal values at two successive points, and second-order differential values of the differential values are calculated by differentiation at four successive points. Among the second differential values, from those in a predetermined temperature range including a Tm value of the objective nucleic acid, the maximum second differential value (D | 10-28-2010 |
20100274500 | METHOD AND SYSTEM FOR MEASURING MEMBRANE POTENTIAL BASED ON FLUORESCENCE POLARIZATION - A method of determining a membrane potential is disclosed. The method comprises (a) determining a difference in fluorescence polarization of a charged fluorescent probe being distributed across the membrane; and (b) determining a potential of the membrane, wherein the potential is proportional to the difference in the fluorescent polarization. | 10-28-2010 |
20100280758 | METHOD AND AN APPARATUS FOR DETERMINING NUCLEOTIDE SEQUENCE, AND A COMPUTER PROGRAM PRODUCT TO BE EXECUTED BY THE APPARATUS - A method for determining nucleotide sequence encompasses (a) injecting a solution containing a sample nucleic acid into a chip cartridge, (b) detecting first detection, second detection, and control signals through electrodes on the chip cartridge, (c) calculating a first difference between a mean value of the control signals and a mean value of the first detection signals, and dividing the first difference by the mean value of the control signals to define X, (c) calculating a second difference between the mean value of the control signals and a mean value of the second detection signals, and dividing the second difference by the mean value of the control signals to define Y, (d) calculating an angle between a positive X-axis and a vector from origin to a point (X, Y), and (d) comparing the angle with angle judgment criteria so as to identify a genotype of the sample nucleic acid. | 11-04-2010 |
20100280759 | MASS SPECTROMETER OUTPUT ANALYSIS TOOL FOR IDENTIFICATION OF PROTEINS - Methods and apparatus for consolidation and visualization of a dataset output from a mass spectrometer. The number of proteins identified in a mass spectrometry experiment may be systematically reduced by identifying and excluding proteins which may not be necessary to explain the observed peptides in a sample. Peptide counts from excluded proteins may be redistributed to non-excluded proteins to preserve total observed peptide counts. The consolidated dataset may be represented as a data structure having a plurality of cells arranged into rows and columns. Visual parameter values may be assigned to various cells in the data structure to emphasize particular features of the data. Data from multiple samples may be arranged in sets of columns in the data structure, and difference scores may be calculated to determine peptide expression differences between the multiples samples. The difference scores may be displayed using textual and/or graphical representations to facilitate data analysis. | 11-04-2010 |
20100280760 | BIOMARKERS FOR MONITORING TREATMENT OF NEUROPSYCHIATRIC DISEASES - Methods for identifying and measuring pharmacodynamic biomarkers of neuropsychiatric disease, and for monitoring a subject's response to treatment. For example, materials and methods for monitoring the effectiveness of transcranial magnetic stimulation in a subject having a neuropsychiatric disease are provided. | 11-04-2010 |
20100280761 | METHOD AND DEVICE FOR DETERMINING THE TRANSMEMBRANE PRESSURE IN AN EXTRACORPOREAL BLOOD TREATMENT - A method and device are provided for determining the transmembrane pressure during an extracorporeal blood treatment in which blood flows at a defined blood flow rate through an arterial blood conduit of an extracorporeal blood circuit into the inlet of a first chamber of a dialyzer, which is divided by a semipermeable membrane into the first chamber and a second chamber, and flows through a venous blood conduit from the outlet of the first chamber of the dialyzer, while dialysis liquid flows through a dialysis liquid supply conduit into the inlet of the second chamber of the dialyzer and flows through a dialaysis liquid discharge conduit from the outlet of the second chamber of the dialyzer. The method and the device for determining the transmembrane pressure are such that the pressure on the blood side and on the dialysis liquid side of the dialyzer is measured with relatively little technical outlay, specifically with fewer than four pressure sensors, and a preliminary uncorrected value is calculated for the transmembrane pressure and is thereafter corrected by a correction variable that is dependent on a variable correlating with the viscosity of the blood. | 11-04-2010 |
20100280762 | System and Method for Analyzing Biological Samples Using Raman Molecular Imaging - A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression. | 11-04-2010 |
20100280763 | BIOINFORMATIC TRANSACTION SCHEME - Secure network transaction system obtains user-authorized genetic term or bioinformatic profile, and transacts online service according to genetically-based user medical or other risk determined therefrom. Insurance policy, promotional offer, or other service may dynamically address genetically-based condition. Bioinformatic data classifies user per personal mask which filters subset of user genetic sequence. Risk profile may be calculated according to actuarial statistics, genetics and/or heredity using non-discriminatory rules specified for users in temporal or jurisdictional groups. User transactions are modifiable according to bioinformatic data representing genetically-based risk increase or decrease. Data is securely processed, modulated, and stored by network server for remote access and transaction using various portable user devices. | 11-04-2010 |
20100286923 | Computer-assisted means for assessing lifestyle risk factors - The present invention relates to methods of assessing disease susceptibility associated with dietary and lifestyle risk factors. The invention provides for analysis of alleles at loci of genes associated with lifestyle risk factors, and the disease susceptibility profile of an individual is determined by reference to datasets which further match the risk factor with lifestyle recommendations in order to produce a personalized lifestyle advice plan. | 11-11-2010 |
20100286924 | POLYMORPHISM DETECTION - The present invention generally provides a rapid efficient method for analyzing polymorphic or biallelic markers, and arrays for carrying out these analyses. In general, the methods of the present invention employ arrays of oligonucleotide probes that are complementary to target nucleic acids which correspond to the marker sequences of an individual. The probes are typically arranged in detection blocks, each block being capable of discriminating the three genotypes for a given marker, i.e., the heterozygote or either of the two homozygotes. The method allows for rapid, automatable analysis of genetic linkage to even complex polygenic traits | 11-11-2010 |
20100286925 | OLIGOMER SEQUENCES MAPPING - Mapping oligomer sequences includes receiving a set of related oligomer sequences, applying one or more key patterns derived from a set of oligomer sequence relationships to obtain one or more keys that are consistent with the set of related oligomer sequences, and locating the one or more keys in an index configured to map a plurality of possible keys to their respective candidate and/or validated locations in a reference. | 11-11-2010 |
20100286926 | COMBINATIONS OF POLYMORPHISMS FOR DETERMINING ALLELE-SPECIFIC EXPRESSION OF IGF2 - Combinations of SNPs and reagents for detecting such SNPs, as well as methods of detecting IGF loss-of-imprinting as provided. | 11-11-2010 |
20100286927 | Data Dependent Acquisition System for Mass Spectrometry and Methods of Use - Methods, systems and computer readable media for data dependent acquisition are provided. Using data representing isotopic clusters identified from a mass spectrum of a sample, a data dependent acquisition computer system is used to calculate a purity value for each isotopic cluster of interest in the mass spectrum, where each isotopic cluster of interest is identified within an isolation window used to obtain the data. A selection score based on the purity value is then calculated for each isotopic cluster of interest. The selection scores are then rank-ordered, and one or more of the highest selection scores are selected to identify those isotopic clusters, which correspond to the selected selection scores, for further processing. | 11-11-2010 |
20100292928 | SYSTEMS AND METHODS FOR GENERATING RANDOM FEASIBLE SOLUTIONS FOR AN EVOLUTIONARY PROCESS - Systems and methods may include identifying an input population of parent chromosome data structures, where each parent chromosome data structure provides a plurality of genes representative of variables in which associated values are permitted to evolve; selecting pairs of parent chromosome data structures from the input population of parent chromosome data structures; combining genes of each selected pair of parent chromosome data structures according to at least one evolutionary operator to generate a plurality of child chromosome data structures; evaluating the plurality of child chromosome data structures according to a plurality of constraint functions to generate a respective plurality of constraint function values for each child chromosome data structure, where the constraint functions define constraints on a feasible solution set; determining whether any of the plurality of child chromosome data structures are within the feasible solution set based upon the respective plurality of constraint violation function values. | 11-18-2010 |
20100292929 | SYSTEMS AND METHODS FOR GENERATING FEASIBLE SOLUTIONS FROM TWO PARENTS FOR AN EVOLUTIONARY PROCESS - Systems and methods may include receiving a pair of parent chromosome data structures, where each parent chromosome data structure provides a plurality of genes representative of variables that are permitted to evolve; combining genes of the two parent chromosome data structures to generate at least one first child chromosome data structure; evaluating the at least one first child chromosome data structures according to a plurality of constraint functions to generate a respective plurality of constraint function values for each of the at least one first child chromosome data structure, where the constraint functions define constraints on a feasible solution set; determining whether any of the at least one first child chromosome data structure is within the feasible solution set. | 11-18-2010 |
20100292930 | METHODS FOR GENERATING DATABASES AND DATABASES FOR IDENTIFYING POLYMORPHIC GENETIC MARKERS - Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided. | 11-18-2010 |
20100292931 | OPTICAL PLATFORM FOR SIMULTANEOUSLY STIMULATING, MANIPULATING, AND PROBING MULTIPLE LIVING CELLS IN COMPLEX BIOLOGICAL SYSTEMS - An optical platform and system for the simultaneous stimulation, manipulation and probing of multiple living cells in complex biological systems. The apparatus utilizes a spatiotemporal light modulator to expose a sample to pinpoints of light at selected times and wavelengths in two or three dimensional space and then detect the responses. In one embodiment, a spatiotemporal light modulator is optically coupled to a variable wavelength light source, a lens system and a system control unit with sample response sensors, wherein sample responses are detected after exposure to patterns of light in real time. Light patterns can be modulated in response to sample responses. | 11-18-2010 |
20100292932 | METHOD AND APPARATUS FOR ESTIMATING FEATURES OF TARGET MATERIALS BY USING KINETIC CHANGE INFORMATION - Disclosed are a method and an apparatus for estimating the features (concentration, weight, volume, etc.) of target materials, by using kinetic change information along time, when measuring the results of a chemical reaction between two materials, target materials and reactant, with an optical or electrochemical method. More precisely, the disclosed method and apparatus obtain in advance the correlation between accurate feature values of the target materials measured by a reference equipment and the kinetic change information related to the feature values of the target materials which is varying along the passage of time and indicates the results of chemical reaction measured by an optical or electrochemical method, and then estimates the feature values of the new samples using the correlation and the kinetic change information obtained from the new sample. In addition, the invention relates to a method and an apparatus for correcting errors by using kinetic change information of target materials, more particularly to a method and an apparatus for correcting the feature values of the first material by using the kinetic change information for the features (concentration, amount, etc.) of the first material, a correlation between the kinetic change information and the features of the second material, and a correlation between measurement errors of the features of the second material and the features of the first material. | 11-18-2010 |
20100299072 | SUBSTRATE CONCENTRATION MEASUREMENT METHOD AND SUBSTRATE CONCENTRATION MEASUREMENT APPARATUS - This invention is a method for a substrate concentration measurement method including measuring a concentration of a substrate in a blood specimen containing hemoglobin. In the method, the substrate concentration is calculated by using a measurement value correlating with a substrate concentration influenced by hemoglobin, and a hemoglobin concentration or a value correlating with the hemoglobin concentration. A substrate concentration is calculated by correcting the measurement value Re correlating with the substrate concentration based on the following Formulae 1 and 2: [Formula 1] Corrected value=100×Re/V (%), wherein V (%) represents a value with respect to plasma (a ratio of a measurement value influenced by hemoglobin with respect to a measurement value obtained by measuring plasma), and Re represents the measurement value correlating with the substrate concentration influenced by hemoglobin; [Formula 2] Value with respect to plasma V (%)=(Vmax×Re)/(Km+Re)+B, wherein Vmax represents a value obtained by subtracting an intercept (B) from the value (V) with respect to plasma which is maintained constant even when the measurement value influenced by hemoglobin increases, Km represents a value of Re at which the value V (%) with respect to plasma becomes Vmax/2, and B represents a value (constant) of V (%) with respect to plasma when Re is 0. | 11-25-2010 |
20100299073 | DIVE COMPUTER FOR A PLURALITY OF USERS - Dive computer with at least one measuring device for detecting measured variables, at least one memory device, at least one computing device, at least one data transmitter, and one display device for displaying information. The memory device has at least one first area and at least one second area in which data are stored that are allocated to at least one first or at least one second user. There is also a selector for selecting the user to whom the data currently detected by the measuring device are allocated. | 11-25-2010 |
20100299074 | REMOTE DATA COLLECTING SYSTEMS AND METHODS - The present invention provides a remote data collecting system comprising a measuring device comprising at least two scales in communication with a terminal center. The terminal center is in communication with a control center. The control center can be linked to a computer with software to collect, distribute, analyze, and display data collected from the measuring device. The remote data collecting system is particularly useful for uncontrolled environment (e.g., in-home) product testing such as testing the palatability of pet foods. | 11-25-2010 |
20100299075 | SYSTEMS AND METHODS FOR CALCULATING AN AVERAGE ANALYTE CONCENTRATION VALUE - Embodiments provide methods and systems wherein analyte concentration readings taken over a first period of time are collected and processed to determine one or more analyte concentration averages. The methods include collecting samples with a measurement system (e.g., a Blood Glucose Meter) over a first period of time, dividing the first period of time into smaller time increments, and calculating an average analyte concentration based on first sub-averages obtained from each of the smaller time increments. Systems for carrying out the analyte concentration averages are described, as are other aspects. | 11-25-2010 |
20100299076 | Mass Spectrometry System - (EN) MS analysis, MS | 11-25-2010 |
20100299077 | SYSTEMS AND METHODS FOR APPLYING SCALING LAWS OF TREE STRUCTURES - In at least one embodiment, a method for determining the resistance of a flow within at least a portion of a vessel is provided, with the method comprising the steps of obtaining a biological tree image showing a structure of at least part of a biological tree, identifying a length of a vessel portion and a diameter of a stem vessel proximal to the vessel crown from the biological tree image, and calculating resistance based upon at least the length of a vessel portion and a diameter of a stem vessel proximal to the vessel crown. In another embodiment, a method for determining vessel volume is provided, with the method comprising the steps of obtaining a biological tree image showing a structure of at least part of a biological tree, identifying a diameter of a stem segment and a length of a stem segment from the biological tree image, and calculating cumulative crown volume based upon at least the diameter of the stem segment and the length of the stem segment. | 11-25-2010 |
20100305867 | ANALYSIS OF AQUIOUS SAMPLE BY LIGHT TRANSMITTENCE - A method for analysis of an aqueous sample includes determining a first reading of a sample, and comparing the first reading to a first read index to determine a first read probability wherein the first read probability gives either a positive or a negative result for the sample. The method includes determining a second reading for the sample, and comparing the second reading to a second read index, wherein a second read probability is determined according to the reading and the second read index. The second read probability gives either a positive or a negative result for the sample. From the first and second readings, a species and a life phase of the species are determined. | 12-02-2010 |
20100305868 | Method and system for determining whether a drug will be effective on a patient with a disease - A process of determining whether a patient with a disease or disorder will be responsive to a drug, used to treat the disease or disorder, including obtaining a test spectrum produced by a mass spectrometer from a serum produced from the patient. The test spectrum may be processed to determine a relation to a group of class labeled spectra produced from respective serum from other patients having the or similar clinical stage same disease or disorder and known to have responded or not responded to the drug. Based on the relation of the test spectrum to the group of class labeled spectra, a determination may be made as to whether the patient will be responsive to the drug. | 12-02-2010 |
20100305869 | TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. | 12-02-2010 |
20100312482 | FRET DETECTION METHOD AND DEVICE - When FRET efficiency is measured quantitatively by removing uncertain elements of fluorescence detection information, calibration information prestored in a storage means while including at least the leak rate of donor fluorescence component emitted from a donor molecule, the leak rate of acceptor fluorescence component emitted from an acceptor molecule, and the non-FRET fluorescence lifetime of the donor fluorescence component when FRET is not generated out of the fluorescence of a measurement object sample is acquired. The FRET fluorescence lifetime of the donor fluorescence component is then determined using the intensity information and phase information of fluorescence of the measurement object sample, the leak rate of donor fluorescence component and the leak rate of acceptor fluorescence component, thus determining the FRET fluorescence efficiency. | 12-09-2010 |
20100312483 | ALGORITHMS FOR CALIBRATING AN ANALYTE SENSOR - Disclosed are embodiments that relate to algorithms and methods for calibrating an analyte sensor, and more particularly, to algorithms for calibrating an optical glucose sensor comprising an equilibrium fluorescent chemical indicator system. In particular, a method of detecting an analyte concentration is disclosed where a modified Michaelis-Menten equation comprising Michaelis-Menten parameters is used to characterize the signal generated by the analyte sensor. | 12-09-2010 |
20100312484 | SYSTEM FOR MONITORING OF AND MANAGING COMPLIANCE WITH TREATMENT FOR OBSTRUCTIVE SLEEP APNEA USING ORAL APPLIANCE THERAPY AND METHOD THERFOR - A system and method for monitoring of and managing compliance with treatment for obstructive sleep apnea using oral appliance therapy comprises a sensor module installed in an oral appliance, a data communications facility for communicating with the oral appliance, a control module, and a central database for storing data. Data stored on the sensor module is transferred to the data communications facility for local storage. The control module validates the locally stored temperature data and uploads the validated data into the central database. Temperature data stored in the central database may be viewed remotely via a secure computer network connection in graphical form by authorized users using role-based access controls. Authorized users may include the patient, the patient's provider, system administrators, and stake holders including insurance carriers providing medical coverage for OAT. | 12-09-2010 |
20100312485 | Method and arrangement for determination of the individual incretin sensitivity index of a subject - A computer-aided method for determination of a subject's individual incretin sensitivity index determines the individual metabolic situation in the form of the personal metabolic situation of the subject. The individual incretin effect factor and the effect found of the administered incretin mimetic or incretin enhancer by simulation for the mean deviation of the daily glycemia are determined with the personal metabolic situation data and recorded numerically. The corresponding effect factor of a slow-acting insulin, whose step-by-step administration is varied until the mean deviation of the daily glycemia is identical to the mean deviation of the daily glycemia determined previously by the incretin mimetic or incretin enhancer, is determined. The insulin dosage is recorded numerically. The individual incretin sensitivity index is calculated from the relationship between the dosages of the incretin mimetic or incretin enhancer determined for identical deviation of the daily glycemia and the respectively individually different insulin dosage. | 12-09-2010 |
20100312486 | METHODS FOR ANALYZING HIGH DIMENSIONAL DATA FOR CLASSIFYING, DIAGNOSING, PROGNOSTICATING, AND/OR PREDICTING DISEASES AND OTHER BIOLOGICAL STATES - A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised pattern recognition method, ranking individual data points from the data, wherein the ranking is dependent on the outcome of the supervised pattern recognition method, choosing multiple data points from the data, wherein the choice is based on the relative ranking of the individual data points, and using the multiple data points to determine if an unknown set of experimental data indicates a diseased condition, a predilection for a diseased condition, or a prognosis about a diseased condition. | 12-09-2010 |
20100318300 | Method for Object Recognition - A method for recognizing an object that has a plurality of expressions of abstract object characteristics, and is associated with an object characteristic class of a hierarchical system of object characteristic classes stored in a first memory. The method includes i) observing at least one location at which the object is presumed to be present, using a plurality of sensors in a sensor population, each of said sensors responding to at least one object characteristic and accordingly emitting a sensor signal; ii) checking whether each of the emitted sensor signals exceeds a specified threshold value for the sensor signals, and accepting sensor signals which exceed the threshold value; iii) pairing combinations of the sensor characteristics, for the accepted sensor signals obtained in ii) to form identification characteristic pairs; iv) comparing the population of identification characteristic pairs obtained in iii) to the object characteristic classes stored in the first memory; and v) identifying the object, based on the object characteristic class, whose object characteristic pairs are identical to the identification characteristic pairs obtained in iii). | 12-16-2010 |
20100318301 | METHOD AND SYSTEM FOR ASSESSING IMMUNE SYSTEM RESPONSE - A method and system for determining the extent to which a patient will respond to a therapeutic regimen by assessing how that regimen will impact the functioning of a patient's immune system. An extent to which a patient will respond to a therapeutic regimen may be assessed based on a set of values for measurable parameters that relate to one or more characteristics of the patient's immune system, and receptor-ligand binding and trafficking characteristics of the patient's immune system, as well as other optional parameters and characteristics of the immune system. A mathematical model of the immune system is provided and may be implemented to predict immune system response, as well as identify parameters that have a greatest impact on predicting immune system response. | 12-16-2010 |
20100324827 | Fluid Responsiveness Measure - A method and system for measuring fluid responsiveness of a patient is disclosed. Information related to fluid responsiveness of a patient may be derived from a PPG signal, for example, by analyzing the PPG signal transformed by a continuous wavelet transform. Other techniques for deriving information related to fluid responsiveness of a patient include, for example, analyzing the amplitude modulation, frequency modulation, and/or baseline changes of a PPG signal. | 12-23-2010 |
20100324828 | SENSOR DEVICE FOR AND A METHOD OF SENSING MAGNETIC PARTICLES - A sensor device ( | 12-23-2010 |
20100324829 | METHOD OF SELECTING HLA-DP4 LIGANDS AND THE APPLICATIONS THEREOF - A method of selecting a test molecule that binds to HLA-DP4 by (i) incubating HLA-DP4 with the test molecule and a labeled peptide of formula (I) Z | 12-23-2010 |
20100324830 | HANDHELD OPTICAL SENSOR FOR MEASURING THE NORMALIZED DIFFERENCE VEGETATIVE INDEX IN PLANTS - A handheld sensor is disclosed. The sensor has a microcontroller, a current pulse control unit coupled to a light emitting diode (LED), and a photodiode. The microcontroller controls the current pulse control unit to provide a pulsed illumination of a target plant and the photodiode reads the magnitude of the reflectance from the target plant. The microcontroller accepts the reading from the photodiode and computes a normalized difference vegetative index (NDVI) based at least on the reading. | 12-23-2010 |
20100332140 | METHOD OF ASSESSING THE EATING EXPERIENCE OF A COMPANION ANIMAL - A method of assessing the eating experience of a companion animal. Further, a feeding device utilized in assessing the eating experience of a companion animal. Further, a method of modifying at least one attribute of a food product as a result of assessing the eating experience of a companion animal. | 12-30-2010 |
20100332141 | ANALYZER APPARATUS AND METHODS FOR LUNG DISEASE - An apparatus arranged to give an output indicative of lung disease state, in particular Chronic Obstructive Pulmonary Disease (COPD). The apparatus comprises a biomarker detection unit; a patient information input unit; a memory unit; a processing unit; and an output unit. The biomarker detection unit generates biomarker information by analyzing a patient saliva sample. The biomarker information is processed with patient information relating to patient symptoms, and an appropriate output generated based on the combination of the biomarker information and the patient information. The output suitably indicates whether there is a change in the disease state, and may further include a recommendation regarding treatment for the disease according to such a change. | 12-30-2010 |
20100332142 | ANALYTE TESTING METHOD AND DEVICE FOR CALCULATING BASAL INSULIN THERAPY - Described herein are various methods to ensure safety and the compliance of therapeutic diabetes protocols. The method can be achieved by performing safeguards against hypoglycemia of the user prior to any change in basal insulin dosage based on the plurality of data. | 12-30-2010 |
20100332143 | Method, Computer Program Product and System for Enabling Clinical Decision Support - A method enables clinical decision support based on test results for a plurality of tested biomarkers. The method is executed by a data reduction module ( | 12-30-2010 |
20100332144 | ANALYSIS APPARATUS AND MEASUREMENT UNIT - This analysis apparatus includes a plurality of a plurality of measurement units of mutually identical types generating measurement data by measuring the specimens, a transporter transporting the specimens to the respective ones of the plurality of measurement units, a display, common to the plurality of measurement units, displaying the analytical results generated by analyzing the measurement data and a transmitter transmitting the analytical results to a host computer. | 12-30-2010 |
20110004410 | DEVICE FOR THE COLLECTION AND PROCESSING OF INFORMATION RELATING TO THE EXPOSURE OF ONE OR MORE PERSONS TO ONE OR MORE PRODUCTS OF CHEMICAL OR BIOLOGICAL ORIGIN AND METHOD FOR THE USE OF SUCH A DEVICE - A device for the collection and processing of information relating to the exposure of one or more persons ( | 01-06-2011 |
20110004411 | METHOD FOR ADJUSTING RESULTS OF A POLYMERASE CHAIN REACTION (PCR) INSTRUMENT - Methods of managing results of a real-time polymerase chain reaction (PCR) instrument and software associated with such methods are described herein. One disclosed method, among others, comprises calculating, from results of the real-time PCR instrument, a fluorescence signal of a sample during a cycle of a baseline period of the real-time PCR instrument. The method further comprises determining whether or not the fluorescence signal during the baseline period increases by at least a certain percentage compared to cycles outside the baseline period. The sample is flagged as a potentially high-titer sample when the fluorescence signal increases by at least the certain percentage. | 01-06-2011 |
20110004412 | CLINICAL APPLICATIONS OF NEUROPSYCHOLOGICAL PATTERN ANALYSIS AND MODELING - A method for functional analysis of neurophysiological data by decomposing neurophysiological data and EEG signal to form a plurality of signal features. The signal features may then optionally be analyzed to determined one or more patterns. | 01-06-2011 |
20110004413 | METHOD AND SYSTEM FOR CALLING VARIATIONS IN A SAMPLE POLYNUCLEOTIDE SEQUENCE WITH RESPECT TO A REFERENCE POLYNUCLEOTIDE SEQUENCE - Embodiments for calling variations in a sample polynucleotide sequence compared to a reference polynucleotide sequence are provided. Aspects of the embodiments include executing an application on at least one computer that locates local areas in the reference polynucleotide sequence where a likelihood exists that one or more bases of the sample polynucleotide sequence are changed from corresponding bases in the reference polynucleotide sequence, where the likelihood is determined at least in part based on mapped mated reads of the sample polynucleotide sequence; generating at least one sequence hypothesis for each of the local areas, and optimizing the at least one sequence hypothesis for at least a portion of the local areas to find one or more optimized sequence hypotheses of high probability for the local areas; and analyzing the optimized sequence hypotheses to identify a series of variation calls in the sample polynucleotide sequence. | 01-06-2011 |
20110004414 | Method for Predicting Respiratory Toxicity of Compounds - The invention provides methods for analyzing and predicting the in vivo respiratory toxicity of a compound (e.g., pharmaceutical, biological, cosmetic, or chemical compounds) or composition comprising a combination of an in vitro mammalian cell model with multiple endpoint analysis, and time and concentration response curves. The methods allow the determination of a predicted in vivo respiratory toxicity value of a compound without the use of animals, with a high degree of accuracy. The methods comprise detecting any combination of cell viability markers and expression levels of genes implicated in respiratory toxicity and/or sensitization, such as pro-inflammatory response genes, combining the viability and gene expression level data with concentration response and time response data, conducting a computational analysis, and comparing test compound data to a database of known respiratory toxicants/sensitizers to predict and/or analyze the respiratory toxicity. An indication of organ specificity is provided by a toxicity index, which is determined by comparing mean IC | 01-06-2011 |
20110004415 | DIGITAL CELL - It is intended to provide a method and system for carrying out data production with respect to the actual status of cells as a profile. It is also intended to provide a system and method for presenting time-lapse and/or real-time information of cell interior directly, or as it is, from the viewpoint of a complex system. It is further intended to provide a method of presenting a digital cell. Thus, there is provided a method of producing profile data relating to cell information, comprising the step (a) of arranging cells in an immobilized form on a support and the step (b) of monitoring over time biological factors on or inside the cells or an aggregate thereof, thereby producing profile data for the cells. Furthermore, there is provided a method of producing a digital cell, comprising procuring experimental data by the use of the above method. | 01-06-2011 |
20110004416 | METHODS AND SYSTEMS FOR CONSERVATIVE EXTRACTION OF OVER-REPRESENTED EXTENSIBLE MOTIFS - Methods and systems of extracting extensible motifs from a sequence include assigning a significance to extensible motifs within the sequence based upon a syntactic and statistical analysis, and identifying extensible motifs having a significance that exceeds a predetermined threshold. | 01-06-2011 |
20110010099 | Correlation Analysis of Biological Systems - The present teachings relate to gaining insight into biological states, e.g., disease states or drugged states, by gathering, integrating, and combining biomolecular data. More particularly, the present teachings relate to methods and systems for profiling a state of a biological system, finding accessible biomarkers representative of the state of a biological system, and deriving insights into the biochemistry of a biological system for therapeutic, diagnostic, prognostic and other purposes. | 01-13-2011 |
20110010100 | FUNCTIONAL DOMAIN ANALYSIS METHOD AND SYSTEM - One embodiment of the present disclosure relates to methods for assessing the biological effects of a test agent or test condition on a test sample by comparing one or more characteristics of the biomarkers of the test sample with that of one or more reference samples and assessing the biological effects of the test agent or test condition based on the biological effects of one or more reference agents or reference conditions on the one or more reference samples, as well as computer program products for executing such methods, computer readable storage media encoding such computer programs, and computer systems for performing such methods. | 01-13-2011 |
20110010101 | SIMPLIFIED PERITONEAL EQUILIBRATION TEST FOR PERITONEAL DIALYSIS - A simplified peritoneal equilibration test (S-PET) is disclosed. Instead of a lengthy peritoneal equilibration test (PET), the simplified procedure requires no blood sample and may use data from as few as two or three samples to classify a peritoneal membrane of a user. Typically, a peritoneal membrane or peritoneum of a dialysis patient, or other person, is classed as a high transport membrane, high-average transport membrane, a low-average transport membrane or a low transporter membrane. The S-PET may be performed at home by a user without the need to submit a blood sample. Kits for analyzing the samples may be furnished for home use. The kits may use disposable strips, microfluidic analyzers or chemical reagents, or may alternatively include reusable analysis equipment, such as optical or conductivity analysis equipment. | 01-13-2011 |
20110010102 | Methods and Systems for Sequence-Directed Molecular Breeding - The present invention provides breeding methods and compositions to enhance the germplasm of a plant by the use of direct nucleic acid sequence information. The methods describe the identification and accumulation of preferred nucleic acid sequences in the germplasm of a breeding population of plants. | 01-13-2011 |
20110010103 | RAPID METHOD OF PATTERN RECOGNITION, MACHINE LEARNING, AND AUTOMATED GENOTYPE CLASSIFICATION THROUGH CORRELATION ANALYSIS OF DYNAMIC SIGNALS - The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of determining whether a genotype is present in a biological sample. The present invention includes methods and systems for determining whether a genotype is present in a biological sample, through generating a dynamic profile an unknown genotype, correlating the dynamic profile to an average profile for a known genotype to generate a correlation value, and determining whether the correlation value falls within an acceptable threshold to determine if the unknown genotype is the known genotype. The present invention also relates to methods and systems for generating a training set to allow a machine to recognize a known genotype from within a class of known genotypes through generating dynamic profiles of a known genotype, averaging the dynamic profiles to generate an average profile for the genotype, and correlating the dynamic profiles of the genotype with an average profile for each known genotype in a class of genotypes to generate a correlation vector. The training set generated by these methods and systems may be used to assist in identification of unknown genotypes. | 01-13-2011 |
20110010104 | METHODS AND SYSTEMS FOR DETECTING THE HYDRATION OF SENSORS - A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes. | 01-13-2011 |
20110010105 | METHODS AND SYSTEMS FOR DETECTING THE HYDRATION OF SENSORS - A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes. | 01-13-2011 |
20110010106 | APPARATUS STATE DETECTOR, METHOD FOR DETECTING APPARATUS STATE, APPARATUS STATE DETECTION SERVER AND APPARATUS STATE DETECTION SYSTEM; LIVING PERSONS' ANOMALY DETECTOR, LIVING PERSONS' ANOMALY DETECTION SYSTEM AND METHOD FOR DETECTING LIVING PERSONS' ANOMALY, AND APPARATUS-STATE DATABASE MAINTENANCE SERVER - An apparatus state detector and its associates are provided to save time and effort for learning combinations of operation states of all apparatuses at home and commit fewer estimation errors even when an unknown apparatus starts operating. The apparatus state detector includes measuring means | 01-13-2011 |
20110015863 | METHOD FOR IDENTIFICATION AND SEQUENCING OF PROTEINS - Protein samples are processed to create a mixture of modified and unmodified or overlapping peptides which are analyzed using mass spectrometry. Correlations between the MS/MS spectra of peptide pairs allow the noise in individual MS/MS spectra to be greatly reduced. A small number of peptide reconstructions can be generated that are likely to contain the correct one. This allows for the de novo reconstruction of protein sequences and peptide and modification identification through a database search using extremely fast pattern matching, rather than time-consuming matching of spectra against databases. | 01-20-2011 |
20110015864 | OLIGOMER SEQUENCES MAPPING - Mapping oligomer sequences includes receiving a set of related oligomer sequences, applying one or more key patterns derived from a set of oligomer sequence relationships to obtain one or more keys that are consistent with the set of related oligomer sequences, modifying positions within these keys, and locating the one or more keys in an index configured to map a plurality of candidate and/or validated keys to their respective possible and/or validated locations in a reference. | 01-20-2011 |
20110015865 | DETERMINATION OF CORONARY ARTERY DISEASE RISK - Markers and methods useful for assessing coronary artery disease in a subject are provided, along with kits for measuring their expression. Also provided are predictive models, based on the markers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. | 01-20-2011 |
20110015866 | Active Interface Device - An active interface device including a transducer or sensor array having a plurality of transducers or sensors arranged to transform a cell activity into an electrical signal, at least one detection unit for detecting the electrical signal(s), at least one recording unit for recording the electrical signal(s), comprising a plurality of recording channels arranged for being routed to the transducers or sensors, and at least one control unit. The control unit is arranged for addressing the transducers or sensors to the detection unit(s), for activating transducers or sensors, and for routing the recording channels to activated transducers or sensors. | 01-20-2011 |
20110015867 | METHOD FOR REDESIGN OF MICROBIAL PRODUCTION SYSTEMS - A computer-assisted method for identifying functionalities to add to an organism-specific metabolic network to enable a desired biotransformation in a host includes accessing reactions from a universal database to provide stoichiometric balance, identifying at least one stoichiometrically balanced pathway at least partially based on the reactions and a substrate to minimize a number of non-native functionalities in the production host, and incorporating the at least one stoichiometrically balanced pathway into the host to provide the desired biotransformation. A representation of the metabolic network as modified can be stored. | 01-20-2011 |
20110015868 | METHOD AND APPARATUS FOR WAVEFORM ANALYSIS OF PHYSIOLOGICAL PARAMETERS - A method and an apparatus are provided for performing waveform analysis on physiological parameters. In one embodiment, a method includes reading measurement values of a first physiological parameter relating to time, and displaying them as a trend display graph in a trend display area that includes first coordinates representing time and second coordinates representing the measurement values. The method also includes acquiring a time selected in the trend display graph, and displaying, in a waveform display area, waveform data of a second physiological parameter associated with formation of the first physiological parameter during periods before and after the selected time. The waveform display area includes time coordinates. The disclosed embodiments allow medical staff to view the curve of a patient's physiological parameters throughout a monitoring/therapy period. Medical staff may make a detailed analysis of the waveform data in real time, which may provide a basis for making decisions in the following therapy processes. | 01-20-2011 |
20110015869 | METHODS AND GENE EXPRESSION SIGNATURE FOR ASSESSING GROWTH FACTOR SIGNALING PATHWAY REGULATION STATUS - Methods, biomarkers, and expression signatures are disclosed for assessing the regulation status of growth factor pathway signaling in a cell sample or subject. More specifically, several aspects of the invention provide a set of genes which can be used as biomarkers and gene signatures for evaluating growth factor pathway deregulation status in a sample; classifying a cell sample as having a deregulated or regulated growth factor signaling pathway; determining whether an agent modulates the growth factor signaling pathway in sample; predicting response of a subject to an agent that modulates the growth factor signaling pathway; assigning treatment to a subject; and predicting evaluating the pharmacodynamic effects of cancer therapies designed to regulate growth factor pathway signaling. | 01-20-2011 |
20110022323 | System and Method to Determine Sigma of a Clinical Diagnostic Process - A system and method for determining a sigma of a clinical diagnostic process are disclosed. Specimen data are collected from a plurality of laboratory instruments. The specimen data are evaluated to determine a concentration and an analytical standard deviation for each data point. A clinical diagnostic process is run and patient analyte values are acquired, and a standard deviation is assigned to each patient analyte value based on the standard deviation of specimen data having a corresponding concentration. A single sigma-metric is computed based on the patient analyte assigned standard deviations, the sigma-metric representing the sigma of the clinical diagnostic process. The computed sigma-metric is reported to a user or laboratory manager. | 01-27-2011 |
20110022324 | MOLECULAR READER - Systems and methods disclosed include: a support apparatus configured to detachably receive a chip; movable pins extendible from a first position to a second position, where, in the first position, the movable pins do not contact a chip positioned on the support apparatus, and in the second position, the movable pins contact electrical terminals of a heating element within a chip positioned on the support apparatus; a radiation source configured to direct radiation to be incident on a chip positioned on the support apparatus; a detector; and an electronic processor, the electronic processor being configured to detect molecules in a sample positioned within the chip, and to determine a temperature of the chip by measuring an electrical resistance between two of the multiple pins connected to the electrical terminals. | 01-27-2011 |
20110022325 | Methods and Apparatus for Measuring the Contents of a Search Volume - A method of measuring the contents of a search volume. The method includes: energising one or more transmitters so as to transmit electromagnetic wave energy into the search volume; detecting the effect of the search volume on the passage of the electromagnetic wave energy by recording two or more signals, each signal being associated with a different propagation path (typically either a monostatic or bistatic path) within the search volume; aligning the signals in order to generate two or more aligned signals which are synthetically focused on a desired voxel in the search volume, each aligned signal being associated with a different propagation path (typically either a monostatic or bistatic path) within the search volume; calculating a quality factor by processing the aligned signals to generate two or more data values, and processing the data values to generate a quality factor, the quality factor being indicative of a degree of coherence in the aligned signals; summing the aligned signals to generate a summed signal; and processing the summed signal to generate an output which is indicative of the internal structure of the search volume at the location of the desired voxel, the output varying in accordance with the quality factor. | 01-27-2011 |
20110022326 | Quantitation Method Using Isotope Labeled Internal Standard Substance, Analysis System for Executing the Quantitation Method, and Program for the Analysis - Problem: An object of the present invention is to quantitate with good accuracy, furthermore, quantitate absolutely, one or a plurality of biological molecules in a sample such as a tissue, a biological fluid, a cell, a cell organ or protein complex. | 01-27-2011 |
20110022327 | URINE WORK AREA MANAGER FOR A URINE WORK AREA - A urine work area manager comprises a computing unit and a set of machine executable instructions stored in a memory for execution by the computing unit. The computing unit transfers commands and data between a urine test strip reader and the manager using a first interface, and transfers commands and data between a urine sediment analyzer and the manager using a second interface. In operation, the computing unit instructs the urine test strip reader to analyze a plurality of urine samples, receives a strip analysis result from the urine test strip reader, and generates a first set of instructions for controlling the urine sediment analyzer using the strip analysis result. The computing unit further instructs the urine sediment analyzer to analyze the plurality of urine samples with the first set of instructions and receives a sediment analysis result from the urine sediment analyzer using the second interface. | 01-27-2011 |
20110022328 | Methods And Devices For Analyzing Material Properties And Detecting Objects In Scattering Media - Disclosed is a method for determining an phase spectrum θ(ω) of the complex spectral transfer function H(ω) of a medium. In some embodiments, the method is applied for detecting or imaging an object screened by scattering medium or for determining a refractive index spectrum of a material. | 01-27-2011 |
20110022329 | Method and Apparatus For Determining Seed Germination - A method is provided for determining the rate of seed germination including the steps of (a) irradiating a selected number or quantity of seeds with light from an NIR spectrometer which is combined with or coupled to a pre-defined calibration model, wherein the light reflects to a detector; (b) collecting the reflected light from the detector; (c) converting the reflected light to an NIR spectrum; and (d) determining the rate of germination using the NIR spectrum obtained and the calibration model. Also provided is a cup for use with an NIR spectrometer including a rotating cylindrical member for receiving a selected number or quantity of seeds coupled to a transparent base through which NIR light is irradiated. | 01-27-2011 |
20110022330 | MONITORING APPARATUS - A monitoring system is disclosed which includes at least one experiment node at which, in use of the system, a user participates in a study, and a control node. The experiment node includes communication devices operable to communicate with the user, a user input operable to record the response of a user to a prompt, a user interaction device operable such that the user can interact with the experiment node, and a device to record data relating to such user interactions. The control node is remote from the experiment node and in communication therewith to receive information including user responses and recorded user interaction data therefrom. The control node is also operable to configure the at least one experiment node to execute a plurality of human factors tests on the participant at predetermined times. The monitoring apparatus also includes a co-ordination device operable to co-ordinate the information with the predetermined times. | 01-27-2011 |
20110029247 | Exponential Sampling Of Red And Infrared Signals - Methods and systems are provided that include sampling a light intensity signal at different frequencies based on the waveform of the signal to produce a more accurate digitized signal. The light intensity signal is an analog signal proportional to the intensity of light received at a detector of a pulse oximetry system. In one embodiment, the signal may be sampled exponentially during pulse width periods, such that the end of the pulse width periods where the signal reaches a maximum amplitude may be sampled more frequently. The signal may also be exponentially sampled or oversampled during periods when the signal is expected to near maximum amplitude. Further, the signal may be sampled less frequently during low amplitude periods of the signal, and during dark periods, such that processing power may be conserved. | 02-03-2011 |
20110029248 | APPARATUS FOR MEASURING AND PREDICTING PATIENTS' RESPIRATORY STABILITY - An apparatus ( | 02-03-2011 |
20110029249 | DETERMINATION OF BLOOD VOLUME IN A CULTURE BOTTLE - Systems, methods and apparatus for determining an amount of blood in a blood culture are provided where an initial biological state and then periodic measurements of the biological state of the culture are taken. For each respective measurement, a normalization relative value between the respective measurement and the initial measurement is made thereby forming normalization relative values. For each interval of time points represented by the normalization relative values, a first derivative of the normalization relative values in the interval is made thereby forming a plurality of rate transformation values. For each set of rate transformation values in the plurality of rate transformation values, an average relative transformation value is computed, thereby forming average relative transformation values. A lookup table that matches a measure of central tendency of the average relative transformation values to a blood amount is used to determine the amount of blood in the culture. | 02-03-2011 |
20110029250 | Non-Parametric Modeling Apparatus and Method for Classification, Especially of Activity State - The activity state classification method of the present invention employs a kernel-based modeling technique, and more specifically a set of similarity-based models, which have been created using example data, to process an input observation or set of input observations, each comprising a set of sensor readings or “features” derived there from or other data, to predict the activity state of a person from whom the sensor data was obtained. A model is created for each class of activity. The input data is processed by each model and the resulting predictions are combined to yield a final prediction of which state of activity is represented by the input data. | 02-03-2011 |
20110029251 | Methods for Identifying DNA Copy Number Changes - Methods of identifying allele-specific changes in genomic DNA copy number are disclosed. Methods for identifying homozygous deletions and genetic amplifications are disclosed. An array of probes designed to detect presence or absence of a plurality of different sequences is also disclosed. The probes are designed to hybridize to sequences that are predicted to be present in a reduced complexity sample. The methods may be used to detect copy number changes in cancerous tissue compared to normal tissue. The methods may be used to diagnose cancer and other diseases associated with chromosomal anomalies. | 02-03-2011 |
20110029252 | HIGH CONFIDENCE IN POSITIVE STATUS DETERMINATION - Systems, methods, and apparatus for determining whether a culture in a vessel contains a plurality of microorganisms are provided. A normalization relative value is calculated for each respective measurement of a biological state of the culture between (i) the respective measurement and (ii) an initial biological state. For each fixed interval of time points, a derivative of the normalization relative values in the interval of time points is calculated, thereby forming a plurality of rate transformation values. For each set of rate transformation values in the plurality of rate transformation values, a measure of central tendency of the values in the set is computed, thereby forming a plurality of average relative transformation values. A determination whether the culture contains the microorganisms is made based on whether any calculated average relative transformation value exceeds a first threshold or whether an extent of growth exhibited by the culture exceeds a second threshold. | 02-03-2011 |
20110035155 | PROTEIN AGGREGATION PREDICTION SYSTEMS - We describe methods for identifying aggregation-prone regions in structured—that is folded—proteins. Embodiments of the method use a local propensity for aggregation (A | 02-10-2011 |
20110035156 | Method of evaluating gastric cancer, gastric cancer-evaluating apparatus, gastric cancer-evaluating method, gastric cancer-evaluating system, gastric cancer-evaluating program and recording medium - According to the method of evaluating gastric cancer of the present invention, amino acid concentration data on the concentration value of amino acid in blood collected from a subject to be evaluated is measured, and a gastric cancer state in the subject is evaluated based on the concentration value of at least one of Asn, Cys, His, Met, Orn, Phe, Trp, Pro, Lys, Leu, Glu, Arg, Ala, Thr, and Tyr contained in the measured amino acid concentration data of the subject. | 02-10-2011 |
20110035157 | BIOMASS CONCENTRATION MEASUREMENT DEVICE AND METHOD AND USE OF AN ELECTRONIC CHIP ELEMENT FOR MEASURING SAID BIOMASS CONCENTRATION - The invention relates to devices and methods for measuring a concentration of a biomass suspended in a medium. Embodiments of the device include a substrate capable of being immersed in the medium, at least two electrodes integrated in the substrate, and a processing and control circuit electromagnetically coupled to the at least two electrodes. The processing and control circuit is configured to apply an electrical potential to the at least two electrodes, the applied electrical potential generating a stationary electric charge that leads to the appearance of an electrical double layer on a surface of one of the at least two electrodes and that causes a biomass electrostatic adhesion on the surface, measure a change in capacitance of the electrical double layer in response to the biomass electrostatic adhesion, and determine the concentration of the biomass using a calibration curve that correlates the change in capacitance with the concentration. | 02-10-2011 |
20110035158 | METHODS OF AND DEVICES FOR MONITORING THE EFFECTS OF CELLULAR STRESS AND DAMAGE RESULTING FROM RADIATION EXPOSURE - Methods of and devices for detecting a measurable characteristic of the gas sample. The methods and devices are able to detect a value of or a change of measurable characteristic (e.g., such as chemical concentrations), a change of chemical compositions and/or biological responses of a living organism that are induced by a stressor. The biological responses are able to include cellular stress, damage, and immune responses. The stressor is able to include an exposure to ionizing radiation. The effects of the stressors are able to be monitored in terms of changes in the chemical concentrations and chemical compositions in an exhaled breath. The chemicals are able to function as bio-markers. The chemicals that are to be monitored are able to include nitric oxide, carbon monoxide, carbon dioxide, ethane, and other molecules related to specific disease resulting from the stressor. | 02-10-2011 |
20110035159 | CORRECTING BIOLOGICAL SIGNAL MEASUREMENTS FROM PARALLEL MEASUREMENT DEVICES - A computer-implemented method and apparatus for correcting data sets from microarray measurements of gene expression values made with several different microarray versions. The method comprises obtaining data sets ( | 02-10-2011 |
20110040486 | Method for standardization of chemical and therapeutic values of foods and medicines using animated chromatographic fingerprinting - The present invention provides a method of standardization of chemical and therapeutic properties and quality of foods and medicines. The present invention provides a method of chromatographic finger printing facilitating correlation of traditional methods used for chemical and therapeutic standardization of medicines and humors in the living things with physico chemical properties of the medicines and their constituents. The method is used for the qualitative and quantitative analysis of the energy involved in the medicines and living things and to understand various bio chemical reactions in living things using an energy system. It provides a rational basis to understand the traditional methods of assessment of chemical and therapeutic qualities of materials used for the said purpose. The present invention also provides the influence, of factors like pH, temperature, viscosity and ionic nature of the media along with atomic and molecular properties indicating the chemical and therapeutic values of the foods and medicines of natural and synthetic nature. The analysis of biological samples like blood indicated the utility of the method for the assessment of clinical pathological conditions of healthy and diseased. This facilitates for a better drug discovery, drug monitoring, drug targeting and drug profiling using different features of 3-D animated energy box created after analyzing the sample by different analysis, separation and detection methods. | 02-17-2011 |
20110040487 | SUBSTANCE MONITORING AND CONTROL IN HUMAN OR ANIMAL BODIES - Apparatus for monitoring a substance in human or animal in real time, the apparatus comprising a sensor providing a time series of measurements of substance level, said measurements being indicative of an inferred level of said substance in a part of said human or animal and a processor which applies an interacting multiple model strategy to a system model to provide a combined estimate of the inferred substance level from the substance level measurements. The substance may be glucose. The apparatus may also be adapted to control said substance using said interacting multiple model strategy to a system model to provide a combined estimate of a dose to be applied. | 02-17-2011 |
20110040488 | SYSTEM AND METHOD FOR ANALYSIS OF A DNA SEQUENCE BY CONVERTING THE DNA SEQUENCE TO A NUMBER STRING AND APPLICATIONS THEREOF IN THE FIELD OF ACCELERATED DRUG DESIGN - The present invention relates to a system and a method for analysis of a DNA sequence by converting the DNA sequence into a unique number string using a genomic number system in order to extract and/or analyze biological information. The invention is particularly useful in the development of new drugs or active chemical agents. | 02-17-2011 |
20110040489 | Diabetes Care Host-Client Architecture and Data Management System - A host-client data sharing system manages diabetes care data. A host database, preferably web or internet based, is implemented for storing diabetes care data relating to multiple diabetics. A client or local database stores the diabetes care data relating to multiple diabetics on a personal appliance such as a PC, or a portable or handheld microprocessor-based computing device. The host database uses multiple servers for handling client interactions with the system. | 02-17-2011 |
20110040490 | PARAMETRIC SYSTEM FOR QUANTIFYING ANALYTE POLYNUCLEOTIDES - System for quantifying analyte polynucleotides employs computer-implemented analysis of real-time amplification data using a calibration curve defined by parametric equations. | 02-17-2011 |
20110040491 | CLASSIFICATION OF SAMPLE DATA - A classification system ( | 02-17-2011 |
20110040492 | SYSTEM AND METHOD FOR MEASURING PHASE RESPONSE CHARACTERISTIC OF HUMAN-BODY IN HUMAN-BODY COMMUNICATION - There is provided a system and a method for measuring phase response characteristic of a human body in human-body communication. The system and method may be useful to measure phase response characteristic of the human body without forming a common ground line between a reference signal transmitter and a reference signal receiver by transmitting a first reference signal through the human body and transmitting a second reference signal through the optical cable. | 02-17-2011 |
20110046887 | METHOD FOR ASSESSING PATHWAY PRODUCT LEVELS - This document relates to assessing homeostasis within mammals. For example, methods and materials for determining whether or not a biological system is functioning normally are provided. | 02-24-2011 |
20110046888 | METHOD OF DIAGNOSING TUMOR DISORDERS IN HUMANS - The invention is used for the diagnosis of human tumoral diseases. The diagnosis method consists of preparing films from patient arterial and venous blood, processing said films using a conventional method such as fixing or dyeing, measuring the surface areas of the arterial and venous blood lymphocyte nuclei and comparing said surface areas to corresponding cell surface areas of different lymphocyte groups, plotting regression lines for the arterial and venous blood according to the values thus obtained, determining the percentage thereof for each lymphocyte group, plotting the influence curve thereof in the form of a function of the diameter of corresponding lymphocyte groups, introducing weight factors whose quantity increases along the lymphocyte diameter decrease, multiplying said factors by the lymphocyte percentage, and plotting the sums' correspondence for the arterial and venous blood in the form of the function of the difference therebetween. The diagnosis, location of the tumor, and degree of advancement of the oncological process are jointly determined according to the intersection and correlation of the regression lines and according to characteristic pictures and areas of the curves obtained. | 02-24-2011 |
20110046889 | ENVIRONMENTAL MONITORING SYSTEM FOR CANINES, FELINES, OR OTHER ANIMALS - An apparatus for measuring, storing and communicating measurements of a dog, cat, other animal or inanimate object's environment. The apparatus may take the form of a collar, bridle, tag, harness or other mechanism worn by the animal or a device to be shipped with the animal or inanimate object. The apparatus may include mechanisms to initiate and terminate measurement and may include the ability to detect and report values exceeding specified limits. | 02-24-2011 |
20110046890 | Method for accurately determining concentrations of diffusible materials - The invention provides an improved microdialysis method for determining the free concentration of an agent or drug (defined as the concentration of agent that is dissolved and free to diffuse, and not undissolved or precipitated, complexed, bound, included in micelles or microemulsions, etc.). | 02-24-2011 |
20110046891 | CO-CRYSTALLIZATION OF ERR-alpha WITH A LIGAND THAT FORMS A REVERSIBLE COVALENT BOND - The crystal structure of the ligand binding domain of ERR-α in complex with a ligand that forms a reversible thioether bond to Cys325 of ERR-α, methods to measure dissociation rates for ligands that form reversible covalent bonds, and methods to design ligands that form reversible covalent bonds for use as modulators of ERR-α activity are disclosed. The crystal structure and methods provide a novel molecular mechanism for modulation of the activity of ERR-α and provide the basis for rational drug design to obtain potent specific ligands for use as modulators of the activity of this new drug target. | 02-24-2011 |
20110046892 | Method and Device for Utilizing Analyte Levels to Assist in the Treatment of Diabetes - A health-monitoring device assesses the health of a user based on levels of two analytes in a biological fluid. A first analyte that is utilized to assess a user's health is a fat metabolism analyte, such as ketones, free fatty acids and glycerol, which is indicative of fat metabolism. A second analyte that is utilized is a glucose metabolism analyte, such as glucose. The levels of the two analytes may be used to assess insulin sensitivity, to detect both recent hypoglycemia and the cause of high glucose levels, and/or to guide therapeutic intervention. The dual analyte model may calculate a discrepancy between an actual insulin activity level and a theoretical insulin activity level. The dual analyte model of the present invention may be used to identify individuals at risk for metabolic syndrome, insulin resistance and non-insulin dependent diabetes, and allows monitoring of the progression of those disease states, as well as progress made by therapeutic interventions. | 02-24-2011 |
20110046893 | METHOD FOR NORMALIZING THE RESULTS OF AN IN-VITRO ANALYTICAL METHOD - A method is disclosed for normalizing the results of an in-vitro analytical method for one or more diagnostically and/or prognostically relevant substances in an organism (biomarker) or one or more substances supplied to an organism from the outside. In at least one embodiment of the method a) one or more concentration values of the substance(s) in an organism, said concentration value(s) being obtained in an in-vitro analytical method is (are) provided, b) data obtained from an imaging study of the same organism are provided, c) from the data according to b), one or more quantitative values are determined as imaging value(s), d) from the values according to a) and c), one or more diagnostic parameters are determined by relating the values according to a) and c) to one another, and also to the use of this method for the type-correct dosage finding of drugs and for the in-vitro diagnosis, prognosis and monitoring the course of a disease. In addition, at least one embodiment of the invention relates to a program for a data processing system which, when carried out in a suitable computer system, carries out the above method, and also to an electronically readable data carrier having electronically readable control information stored thereon, which control information is configured in such a manner that they carry out the above method when a suitable data carrier is used in a suitable computer system. | 02-24-2011 |
20110046894 | METHOD FOR DISCRIMINATING BETWEEN MALIGNANT AND BENIGN TISSUE LESIONS - An embodiment of the present invention includes a method for discriminating between benign and malignant tissue lesions. The method includes the steps of using a plurality of maps of physiology and morphology parameters generated from reflectance measurements and pure morphology parameters generated from reflectance measurements. The method also includes calculating entropies and cross entropies of the plurality of maps, and calculating a plurality of pure morphology parameters. Further, the method includes assigning a weight to each entropy and a weight to a logarithm of each entropy, a weight to each cross entropy and a weight to a logarithm of each cross entropy, and a weight to each pure morphology parameter and a weight to a logarithm of each pure morphoiogy parameter. The method further includes computing a diagnostic index, defining a cost function, defining a proper threshold value for a diagnostic index and solving an optimization problem to determine a set of weights from the assigned weights to maximize specificity for 100% sensitivity. Further, the method uses calculations, the cost function and the diagnostic index to determine whether the tissue lesion is benign or malignant. | 02-24-2011 |
20110046895 | Method and Device for Utilizing Analyte Levels to Assist in the Treatment of Diabetes - A health-monitoring device assesses the health of a user based on levels of two analytes in a biological fluid. A first analyte that is utilized to assess a user's health is a fat metabolism analyte, such as ketones, free fatty acids and glycerol, which is indicative of fat metabolism. A second analyte that is utilized is a glucose metabolism analyte, such as glucose. The levels of the two analytes may be used to assess insulin sensitivity, to detect both recent hypoglycemia and the cause of high glucose levels, and/or to guide therapeutic intervention. The dual analyte model may calculate a discrepancy between an actual insulin activity level and a theoretical insulin activity level. The dual analyte model of the present invention may be used to identify individuals at risk for metabolic syndrome, insulin resistance and non-insulin dependent diabetes, and allows monitoring of the progression of those disease states, as well as progress made by therapeutic interventions. | 02-24-2011 |
20110054798 | FLOW CYTOMETER REMOTE MONITORING SYSTEM - Generally, a computer implemented remote monitoring system which generates a viewable reduced byte data representation for each one of a plurality of analyzed instrument signals. Specifically, a flow cytometer remote monitoring system which generates a viewable reduced byte data representation for each one of a plurality analyzed flow cytometer signals. | 03-03-2011 |
20110054799 | DEVICE FOR DETECTING AND DISPLAYING ONE OR MORE OF BODY WEIGHT, BODY FAT PERCENTAGE, BLOOD PRESSURE, PULSE AND ENVIRONMENTAL TEMPERATURE - A device for measuring and displaying body parameters includes a sensor that generates a signal representing a detected body parameter, such as body fat, body water and weight, of an individual; a transmitter to wirelessly transmit the signal; a receiver to receiver and display the sensed measurements as well as a user's name, time, date and temperature. The invention also pertains a method for determining fitness comprising the steps of: inputting, data pertaining to one of date, time, an individual's name, and fitness statistics, sensing parameters of one or more of an a body fat, a body a water and a weight; recording sensed parameters and said data; and transmitting the sensed parameters and said data; receiving said sensed parameters and said data and a signal proportional to a temperature and displaying one or more of said sensed parameters, data and temperature on a portable display unit. | 03-03-2011 |
20110060529 | TISSUE INHIBITOR OF MATRIX METALLOPROTEINASES TYPE-1 (TIMP-1) AS A CANCER MARKER - The present invention describes a method for determining whether an individual is likely to suffer from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual. | 03-10-2011 |
20110060530 | Analyte Signal Processing Device and Methods - Methods and devices for determining a measurement time period, receiving a plurality of signals associated with a monitored analyte level during the determined measurement time period from an analyte sensor, modulating the received plurality of signals to generate a data stream over the measurement time period, and accumulating the generated data stream to determine an analyte signal corresponding to the monitored analyte level associated with the measurement time period are provided. Systems and kits are also described. | 03-10-2011 |
20110060531 | BLOOD VOLUME MEASURING METHOD AND BLOOD VOLUME MEASURING APPARATUS - A blood volume measuring method includes: acquiring data of stroke volume variation at each respiratory rate, and storing the acquired data in a first buffer; reading an N1 number of the data stored in the first buffer, from the first buffer, and storing the N1 number of the data in a second buffer; excluding a part of the data stored in the second buffer, a value of each of which exceeds a first upper limit or falls below a first lower limit, from the data stored in the second buffer, and storing the other of the data stored in the second buffer, in a third buffer; acquiring a deviation of each of the data stored in the third buffer, from a median value of the data stored in the third buffer, excluding a part of the data stored in the third buffer, the deviation of each of which exceeds a second upper limit or falls below a second lower limit, from the data stored in the third buffer, and storing the other of the data stored in the third buffer, in a fourth buffer; determining whether N2/N1 is within an allowable value or not, wherein the N2 is a number of the data stored in the fourth buffer; and when it is determined that the N2/N1 is within the allowable value, calculating data of average stroke volume variation based on the data stored in the fourth buffer. | 03-10-2011 |
20110060532 | METHODS AND COMPOSITIONS FOR THE ASSESSMENT OF DRUG RESPONSE - The present invention provides methods for predicting or determining a subject's response to an antiplatelet agent, and methods for determining a subject's suitability to a treatment regime or intervention for a disease associated with platelet aggregation, using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's response to an antiplatelet agent. Nucleotide probes and primers, kits, and microarrays suitable for such assessment are also provided | 03-10-2011 |
20110066381 | METHOD AND APPARATUS FOR ARTIFACTS MITIGATION WITH MULTIPLE WIRELESS SENSORS - Certain aspects of the present disclosure relate to a technique for mitigating artifacts of biophysical signals in a body area network. Information from multiple sensors (including motion information of the body) can be employed in mitigating the artifacts. The biophysical signals in the body area network can be compressively sensed. | 03-17-2011 |
20110066382 | SYSTEMS AND METHODS FOR DETECTING NORMAL LEVELS OF BACTERIA IN WATER USING A MULTIPLE ANGLE LIGHT SCATTERING (MALS) INSTRUMENT - A particle detection system uses a camera to produce a picture based on the scattered light generated by a particle in a liquid medium, when a laser beam is incident on the particle. These pictures are then automatically analyzed through the use of a processing system (e.g., a computer). The processing system is configured to record the forward scattering intensity (e.g., amplitude) and the picture of the scattered light rays to generate a classification of the particle causing the scattering. Count rate and trends of the classified particles are monitored to detect a change that is representative of the overall health safety of the water or by knowing the levels of bacteria in process water, such as Reverse Osmosis (RO) feed water, reject brine, and product water, the operator may better monitor the life and condition of the RO membrane. | 03-17-2011 |
20110066383 | Indentifying One or More Activities of an Animate or Inanimate Object - Methods, systems and apparatus for identifying an activity of an animate or inanimate object are disclosed. One method includes identifying each elemental motion of a sequence of elemental motions of a device attached to the animate or inanimate object. The activity of the animate or inanimate object can be identified by matching the sequence of identified elemental motions of the device with a library of stored sequences of elemental motions, wherein each stored sequence of elemental motions corresponds with an activity. | 03-17-2011 |
20110066384 | Computer Aided Ligand-Based and Receptor-Based Drug Design Utilizing Molecular Shape and Electrostatic Complementarity - Methods related to the generation of shape signatures representing molecular shape, and using shape signatures in both ligand-based and receptor-based molecular design. Ray-tracing is used to explore the volume interior to a ligand, or the space exterior to a receptor site. Shape signatures are then probability distributions derived from the ray-traces. Shape signatures provide condensed descriptors of shape properties readily compared to each other to test for shape similarity or complementarity. | 03-17-2011 |
20110066385 | QUANTIFICATION OF DIFFERENCES BETWEEN MEASURED VALUES AND STATISTICAL VALIDATION BASED ON THE DIFFERENCES - A system and method of validating differences between measured values of fluorescence intensities obtained from a fluorescence-based instrument, including: generating calibration histograms for calibration beads run through the instrument; calibrating a distance function configured to measure distances between the histograms by: constructing a metric using the distance function, which includes a bin-to-bin dissimilarity matrix; and populating the dissimilarity matrix to maximize the following conditions: (A) the distance function of two histograms representing two sets of different beads equals the difference of their MESF values; and (B) the distance function of two histograms representing fluorescence of two sets of identical beads is zero; applying the metric to flow cytometry histograms generated for biological samples, to determine distances between the histograms; constructing a statistical test using the metric to determine a statistical significance of the distances; and determining whether the histogram results from the biological samples are reliable based on the statistical significance. | 03-17-2011 |
20110071764 | Biological Cell Sorting and Characterization Using Aerosol Mass Spectrometry - Among other things, methods, systems, apparatus for performing on-the-fly apportionment are described. In particular, spectrum data associated with a particle is acquired in real-time. The acquired real-time spectrum data is analyzing in real-time to classify the particle. Analyzing the data in real-time includes comparing the acquired spectrum data with a library of known mass spectral fingerprints to obtain a match. | 03-24-2011 |
20110071765 | Device and Method for Alleviating Postprandial Hyperglycemia - Embodiments of the present disclosure are directed to methods, systems and devices for alleviating postprandial hyperglycemia, as well as to methods and devices for sustained medical infusion of fluids, using, for example, skin securable insulin dispensing systems/devices. | 03-24-2011 |
20110071766 | METHOD AND SYSTEM FOR DETERMINING A THRESHOLD FOR SPIKE DETECTION OF ELECTROPHYSIOLOGICAL SIGNALS - A method is provided for determining a threshold ( | 03-24-2011 |
20110077869 | CIRCUIT FOR DETECTING ANALYTES VIA NANOPARTICLE-LABELED SUBSTANCES WITH ELECTROMAGNETIC READ-WRITE HEADS - A circuit for detecting antigens on biosample tracks comprising a processor, an electromagnetic write head for magnetizing nanoparticles attached to the antigens via antibodies in response to a write signal from the processor, and a first amplifier for supplying power to the write head. The circuit further comprises a magneto-resistive read sensor for detecting the magnetized nanoparticles upon receiving a read signal from the processor, and a second amplifier for supplying power to the read sensor. The write head and read sensor may be part of a head module in a magnetic tape drive. Nanoparticles of differing magnetic properties may be selectively paired with antibodies associated with different antigens to allow different antigens to be detected upon a single scan by the read-sensor. | 03-31-2011 |
20110077870 | BLOOD CELL COUNTER, DIAGNOSIS SUPPORT METHOD AND COMPUTER PROGRAM PRODUCT - A blood cell counter apparatus comprising: a detector for detecting blood cells in blood of a subject; and a controller for obtaining, based on a detection result by the detector, first analytical information about nucleated red blood cells in the blood, and second analytical information about granulocytes in the blood or third analytical information about platelets in the blood, and for outputting diagnosis support information for supporting prognosis of the subject, based on the first analytical information and on the second analytical information or the third analytical information that have been obtained. A method and computer program product are also disclosed. | 03-31-2011 |
20110082648 | Microchip blood analyzer - A microchip blood analyzer contains a mixing unit that mixes a sample and a test reagent with each other; a detection unit that detects a reaction of the mixture, a measurement unit that measures an amount of a specific ingredient in the sample; and a judgment unit that obtains a value using an approximate expression in a least-square method by using measurement data, compares a value obtained from an approximate expression and a value of the measurement data to obtain a deviation degree, and generates an output of a measurement result when the deviation degree is a prescribed value or greater. | 04-07-2011 |
20110087436 | METHOD AND SYSTEM FOR ANALYSIS OF TIME-SERIES MOLECULAR QUANTITIES - A method and system for analyzing a plurality of groups of time-series gene expressions including determining a time-dependent score that comprises a difference between the gene expression in the first group at a given time point and the gene expression in the second group at the given time point, determining an expected difference parameter that comprises a difference between a mean expression of the gene in a third group of samples and a mean expression of the gene in a fourth group of samples, created by randomly dividing the samples into two equal groups, comparing a difference between the time-dependent score and the expected difference parameter to a threshold at the given time point, determining the significant genes at each time point on the basis of the comparison. | 04-14-2011 |
20110087437 | PROCESS, SOFTWARE ARRANGEMENT AND COMPUTER-ACCESSIBLE MEDIUM FOR OBTAINING INFORMATION ASSOCIATED WITH A HAPLOTYPE - The present invention relates to a method, system and software arrangement for determining the co-associations of allele types across consecutive loci and hence for reconstructing two haplotypes of a diploid individual from genotype data generated by mapping experiments with single molecules, families or populations. The haplotype reconstruction system, method and software arrangement of the present invention can utilize a procedure that is nearly linear in the number of polymorphic markers examined, and is therefore quicker, more accurate, and more efficient than other population-based approaches. The system, method, and software arrangement of the present invention may be useful to assist with the diagnosis and treatment of any disease, which has a genetic component. | 04-14-2011 |
20110087438 | COMPUTER THAT WEIGHS - A system and method of using an adaptable interface for a medical device such as a scale. The scale includes a memory, a display, a processor, and a measurement component to measure one or more characteristics of a subject, such as height or weight. The adaptable interface includes a reconfigurable driver module that enables communication with different Electronic Health Record (“EHR”) systems. The interface can download new drivers or update drivers to reconfigure the driver module. The reconfigured driver module is then configured to communicate with an EHR system according to the particular EHR system communication protocol. The adaptable interface is modular and includes one or more mounting adapters to enable coupling to adjustable interface mounting assembly. The adjustable interface mounting assembly is also operable to receive other modular interface units. | 04-14-2011 |
20110087439 | SYSTEMS AND METHODS FOR IDENTIFYING MATERIALS UTILIZING MULTIVARIATE ANALYSIS TECHNIQUES - Described are a system and method for identifying a material. A spectrum is received. A barcode is generated from a sign of a second derivative of the spectrum. Multivariate data analysis tools and techniques are applied based on the barcode. The material is identified from results of the multivariate data analysis based on the barcode. | 04-14-2011 |
20110093204 | Methods and system for the identification and characterization of peptides and their functional relationships by use of measures of correlation - The invention provides methods and a system implementing these methods for identifying and characterizing peptides and their functional relationships by use of measures of correlation. These methods are based on the interaction of a Correlation Associated Network Module with several Application Modules including a Sequence Network Module, a Differential Network Module, a Marker Panel Network Module and a Surrogate Network Module allowing e.g. the provision of a representative overview of the peptide content of biological samples, the prediction of peptide sequences, the identification of peptides suitable to be used as marker panels and the identification of peptides suitable as surrogates for a known peptide. | 04-21-2011 |
20110093205 | PROTEOMICS PREVIEWER - A technique for analyzing proteomics data (such as tandem mass-spectrometry data) corresponding to peptides in a sample is described. In a high-speed, low-sensitivity first pass of this analysis technique, analysis parameters, such as the presence of one or more potential modifications to the one or more peptides, are determined using a representative subset of a database of known proteins. For example, a given potential modification in the one or more potential modifications may be determined by comparing matches between measured mass-spectrometry spectra and generated theoretical mass-spectrometry spectra without the given potential modification to matches between the measured mass-spectrometry spectra and generated theoretical mass-spectrometry spectra with the given potential modification. Then, in a lower-speed, higher-sensitivity second pass of the analysis technique, one or more peptides and/or proteins in the proteomics data are identified using the database of known proteins and the determined analysis parameters. | 04-21-2011 |
20110093206 | METHODS, SYSTEMS, AND PRODUCTS FOR QUANTITATIVELY MEASURING THE DEGREE OF CONCORDANCE BETWEEN OR AMONG MICROARRAY PROBE LEVEL DATA SETS - Methods, systems and products are provided to quantitatively measure the degree of concordance between or among microarray probe level data sets. These can include the steps of evaluating outlier probe values, determine gene expression scores, evaluating the significant treatment effect for each gene expression score, and determining concordance between replicate data sets | 04-21-2011 |
20110093207 | System for Conducting the Identification of Bacteria in Biological Samples - The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system. | 04-21-2011 |
20110093208 | LEAST-SQUARE DECONVOLUTION (LSD): A METHOD TO RESOLVE DNA MIXTURES - Least Square Deconvolution (LSD) uses quantitative allele peak data, for example, allele peak area, allele peak height and optical density, derived/obtained from a sample containing the DNA of more than one contributor to resolve the best-fit genotype profile of each contributor. The resolution is based on finding the least square fit of the mass ratio coefficients at each locus to come closest to the quantitative allele peak data. Consistent top-ranked mass ratio combinations from each locus can be pooled to form at least one composite DNA profile at a subset of the available loci. The top-ranked DNA profiles can be used to check against the profile of a suspect or be used to search for a matching profile in a DNA database. | 04-21-2011 |
20110093209 | METHODS AND SYSTEMS FOR SIMULTANEOUS ALLELIC CONTRAST AND COPY NUMBER ASSOCIATION IN GENOME-WIDE ASSOCIATION STUDIES - Methods and systems are provided for performing allelic copy number association in genome-wide association studies. Also provided are computer-readable media for storing instructions for performing the genomic marker association studies. The methods include performing genomic marker association studies wherein allelic contrast and copy number are analyzed simultaneously, comprising the steps of receiving measurements of intensity for each of two alleles (A and B) in a biological sample set; computing a sum value (S) and a difference value (D) of the intensities; and employing a statistical model to determine a potential association of the S and/or the D value with an outcome, wherein a statistically significant coefficient of the S intensity indicates an association of the copy number with the outcome and a statistically significant coefficient of the D intensity indicates an association of the allelic contrast with the outcome. | 04-21-2011 |
20110093210 | MEASUREMENT DEVICE AND METHOD OF CONTROLLING THE SAME - A measurement device includes: a first measurement unit ( | 04-21-2011 |
20110093211 | Method for Processing Protein Data - A method of generating data indicating whether a set of proteins is a protein complex. The method comprises receiving as input experimental data indicating experimentally observed relationships, each experimentally observed relationship being between a first protein and zero or more second proteins and generating data indicating whether the set of proteins is a protein complex. The experimental data is processed to determine a first data value indicating a number of proteins having a relationship with one or more second proteins and a second data value indicating a number of proteins having a relationship with a selected protein. | 04-21-2011 |
20110098933 | Systems And Methods For Processing Oximetry Signals Using Least Median Squares Techniques - Methods and systems are disclosed for determining information from a signal using least median squares techniques, including determining blood oxygen saturation measurements based at least in part on photoplethysmograph signals. In an embodiment, a Lissajous figure is generated based on multiple measurements and least median squares techniques may be used for one or more of: determining information, assessing measurement confidence, filtering measurements, and choosing a regression analysis technique. | 04-28-2011 |
20110098934 | Method and Apparatus for Measuring Data for Injury Analysis - An apparatus as provided for measuring acceleration of a person's head or other object. The apparatus comprises a sensor for sensing acceleration and a controller for controlling recording of data resulting from the sensed acceleration due to an explosive force. The controller is adapted to determine whether or not to enable recording of the data based on the sensed acceleration. A data receiver is provided to receive the sensed acceleration data from the sensing means, and requires electrical power to enable data to be received thereby. The controller controls electrical power to the receiver so that if the sensed acceleration reaches or exceeds a predetermined value, electrical power to the data receiver is enabled. The recorded acceleration data may be used for injury analysis. | 04-28-2011 |
20110098935 | TECHNIQUES FOR DETERMINING THE EFFECTS ON A SYSTEM OF A COMPONENT THAT HAS FOUR STATES - Techniques for determining effects on a biological system include determining rate constants for a particular time interval starting at an initial time. Each rate constant indicates a rate of transition from one of four states to a different one of the four states for a component of a biological system in presence of an external factor. A temporal change in a probability that the component is in a particular state after the initial time is determined without numerical iteration over multiple time steps. This includes determining three relaxation time constants that describe exponential changes based on the rate constants. The effect of the external factor on the biological system is determined based on the temporal change in the probability that the component is in the particular state. The probability at an arbitrary time is determined based on the rate constants and initial probabilities. | 04-28-2011 |
20110106453 | Method for storing a series of measurements - A method reducing storage volume of a series of measured time-dependent parameters measured in or on the human body such as glucose values from a continuous glucose monitor while permitting retrospective reconstruction of measured data with sufficient accuracy. The series comprises a first number of measured values, and a second number of values that are stored. In this case, the second number is smaller than the first number. A first storage mode is provided, in which an interval of time between successive stored values is variable and which is adjusted on the basis of a time-based variability of the measured values. A second storage mode may also be provided, in which the interval, of time between successive stored values is constant. Embodiments of the invention include a measuring apparatus and a computer program. | 05-05-2011 |
20110112770 | VEHICLE EVALUATION METHOD AND VEHICLE EVALUATION APPARATUS - The vehicle evaluation method and vehicle evaluation apparatus can appropriately and quantitatively evaluate the sense of lateral oscillation of a vehicle. The method and apparatus measure muscle activity waveforms of a pair of left and right muscles in at least one type of skeletal muscle involved in maintaining a posture of a head of an occupant of the vehicle driven under predetermined driving conditions, calculate an amount of simultaneous activity that expresses characteristics of the muscle activity waveforms and evaluate a sense of lateral oscillation of the vehicle based on the amount of simultaneous activity. | 05-12-2011 |
20110112771 | Wearable sensor system with gesture recognition for measuring physical performance - A wearable sensor system with gesture recognition for measuring physical performance | 05-12-2011 |
20110118986 | METHODS AND APPARATUS FOR EVALUATING GLUCOSE LEVELS AROUND A REPEATING EVENT - Methods for evaluating changes in glucose levels include selecting a repeating event, obtaining a pre-event measurement and a post-event measurement for a plurality of occurrences of the repeating event wherein a glucose change between the pre-event measurement and post-event measurement may be determined for each of the plurality of occurrences of the repeating event, and, recording unique details for each of the plurality of occurrences of the repeating event such that the unique details may be correlated with the glucose change for each of the plurality of occurrences of the repeating event. | 05-19-2011 |
20110118987 | PREDICTIVE BLOOD SUGAR LEVEL CALCULATING DEVICE, PREDICTIVE BLOOD SUGAR LEVEL CALCULATING METHOD, AND PROGRAM THEREOF - A predictive blood sugar level calculating device acquires meal information about meal intake, calorie consumption information about calorie consumption, pulse information, and the like, calculates predictive blood sugar level change curves indicating change in blood sugar levels based on the plurality of information in a time series using predetermined numerical formulas, and combines the predictive blood sugar level change curves, thereby reducing an error between the calculated predictive blood sugar level curve and an actual change in a blood sugar level occurring in a human body. | 05-19-2011 |
20110125408 | Thermoelectric biosensor for analytes in a gas - A biosensor for detecting at least one analyte in a gas includes a capture apparatus, a thermoelectrical sensor, and a microprocessor attached to the first ends of a first lead and a second lead, the two leads having second ends attached to the two contact pads of a thermopile whose difference is converted to concentration of the analyte and shown on an electronic display. The thermoelectrical sensor has a layer of at least one interactant, at least one thermopile and an insulator. The interactant with the analyte produces or consumes heat which is transferred to the thermopile which develops a voltage difference that causes the microprocessor to convert the voltage an indication of the analyte. | 05-26-2011 |
20110125409 | MEASURING AND ANALYZING MULTI-DIMENSIONAL SENSORY INFORMATION FOR IDENTIFICATION PURPOSES - Methods and systems are provides for measuring multi-dimensional sensing information for identification purposes. The identity of one or more substances is determined through analysis of multidimensional data that can include, among others, intrinsic information as well as extrinsic information. The method for identification of a substance comprises utilizing pattern recognition to form descriptors to identify characteristics of the substance. A system and computer program for performing analysis of the multidimensional data are also described. | 05-26-2011 |
20110125410 | SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms. | 05-26-2011 |
20110130968 | Method for computing ligand - host binding free energies - Methods and systems for computing the binding free energy of a ligand to a host are disclosed. The method entails selecting random poses of a ligand, including translation, rotation, and conformation, and computing the ligand-host interaction energy. The poses are accepted or rejected based on the Metropolis criteria. The entropies of interaction are estimated from the log of the ratio of accepted poses to attempted poses. The free energy of the entire sampling region, and of sub-regions of the binding region, can be accumulated by storing the energies and acceptance ratios for both the entire region and the sub regions. In order to better shape the protein to the ligand, energy minimization of the host atoms in the region of the ligand is carried out in the presence of the lowest free-energy pose of the ligand, optionally preceded by random perturbation of the Cartesian coordinates of the host atoms in the vicinity of the ligand. | 06-02-2011 |
20110130969 | Resonant-Wavelength Measurement Method For Label-Independent Scanning Optical Reader - A method of measuring a resonant wavelength of a resonant waveguide (RWG) biosensor in an array of RWG biosensors supported by a microplate in a label-independent optical reader is disclosed. An exemplary method includes scanning a light spot over the RWG biosensor to obtain a plurality of spectra from both a central portion and at least one edge portion of the RWG biosensor. The method includes calculating a weighted-average spectrum for the biosensor by averaging the plurality of spectra while applying greater weight to the central portion than to the at least one edge portion. The method includes determining the resonant wavelength from the weighted-average spectrum. The resulting resonant wavelength measurement has substantially reduced noise and provides improved performance for label-independent scanning optical reader systems that use scanned optical beams. | 06-02-2011 |
20110130970 | SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms. | 06-02-2011 |
20110130971 | SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms. | 06-02-2011 |
20110130972 | DEVICE FOR MEASURING CONSUMPTIONS AND THE RESPECTFUL PERFORMANCE WITH THE ENVIRONMENT - A device for measuring power consumption and performance relative to the environment of a power-consuming unit is disclosed. The device includes a data introduction module, a keyboard for inputting data of waste production in the power-consuming unit, a computing device, and a display screen. The computing device receives the data from the data introduction module and the keyboard. The computing device is also provided with a processor that includes a calculation algorithm of an ecological parameter indicative of the performance relative to the environment of the power-consuming unit. The ecological parameter is calculated as an adjusted mean of the sum of the deviations of each power consumption value with respect to a reference value. | 06-02-2011 |
20110137570 | METHODS FOR STRUCTURAL ANALYSIS OF GLYCANS - The invention relates to methods useful for the structural analysis of glycans. Methods are disclosed for sequencing glycans using stepwise disassembly processes by analysis of the fragments produced therein. Methods are additionally provided for identifying MS | 06-09-2011 |
20110137571 | METER HAVING MULTI-LEVEL USER INTERFACE - A meter adapted to determine and store an analyte concentration reading, in particular a glucose concentration reading, and including an interface having a plurality of predefined levels of user features. The predefined levels may be selected by a user based on the user's preferences, needs and abilities. | 06-09-2011 |
20110144914 | BIOMARKER ASSAY FOR DIAGNOSIS AND CLASSIFICATION OF CARDIOVASCULAR DISEASE - The disclosed methods, assays and kits identify biomarkers, particularly miRNA and/or protein biomarkers, for assessing the cardiovascular health of a human. In certain embodiments, methods, assays and kits, circulating miRNA and/or protein biomarkers are identified for assessing the cardiovascular health of a human. | 06-16-2011 |
20110144915 | FILL SUFFICIENCY METHOD AND SYSTEM - Described and illustrated herein are one exemplary method and a measurement system having a meter and a test strip. The test strip has a first working electrode, reference electrode and second working electrode. In this method, acceptable fill data from known first current and known second current are used to predict an estimated second current at proximate the second time period (for a given batch of test strips) during the test sequence. The estimated second current at proximate the second time interval is then compared with a measured actual second current at proximate the second time interval during an actual test to determine if the measured actual second current is substantially equal to or within an acceptable percent deviation from the estimated second current so as to determine sufficient volume of a physiological fluid sample in the test strip. | 06-16-2011 |
20110144916 | COMPUTER METHOD AND APPARATUS FOR CLASSIFYING OBJECTS - A computer classification method and apparatus employs statistical analysis of known objects in the class of interest. For each known object in the class, a respective vector of q bits is formed. Each bit indicates presence or absence of an activity or physical property in the object. The probability that a bit is equal to 1 in the class is then applied to vector representations of test objects and determines probability of the test object belonging, to the class. | 06-16-2011 |
20110144917 | SYSTEM AND METHOD FOR IDENTIFICATION OF SYNERGISTIC INTERACTIONS FROM CONTINUOUS DATA - Systems and methods for selecting factors from a continuous data set of measurements are provided. The measurements include values of factors and/or outcomes. Two or more factors that are jointly associated with one or more outcomes from the data set are identified. Each of the two or more factors are analyzed to determine at least one cooperative interaction among the factors with respect to an outcome. The two or more factors can be a module of factors serving as a single factor participating in a cooperative interaction with another factor or module of factors. | 06-16-2011 |
20110144918 | BIOLOGICAL INFORMATION DISPLAY DEVICE, BIOLOGICAL INFORMATION DISPLAY SYSTEM, STATISTICAL PROCESSING METHOD, AND RECORDING MEDIUM RECORDING THEREON STATISTICAL PROCESSING PROGRAM - A biological information display device displays measurement results for a plurality of times, for example, as result information on first measurement results for a plurality of times (S | 06-16-2011 |
20110144919 | BIOMARKER NORMALIZATION - A fluid sample is measured with a tear film measuring system that includes a processing device that receives a sample chip comprising a sample region configured to contain an aliquot volume of sample fluid, the processing device configured to perform analyses of osmolarity and of one or more biomarkers within the sample fluid, wherein the analysis of biomarkers includes normalization of biomarker concentration values. | 06-16-2011 |
20110144920 | METHOD, SYSTEM AND DEVICE FOR ENHANCING FLOW FIELD DATA - A method, system and device are described for generating high-resolution flow-field data from sparse measurement data by interpolating from a reference database of pre-computed, highly-resolved fluid dynamic simulation results, to generate a highly-resolved set of flow field data which correspond to the sparse measurements. In one embodiment, the method, system and device use Principal Component Analysis techniques to interpolate the multidimensional fluid flow data. Applications of the invention are, amongst others, in the field of biomedical diagnosis involving fluid dynamic modeling of biological fluid systems such as blood flow in an artery. | 06-16-2011 |
20110153220 | PROCESSING OF BIOLOGICAL GROWTH MEDIA BASED ON MEASURED MANUFACTURING CHARACTERISTICS - This disclosure is directed to information management techniques that may be used during automated processing of biological growth media. In one embodiment, a method comprises reading an identification element associated with a biological growth medium, identifying manufacturing information associated with the biological growth medium based on the identification element, wherein the manufacturing information includes one or more manufacturing variables measured from the biological growth medium when the biological growth medium was manufactured, adjusting one or more processing parameters associated with processing of the biological growth medium based on the manufacturing variables measured from the biological growth medium when the biological growth medium was manufactured, and processing the biological growth medium in an automated system based on the processing parameters. | 06-23-2011 |
20110153221 | DIAGNOSTIC SYSTEM FOR SELECTING NUTRITION AND PHARMACOLOGICAL PRODUCTS FOR ANIMALS - An analysis of the profile of a non-human animal comprises: a) providing a genotypic database to the species of the non-human animal subject or a selected group of the species; b) obtaining animal data; c) correlating the database of a) with the data of b) to determine a relationship between the database of a) and the data of b); c) determining the profile of the animal based on the correlating step; and d) determining a genetic profile based on the molecular dietary signature, the molecular dietary signature being a variation of expression of a set of genes which may differ for the genotype of each animal or a group of animals Nutrition and pharmalogical assessments are made. Reporting the determination is by the Internet, and payment for the report is obtained through the Internet. | 06-23-2011 |
20110153222 | OPTIMIZED PROBE SELECTION METHOD - The present invention provides methods for optimizing oligonucleotide hybridization probes for use in basic and clinical research. Specifically, the invention involves hybridizing serially diluted genomic sample to the oligonucleotide probes on the array, such that a signal intensity is produced for each of the probes; computationally identifying optimized probes which exhibit signal intensities that correspond to the serial dilutions of genomic sample and are reproducibly strong relative to non-optimized probes. | 06-23-2011 |
20110161011 | COMPUTER-ACCESSIBLE MEDIUM, SYSTEM AND METHOD FOR ASSESSING EFFECT OF A STIMULUS USING INTERSUBJECT CORRELATION - Exemplary embodiments of a system and method can be provided for measuring a level and/or details of how engaging, effective or memorable a stimulus that may be based on information associated with one or more subjects' neuronal, physiological and/or behavioral responses to the stimulus. In addition, an exemplary embodiment of a computer-accessible medium containing executable instructions thereon can also be provided which can be executed by a processing arrangement. For example, when the processing arrangement executes the instructions, the processing arrangement can be configured to, e.g., receive neuronal, physiological and/or behavioral data one or more subjects being presented with stimuli, determine further data associated with a measure of inter-subject similarity of the neuronal, physiological and/or behavioral data, and identify particular portions of the stimuli that meet a pre-determined criteria relating to the further data associated with the measure of inter-subject similarity. In addition, the processing arrangement can be further configured to display and/or store identifiers of the particular portions of the stimuli in a storage arrangement in a user-accessible format and/or a user-readable format. | 06-30-2011 |
20110161012 | READERS AND COMPUTER PROGRAM PRODUCTS THAT COOPERATE WITH SINGLE-USE EXTERNAL DOSIMETERS FOR USE IN RADIATION THERAPIES - Methods, systems, devices, and computer program products include positioning single-use radiation sensor patches that have adhesive means onto the skin of a patient to evaluate the radiation dose delivered during a treatment session. The sensor patches are configured to be minimally obtrusive and operate without the use of externally extending power cords or lead wires. | 06-30-2011 |
20110161013 | METHOD FOR DETERMINING HEAT BOUNDARY VALUE CONDITIONS OF RED BLOOD CELLS IN THE NEIGHBORHOOD OF MYOCARDIUM - A computer-implemented method for determining heat boundary value conditions of red blood cells neighboring a myocardium pertaining to the left ventricle of a heart. The method comprises dividing the myocardium into a plurality of myocardial samples wherein, each sample comprises a plurality of myocardial surfaces. The method further comprises quadratically representing each myocardial surface at apical, mid, and basal positions wherein the apical and basal positions are the positions at which the contraction of the heart begins and ends during systole. Further, parameterized forms of lines along x-y, x-z, and y-z axes are formulized; the parameterized forms of lines within which each myocardial surface at each position moves. Upon formulizing the parameterized forms of lines, the radial, longitudinal, and circumferential components of the magnitude of heat generated or lost at each myocardial surface at each position are obtained, following which, the radial, longitudinal, and circumferential components of the magnitude of heat transferred from each myocardial surface at each position to the red blood cells in the corresponding neighborhood are obtained. | 06-30-2011 |
20110166791 | METABOLIC MONITORING, A METHOD AND APPARATUS FOR INDICATING A HEALTH-RELATED CONDITION OF A SUBJECT - An apparatus for indicating a health-related condition of a subject has an input interface for receiving a sequence of samples of a first biological quantity derived by a first measurement method, the first measurement method being an invasive measurement and having a first impact on the subject, and for receiving a sequence of samples of a second biological quantity derived by a second measurement method, the second measurement method being a non-invasive measurement and having a second impact on the subject, wherein the first biological quantity gives a more accurate indication of the health-related condition of the subject than the second biological quantity, wherein the first biological quantity and the second biological quantity have a correlation to the health-related condition of the subject, and wherein the second impact is smaller than the first impact; a predictor for providing, for a certain time, for which no sample for the first biological quantity exists, an estimated value of the first biological quantity using samples for the first biological quantity and, as far as available, samples for the second quantity; and an output interface for outputting the estimated value or data derived from the estimated value so that an indication for the health-related condition of the subject is obtained. | 07-07-2011 |
20110166792 | INSULIN RESISTANCE EVALUATION SUPPORTING SYSTEM, INSULIN RESISTANCE EVALUATION SUPPORTING METHOD, AND COMPUTER PROGRAM PRODUCT - The present invention provides an insulin resistance evaluation supporting system, an insulin resistance evaluation supporting method, and a computer program product that can reduce the burden on a subject necessary to estimate biological information relating to the insulin resistance compared with that in conventional examples. An insulin resistance evaluation supporting system | 07-07-2011 |
20110166793 | METHOD AND APPARATUS FOR DETERMINING ANIMAL RELATIONSHIPS - A system and method of determining a relationship between a first animal ( | 07-07-2011 |
20110172925 | Secondary Structure Defining Database And Methods For Determining Identity And Geographic Origin Of An Unknown Bioagent Thereby - The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity. | 07-14-2011 |
20110172926 | Generating, viewing, interpreting, and utilizing a quantitive database of metabolites - This disclosure provides methods for the creation of a quantitative database of metabolites, particularly lipid metabolites, using chromatographic technology; methods for assembling that information into a visual format for interpretation, and methods of this information to identify and understand metabolome-wide effects, for instance those effects influenced by pharmaceuticals, genes, toxins, diet or the environment. Also provided are metabolite databases, such as lipid metabolite databases, that are stored on a computer readable medium, which include quantitative measurements of a plurality of metabolites. | 07-14-2011 |
20110172927 | AUTOMATED ADJUSTMENT OF POSTURE STATE DEFINITIONS FOR A MEDICAL DEVICE - Techniques relate to operating a medical device by classifying a detected posture state of a patient. This classification may be performed by comparing the detected posture state of the patient to posture state definitions available within the system. Each definition may be described in terms of a parameter (e.g., vector) indicative of a direction in three-dimensional space. The posture state definitions may be calibrated by automatically estimating values for these parameters, thereby eliminating the need for the patient to assume each posture state during the calibration process to capture actual parameter values. According to another aspect, the estimated parameter values may be updated as the patient assumes various postures during a daily routine. For instance, estimated vectors initially used to calibrate the posture state definitions may be changed over time to more closely represent posture states the patient actually assumes, and to further adapt to changes in a patient's condition. | 07-14-2011 |
20110172928 | MOLECULAR MARKERS FOR CANCER PROGNOSIS - The present invention relates to methods for prediction of an outcome of neoplastic disease or cancer. More specifically, the present invention relates to a method for the prediction of breast cancer by determining in a biological sample from said patient an expression level of a plurality of genes selected from the group consisting of ACTG1, CA12, CALM2, CCND1, CHPT1, CLEC2B, CTSB, CXCL13, DCN, DHRS2, EIF4B, ERBB2, ESR1, FBXO28, GABRP, GAPDH, H2AFZ, IGFBP3, IGHG1, IGKC, KCTD3, KIAA0101, KRT17, MLPH, MMP1, NAT1, NEK2, NR2F2, OAZ1, PCNA, PDLIM5, PGR, PPIA, PRC1, RACGAP1, RPL37A, SOX4, TOP2A, UBE2C and VEGF. | 07-14-2011 |
20110178716 | Method for determining volume and hemoglobin content of individual red blood cells - Provided herein is a method for determining the volume or hemoglobin content of an individual red blood cell in a sample containing a population of red blood cells. The method may be performed on a hematology analyzer. Also provided are a hematology analyzer for performing the method and a computer-readable medium containing programming for performing the method. | 07-21-2011 |
20110178717 | Diabetes Care Host-Client Architecture and Data Management System - A host-client data sharing system manages diabetes care data. A host database, preferably web or internet based, is implemented for storing diabetes care data relating to multiple diabetics. A client or local database stores the diabetes care data relating to multiple diabetics on a personal appliance such as a PC, or a portable or handheld microprocessor-based computing device. The host database uses multiple servers for handling client interactions with the system. | 07-21-2011 |
20110178718 | CHARACTERIZATION OF BIOLOGICAL SAMPLES - A method of characterizing a biological sample comprising separating the biological sample into constituents; observing the separated constituents; applying statistical classification modeling to the observed constituents; deriving quantifiable data from the applied statistical classification modeling; and analyzing the data from the applied statistical classification modeling to assess a donor of the biological compounds' health. A system for characterizing a biological sample comprising a biological sample separator, wherein the biological sample separator functions to separate the biological sample into constituents; a constituent observer, wherein the constituent observer functions to confirm and qualify the presence of the constituent; a constituent statistical processor, wherein the constituent statistical processor functions to apply statistical classification modeling to the observed constituent to derive representative data; and a statistical analyzer, wherein the statistical analyzer functions to compare the representative data to benchmark values to derive a predictor for a health concern. Also disclosed is a method comprising identifying a disease of interest; identifying one or more organisms having the disease of interest; obtaining one or more biological samples from the organisms having the disease of interest; identifying one or more characteristics of the biological samples; providing quantifiable data that represents the characteristics of the biological sample; and employing a statistical classification method that utilizes the quantifiable data to identify one or more discriminant directions wherein the discriminant directions relate the characteristics of the biological sample to the disease of interest. | 07-21-2011 |
20110178719 | Methods for Allele Calling and Ploidy Calling - Disclosed herein is a system and method for making allele calls, and for determining the ploidy state, in one or a small set of cells, or where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed and the haplotypes are determined using expected similarities between the target genome and the knowledge of the genomes of genetically related individuals. In one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the genetic data from both parents, and possibly one or more sperm and/or sibling embryos. In another embodiment, the chromosome copy number can be determined using the same input data. In another embodiment, these determinations are made for embryo selection during IVF, for non-invasive prenatal diagnosis, or for making phenotypic predictions. | 07-21-2011 |
20110178720 | METHOD AND SYSTEM FOR MEASURING ENERGY EXPENDITURE AND FOOT INCLINE IN INDIVIDUALS - A method and system for measuring energy expenditure of individuals by measuring force from a plurality of foot-borne force sensitive resistors and calculating incline from a foot-borne tri-axial accelerometer. | 07-21-2011 |
20110178721 | MEANS AND METHODS FOR DETECTING ANTIBIOTIC RESISTANT BACTERIA IN A SAMPLE - The present invention provides a method for detecting and/or identifying specific bacteria within an uncultured sample, comprising steps of: a. obtaining an absorption spectrum (AS) of said uncultured sample; b. acquiring the n dimensional volume boundaries for said specific bacteria; c. data processing said AS; i. noise reducing; ii. extracting m features from said entire AS; iii. dividing said AS into several segments according to said m features; iv. calculating m | 07-21-2011 |
20110184648 | METHODS AND APPARATUS FOR PERFORMING RETENTION-TIME MATCHING - A method for matching a precursor ion with one or more related product ions includes providing input data sets obtained from sample injections, each of the data sets including a precursor ion and one or more product ions, normalizing the input data sets in accordance with a single retention time for the precursor ion, determining which product ions are within a predetermined retention time window with respect to the single retention time, and, if a product ion is within the predetermined retention time window for a specified number of the input data sets, determining that the product ion is related to the precursor having the single retention time. An apparatus for analyzing a sample includes a chromatography module, a mass-spectrometry module in communication with the chromatography module, and a control unit in communication with the chromatography module and the mass-spectrometry module. | 07-28-2011 |
20110184649 | Method of Assessing Risk in an Area - A method and system for the evaluation of the probability for the presence of suspicious materials is presented. The proposed system will be able to continuously monitor a large area or a gate passage, without a specific need for a manual full-body search or manual inspection or the use of sniffers or sniffing dogs (although the system can be embedded within such a gate), and will allow to detect suspicious materials, not by identifying the specific material, but rather by at least one of the chemical and/or physical analysis of the commonality of all detected materials against the statistical accumulation database of all material properties that were presented to the system in the past. | 07-28-2011 |
20110184650 | UTILITY AND METHOD FOR THE APPLICATION OF SIGNAL ADVANCE AMPLIFICATION TO ANALOG WAVEFORM OR SIGNAL DETECTION, ACQUISITION AND PROCESSING - An analog waveform signal detection/data acquisition system that is based on negative group delay for reducing inherent delay in analog waveform or signal detection and acquisition and facilitating earlier than otherwise possible responsive actions to analog waveform data. Signal advance amplification and data conditioning reduces distortion and permits greater temporal advance than previously possible. | 07-28-2011 |
20110184651 | ELECTRONIC ASSAY APPARATUS AND METHOD THEREOF - The present invention related to an electronic assay apparatus and a testing method thereof for increasing efficiency and saving power. The electronic assay apparatus for determining a result of an assay performed using a test strip comprises two light sources, one detector and a microprocessor. The two light sources respectively illuminate light incident upon a test zone or a control zone of a test strip. The only one detector disposed between the two light sources and detects light reflected from the test zone and the control zone alternately. The microprocessor compares a calculating result value to only one threshold for showing a result. | 07-28-2011 |
20110184652 | METHODS OF GENERATING GENETIC PREDICTORS EMPLOYING DNA MARKERS AND QUANTITATIVE TRAIT DATA - A genetic trait predictor is generated by blending individual molecular estimates with estimates of at least one genetic value derived from quantitative trait measure. The individual molecular estimates may include molecular trait estimates or molecular trait variance. The individual molecular estimates may be determined by applying individual deoxyribonucleic acid (DNA) markers, DNA marker panels, specific parameter estimates and specific parameter variance thereof, and a genotype of a test sample. Quantitative trait measure may include estimated breeding data, raw trait data, and breed composition data. The genetic predictor is accurate and stable under a wide range of conditions and relatively immune to errors in parameter estimation. | 07-28-2011 |
20110184653 | ANALYTE TESTING METHOD AND SYSTEM - Various methods and systems to manage diabetes using data relating to testing compliance, bolus dosing, or cannula usage are described and illustrated. | 07-28-2011 |
20110184654 | Means and Methods for Detecting Bacteria in an Aerosol Sample - This disclosure provides a method for detecting and/or identifying uncultured bacteria. The sample is an aerosol sample selected from a group consisting of cough, sneeze, saliva, mucus, bile, urine, vaginal secretions, middle ear aspirate, pus, pleural effusions, synovial fluid, abscesses, cavity swabs, serum, blood and spinal fluid. The method comprises obtaining absorption spectra (AS) of the sample, extracting and processing the acquired data, thereby detecting and/or identifying the bacteria. | 07-28-2011 |
20110184655 | NUMBER CODING FOR IDENTIFICATION OF SUBTYPES OF CODED TYPES OF SOLID PHASE CARRIERS - Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers which provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the bases of a different code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, to determine whether a sample is homozygous or heterozygous at a number of different sites for one of two different alleles, where the same color code is applied for each of the two alleles, and the alleles with the same color code are distinguished by knowing how many carriers are associated with molecules which detect each different allele. | 07-28-2011 |
20110184656 | Efficiently Determining Condition Relevant Modifiable Lifestyle Attributes - A bioinformatics method, software, system and database are presented in which attribute profiles containing pangenetic and non-pangenetic information are created and used to identify sets of attributes, including lifestyle attributes that are associated with a condition. The lifestyle attributes which can be modified and which result in a significant change in the probability of having the condition are identified and used as the basis for recommendations for lifestyle modification. | 07-28-2011 |
20110196614 | BLOOD TRANSCRIPTIONAL SIGNATURE OF MYCOBACTERIUM TUBERCULOSIS INFECTION - The present invention includes methods, systems and kits for distinguishing between active and latent | 08-11-2011 |
20110196615 | Processing of biological signals - A method processes a signal by storing a template sequence composed of a number N of consecutive digital samples of the signal; calculating a sequence of extended sums that includes, for each digital sample, an extended sum of absolute values of differences between N most recent digital samples and the samples of the template sequence; detecting minima of the sequence of extended sums; and estimating a period of the signal as a time interval between two consecutive minima of the sequence of extended sums. The method also estimates the noise level of the signal as a ratio between most recently-detected minimum and maximum of said sequence of extended sums. The method also generates a reduced-noise replica of the signal as a weighted average of the template sequence and of the current samples of the signal processed between two consecutive minima of said extended sum, the weighted average being calculated using weights based on the estimated noise level. | 08-11-2011 |
20110196616 | APPARATUS FOR AND METHOD OF MEASURING PERCEIVED AGE - This invention relates to an apparatus for and a method of measuring skin glow and/or skin radiance and/or skin shine and/or the biological age of the skin of an individual. | 08-11-2011 |
20110196617 | REMOVABLE HANDHELD UNIT - A measuring device including a sensor that generates data representing a detected body parameter, such as body fat, body water and weight of an individual. A portable device removably connected to the measuring device for receiving, displaying and storing the data representing the detected body parameter. The portable device may correlate the stored data with an individual user. The portable device is responsive to a personal computer for uploading the stored information thereto. | 08-11-2011 |
20110196618 | METHOD FOR VERIFYING POSITION ON AN ANGIOPLASTY BALLOON - A monitoring system and data archive system for a stent crimping process. The information concerning the crimped stent is used in deciding whether the stent is acceptable for insertion into the body cavity of a human or animal. | 08-11-2011 |
20110196619 | METHOD FOR PREDICTING BIOLOGICAL RHYTHM - There is provided a method that achieves the prediction of a biological rhythm with high precision while minimizing the number of times a biological specimen is collected from a subject. There is also provided a method for predicting a biological rhythm of a subject on the basis of time series expression level data obtained by measuring expression levels of two clock genes in biological specimens collected from the subject three times within 24 hours, the clock genes having different phases of circadian cycles of a change in expression levels. In this method for predicting a biological rhythm, a biological rhythm can be predicted with particularly high precision by collecting a biological specimen from a subject three times within 24 hours at eight-hour intervals. | 08-11-2011 |
20110202279 | METHOD AND SYSTEM FOR TRAIT EVALUATION THROUGH QUANTITATIVE GENOTYPING - Method for determining in a mixed population of biological organism percentage of individuals originated from two or more contributing populations by quantitative genotyping of the mixed population or samples thereof, without the need to identify or separate the individuals. Also disclosed are methods of determining the survival rate of individuals, growth rate of individuals, and increase in biomass of each of the contributing populations, and the impact of environmental conditions on the survival or growth or increase in biomass of the contributing populations. Also disclosed are methods to study population dynamics in mixed populations of microbes. In addition methods are disclosed to trace chromosomal segments back to founder populations or individuals. | 08-18-2011 |
20110202280 | SYSTEMS AND METHODS FOR ERROR CORRECTION IN DNA SEQUENCING - Disclosed are systems and methods for polynucleotide sequencing where detection and correction of base calling errors can be achieved without reliance on a reference sequence. In certain embodiments, redundant information can be introduced during measurement so as to allow such detection of errors. Such redundant information and measurements can be facilitated by encoding of nucleotide sequence being measured. Various examples of such encoding, redundancy introduction, and decoding are provided. | 08-18-2011 |
20110202281 | ADAPTIVE BIOCHEMICAL SIGNATURES - The present invention is related to methods of generating adaptive biochemical signatures in live cells and the use of said signatures to identify diagnostic and therapeutic modalities for human disease. The methods described herein comprise contacting a provocative agent to live cells and measuring and analyzing adaptive readouts. The methods of the invention may be used for therapeutic or diagnostic purposes. | 08-18-2011 |
20110202282 | Multi-Stage Search for Microbe Mass Spectra in Reference Libraries - Microbes in a sample are identified by calculating similarities between a mass spectrum of the sample and reference mass spectra in a spectral library. The spectral library is divided into a hierarchy of sub-libraries where each sub-library contains reference mass spectra of microbes which are statistically the most prevalent in the samples, but are not included in other sub-libraries and all additional reference mass spectra in the library that have substantial similarity to the reference mass spectra of these microbes. Only if the search in a sub-library does not provide a hit with sufficient certainty of identification, is the search carried out in sub-libraries of higher stages. | 08-18-2011 |
20110202283 | SYSTEMS AND METHODS FOR FAULT DIAGNOSIS IN MOLECULAR NETWORKS - The present disclosure provides advantageous systems and methods for identifying molecular vulnerabilities in biological pathways and networks. The present disclosure generally involves conceptualizing a disease/disorder at the molecular level as a faulty physiological system, wherein one or more molecules in the complex intracellular signaling network are dysfunctional. This is accomplished by modeling a given physiological system as a digital logic circuit. More particularly, in exemplarily embodiments, binary logic equations are derived by analyzing the interactions between the input and output nodes of a target biological system. These equations are then used to produce a digital circuit representation for the system. Once a digital circuit representation is created, this circuit may advantageously be analyzed, using fault analysis techniques, in order to determine the vulnerability levels of the molecules of the targeted system. | 08-18-2011 |
20110202284 | NOVEL GROUPS OF BIOMARKERS FOR DIAGNOSING ALZHEIMER'S DISEASE - The inventors have discovered sets of proteinaceous biomarkers which can be measured in biological fluid samples to diagnosis or aid in the diagnosis of Alzheimer's disease and distinguish AD samples from non-demented samples. | 08-18-2011 |
20110202285 | NMR METHOD FOR DIFFERENTIATING COMPLEX MIXTURES - A method for differentiating complex mixtures each having one or more chemical species is provided. The method comprises producing a sample NMR spectrum by subjecting a mixture to a selective spectroscopy process, wherein the NMR spectrum has individual spectral peaks representative of the one or more chemical species within the mixture. The one or more chemical species within the mixture are identified by analyzing the individual spectral peaks, and the individual spectral peaks are then subjected to a multivariate statistical analysis. | 08-18-2011 |
20110202286 | Optical System Determination According to Advanced Criteria - A method implemented by computer means for calculating by optimization an optical system for example an ophthalmic lens according to at least one criterion among the following list consisting of: ocular deviation, object visual angular field in central vision, image visual angular field in central vision, pupil field ray deviation, object visual angular field in peripheral vision, image visual angular field in peripheral vision, prismatic deviation in peripheral vision, magnification in peripheral vision, lens volume, magnification of the eyes, temple shift, or a variation of preceding criteria. | 08-18-2011 |
20110208432 | SYSTEMS AND METHODS FOR PRESUMPTIVE IDENTIFICATION OF MICROORGANISM TYPE IN A CULTURE - Systems, methods and apparatus for identifying a microorganism type in a culture are provided. A normalization relative value is calculated for each respective measurement of a biological state of the culture between (i) the respective measurement and (ii) an initial biological state. For each fixed interval of time points, a first derivative of the normalization relative values in the interval of time points is calculated, thereby forming a plurality of rate transformation values. For each respective set of rate transformation values in the plurality of rate transformation values, a measure of central tendency of the rate transformation values in the set is computed, thereby forming a plurality of average relative transformation values. A maximum metabolic rate and an extent of growth, determined from the normalization relative values and the average relative transformation values, are compared against a lookup table that matches these values to a microorganism type. | 08-25-2011 |
20110208433 | Cancer patient selection for administration of therapeutic agents using mass spectral analysis of blood-based samples - Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a solid epithelial tumor cancer patient is likely to benefit from a therapeutic agent or a combination of therapeutic agents targeting agonists of the receptors, receptors or proteins involved in MAPK (mitogen-activated protein kinase) pathways or the PKC (protein kinase C) pathway upstream from or at Akt or ERK/JNK/p38 or PKC, such as therapeutic agents targeting EGFR and/or HER2. The methods also provide the ability to determine whether the cancer patient is likely to benefit from the combination of a therapeutic agent targeting EFGR and a therapeutic agent targeting COX2; or whether the cancer patient is likely to benefit from the treatment with an NF-κB inhibitor. | 08-25-2011 |
20110208434 | METHOD AND SOFTWARE FOR CARDIOVASCULAR ASSESSMENT AND RISK DETECTION - The present invention provides an improved comprehensive method of assessing an individual's risk of developing CVD through analysis of multiple factors know to be associated with the development of cardiovascular disease. The factors include the classic Framingham factors of an individual's age, blood pressure, total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, history of diabetes and history of cigarette smoking, in addition to factors know to be associated with increased risk of CVD including inflammation, insulin resistance, obesity, kidney dysfunction. | 08-25-2011 |
20110208435 | CAPACITANCE DETECTION IN ELECTROCHEMICAL ASSAYS - A method and system are provided to determine fill sufficiency of a biosensor test chamber by determining capacitance of the test chamber. | 08-25-2011 |
20110208436 | METHOD OF PERFORMING A SERIES OF EXPERIMENTS, AN INTEGRATED CONTINUOUS PHARMACEUTICAL PRODUCT PROCESSING SYSTEM, AND A COMPUTER PROGRAM PRODUCT - In the method, a series of experiments is performed in order to explore a set of process parameter ranges and/or a set of ingredient ranges of a pharmaceutical processing system. The method comprises step | 08-25-2011 |
20110208437 | METHOD AND APPARATUS FOR IDENTIFYING A SAFE AND EFFICACIOUS DOSING REGIMEN - The invention features methods and systems to provide, in one test session, information on the patient's sensitivity to a probe drug for treating attentional disorders. The methods and systems of the invention can enable clinicians and consumers to ascertain how much benefit an individual would derive from treatment, what dose would be required, and the acute effect of that dose on regularity and rhythmicity of their heartbeat. | 08-25-2011 |
20110208438 | SYSTEM FOR AUTOMATICALLY TESTING A FLUID SPECIMEN - A system for automatically testing a fluid specimen, e.g., urine, to indicate the presence of specified chemical components in the specimen. The system preferably utilizes an assaying device comprised of a collection cup and a cap which carries at least one test strip. The device includes an integrated aliquot delivery mechanism actuatable to wet the test strip with an aliquot delivered from the fluid specimen. The assaying device is configured to operate in conjunction with an electronic reader device capable of actuating the aliquot delivery mechanism and reading the reaction of the test strip. A preferred reader device defines a keyed receptacle for accommodating a complementary shaped cup housing in a particular orientation. The reader device is comprised of a camera for capturing the image of a test strip, an actuator for actuating an aliquot delivery mechanism, and a microprocessor/controller for (1) controlling the camera and actuator and (2) processing the image. | 08-25-2011 |
20110208439 | METHODS FOR MEASURING THE MAGNITUDE OF ATTENTION AND MOTOR ACTIVITY DISTURBANCE IN A SUBJECT - The invention features methods and systems to monitor changes in the magnitude of attentional disturbance and the magnitude of motor activity disturbance in a subject. The invention also features methods and systems for determining a subject's degree of concordance with individuals having an attentional disorder versus individuals not having an attentional disorder. The methods and systems of the invention can enable clinicians and consumers to ascertain both the severity of an attentional disorder as well as how much an individual changes over time, or with therapy. | 08-25-2011 |
20110213557 | Assessing the effectiveness of psychiatric medication in physicians' practices - Disclosed is a method of efficiently assessing the effectiveness of psychiatric medications as administered by physicians and more specifically to a methodology that compares the effectiveness of different medications across groups of patients based on changes in mental health scores using electronic systems. Additionally, the invention delineates when changes in medications are made during the course of medical visits for a single patient. | 09-01-2011 |
20110213558 | METHOD FOR PREDICTING ACTIVATION ENERGY USING AN ATOMIC FINGERPRINT DESCRIPTOR OR AN ATOMIC DESCRIPTOR - The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors. Specifically, the invention provides a method of predicting the activation energy either for cytochrome P450-mediated hydrogen abstraction or for tetrahedral intermediate formation in cytochrome P450-aromatic hydroxylation using equations including effective atomic descriptors. The method of the invention can rapidly predict activation energy for phase I metabolites at a practical level without having to perform a docking experiment between any additional CYP450 and the substrate, or a quantum mechanical calculation, thereby making it easier to develop new drugs using a computer. Also, the present invention may propose a strategy for increasing the bioavailability of drugs through the avoidance of metabolites based on the possibility of drug metabolism. Furthermore, the method of the present invention proposes new empirical approaches which can also be easily applied to activation energies for various chemical reactions, and makes it possible to explain physical and chemical factors that determine activation energy. In addition, through the prediction of activation energy according to the present invention, it is possible to predict i) metabolic products, ii) the relative rate of metabolism, iii) metabolic regioselectivity, iv) metabolic inhibition, v) drug-drug interactions, and vi) the toxicity of a metabolite. | 09-01-2011 |
20110213559 | MULTI-SENSOR PATCH AND SYSTEM - Embodiments of the invention provide systems and methods for remote sensing and/or monitoring utilizing a sensing device, such as may be implemented in a patch that can be placed on or affixed to a subject, where the sensing device includes multiple sensors. For example, one embodiment of the present invention includes a wireless human temperature skin patch providing accurate measurement of human temperature from a sensing device applied to the skin and even in the presence of differing ambient temperature. In such an embodiment, the patch can include, for example, a flexible, breathable bandage or adhesive strip or pad to affix the sensing device to a patient. The sensing device can include multiple sensors such as two or more temperature sensors that can be used to accurately determine the patient's core body temperature from the measured temperature at the skin. | 09-01-2011 |
20110213560 | System, method, and computer product for exon array analysis - In one embodiment, a method for analyzing data generated by probe arrays is described that comprises receiving user selections of two or more data files and an identification of one or more subsets of intensity values acquired from a biological probe array. The method includes iteratively opening each data file, identifying the selected subset of intensity values associated with each open data file, determining parameters for processing, storing the parameters and the identified intensity values, and closing the open data file prior to the subsequent iteration. The method then includes processing the stored intensity values using the parameters to identify one or more biological events. | 09-01-2011 |
20110213561 | METHOD FOR TESTING PERITONEUM FUNCTION AND A PERITONEAL DIALYSIS PLANNING APPARATUS - The present invention is a peritoneal function testing method characterized by using a ratio MTAC | 09-01-2011 |
20110213562 | FLUORESCENT AGENT CONCENTRATION MEASURING APPARATUS, DOSE CONTROL APPARATUS, ADMINISTRATION SYSTEM, FLUORESCENT AGENT CONCENTRATION MEASURING METHOD, AND DOSE CONTROL METHOD - A fluorescent agent accumulation concentration measuring apparatus is configured to include a single-wavelength LED to radiate excitation light to a test bottle loaded in the inside, a barrier filter to transmit only fluorescence from the test bottle, a photoreceptor to receive the fluorescence through the barrier filter and output an electric signal, a detection processing circuit to conduct signal processing of the electric signal from the photoreceptor and detect the fluorescence intensity, and an operation circuit | 09-01-2011 |
20110218738 | CHARACTERIZATION OF MOLECULES - The invention involves obtaining signatures of species (including chemical, biological, or biochemical molecules) and/or signatures of interactions between species and using them to characterize species, characterize interactions, and/or identify species that could be useful in a variety of settings. Signatures can be obtained using aqueous multi-phase partitioning and can be used to predict molecular interactions for applications such as drug discovery. A plurality of aqueous multi-phase partitioning arrangements can define an overall system providing an information-intensive signature, maximizing precision and sensitivity. | 09-08-2011 |
20110224908 | Gene signature for diagnosis and prognosis of breast cancer and ovarian cancer - A first embodiment is a breast cancer prognosticator comprising a detection mechanism consisting a 15-gene signature. In addition there are embodiments comprised of 23-gene signatures and 28-gene signatures. The 28-gene signature may also be used for the prognosis of ovarian cancer. A second embodiment is a method to determine metastatic potential, relapse potential, or both in breast cancer patients comprising collecting a sample from an individual, removing marker-derived polynucleotide from said sample, using a detection mechanism to search for positive matches of said polynucleotides and either the 15, 23, or 28-gene signatures, and developing a quantitative expression profile. Utilizing risk analysis the individual can be placed into one of two or more groups predicting risk and/or clincopathogic variables. Another embodiment is a method to determine relapse free potential in breast cancer patients comprising collecting a sample from an individual, removing marker-derived polynucleotide from said sample, using a detection mechanism to search for positive matches of said polynucleotides and a 24-gene signature, and developing a quantitative expression profile. | 09-15-2011 |
20110224909 | SIGNAL PROCESSING TECHNIQUE FOR AN IMPEDANCE BIOSENSOR - A method for determining impedance includes receiving a time varying voltage signal from a biosensor and receiving a time varying current signal from the biosensor. The time varying voltage signal and the time varying current signal are transformed to a domain that represents complex impedance values. Parameters based upon the impedance values using at least one of an explicit decimation process and an implicit decimation process. | 09-15-2011 |
20110224910 | METHODS OF NORMALIZING MEASURED DRUG CONCENTRATIONS AND TESTING FOR NON-COMPLIANCE WITH A DRUG TREATMENT REGIMEN - Methods for monitoring subject compliance with a prescribed treatment regimen are disclosed. In one embodiment, the method comprises measuring a drug level in fluid of a subject and normalizing said measured drug level as a function of one or more parameters associated with the subject. The normalized drug level is compared to a reference value and associated confidence intervals or to a concentration range. The reference value and associated confidence intervals and/or the concentration range may be normalized based on one or more parameters associated with subjects in a reference population. | 09-15-2011 |
20110224911 | METHODS AND MATERIALS FOR CANINE BREED IDENTIFICATION - In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations. | 09-15-2011 |
20110224912 | Physiological Monitor System for Determining Medication Delivery and Outcome - A method is described for the determination of the taking of a medication utilizing at least one physiological parameter monitoring platform. In addition, the method also may enable the determination of physiological effects or events resultant from the taking of a medication (or lack thereof) through the use of one or more physiological monitoring platforms. | 09-15-2011 |
20110224913 | METHODS AND SYSTEMS FOR PREDICTING PROTEINS THAT CAN BE SECRETED INTO BODILY FLUIDS - The present invention is directed to methods and systems for predicting protein secretion into bodily fluids. In an embodiment, a method uses a feature set comprising secretory properties of collected proteins to train a classifier, based on the feature set, to recognize protein features corresponding to proteins that are likely to be secreted into a biological fluid. Another method determines, using a trained classifier and identified features of a received protein sequence, the probability of the protein sequence being secreted into a biological fluid. In an embodiment, a system predicts the secretion of proteins into a biological fluid. The system comprises components configured to construct a protein feature set comprising properties of collected proteins, train a classifier to predict features of a protein that is likely to be secreted into the biological fluid, receive a protein sequence, and identify the received protein sequence as a secretory protein. | 09-15-2011 |
20110224914 | CONSTRAINED PROCESSING TECHNIQUE FOR AN IMPEDANCE BIOSENSOR - A system for determining impedance includes receiving a time varying voltage signal from a biosensor and receiving a time varying current signal from the biosensor. The time varying voltage signal and the time varying current signal are transformed to a domain that represents complex impedance values. Parameters based upon the impedance values are calculated using at least one constrained pole set to a DC value. | 09-15-2011 |
20110224915 | METHOD AND APPARATUS FOR A SELF-POWERED RFID-READABLE PEDOMETER - A device, system and method for analyzing a user's motion using a piezoelectric film to generate a plurality of deformation signals based upon an associated plurality of deformations, an EEPROM to record data associated with the plurality of deformation signals, and a transceiver to receive at least a portion of the recorded data from the EEPROM and to transmit data, wherein the analysis may determine an abnormality in the user's gait. | 09-15-2011 |
20110231101 | BODY MOVEMENT ANALYSIS METHOD AND APPARATUS - A method and apparatus is disclosed for calculating a mobility performance index of a patient. The method includes the steps of: measuring an activity signal; identifying an activity type by segmenting said activity signal; calculating a measure for a selected said identified activity type; and calculating a mobility performance index from said measure. | 09-22-2011 |
20110231102 | METHOD, SYSTEM AND SOFTWARE ARRANGEMENT FOR COMPARATIVE ANALYSIS AND PHYLOGENY WITH WHOLE-GENOME OPTICAL MAPS - The present invention provides a method for organizing genomic information from multiple organisms. In one embodiment of the invention, phylogenetic trees can be constructed for the organisms. The method of the present invention is termed CAPO, Comparative Analysis and Phylogeny with Optical-Maps. Optical maps of organisms are obtained and phylogeny between the organisms is determined by optical map comparison and bipartite graph matching between the organisms, as, for example, computed by a stable marriage algorithm. | 09-22-2011 |
20110231103 | METHODS FOR DETERMINING MOLECULAR PHARMACOLOGY USING LABEL-FREE INTEGRATIVE PHARMACOLOGY - Disclosed are methods and machines to perform cluster analysis on label free biosensor data. | 09-22-2011 |
20110231104 | SYSTEM AND METHOD FOR TARGETING RELEVANT RESEARCH ACTIVITY IN RESPONSE TO ANGIOGENIC REGULATOR ANALYSES - A system and method for targeting relevant research activity for clinical application in response to angiogenic regulator analyses. An angiogenic analysis is performed on a patient blood sample in order to detect the level of each of at least ten angiogenic regulators. The levels of the tested regulators are used as indexes to identify relevant peer-reviewed research publications from among a large database of articles. The most relevant peer-reviewed literature reporting research and studies that have been conducted to identify, moderate, and define the mechanisms unique to individual and combinations of angiogenic regulators for various disease states are then provided to the patient and/or to the patient's physician, optionally in conjunction with a summarization of the treatment recommendations gleaned from the provided literature. The customized information delivery provides the patient and physician a range of published peer-reviewed therapeutic options and published research studies for moderating the out of range regulators to within normal range or other diagnostic significant range. | 09-22-2011 |
20110231105 | Residual Compensation Including Underfill Error - A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system compensates at least 50% of the total error in the output signal with a primary function and compensates a portion of the remaining error with a residual function. The amount of error compensation provided by the primary and residual functions may be adjusted with a weighing coefficient. The compensation method including a primary function and a residual function may be used to determine analyte concentrations having improved accuracy from output signals including components attributable to error. | 09-22-2011 |
20110231106 | STATUS DETERMINATION - The present invention provides a method of determining the status of a subject. In particular, this is achieved by obtaining subject data including respective values for each of a number of parameters, the parameter values being indicative of the current biological status of the subject. The subject data is compared to predetermined data which includes values for at least some of the parameters and an indication of the condition. The status of the subject, and in particular, the presence and/or absence of the one or more conditions, can then be determined in accordance with the results of the comparison. | 09-22-2011 |
20110231107 | TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. | 09-22-2011 |
20110231108 | PROTEIN STRUCTURE ANALYSIS - Techniques for analyzing one or more protein structures. In one aspect of the invention, the technique comprises the following steps. A normalized second-order hydrophobic moment is determined for a protein structure. The normalized second-order hydrophobic moment is then used for analysis of the protein structure. A scoring function in accordance with the normalized second-order hydrophobic moment for the protein structure may be determined. A score for the protein structure may then be generated using the scoring function. The scoring function may represent an integral of the normalized second-order hydrophobic moment. The scores may be generated for a plurality of protein structures. The scores generated for the plurality of protein structures may then be compared. | 09-22-2011 |
20110238316 | SECONDARY STRUCTURE DEFINING DATABASE AND METHODS FOR DETERMINING IDENTITY AND GEOGRAPHIC ORIGIN OF AN UNKNOWN BIOAGENT THEREBY - The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity. | 09-29-2011 |
20110238317 | System for forecasting outcomes of clinical trials - A system for forecasting outcomes of clinical trials including a digital computer having a central processor, a programmable graphical or programmable analog coprocessor in communication with the central processor, interface software in communication with the central processor and coprocessor, modeling software having simulation capability substantially executed by the central processor and in communication with the interface software, integration software substantially executed by the central processor in communication with the modeling software, partial derivative software substantially executed by the coprocessor and in communication with the interface software, a historical clinical trial data component, a model data component specifying the time course of a clinical observation by a differential equation, and a protocol data component specifying the characteristics of a population intended to undergo a future clinical trial, all the said data components in communication with the modeling software. | 09-29-2011 |
20110238318 | Simple algorithm for quantifying polymorphisms in electropherograms - A method for quantifying cytosine methylation at a particular target CpG site in DNA of a cell or organism, by performing bisulfite genomic sequencing, wherein a DNA sample extracted from a cell or organism is treated with sodium bisulfite to convert cytosine to uracil and a selected fragment of this treated DNA is amplified, performing a sequence analysis of the amplificate from an electropherogram wherein the area under a peak is measured in a plurality of peaks at either side of the target CpG site to determine the mean T area (T bar) surrounding the site, subtracting the area of the T at the target CpG site from the mean T area wherein the difference is termed delta T, and calculating the proportional level of methylation as a quotient of delta T/T bar, or as a percent value, is presented. | 09-29-2011 |
20110238319 | METHOD OF DIAGNOSING A RESPIRATORY DISEASE - There is provided, a method of diagnosing a disease state in a subject comprising: (a) obtaining nuclear magnetic resonance data on an obtained biological sample from the subject; (b) performing a statistical analysis on the nuclear magnetic resonance data; (c) determining a subject profile for the biological sample based on the statistical analysis; (d) comparing the subject profile to a predetermined profile for differentiating between: (i) the disease state and a non-diseased state; (ii) a first disease state and a second disease state, or (iii) the first disease state, the second disease state, and the non-diseased state, to provide a diagnosis of the disease state, wherein the comparing does not comprise identification of components of the biological sample. | 09-29-2011 |
20110238320 | INTERACTION FORCE CHANGE PREDICTION APPARATUS AND INTERACTION FORCE CHANGE PREDICTION METHOD - An interaction force change prediction apparatus includes: a pre-mutation combination data creation unit which creates pre-mutation combination data including a plurality of three-residue combinations, each combination having a pair of amino acid residues and one amino acid residue adjacent to one of the amino acid residues in the pair; a post-mutation combination data creation unit which creates post-mutation combination data including post-mutation three-residue combinations; an interaction score calculation unit which calculates a pre-mutation interaction score for the three-residue combinations included in the pre-mutation combination data and a post-mutation interaction score for the post-mutation three-residue combinations included in the post-mutation combination data, by reference to a three-residue combination table; and a predicted-value calculation unit which calculates a difference between the pre-mutation interaction score and the post-mutation interaction score. | 09-29-2011 |
20110238321 | Methods for Assessing Drug Efficacy and Response of Patient to Therapy - Methods of identifying, monitoring and matching patients with appropriate treatments who are at risk for developing a systemic inflammatory condition using a systemic mediator-associated physiologic test profile are provided. The methods of the present invention increase the likelihood of demonstrating clinical efficacy in clinical trial datasets. | 09-29-2011 |
20110238322 | METHODS OF SIMULATING CHEMOTHERAPY FOR A PATIENT - The present invention provides methods for predicting or modeling a chemotherapy outcome for a given patient The method produces chemoresponse data, and presents the chemoresponse data in a clinically meaningful context such that the data can be meaningfully interpreted and evaluated in a clinical context The method of the invention involves correlating in vitro chemoresponse results for a particular patient with historical treatment outcomes Where a population of historical outcomes are matched to the patient by one or more clinical variables and such outcomes are matched to a potential treatment by the in vitro efficacy of the agent received, a meaningful simulation of the potential treatment for the patient can be constructed Simulations, such as survival curves, for a plurality of potential treatments may be generated and compared to contrast the estimated outcomes for several potential treatments, thereby providing the information desirable to design an individualized treatment regimen. | 09-29-2011 |
20110238323 | SYSTEMS AND METHODS FOR AUTOMATED MELTING CURVE ANALYSIS - An experimental melting curve is modeled as a sum of a true melting curve and background fluorescence. A deviation function may be generated based upon the experimental melting curve data and a model of a background signal. The deviation function may be generated by segmenting a range of the experimental curve into a plurality of windows. Within each window, a fit between the model of the background signal and the experimental melting curve data may be calculated. The deviation function may be formed from the resulting fit parameters. The deviation function may include background signal compensation and, as such, may be used in various melting curve analysis operations, such as data visualization, clustering, genotyping, scanning, negative sample removal, and the like. The deviation function may be used to seed an automated background correction process. A background-corrected melting curve may be further processed to remove an aggregation signal. | 09-29-2011 |
20110238324 | BIOLOGICAL INFORMATION MEASURING DEVICE AND CONTROL METHOD THEREOF - A biological information measuring device including: a finger insertion part ( | 09-29-2011 |
20110238325 | Quantitative, multispectral image analysis of tissue specimens stained with quantum dots - A biological sample such as a tissue section is stained with one or more quantum dots and possibly other fluorophores (total number of fluorophores N). A camera coupled to a microscope generates an image of the specimen at a plurality of different wavelengths within the emission spectral band of the N fluorophores. An analysis module calculates coefficients C | 09-29-2011 |
20110238326 | BIOLOGICAL INFORMATION ACQUIRING SYSTEM AND BIOLOGICAL INFORMATION ACQUIRING METHOD - It is an object of the present invention to provide a biological information acquiring system and a biological information acquiring method capable of enhancing the calculation accuracy to more accurately calculate the exercise effect information, and capable of enhancing the satisfaction level of the user. | 09-29-2011 |
20110246076 | Method and System for Word Sequence Processing - A method and system of conducting named entity recognition. One method comprises selecting one or more examples for human labelling, each example comprising a word sequence containing a named entity and its context; and retraining a model for the named entity recognition based on the labelled examples as training data. | 10-06-2011 |
20110246077 | Methods and Apparatus for Screening for Chromosomal Abnormalities - This invention generally relates to methods, apparatus, and computer program code for antenatal screening for chromosomal abnormalities, in particular Down's Syndrome. A method of determining a likelihood of a fetus carried by a pregnant mother having a chromosomal abnormality, a first biological, parameter being suitable for screening said fetus for said chromosomal abnormality, the method comprising: receiving first data from a first stage of pregnancy of said mother, said first data comprising data representing a first value of said first biological parameter; receiving second data from a second, later stage of said pregnancy, said second data comprising data representing a second value of said first biological parameter; and determining likelihood data from said first and second data, said likelihood data representing the likelihood of said fetus having a chromosomal abnormality. | 10-06-2011 |
20110246078 | MITOCHONDRIA KATP ION CHANNEL AS A DRUG TARGET FOR PREVENTING LIVER DISEASES AND METHODS TO SCREEN MITOCHONDRIA KATP MODULATORS - Disclosed are compositions and methods related to modulation of K | 10-06-2011 |
20110246079 | INDIVIDUAL 5-FLUOROURACILE DOSE OPTIMIZATION IN FOLFOX TREATMENT - The present invention belongs to the field of improved personalized medicine. More precisely, the present invention relates to a method for progressively optimizing the 5-FU dose administered by continuous infusion in patients treated by a FOLFOX regimen or a similar regimen, based on the 5-FU plasmatic concentration measured during the previous 5-FU continuous infusion and on a herein described decision algorithm. The present invention also relates to a method for treating a cancer patient in which the 5-FU dose administered in continuous infusion in each FOLFOX or similar treatment cycle is optimized using the decision algorithm according to the invention. | 10-06-2011 |
20110246080 | GENE CLUSTERING PROGRAM, GENE CLUSTERING METHOD, AND GENE CLUSTER ANALYZING DEVICE - [Object] To provide a gene clustering tool that can perform gene clustering based on the data on gene expression level over time without a priori data forecast but with high precision. | 10-06-2011 |
20110257888 | METHOD OF DETERMINING CHRONIC FATIGUE SYNDROME - The present invention provides a method of determining whether or not a subject is affected with chronic fatigue syndrome (CFS) comprising: measuring, in a biological sample from the subject, an expression level of a transcript of at least one gene respectively from at least two gene groups selected from six specific gene groups; calculating a value representing a deviation of the measured expression level based on an expression level of a transcript of the corresponding gene in a population of healthy subjects; obtaining an average of the value(s) representing a deviation; and determining whether or not the subject is affected with CFS by using the average. | 10-20-2011 |
20110257889 | SEQUENCE ASSEMBLY AND CONSENSUS SEQUENCE DETERMINATION - Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof. In particularly preferred embodiments, nucleic acid sequences generated by such methods are subjected to de novo assembly and/or consensus sequence determination. | 10-20-2011 |
20110257890 | Method for Differentially Quantifying Naturally Processed HLA-Restricted Peptides for Cancer, Autoimmune and Infectious Diseases Immunotherapy Development - The invention relates to a method for quantitatively identifying relevant HLA-bound peptide antigens from primary tissue specimens on a large scale without labeling approaches. This method can not only be used for the development of peptide vaccines, but is also highly valuable for a molecularly defined immunomonitoring and the identification of new antigens for any immunotherapeutic strategy in which HLA-restricted antigenic determinants function as targets, such as a variety of subunit vaccines or adoptive T-cell transfer approaches in cancer, or infectious and autoimmune diseases. | 10-20-2011 |
20110257891 | THERAPY PREDICTION AND OPTIMIZATION FOR RENAL FAILURE BLOOD THERAPY, ESPECIALLY HOME HEMODIALYSIS - A method of predicting serum phosphorus concentrations in a patient during hemodialysis includes measuring serum phosphorus concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a phosphorous mobilization clearance and a pre-dialysis distribution volume of phosphorus for the patient. Serum phosphorus concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated phosphorous mobilization clearance and pre-dialysis distribution volume of phosphorus of the patient. | 10-20-2011 |
20110257892 | METHODS FOR IDENTIFYING SETS OF OLIGONUCLEOTIDES FOR USE IN AN IN VITRO RECOMBINATION PROCEDURE - In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided. | 10-20-2011 |
20110257893 | METHODS FOR CLASSIFYING SAMPLES BASED ON NETWORK MODULARITY - Methods for classifying samples are based on alterations in network modularity. The methods are useful for the diagnosis, prognosis and monitoring of a biological state such as a disease state. In certain embodiments, methods for diagnosing disease or evaluating the prognosis of disease or identification of a disease state are computer-implemented. | 10-20-2011 |
20110257894 | METHOD FOR DECONVOLVING SINGLE-MOLECULE INTENSITY DISTRIBUTIONS FOR QUANTITATIVE BIOLOGICAL MEASUREMENTS - A method for quantifying fluorescent puncta comprising acquiring at least one first intensity distribution comprising fluorescence intensity values from a plurality of first fluorescent puncta; acquiring at least one second intensity distribution comprising fluorescence intensity values from a plurality of second fluorescent puncta, wherein each second fluorescent puncta has a determined number of fluorescent emitters; determining the relationship between the first and second intensity distributions; and fitting the second intensity distribution to the first intensity distribution to provide a count and distribution of the number of fluorescent emitters within the first fluorescent puncta. | 10-20-2011 |
20110257895 | TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. | 10-20-2011 |
20110264374 | Method, Computer Program Product and System for Individual Assessment of Alcohol Sensitivity - Methods/computer methods and systems/computer systems for the evaluation of two idiosyncratic indices of alcohol intoxication: the Alcohol Sensitivity Index (ASI), and the brain-specific Cognitive Alcohol Sensitivity Index (CASI). The two indices are based on the new Metabolic and Cognitive Minimal Models of Alcohol Dynamics, and are derived from specific clinical protocols, accompanied by specific data analysis procedures. The two indices may be derived from specific clinical and cognitive assessment protocols, accompanied by specific data analysis procedures based on the new metabolic and cognitive minimal models of alcohol dynamics. | 10-27-2011 |
20110264375 | COMPUTER-ASSISTED MEANS FOR ASSESSING LIFESTYLE RISK FACTORS - The present invention relates to methods of assessing disease susceptibility associated with dietary and lifestyle risk factors. The invention provides for analysis of alleles at loci of genes associated with lifestyle risk factors, and the disease susceptibility profile of an individual is determined by reference to datasets which further match the risk factor with lifestyle recommendations in order to produce a personalized lifestyle advice plan. | 10-27-2011 |
20110264376 | EVALUATING GENETIC DISORDERS - The present invention relates to genetic analysis and evaluation utilizing copy-number variants or polymorphisms. The methods utilize array comparative genomic hybridization and PCR assays to identify the significance of copy number variations in a subject or subject group. | 10-27-2011 |
20110264377 | METHOD AND SYSTEM FOR ANALYSING DATA SEQUENCES - A sequencing system and method of generating index keys for one or more data sequence based on masked values of reads from a sample data sequence and/or one or more template data sequence. Each index key value may be based upon a concatenated form of each extracted value, although other transformations may be employed. A number of different masks may be applied to the data sequence at a number of locations. At least some of the masks may include indels and/or substitutions. The masks may be manually or computer generated. The data sequence may be one or more reference templates and/or one or more sample sequences, such as DNA or RNA sequences. Sample data may be stored in the one or more index by correlating masked values of reads with index key values and storing an identifier for each read in association with a corresponding index key value. Sample data sequences may be evaluated by comparing sample sequence and template sequences having the same index key value and determining scores for the reads based on the comparison and associating the scores with the reads. Reads may be rejected based upon the comparison. A read may be rejected if there is more than one position at which it has a best score. A read may be rejected if its score falls below a threshold score level. | 10-27-2011 |
20110264378 | Method, System, and Computer Program Product For Tracking of Blood Glucose Variability in Diabetes - An embodiment may be in the field of glycemic analysis and control. More specifically, an embodiment or approach may provide a novel method, system, and computer program for the visual and quantitative tracking of blood glucose variability in diabetes from self-monitoring blood glucose (SMBG) data and/or continuous glucose monitoring (CGM) data. More particularly, an embodiment or aspects thereof may use glucose measurements obtained from self-monitoring data and/or CGM data of an individual or a group of individuals to track and analyze blood glucose variability. | 10-27-2011 |
20110270528 | Method for Random Grouping of Multiple Parameters - A method is provided for randomizing at least two factors among subjects, comprising (a) measuring said at least two factors in said subjects; (b) creating candidate solutions comprising said subjects; (c) evaluating fitness of said candidate solution; (d) forming a new generation from candidate solutions; and (d) repeating steps (c) and (d) to obtain a candidate solution with optimal fitness. | 11-03-2011 |
20110270529 | SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR MANAGING A RESEARCH SEED LOCATION - The present invention provides a system, method and computer program product for managing a research seed location. In various embodiments, the method of the present invention comprises storing at least one field characteristic layer in a memory, storing at least one the research plot layer in a memory, and merging the research plot layer and the field characteristic layer via a processor. In some embodiments, the research plot plan may be linked to a research plot database. In some embodiments, plant observation data and/or plant harvest data may be collected and may be merged with the research plot plan. In some embodiments, a seed planting device may be controlled to plant seeds according to the research plot plan. | 11-03-2011 |
20110270530 | COMBINED NATRIURETIC PEPTIDE ASSAYS - The present invention relates to methods for the diagnosis and evaluation of BNP-related diseases. In particular, patient test samples are analyzed for the presence and amount of a plurality of natriuretic peptides, and a combined natriuretic peptide result is used as a diagnostic marker. | 11-03-2011 |
20110270531 | SYSTEM FOR SELECTING PLANTS FROM AMONG A POPULATION OF PLANTS - Provided is a system ( | 11-03-2011 |
20110276275 | Systems And Methods For Wavelet Transform Scale-Dependent Multiple-Archetyping - Methods and systems are disclosed for producing a plurality of archetype signals in wavelet space at a plurality of wavelet scales. A signal is transformed using a continuous wavelet transform based at least in part on a wavelet function. A scale dependent archetype transformed signal is computed based at least in part on the transformed signal and based at least in part on a natural periodicity of the wavelet function used to transform the signal. Information may be derived about the signal from the archetype transform signal, and stored in memory. | 11-10-2011 |
20110276276 | APPARATUS AND METHOD FOR DETERMINING ANALYTE CONCENTRATIONS - An apparatus and method for determining an analyte concentration of a sample, such as a tissue sample. The apparatus may comprise an emitter, close proximity detectors laterally located less than about 2 mm away from the emitter, and far away detectors laterally located greater than about 0.5 cm away from the emitter. A plurality of wavelengths may be sent from the emitter to the sample, reflected off of the sample, and received by the detectors. The reflectance value measured by the close proximity detectors may be used to calculate one or more scattering coefficients. The reflectance value measured by the far away detectors may be compared with a reflectance value calculated using the scattering coefficients in a numerical inversion of a diffusion model to determine the analyte concentration of the sample. | 11-10-2011 |
20110282585 | HEPATIC DISEASE-EVALUATING APPARATUS, HEPATIC DISEASE-EVALUATING METHOD, HEPATIC DISEASE-EVALUATING SYSTEM, HEPATIC DISEASE-EVALUATING PROGRAM AND RECORDING MEDIUM - In a hepatic disease-evaluating apparatus, an indicator calculating unit calculates an index indicating the degree of hepatic fibrosis from amino acid concentration data to be evaluated including amino acid concentration value, based on one or more indices of fractional expression having amino acid concentration as variable. A disease state evaluating unit evaluates the disease state of the hepatic disease to be evaluated, based on the index value. | 11-17-2011 |
20110282586 | SYSTEMS AND METHODS TO DETERMINE OPTIMAL DIAMETERS OF VESSEL SEGMENTS IN BIFURCATION - Systems and methods to determine optimal diameters of vessel segments in bifurcation. In at least one embodiment of a method for determining a diameter of a segment of a bifurcated vessel of the present disclosure, the method comprises the steps of identifying a diameter of a first segment of a bifurcated vessel, identifying a diameter of a second segment of the bifurcated vessel, and determining a diameter of a third segment of the bifurcated vessel based upon the diameter of the first segment and the diameter of the second segment, wherein the determination is further based upon an exponential relationship of or about 7/3 for each diameter. | 11-17-2011 |
20110282587 | COMPUTER READABLE STORAGE MEDIUMS, METHODS AND SYSTEMS FOR NORMALIZING CHEMICAL PROFILES IN BIOLOGICAL OR MEDICAL SAMPLES DETECTED BY MASS SPECTROMETRY - Described herein are computer-readable storage mediums, methods and systems useful for analyzing samples via mass spectrometry. Aspects described herein include methods for normalizing mass spectrometry data that include providing a reference set of mass spectrometry data obtained from a first external standard sample having one or more isotopic standards, wherein the reference set of mass spectrometry data comprises one or more m/z intensity ratios. Methods described herein are useful for reducing errors based on instrument response and ionization efficiencies and improve reproducibility of data from instrument to instrument and from day to day. | 11-17-2011 |
20110282588 | Method to automatically identify peaks and monoisotopic peaks in mass spectral data for biomolecular applications - A method for automatically identifying peaks in mass spectral data includes estimating m/z-dependent levels of background and noise, detecting all peaks with signal-to-noise ratio above a user-specified threshold, and compiling a list of all detected peaks including their m/z positions and intensities. The method can be extended to automatically detect monoisotopic peaks, to detect monoisotopic peaks in the presence of chemical noise, and to detect resolved isotopic clusters at high mass. | 11-17-2011 |
20110288779 | SYSTEM AND METHOD OF DATA-DEPENDENT ACQUISITION BY MASS SPECTROMETRY - Systems, computer-readable media, and methods using mass spectrometry to analyze a sample are provided. For example, a method includes: acquiring a precursor ion spectrum; analyzing the precursor ion spectrum to identify precursor ions that preliminarily match one or more peptides that each belong to at least one protein of interest for the analysis; selecting each of the identified precursor ions in an order according to a ranking protocol for maximizing the number of proteins that are identified in the sample; for each selected precursor ion: acquiring a corresponding product ion spectrum, determining whether the acquired product ion spectrum matches one of the peptides that belong to the set of proteins of interest, and identifying a matched peptide as being present in the sample; and identifying proteins of interest that are present in the sample based on the peptides that are identified as being present in the sample. | 11-24-2011 |
20110288780 | Methods for Non-Invasive Prenatal Ploidy Calling - Methods for non-invasive prenatal ploidy calling are disclosed herein. Methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of DNA from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father are disclosed herein. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias. | 11-24-2011 |
20110288781 | SYSTEMS AND METHODS FOR CHARACTERIZING A BIOLOGICAL CONDITION OR AGENT USING SELECTED GENE EXPRESSION PROFILES - Methods are provided for evaluating a biological condition of a subject using a calibrated profile data set derived from a data set having a plurality of members, each member being a quantitative measure of the amount of a subject's RNA or protein as distinct constituents in a panel of constituents. The biological condition may be a naturally occurring physiological state or may be responsive to treatment of the subject with one or more agents. Calibrated profile data sets may be used as a descriptive record for an agent. | 11-24-2011 |
20110288782 | SYSTEM FOR DETERMINING STATE AND ACTION OF HUMAN BODY AND METHOD OF DETERMINING STATE OF HUMAN BODY, USING AN OPTICAL SIGNAL - Disclosed herein is a system for determining the state and action of the human body using an optical signal. The system includes an optical signal transmission module configured to generate and output the optical signal, an optical signal transfer module configured to include at least one optical signal transfer path that is wearable on a region of the human body and that has at least one cut portion, and a human body state analysis module configured to determine a variation in the state of the human body by calculating the light transmission ratio of the at least one optical signal transfer path which varies depending on the gap of the at least one cut portion of the at least one optical signal transfer path. The gap varies depending on a variation in a circumference of the region of the human body. | 11-24-2011 |
20110288783 | SYSTEM FOR PREDICTING DRUG EFFECTS AND ADVERSE EFFECTS AND PROGRAM FOR THE SAME - A drug effect-adverse effect prediction system includes a clinical data analysis table generating part, for each combination of genotypes relating to a drug effect or adverse effect, for generation of an analysis table for handling cases related to presence or absence of the drug effect or adverse effect. The system also includes a reliability analysis part, a discrimination formula generating part, a prediction part, and a discrimination formula optimizing part. | 11-24-2011 |
20110288784 | Monitoring Energy Expended by an Individual - Methods, apparatuses and systems of monitoring energy expended by an individual are disclosed. One method includes sensing, by a motion sensor, motion of the individual, identifying a plurality of activities performed by the individual over a period of time based on the identified motions, estimating, by a processor, energy expended by the individual for each of the plurality of the plurality of identified activities, and estimating energy expended by the individual by summing the estimated energy expended for each of the plurality of activities. | 11-24-2011 |
20110295511 | APPARATUS AND METHOD FOR DETECTING THE PRESENCE OF AN AGENT - An apparatus and method for detecting an agent utilizes a substrate, a waveguide on the substrate, a light source, a photo-detector, an optical coupler on the substrate, and a processor. The light source is configured to emit light into the waveguide. The photo-detector is configured to detect light. The optical coupler is configured to direct a first portion of light propagating from the waveguide towards the photo-detector and to direct a second portion of the light propagating from the waveguide back into the waveguide. The waveguide and the optical coupler at least partially form a resonator. A substance is at least one of embedded within the waveguide and adjacent to the waveguide. The substance is reactive to the agent. The processor detects a change in a resonance lineshape of the resonator caused by the reaction of the substance to the agent. | 12-01-2011 |
20110295512 | GRADIENT INJECTION FOR BIOSENSING - A single injection gradient with a biosensor, both structural and methodological, achieves the binding of analyte to immobilized ligand over a wide concentration range without the necessity of regeneration of the sensing area. A gradient of concentrations adjacent to or within a flow cell facilitates kinetic analysis of interactions without requiring multiple discrete volumes or injections to achieve a range of concentrations. A continuous gradient fluid is preferably formed directly adjacent to the flow cell inlet or a region of sample/buffer dispersion at an injection point into a flow channel of a flow cell. The analyte gradient may be flowed through the flow cell from a low analyte concentration. Multiple component gradients are also provided. | 12-01-2011 |
20110295513 | INFORMATION PROCESSING APPARATUS, INFORMATION OUTPUT METHOD, AND PROGRAM - There is provided an information processing apparatus including a data acquisition section which acquires input data for recognizing a growth status of a living thing, a recognition section which recognizes a growth status of the living thing based on the input data acquired by the data acquisition section, an agent control section which determines a state of an agent associated with the living thing depending on the growth status of the living thing recognized by the recognition section, and an output section which outputs an agent image corresponding to the state of the agent determined by the agent control section. | 12-01-2011 |
20110295514 | Computational Methods For Translating A Sequence Of Multi-Base Color Calls To A Sequence Of Bases - Disclosed are systems and methods for resequencing using color calls. A DNA sample is encoded and sequenced according to a multi-base code producing a string of read color calls for a fragment of the sample. A reference sequence is obtained. The string of read color calls is mapped to the reference sequence. A base sequence is extracted from the reference sequence. The base sequence is encoded as a string of reference color codes according to the multi-base code. The string of read color calls is aligned with the string of reference color codes and mismatches in the alignment are detected. One or more mismatches of the string of read color calls are annotated as inconsistent. The one or more inconsistent mismatches of the string of read color calls are corrected. The string of corrected read color calls is decoded to bases producing a read sequence. | 12-01-2011 |
20110295515 | METHODS AND SYSTEMS FOR FAST AUTOMATIC BRAIN MATCHING VIA SPECTRAL CORRESPONDENCE - Methods and systems determine a correspondence of two sets of data, each data set represents an object. A weighted graph is created from each data set, and a Laplacian is determined for each weighted graph, from which spectral components are determined. The spectral components determine a coordinate of a node in a weighted graph. Nodes of a weighted graph are weighted with a quantified feature related to anode. A coordinate related to a quantified feature of a node is added to the coordinate based on the spectral components. Spectral components related to a weighted graph are reordered to a common ordering. Reordered spectral components related to the first and second data set are aligned and a correspondence is determined. An object may be a brain and a feature may be a sulcal depth. Other objects for which a correspondence may be determined include an electrical network, an image and a social network. | 12-01-2011 |
20110295516 | BIOINFORMATIC APPROACH TO DISEASE DIAGNOSIS - A kit and test panel utilizing a multivariate diagnostic method based on optimizing diagnostic likelihood ratios through the effective use of multiple diagnostic tests is disclosed. The Neyman-Pearson Lemma provides a mathematical basis to produce optimal diagnostic results. The method can comprise identifying those tests optimal for inclusion in a diagnostic panel, weighting the result of each component test based on a multivariate algorithm described below, adjusting the algorithm's performance to satisfy predetermined specificity criteria, generating a likelihood ratio for a given patient's test results through said algorithm, providing a clinical algorithm that estimates the pretest probability of disease based on individual clinical signs and symptoms, combining the likelihood ratio and pretest probability of disease through Bayes' Theorem to generate a posttest probability of disease, interpreting that result as either positive or negative for disease based on a cutoff value, and treating a patient for disease if the posttest probability exceeds the cutoff value. | 12-01-2011 |
20110295517 | NMR ANALYZERS FOR CLINICAL EVALUATION OF BIOSAMPLES - The clinical analyzers automatically electronically monitor selected parameters and automatically electronically adjust parameters to maintain the analyzer within desired operational ranges. The clinical NMR analyzers can be configured as a networked system with a plurality of clinical NMR analyzers located at different use sites. | 12-01-2011 |
20110295518 | METHODS OF ASSOCIATING AN UNKNOWN BIOLOGICAL SPECIMEN WITH A FAMILY - The present invention provides at least three methods of predicting whether an unknown biological specimen originates from a member of a particular family. These methods compare DNA profiles from unknown biological specimens to DNA profiles of more than one family member, which significantly increases the methods' identification ability. In particular, the invention describes combining at least a ranked first family member list and a ranked second family member list to create a combined ranked list and identifying the unknown biological specimen as one contained among a list of specimens having the highest combined rankings representing the candidates that are most likely related to the family. A second method encompasses comparing test DNA profiles from unknown biological specimens to a family pedigree comprising target DNA profiles obtained from multiple biological specimens of family members. This method also embodies using a modified Elston Stewart algorithm to determine a pedigree likelihood ratio to rank and identify the test profile of the unknown biological specimen most likely to be the missing person sought after by the corresponding family represented by the family pedigree. A third method encompasses construction of a database or directed graph of discovered or known relationships between biological specimens and comparison to a graph representing a family pedigree to identify portions of the database or directed graph that correspond to portions of the family pedigree, in order to rank or identify one or more unknown biological specimens as most likely related to one or more family pedigrees. | 12-01-2011 |
20110301852 | Systems And Methods For Estimating Stability Of A Continuous Wavelet Transform - Methods and systems are disclosed for analyzing a physiological signal obtained from a patient. The physiological signal is transformed using a continuous wavelet transform to generate a transformed signal, and a scalogram is generated from the transformed signal. A region of relative high energy in the scalogram is identified, and dimension information regarding the region is determined. The dimension information is processed to determine physiological information about the patient and confidence information regarding the signal. A storage device coupled to the electronic processing equipment may be used to store the physiological and confidence information. | 12-08-2011 |
20110301853 | Tumor Discriminator - A tumor discriminator determines if a biological sample is diseaseous. Summarized expression value samples in a reference dataset are determined. The summarized expression value being a summation of gene expression levels for disease and normal samples. A biological sample summarized expression value is determined using a gene expression profile for a biological sample. A disease sample distance is estimated from the biological sample summarized expression value to a location in the disease sample space. The disease sample space defined by a statistical analysis of the disease samples. A normal sample distance is estimate from the biological sample summarized expression value to a location in the normal sample space The normal sample space defined by a statistical analysis of the normal samples. The disease sample distance is compared with the normal sample distance to determine if the biological sample is diseaseous. | 12-08-2011 |
20110301854 | Method of Determining Allele-Specific Copy Number of a SNP - A method of estimating the allele-specific copy number of a SNP in a test genome is provided. In certain embodiments, the method involves: a) calculating a plurality of probability distribution functions that fit a plurality of log ratios indicating which alleles of a plurality of single nucleotide polymorphisms (SNPs) are present in diploid regions of a test and reference genome; and b) estimating the allele-specific copy number of a SNP of the test genome using said plurality of probability distribution functions. | 12-08-2011 |
20110301855 | METHOD OF PROCESSING DATA USING AN ALGORITHM FOR LINEAR EXTENSION OF THRESHOLD IN QUANTITATIVE REAL-TIME PCR DATA - Methods that improve the accuracy of gene expression profiling are provided, and more particularly, methods for quantitative PCT (qPCR) used to determine the level of gene expression or gene copy number in a high-throughput fashion. | 12-08-2011 |
20110301856 | METHODS AND SYSTEMS FOR DRUG SCREENING AND COMPUTATIONAL MODELING BASED ON BIOLOGICALLY REALISTIC NEURONS - A method for screening a test composition for potential efficacy in treatment of a disorder includes a first computer model representative of a volume of disease-afflicted neural tissue comprising biologically realistic neurons exposed to the test composition; and providing an initial excitation to the first computer model. Following a selected computation interval, a first outcome is determined. The first outcome indicates a response of the first computer model to the initial excitation and indicates whether the test composition has the potential to be effective in treating the disorder. | 12-08-2011 |
20110301857 | Slope-Based Compensation Including Secondary Output Signals - A biosensor system determines analyte concentration from analytic and/or secondary output signals. The biosensor system adjusts a correlation for determining analyte concentrations from output signals with one or more index functions extracted from the output signals. The index functions determine at least one slope deviation or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias. | 12-08-2011 |
20110301858 | SYSTEMS AND METHODS FOR COMPUTER ASSISTED ALIGNMENT OF CONFORMERS - A computer-assisted method for determining the optimal conformers of biologically active molecules binding any particular receptor. Starting from a set of molecules of known activity at the receptor a conformer library may be generated using any method known to the art including commercially available software. Pair-wise comparison of conformers create alignments and similarity scoring of the alignments. The set of pair-wise alignments is used by the present invention to determine optimal bioactive conformations and to align these conformations in 3-D space for determining the binding mode of the active compounds The invention includes a computer program implementation of such a method. | 12-08-2011 |
20110301859 | PERSONALIZED MOLECULAR MEDICINE - A computer based system and methods for generating and outputting information relating to personalized therapy, including diagnosis and/or treatment is described herein. | 12-08-2011 |
20110301860 | USING DIFFERENTIAL SCANNING CALORIMETRY (DSC) FOR DETECTION OF INFLAMMATORY DISEASE - Disclosed herein in various embodiments are systems and methods for categorizing biological fluids obtained from subjects into one or more disease or treatment categories. Embodiments of the systems and methods may transform easily obtainable body fluids such as blood, plasma, spinal fluid, and other fluids into signature differential scanning calorimetry (DSC) thermograms that may be used to distinguish a positive or negative correlation with a specific inflammatory disease, such as an autoimmune disease. Also disclosed are methods of detecting, diagnosing, and/or monitoring an inflammatory disease in a subject. | 12-08-2011 |
20110301861 | CAPACITANCE DETECTION IN ELECTROCHEMICAL ASSAY WITH IMPROVED SAMPLING TIME OFFSET - A method and system are provided to determine fill sufficiency of an electrochemical biosensor test cell by determining capacitance of the electrochemical test cell. | 12-08-2011 |
20110307180 | SYSTEM AND METHOD FOR ANALYZING METABOLOMIC DATA - The present invention generates a visual display of metabolomic data compiled by a database and associated processor. More particularly, the present invention provides a database for automatically receiving a three-dimensional spectrometry data set for a group of samples. The present invention also provides a processor device for manipulating the data sets to produce plots that are directly comparable to a plurality of characteristic plots corresponding to a plurality of selected metabolites. Furthermore, the processor device may generate a visual display indicating the presence of the selected metabolites across the group of samples. Thus, the present invention enables a user to analyze a series of complex data sets in a visual display that may indicate the presence of the selected metabolites across the group of samples. Furthermore, the visual display generated by embodiments of the present invention also expedites the subjective analysis of the spectrometry data sets. | 12-15-2011 |
20110307181 | ULTRASONIC APPARATUS - An ultrasonic apparatus is provided with an adaptive signal processing block ( | 12-15-2011 |
20110307182 | COMPUTER SYSTEM AND MICROFLUIDIC INSTRUMENTATION FOR NEXT-GENERATION BIOLOGICAL SIGNALING NETWORK RESEARCH AND APPLICATIONS - A computer-controlled micro-instrumentation biochemical reaction environment system includes an electrically-controllable microfludic routing system, at least one microreaction chamber, at least one micro-instrumentation device, and at least one electronic microprocessor. The microreaction chamber supports at least one chemical reaction associated with a biological signaling pathway. The micro-instrumentation device measures at least one physical quantity associated with the signaling pathway. The microprocessor transmits electrical control signals, receives electrical measurement signals, and executes at least one software algorithm. The microreaction chamber is connected to the microfludic routing system to receive and transmit at least a fluid or gas, and the electronic microprocessor receives electrical measurement signals from the micro-instrumentation device via a first electric interface and transmits electrical control signals to electrically-controllable microfludic routing system via a second electrical interface. | 12-15-2011 |
20110307183 | METHOD FOR THE BACTERIOLOGICAL INVESTIGATION OF A BIOLOGICAL SAMPLE AND RELATIVE DEVICE - A method for the bacterial investigation of a biological sample, which provides to carry out a light scattering reading in order to determine the turbidity according to the McFarland standard of a suspension formed from a liquid culture means or eugonic medium in which the biological sample is inoculated, and in which the turbidity is continuously measured directly from the suspension of the sample analyzed during the growth step of the bacteria, until a determined threshold of turbidity is reached expressed according to the McFarland standard. | 12-15-2011 |
20110307184 | LOW PERFUSION SIGNAL PROCESSING SYSTEMS AND METHODS - In some embodiments, systems and methods for identifying a low perfusion condition are provided by transforming a signal using a wavelet transform to generate a scalogram. A pulse band and adjacent marker regions in the scalogram are identified. Characteristics of the marker regions are used to detect the existence of a lower perfusion condition. If such a condition is detected, an event may be triggered, such as an alert or notification. | 12-15-2011 |
20110313672 | CELLULAR ANTIOXIDANT ACTIVITY (CAA) ASSAY - A cellular antioxidant activity (CAA) assay for quantifying the antioxidant activity of phytochemicals, food extracts, and dietary supplements has been developed. Dichlorofluorescin is a probe that is trapped within cells and is easily oxidized to fluorescent dichlorofluorescein (DCF). The method measures the ability of compounds to prevent the formation of DCF by 2,2′-azo-bis(2-amidinopropane) dihydrochloride (ABAP)-generated peroxyl radicals in human hepatocarcinoma HepG2 cells. The decrease in cellular fluorescence when compared to the control cells indicates the antioxidant capacity of the compounds. The antioxidant activities of selected phytochemicals and fruit extracts were evaluated using the CAA assay and the results were expressed in μ-mol quercetin equivalents/100 μ-mol phytochemical or μ-mol quercetin equivalents/100 g fresh fruit. Quercetin had the highest CAA value, followed by kaempferol, epigallocatechin gallate (EGCG), myricetin, and luteolin among the pure compounds tested. Among the selected fruits tested, blueberry had the highest CAA value, followed by cranberry>apple=red grape>green grape. The CAA assay is a more biologically relevant method than the popular chemistry antioxidant activity assays because it accounts for aspects of uptake, metabolism, and location of species within cells. | 12-22-2011 |
20110313673 | METHODS AND APPARATUS FOR DECENTRALIZED DIABETES MONITORING - Methods for decentralized monitoring of a progression of a diabetic state of a patient include contemporaneously obtaining an initial set of venous blood samples and an initial set of capillary blood samples after a standardized metabolic challenge from the patient in a centralized setting, wherein the diabetic state is diagnosed using the initial set of venous blood samples and a first test baseline is established by correlating the initial set of capillary blood samples with the initial set of venous blood samples, implementing a therapy, performing decentralized testing after reaching a target event, wherein a status test is obtained from a status set of capillary blood samples obtained from the patient after a subsequent standardized metabolic challenge, and comparing the status test with the first test baseline to determine an effectiveness of the therapy. | 12-22-2011 |
20110313674 | INSULIN OPTIMIZATION SYSTEMS AND TESTING METHODS WITH ADJUSTED EXIT CRITERION ACCOUNTING FOR SYSTEM NOISE ASSOCIATED WITH BIOMARKERS - Embodiments of a testing method for optimizing a therapy to a diabetic patient comprise collecting at least one sampling set of biomarker data, computing a probability distribution function, a hazard function, a risk function, and a risk value for the sampling set of biomarker data wherein, wherein the probability distribution function is calculated to approximate the probability distribution of the biomarker data, the hazard function is a function which yields higher hazard values for biomarker readings in the sampling set indicative of higher risk of complications, the risk function is the product of the probability distribution function and the hazard function, and the risk value is calculated by the integral of the risk function, minimizing the risk value by adjusting the diabetic patient's therapy, and exiting the testing method when the risk value for at least one sampling set is minimized to an optimal risk level. | 12-22-2011 |
20110313675 | RAPID DIAGNOSIS OF A DISEASE CONDITION USING INFRARED SPECTROSCOPY - Reliable and rapid diagnostic methods for many functional syndromes (FS) such as Bladder Pain Syndrome/Interstitial Cystitis (IC) are not available. Exemplary embodiments include rapid and accurate methods for diagnosing FS in humans and other mammals using infrared microspectroscopy (IRMS). Exemplary methods utilize Soft Independent Modeling by Class Analogy (SIMCA) to create classification models. Exemplary methods utilize classification models to categorize a subject's condition (e.g., healthy/sick and or flare/remission). Using these classification models, various embodiments enable diagnosis based on spectra data from a blood sample or other biomedical specimen. Exemplary embodiments may be useful for rapid diagnosis of IC and various other conditions in humans, cats, and/or other mammals. | 12-22-2011 |
20110313676 | Methods, Systems, and Media for Identifying Transcription Factor Binding Sites - Provided are systems, methods, and media that receive chromosome sequence data; select a first plurality of overlapping octamers from the chromosome sequence data; assign an enrichment score to each of the first plurality of overlapping octamers to produce a first set of enrichment scores; calculate a first average of the first set of enrichment scores; determine whether the first average is above a threshold; select a second plurality of overlapping octamers from the chromosome sequence data; assign an enrichment score to each of the second plurality of overlapping octamers to produce a second set of enrichment scores; calculate a second average of the second set of enrichment scores; determines whether the second average is above the threshold; and output data that indicates that a transcription factor binding site has been identified in connection with at least one of the first plurality of octamers and the second plurality of octamers. | 12-22-2011 |
20110313677 | METHOD FOR DETERMINING THE LIVER PERFORMANCE OF A LIVING ORGANISM BY THE MEANS OF QUANTITATIVE MEASURING THE METABOLIZATION OF SUBSTRATES - A method for determining the liver performance of a living organism, in particular a human, comprising administering at least one | 12-22-2011 |
20110313678 | PROBES AND METHODS FOR DETERMINING THE PRESENCE OR ABSENCE OF GENETIC SEGMENTS - A method for determining the presence or absence of a genetic segment of interest, such as an exon, an intron or a promoter, in a DNA-containing sample, and probe sets for use in such methods, including probe sets comprising oligonucleotide probes having nucleotides sequences selected from those of SEQ ID NOS: 1-101. | 12-22-2011 |
20110313679 | APPARATUS, METHOD AND COMPUTER-READABLE STORAGE MEDIUM FOR EVALUATING A PHYSIOLOGICAL CONDITION OF A PATIENT - A method is provided that includes receiving measurements of biological elements from a blood sample of a patient. The respective biological elements are managed by the endocrine system, which is organizable in axes including a corticotropic axis, gonadotropic axis, thyreotropic axis and somatotropic axis. The method includes calculating a plurality of indexes as functions of the measurements. The indexes reflect physiological relationships between the biological elements and the hormones that manage the respective biological elements, and at least some of the indexes reflect physiological relationships between hormones across axes of the endocrine system. The method also includes evaluating the indexes by axis of the endocrine system to facilitate identification of one or more dysfunctions capable of participating in the genesis, installation and evolution of a pathology, and thereby formulate a diagnosis of the patient. And the method includes administering a therapy to the patient in accordance with the diagnosis. | 12-22-2011 |
20110313680 | Health Monitoring System - A machine for processing continuous glucose monitoring data and issuing an alert if hypoglycemia is imminent has three modules: (a) a pre-processing module that receives and modulates continuous glucose monitoring data by reducing noise and adjusting for missed data points and shifts due to calibration; (b) a core algorithm module that receives data from the pre-processing module and calculates a rate of change to make a hypoglycemia prediction, and determine if hypoglycemia is imminent; and (c) an alarm mode module that receives data from the core algorithm and issues an audio or visual alert or warning message or a negative feedback signal to an insulin delivery device if hypoglycemia is imminent. | 12-22-2011 |
20110313681 | BIOMARKERS FOR PERIPHERAL ARTERY DISEASE - This invention provides biomarkers whose concentrations in blood plasma are associated with the presence or absence of PAD in the patient from whom the plasma sample is taken. The invention also provides biomarkers for distinguishing between PAD patients who are long claudicators and PAD patients who are not. In addition, the invention provides methods for identifying additional biomarkers, methods for detecting the biomarkers in patients, and methods for identifying agents, including pharmaceutical agents, which interact with the biomarkers and are useful for preventing or treating PAD in patients. | 12-22-2011 |
20110320130 | SYSTEMS AND METHODS FOR COMMUNICATING SENSOR DATA BETWEEN COMMUNICATION DEVICES - System and method for communicating glucose concentration information between devices of a continuous glucose monitoring system is provided. The continuous glucose monitoring system can include a sensor module generates a glucose concentration measurement data and transmits the data to one or more further devices of the continuous glucose monitoring system. The further devices can include a receiver unit and one or more secondary display devices. The receiver unit can be configured to be a stand-alone device of or physically connect to a secondary display device. A user interface can also be provided that provides enhanced functionality for using the continuous glucose monitoring system. | 12-29-2011 |
20110320131 | BIOLOGICAL INFORMATION PROCESSING APPARATUS, BIOLOGICAL INFORMATION DISPLAY APPARATUS, TELEMEDICAL SYSTEM, TELEMEDICAL METHOD, PROCESSING CONTROL PROGRAM, DISPLAY CONTROL PROGRAM, AND STORAGE MEDIUM - In order that a telemedical system which can take into account reliability of data from a patient is provided, a patient-side terminal in the telemedical system is connected with a server via a communications network, and includes a communication section which obtains first biological information indicating a physiological state of a user from a sensing apparatus which measures a physiological state of a user, an input section which accepts an input from a user so as to obtain second biological information, and a control section which (i) adds, to the first biological information, first distinguishing information indicating that the first biological information is information obtained by the communication section, and (ii) adds, to the second biological information, second distinguishing information indicating that the second biological information is information obtained by the input section, so that the first biological information and the second biological information are distinguished from each other. The communication section transmits the distinguishable first and second biological information to the server. | 12-29-2011 |
20120004851 | FIELD-PORTABLE IMPEDANCE READER AND METHODS OF MAKING THE SAME - A field-portable impedance reader is provided. The impedance reader comprises a reader antenna, an impedance compensator, a calibrator, and a synchronous sampler. The impedance reader further comprises a digital processor that receives and processes signals from the synchronous sampler. Further, a wireless system comprising the impedance reader of the invention is provided. | 01-05-2012 |
20120004852 | HAND HELD ANALYSIS DEVICE FOR ANALYZING A BODY FLUID AND A CONTROL METHOD THEREFOR - A method is provided for controlling a hand-held analysis device for analyzing a body fluid in which in each case at least one test means for single use is automatically provided in consecutive measuring cycles by means of a control device where each measuring cycle in a measuring mode of the control device is triggered by a start actuation. According to the invention it is proposed that a defined control intervention puts the control device into a maintenance mode in which the automatic provision of a test means is prevented. | 01-05-2012 |
20120004853 | Analysis System And Computer Implemented Method For Analyzing Biological Samples - Analysis system and computer implemented method for analyzing biological samples are disclosed. The system has at least one analyzer for performing an analysis and a decision unit being operable to determine in response to the receipt of the analysis request whether results obtained from performing the analysis on the sample indicated in the analysis request are valid. This determination is executed by retrieving the meta information assigned to the sample and by applying the at least one condition on the meta information and wherein the at least one applied condition has at least a condition on whether the sample allows a valid analysis on the sample, and wherein the decision unit returns the decision that the analysis exercised on the indicated sample will return a valid result in case the conditions of the condition set are met by the sample. | 01-05-2012 |
20120004854 | METABOLIC BIOMARKERS FOR OVARIAN CANCER AND METHODS OF USE THEREOF - Panels of serum metabolic biomarkers and methods of their use in detecting and diagnosing cancer, especially ovarian cancer, are disclosed. The metabolic biomarker panels include 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 50, 75, 100, 150, or more metabolites. Supervised classification methods, such as trained support vector machines (SVMs) are used to determine whether the levels of metabolic biomarkers in a subject are indicative of the presence of cancer. The disclosed biomarkers and methods preferably allow a diagnosis of cancer with an accuracy, a specificity, and/or a sensitivity of at least 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99%. | 01-05-2012 |
20120004855 | METHYLATION BIOMARKERS FOR PREDICTING RELAPSE FREE SURVIVAL - A methylation classification list comprising loci DNA, for which loci the methylation status of the DNA is indicative of likelihood of recurrence of cancer, is provided. Furthermore, a method, apparatus and use for predicting probability of relapse free survival of a subject diagnosed with cancer, are provided. | 01-05-2012 |
20120004856 | SPECTRAL DATA ANALYZER, BIOLOGICAL SUBSTANCE DETECTION SYSTEM, AND BIOLOGICAL SUBSTANCE DETECTION METHOD - A spectral data analyzer is disclosed. The spectral data analyzer calculates the spectral intensity ratio of a C—H band and an amide I band in a Raman spectrum that corresponds to a substance present in a body tissue; and automatically determines the presence or absence of amyloid beta in the substance based on the calculated ratio. | 01-05-2012 |
20120004857 | THROUGHPUT INFORMATION GENERATING APPARATUS OF SAMPLE ANALYZER, SAMPLE ANALYZER, THROUGHPUT INFORMATION GENERATING METHOD OF SAMPLE ANALYZER, AND COMPUTER PROGRAM PRODUCT - An apparatus for generating throughput information of a sample analyzer is disclosed. Specifically, this apparatus generates throughput information of a sample analyzer capable of measuring a sample on a plurality of measurement items in which measurement time differs from each other. The apparatus receives an input of a plurality of measurement orders, wherein a measurement order includes a designation of at least one measurement item, generates the throughput information of the sample analyzer based on the received plurality of measurement orders; and outputs the generated throughput information. | 01-05-2012 |
20120004858 | SYSTEM FOR ANALYZING EXPRESSION PROFILE, AND PROGRAM THEREFOR - The present invention provides a system for analyzing an expression profile in which a large number of expression profile data obtained by a next-generation high-speed sequencer, a similar experimental technique, or the like is analyzed at high speed by a general-purpose computer, gene expression patterns are visualized, thereby easily analyzing to which gene a novel gene is similar in function. A system for analyzing an expression profile which analyzes gene expression profile data includes a storage unit which stores the number of counts of mRNAs expressed from a subject gene to be evaluated as expression data under each of a plurality of gene expression conditions for each subject gene name, a correspondence analysis unit which reads the expression data from the storage unit for each subject gene, and carries out correspondence analysis on the basis of the number of counts under each expression condition in expression data, a coordinate conversion unit which converts n-dimensional (n: natural number) scores obtained by the correspondence analysis to coordinate values for m-dimensionally (m: natural number, m≦n) arranging each subject gene, and an image processing unit which carries out plotting along the corresponding coordinate values for each gene to display the result on an image display unit. | 01-05-2012 |
20120010821 | Nucleic Acid Abundance Ratio Measurement Device, Method, and Program Storage Medium, Determination Method and Nucleic Acid Abundance Ratio Measurement Kit - A nucleic acid abundance ratio measurement device includes a detection section that detects a detection signal over different temperature ranges of a melting curve for a nucleic acid mixture having one or more melting temperatures, and an abundance ratio computation section that computes a nucleic acid abundance ratio based on a ratio of characteristic amounts obtained from the detection signal detected by the detection section and based on detection amount data. | 01-12-2012 |
20120010822 | FLUORESCENCE INTENSITY COMPENSATION METHOD AND FLUORESCENCE INTENSITY CALCULATION DEVICE - A fluorescence intensity compensation method, includes: receiving, with photodetectors having different input wavelength bands, fluorescence emitted from fluorochromes excited by irradiating light on microparticles multiply-labeled by a plurality of fluorochromes with overlapping fluorescence wavelengths; collecting detected values for the photodetectors; and obtaining a measurement spectrum, by approximating, from the linear sum of single-stain spectrums obtained from microparticles individually labeled with the fluorochromes; wherein approximation of the measurement spectrum by the linear sum of the single-stain spectrums is performed using the restricted least-square method. | 01-12-2012 |
20120016593 | METHOD AND APPARATUS FOR WORLDWIDE SREENING FOR HUMAN PAPILLOMA VIRUS - The invention relates to in vitro methods of screening female human subjects for the presence of human papillo mavirus, for example as a marker of cervical epithelial precancer. In particular, the invention provides methods and apparatus which can be used to filter a patient data set of measurements related to multiple HPV types according to the geographical location of the patient under test, so that only those measurements of HPV types which are pre-determined to be relevant for the geographical region in which the patient under test is located are selected for output/display. | 01-19-2012 |
20120016594 | METHOD FOR TRANSLATING GENETIC INFORMATION FOR USE IN PHARMACOGENOMIC MOLECULAR DIAGNOSTICS AND PERSONALIZED MEDICINE RESEARCH - A gene-drug specific system for classifying individual genetic variants based on strength-of-evidence of clinical utility from published scientific and clinical data that support their effect on modifying drug response and behavior. This allows categorization of the genetic variants into evidence classes that have a wide range of uses such as pharmacogenomic molecular diagnostics and personalized medicine research designed to guide the clinical implementation of PGx. Furthermore, this information can be combined with a knowledgebase of drug-response phenotypes, a knowlegebase of specific drug-induced outcomes and individual patient diplotype information for a gene-drug combination into a programmed computer to output corresponding patient-specific predicted drug responses. | 01-19-2012 |
20120016595 | TRANSCRIPT MAPPING METHOD - A transcript mapping method according to an embodiment of the invention is described hereinafter and combines short tag based (SAGE and MPSS) efficiency with the accuracy of full-length cDNA (flcDNA) for comprehensive characterization of transcriptomes. This method is also referred to as Gene Identification Signature (GIS) analysis. In this method, the 5′ and 3′ ends of full-length cDNA clones are initially extracted into a ditag structure, with the ditag concatemers of the ditag being subsequently sequenced in an efficient manner, and finally mapped to the genome for defining the gene structure. As a GIS ditag represents the 5′ and 3′ ends of a transcript, it is more informative than SAGE and MPSS tags. Segment lengths between 5′ and 3′ tag pairs are obtainable including orientation, ordering and chromosome family for efficient transcript mapping and gene location identification. Furthermore, a compressed suffix array (CSA) is used for indexing the genome sequence for improve mapping speed and to reduce computational memory requirements. | 01-19-2012 |
20120016596 | BIOLOGICAL INFORMATION MANAGEMENT SYSTEM AND BIOLOGICAL INFORMATION MANAGEMENT METHOD - A measurement result management system suited for storing biological information measured with a measuring equipment in a server is provided. The measurement result management system includes a measuring equipment for measuring and transmitting biological information, and a server for receiving the biological information from the measuring equipment and storing the same, wherein the measuring equipment performs a step of transmitting authentication related information related to authentication of the measuring equipment when transmitting the biological information with a communication unit, and the server performs a step of carrying out authentication based on the authentication related information, and steps of storing the biological information acquired through a communication unit in a storage unit regardless of whether the authentication result of the step of carrying out authentication based on authentication related information is positive or negative. | 01-19-2012 |
20120022792 | METHOD OF QUANTIZATION OF MAGNETIC NANOPARTICLE ABSORPTION INTO ANIMAL TISSUES, AND EQUIPMENT FOR DOING IT - A method of quantization of magnetic nanoparticle absorption in animal tissues includes determination of the number of magnetic nanoparticles absorbed in animal tissues by magnetization measurements. The method is based on the measurement of magnetization versus magnetic field applied of the tissue sample absorbed with the nanoparticles obtaining their saturation magnetization. This magnitude is compared to the saturation magnetization of the same nanoparticles found in the tissue for the determination of the absolute number of magnetic nanoparticles in the animal tissue studied. The method includes preparing the samples for the sample holder, measuring the magnetization vs. applied magnetic field of a known number of magnetic nanoparticles, determining the saturation magnetization of the sample to be studied by measuring the magnetization and calculating the nanoparticle mass in the tissues from the data measured (saturation magnetization of the sample and of calibration of nanoparticles). | 01-26-2012 |
20120022793 | BIOMARKERS FOR THE DIAGNOSIS OF PROSTATE CANCER IN A NON-HYPERTENSIVE POPULATION - The present invention includes the use of biomolecules for differential diagnosis of prostate cancer and/or non-malignant disease of the prostate. The present invention also provides methods for detecting biomolecules within a biological sample. The invention further includes kits for differential diagnosis of prostate cancer and/or non-malignant disease of the prostate in a biological sample. | 01-26-2012 |
20120029829 | Light Focusing Continuous Wave Photoacoustic Spectroscopy And Its Applications To Patient Monitoring - The present disclosure describes systems and methods that use spatial modulation to focus continuous wave light into a localized region of interest such as an individual blood vessel. In certain embodiments, intensity modulation techniques, such as linear frequency modulation, are used in conjunction with spatial modulation to achieve more precise measurements through otherwise scattering medium. The focused beam of continuous wave light is capable of penetrating several centimeters of tissue to deliver measurements and images associated with individual blood vessels and other discrete vascular components. | 02-02-2012 |
20120029830 | BLOOD GLUCOSE MEASUREMENT DEVICES AND METHODS OF USING THE SAME - Blood glucose measurement devices and methods of using the same. In at least one exemplary embodiment of a device of the present disclosure, the device comprises a main housing sized and shaped to receive a lancet assembly and a test strip holder, a circuit board positioned within the main housing, the circuit board capable of producing data indicative of a test strip fluid, and a processor operably coupled to the circuit board, the processor capable of receiving and processing the data from the circuit board and displaying a processed result on a screen. | 02-02-2012 |
20120029831 | FLUORESCENCE DETECTING DEVICE AND FLUORESCENCE DETECTING METHOD - A fluorescence detecting device receives fluorescence emitted by n kinds of measurement objects within wavelength bands FL | 02-02-2012 |
20120029832 | Apparatus and method for distribution of biological material - A new approach is proposed that contemplates systems and methods to support improved means for handling of biological materials, for example biological samples or products used in biological or biomedical research, diagnostics or therapy. In particular, the proposed approach provides improved means for handling patient samples and products used in regenerative medicine, such as biological or biochemical products or cell products. Improvements in for example, the ability to culture, process, distribute or preserve, i.e. increase the usable life of biological products, including cell products, in regenerative medicine would enable more widespread use of such products and uptake of regenerative medicine procedures. | 02-02-2012 |
20120035855 | METHOD OF NETWORK-BASED IDENTIFICATION FOR DRUG ACTION AND/OR SYNERGY EFFECT OF MEDICINE COMBINATION - The invention provides a network-based method for confirming drug action (drug effect, synergistic reaction). The method be carried out by mapping a first drug genes/gene products subset and a second genes/gene products subset in a gene network. The second genes/gene products subset can be a second drug genes/gene products subset or a biological process genes/gene products subset. The invention also provides a tool for pre-clinical drug screening. | 02-09-2012 |
20120035856 | METHOD FOR THE DISCOVERY, VALIDATION AND CLINICAL APPLICATION OF MULTIPLEX BIOMARKER ALGORITHMS BASED ON OPTICAL, PHYSICAL AND/OR ELECTROMAGNETIC PATTERNS - A method for determining multiplex biomarker algorithms based on optical, physical and/or electromagnetic patterns, and applying the multiplex biomarker algorithms so as to provide a single diagnostic result indicative of a medical condition, the method comprising:
| 02-09-2012 |
20120035857 | COMPUTER-IMPLEMENTED BIOLOGICAL SEQUENCE IDENTIFIER SYSTEM AND METHOD - A computer-implemented biological sequence identifier (CIBSI) system and method for selecting a subsequence from biological sequence data according to at least one selection parameter. The at least one selection parameter corresponds to a likelihood of returning a meaningful result from a similarity search. | 02-09-2012 |
20120035858 | DEVICE FOR ELECTRICALLY MEASURING AT LEAST ONE PARAMETER OF A MAMMAL'S TISSUE - The device measuring a parameter p that depends on the real and/or imaginary parts of the permittivity of body tissue operates at a frequency f where a temperature change affects the permittivity of free water only weakly. If the parameter p depends on the real part of the permittivity only, the frequency f should be between 6.2 and 10.1 GHz. If the parameter p depends on the imaginary part of the permittivity only, the frequency f should be between 25.5 and 36 GHz. If parameter p depends on the real and imaginary parts of the permittivity, the derivative of the parameter in respect to the real and imaginary parts of permittivity can be used to calculate an optimum frequency range. | 02-09-2012 |
20120035859 | METHOD AND APPARATUS FOR MULTI-PARAMETER DATA ANALYSIS - In one aspect, the present invention relates to a method | 02-09-2012 |
20120041683 | Pathway recognition algorithm using data integration on genomic models (PARADIGM) - The present invention relates to methods for evaluating the probability that a patient's diagnosis may be treated with a particular clinical regimen or therapy. | 02-16-2012 |
20120041684 | Method of evaluating obesity, obesity-evaluating apparatus, obesity-evaluating method, obesity-evaluating system, obesity-evaluating program product, recording medium, and information communication terminal apparatus - According to the method of evaluating obesity of the present invention, amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated is measured, and the state of at least one of the apparent obesity, the non-apparent obesity and the obesity which are defined by the BMI and the VFA in the subject is evaluated based on the concentration value of at least one of Glu, Ser, Pro, Gly, Ala, Cys2, Tyr, Val, Orn, Met, Lys, Ile, Leu, Phe, and Trp contained in the measured amino acid concentration data of the subject. | 02-16-2012 |
20120041685 | SYSTEM AND METHOD FOR ESTIMATING RADIATION DOSE AND DISTRIBUTION USING MEDIUM-DEPENDENT-CORRECTION BASED ALGORITHMS (MDC) - Systems and methods for accurately calculating radiation doses in biological tissues exposed to a radiation source are provided. In the systems and methods first, a radiation dose is computed to geometry of water equivalent medium of the biological tissues, expressed in computed tomography (CT) volumetric images. A Medium-Dependent-Correction factor that is a function of an effective bone depth matrix and the incident x-ray beam is obtained and tabulated. Using patient material and density data derived from CT images, the effective bone thickness can be calculated from a specific x-ray source. Finally, a Medium-Dependent-Correction factor that is a function of an effective bone depth matrix is used to accurately determine the radiation dose distributions to biological tissues. | 02-16-2012 |
20120046872 | Method and Arrangement for the Control of Measuring Systems, Corresponding Computer Program and Corresponding Computer-Readable Storage Medium - Disclosed herein is a method and an arrangement for the control of measuring systems such as a mass spectrometer or nuclear magnetic resonance (NMR) instrument, the control being based on an online data analysis of the current measurements. Depending on the measurement experiment, the combined result of the data analysis can have either a direct influence on the next measurement or result in a dynamically organized sequence of measurements. The measuring systems may be controlled by establishing a database that comprises information on the objects to be measured, the measurement data which can be detected during the measurement experiments using the measuring systems, and information regarding the relationships between or among items of the measurement data. | 02-23-2012 |
20120046873 | HAIRSCAN FOR GROWTH ANALYSIS - Effectiveness of a therapeutic regimen applied to hair follicles is determined by establishing a baseline cross-sectional dimension of a first cross-sectional portion of a hair shaft that is acquired from a target area of a patient. A post-therapeutic cross-sectional dimension of a second cross-sectional portion of a hair shaft that is acquired from the target area of a patient subsequent in time to the acquisition of the first cross-sectional portion of a hair shaft and to an application of a therapeutic agent to a hair follicle that generated the second cross-sectional hair shaft portion, is also determined. Thus, a difference between the baseline and post-therapeutic cross-sectional dimensions is determined and used to automatically revise a therapeutic regimen frequency, duration, or duty cycle for an application of the therapeutic agent applied to the hair follicle that generated the post-therapeutic hair shaft portion. | 02-23-2012 |
20120046874 | CONSIDERATION OF EVIDENCE - A computer implemented method of comparing a test sample result set with another sample result set is provided, the method including: providing information for the first result set on the one or more identities detected for a variable characteristic of DNA; providing information for the second result set on the one or more identities detected for a variable characteristic of DNA; and comparing at least a part of the first result set with at least a part of the second result set; and wherein: the comparing includes a likelihood and the likelihood uses a probability density function conditioned on DNA quantity. Further benefits are obtained from the manner in which the probability density function is obtained and/or the use of probability density functions to account for stutter and/or allele dropout. | 02-23-2012 |
20120046875 | METHOD AND SYSTEM FOR PROCESSING A PHYSIOLOGICAL SIGNAL - A method of signal processing, includes obtaining at least one physiological signal from a system ( | 02-23-2012 |
20120046876 | Computational methods and systems for suggesting modulators of CYP450 as treatment options - Computational methods and systems are described which accept input, identify one or more CYP450-family enzymes, identify one or more modulators of the CYP450-family enzymes, and communicate treatments to at least one system user, wherein the treatments include one or more of the identified at least one modulator. | 02-23-2012 |
20120059593 | Method for Determining the Stroke Volume of a Heart, Method for Determining the Electrode Positions Therefor, and Sheet Shaped Device Therefor - Method for determining the stroke volume of a heart comprising: attaching electrodes to the front legs or arms or head, and the hind legs of the body; connecting an alternating current source to the left pair of front legs/arms or head, and hind legs; connecting an alternating current source to the right pair of front legs/arms or head, and hind legs; attaching a number of electrode pairs to the thoracic skin, such that the electrodes are in contact with the skin of the thorax at predetermined positions, wherein the electrode pairs are each connected to an independent input of a data acquisition/calculation device; determining the beginning the cardiac cycle and measuring with the number of electrode pairs on the thorax the voltage at the beginning of the cardiac cycle at the predetermined positions; measuring during the cardiac cycle with the number of electrode pairs on the thorax the voltages at the predetermined positions and determining the voltage changes V | 03-08-2012 |
20120059594 | COMPOSITIONS AND METHODS FOR DISCOVERY OF CAUSATIVE MUTATIONS IN GENETIC DISORDERS - The compositions and methods provided herein allow for identification of causative genetic biomarkers for a disease condition or drug response. | 03-08-2012 |
20120059595 | SYSTEM AND METHOD FOR HIGH-CONTENT ONCOLOGY ASSAY - The present invention provides an apparatus, system, method and computer program and computer program product for analyzing cellular samples. One embodiment of the apparatus and method provides a multiparameter assay that provides information with respect to cell proliferation, cell cycling and cell death. The multiparameter assay is particularly useful for assessing and screening candidate compounds for anti-cancer utility. | 03-08-2012 |
20120059596 | SYSTEM AND METHOD FOR DETERMINING A DOSAGE FOR A TREATMENT - An system and method for allowing the real-time diagnostics of various genotype-related treatments while allowing for the changing of demographic data such as a person's age, weight, etc. Various embodiments and methods of new processes include the assembly and association of genetic material samples, the preparation of microarrays with representative genetic material samples in a pattern best suited for analysis as well as manipulation, and delivery of assimilated and compiled data in the form of an electronic document for determining a dosage for a treatment. | 03-08-2012 |
20120059597 | Computational methods and systems for treatment in relation to modulation of CYP450 enzyme activity - Methods and systems such as those described herein include accepting input, identifying CYP450-family enzymes, identifying at least one modulator of an enzyme, and communicating one or more treatments to a system user. | 03-08-2012 |
20120065892 | SCORING SYSTEM FOR THE PREDICTION OF CANCER RECURRENCE - The present invention relates to a scoring system for the prediction of cancer recurrence by selecting genes and/or proteins whose expression patterns associated with recurrence of cancer, and generating formulae with the selected genes and/or proteins for the prediction of cancer recurrence. The present invention relates to a kit for determining the likelihood of recurrence of cancer, comprising DNA chip, oligonucleotide chip, protein chip, peptides, antibodies, probes and primers that are necessary for effecting DNA microarrays, oligonucleotide microarrays, protein arrays, northern blotting, in situ hybridization, RNase protection assays, western blotting, ELISA assays, reverse transcription polymerase-chain reaction to examine the expression of at least 2, 4, 6, 10, 12 or more genes and/or proteins, that are indicative of cancer recurrence. | 03-15-2012 |
20120065893 | Method and apparatus for mitigating aviation risk by determining cognitive effectiveness from sleep history - Method and apparatus for analyzing and managing fatigue primarily in but not limited to aviation occupations. The invention is adaptable to other occupations where assuring crew rest is critical. Graphical user interfaces (GUIs) allow for the insertion of sleep quantity, quality, and sleep interruptions over a number of days. The invention produces as an output the user's cognitive effectiveness ranging from high levels to critically low levels over a period of days. | 03-15-2012 |
20120065894 | MEDICAL SYSTEM AND METHOD FOR PROVIDING GLYCEMIC CONTROL BASED ON GLYCEMIC RESPONSE INFORMATION - A medical device for providing information for glycemic control is provided, wherein the device comprises a storage unit arranged to store information on an initial dose of insulin and to store information on a blood glucose level measured after the initial dose of insulin was administered and after specific food was consumed, and a determining unit arranged to determine a subsequent dose of insulin to be administered before the specific food is consumed based at least on said information on the initial dose of insulin and said information on the blood glucose level. | 03-15-2012 |
20120065895 | METHOD FOR MONITORING AN INDIVIDUAL'S FAT METABOLISM STATE - Method of monitoring energy consumption of an individual in an information system, comprised of periodically determining the energy balance of the individual by measuring body fat percentages (or body fat mass) at least at three consecutive moments of time and calculating change of body fat percentages (body fat mass) from two consecutive moments of time, and calculating the trends of the individual's energy balance from the changes of body fat percentages (body fat mass) and determining from the trend whether the individual is in the stage of burning or accumulating fat. The information system automatically generates recommendations for controlling energy balance based on the trends of changes of the energy balance. | 03-15-2012 |
20120065896 | BIOLOGICAL AND CHEMICAL TEST MEDIA AND SYSTEM - An apparatus and method for performing medical, biological or chemical tests in the field is disclosed. In some embodiments, the test media comprises a special purpose optical disc which is read, after application of the test specimen and subsequent processing, using commonly available CD, DVD, High Definition DVD or Blu-Ray optical disc players. | 03-15-2012 |
20120065897 | PREDICTING RISK OF MAJOR ADVERSE CARDIAC EVENTS - Measurement of circulating ST2 and natriuretic peptide (e.g., NT-proBNP) concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, transplantation, and heart failure. | 03-15-2012 |
20120072118 | VARIATION ANALYSIS FOR MULTIPLE TEMPLATES ON A SOLID SUPPORT - Disclosed herein are compositions and methods used for detecting different types of molecules associated with a site on a solid support. | 03-22-2012 |
20120072119 | Methods To Diagnose Treat and Prevent Bone Loss - Methods of diagnosing and preventing bone loss and/or enhancing bone formation are disclosed. The invention additionally provides methods of diagnosing a predisposition to bone loss. The methods mathematically combine the information provided by imaging tests with the information provided by biomarkers to provide an index value. The index value is used for diagnosis of bone diseases, and to assess the progress of treatment of bone diseases. | 03-22-2012 |
20120072120 | AUTOMATIC THRESHOLD SETTING AND BASELINE DETERMINATION FOR REAL-TIME PCR - The invention discloses a system and methods for quantitating the presence of nucleic acid sequences by evaluation of amplification data generated using real-time PCR. In one aspect, the methods may be adapted to identify a threshold and threshold cycle for one or more reactions based upon evaluation of exponential and baseline regions for each amplification reaction. The methodology used in the analysis may be readily automated such that subjective user interpretation of the data is substantially reduced or eliminated. | 03-22-2012 |
20120072121 | SYSTEMS AND METHODS FOR QUALITY CONTROL OF COMPUTER-BASED TESTS - Disclosed are systems and methods for monitoring, inter alter, administration compliance, test subject identity, and results quality of computer-administered tests. A test administration unit, an audio-visual data collection unit, and an audio-visual data processing unit are configured to detect testing anomaly events within the testing environment by analyzing audiovisual data from the test subject and environment itself. Disclosed methods include modifying or amending test results because of detected testing anomaly events within the testing environment, verifying the identity of the test subject, and monitoring for compliance with test-administration protocols. Additional methods disclosed include: user facial analysis, including gaze point analysis, for indirect detection of testing anomaly events; user verification using facial recognition, voice recognition, retinal scans, and or other audiovisual biometric protocols; and the like. | 03-22-2012 |
20120072122 | Forensic Integrated Search Technology - A system and method to search spectral databases and to identify unknown materials. A library comprising sublibraries is provided, each sublibrary containing a plurality of reference data sets corresponding to known materials. Test data sets are provided, characteristic of an unknown material. Each test data set is generated by one or more spectroscopic data generating instruments. Each sublibrary is searched and a corresponding set of scores is produced, indicating a likelihood of a match. Relative probability values are calculated for each searched sublibrary. All relative probability values are fused producing a set of final probability values, used to determine whether the unknown material is represented through a known material in the library. A highest final probability value is selected compared to a minimum confidence value. If the probability value is greater than or equal to the minimum confidence value, the known material is reported. | 03-22-2012 |
20120072123 | Methods of Predicting The Probability of Modulation of Transcript Levels By RNAI Compounds - The present invention provides a method for determining the probability that an RNAi compound modulates the expression level of a gene using a linear regression model. The present invention also provides a method for determining the probabilities that an RNAi compound modulates the expression levels of each gene in a set of genes of interest using the linear regression model. The present invention provides a method for determining the seed-sequence-dependent signature size of an RNAi compound using the linear regression model. The invention provides a method for identifying genes having seed-sequence-dependent silencing effect by an siRNA using the linear regression model. The invention further provides a method for selecting from a plurality of siRNAs one or more siRNAs with higher silencing efficacy, specificity and diversity in silencing a target gene in an organism. The invention also provides a method for determining the coefficients of the above linear regression model. | 03-22-2012 |
20120078521 | APPARATUS, SYSTEM AND METHODS FOR ASSESSING DRUG EFFICACY USING HOLISTIC ANALYSIS AND VISUALIZATION OF PHARMACOLOGICAL DATA - Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example method includes a computer-implemented method for assessing drug efficacy, comprising: accessing a first data set related to the performance of a target drug for a given indication; accessing a second data set related to a control for the indication; comparing the data for the target drug and the data for the control on at least one of a plurality of different metrics using a holistic analysis, wherein the at least one metric corresponds to an outcome associated with the indication and generating a corresponding report. An example apparatus/system includes a holistic analysis and viewing system to support the assessment of drug efficacy, said system comprising: a standardizer to at least one of standardize and normalize data related to drug development; a deviation analyzer to analyze said data based on at least one of a plurality of different efficacy metrics, wherein a quantified variation between a first data set of results corresponding to an identified target drug and a second data set of results corresponding to a control, wherein said first data set of results is provided for comparison with the second data set of results and the deviation therebetween is compared to the at least one efficacy metric. | 03-29-2012 |
20120078522 | SYSTEMS AND METHODS FOR HOLISTIC ANALYSIS AND VISUALIZATION OF PHARMACOLOGICAL DATA - Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example method includes accessing data related to drug development; pre-processing the data to prepare the data for measurement and analysis; and analyzing the data based on at least one of a plurality of different metrics. Each metric corresponds to a quantified variation between a first data set of results corresponding to a category in the drug development process. The first data set of results is provided for comparison with a second data set of results corresponding to at least one other category in the drug development process. At least some of the plurality of metrics are aggregated to generate a visual representation representing an integrated comparative visualization for the identified category. | 03-29-2012 |
20120078523 | METHODS FOR ISOLATION AND VIABILITY ASSESSMENT OF BIOLOGICAL ORGANISMS - Isolation of biological or chemical organisms can be accomplished using a surface enhanced Raman scattering (SERS) system. The SERS system can be a single or a stacked plurality of photonic crystal membranes with noble-metal lined through pores for flowing analyte potentially containing the biological or chemical organisms. The through pores can be adapted to trap individual biological or chemical organisms and emit SERS spectra, which can then be detected by a detector and further analyzed for viability of the biological or chemical organism. | 03-29-2012 |
20120078524 | System and method for diagnosis tissue samples using fluorescence and raman techniques - A system and method for determining a diagnosis of a test biological sample. A system comprising a first illumination source to illuminate a sample, a first detector for generating a fluorescence data set of said sample, a means for determining a region of interest, a second illumination source to illuminate said region of interest, a second detector to generate a Raman data set of said region of interest, and a means for determining a diagnosis of said sample. A method comprising illuminating a sample, generating a fluorescence data set of said sample, and assessing the fluorescence data set to identify a region of interest, illuminating a region of interest, and generating Raman data set. This Raman data set may be assessed to determine a diagnosis of the sample. A diagnosis may include a metabolic state, a clinical outcome, a disease progression, a disease state, and combinations thereof. | 03-29-2012 |
20120078525 | APPARATUS, SYSTEM AND METHODS FOR SELECTING DRUG CANDIDATES USING DISEASE SIGNATURE HOLISTIC ANALYSIS AND PHARMACOLOGICAL DATA - Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example method includes providing a first set of data corresponding to a drug of interest: providing a disease signature; providing a reference set of drug interaction data associated with the disease signature, comparing the first set of data to the reference set using a holistic analysis, and reporting the results of the comparison. An example of the apparatus includes, a standardizer to at least one of standardize and normalize drug interaction data related to a pre-selected disease signature: a deviation analyzer to compare the drug interaction data to data corresponding to a drug under review using a holistic analysis, and a reporter for reporting the output of the deviation analyzer. | 03-29-2012 |
20120078526 | APPARATUS, SYSTEM AND METHODS FOR DETERMINING DRUG ATTRIBUTES USING DISEASE SIGNATURE HOLISTIC ANALYSIS AND PHARMACOLOGICAL DATA - Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example of the inventive apparatus includes a standardizer to at least one of standardize and normalize data related to drug performance for a known disease signature; and a deviation analyzer to analyze said data based on at least one of a plurality of different efficacy metrics, wherein a quantified variation between a first data set of results corresponding to an identified target drug and a second data set of results corresponding to a control, wherein said first data set of results is provided for comparison with the second data set of results and the deviation therebetween is compared to the at least one efficacy metric associated with the disease signature. | 03-29-2012 |
20120078527 | KIT AND METHOD FOR PREDICTING SENSITIVITY OF GASTRIC CANCER PATIENT TO ANTI-CANCER AGENT - A kit and method for predicting the sensitivity of gastric cancer patient to an anti-cancer agent are disclosed. | 03-29-2012 |
20120078528 | PATIENT DIAGNOSIS USING DRUG RELATED HOLISTIC DATA - Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. A computer-implemented method for integrated comparative holistic analysis of drug development and related quantifiable patient treatment decision support for a medical condition having a known disease signature. | 03-29-2012 |
20120078529 | DETERMINING THE SEVERITY OF 5-FLUOROURACIL OVERDOSE - A severity score for 5-fluorouracil (5FU) toxicity is calculated by taking the square root of the sum of: (a) the square of the logarithm of the dose of 5-fluorouracil administered to the patient; and (b) the square of the logarithm of the administration rate of the 5-fluorouracil to the patient. | 03-29-2012 |
20120084010 | Dose Surface Method for Determination of Analyte Ratios - Methods, systems, and apparatus for accurately determining a proportion (ratio) of two analytes is provided, as well as provide a concentration of a first analyte from a determined concentration of a second analyte and from a proportion of the analytes to each other. In one aspect, a surface model (called a “dose surface” herein) relating the concentrations of the two analytes to the proportion can be used to obtain accurate values for one of the variables (e.g. a concentration or the proportion) when the other two variables have previously been obtained. The dose surface can be a three-dimensional surface and be non-linear. The dose surface model can include multiple regression functions. For example, measured responses can be individually converted to concentrations using two dose-response curves, and the concentrations can be input to a dose surface function to obtain the proportion. | 04-05-2012 |
20120084011 | METHODS FOR MANAGING CANCER PATIENT CARE - Methods for managing the care of a cancer patient are provided. Generally, the methods comprise calculating a risk score from characteristics obtained from a cancer patient with a plurality of nomograms comprising the characteristics and a plurality of competing risk factors, using a program to calculate risk scores; determining the patient's prognosis based on the risk score; and treating the patient with a regimen capable of improving the prognosis of a cancer patient having substantially the same risk score. Systems and computer readable media for practicing the methods are also provided. | 04-05-2012 |
20120084012 | METHOD FOR PREDICTING ACTIVATION ENERGY USING ATOMIC FINGERPRINT DESCRIPTOR OR ATOMIC DESCRIPTOR - The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors. Specifically, the invention provides a method of predicting the activation energy either for cytochrome P450-mediated hydrogen abstraction or for tetrahedral intermediate formation in cytochrome P450-aromatic hydroxylation using equations including effective atomic descriptors. | 04-05-2012 |
20120084013 | Software Integrated Cytometric Assay For Quantification Of The Human Polymorphonuclear Leukocyte FCyRI Receptor (CD64) - The invention relates a method of quantifying CD64 and CD163 expression in leukocytes and, specifically to a kit for use with a flow cytometer including a suspension of quantitative fluorescent microbead standards, fluorescent labeled antibodies directed to CD64 and CD163, and analytical software. The software is used to take information on the microbead suspension and fluorescent labeled antibodies from a flow cytometer and analyse data, smooth curves, calculate new parameters, provide quality control measures and notify of expiration of the assay system. | 04-05-2012 |
20120084014 | MODELING DEVICE, PROGRAM, COMPUTER-READABLE RECORDING MEDIUM, AND METHOD OF ESTABLISHING CORRESPONDENCE - A modeling device is disclosed that easily projects characteristic information obtained from an object onto a differently-shaped object, even if the object, from which the characteristic information is obtained, has a complex shape. A modeling device in one embodiment of the present invention includes a virtually electrifying section to calculate an electric potential at a spot in a heart at the time when a predetermined voltage is applied to the heart, and a projecting section to project a fiber orientation onto a heart model created on the basis of shape information that is input to the input section. The projecting section specifies a spot to be a target of projection on the basis of the electric potential obtained by the virtually electrifying section. Use of the electric potential in specifying the spot makes it possible to easily project the fiber orientation onto any heart having complex and various shapes. | 04-05-2012 |
20120084015 | Imaging Method and Use Thereof - The present invention relates to a method based on atomic force microscopy and the use thereof on biological surfaces. A method is provided to detect the Local Deviational Volume (LDV) of defined subcellular structures irrespective of a biochemical characterisation | 04-05-2012 |
20120089338 | COMPUTER IMPLEMENTED METHOD FOR INDEXING REFERENCE GENOME - A method for indexing a reference genome is provided. The method includes selecting a reference genome to index, calculating a first minimum index region size, assigning a first position number to a first index region of the reference genome, assigning a second position number to a second index region of the reference genome, and storing the association of the first and second position numbers to index regions in a hash table. The size of the first index region can be greater than or equal to the first minimum index region size. The second index region can overlap with at least one base included in the first index region. The first minimum index region size can be calculated based on the reference genome size. In yet other embodiments of the present teachings, a method for mapping a sequence read to a reference genome is provided wherein a sequence read is compared to the index regions stored in the indexing hash table, and the sequence read is mapped to and aligned against a location on the reference genome. Systems configured to carry out the methods are also provided. | 04-12-2012 |
20120089339 | METHOD AND SYSTEMS FOR PROCESSING POLYMERIC SEQUENCE DATA AND RELATED INFORMATION - Methods and systems for organizing, representing and processing polymeric sequence information, including biopolymeric sequence information such as DNA sequence information and related information are disclosed herein. Polymeric sequence and associated information may be represented using a plurality of data units, each of which includes one or more headers and a payload containing a representation of a segment of the polymeric sequence. Each header may include or be linked to a portion of the associated information. | 04-12-2012 |
20120089340 | ANIMAL IDENTIFICATION, MEASUREMENT, MONITORING AND MANAGEMENT SYSTEM - A highly automated system and method for acquiring animal consumption and behavior data comprising stations where consumables are fed to animals. The stations being equipped with RFID equipment for reading RFID tags in close proximity to the station, and weighing devices for measuring the weight of the consumables. The RFID equipment and the weighing device are connected to a computer which calculates the weight of the trough at specific times by using weight data collected before and after the specified time to enhance the accuracy of the weight measurement. The computer uses a “mathematical weighted filter technique” to estimate the weight of the trough before and after a consumption event. The computer uses a method to divide the reduction/increase in weighed matter between the RFID tag last seen and the next RFID tag appearing, providing the reduction/increase in matter is less than a specified amount. | 04-12-2012 |
20120095691 | HANDHELD DIABETES MANAGEMENT DEVICE HAVING TESTING IN PAIRS BLOOD GLUCOSE TEST - A method for conducting a Testing In Pairs (TIPs) blood glucose (bG) test using a handheld diabetes management device carried by a user. A processing subsystem of the device implements a software module for managing the TIPs test. The software module generates a plurality of predetermined acceptance time windows corresponding to different user defined events. The processing subsystem can identify specific ones of a plurality of bG test values read by the device that are obtained during the predetermined bG acceptance time windows, and which are identified as being related pairs of accepted bG test values that correspond to specific ones of the user defined events. The related pairs of accepted bG test values can then be stored in a database. | 04-19-2012 |
20120095692 | METHOD FOR COMBINING SUB-THERAPEUTIC DOSES - A method is disclosed for selecting ingredient subsets for evaluation. The method receives a selection of at least one primary clinical effect and selects a plurality of ingredients that have the at least one primary clinical effect. In addition, the method scores for each ingredient a strength of the at least one primary clinical effect and each secondary clinical effect for an average therapeutic dose normalized to body mass for each of a group of subjects. The method further selects for evaluation each subset of the plurality of ingredients satisfying the equation | 04-19-2012 |
20120095693 | METHOD AND SYSTEMS FOR PROCESSING POLYMERIC SEQUENCE DATA AND RELATED INFORMATION - Methods and systems for organizing, representing and processing polymeric sequence information, including biopolymeric sequence information such as DNA sequence information and related information are disclosed herein. Polymeric sequence and associated information may be represented using a plurality of data units, each of which includes one or more headers and a payload containing a representation of a segment of the polymeric sequence. Each header may include or be linked to a portion of the associated information. | 04-19-2012 |
20120095694 | METHODS AND SYSTEMS FOR HIGH CONFIDENCE UTILIZATION OF DATASETS - Methods and systems for high-confidence utilization of datasets are disclosed. In one embodiment, the method includes selecting a metric for determining substantially optimal combination of true positives and false positives in a data set, applying an optimization technique, and obtaining, from the results of the optimization technique, a value for at least one optimization parameter, the value for at least one optimization parameter resulting in substantially optimal combination of true positives and false positives. A number of true positives and a number of false positives are a function of the one or more optimization parameters. | 04-19-2012 |
20120095695 | METHODS AND SYSTEMS FOR HIGH CONFIDENCE UTILIZATION OF DATASETS - Methods and systems for high-confidence utilization of datasets are disclosed. In one embodiment, the method includes selecting a metric for determining substantially optimal combination of true positives and false positives in a data set, applying an optimization technique, and obtaining, from the results of the optimization technique, a value for at least one optimization parameter, the value for at least one optimization parameter resulting in substantially optimal combination of true positives and false positives. A number of true positives and a number of false positives are a function of the one or more optimization parameters. | 04-19-2012 |
20120101733 | METHOD AND APPARATUS FOR PROCESSING IMAGE AND MEDICAL IMAGE SYSTEM PERFORMING THE METHOD - An image processing apparatus is provided. The image processing apparatus includes an image mapping unit for generating a mapping image in which first radiation images of multi-energy bands with respect to a local region of a body are mapped to a second radiation image with respect to a thickness variable phantom, an image analyzing unit for analyzing a reference region corresponding to normal tissue in the local region and a peculiar region corresponding to abnormal tissue in the local region based on the mapping image, and an enhancement image generating unit for generating a tissue enhancement image that has a shape of the local region in the first radiation images and enhances regions of pixel positions, that are mapped to the peculiar region, of the first radiation images. | 04-26-2012 |
20120101734 | Method of Predicting Placebo Non-Response - The present invention provides a method of reliably predicting the likelihood of a response to placebo among subjects in, or potentially enrolling in, clinical trials. | 04-26-2012 |
20120101735 | METHOD AND APPARATUS FOR RECOGNIZING AN EMOTION OF AN INDIVIDUAL BASED ON FACIAL ACTION UNITS - An apparatus and method are provided for recognizing an emotion of an individual based on Action Units. The method includes receiving an input AU string including one or more AUs that represents a facial expression of an individual from an AU detector; matching the input AU string with each of a plurality of AU strings, wherein each of the plurality of AU strings includes a set of highly discriminative AUs, each representing an emotion; identifying an AU string from the plurality of AU strings that best matches the input AU string; and outputting an emotion label corresponding to the best matching AU string that indicates the emotion of the individual. | 04-26-2012 |
20120101736 | Method and System for Computing and Integrating Genetic and Environmental Health Risks for a Personal Genome - Methods and systems are provided for the computation and display of an individual's personalized health risk based on the genome sequence of the individual, known etiological interactions between diseases for which the individual is determined to have genetic risk factors, and environmental etiological factors associated with the same diseases that represent potentially modifiable disease risk modifiers. | 04-26-2012 |
20120101737 | BIOSENSING DEVICE - The present invention provides a biosensing device, comprising an input unit, an analysis unit, a process unit, and a set unit for storing resulting data values as the basis for calibrating the biosensing device, to set up the calibration parameters of a strip of the biosensing device. | 04-26-2012 |
20120109529 | SAMPLE PROCESSING APPARATUS AND NON-TRANSITORY STORAGE MEDIUM - A sample processing apparatus includes: a first sample processing unit; a second sample processing unit; and a data processing unit connected to the first and the second sample processing units. The data processing unit includes: a display device; an input device; and a controller configured to show a screen image on the display device, wherein the screen image comprises a shared region which is shared for displaying information of each of the first and the second sample processing units, a first operation section operable by a user to control the first sample processing unit and a second operation section operable by the user to control the second sample processing unit, and control the first sample processing unit in response to an operation of the first operation section, and control the second sample processing unit in response to an operation of the second operation section. | 05-03-2012 |
20120109530 | METHOD OF CLASSIFYING CHEMICALLY CROSSLINKED CELLULAR SAMPLES USING MASS SPECTRA - A method of analyzing cellular samples, particularly gastrointestinal cellular samples, that include a chemically crosslinked analyte is provided. The analysis typically involves the use of mass spectrometry. The methods described herein may be used to identify biomarkers associated with disease as well as to provide risk assessment for developing disease. | 05-03-2012 |
20120109531 | ANALYSIS SYSTEM FOR ANALYZING BIOLOGICAL SAMPLES - An analysis system for analyzing biological samples is disclosed, and which may comprise two or more analysis system components for performing an analysis. A sample workflow manager and an instrument manager coupled to the sample workflow manager may be coupled to the system components for receiving a process status from the system components, wherein the sample workflow manager provides at least one preconfigured processing route to the instrument manager in accordance with the process status. The instrument manager may comprise a memory for storing the preconfigured processing route, wherein the instrument manager is adapted for receiving a test order for analyzing the biological sample using the system components, and wherein the instrument manager is adapted for generating commands for controlling a transport device for transporting the biological sample in accordance with the test order and the at least one preconfigured processing route. | 05-03-2012 |
20120109532 | METHOD AND SYSTEM OF ANALYZING DYNAMIC PHENOMENA - A system and method are provided for measuring dynamic phenomena in a biological, chemical or physical sample, including the measurement of Ca | 05-03-2012 |
20120109533 | METHOD OF ANALYZING PROTEIN USING DATA-INDEPENDENT ANALYSIS COMBINED WITH DATA-DEPENDENT ANALYSIS - The present invention relates to a method of analyzing a protein or proteins comprising the steps of: (A) pre-treating a mixture containing at least one protein to obtain peptides; (B) obtaining information about retention times and mass values of the obtained peptides by performing data-independent analysis; (C) searching a first database on the basis of the information obtained in step (B) to quantify and qualify a target protein or proteins; (D) extracting information about the quantified and qualified target protein or proteins; (E) obtaining information about retention times and mass values by performing data-dependent analysis from the extracted information of step (D); (F) searching a second database on the basis of the information obtained in step (E) to further quantify and qualify the target protein or proteins; and (G) comparing the search results of step (C) and (F) to verify the quantification and qualification. | 05-03-2012 |
20120109534 | AUTOMATIC ANALYZER AND ANALYSIS METHOD - In known automatic analyzers for detecting an abnormality by approximating reaction process data using a function, accuracy of detecting a reaction abnormality is degraded because of poor approximation accuracy depending on test items. Data processing means stores the absorbance and time of day at which the absorbance is measured as time-series data. Letting x denote absorbance, t denote time, and * denote a symbol representing multiplication, we have a function x=a | 05-03-2012 |
20120109535 | Gene Expression Profiles to Predict Relapse of Prostate Cancer - The present disclosure provides a method for cancer relapse prediction that provides higher resolution grading than Gleason score alone. In particular, the method provides for prediction of prostate cancer relapse that correlates gene expression of each individual signature gene and deriving a prostate cancer gene expression (GEX) score in the plurality of prostate cancer tissue samples; and correlating said GEX score with the clinical outcome for each prostate carcinoma tissue sample. A set of signature genes is provided that encompasses all or a sub-combination of GI_2094528, KIP2, NRG1, NBL1, Prostein, CCNE2, CDC6, FBP1, HOXC6, MKI67, MYBL2, PTTG1, RAMP, UBE2C, Wnt5A, MEMD, AZGP1, CCK, MLCK, PPAP2B, and PROK1. | 05-03-2012 |
20120116683 | HIGHLY SELECTIVE CHEMICAL AND BIOLOGICAL SENSORS - Methods and sensors for selective fluid sensing are provided. Each sensor includes a resonant inductor-capacitor-resistor (LCR) sensor that is coated with a sensing material. In order to collect data, an impedance spectrum is acquired over a relatively narrow frequency range, such as the resonant frequency range of the LCR circuit. A multivariate signature may be calculated from the acquired spectrum to discern the presence of certain fluids and/or fluid mixtures. The presence of fluids is detected by measuring the changes in dielectric, dimensional, resistance, charge transfer, and other changes in the properties of the materials employed by observing the changes in the resonant electronic properties of the circuit. By using a mathematical procedure, such as principal components analysis (PCA) and others, multiple fluids and mixtures can be detected in the presence of one another, even in a high humidity environment or an environment wherein one or more fluids has a substantially higher concentration (e.g. 10×, 1,000,000×) compared to other components in the mixture. | 05-10-2012 |
20120116684 | SUPPORTING THE MONITORING OF A PHYSICAL ACTIVITY - Improved techniques and systems for utilizing a portable electronic device to monitor, process, present and manage data captured by a remote sensor during a physical activity session are disclosed. The portable electronic device offers a convenient user interface that can be visual and/or audio based customized to a particular application, user-friendly and/or dynamic. The portable electronic device can pertain to a personal media device and thus also provide media playback. | 05-10-2012 |
20120116685 | Methods, System, And Medium For Associating Rheumatoid Arthritis Subjects With Cardiovascular Disease - The present invention relates to a system and a medium for analyzing one or more analytes in rheumatoid arthritis subjects to determine whether the subject is at increased risk of diseases such as a cardiovascular disease, the subject's current cardiovascular disease burden, and the likelihood of cardiovascular disease progression in the subject. In addition, the present invention further provides methods for analyzing data to determine risk of cardiovascular disease, current cardiovascular disease burden, and the likelihood of cardiovascular disease progression in a rheumatoid arthritis subject. | 05-10-2012 |
20120116686 | Melting Curve Analysis with Exponential Background Subtraction - A method for clustering melting profiles of a plurality of nucleic acid samples, comprising measuring the fluorescence of each nucleic acid sample as a function of temperature to produce a respective raw melting curve for each respective nucleic acid sample, and clustering genotypes of the plurality of nucleic acid samples to form a plurality of clusters of melting curves. A system for analyzing a plurality of nucleic acid samples comprising an instrument for sequentially heating fluorescently detectable complexes while monitoring their fluorescence, a central processing unit (CPU) for performing computer executable instructions, and a memory storage device for storing computer executable instructions that when executed by the CPU cause the CPU to cluster genotypes of a plurality of nucleic acid samples. | 05-10-2012 |
20120123685 | SECONDARY STRUCTURE DEFINING DATABASE AND METHODS FOR DETERMINING IDENTITY AND GEOGRAPHIC ORIGIN OF AN UNKNOWN BIOAGENT THEREBY - The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity. | 05-17-2012 |
20120123686 | HANDHELD DIAGNOSTIC TEST DEVICE AND METHOD FOR USE WITH AN ELECTRONIC DEVICE AND A TEST CARTRIDGE IN A RAPID DIAGNOSTIC TEST - A handheld diagnostic test device includes a port to removably receive a test cartridge, an element connected with an electronic device, and sensors for detection of test data from a biological or environment sample after reaction with reagents onboard the cartridge. The test device also includes memory storing algorithms for upload to the electronic device to enable a processor thereof: to await elapse of a pre-determined time following reaction of the sample with the reagents; to thereafter instruct the sensors to detect the test data; to generate presentation data based on the test data; and to present the presentation data from a presentation element of the electronic device to a user. A related method includes a connecting step, an up-loading step, a presentation step, a cartridge inserting step, a waiting step, a sensing step, and an electronic device processing step. | 05-17-2012 |
20120123687 | ANALYSIS OF DNA SAMPLES - The invention provides an improved method for obtaining information about DNA analysis of samples of uncertain origin by establishing the likelihood that they arose in certain manners compared with other possible manners. In this way all of the analysis information is taken into account and likelihood ratios are provided to express the results. The invention is particularly useful in analysing small DNA samples or DNA samples where the contribution from one or more sources is small. | 05-17-2012 |
20120123688 | RAMAN SPECTROSCOPY FOR BIOPROCESS OPERATIONS - A method of characterizing a multi-component mixture for use in a bioprocess operation that includes providing a multi-component mixture standard with pre-determined amounts of known components; performing a Raman Spectroscopy analysis on the multi-component mixture standard; providing a multi-component test mixture from the bioprocess operation; performing a Raman Spectroscopy analysis on the multi-component test mixture; and comparing the analysis of the multi-component mixture standard and the multi-component test mixture to characterize the multi-component test mixture. In one embodiment, the multi-component mixture standard and the multi-component test mixture both comprise one or more of, at least two, at least three of, or each of, a polysaccharide (e.g. sucrose or mannitol), an amino acid (e.g., L-arginine, L-histidine or L-ornithine), a surfactant (e.g. polysorbate 80) and a pH buffer (e.g., a citrate formulation). | 05-17-2012 |
20120123689 | METHODS AND SYSTEMS FOR DISCRIMINATING BANDS IN SCALOGRAMS - The present disclosure is directed towards embodiments of systems and methods for discriminating (e.g., masking out) scale bands that are determined to be not of interest from a scalogram derived from a continuous wavelet transform of a signal. Techniques for determining whether a scale band is not of interest include, for example, determining whether a scale band's amplitude is being modulated by one or more other bands in the scalogram. Another technique involves determining whether a scale band is located between two other bands and has energy less than that of its neighboring bands. Another technique involves determining whether a scale band is located at about half the scale of another, more dominant (i.e., higher energy) band. | 05-17-2012 |
20120123690 | REAL-TIME SELF-CALIBRATING SENSOR SYSTEM AND METHOD - A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop. | 05-17-2012 |
20120123691 | Method and Device for Early Signal Attenuation Detection Using Blood Glucose Measurements - Methods and devices to detect analyte in body fluid are provided. Embodiments include receiving one or more analyte sensor data, receiving a reference measurement value associated with an analyte level, determining a sensitivity parameter based on the received one or more analyte sensor data and the reference measurement value, performing a probability analysis based on prior analyte sensor data to determine presence of signal attenuation, and generating an output value based on the probability analysis. | 05-17-2012 |
20120123692 | Method And Apparatus For Providing Data Processing And Control In A Medical Communication System - Methods and apparatus for providing data processing and control for use in a medical communication system are provided. | 05-17-2012 |
20120123693 | Device and method for responding to influences of mind - Mental influence detectors and corresponding methods are useful for detecting an influence of mind and hidden or classically non-inferable information. An anomalous effect detector includes a source of non-deterministic random numbers, a converter to convert a property of numbers, a processor to accept converter output and to produce an output signal representative of an influence of mind. The processor output signal contains fewer numbers than the input. A quantum computer includes a physical source of entropy to generate output numbers; a source of test numbers; a measurement processor to accept output numbers and to measure a relationship between process numbers and at least one test number to produce an output representative of an influence of mind. | 05-17-2012 |
20120123694 | Method for Evaluating Renal Function - Plasma concentration of a compound of interest is measured in two or ideally 4 or more blood samples taken from a patient over a period of time following bolus injection. The measured values are input into a computer processor programmed to execute a computer program comprising an algorithm that uses the gamma variate (GV) function to model drug plasma concentration, then uses Tikhonov regularization to perform the fit, selecting a regularization constant so that the relative error in the plasma clearance is minimized. One or more output values representative of renal function are generated. | 05-17-2012 |
20120130645 | METHOD AND APPARATUS FOR MEASURING BODY IMPEDANCE BASED ON BASEBAND SIGNAL DETECTION - Certain aspects of the present disclosure relate to techniques for measuring body impedance based on baseband signal detection in analog domain. Proposed methods and apparatus are able to measure an impedance of human body based on sub-Nyquist sampling of signals. The proposed techniques can be particularly beneficial for reducing overall sensor power when an actuation signal generates electrical signals corresponding to vital signs in humans. | 05-24-2012 |
20120130646 | ANALYTE TESTING METHOD AND SYSTEM WITH HIGH AND LOW ANALYTE TRENDS NOTIFICATION - Described herein are systems and methods to utilize factual information based on stored analyte data to allow greater insight into a chronic disease of a user, such as, for example a diabetic patient. | 05-24-2012 |
20120130647 | SYSTEM AND METHOD FOR IDENTIFYING DISEASE-INFLUENCING GENES - A system and method for using individuals' behavioral and environmental information in conjunction with their gene sequences to find drug candidates and drug targets. Individuals designated as having a high risk for developing a particular disease are each given a remotely programmable apparatus. Queries related to the individuals' behavior and environment are sent from a server to the remotely programmable apparatuses. The individuals' responses to the queries and any physiological information are sent back to the server. The process of collecting individuals' information can take place over a period of time to ensure accurate data and to allow researchers to observe progression of the disease. A data mining program on the server analyzes the individuals' behavioral and environmental information, as well as their gene sequences. | 05-24-2012 |
20120130648 | DETERMINATION OF THE RISK OF DISTANT METASTASES IN SURGICALLY TREATED PATIENTS WITH NON-SMALL CELL LUNG CANCER IN STAGE I-IIIA - A method of determination of the risk of distant metastases in surgically treated patients with non-small cell lung cancer in stage I-IIIA based on that a sample of primary tumor tissue is acquired, from which at least one microRNA is extracted which retrotranscripted into complementary DNA (cDNA) by reverse transcription, wherefore microRNA in examined sample is quantificated with the use of quantitative PCR method while the expression value of each microRNA is referred to the reference expression values in a recurrence prediction model in which the expression values are correlated to the high and low risk of distant metastases is characterized by that the expression value of only one from twenty two microRNAs listed below in Table 1 in primary tumor tissue of non-small cell lung cancer is measured. | 05-24-2012 |
20120136580 | System and Method for Analyzing an Electrophysiological Signal - A system and a method of analyzing an electrophysiological signal, wherein the system comprises an acquisition device for acquiring a test electrophysiological signal associated with an anatomical part of a patient and a processor configured to divide a cycle of the test electrophysiological signal into test time windows, compare a test signal value of each of the test time windows with a reference signal value of reference time windows of the reference segments of respective representations representing respective predetermined morphological classes to obtain a difference, define grid points associated with respective test time windows, respective reference time windows and respective differences, obtain a warping path using the grid points non-linearly in a predetermined order, sum differences along the grid points of each of the warping paths to obtain a cumulative distance for each of the warping paths, and classify the test electrophysiological signal into one of the respective predetermined morphological classes corresponding to the warping path of the respective representation having the least cumulative distance. | 05-31-2012 |
20120136581 | Method of Diagnosing Asphyxia - A method for in vitro diagnosing asphyxia and disorders related thereto, a method of in vitro estimating duration of hypoxia in a patient subjected to asphyxia, and a method for in vitro monitoring of normoxic, hypoxic and hyperoxic conditions and/or normobaric and hyperbaric oxygen therapy, includes quantitatively detecting in a biological sample of a patient a plurality of asphyxia specific endogenous compounds which are selected from the group consisting of biogenic amines; carnitine-derived compounds; amino acids; bile acids; carboxylic acids; eicosanoids; lipids; precursors of cholesterol, cholesterol metabolites; prostanoids; and sugars. | 05-31-2012 |
20120136582 | MEASURING HEMATOCRIT AND ESTIMATING HEMOGLOBIN VALUES WITH A NON-INVASIVE, OPTICAL BLOOD MONITORING SYSTEM - An optical blood monitoring system with a ratiometric model determines hematocrit values for a hemodialysis patient, from which hemoglobin values for the patient are estimated. The ratiometric model is calibrated, normally against a cell counter, using blood from a blood bank. The blood from a blood bank is preserved in a long term preservative which is typically different than that found in clinical settings. The hematocrit value determined by the ratiometric model is scaled by scaling factor so that the estimated hemoglobin level output from the monitor consistently matches that measured in a clinical setting. The hematocrit scaling factor is substantially about 1.033 when the patient's blood sample is stored in a short term preservative ethylene diamine tetra acetic, and is substantially about 1.06 when the hematocrit is measured in the blood sample without preservative being added to the blood sample. The hemoglobin value can also be adjusted for altitude. | 05-31-2012 |
20120136583 | METHOD FOR PREDICTING EFFICACY OF DRUGS IN A PATIENT - The present invention concerns a method for predicting the relative efficacy of a plurality of drugs for treating a tumour in an individual comprising the molecular characterization of the tumour, and the calculation of a score for the plurality of drug essentially based on the percentage of deregulated target gene. | 05-31-2012 |
20120143512 | METHODS OF SELECTION, REPORTING AND ANALYSIS OF GENETIC MARKERS USING BROAD-BASED GENETIC PROFILING APPLICATIONS - Disclosed is a method for determining whether an individual has an enhanced, diminished, or average probability of exhibiting one or more phenotypic attributes and related methods of selecting a set of genetic markers; for providing relevant genetic information to an individual; of evaluating the probability that progeny of two individuals of the opposite sex will exhibit one or more phenotypic attributes; and for determining the genomic ethnicity of an individual. | 06-07-2012 |
20120143513 | BIO-SENSOR CHIP AND READER THEREOF - Provided are a bio sensor chip and a reader thereof. The bio-sensor chip is optically addressed. The bio-sensor chip includes a word line control circuit and a bit line control circuit controlled by light provided from the bio-sensor chip reader. The bio-sensor chip does not require a peripheral circuit for driving word lines and bit lines, simplifying a fabrication process and reducing the area of the chip. | 06-07-2012 |
20120143514 | Movement Monitoring Device For Action Sports, And Associated Methods - A movement monitoring device (MMD) for action sports has a detector for sensing motion associated with action sports, a processor for processing data from the detector to determine one or more movement metrics, and a communications port for wirelessly relaying the movement metrics to a remote location. A method collects motion data within action sports, including: detecting motion of a person or object engaged in action sports; determining one or more events associated with the motion; and wirelessly relaying the events to a remote network. One MMD for action sports is formed within a cell phone having a detector for sensing motion associated with action sports and a processor for processing data from the detector to determine one or more movement metrics for (a) display to a person using carrying the cell phone during action sports or (b) relaying the movement metrics to an external network for review by others. | 06-07-2012 |
20120150448 | Modular Analyte Measurement Systems, Modular Components Thereof and Related Methods - Presented herein is a modular analyte measurement system having a replaceable strip port module that releasably connects and operably couples with an analyte meter. Embodiments of the present invention also relate to modular components of the analyte measurement system. In one aspect, there is provided a replaceable strip port module having a strip port and electrical interface for removably and electrically coupling with an analyte meter. In another aspect, there is provided an analyte meter that includes a processor and electrical interface for removably and electrically coupling with replaceable strip port modules. Methods of configuring the analyte measurement system and methods of determining an analyte meter with the analyte measurement system are also provided. | 06-14-2012 |
20120150449 | Method of Using Human Physiological Responses As Inputs To Hydrocarbon Management Decisions - A method of analyzing hydrocarbon-related data is disclosed. Data representative of a hydrocarbon entity is presented. A physiological response of a viewer of the data is sensed. The physiological response is associated with the data. The data and a representation of the associated physiological response is outputted. | 06-14-2012 |
20120150450 | BIOMETRIC AUTHENTICATION SYSTEM, METHOD, AND PROGRAM - Provided are a biometric authentication system which can guarantee an FMR in a practical processing time even when an attacker attacks the biometric authentication system by selectively using query data in which data of a set other than a biometric information data set is included, a biometric authentication method, and a biometric authentication program. | 06-14-2012 |
20120158311 | APPARATUS FOR REGISTRATION OF TRANSITIONS BETWEEN PSYCHOPHYSIOLOGICAL STATES OF INDIVIDUAL AND METHOD FOR PERFORMING THE SAME - The invention relates to a field of medicine and medical devices. An apparatus for registration of transitions between psychophysiological states of individual comprising a reading unit arranged to be capable of measuring an electromotive force under direct electric current of 0.5 to 5.0 microampere to produce a signal; at least two electrodes connected to reading unit, electrodes arranged to be capable of fixing upon the body of individual; a logarithmic unit, quantization unit comprising a comparator arranged to be capable of determining of whether the difference between the current and the previous signal value is greater than N, where N is a predefined value from 0.1 to 2.0 centineper; and a pulse generator arranged to be capable of generating a pulse having an amplitude of N when the difference between the current and the previous signal value is greater than N; the apparatus further comprising a compensating unit, a processing unit capable of monitoring the pulse values; and at least one power supply. A method for registration of psychophysiological state transition of individual comprises the following steps: (a) measuring of electromotive force between electrodes fixed upon the skin of individual under flow of direct current in interval from 0.5 to 5.0 microampere; (b) logarithming of signal; (c) quantizing the logarithm of signal from step (b) by level from 0.1 to 2.0 centineper; and (d) determining a transition between psychophysiological state of the individual either by registering sudden increase of unidirectional signal pulses amount, or by registering a shift in signal level up to 1.5-3.0 fold as compared to initial value. | 06-21-2012 |
20120166090 | Analyte Monitoring Methods and Systems - A method is disclosed involving monitoring the concentration of at least one target analyte in a sample of body fluid using a meter, the meter including a user interface, the method including: obtaining a sample of body fluid; testing the sample to determine the concentration of the at least one target analyte contained therein; and presenting the user with a reminder to associate the test with an appropriate time corresponding to before or after a particular meal using the user interface. Associated devices, systems and arrangements are also disclosed. | 06-28-2012 |
20120166091 | METHOD AND APPARATUS FOR ANALYZING GAIT PATTERN - A method and apparatus for recognizing a gait pattern are provided. The method for recognizing a gate pattern includes: obtaining a walker's foot pressure distribution values through a pressure sensor array disposed at the bottom of a pair of shoes; calculating valid pressure points among the foot pressure distribution values; calculating a center of pressure (COP) movement trace by using the valid pressure points; and recognizing the walker's gait pattern by using the COP movement trace. | 06-28-2012 |
20120166092 | BLOOD SUGAR VALUE ESTIMATION APPARATUS - The blood sugar value estimation apparatus is configured to non-invasively calculate the blood sugar value with time on the basis of the optical spectrum of the living body measured with time and the calibration model. The apparatus comprises a calibration model creating means configured to create a calibration model from the calibration models or a calibration model from a plurality of the datasets for creating the calibration model. The apparatus is configured to measure a bio-spectrum of a person being tested to set the reference spectrum, and to measure a difference spectrum of a difference between the reference spectrum and a measurement spectrum measured at a time other than a time when the reference spectrum is measured, and to change the calibration model for calculating according to the variation of the difference spectrum. Consequently, the blood sugar value is estimated, especially monitored with time, with high-accuracy. | 06-28-2012 |
20120173151 | METHODS OF ASSESSING DIABETES TREATMENT PROTOCOLS BASED ON PROTOCOL COMPLEXITY LEVELS AND PATIENT PROFICIENCY LEVELS - Embodiments of methods of assessing a diabetes treatment protocol comprise determining a protocol complexity level corresponding to a degree of difficulty of completing the diabetes treatment protocol by utilizing the processor, determining a patient proficiency level corresponding to a skill set of the patient in conducting the diabetes treatment protocol by utilizing the processor, comparing the protocol complexity level to the patient proficiency level via the processor, and providing an output based on the comparison. | 07-05-2012 |
20120173152 | GLUCOSE MANAGEMENT DEVICE AND METHOD OF USING THE SAME - A glucose management device and method of managing glucose using the same. The glucose management device has a housing with an input device and receives a vitro test element that determines a user's glucose level. Glucose measurement circuitry is electrically connected to the vitro test element to communicate data received from the vitro test element to a processor. The processor then prompts a user to input user information regarding units of insulin taken, other medication taken, and activity level into the input device so that the processor records the information for later downloading. | 07-05-2012 |
20120173153 | DATA ANALYSIS OF DNA SEQUENCES - Systems and methods for data analysis are provided. In one embodiment, a method may be provided for analysis comprising electronically receiving sequence data related to a plurality of sequences and a reference sequence, associating the sequence data with one of at least two groups, identifying a plurality of high quality read sequences from among the plurality of sequences, extracting a plurality of unique read sequences from the plurality of high quality read sequences, and aligning the plurality of unique read sequences against the reference sequence data corresponding to a reference sample. The method may further identify mutations in a targeted location, display the targeted mutations, and prioritize the technologies that caused the mutations according to their efficiency. In one example, the systems and methods are used to characterize the activity of several ZFN candidates. | 07-05-2012 |
20120173154 | OXIDATIVE STRESS MEASUREMENT DEVICE AND RELATED METHODS - For measuring an oxidative stress component in a patient, an optical analyzer having a light source and a light detector is used for measuring an optical property of a medium and generating optical measurement data. A processor analyzes the optical measurement data and generates a value for one or more oxidative stress component in the form of a redox signature for the patient. Probability data of the presence of an oxidative stress dependent disease can be calculated. By observing at least one additional clinical condition of the disease, a diagnosis using said at least one additional condition and said redox signature can be obtained. | 07-05-2012 |
20120173155 | NETWORK THREADING APPROACH FOR PREDICTING A PATIENT'S RESPONSE TO HEPATITIS C VIRUS THERAPY - The present invention generally relates to a computer-implemented method for predicting a response of a virus to antiviral therapy, and finds particular use in predicting a response of a Hepatitis C or Hepatitis B virus isolated from a patient. | 07-05-2012 |
20120173156 | METHOD AND SYSTEM FOR CURVE QUALITY CONTROL - A method of analysis wherein molecular interactions at one or more sensing surface areas are detected and respective response curves representing the progress of each interaction with time are produced, and wherein a resulting set of response curves is subjected to a quality assessment procedure which comprises representing the response curves with one or more quality descriptors, applying a quality classification method to the descriptors to find outliers, and removing the outliers. The invention also relates to an analytical system including means for classifying the response curves with regard to quality, a computer program for performing the classification, and a computer program product containing the program. | 07-05-2012 |
20120179380 | MEASUREMENT APPARATUS AND METHOD THEREFOR - A measurement apparatus comprises a probe system ( | 07-12-2012 |
20120179381 | TOXICITY SCREENING METHODS - In vitro methods for predicting in vivo toxicity of chemical compounds, including organ-specific and multiple organ toxicity of such chemical compounds and drug-drug interactions, understanding the relative toxicity of drug candidates and identifying mechanisms of toxicity, are disclosed. | 07-12-2012 |
20120179382 | System for Ventricular Arrhythmia Detection and Characterization - A system for heart performance characterization and abnormality detection detects peaks and at least one of, a valley and a baseline comprising a substantially zero voltage level, of received signal data representing oxygen content of blood in a patient vessel over multiple heart beat cycles. The signal processor determines signal parameters including at least one of, (a) a signal amplitude magnitude between a maximum peak and minimum valley, of the received signal data, (b) a signal amplitude magnitude between a maximum peak and a baseline, of the received signal data and (c) a signal amplitude magnitude between a second highest maximum peak and minimum valley, of the received signal data. The system compares a determined signal parameter or value derived from the determined signal parameter, with a threshold value and generates an alert message associated with the threshold, in response to the comparison. | 07-12-2012 |
20120179383 | DISC AND CALIBRATION METHOD OF TEST DEVICE USING THE SAME - A disc for calibrating a measurement unit of a test device and a calibration method using the same are provided. The disc includes a calibration unit to calibrate a measurement unit of a biomaterial test device. | 07-12-2012 |
20120179384 | METHOD FOR ANALYZING NUCLEIC ACID MUTATION USING ARRAY COMPARATIVE GENOMIC HYBRIDIZATION TECHNIQUE - There is provided a method for analyzing nucleic acid mutation using an array comparative genomic hybridization technique, which reduces the false positive and the false negative and improves the reliability of the analysis results. A method for analyzing nucleic acid mutation using array comparative genomic hybridization technique comprising: [(a) a step of bringing a plurality of labeled sample nucleic acids one by one into contact with the plural same probe nucleic acid sets], [(b) a step of obtaining label intensities], [(c) a step of determining whether each piece of comparison values falls within a prescribed numerical value range or not], and [(d) a step of comparing whether the number of the comparison values exceeds a prescribed number or not and, in the case of exceeding the prescribed number, judging the spot positive]. | 07-12-2012 |
20120179385 | TRAJECTORY CREATING APPARATUS - A trajectory creating unit uses sensor values obtained from an acceleration sensor and an angular velocity sensor that are attached to a predetermined region of a person's body and creates a motion trajectory of the predetermined region. The trajectory creating unit separately creates a motion trajectory of a predetermined region of the person's body obtained between the starting motion of the series of the movements and an impact motion, and a motion trajectory of the predetermined region of the body obtained between the impact motion and the end motion of the movements. | 07-12-2012 |
20120179386 | INTEGRATED SELF-CONTAINED RECORDER OF BIOLOGICAL DATA FOR SMALL ANIMAL RESEARCH - An apparatus and method for the recording of physiological variables in small animals are described. The apparatus is an integrated self-contained recorder including a converter of biological signals into a digital form, a data storage unit, a data output for transporting the stored data from the recorder after the end of recording session, a power source and an electrical connector arranged for connection of the recorder with at least one sensor of biological signal and mechanical fixation of the recorder at the head of an animal. The recorder may contain a sensor, which receives signals from an external source for synchronization of the stored data with external equipment or observed/registered animal behavior. | 07-12-2012 |
20120179387 | Method for Urodynamics Testing and Analysing - A method for urodynamics testing and analysing comprises the steps of building an elastic element model of urethral bladder; building an urethral model; keeping anterior urethra perpendicular to the direction of gravity, measuring and recording urination data and calculating urination parameters; calculating the contraction length of the elastic element, further calculating the contraction velocity and contraction acceleration of the elastic element, and assessing the contraction function of detrusor muscle by using the maximum contraction acceleration of the elastic element; and learning the measurement of urethral resistance by using the cross-section area of the urethral model, and finding out the state of urethral obstruction by using the maximum cross-section area. | 07-12-2012 |
20120185172 | METHOD, SYSTEM AND APPARATUS FOR DATA PROCESSING - A method, system and apparatus for processing requests is provided. The method comprises storing, in a memory, splicing code data comprising a plurality of features, the splicing code data further comprising, in association with each feature, at least one parameter defining the activity of the feature in splicing regulation; receiving a request at a processor, the request identifying at least a first portion of a genomic sequence; receiving, at the processor, at least a second portion of the genomic sequence that is relevant to the first portion; generating, at the processor, a feature set comprising at least one feature from the second portion of the genomic sequence; generating, based on the splicing code data and the feature set, a response to the request, the response comprising at least one of predicted changes in inclusion levels and a predicted feature map for at least one condition; and transmitting the response. | 07-19-2012 |
20120185173 | NEURAL ACTIVITY MEASUREMENT SYSTEM - The present invention provides a neural activity measurement system for measuring the electrical response of a neuron itself to achieve an electrical measurement of the neural activity itself, by providing a stimulator for applying an electrical stimulus to the neuron, as well as a Kelvin probe including a cantilever for detecting the electrical signal propagated through the neuron. | 07-19-2012 |
20120185174 | Prognostic Signature for Colorectal Cancer Recurrance - An assay system is useful for predicting recurrence and/or non-recurrence of colorectal cancer in a patient. The assay system is adapted to analyze a patient sample for quantitative expression of a prognostic genetic profile correlated with colorectal cancer recurrence. The profile includes the expression of the nucleic acid sequences of SEQ ID NOS: 1, 2, 3, 4, and 5. | 07-19-2012 |
20120185175 | NUTRITION FOR A COMPANION ANIMAL - Determining a nutritional diet for a canine or feline companion animal comprises employing a computer; at least one electronic database coupled to the computer; and at least one software routine executing on the computer. First data comprises a relationship between expression data from the genomic map and a physiological condition of the animal, and second data comprises an effect of nutrition on the expression data from the genomic map. Based on said first and second data, a nutritional diet for the canine or feline companion animal is determined. | 07-19-2012 |
20120185176 | Methods for Non-Invasive Prenatal Ploidy Calling - Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus. | 07-19-2012 |
20120191355 | Insect Prediction Techniques for the Forestry Industry - A study of the tip moth-pine tree interaction reveals clues as to the moments when the pine trees are most likely to be damaged by tip moths. From this study, software tools may be extrapolated which help farmers know when to apply pesticides to limit damage to the pine crop and also educational software so student-farmers may know more about the life-cycle of the crop and threats to the crop. While originally focused on the pine tree-tip moth dynamic, the study is readily abstracted for use with other crop-insect dynamics. | 07-26-2012 |
20120191356 | Assembly Error Detection - A method for detecting errors in genetic sequence assemblies including defining an assembly (A) of a sequence of genetic data, collecting read data into a library of reads (L), plotting histograms of sizes or reads versus a number of reads per size, normalizing a distribution (D) with a coverage C to obtain D′ that has a mean (μ) and standard deviation (σ) and reserve positions (i) not used to obtain D′, collecting subset of reads (S | 07-26-2012 |
20120191357 | Discovering Progression and Differentiation Hierarchy From Multidimensional Data - Methods and systems for determining progression and other characteristics of microarray expression levels and similar information, alternatively using a network or communications medium or tangible storage medium or logic processor. | 07-26-2012 |
20120191358 | RISK CALCULATION FOR EVALUATION OF FETAL ANEUPLOIDY - The present invention provides processes for determining accurate risk probabilities for fetal aneuploidies. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples. | 07-26-2012 |
20120191359 | ORGANISM OPTICAL MEASUREMENT DEVICE - An organism optical measurement device having a light transmitter/receiver control unit for obtaining measurement data concerning brain activities and a measurement data display control unit for displaying the measurement data. The organism optical measurement device is further provided with a head surface appearance image acquiring unit for acquiring a head surface appearance image of a subject, a head surface appearance image display control unit for displaying the head surface appearance image, and a measurement-related position calculating unit for calculating the measurement-related position in the head surface appearance image from which the measurement data is obtained when an input device specifies the positions in the head surface appearance image corresponding to the positions of a light transmitting probe and a light receiving probe disposed on the head surface of the subject. The measurement data display control unit displays the measurement data in the measurement-related position in the head surface appearance image. | 07-26-2012 |
20120191360 | CSF biomarker dilution factor corrections by MRI imaging and algorithm - A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated measurements of the ventricular system by MRI scans using quantitative anatomical protocols, determining a measurement of biomarker levels in CSF that has been extracted, correcting the measurement of the level of said at least one biomarker'according to the ventricular size, and providing a corrected result of the measurement determined in step (b), said corrected result accounting for concentration dilution due to the change in ventricular size. The method is particularly suited for the measurement of all biomarkers found in the CSF, such as those associated with mild cognitive impairment (MCI) and Alzheimer's Disease. | 07-26-2012 |
20120191361 | Tracking the Probability for Imminent Hypoglycemia in Diabetes From Self-Monitoring Blood Glucose (SMBG) Data - A method, system and related computer program product for tracking the probability of hypoglycemia from routine self-monitoring of blood glucose (SMBG) data in patients with diabetes. A specific bivariate probability distribution of low BG events based jointly on the Low BG Index (LBGI) and the Average Daily Risk Range (ADRR) is used to predict hypoglycemia probability of occurrence from inputted SMBG data. The SMBG data is retrieved from a series of SMBG data of a patient available from the patient's glucose meter and allows tracking of the probability for future hypoglycemia over a predetermined duration, e.g., a | 07-26-2012 |
20120191362 | CALIBRATION METHOD FOR THE PROSPECTIVE CALIBRATION OF MEASURING EQUIPMENT - A method for operating measuring equipment for detecting an analyte in a bodily fluid by means of a continuously measuring blood glucose sensor. A calibration method is carried out for the prospective calibration of the measuring equipment. At least three calibration points are detected in the calibration method, wherein each calibration point comprises a measurement signal from the measuring equipment and a reference value of an associated reference measurement. A plurality of possible slopes are established between the calibration points. At least one robust estimation method, using a formation of at least one median is used to determine a probable slope from the plurality of possible slopes. Furthermore, a measurement is carried out. During the measurement and using the probable slope, a concentration of the analyte in the bodily fluid is deduced from a measurement signal from the measuring equipment and the probable slope. | 07-26-2012 |
20120191363 | Reagents, Methods, and Libraries for Bead-Based Sequencing - The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension probes containing phosphorothiolate linkages and employ agents appropriate to cleave such linkages. The invention provides methods of determining information about a sequence using at least two distinguishably labeled probe families. In certain embodiments the methods acquire less than 2 bits of information from each of a plurality of nucleotides in the template in each cycle. In certain embodiments the sequencing reactions are performed on templates attached to immobilized beads. The invention further provides sets of labeled extension probes containing phosphorothiolate linkages. In addition, the invention includes performing multiple sequencing reactions on a single template by removing initializing oligonucleotides and extended strands and performing subsequent reactions using different initializing oligonucleotides. | 07-26-2012 |
20120191364 | METHODS AND ARRAYS FOR DNA SEQUENCING - A method of sequencing a first polynucleotide strand having a first polynucleotide sequence, the first polynucleotide strand resembling a second polynucleotide strand having a known second polynucleotide sequence, the method employing a data set which, for one or more fragment(s) of the second polynucleotide sequence, contains: for each position along each said fragment: (i) first probe data describing the hybridization intensity of the first polynucleotide strand with a respective first probe designed to bind to a portion of the second polynucleotide strand centered at said position; and (ii) second probe data describing the respective hybridization intensities of the first polynucleotide strand with each of a set of second probes, each said second probe being designed to bind with a respective mutation of the corresponding portion of the second polynucleotide sequence which is formed by mutating the corresponding portion of the second polynucleotide sequence at said position, the data set including said second probe data for every possible said mutation; the method comprising: for each said position, obtaining from the dataset a first numerical parameter characterizing the hybridization intensity of the first polynucleotide strand with the corresponding first probe in comparison to the hybridization intensities of the first polynucleotide strand with the corresponding second probes; said first numerical parameter being indicative of whether a nucleic acid of the first polynucleotide sequence is equal to a nucleic acid the second polynucleotide sequence at said position. | 07-26-2012 |
20120191365 | AUXILIARY DIAGNOSTIC APPARATUS AND AUXILIARY DIAGNOSTIC METHOD - Disclosed is an auxiliary diagnostic apparatus including: a vector input unit that reads a test vector which is a spectral property vector of a biological tissue targeted for a diagnosis; a multiple linear regression analysis unit that executes a multiple liner regression analysis for the test vector with a plurality of individual component vectors which are spectral property vectors of particular substances, and obtains an error vector which is a vector of a residual error component; and an indicator calculation unit that extracts a feature of the error vector, and, from the extracted error vector, calculates an indicator representing whether an affected area is included in the biological tissue targeted for the diagnosis and which type of affected area has a possibility of being included in the biological tissue. | 07-26-2012 |
20120197533 | IDENTIFYING REARRANGEMENTS IN A SEQUENCED GENOME - Methods, apparatuses, and systems for identification of junctions (e.g., resulting from large-scale rearrangements) of a sequenced genome with respect to a human genome reference sequence is provided. For example, false positives can be distinguished from actual junctions. Such false positives can result from many sources, including mismapping, chimeric reactions among the DNA of a sample, and problems with the reference genome. As part of the filtering processes, a base pair resolution (or near base pair resolution) of a junction can be provided. In various implementations, junctions can be identified using discordant mate pairs and/or using a statistical analysis of the length distributions of fragments for local regions of the sample genome. Clinically significant junctions can also be identified so that further analysis can be focused on genomic regions that may have more of an impact on the health of a patient. | 08-02-2012 |
20120197534 | BIOMARKER MONITORING DEVICE AND METHOD - A biomarker monitoring method and system in one embodiment includes a communications network, a portable wellness device configured to form a communication link with the communications network, the portable wellness device including a detector configured to detect at least one biomarker in a biologic sample, a first memory, a plurality of program instructions stored in the first memory, and a processing circuit operably connected to the first memory and configured to execute the program instructions to generate wellness data based upon detection of the at least one biomarker in the biologic sample, and a remote user interface operably connected to the communications network and configured to render the wellness data. | 08-02-2012 |
20120197535 | Methods for identifying bacteria - The present invention provides methods for identifying bacteria by analysis of lipid A and/or lipoteichoic acid structure and/or mass spectrometry ionization patterns. | 08-02-2012 |
20120197536 | METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR CALCULATING DAILY WEIGHTED AVERAGES OF GLUCOSE MEASUREMENTS (OR DERIVED QUANTITIES) WITH TIME-BASED WEIGHTS - A method and system for calculating daily weighted averages of glucose measurements (or derived quantities) with time-based weights are disclosed. The present invention computes an average daily glucose value using the time based weights based on only consecutive glucose measurements in the plurality of glucose measurements with acceptable time intervals that do not exceed a predefined maximum time interval. The invention further relates to a computer program for implementing the method for calculating daily weighted averages of spot monitoring glucose measurements (or derived quantities) with the time-based weights. | 08-02-2012 |
20120197537 | DETERMINATION OF MELTING TEMPERATURES OF DNA - Numerical determinations of the first derivatives of a melt curve data set are made. A model function, such as a Gaussian Mixture Model (GMM) function, with parameters determined using a Levenberg-Marquardt (LM) regression process is used to find an approximation to the first derivative curve. The maximum values of the numerically determined first derivative values are used as initial conditions for parameters of the model function. The determined parameters provide one or more fractional melting temperature values, which can be returned, for example, displayed or otherwise used for further processing. | 08-02-2012 |
20120197538 | AUTOMATED CLINICAL SYSTEM TO FACILITATE SECONDARY REVIEW AND AUTHENTICATION OF CLINICAL LABORATORY RESULT VALUES - A method in a computer system for the review and authentication of clinical laboratory result values is provided. The method includes receiving patient data. The method also includes accessing review criteria. The method further includes comparing the patient data and the review criteria to determine if the patient data should be routed for review. The method further includes routing qualified patient data to a review hierarchy including at least one review queue defined by at least one user. | 08-02-2012 |
20120197539 | METHODS FOR DIAGNOSIS, TREATMENT AND MONITORING OF PATIENT HEALTH USING METABOLOMICS - A method for assessing patient health is provided using metabolomics. The method comprises providing a bodily fluid or tissue sample from a subject, collecting a metabolic profile from the bodily fluid or tissue sample and comparing the metabolic profile to a reference profile, wherein the preferred bodily fluid is urine. Reference profiles are also provided. | 08-02-2012 |
20120203464 | NORMALIZED CONTEXTUAL PERFORMANCE METRIC FOR THE ASSESSMENT OF FATIGUE-RELATED INCIDENTS - A normalized contextual performance metric quantifies the susceptibility of fatigue-related risk in a fatigue environment with activities conducted within a fatigue level range of interest. Fatigue incidents are quantified by one of a plurality of values associated with fatigue-incident measurement. Activities are quantified by one of a plurality of values associated with activity measurement. A normalized contextual performance metric is determined by identifying a fatigue level range of interest, summing all values of incidents occurring at the fatigue level range of interest, summing all values for relevant activities occurring at the fatigue level range of interest, and then dividing the first sum by the second. The normalized contextual performance metric thereby allows operational managers to assess risk of fatigue incidents by monitoring activities and fatigue levels within the fatigue environment. | 08-09-2012 |
20120203465 | SYSTEMS, METHODS AND PROGRAM PRODUCTS FOR COLLECTING AND ORGANIZING HEALTH DATA - One example embodiment of the invention is a system for collecting, measuring and outputting health data including a plurality of readers that each determine a plurality of different biomarker measurements from a bodily fluid sample, the test readers communicating test data sets over a network. A central computer is linked to each of the plurality of test readers and receives the test data set, the central computer associates at least a first security key with the test data set. The central computer responds to a first request for a test output report that includes the first security key and retrieves the corresponding test data set. The central computer prepares a test output report that includes a plurality of bodily fluid test measurements and transmits it over a network. | 08-09-2012 |
20120203466 | SYSTEM AND METHOD FOR IDENTIFYING DISEASE-INFLUENCING GENES - A system and method for using individuals' behavioral and environmental information in conjunction with their gene sequences to find drug candidates and drug targets. Individuals designated as having a high risk for developing a particular disease are each given a remotely programmable apparatus. Queries related to the individuals' behavior and environment are sent from a server to the remotely programmable apparatuses. The individuals' responses to the queries and any physiological information are sent back to the server. The process of collecting individuals' information can take place over a period of time to ensure accurate data and to allow researchers to observe progression of the disease. A data mining program on the server analyzes the individuals' behavioral and environmental information, as well as their gene sequences. | 08-09-2012 |
20120203467 | SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and/or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred. | 08-09-2012 |
20120203468 | SAMPLE PROCESSING APPARATUS, METHOD OF OUTPUTTING PROCESSING RESULT BY SAMPLE PROCESSING APPARATUS, AND COMPUTER PROGRAM PRODUCT - Disclosed is a sample processing apparatus, comprising: a sample processing unit for processing a sample with an auxiliary item used to process the sample; an output device for outputting a processing result by the sample processing unit; and a controller for determining whether or not the auxiliary item is appropriate for the sample processing by sample processing unit, and controlling, when determining that the auxiliary item is not appropriate for the sample processing by the sample processing unit, the output device so as to output the processing result and reliability information showing that the processing result has a low reliability. Also disclosed is a method for outputting the processing result by the sample processing apparatus and a computer program product. | 08-09-2012 |
20120203469 | METHOD OF EVALUATING TOXICITY LEVEL OF A PATIENT UNDERGOING A CANCER TREATMENT - This invention relates to a method and a system of evaluating toxicity level of a patient undergoing a cancer treatment protocol. Patient's related data including biomarkers of toxicity level caused by said cancer treatment are received. These biomarkers of toxicity level are then compared with a range of reference biomarkers of toxicity level caused during a similar cancer treatment. Finally, an alert signal is issued in case the biomarkers of toxicity level fall outside said range of reference biomarkers of toxicity level. | 08-09-2012 |
20120209532 | PORTABLE EVALUATOR OF AMOUNT OF EXERCISE AND THE METHOD OF EVALUATING AMOUNT OF EXERCISE - A portable evaluator of amount of exercise detects an acceleration and angular speed of the user. After using an exercise identifying procedure to identify the exercise type, the portable evaluator finds a corresponding strength formula to evaluate the amount of exercise done by the user. The result is displayed for reference. By detecting the acceleration and angular speed, the portable evaluator identifies exercise types that involve rotations. Different formulas are used for different kinds of exercise. | 08-16-2012 |
20120209533 | ACTIVITY MONITOR, METHOD OF CALCULATING TARGET ACTIVITY AMOUNT, AND STORAGE MEDIUM - The activity monitor ( | 08-16-2012 |
20120209534 | METHOD AND SYSTEM FOR ANALYZING LIQUID - A method of analyzing liquid is disclosed. The method comprises: obtaining data pertaining to a dripping pattern characterizing formation of liquid drops as a function of the time, and comparing the dripping pattern to a reference dripping pattern. | 08-16-2012 |
20120209535 | METHOD FOR GENERATING BIOMARKER REFERENCE PATTERNS - The present invention relates to methods for evaluating biomarkers. In particular, the invention relates to a method for establishing at least one pattern for at least one pre-defined effector having at least one effect on a biological system, which effect is capable of being determined, to a method of establishing a class of effectors for a pre-defined effect or group of effects, to a method for identifying at least one effect of a pre-defined effector and to a computer program and a computer adapted to carry out these methods. | 08-16-2012 |
20120215454 | Adaptive lightweight acoustic signal classification for physiological monitoring - The present invention provides adaptive lightweight acoustic signal classification for physiological monitoring applications. In an exemplary implementation, the total energy of a segment of an acoustic signal recording body sounds is first determined. For each of a plurality of signal classes (e.g., good, noisy, weak), the probability that the segment belongs to the signal class is then calculated using the total energy and profile data for the signal class. The segment is then assigned to one of the plurality of signal classes by reference to the probabilities. Physiological data are then selectively generated and outputted using the segment, depending on the assigned signal class, and the segment is selectively applied as feedback to update profile data for the assigned signal class. | 08-23-2012 |
20120215455 | System and Method for Medical Diagnosis Using Geospatial Location Data Integrated with Biomedical Sensor Information - In at least one embodiment, a method and system for accumulating geospatial location data and biomedical data for an individual during his/her travels is provided. In at least one embodiment, a device uses at least one location signal to determine geospatial data and receives a plurality of biomedical signals with both data types being stored for possible later retrieval for providing a diagnosis for the individual if a medical condition arises. An embodiment of the invention provides a method of operation of a device having at least a memory and a communications module where the method includes receiving at least one location signal with the communications module; storing geospatial data obtained at least from the at least one location signal with a time stamp in memory; receiving a plurality of biomedical signals over time from at least one sensor with the communications module; storing biomedical data from the received biomedical signal with a time stamp in memory; and repeating the receiving at least one location signal and storing geospatial data from the at least one location signal in different geographic locations. | 08-23-2012 |
20120215456 | SYSTEM AND METHOD FOR CELLULAR OPTICAL WAVEFRONT SENSING - An optical system for non-invasive cytometry of mammalian cells includes a light source, a cell positioner, an optical imager, an optical wavefront sensor and a computer. The light source produces an illuminating beam of spatially coherent radiation. The cell positioner sequentially moves a single cell from a population of multiple cells into a sub-aperture region of the illumination beam whose wavefront is perturbed in response to the physical structure of the single cell. An optical system relays a magnified image of the sub-aperture region containing the cell to an image plane. At the image plane a Shack-Hartmann wavefront sensor is positioned. Within the pupil of the wavefront sensor the local tilts of the wavefront in the sub-aperture region are measured and sent to a computer. Software calculates the Zernike coefficients corresponding to the aberration induced by the structure of each cell. Their Zernike signatures classify the cells into distinct types. | 08-23-2012 |
20120215457 | METHODS AND SYSTEMS TO ANALYZE REACTIONS USING AN INFORMATION SYSTEM - Disclosed are example methods and systems to determine the quantity of an analyte initially present in a chemical and or biological reaction. Also disclosed are computer implemented methods and systems to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction. | 08-23-2012 |
20120215458 | Orthologous Phenotypes and Non-Obvious Human Disease Models - A method for the quantification of equivalence between mutational phenotypes to develop non-obvious human disease models is described herein. The present inventors discover candidate genes for diseases of interest by: first, identifying orthologous phenotypes (called phenologs) involving the phenotype of interest (the first phenotype), in which a set of genes is associated with the first phenotype in the first organism, a set of genes is associated with a second phenotype in a second organism, the first and second phenotypes not having one or more common characteristics, and the second phenotype is selected such that at least one gene belongs to both the first and second phenotype gene sets; second, selecting from the second organism one or more second phenotype genes, other than the genes known to overlap the first and second phenotypes, as candidates for also belonging to the first phenotype in the first organism. | 08-23-2012 |
20120215459 | HIGH THROUGHPUT DETECTION OF GENOMIC COPY NUMBER VARIATIONS - The invention relates to methods and algorithms for detecting and analysis of copy number variances in a genetic segment. The invention also relates to a computer implemented sequential method of processing and interpreting experimental data generated by genotyping nucleic acid-chips or nucleic acid-beads based on detection of a hybridization signal. | 08-23-2012 |
20120215460 | Temperature-Adjusted Analyte Determination For Biosensor Systems - A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature. | 08-23-2012 |
20120215461 | SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA - Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor. | 08-23-2012 |
20120215462 | SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA - Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor. | 08-23-2012 |
20120221249 | Long Hepitype Distribution (LHD) - The invention includes a method of creating a sequence information framework that defines the range of epigenetic configurations of individual DNA strands in any diploid organism in which DNA methylation is prevalent. The invention also includes a method of generating DNA descriptors referred to as long hepitype distributions (LHDs). | 08-30-2012 |
20120221250 | SYSTEM AND METHOD FOR MONITORING THE FEEDING PRACTICES OF INDIVIDUAL ANIMALS IN A GRAZING ENVIRONMENT - There is disclosed a method for the management of animals grazing in a pasture, comprising feeding a marker labelled supplement to grazing animals. Monitoring consumption of said marker labelled supplement by said animals to generate supplement consumption data for said animals. Measuring physical characteristics of said animals to generate physical characteristic data for said animals. Collecting faecal samples from said animals. Analysing said faecal samples, samples of said pasture and said supplement to generate faecal data, pasture data and supplement data and processing Said supplement consumption data, said physical characteristic data and said fecal data, pasture data and supplement data to determine individual animal diet and nutritional information for animal management purposes. | 08-30-2012 |
20120221251 | SYSTEMS AND METHODS FOR SELECTING, ORDERING, SCHEDULING, ADMINISTERING, STORING, INTERPRETING AND TRANSMITTING A PLURALITY OF PSYCHOLOGICAL, NEUROBEHAVIORAL AND NEUROBIOLOGICAL TESTS - A system comprises a validation module and an analysis module. The validation module is configured to receive input data from an electronic device operated by a test-taker during a biopsychosocial assessment. The input data includes a plurality of input terms that describes a functioning of the test-taker. The validation module is configured to validate the plurality of input terms based on a plurality of pre-defined terms stored within the system. The analysis module is configured to generate a list of potential biopsychosocial-related issues associated with the test-taker based on the validated input terms, and to generate a recommendation of one or more tests to administer to the test-taker based on this list. The analysis module is further configured to transmit an output signal representing the recommendation to an electronic device such that the one or more recommended tests are presented at an electronic device. | 08-30-2012 |
20120221252 | SYSTEMS AND METHODS FOR DISTINGUISHING OPTICAL SIGNALS OF DIFFERENT MODULATION FREQUENCIES IN AN OPTICAL SIGNAL DETECTOR - Systems and method for detecting optical signals, and for discriminating optical signals emitted by an emission moiety that is excited by an associated excitation signal from background signals and other optical noise, employing digital techniques for determining the portion of a detected optical signal having a modulation frequency corresponding to a modulation of the associated excitation signal. | 08-30-2012 |
20120221253 | DEVICES AND METHODS FOR MONITORING, MANAGING, AND SERVICING MEDICAL DEVICES - A method and apparatus for billing entities for use of a medical device, which relates to the processing of regenerative cells to facilitate at least one of hard and soft tissue formation, are described. When an operator uses the medical device, a corresponding charge is determined. Billing for usage of the medical device is performed on a periodic or per-use basis. Communication over a network facilitates remote management and servicing of the medical device. Support is provided for automatic ordering of supplies consumed by the medical device. | 08-30-2012 |
20120221254 | DATA COLLECTION UNIT WITH INTEGRATED CLOSURE SYSTEM AND SENSOR HOUSING - A physical activity data collection unit includes one or more infrared sensors configured to provide an output indicative of a pulse rate of a user of the physical activity data collection unit, at least one temperature sensor configured to provide an output indicative of at least a body temperature of the user, and at least one accelerometer configured to provide an output indicative of movements of the user. The physical activity data collection unit can also include a microcontroller configured to determine a pulse rate, a body temperature, and movement characteristics of the user of the data collection unit based on outputs from the one or more infrared sensors, the at least one temperature sensor, and the at least one accelerometer; determine a physical exertion level of the user based on one or more of the pulse rate, the body temperature, or the movement characteristics of the user; and store, in a memory, data indicative of the physical exertion level during a time period during which the physical exertion level exceeds a predetermined threshold. The physical activity data collection unit can also include a closure system configured to secure the data collection unit to a wrist of the user. | 08-30-2012 |
20120226444 | Ventilator-Initiated Prompt Regarding High Delivered Tidal Volume - This disclosure describes systems and methods for monitoring and evaluating ventilatory data to provide useful notifications and/or recommendations. Indeed, many clinicians may not easily identify or recognize data patterns and correlations indicative of certain patient conditions or the effectiveness of ventilatory treatment. Further, clinicians may not readily determine appropriate adjustments that may address certain patient conditions or the effectiveness of ventilatory treatment. Specifically, clinicians may not readily detect or recognize the occurrence of high-delivered V | 09-06-2012 |
20120232801 | METHOD AND SYSTEM FOR EVALUATING FEEDING PERFORMANCE OF INDIVIDUAL NEONATES - A method and system for computing a relative score indicative of an individual infant's feeding performance based, at least in part, upon a comparison of one or more feeding factor measurements of the individual infant with a corresponding database metric that is derived from a population-based sample of infants, where the comparison optionally provides a statistical association between normative metric values and adverse outcomes recorded for the same population-based sample and, thereby, a means for assessing the tested infant's risk for said adverse outcomes. | 09-13-2012 |
20120232802 | DETERMINING A PLANE OF AN ANATOMICAL BODY PART - A data processing method for determining the position of a main plane of an anatomical body part, comprising the steps of: ·providing absolute auxiliary point data which describe the position of at least one actual auxiliary point of the body part relative to a marker device attached to the body part, the at least one actual auxiliary point being outside the main plane; ·providing relative point data which constrain the possible positions of the main plane relative to the at least one actual auxiliary point; ·providing absolute main point data which describe the position of one or two actual main points of the body part relative to the marker device attached to the body part, said one or two actual main points lying in the main plane and/or calculating the position of at least one virtual main point relative to the marker device, said at least one virtual main point being in the main plane and being calculated based on the absolute auxiliary point data and the relative point data; ·calculating a position of the main plane relative to the marker device, wherein the calculation uses the relative point data and auxiliary point data as well as the provided absolute main point data and/or the calculated position of the at least one virtual main point. | 09-13-2012 |
20120232803 | CHARACTERIZATION OF BLOOD HEMOSTASIS AND OXYGEN TRANSPORT PARAMETERS - An integrated system for determining a hemostasis and oxygen transport parameter of a blood sample, such as blood, is disclosed. The system includes a measurement system, such as an ultrasonic sensor, configured to determine data characterizing the blood sample. For example, the data could be displacement of the blood sample in response to ultrasonic pulses. An integrated aspect of the system may be a common sensor, sample portion or data for fast and efficient determination of both parameters. The parameters can also be used to correct or improve measured parameters. For example, physiological adjustments may be applied to the hemostatic parameters using a HCT measurement. Also, physical adjustments may be applied, such as through calibration using a speed or attenuation of the sound pulse through or by the blood sample. These parameters may be displayed on a GUI to guide treatment. | 09-13-2012 |
20120232804 | SYSTEM AND METHOD FOR PARAMETER ESTIMATION IN BIOLOGICAL PROCESSES - A method of measuring a biological process, the method including the steps of: (a) determining a probability density function for a series of repeated measurements of the biological process; (b) approximating the probability density function utilising a parametric formula; (c) determining a maximum likelihood estimator for the parametric formulation of the probability density function; and (d) utilising the maximum likelihood estimator for subsequent measurements of the biological process. | 09-13-2012 |
20120239303 | System and Method for Health Monitoring Using Real-Time Location - In certain embodiments, a method includes storing location information associated with a dairy livestock. The stored location information includes a location of the dairy livestock within a free stall pen at each of a plurality of times during a time period. The method further includes determining, based on at least a portion of the stored location information, one or more movement parameters associated with the dairy livestock. The method further includes determining, based on the one or more movement parameters associated with the dairy livestock, whether the dairy livestock is likely unhealthy. | 09-20-2012 |
20120239304 | Method and System for Determining Analyte Levels - Methods and apparatus for analyte level estimation are provided. | 09-20-2012 |
20120239305 | HIGH-RESOLUTION MELTING ANALYSIS - The application relates to methods and systems for analysis of dissociation behavior of nucleic acids and identification of nucleic acids. In one aspect, methods and systems are disclosed for identifying a nucleic acid in a sample including an unknown nucleic acid and for detecting a single nucleotide polymorphism in a nucleic acid in a sample. Methods and systems are also disclosed for identification of a nucleic acid in a biological sample including at least one unknown nucleic acid by fitting denaturation data including measurements of a quantifiable physical change of the sample at a plurality of independent sample property points to a function to determine an intrinsic physical value and to obtain an estimated physical change function, and identifying the nucleic acid in the biological sample by comparing the intrinsic physical value for at least one unknown nucleic acid to an intrinsic physical value for a known nucleic acid. | 09-20-2012 |
20120245852 | APPARATUS FOR CALCULATING SCORES FOR CHAINS OF SEQUENCE ALIGNMENTS - Each of a plurality of substantially co-linear alignments has a score. Each alignment may comprise a starting alignment that has been diagonally extended to meet a length requirement. Dynamic programming is performed in interalignment regions between the extended alignments to generate a corresponding set of interalignment scores. Alignment scores and interalignment scores are summed to generate a score for the entire chain of alignments. This process is repeated for multiple chains. Chains of alignments are ranked by chain score and are displayed to a user. In one embodiment, additional dynamic programming is performed at the head and tail of each chain to increase the chain score when possible. An integrated circuit that performs the method at high speed in hardware is disclosed. Techniques are disclosed that reduce the amount of interalignment dynamic programming. The method increases sensitivity and gives an order of magnitude speed improvement over NCBI-BLAST. | 09-27-2012 |
20120245853 | Device For Adaptive Processing Of An Endocardial Acceleration Signal - Device for adaptive processing of an endocardial acceleration signal. The device continuously collects an endocardial acceleration EA signal and divides it into EA sub-signals, each over the duration of one cardiac cycle. The EA sub-signals are separated into the EA | 09-27-2012 |
20120245854 | METHOD OF DIAGNOSING, PROGNOSING AND MONITORING ALZHEIMER'S DISEASE - The present invention provides a system and method for diagnosing, monitoring or prognosing Alzheimer's disease using at least one sensor comprising carbon nanotubes coated with cyclodextrin or derivatives thereof and/or at least one sensor comprising metal nanoparticles coated with various organic coatings in conjunction with a learning and pattern recognition algorithm. | 09-27-2012 |
20120245855 | SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and/or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred. | 09-27-2012 |
20120245856 | CHARACTERIZATION OF MOLECULES - The invention involves obtaining signatures of species (including chemical, biological, or biochemical molecules) and/or signatures of interactions between species and using them to characterize species, characterize interactions, and/or identify species that could be useful in a variety of settings. Signatures can be obtained using aqueous multi-phase partitioning and can be used to predict molecular interactions for applications such as drug discovery. A plurality of aqueous multi-phase partitioning arrangements can define an overall system providing an information-intensive signature, maximizing precision and sensitivity. | 09-27-2012 |
20120253684 | METHODS AND APPARATUS FOR PERFORMING RETENTION-TIME MATCHING - A method for matching a precursor ion with one or more related product ions includes providing input data sets obtained from sample injections, each of the data sets including a precursor ion and one or more product ions, normalizing the input data sets in accordance with a single retention time for the precursor ion, determining which product ions are within a predetermined retention time window with respect to the single retention time, and, if a product ion is within the predetermined retention time window for a specified number of the input data sets, determining that the product ion is related to the precursor having the single retention time. An apparatus for analyzing a sample includes a chromatography module, a mass-spectrometry module in communication with the chromatography module, and control unit in communication with the chromatography module and the mass-spectrometry module. | 10-04-2012 |
20120253685 | TESTING PROCESS - A method of determining an inclusive residual risk that a pregnancy is affected by at least one phenotypic disorder included in a disorder set is provided. The method includes calculating a prior risk for a disorder set, calculating posterior risks for the individual disorders or groups of disorders in the disorder set that can be screened for and/or diagnosed prenatally, and calculating an inclusive residual risk for the disorder set by combining the prior risks for disorders for which no tests have been performed and the individual posterior risks. | 10-04-2012 |
20120253686 | SYSTEM AND METHOD FOR MULTIPLE-FACTOR SELECTION - The disclosed subject matter provides techniques for multiple-factor selection. The factors can be features or elements that are jointly associated with one or more outcomes by their joint presence or absence. There may be a non-causative correlation between the factors, features, or elements and the outcomes. In some embodiments, Entropy Minimization and Boolean Parsimony (EMBP) is used to identify modules of genes jointly associated with disease from gene expression data, and a logic function is provided to connect the combined expression levels in each gene module with the presence of disease. The smallest module of genes whose joint expression levels can predict the presence of disease can be identified. | 10-04-2012 |
20120253687 | METHOD FOR ANALYZING RNA - A method of analyzing RNA extracted from a tissue or cell(s) fixed with a fixative, said method comprising a determining step of whether said RNA satisfies: B/A≦1 wherein A represents the weight ratio (%) of RNA within the range of 1000 to 4000 nucleotides with respect to the total weight of RNA as determined by electrophoresis; and B represents the weight ratio (%) of RNA within the range of more than 4000 nucleotides with respect to the total weight of RNA as determined by electrophoresis. | 10-04-2012 |
20120253688 | System, Method, and Computer Product for Exon Array Analysis - In one embodiment, a method for analyzing data generated by probe arrays is described that comprises receiving user selections of two or more data files and an identification of one or more subsets of intensity values acquired from a biological probe array. The method includes iteratively opening each data file, identifying the selected subset of intensity values associated with each open data file, determining parameters for processing, storing the parameters and the identified intensity values, and closing the open data file prior to the subsequent iteration. The method then includes processing the stored intensity values using the parameters to identify one or more biological events. | 10-04-2012 |
20120259554 | TONGUE TRACKING INTERFACE APPARATUS AND METHOD FOR CONTROLLING A COMPUTER PROGRAM - A tongue tracking interface apparatus for control of a computer program may include a mouthpiece configured to be worn over one or more teeth of a user of the computer program. The mouthpiece can include one or more sensors configured to determine one or more tongue orientation characteristics of the user. Other sensors such as microphones, pressure sensors, etc. located around the head, face, and neck, can also be used for determining tongue orientation characteristics. | 10-11-2012 |
20120259555 | Dynamic and Differential Analysis - The present invention provides methods to improve upon prostate cancer screening, thereby saving lives and reducing morbidities of unwarranted biopsies and over-treatment. The methods use a systematic analysis of the growth rate of PSA from cancer and PSA variation and the way in which they might be used to distinguish high-risk cancers from no cancer. Approaches include Dynamic-Differential Strategy, Dynamic-Differential Analysis, and Dynamic Analysis. | 10-11-2012 |
20120265446 | BIOMARKERS BASED ON SETS OF MOLECULAR SIGNATURES | 10-18-2012 |
20120265447 | METHOD FOR COMBINING INDIVIDUAL RISK VARIABLES DERIVED FROM CARDIOPULMONARY EXERCISE TESTING INTO A SINGLE VARIABLE - A method of pattern recognition for classifying the functional status of patients with chronic disease comprising characterizing the functional status based on a multivariable index (MVI) scoring system wherein the MVI is computed by summing a plurality of individual variable values as individual variable indexes (IVI) and dividing the sum by the number of variables and wherein the plurality of IVI includes rest PetCO | 10-18-2012 |
20120271553 | ANALYZING THE EXPRESSION OF BIOMARKERS IN CELLS WITH CLUSTERS - A data set of cell profile data is stored. The cell profile data includes multiplexed biometric image data describing the expression of a plurality of biomarkers. Cell profile data is generated from tissue samples drawn from a cohort of patients having an assessment related to the commonality. Multiple sets of clusters of similar cells are generated from the data set; the proportion of cells in each cluster is examined for an association with a diagnosis, a prognosis, or a response; and a predictive set of clusters is selected based on model performance. One predictive set of clusters is selected based on a comparison of the performance of at least one model of the plurality of sets of clusters. Display techniques that aid in understanding the characteristics of a cluster are disclosed. | 10-25-2012 |
20120271554 | Systems and Methods Utilizing Plethysmographic Data - Disclosed are apparatus, systems and methods utilizing attributes of the cardiac signal to calibrate/normalize components of the plethysmographic (PG) waveform indicating changes in venous and arterial blood volume. In the time-domain, amplitudes of respiratory-induced variations of the DC and AC components of the PG waveform may be calibrated/normalized based on an average amplitude of the PG waveform, e.g., over a respiratory cycle. Similarly, in the frequency domain, respiratory signal strength and side-band signal strength may be advantageously calibrated/normalized based on the strength of the cardiac signal or a harmonic thereof. | 10-25-2012 |
20120271555 | DEVICE FOR MEASURING TISSUE STIFFNESS - This invention relates to measuring stiffness of a biological sample Specifically, the invention relates to a milliprobe indentation device that comprises a force probe and a micromanipulator and uses thereof for measuring stiffness of biological samples | 10-25-2012 |
20120271556 | METHOD AND DEVICE FOR ESTIMATING BIOLOGICAL OR CHEMICAL PARAMETERS IN A SAMPLE, CORRESPONDING METHOD FOR AIDING DIAGNOSIS - This method for estimating biological or chemical parameters in a sample (E) comprises steps consisting of putting ( | 10-25-2012 |
20120271557 | Information Processing Apparatus and User Terminal - Disclosed is an information processing apparatus capable of communicating with a user terminal which acquires a first index value for reflecting a state of a first biological component of a user and evaluating a metabolic result of the first biological component in a certain period of time on the basis of the first biological component and which provides the acquired first index value to the user, wherein calibration curve data is delivered to the user terminal in order to use the calibration curve data for acquiring the first index value. | 10-25-2012 |
20120271558 | SYSTEM AND METHOD FOR IDENTIFYING AND CLASSIFYING RESISTANCE GENES OF PLANT USING HIDDEN MARCOV MODEL - The present invention relates to a system and a method for quickly and accurately identifying and classifying resistance genes of a plant from a protein or DNA sequence. In order to identify and classify resistance genes of a plant using a hidden marcov model, conceived is a profile matrix made using a protein sequence of a domain which is encoded by the resistance genes, and a system for identifying the domain of the resistance genes using the profile matrix and classifying the resistance genes by domain combination. The present invention enables effective identification and classification of the resistance genes of a plant using the profile matrix and program, of which the nucleotide base sequence or protein sequence is detected. | 10-25-2012 |
20120271559 | Determining Analyte Concentrations in Biological Fluids with Abnormal Output Detection - A biosensor has an abnormal output detection system that determines whether an output signal from the redox reaction of an analyte has a normal or abnormal shape or configuration. The abnormal output detection system improves the accuracy and precision of the biosensor in determining whether an output signal has a shape or configuration that may not provide an accurate and/or precise analysis of a biological fluid. The biosensor generates an output signal in response to the redox reaction of the analyte. The biosensor normalizes the output signal and compares the normalized output signal with one or more control limits. The biosensor may generate an error signal when the normalized output signal is not within the control limits. | 10-25-2012 |
20120271560 | Asthma Status Scoring Method and System With Confidence Ratings - A method and system for assessing the health status of a patient, such as the asthma status of a patient, provides an asthma status score and a confidence rating indicative of the score's reliability using continuous real-time data. In some embodiments, the assessment comprises a multidimensional analysis in which asthma status scores and respective confidence ratings are generated for multiple individual asthma health dimensions as well as a summary asthma health dimension indicative of overall asthma health. In some embodiments, the individual dimensions include an environmental trigger dimension based on sensor-based environmental data, a physiological burden dimension based on sensor-based physiological data, a medication adherence dimension based on patient diary data and a perceived symptom dimension based on patient diary data. | 10-25-2012 |
20120277998 | System And Methods For Characterizing A Biological Condition Or Agent Using Selected Gene Expression Profiles - Methods are provided for evaluating a biological condition of a subject using a calibrated profile data set derived from a data set having a plurality of members, each member being a quantitative measure of the amount of a subject's RNA or protein as distinct constituents in a panel of constituents. The biological condition may be a naturally occurring physiological state or may be responsive to treatment of the subject with one or more agents. Calibrated profile data sets may be used as a descriptive record for an agent. | 11-01-2012 |
20120277999 | METHODS, KITS AND ARRAYS FOR SCREENING FOR, PREDICTING AND IDENTIFYING DONORS FOR HEMATOPOIETIC CELL TRANSPLANTATION, AND PREDICTING RISK OF HEMATOPOIETIC CELL TRANSPLANT (HCT) TO INDUCE GRAFT VS. HOST DISEASE (GVHD) - The invention relates to predicting or determining risk of a hematopoietic cell transplant (HCT) from a donor to induce Graft vs. Host Disease (GVHD) in a HCT recipient; to classifying HCT from a candidate donor according to the risk of inducing GVHD in a HCT recipient; and to organizational constructs (e.g., databases) and methods of producing organizational constructs (e.g., databases) in which HCT of one or more candidate donors is classified or scored according to risk of inducing GVHD in a HCT recipient. The invention also relates to kits and arrays useful for predicting or determining risk of HCT from a candidate donor to induce GVHD in a HCT recipient, and for classifying or scoring such donors according to risk of inducing GVHD in a HCT recipient. | 11-01-2012 |
20120278000 | METHOD FOR ASSESSING EFFICACY OF COMBINATION CHEMOTHERAPY, AND PROGRAM AND DEVICE FOR ASSESSING THE SAME - A method for assessing an efficacy of combination chemotherapy, comprising: a first obtaining process for obtaining a specific activity value of Cyclin Dependent Kinase (CDK) 1 and a specific activity value of CDK2 in a biological sample including a carcinoma cell collected from a cancer patient; a second obtaining process for obtaining a GSTπ expression level in the biological sample; and an assessment process for assessing the efficacy of the combination chemotherapy on the cancer patient based on the specific activity values of CDK1 and CDK2 obtained in the first obtaining process and the GSTπ expression level obtained in the second obtaining process. | 11-01-2012 |
20120278001 | Signal Procesing Systems and Methods Using Basis Functions and Wavelet Transforms - According to embodiments, systems and methods are provided that use continuous wavelet transforms and basis functions to provide an optimized system for the determination of physiological information. In an embodiment, the basis functions may be used to refine an area of interest in the signal in frequency or in time, and the continuous wavelet transform may be used to identify a maxima ridge in the scalogram at scales with characteristic frequencies proximal to the frequency or frequencies of interest. In another embodiment, a wavelet transform may be used to identify regions of a signal with the morphology of interest while basis functions may be used to focus on these regions to determine or filter information of interest. In yet another embodiment, basis functions and continuous wavelet transforms may be used concurrently and their results combined to form optimized information or a confidence metric for determined physiological information. | 11-01-2012 |
20120283954 | Method for quantitative analysis of complex proteomic data - This invention is a novel method for analysis of data that is produced by test equipment. The preferred embodiment is data produced by liquid chromatography tandem mass spectrometry (LC-MS/MS) equipment, using industry standard methods to generate the initial data from the test equipment. The invention is a method for processing of the data to promptly produce accurate, reliable, and meaningful data that can be used for critical decisions. The unique benefit of the method is to correct the multiple measurement and calculation errors that are inherent in the operation of laboratory equipment. Prior methods result in errors based on circumstances that are difficult to control, accuracy-related errors in machine measurements, and fundamental mathematical errors in the data processing software that used with the laboratory equipment. As an added benefit, this novel method allows comprehensive simultaneous measurement and calculation of correlation of any and all peptide pairs in a single measurement, with the capability to support repeated measurements with changed conditions over time. This novel method allows robust, detailed, and comprehensive measurements of peptide activity and function, which results in substantial improvements over prior methods in accuracy, reliability, and efficiency. | 11-08-2012 |
20120283955 | METHODS FOR DATA MANIPULATION RELATING TO POLYMER LINEAR ANALYSIS - The invention provides methods for the manipulation and processing of data from direct linear analysis of polymers such as nucleic acids. The resultant processed data is used to identify nucleic acids and/or their biological sources, and/or to identify mutations in the polymers. | 11-08-2012 |
20120283956 | METHOD AND SYSTEM FOR PREDICTING SELECTIVE CANCER DRUG TARGETS - A method for creating a metabolic map of metabolic reactions by selecting metabolic reactions active in cancer cells. A core set of metabolic reactions occurring in the cancer cells is designated. For each permutation, whether inhibition of the k-th non-core reaction together with inhibition of all previously deleted non-core reactions results in inhibition of any of the core reactions or results in inhibition of the flux of biomass metabolites to biomass is determined. If inhibition of the k-th non-core reaction and inhibition of all previously deleted non-core reactions does not result in inhibition of any core reactions and does not result in inhibition of the flux of biomass metabolites to biomass, then the k-th non-core reaction is deleted from the set of non-core reactions. The number of permutations for which the k-th non-core reaction is not deleted is determined and a metabolic map is then created based on that number. | 11-08-2012 |
20120283957 | SYSTEMS AND METHODS FOR DETECTING THE PRESENCE OF A BIOLOGICAL STATUS USING PLOT - Systems and methods for identifying Methicillin resistant strains of | 11-08-2012 |
20120290215 | Calculating and Monitoring a Composite Stress Index - In particular embodiments, a method includes accessing data streams from a first group of physiological sensors monitoring a person, a second group of deconfounding sensors monitoring the person, and a third group of sensors monitoring a stressor, analyzing data sets collected from the person when the person is exposed and not exposed to the stressor, and determining a current stress factor for the stressor with respect to the person based on the analysis. | 11-15-2012 |
20120290216 | Method and System for Distinguishing Nociceptive Pain from Neuropathic Pain - A method of distinguishing nociceptive pain from neuropathic pain includes providing a series of questions for answering by the patient. Each of the answers by the patient are given a numerical value within a nociceptive pain category and a neuropathic pain category. The values within the two categories are then summed, with the resultants potentially modified using a series of one or more equations. The ratio of the neuropathic pain to the nociceptive pain is then calculated. The ratio provides a value for the physician to diagnose the patient as suffering from nociceptive pain, neuropathic pain, or both nociceptive pain and neuropathic pain. Embodiments of the present invention include a system for assisting a physician to identify whether a patient's pain is nociceptive pain or neuropathic pain. | 11-15-2012 |
20120290217 | SYSTEM AND METHOD FOR TRACKING RECORDING AND ANALYZING SPATIAL ACTIVITY OF A SUBJECT FOR MEDICAL AND OTHER APPLICATIONS - The present invention is a method, circuit and system for characterizing one or more aspects of a subject's physical condition based on data generated by a localization device, such as an accelerometer, an inertial navigation system (INS), a global positioning system (GPS) unit or any combination thereof, carried by or affixed to the subject. | 11-15-2012 |
20120290218 | Computational Analysis of the Synergy Among Multiple Interacting Factors - A method is provided for selecting two or more genes from gene expression data. In the method, gene expression data for a plurality of genes is provided, where the gene expression data include expression levels for each of the plurality of genes. The gene expression data is discretized. Based on the discretized gene expression data, the synergy among the plurality of genes with respect to a phenotype, for example, presence or absence of a disease in a tissue, is evaluated. Two or more genes whose synergy exceeds a predetermined threshold are selected. A system implementing the method is also provided. | 11-15-2012 |
20120296569 | METHOD AND SYSTEM FOR WEIGHTED ANALYSIS OF NEUROPHYSIOLOGICAL DATA - A method of analyzing neurophysiological data is disclosed. The method comprises: identifying activity-related features in the data, constructing a brain network activity (BNA) pattern having a plurality of nodes, each representing a feature of the activity-related features, and assigning a connectivity weight to each pair of nodes in the BNA pattern. | 11-22-2012 |
20120296570 | DEVICE AND METHOD FOR MULTIPARAMETER MEASUREMENTS OF MICROPARTICLES IN A FLUID - The invention relates to a method of classifying and flow measuring the refringence of at least two populations of particles present in a fluid. The method uses a light source that has small coherence time, with a coherence length Lc<100 μm, that is used under extinction conditions at a center wavelength selected as a function of a range of volumes and of a range of refractive indices expected for the particles under consideration. The method uses a device that, together with the light source, forms a converging illuminating beam of aperture angle that is selected as a function of the range of volumes and the range of refractive indices expected for the particles under consideration at the selected center wavelength. | 11-22-2012 |
20120296571 | ORGANISM INFORMATION MEASURING INSTRUMENT, PORTABLE TERMINAL DEVICE, ORGANISM INFORMATION MEASURING METHOD, AND PROGRAM - An organism information measuring instrument of the present invention includes: a sensor that measures organism information; a normalization circuit that normalizes the organism information by converting a value of the organism information based on preset normalization information; and a reliability information generation circuit that detects a change amount greater than or equal to a predetermined value in a predetermined time period, with respect to the organism information or the normalized organism information, and generates reliability information indicating lower reliability as the change amount is greater. | 11-22-2012 |
20120303282 | Melatonin Suppression Extent Measuring Device - The present invention relates to a melatonin suppression extent measuring device, comprising: a light receiving unit, a first processing unit, a first memory unit, a second processing unit, a second memory unit, a display unit, and a power management unit, wherein the light receiving unit is able to receive a light signal and transmit the light signal to the first processing unit; The first processing unit can process the light signal to a spectral data, and furthermore, the second processing unit can process the spectral data to a percent value of melatonin suppression and show the percent value of melatonin suppression in the display unit, so that human can exactly know how many melatonin suppression extent are caused by the light environment which is exposing himself body. | 11-29-2012 |
20120303283 | Polymerase Preference Index - Disclosed is a method for calculating a Polymerase Preference Index (PPI) for potential primers for DNA sequencing and/or amplification, and thereby increasing the efficiency of DNA sequencing and/or amplification performed using primers selected according to their PPI number. | 11-29-2012 |
20120303284 | DETERMINATION OF TIMING OF CHEMOTHERAPY DELIVERY - A system and method for determination of one or more favorable time(s) for chemotherapy or other pharmacological treatment delivery analyze time-dependent fluctuations of at least one biological variable measured in blood samples obtained from clinical patients and determine one or more favorable times for the pharmacological treatment of the patient. In some examples, the biological variables are immune variables. | 11-29-2012 |
20120303285 | METHOD AND SYSTEM FOR COMPARATIVE GENOMICS - A method and system for representing a similarity between at least two genomes that includes detecting gene clusters which are common to the at least two genomes and representing the common gene clusters in a PQ tree. The PQ tree includes a first internal node (P node), that allows permutation of the children thereof, and a second internal node (Q node), that maintains unidirectional order of the children thereof. | 11-29-2012 |
20120310537 | IDENTIFICATION OF ABERRANT MICROARRAY FEATURES - Described herein is a method for identifying an aberrant feature on a nucleic acid array. In general terms, the method comprises: a) obtaining a log transformed normalized value indicating the amount of hybridization of a test sample to a first feature on the nucleic acid array; b) calculating a z-score for the first feature using: the log transformed normalized value; and the distribution of reference log transformed normalized values that indicate the amount of hybridization of control samples to the same feature on a plurality of reference arrays; and c) identifying said test feature as aberrant if it has a z-score that is above or below a defined threshold. | 12-06-2012 |
20120310538 | System and Method for Diagnosing a Biological Sample - The present disclosure provides for a system and method for analyzing biological samples to thereby provide a diagnosis. A system may comprise an illumination source, a filter and a detector configured to generate at least one of: a visible data set representative of a biological sample, a SWIR data set representative of a biological sample, and combinations thereof. A method may comprise illuminating a biological sample to generate a plurality of photons, filtering a said plurality of interacted photons, detecting | 12-06-2012 |
20120310539 | PREDICTING GENE VARIANT PATHOGENICITY - A computer-implemented, gene-specific prediction tool for classifying and interpreting gene tests is described. The prediction tool includes a predictor using a consensus framework. The predictor employs a weighted metric of existing and complementary prediction algorithms and calculated reference intervals of disease outcomes to calculate a consensus score used in interpreting gene tests. | 12-06-2012 |
20120310540 | SYSTEMS AND METHODS FOR ESTIMATING PHOTOSYNTHETIC CARBON ASSIMLATION - Methods, devices, and systems for measuring carbon assimilation based on simultaneous or near-simultaneous measurements of chlorophyll fluorescence and stomatal conductance of plant. A sample containing chlorophyll, such as a plant leaf, is illuminated with light, e.g., in the form of a single saturating pulse or multiple pulses, and chlorophyll fluorescence and stomatal conductance of the chlorophyll sample are measured. A porometer or infra-red gas analyzer is used to measure stomatal conductance and a photodetector is used to measure fluorescence. A carbon assimilation value for the chlorophyll sample is determined using the measured chlorophyll fluorescence and the measured stomatal conductance. | 12-06-2012 |
20120310541 | ONLINE DETERMINATION OF INTER ALIA FAT, PROTEIN, LACTOSE, SOMATIC CELL COUNT AND UREA IN MILK BY DIELECTRIC SPECTROSCOPY BETWEEN 0.3 MHZ AND 1.4 GHZ USING CHEMOMETRIC EVALUATION - A method for determining a concentration of at least one component of milk includes measuring impedance values between two electrodes associated with a cell containing a milk sample at each of at least three frequencies, and estimating a concentration of the at least one component from a polynomial expression in which the impedance values at the at least three frequencies are variables. A system for determining a concentration of at least one component of milk includes a sampling cell including a milk sample, electrodes operative to electrify the milk sample with excitation signals at a plurality of frequencies including at least three frequencies, a signal generator for generating the excitation signals, circuitry for determining a relationship between an amplitude and phase of reflected and incident signals obtained from the signal generator, and a processor that receives the relative amplitude and phase and estimates a concentration of at least one component of milk based on a polynomial expression relating measured impedance values at a plurality of frequencies to concentrations of at least one component of milk. | 12-06-2012 |
20120310542 | METHOD FOR DETERMINING A PARAMETER REPRESENTATIVE OF THE STATE OF VIGILANCE OF A VEHICLE DRIVER - A method for determining a parameter representative of the state of vigilance of a vehicle driver, from the measurement of the steering wheel angle of the vehicle includes determining two successive ranges of temporal windows: a first range of temporal windows T(t | 12-06-2012 |
20120316793 | METHODS AND SYSTEMS FOR INDICATING BEHAVIOR IN A POPULATION COHORT - Avatars, methods, apparatuses, computer program products, devices and systems are described that carry out identifying a member of a population cohort; and indicating at least one behavior in the member of the population cohort based on an association between the population cohort and at least one cohort-linked avatar. | 12-13-2012 |
20120316794 | METHOD AND A SYSTEM FOR MONITORING A PHYSIOLOGICAL PARAMETER OF A SUBJECT - Embodiments provide a method which includes transmitting, by a receiving device (RD), a request message which includes a receiving device identification number (RDIN); receiving, by the RD, a registration message including a measuring device identification number (MDIN) from a measuring device (MD); registering, by the RD, the MD by means of the MDIN if the registration message from the MD includes the RDIN; receiving, by the RD, one or more data messages from the MD, each data message including the MDIN and a physiological parameter; and processing the physiological parameter in each data message, by the RD, if the MD has been registered by the RD. The range of the transmission of the request message between the RD and the MD is shorter than the range of the transmission of each data message between the MD and the RD, and/or the range of the transmission of the registration message between the MD and the RD is shorter than the range of the transmission of each data message between the MD and the RD. Embodiments also provide a corresponding monitoring system. | 12-13-2012 |
20120323496 | Tracking of User Performance Metrics During a Workout Session - Example embodiments may relate systems, methods, apparatuses, and computer readable media configured to process input specifying a user attribute, adjust a performance zone based on the user attribute, receive data generated by at least one of an accelerometer and a force sensor, determine whether the data is within the performance zone, and output the determination. | 12-20-2012 |
20120323497 | Non-Hypergeometric Overlap Probability - Methods, software, and systems are provided for determining the probability of an overlap set of entities having an overlap size, where the overlap set is independently selected from two sets of non-identical entities. Applications of the invention to microarrays are provided. Probability distributions are provided for determining the probability that the size of an overlap gene set from two different microarrays occurs by chance. Microarray analysis for determining the size of a statistically significant overlap gene set given two different microarrays is described. Overlap set size probability determinations that account for the total number of genes in two different microarrays and not just the common genes are described. | 12-20-2012 |
20120330555 | Analyte Testing System with Docking Station for Data Management - An analyte testing system having an analyte testing device and a docking station is described. The analyte testing device includes a plurality of lancets, a plurality of analyte sensors, electronics for deriving test data from the analyte sensors, a visual display that displays test data, and a data recording facility that records non-test data. Examples of non-test data include text diary information, audio diary information, food eaten, minutes exercised, medication taken, and estimated calories burned. The docking station has a power interface and data interface that provide power and data connectivity to the testing device. The docking station also has a storage facility configured to automatically store the test data and non-test data. | 12-27-2012 |
20120330556 | Analyte Testing System with Docking Station for Data Management - An analyte testing system having an analyte testing device and a docking station is described. The analyte testing device includes a plurality of lancets, a plurality of analyte sensors, electronics for deriving test data from the analyte sensors, a visual display that displays test data, and a data recording facility that records non-test data. Examples of non-test data include text diary information, audio diary information, food eaten, minutes exercised, medication taken, and estimated calories burned. The docking station has a power interface and data interface that provide power and data connectivity to the testing device. The docking station also has a storage facility configured to automatically store the test data and non-test data. | 12-27-2012 |
20120330557 | System for Cardiac Condition Analysis Based on Cardiac Operation Patterns - A system for heart performance monitoring stores image data representing a sequence of medical images of a surface of a patient heart acquired over multiple contraction and reperfusion cycles. An image data processor automatically processes the image data to determine, change in displacement of selected points of a region of interest of the heart surface over individual cycles of the multiple contraction and reperfusion cycles, maximum and minimum peak displacement points and associated relative times of occurrence of the maximum and minimum peak displacement points and individual parameters related to change in displacement of corresponding individual points of the selected points. A display image shows a grid of individual parameters and an individual grid cell employs a visual attribute to visually indicate degree of change in an associated individual parameter occurring over the multiple contraction and reperfusion cycles. | 12-27-2012 |
20120330558 | IDENTIFICATION OF BIOMARKERS - The present invention relates to a method comprising the steps of obtaining a sample from the subject, measuring a plurality of biomolecules in the sample, identifying the measured biomolecules in the sample, characterized in that the method further comprises the steps of estimating a discriminatory ability of each measured biomolecule by using a paired test hypothesis, and integrating the estimated discriminatory abilities of the biomolecules into a kinetic analysis. More particularly, the present invention enables the use of such a method and a method for monitoring progress or treatment of a disease such as cardiovascular diseases. Such identification methods comprising the steps of obtaining a sample from the subject, measuring a plurality of biomolecules in the sample and identifying the measured biomolecules can particularly be used for monitoring progress or treatment of a disease. | 12-27-2012 |
20120330559 | SYSTEMS AND METHODS FOR HYBRID ASSEMBLY OF NUCLEIC ACID SEQUENCES - Systems and methods for assembling a nucleic acid sequence are disclosed. A plurality of single fragment sequence reads and a plurality of paired fragment sequence reads are received. Each paired fragment sequence read comprises at least two sequence reads separated by an insert. Single fragment sequence reads are assembled into a plurality of contigs, and the paired fragment sequence reads are mapped to the contigs. Further, gap regions comprising a portion of the partially assembled nucleic acid sequence for which the single fragment sequence reads do not map are identified, and hanging pairwise sequence reads of the mapped paired fragment sequence reads are used to fill in the gap region. | 12-27-2012 |
20120330560 | METHOD AND SYSTEM FOR PREDICTING PERTUBATIONS ALTERING METABOLIC STATES - A computer implemented method for identifying genetic or environmental perturbations that induce a transformation from a source state of an individual to a target state. A flux description of reactions is calculated in the source state and a statistical test is performed on the gene expression levels of the source state versus the target state, to generate a P-value for each on the plurality of genes. Then, for each reaction the flux of the reaction in the source state is fixed and a solution for all of the fluxes that minimize an objective function is found. These perturbations are ranked by the extent by which the perturbation caused a transformation of the source state towards the target state. | 12-27-2012 |
20120330561 | METHOD AND APPARATUS FOR PROVIDING DATA PROCESSING AND CONTROL IN A MEDICAL COMMUNICATION SYSTEM - Methods and apparatus for providing data processing and control for use in a medical communication system are provided. | 12-27-2012 |
20120330562 | VARIABLE INDICATION ESTIMATOR - A variable indication estimator which determines an output value representative of a set of input data. For example, the estimator can reduce input data to estimates of a desired signal, select a time, and determine an output value from the estimates and the time. In one embodiment, the time is selected using one or more adjustable signal confidence parameters determine where along the estimates the output value will be computed. By varying the parameters, the characteristics of the output value are variable. For example, when input signal confidence is low, the parameters are adjusted so that the output value is a smoothed representation of the input signal. When input signal confidence is high, the parameters are adjusted so that the output value has a faster and more accurate response to the input signal. | 12-27-2012 |
20120330563 | Assembly Error Detection - A method for detecting errors in genetic sequence assemblies including defining an assembly (A) of a sequence of genetic data, collecting read data into a library of reads (L), plotting histograms of sizes or reads versus a number of reads per size, normalizing a distribution (D) with a coverage C to obtain D′ that has a mean (μ) and standard deviation (σ) and reserve positions (i) not used to obtain D′, collecting subset of reads (S | 12-27-2012 |
20120330564 | Method of Pre-Treatment and Staining of a Biological Sample and Device for Support of a Biological Sample and Methods of Using Such Device - There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information. | 12-27-2012 |
20120330565 | SYSTEM AND METHOD FOR EVALUATING PHYSIOLOGICAL PARAMETER DATA - Embodiments disclosed herein may include systems and methods for evaluating physiological parameter data. Embodiments of methods may include monitoring a patient to produce a signal comprising a sequence of numerical values for a physiological parameter over a time period, calculating an index from the signal, comparing the index to a reported index, and if the index is greater than the reported index, setting the reported index to the value of the index. Embodiments of methods may include calculating a modulation of the signal, comparing the modulation to a previous valise of the modulation to identity a trend in the modulation and if the trend corresponds to an undesirable condition, using a first function, to increase the reported index. Embodiments of methods may include providing an indication of a physiological status based on the reported index. | 12-27-2012 |
20130006536 | HAND-HELD TEST METER WITH UNPOWERED USB CONNECTION DETECTION CIRCUIT - A hand-held test meter for use with an analytical test strip in the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes a housing, a test meter control circuit block, and a Universal Serial Bus (USB) connector block that includes an unpowered USB connection detection circuit block. The unpowered USB connection detection circuit block is configured to provide a shielding signal of a first potential (for example, a high-level signal) to the test meter circuit control block when a USB connection to an external device has been made to the USB connector block and a shielding signal of a second potential (such as a low-level signal representative of ground) to the test meter control circuit block when a USB connection to a an device has been made to the USB connector block. In addition, the test meter control circuit block is configured to interrupt operation of the hand-held test meter when the shielding signal of the second potential is received from the USB connector block. | 01-03-2013 |
20130006537 | CONTROLLING A PROCESS OF MONITORING THE POSITION OF A PATIENT DURING A RADIATION TREATMENT - The invention is directed to a method for controlling a process of monitoring the position of at least a part of a patient's body ( | 01-03-2013 |
20130013213 | METHODS AND APPARATUS FOR IDENTIFICATION OF DISEASE ASSOCIATED MUTATIONS - In some embodiments, a non-transitory processor-readable medium includes code to cause a processor to receive a set of variants identified by a comparison of a test DNA sequence with a reference DNA sequence and associate at least one of the set of variants with at least one of a set of annotations each indicative of at least one criterion. The code includes code to cause the processor to filter, based on the set of annotations, the set of variants to identify a subset of variants from the set of variants. Each variant from the subset of variants is associated with at least one common annotation from the set of annotations. The code further includes code to cause the processor to present the subset of variants such that the subset of variants can be used to render a clinical diagnosis. | 01-10-2013 |
20130013214 | METHOD AND APPARATUS FOR CORRELATING LEVELS OF BIOMARKER PRODUCTS WITH DISEASE - In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies. | 01-10-2013 |
20130013215 | COMPUTATIONAL METHODS FOR PROTEIN STRUCTURE DETERMINATION - A screening method for determining secondary structures of a protein or polypeptide without performing computer simulation, is provided. The screening method is based in part on the interaction between the electrostatic forces and the electrostatic displacement forces in the protein, and makes use of a set of computational conditional statements. The screening method includes determining both alpha helix and beta sheet structures based on hydrophobic character and charges of the residues, among other considerations. A method for determining an overall folded structure of a protein using a physics-based simulation method with an initial configuration of the protein prepared according to the secondary structure(s) determined by the screening method, is also provided. | 01-10-2013 |
20130013216 | LIBRARIES AND DATA STRUCTURES OF MATERIALS REMOVED BY DEBULKING CATHETERS - Material removed by a debulking catheter from a body lumen can be preserved. Materials can be collected from many different patients and/or from multiple procedures on individual patients. Data which describe the properties or qualities of the removed material and/or the patient and/or the patient's family or environment can be stored on computer readable media. The stored data can be used to draw correlations, to stratify groups of patients, to provide risk assessments, to provide diagnoses and/or prognoses. Further tests can be done on the stored materials at later times after the procedures have been completed. | 01-10-2013 |
20130013217 | METHODS AND SYSTEMS FOR GENOMIC ANALYSIS USING ANCESTRAL DATA - The present disclosure provides methods and systems for assessing an individual's genotype correlations to a phenotype by analyzing the individual's genomic profile and using ancestral data to determine the correlations between genotypes and phenotypes. | 01-10-2013 |
20130013218 | SYSTEMS AND METHODS FOR EVALUATING ENVIRONMENTAL ASPECTS OF SHIPPING SYSTEMS - According to various embodiments, package evaluation systems and methods are provided for evaluating the sustainability of packaging used in the shipment of goods. In particular, the package evaluation systems and methods are configured for performing package evaluations and managing and providing access to data resulting from package evaluations. The package evaluations are designed to assess, among other things, the ability of sample packages to prevent damage to their contents, the volumetric efficiency of sample packages, and the sustainability of the materials used to construct sample packages. In addition, the systems and methods are further configured for assigning a certification to an entity associated with the evaluated packages based on the results of the evaluation. | 01-10-2013 |
20130013219 | Determining Susceptibility To A Sudden Cardiac Event - Disclosed herein is a method of do terming the likelihood of a sudden cardiac event, such as an arrythmia, in a subject. Also disclosed is a method of determining whether a subject is at risk of a sudden cardiac event arid whether the subject would benefit from a treatment such as implantation of an ICD. | 01-10-2013 |
20130018589 | DATA CONVERSION IN ECG TECHNIQUESAANM Yuk; JongtaeAACI RedmondAAST WAAACO USAAGP Yuk; Jongtae Redmond WA US - A computer-implementable method includes generating a first set of input signals representing an X-lead ECG apparatus, generating a second set of input signals based on the first set and representing a Y-lead ECG apparatus, and generating to a display device a set of ECG traces and/or a diagnosis of acute myocardial infarction based on the second set. X and Y are integer values and Y is greater than X. | 01-17-2013 |
20130018590 | EVENT DOSIMETER DEVICES AND METHODS THEREOF - A dosimetry device includes at least one sensor in a housing and a dosimetry processing device with a memory. The dosimtery processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the sensor; storing the readings; conducting an analysis of the stored readings to determine an injury risk assessment; and outputting at least one of the conducted analysis of the determined injury risk assessment or the stored readings. | 01-17-2013 |
20130018591 | FAST TOMOGRAPHIC MICROWAVE IMAGING - Microwave imaging equipment utilizing an array of antennas operated to collect electromagnetic field information for a material being imaged. Image processing method and apparatus use the discrete dipole approximation (DDA) and drastically reduce the time required to process the measured data and estimate the properties of the material. Prior to interrogating the material, interaction matrices are generated and stored for future DDA calculations. The interaction matrices relate to the interaction between the antennas, the operating frequency, the background medium, and the location of the discretizing dipoles. An initial guess of the material properties is made and the resultant field is estimated. These results are compared to the measured results and incremental changes in the material property are computed. The updated material properties are used to recalculate the field. Comparison of the field to the measured field and updating of the material properties continues until an end criterion is satisfied. | 01-17-2013 |
20130018592 | Systems and Methods for Inter-Population Neurobehavioral Status Assessment Using Profiles Adjustable to Testing Conditions - Systems and methods for inter-population assessment of neurobehavioral status employ neurobehavioral profiles to accommodate differing external conditions. Population profiles and external condition data are provided to a neurobehavioral performance model to determine neurobehavioral status under external conditions. Alternatively, neurobehavioral performance values may be retrieved from the profile when such values are stored in conjunction with external condition data. Comparisons of the resulting neurobehavioral status(es) are then determined, and may comprise without limitation one or more of: performance deltas, statistical parameter differences, rankings, above/below performance threshold determinations, pass/fail indicators, and countermeasure recommendations. Populations may comprise pluralities, individuals and empty (“null”) sets. Comparisons may also pertain to one or more relevant times of interest and one or more sets of testing conditions. Fields of application include (without limitation) operational and military fatigue management, medical diagnosis and treatment, fatigue countermeasure training and individualization, sleep research, academic and scientific research, and/or the like. | 01-17-2013 |
20130018593 | MULTI-STAGE, REGRESSION-BASED PCR ANALYSIS SYSTEM - Systems and methods are provided for analyzing data to determine properties of a PCR process or other process exhibiting amplification or growth. Data representing an amplification can be distinguished from data representing a jump or other error. A modified sigmoid function containing a drift term may be used in determining the properties. A multi-stage functional fit of the amplification data can provide increased accuracy and consistency of one or more of the properties. A baseline of the amplification data can be determined by analyzing an integrated area of a first derivative function of the data. A reference quantitation value can also be determined from locations of maxima of different derivative functions of the amplification data, e.g., a weighted average of the maxima locations for the second and third derivatives may be used. | 01-17-2013 |
20130018594 | APPARATUS AND METHOD FOR IDENTIFYING SECONDARY STRUCTURE OF PROTEIN USING ALPHA CARBON COORDINATESAANM Cho; Kwang-HwiAACI SeoulAACO KRAAGP Cho; Kwang-Hwi Seoul KRAANM No; Kyoung-TaiAACI SeoulAACO KRAAGP No; Kyoung-Tai Seoul KRAANM You; Min-JaeAACI SeoulAACO KRAAGP You; Min-Jae Seoul KR - This invention relates to an apparatus and method for identifying the secondary structure of a protein using alpha carbon coordinates. The apparatus includes a pseudo center fixing unit receiving a series of alpha carbon coordinates of amino acid sequences of a target protein so that pseudo centers corresponding to respective alpha carbons are disposed at positions fixed between the respective alpha carbons and alpha carbons adjacent thereto; a helix determination unit determining, based on a dihedral angle and a distance between a preset number of consecutive pseudo centers, whether the secondary structure formed by amino acids corresponding to the consecutive pseudo centers is a helix; and a strand determination unit determining, based on distances between pseudo centers of different pseudo center sequences in a plurality of pseudo center sequences having a preset number of consecutive pseudo centers among pseudo centers other than those corresponding to the helix, whether the secondary structure formed by amino acids corresponding to the pseudo centers of respective pseudo center sequences is a strand. According to this invention, the secondary structure including amino acids corresponding to pseudo centers can be identified based on the dihedral angle or the distance between pseudo centers using pseudo centers fixed between alpha carbons, thus attaining increased accuracy, compared to conventional methods using alpha carbon coordinates. | 01-17-2013 |
20130018595 | COPD EXACERBATION DETECTION USING SPUTUM ANALYSIS - Subject of the invention is the diagnosis and/or monitoring of chronic obstructive pulmonary disease based on sputum rheology. The complex modulus i.e. the viscous modulus and the elastic modulus of sputum is measured and assessed in respect of chronic obstructive pulmonary disease. | 01-17-2013 |
20130024123 | METHODS AND SYSTEMS FOR DETERMINING PHYSIOLOGICAL PARAMETERS USING TEMPLATE MATCHING - A patient monitoring system may be configured to use template matching in determining physiological parameters. A physiological signal may be monitored, and a wavelet transform may be performed. The wavelet transform, or parameters derived thereof such as energy distribution or relative phase difference, may be compared with one or more templates using template matching. Templates may be based on, for example, physiological data, mathematical models, or look-up tables, and may be pre-computed and stored. Physiological parameters may be determined based on the template matching results. Scale variability, confidence metrics, or both, may be used to aid in determining the physiological parameter. | 01-24-2013 |
20130024124 | SYSTEMS, METHODS, AND APPARATUS FOR PREVENTING RECIDIVISM - Systems, apparatus, methods and articles of manufacture provide for assessing a likelihood of recidivism for persons (e.g., patients, injured workers). In some embodiments, information such as claim information, employment information, personal information, and/or medical information, may be used in determining a recidivism score or other indication or measure of a likelihood of recidivism. | 01-24-2013 |
20130024125 | STATISTICAL ANALYSIS OF MEDICAL THERAPY OUTCOMES - A method for evaluating a medical therapy with a computing device comprises accessing a data storage system to obtain baseline characteristics for a population of patients who each receive a medical therapy, accessing baseline characteristics and one or more post-therapy outcomes for a subset of the population, and accessing an association between the baseline characteristics and the post-therapy outcomes in the subset. The method further includes modeling the distribution of the post-therapy outcomes in the population based on the distribution of the post-therapy outcomes in the subset and further based on a comparison of the distribution of the of the baseline characteristics in the subset with the distribution of the baseline characteristics in the population, and storing an indication of the modeled distribution of the post-therapy outcomes in the population of patients on the data storage system. | 01-24-2013 |
20130024126 | METHOD AND A CORRECTION SYSTEM FOR CORRECTING TRACER-UPTAKE MEASUREMENTS - This invention relates to a method and a correction system for correcting tracer-uptake measurements for patient specific variations in the tracer-uptake. Input data are received about the patient and subsequently it is determining whether the received input data include tracer-impact data that impact the tracer-uptake measurements for the patient. In case the tracer-impact data are included in the input data a comparing is performed where the tracer-impact data are compared with pre-stored reference data that have associated thereto a correction indicator indicating an amount of deviation of the tracer-uptake measurement due to the tracer-uptake dependent data. The correction indicator of the pre-stored reference data that match with the tracer-impact data is then used to correct the tracer-uptake measurements for the patient. | 01-24-2013 |
20130024127 | DETERMINATION OF SOURCE CONTRIBUTIONS USING BINOMIAL PROBABILITY CALCULATIONS - This invention relates to calculation of percent contribution of data from a major source and a minor source in a sample. | 01-24-2013 |
20130024128 | METHOD FOR ESTIMATING A BLOOD SUGAR CONDITION - A blood sugar condition is estimated by measuring a urine sugar value, discriminating whether it is less than a discriminating method classification boundary value, when it is less, obtaining an averaged value of measured urine sugar values during a past predetermined period of time, measured at the same time of day as the latest measurement, calculating the difference between the averaged and measured urine sugar values, when the difference is not less than a positive discriminating reference difference, discriminating as being a blood sugar value decrease, when the measured value is not less than the discriminating method classification boundary value, obtaining an averaged value of all measured values during the past predetermined period of time, calculating a ratio between the measured and averaged values, and, when the ratio is not greater than a first discriminating reference ratio, discriminating as being the blood sugar value decrease. | 01-24-2013 |
20130024129 | DETECTING CHEMICAL COMPONENTS FROM SPECTROSCOPIC OBSERVATIONS - Embodiments disclosed herein may include methods and systems capable of estimating the underlying concentrations of chromophores in a sample. The photon scattering and absorption model may be based on Laplace and stable distributions, which may reveal that measurements in diffuse reflectance may follow a Beer-Lambert and Kohlrausch-Williams-Watts (KWW) product. This Beer-Lambert portion of the product may dominate in high absorption sample areas, while the KWW portion of the product may dominate in low absorption sample areas. | 01-24-2013 |
20130030711 | METHOD AND APPARATUS FOR PROVIDING ADAPTIVE FILTERING OF SENSORS AND SENSOR DATA - An approach is provided for adaptive filtering of sensors and sensor data. A sensor manager determines one or more signals associated with one or more sensors. The sensor manager then processes and/or facilitates a processing of the one or more signals for comparison against one or more predetermined signals. The sensor manager determines one or more parameters for one or more filters based, at least in part, on the comparison, wherein the one or more filters operate, at least in part, on the one or more sensors, one or more other signals determined form the one or more sensors, or a combination thereof. | 01-31-2013 |
20130030712 | METHODS FOR THE SURVEY AND GENETIC ANALYSIS OF POPULATIONS - The present invention relates to methods for performing surveys of the genetic diversity of a population. The invention also relates to methods for performing genetic analyses of a population. The invention further relates to methods for the creation of databases comprising the survey information and the databases created by these methods. The invention also relates to methods for analyzing the information to correlate the presence of nucleic acid markers with desired parameters in a sample. These methods have application in the fields of geochemical exploration, agriculture, bioremediation, environmental analysis, clinical microbiology, forensic science and medicine. | 01-31-2013 |
20130030713 | METHODS OF ASSOCIATING AN UNKOWN BIOLOGICAL SPECIMEN WITH A FAMILY - The present invention provides a method of predicting whether an unknown biological specimen originates from a member of a particular family. The method compares DNA profiles from at least one unknown biological specimen to DNA profiles of more than one family member, which significantly increases the methods' predictive ability. In particular, the invention describes a method of comparing test DNA profiles from unknown biological specimens to a family pedigree comprising target DNA profiles obtained from biological specimens of family members. In one embodiment, a modified Elston Stewart algorithm is used to determine a probability that a genetic relationship exists between at least one unknown biological specimen and the family pedigree. | 01-31-2013 |
20130035864 | Technique for identifying association variables - During a method, an apparatus determines patterns of occurrence of compound variables based on a set of mathematical interactions and patterns of occurrence of a set of biological variables of a group of life forms. Then, the apparatus calculates statistical relationships corresponding to a pattern of occurrence of a trait in the group of life forms and the patterns of occurrence of the compound variables. Moreover, the apparatus determines numbers of occurrences of biological variables that were used to determine compound variables in at least a statistically significant subset of the compound variables, and determines numbers of different mathematical interactions that were used to determine the compound variables in the subset of the compound variables for the biological variables that are associated with the corresponding numbers of occurrences. Next, the apparatus identifies one or more of the biological variables as one or more association variables based on the numbers of occurrences and the numbers of different mathematical interactions. | 02-07-2013 |
20130035865 | SYSTEMS AND METHODS FOR DETECTING GLUCOSE LEVEL DATA PATTERNS - Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges. | 02-07-2013 |
20130035866 | INSTRUMENT AND METHOD FOR ACQUIRING SIGNALS AND IMAGES RELATING TO THE GASTROINTESTINAL TRACT - This invention relates to an apparatus and method for improving detection by equipment used to detect magnetic susceptibility. The advantages provided are related to different factors, such as reduced instrumentation cost, performance in terms of stability and sensitivity, etc. The devices may be used, for example, to detect magnetic tracers and markers in the gastrointestinal tract of animals and humans. They can be used in research and/or for diagnostic purposes using information related to a variety of parameters of the gastrointestinal tract, such as, pharyngeal and oesophageal transit time, gastric emptying and motility, colonic motility, inter alia. | 02-07-2013 |
20130035867 | INTENSITY NORMALIZATION IN IMAGING MASS SPECTROMETRY - The present invention relates generally to a species (analyte) separation and analysis system, for instance a spectrometry system, comprising a processor for receiving and processing signals from said its detector to remove undesirable variation or noise before further processing into a spectrum, whereby the processor is programmed by a novel program, for a normalization preprocessing of the signals of said separation and analysis system. | 02-07-2013 |
20130035868 | METHOD FOR QUANTIFYING THE EXTENT OF HUMAN-INTRODUCED VARIABILITY IN MEDICAL TEST DATA - A method for quantifying the extent of human-introduced variability in medical test data relative to one or more standards for comparable medical tests, the method comprising the following steps: providing user medical test data; comparing the user medical test data against one or more standards for comparable medical tests to determine the extent of deviation of the user medical test data from the one or more standards; and generating a variability-value corresponding to the maximum absolute percentage deviation of the user medical test data from the one or more standards over a predefined operating range of values for the one or more standards. | 02-07-2013 |
20130041590 | Group Performance Monitoring System and Method - The present invention provides a group monitoring device for monitoring a plurality of individuals engaged in an athletic activity, the device including a display configured to display, during an athletic activity: a metric relating to each of a plurality of individuals engaged in the athletic activity, and a status of a system component used to monitor the athletic activity. The group monitoring device may also include an input configured to allow manipulation of the display. | 02-14-2013 |
20130041591 | MULTIPLE MEASUREMENT MODE IN A PHYSIOLOGICAL SENSOR - In a physiological sensor that estimates a true parameter value by providing a predicted parameter value, multiple measurements are taken to increase the accuracy of the predicted parameter value. The sensor can be reapplied between measurements to decrease the probability of an erroneous prediction caused by sensor misplacement. Some measurements can be discarded before calculating a predicted parameter value. The physiological sensor can have a plurality of modes, with one of the modes corresponding to multiple measurement process. | 02-14-2013 |
20130041592 | Method And System Using Computer Simulation For The Quantitative Analysis Of Glycan Biosynthesis - This invention provides a quantitative analysis of glycan biosynthesis along meta pathways using computer simulation for comparing a computer generated spectrum to experimental data to quantitatively track the biosynthesis. Computer simulating the mass spectra of isotopic detection of aminosugars with glutamine experiments allows modeling the glycan biosynthesis over time, via changes in the | 02-14-2013 |
20130046477 | Systematic distillation of status data relating to regimen compliance - Configuration technologies for cost-effectively monitoring indicia of regimen compliance or noncompliance in response to one or more indications of symptoms or actions or other data on data-bearing media or in wireless transmissions, such as implementing techniques for providing or preventing access or otherwise acting on or communicating incremental or definitive indicia of compliance or noncompliance. | 02-21-2013 |
20130046478 | SYSTEM AND METHOD OF INCREASING SAMPLE THROUGHPUT - Technologies for increasing sample throughput by predicting the end point response time of a sensor for the analysis of an analyte in a sample are disclosed. In one aspect, a system includes a sensor that generates data signals associated with the measurement of an analyte within the sample. A processor records appropriate data points corresponding to the signals, converts them to a logarithmic function of time scale, and plots the converted data points. The processor then determines a curve that fits the plotted data points and determines a curve fitting equation for the curve. Once the equation is determined, the processor extrapolates an end point response of the sensor using the equation. A value, such as analyte concentration, is then calculated using the extrapolated end point response. | 02-21-2013 |
20130046479 | WHOLE CROP BIOFUEL PRODUCTION (WCBP) - A computerized method of using a data processor having a memory to account for carbon flows and determine a regulatory value for a biofuel can include (i) storing, in memory, a first set of one or more carbon flow values characterizing the production and use of a biofuel derived from a first fraction of an agricultural biomass, (ii) storing, in memory, a second set of one or more carbon flow values characterizing the production and use of a co-product from a second fraction of the agricultural biomass, wherein the second fraction comprises an agricultural residue and wherein the co-product mitigates anthropogenic greenhouse gas emission, and (iii) calculating, using the data processor, a regulatory value for the biofuel from the first and second sets of carbon flow values. | 02-21-2013 |
20130046480 | AUTOMATIC ANALYSIS DEVICE AND AUTOMATIC ANALYSIS METHOD - There is provided a technique for automatically determining or predicting a line range specific to a sample that appears in a reaction curve in an automated analyzer for mixing a specimen and a reagent and measuring a change in a mixture of the specimen and the reagent with time. This invention approximates reaction curve data by a function and automatically determines a curve part at an early stage or a second stage of a reaction. The invention determines a line range not including a curve part for each sample and calculates a laboratory test value using absorbance data within the determined line range. This invention also automatically determines a start time of line at the early stage of the reaction on the basis of absorbance data obtained up to a point halfway through the reaction curve, predicts a line range on the basis of the end time of line and a planned end time of line, and calculates a predictive value on the basis of a result of the prediction. | 02-21-2013 |
20130046481 | Dual-Spectrum Heat Pattern Separation Algorithm For Assessing Chemotherapy Treatment Response And Early Detection - It is developed a Dual-Spectrum Heat Pattern Separation (DS-HPS) algorithm to quantify the energy from the area of the high temperature tissues, called q | 02-21-2013 |
20130054148 | INTERPRETATION - An improved method of comparing a first data set with a second data set is provided, particularly suited for data sets arising from the analysis of DNA samples, in which both first and second data set are compared with one another, the comparison occurring before any processing of the data has occurred. In this way an empirical analysis of the data is provided which does not introduce any of the errors or data omissions inherent in an interpretive approach to data analysis. | 02-28-2013 |
20130054149 | SYSTEM AND METHOD FOR ABSOLUTE QUANTIFICATION OF PROTEINS USING LC/MS - Absolute quantitation of protein in a sample is provided by comparing a sum or average of the N highest ionization intensities observed for peptides of a particular protein along with a calibration standard. The calibration standard can be in the form of a table generated by prior protein peptide analysis performed using one or more pre-determined proteins. The comparison is used to determine a corresponding absolute quantity of protein based on the observed sum or average of ionization intensities. A simple conversion factor can be applied to the calibration standard value to determine the absolute quantity of protein in the sample. | 02-28-2013 |
20130054150 | SYSTEM FOR TRACKING FEMALE FERTILITY - Described herein are various principles related to collecting and charting fertility data for a female (e.g., female humans). A dedicated device may be used to collect fertility data regarding the female. The device may include a thermometer for collecting a body temperature of the female as well as an interface for collecting data regarding a consistency and/or amount of a cervical fluid of the female. Once collected by the dedicated device, the fertility data may be transmitted wirelessly from the dedicated device via a wireless network (e.g., a wireless local area network) to a server that collects fertility data. The fertility data may then be displayed in a graph that enables a user to make determinations about a fertility cycle of the female, including determinations about times of high fertility. For example, from viewing the relationship between two lines included in the graph, the user may make determinations regarding fertility. | 02-28-2013 |
20130060477 | SYSTEMS AND METHODS FOR TOPOGRAPHIC ANALYSIS - The systems and methods described herein provide a scientific and analytical basis for the following: (a) collective interpretation of the entire spectrum of chromatographic data, e.g., GC×GC two-dimensional data, with capability of operating at multi-resolution over bigger or smaller sub-regions of the two-dimensional data, (b) given two or more samples that are from the same source, and some samples from clearly different sources, quantitatively estimate where the fingerprint of the source lies, (c) given a source signature template, an unknown sample can be compared to decide whether it is related to, and if so, to what degree, to this source, and (d) given two source signature templates, the templates can be compared to determine how related is one source to the other. | 03-07-2013 |
20130060478 | VOLTAGE OFFSET CORRECTION IN HIGH-THROUGHPUT ELECTROPHYSIOLOGICAL MEASUREMENT SYSTEM - A computer-implemented method for controlling command voltages applied to electrodes during an electrophysiology measurement procedure using a high-throughput measurement system is provided. An initial command voltage is applied to the electrodes to obtain baseline currents respectively associated with the electrodes. A common offset voltage is determined based on the baseline currents, and an adjusted command voltage is determined based on the initial command voltage and the common offset voltage. The adjusted command voltage is applied to at least one of the electrodes to obtain an adjusted current measured by the electrode. A local offset voltage for the electrode is determined based on the adjusted current measured by the electrode. A subsequent command voltage applied to the electrode incorporates the common offset voltage and the local offset voltage. | 03-07-2013 |
20130060479 | METHOD AND SYSTEM FOR GENOTYPING SAMPLES IN A NORMALIZED ALLELIC SPACE - Aspects of the present invention describe an apparatus and method for generating genotype calls for a sample. The genotyping initially models allelic signal response into an allelic model having one or more model parameters for an identified one or more sources of systematic variation. The model and parameters are then used to transform the allelic signals to a normalized normalized allelic space that serves to compensate for the one or more sources of systematic variation. By compensating for the systematic variation in this manner, the genotype for the sample is readily determined based upon its relationship to the representation of the allelic signals in normalized allelic space and in accordance with the allelic model. | 03-07-2013 |
20130060480 | METHOD AND APPARATUS FOR PROVIDING ADAPTIVE DISPLAY AND FILTERING OF SENSORS AND SENSOR DATA - An approach is provided for adaptive display and filtering of sensors and sensor data. A sensor manager determines one or more signals associated with one or more sensors. The sensor manager then processes and/or facilitates a processing of the one or more signals for comparison against one or more predetermined signals. The sensor manager determines one or more parameters for one or more filters based, at least in part, on the comparison, wherein the one or more filters operate, at least in part, on the one or more sensors, one or more other signals determined form the one or more sensors, or a combination thereof. | 03-07-2013 |
20130066562 | IN-VITRO DIAGNOSTIC DEVICE USING EXTERNAL INFORMATION IN CONJUNCTION WITH TEST RESULTS - A system and method for augmenting or adding to the information used by an in-vitro diagnostic or other diagnostic device to generate results of a test is disclosed. A diagnostic device is capable of generating test results based on a sample, such as a sample provided by a patient, and is also capable of receiving additional information to enhance the results providable by the device. For example, an in-vitro diagnostic device is configured to read a lateral flow assay test, and is configured to receive additional diagnostic, network, test identification, or environmental information over a network. Using both the result of the diagnostic test and the additional information, the disclosed device provides more thorough, accurate, and reliable diagnostic information. The results generated by the device may be communicated to an appropriate remote device to enhance the results obtainable by such tests. | 03-14-2013 |
20130066563 | DISTRIBUTED NETWORK OF IN-VITRO DIAGNOSTIC DEVICES - A system is disclosed in which a plurality of in-vitro diagnostic (IVD) devices each include a network communication device for connecting to a publicly accessible data network. For example, IVD devices are provided with a cellular modern for connecting to a public cellular network. These IVD devices connect to the data network upon completion of a diagnostic test, and upload results of the test, as well as other appropriate data, to a remote device which is also on the network. The IVD devices also download appropriate data from remote network elements. The remote network element may be a network element such as a Hospital Information System (HIS) or Laboratory Information System (LIS) database. Alternatively, the remote device may be a remote server or another IVD device. This connectivity enables the system to accumulate diagnostic test data, and to analyze, report, and/or update the IVD devices based on the accumulated data. | 03-14-2013 |
20130073211 | MICROCONTROLLER BASED PEDIATRIC DEVICE AND METHOD OF NOURISHMENT EVALUATION - A microcontroller based breast milk flow meter and child milk volume intake detection and measuring method means comprising a silicone encapsulated flexible microcontroller circuit means with a plurality of on-board dielectric detector plate means and a piezo-resistive force sensor means. Where the dielectric detector plates function electrically, as a passive device means to determine the presence or absence of a quantity of milk in a holding chamber means and a piezo-resistive force sensor function electrically, as a passive device means to determine a continuous or sporadic flow quantity of milk from said chamber means. A special microcontroller algorithm is used to monitor, detect, and measure breast milk flow and quantity from mother to child. | 03-21-2013 |
20130073212 | DETECTION OF RISK OF PRE-ECLAMPSIA - A method for the early prediction of risk of hypertensive disorders in pregnant women, including for example eclampsia, mild pre-eclampsia, chronic hypertension, EPH gestosis, gestational hypertension, superimposed pre-eclampsia, HELLP syndrome, or nephropathy. | 03-21-2013 |
20130073213 | Gene Expression-Based Differential Diagnostic Model for Rheumatoid Arthritis - Biomarkers useful for differential diagnosis for rheumatoid arthritis from samples of peripheral blood mononuclear cells are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. | 03-21-2013 |
20130073214 | SYSTEMS AND METHODS FOR IDENTIFYING SEQUENCE VARIATION - Systems and method for determining variants can receive mapped reads, and call variants. In embodiments, flow space information for the reads can be aligned to a flow space representation of a corresponding portion of the reference. Reads spanning a position with a potential variant can be grouped and a score can be calculated for the variant. Based on the scores, a list of probable variants can be provided. In various embodiments, low frequency variants can be identified where multiple potential variants are present at a position. | 03-21-2013 |
20130073215 | Heart Age Assessment - An automated method of determining a measure of a subject's heart age comprising the steps of: prompting a user for a plurality of inputs, each relating to an attribute of the subject, each attribute defining one or more of a demographic status of the subject, a lifestyle status of the subject, a physical condition of the subject and a medical history of the subject: receiving, from the user, a plurality of said inputs: determining from said received inputs, a set of parameters for which input data has been received as input from the user; selecting a heart age calculation algorithm from a predetermined set of heart age calculation algorithms according to said set of parameters; and calculating a heart age for the subject according to the selected algorithm; and providing as output said calculated heart age. | 03-21-2013 |
20130080068 | Phased Whole Genome Genetic Risk In A Family Quartet - An embodiment of the present invention is a methodology for prioritizing variants relevant to inherited Mendelian (“single gene”) disease syndromes according to disease phenotype, gene, and variant level information. | 03-28-2013 |
20130080069 | Method to Estimate Likelihood of Pathogenicity of Synonymous and Non-coding Variants Across a Genome - A method according to an embodiment of the present invention determines putative changes in splicing, mRNA structure, and protein synthesis. For each of these concepts, scoring algorithms are disclosed that can be used in a genome-wide scale. The described methods provide a pipeline that can be used to analyze the biological effects of SNPs generally, both synonymous and non-synonymous. | 03-28-2013 |
20130080070 | CHEMOMETRICS FOR NEAR INFRARED SPECTRAL ANALYSIS - This disclosure concerns systems and methods for identifying and selecting a more accurate chemometric model for the analysis of specific plant samples via near infrared spectrometry. This disclosure further concerns the use of such systems and methods to identify characteristics and traits of interest in plants and plant samples, for example, to facilitate selective breeding, quality control, and/or inventory control. | 03-28-2013 |
20130085677 | TECHNIQUES FOR IMPROVED PEDOMETER READINGS - Techniques are provided for improving pedometer readings. In some embodiments, motion data, such as acceleration data is detected, and a magnitude of the acceleration data, referred to as the modulus, is processed. The modulus is used to detect walking steps and running steps during a measurement. In some embodiments, a distance ran is calculated based on the detected running steps and an estimated running stride length, and a distance walked is calculated based on the detected walking steps and an estimated walking stride length. The estimated running and walking stride lengths are calculated based on various parameters associated with the acceleration data, population data, and user-specific data. Expended calories may be estimated based on the distance ran and walked. The distance analysis process further includes calibration techniques, including, for example, least squares simple regression, least squares multiple regression, and K-factor analysis. | 04-04-2013 |
20130085678 | METHODS AND SYSTEMS FOR COMPARING MEDIA CONTENT - Avatars, methods, apparatuses, computer program products, devices and systems are described that carry out presenting to at least one member of a population a plurality of avatars associated with at least one instance of media content; measuring at least one physiologic activity of the at least one member of the population, the at least one physiologic activity proximate to at least one presented avatar among the plurality of avatars associated with at least one instance of media content; associating the at least one physiologic activity with at least one mental state; and identifying at least one instance of media content based on the at least one mental state. | 04-04-2013 |
20130085679 | Methods, Devices and Systems for Analyte Monitoring Management - Methods of analyte monitoring management are provided. The methods include indicating on a user interface a plurality of analyte management procedures available for user-selection, where the plurality of analyte management procedures relate to analyte management parameters. Embodiments include receiving an indication to initiate a first procedure of the plurality of analyte management procedures, where the first procedure is for determining a first analyte management parameter. The methods may further include outputting user-instructions associated with the first procedure; receiving analyte measurement data for the first procedure; estimating the first analyte management parameter based on the analyte measurement data; calculating a degree of certainty for the estimation of the first analyte management parameter; and, initiating an action in response to an event associated with a status of the estimation of the first analyte management parameter or the degree of certainty. Analyte monitoring devices and systems implementing the methods are also provided. | 04-04-2013 |
20130085680 | System, Apparatus and Method for Evaluating Samples or Analytes Using a Point-of-Care Device - A system, apparatus and method evaluates samples or analytes using a point-of-care device. A test selection is received from the user interface. A determination is made whether a test cartridge connected to the test cartridge interface matches the test selection. Properties of the sample or the analyte are detected using detector(s) or sensor(s) in the POC device. A test results data based on the properties is generated. A report based on an analysis of the test results data is generated and the report is provided to the user interface of the POC device. The POC device also includes memory, communication interface(s), test cartridge interface, and processor(s). | 04-04-2013 |
20130085681 | METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS - Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations. | 04-04-2013 |
20130090859 | METHODS AND SYSTEMS FOR GENOME-SCALE KINETIC MODELING - Embodiments of the present invention generally relate to the construction, analysis, and characterization of dynamical states of biological networks at the cellular level. Methods are provided for analyzing the dynamical states by constructing matrices using high-throughput data types, such as fluxomic, metabolomic, and proteomic data. Some embodiments relate to an individual, while others relate to a plurality of individuals. | 04-11-2013 |
20130096836 | AUTOMATED TOTAL BODY ALBUMIN ANALYZER - A computer-based method for automatically determining total body albumin of a living being based on the calculated intravascular albumin, the calculated observed ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time, and the baseline of expected ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time. | 04-18-2013 |
20130096837 | AUTOMATED BLOOD ANALYZER - An automated blood analyzer that analyzes blood of a living being including one or more sample carriers that hold samples of blood of a living being, each sample having been withdrawn from the living being at a different point in time after the living being was injected with radio-labeled albumin, means for calculating a set of data points representing blood volume of the living being at the one or more points in time after the living being was injected with the radio-labeled albumin based on detected counts of the radio-labeled albumin in the samples of blood, wherein the automated blood analyzer uses the set of data points for further analysis of the blood of the living being, and a quality control module that at least one of calibrates the means for calculating or verifies that the means for calculating operates within predetermined parameters. | 04-18-2013 |
20130096838 | Gene Splicing Defects - Predicting the effect of a mutation in a nucleic acid sequence on splicing is accomplished by determining the distance between at least two nucleic acid sequence positional distributions and providing a prediction of impact on splicing function based on at least the distance. A low distance indicates there is little or no difference in splicing function compared to a normal control. A high distance indicates a difference in splicing function. Related apparatus, systems, techniques and articles are also described. | 04-18-2013 |
20130096839 | SEIZURE DETECTION METHODS, APPARATUS, AND SYSTEMS USING A WAVELET TRANSFORM MAXIMUM MODULUS ALGORITHM - Methods for detecting a seizure, by use of a wavelet transform maximum modulus (WTMM) algorithm applied to body data. A non-transitive, computer-readable storage device for storing data that when executed by a processor, perform such a method. | 04-18-2013 |
20130096840 | SEIZURE DETECTION METHODS, APPARATUS, AND SYSTEMS USING AN AUTOREGRESSION ALGORITHM - A method, comprising receiving a time series of patient body signal, determining first and second sliding time windows for the time series; applying an autoregression algorithm, comprising: applying an autoregression analysis to each of the first and second windows, yielding autoregression coefficients and a residual variance for each window; estimating a parameter vector for each window based on the autoregression coefficients and residual variances; and determining a difference between the parameter vectors; and determining seizure onset and seizure termination based on the difference between the parameter vectors. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method. | 04-18-2013 |
20130096841 | IDENTIFICATION OF DNA FRAGMENTS AND STRUCTURAL VARIATIONS - Various short reads can be grouped and identified as coming from a same long DNA fragment (e.g., by using wells with a relatively low-concentration of DNA). A histogram of the genomic coverage of a group of short reads can provide the edges of the corresponding long fragment (pulse). The knowledge of these pulses can provide an ability to determine the haploid genome and to identify structural variations. | 04-18-2013 |
20130096842 | GLUCOSE TOLERANCE ANALYZER, GLUCOSE TOLERANCE ANALYZING SYSTEM, AND STORAGE MEDIUM - A glucose tolerance analyzer comprising: an accepting section configured to accept inputs of information regarding a type of food or drink ingested by a subject, information regarding an intake amount of the food or drink, and information regarding an amount of glucose in the subject after the ingestion of the food or drink; an output section configured to output an analysis result of glucose tolerance; and a controller configured to: calculate a reference value for analyzing glucose tolerance of the subject based on the accepted information regarding the type of the food or drink ingested by the subject and the information regarding the intake amount of the food or drink, and based on a predetermined index regarding blood glucose increase due to food or drink; analyze the glucose tolerance of the subject based on the accepted information regarding the amount of glucose and based on the calculated reference value; and control the output section to output an obtained analysis result as an analysis result of glucose tolerance. | 04-18-2013 |
20130096843 | Portable Monitoring Devices and Methods of Operating Same - A portable activity monitoring device comprising a housing having a physical size and shape that is adapted to couple to the user's body, a motion sensor to detect user motion and, in response thereto, to generate data which is representative of motion of the user, an altitude sensor to detect a change in user altitude and, in response thereto, to generate data which is representative of the change in altitude of the user, processing circuitry to calculate activity metrics of the user, wherein the processing circuitry: (i) calculates a motion metric using the motion data, (ii) calculates an altitude metric using the altitude data, and (iii) calculates at least one sleep metric of the user. In certain embodiments, the processing circuitry may automatically determine a sleep mode of the user using the motion data and calculate at least one user sleep metric. | 04-18-2013 |
20130096844 | DETECTION OF CONDITIONS FROM SOUND - Disclosed are various systems, methods, and programs embodied in a computer-readable medium for sound analysis. The sound analysis involves transforming a sound print into a frequency domain in a memory to generate a frequency spectrum. A plurality of signatures are identified in the frequency spectrum. Also, a plurality of frequency ranges associated with the signatures are identified in the sound print. The frequencies associated with a physiological profile are cross-referenced with the frequency ranges to determine if the physiological profile is applicable to the sound print. | 04-18-2013 |
20130103320 | METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS - Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations. | 04-25-2013 |
20130103321 | Selection of Preferred Sample Handling and Processing Protocol for Identification of Disease Biomarkers and Sample Quality Assessment - The subject invention relates to methods for obtaining biological samples of improved quality. It encompasses the identification of markers or proteins in biological samples that are altered due to variations in sample collection, handling and processing. They are also useful for correcting variations in measured results for disease biomarkers. Further, they can permit the rejection of samples or groups of samples as necessary if it is determined that their collection method was not in accordance with the predetermined protocol. Other advantages useful to the skilled artisan are described herein. | 04-25-2013 |
20130110405 | METHOD AND APPARATUS FOR MEASURING HEMATOCRIT | 05-02-2013 |
20130110406 | METHOD AND APPARATUS FOR DISPLAYING ANALYSIS RESULT OF MEDICAL MEASURED DATA | 05-02-2013 |
20130110407 | DETERMINING VARIANTS IN GENOME OF A HETEROGENEOUS SAMPLE | 05-02-2013 |
20130110408 | METHODS FOR THE DIAGNOSIS OF DEMENTIA AND OTHER NEUROLOGICAL DISORDERS | 05-02-2013 |
20130110409 | BIOLOGICAL INFORMATION PROCESSING METHOD AND DEVICE, RECORDING MEDIUM AND PROGRAM | 05-02-2013 |
20130116929 | SYSTEMS AND METHODS FOR STIMULATION-RELATED VOLUME ANALYSIS, CREATION, AND SHARING - A computer implemented system and method facilitates a cycle of generation, sharing, and refinement of volumes related to stimulation of anatomical tissue, such as brain or spinal cord stimulation. Such volumes can include target stimulation volumes, side effect volumes, and volumes of estimated activation. A computer system and method also facilitates analysis of groups of volumes, including analysis of differences and/or commonalities between different groups of volumes. | 05-09-2013 |
20130116930 | Method and System for Assessment of Regulatory Variants in a Genome - The present invention provides methods embodied in a system that can be applied to genetic information comprising an individual genome to assess the regulatory impact of specific genetic variants and their possible impact on biological function or disease pathology. | 05-09-2013 |
20130116931 | Method and System for the Use of Biomarkers for Regulatory Dysfunction in Disease - Measuring of the binding of a transcription factor (using, for example, chromatin immunoprecipitation) according to the present invention is provides an improved marker for a disease. These markers can be used in diagnostics for diseases where a transcription factor binding event plays a role. Additionally, they can be used to adjust disease risk profiles for healthy individuals as with typical genetic variants. | 05-09-2013 |
20130124098 | Body Self-Shielding Background Compensation for Contamination Monitors Based on Anthropometrics - A system and method for correcting, based on a monitored subject's height and thickness, the net count rate value of a whole-body surface contamination monitoring device. The device includes a height detection means for determining the height of a subject being monitored, and a thickness detection means for determining the thickness of at least a portion of the body of the subject being monitored. The net count rate is based on site calibration factor data and self-shielding factor data, wherein both types of factor data consider the determined height and thickness. | 05-16-2013 |
20130124099 | SECONDARY STRUCTURE DEFINING DATABASE AND METHODS FOR DETERMINING IDENTITY AND GEOGRAPHIC ORIGIN OF AN UNKNOWN BIOAGENT THEREBY - The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity. | 05-16-2013 |
20130131992 | SYSTEM FOR MAGNETIC RESONANCE SPECTROSCOPY OF BRAIN TISSUE FOR PATTERN-BASED DIAGNOSTICS - A system and method for preprocessing magnetic resonance spectroscopy (MRS) data of brain tissue for pattern-based diagnostics is disclosed. The MRS preprocessing system includes an MRS preprocessing module that executes an operation that normalizes MRS spectrum data, recalibrates and scales the normalized MRS spectrum data, and then renormalizes the scaled MRS spectrum data. The resulting preprocessed MRS data is used to assist in identifying abnormalities in tissues shown in MRS scans. | 05-23-2013 |
20130131993 | ITERATIVE TIME SERIES MATRIX PATTERN ENHANCER PROCESSOR - A method and system for analyzing data about a physiological occurrence is described herein. The method includes executing a first software element to produce a result set with physiological data related to a set of patients. The method also includes detecting a physiological occurrence within the result set. Furthermore, the method includes generating a second software element to increase the accuracy of the first software element based on the physiological occurrence and the physiological data from the set of patients. | 05-23-2013 |
20130131994 | METHOD AND APPARATUS FOR MOBILE DISASTER VICTIM IDENTIFICATION - Mobile telecommunications or personal computing apparatus may be specially programmed for predicting whether an unknown biological specimen of an individual to be identified originates from or is related to a member of a particular family. The apparatus may comprise an input device including a barcode reader and a virtual touch screen keyboard whereby DNA profile or mass spectrometry test data may be entered among other data for an individual to be identified, for example, a missing person, victim, crime perpetrator or other unknown individual in hypothetical relationship to another individual or to a family pedigree of typed family members. The typed family pedigree in relation to the individual to be identified in hypothetical relation may be displayed on an output display of the apparatus including at least two different profile typing indicators for each displayed member of the pedigree. | 05-23-2013 |
20130138352 | SYSTEM AND METHOD FOR DETERMINING A BASELINE MEASUREMENT FOR A BIOLOGICAL RESPONSE CURVE - A system for determining a baseline measurement for a biological curve is provided. A derivation module determines a derivative response curve based on the biological response curve. A peak identification module searches the derivate response curve to identify a peak in the biological response curve. A leading baseline identification module searches the derivative response curve to identify a starting position of the peak and identifies a leading baseline in the biological response curve. The leading baseline is identified based at least in part on the starting position of the peak. A baseline determination module determines a baseline measurement for the biological response curve based at least in part on the leading baseline associated with the peak. | 05-30-2013 |
20130138353 | METHOD AND SYSTEM FOR DETECTING REGULATORY SINGLE NUCLEOTIDE POLYMORPHISMS - A computer-implemented method for detecting a regulatory single nucleotide polymorphism (rSNP). The method comprises determining a first score representative of a transcription factor binding affinity of a first allele, and a second score representative of a transcription factor binding affinity of a second allele. The first and second alleles are associated with a single nucleotide polymorphism (SNP), and the first score differs from the second score representing a change in the transcription factor binding affinity. A statistical significance value of the change in transcription factor binding affinity represented by the first score and the second score is then determined and compared with a threshold to determine whether the SNP is an rSNP. This disclosure also concerns a computer system and a computer program for detecting a regulatory single nucleotide polymorphism (rSNP). | 05-30-2013 |
20130138354 | ANALYSIS - A method of verifying the performance of a size standard, formed of a plurality of size standard elements, used in a nucleic acid analysis method is provided. The verification is achieved by introducing the size standard to an analysis stage and performing a size based separation on the size standard. The size based separation defines an experimental position for each size standard element. A comparison is made as to whether or not the experimental position for the size standard element corresponds with expected position. The comparison allows a decision to be made on whether or not to use the size standard, which is dependent upon whether or not the experimental position of the size standard element corresponds with the expected position. | 05-30-2013 |
20130138355 | METHOD AND SYSTEM FOR EVALUATING SEQUENCES - A method of evaluating correlation between sequences by employing a hierarchy of evaluation algorithms. The evaluation algorithms may be arranged in order of computational efficiency as specified by a user or as determined by the system. The algorithms may range from a simple equality algorithm through to seeded alignment algorithms etc. | 05-30-2013 |
20130138356 | Method And System For Detecting And Removing EEG Artifacts - A method and system for detecting and removing EEG artifacts is disclosed herein. Each source of a plurality of sources for an EEG signal is separated for a selected artifact type. Each source of the plurality of sources is reconstituted into a recorded montage and an optimal reference montage for recognizing the selected artifact type of each source. The sources with artifacts are removed and the remaining sources are reconstituted into a filtered montage for the EEG signal. | 05-30-2013 |
20130138357 | SYSTEMS AND METHODS FOR EVALUATING A PHYSIOLOGICAL CONDITION - A method and system are provided for evaluating in patient monitoring whether a signal is sensed optimally by receiving a signal, transforming the signal using a wavelet transform, generating a scalogram based at least in part on the transformed signal, identifying a pulse band in the scalogram, identifying a characteristic of the pulse band, determining, based on the characteristic of the pulse band, whether the signal is sensed optimally; and triggering an event. The characteristics of the pulse band and scalogram may be used to provide an indication of monitoring conditions. | 05-30-2013 |
20130144536 | Medical Device with Wireless Communication Bus - A medical device includes an internal wireless communication bus. The medical device comprises a first physiological sensor device comprising a first radio. The medical device further comprises a patient monitor device comprising a second radio. The medical device is configured to establish an internal wireless communication between the first radio and the second radio using the internal wireless communication bus. | 06-06-2013 |
20130144537 | Real Time Assessment During Interactive Activity - A solution for adjusting an interactive activity is provided. While a person is engaged in an instance of the interactive activity, direct measurement data corresponding to the person is received. The direct measurement data is used to assess at least one aspect of a response of the person to the instance of the interactive activity. Assessment data corresponding to the at least one aspect of the response is provided for use in adjusting at least one aspect of the interactive activity. | 06-06-2013 |
20130144538 | Clot Protection and Detection Algorithm for Activated Clotting Time Testing - Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots. | 06-06-2013 |
20130144539 | Embedded Data DNA Sequence Security System - An embedded data DNA sequence security system which utilizes an embedded data DNA sequence to differentiate each of a plurality of identifiable objects. | 06-06-2013 |
20130151162 | DRUG DELIVERY DEVICE - Drug delivery devices are described that include sensors and processing circuitry that can detect operating events, such as flow rates and drug delivery, in various types of inhalers, such as dry powder inhalers, metered dose inhalers, nasal inhalers and nebulisers. The information determined by the processing circuitry can be used to provide feedback to the user or can be stored or transmitted for subsequent analysis. This information can be used to improve clinical trials by providing information about the way in which the inhalers under test are being used. | 06-13-2013 |
20130151163 | METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW - Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. | 06-13-2013 |
20130151164 | Systems and Methods for Analyzing Microarrays - The present invention discloses methods and systems for analyzing microarray data. The method includes the general steps of providing microarray data, normalizing the data using a least trimmed squares regression, and then analyzing the normalized microarray data to obtain a desired result such as an expression profile. There is also disclosed a method of subdividing an array into subarrays before normalization. This approach provides a method for improving measurement accuracy and salvaging array data from arrays containing minor defects. Also disclosed is a Probe-Treatment-Reference (PTR) model for streamlining normalization and summarization of microarray data by allowing multiple references. Other aspects of the present invention include computer systems and computer readable media encoding methods of the present invention. | 06-13-2013 |
20130151165 | Computer Systems for Treating Diseases - The present invention relates to computer-implemented methods and system for analysing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analysing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling. | 06-13-2013 |
20130151166 | Reduction Of Classification Error Rates And Monitoring System Using An Artificial Class - Systems and methods for enhancing the accuracy of classifying a measurement by providing an artificial class. Seizure prediction systems may employ a classification system including an artificial class and a user interface for signaling uncertainty in classification when a measurement is classified in the artificial class. | 06-13-2013 |
20130158879 | METHODS AND APPARATUS FOR HARDWARE BASED RADIATION DOSE CALCULATION - Disclosed is an example method to calculate radiation dose. The method includes receiving a tissue matrix in which the tissue matrix includes a plurality of voxels. The example method also includes producing a first plurality of transport lines with a direction controller in which each transport line is indicative of a cone of irradiated energy, and calculating at least one radiation dose with at least one deposit engine substantially in parallel with producing a second plurality of transport lines with the direction controller. | 06-20-2013 |
20130158880 | Analysis of Community Structures in Environmental Samples - Systems and methods for analyzing community structures within a plurality of environmental samples are described herein. The method includes obtaining taxa data corresponding to taxonomic groups within the plurality of the environmental samples. Based on the taxa data, an abundance value for each of the taxonomic groups with respect to each of the plurality of environmental samples is determined. Further, based on abundance values, an interaction factor for each pair of the taxonomic groups in the plurality of environmental samples is computed. The interaction factor is indicative of a degree of interaction between a pair of taxonomic groups from among the taxonomic groups. Based in part on interaction factors and abundance values, the plurality of the environmental samples is clustered. | 06-20-2013 |
20130158881 | AUTONOMOUS MONITORING METHOD AND SYSTEM USING SENSORS OF DIFFERENT SENSITIVITIES - A method and system of monitoring for chemical or other toxic agents includes operating a plurality of first type sensors having a first level of sensitivity to an agent in a monitored area. Concurrently a second type sensor is operated having a second level of sensitivity to the agent in the monitored area, where the second level of sensitivity is at least ten times more sensitive than the first level of sensitivity. Input from the plurality of first type sensors and the second type sensor is received and analyzed, at a central location, in order to determine the presence of the agent in the monitored area. | 06-20-2013 |
20130158882 | METHOD OF FORMING MASS IMAGE - An object of the present invention is to provide a method of comprehensively visualizing a constituent in tumor tissue or the like at a cellular level. | 06-20-2013 |
20130158883 | INTENTION CONVEYANCE SUPPORT DEVICE AND METHOD - According to a conventional BMI technology for controlling external equipment or transmitting an intention to another person by focusing on a biosignal such as brain activity, there has been the problem that a large-sized apparatus is required, the operation method is complex from the user's viewpoint, and noise is large. The present invention provides an apparatus and method such that an intention in the brain can be analyzed with high accuracy and at high speed and transmitted in real-time. A communication assist apparatus according to the present invention comprises an apparatus for presenting a visual stimulus on a display screen and the like, and a processing apparatus for processing brain wave data from an electroencephalograph that measures a brain wave after stimulus presentation by the presenting apparatus. The processing apparatus determines that a specific intention decision has been made in the brain when the product of an accumulated discrimination score according to a discriminant analysis function obtained by analyzing the brain wave data and a success rate exceeds a threshold value, and then outputs a determination result to a device. | 06-20-2013 |
20130166217 | Method and Device for Fatigue Detection - In a method for detecting driver fatigue in a vehicle having a memory device in which a fatigue model is stored, a sensor which detects at least one activity of the driver, and a sensor which detects the ambient brightness, the activity information is analyzed in the fatigue model and the brightness information is used for weighting the model. | 06-27-2013 |
20130166218 | Methods And Systems For Sequence Alignment Computation - A system utilizes a Single Instruction Multiple Data (SIMD) processor to efficiently determine, in parallel, the optimal global alignment for multiple input sequence pairs. The system may partition a score matrix generated for the input sequence pair into multiple sectors. While determining the cell content for each of the cells in the score matrix, the system may selectively retain computed cell contents for upper and left boundary cells of the partitioned sectors. During a traceback process, the system may retrieve the retained boundary cells for a current sector and recompute the cell contents for the current sector. Then, the system may determine the traceback path for the current sector. The system may continue to process sectors one at a time until the traceback path for the score matrix, and accordingly the optimal global alignment for the input sequence pair, is determined. | 06-27-2013 |
20130166219 | SYSTEMS AND METHODS FOR MEDICAL DATA PROCESSING AND ANALYSIS - We describe a system/method for predicting the outcome of a medical procedure on a patient. The system/method uses using complement cascade data representing levels of a set of complement cascade markers in the patient at a succession of peri-operative time intervals, determining deviations from a model of the response to provide a pre-symptomatic prediction of the outcome. In embodiments the complement cascade pathways include the lytic pathway and at least one of the lectin pathway, the classical pathway and the alternative pathway, and the biomarkers include at least C3. The system may include an electroluminescence or plasmon-resonance multianalyte detector to analyse a blood sample from the patient. | 06-27-2013 |
20130166220 | TOOTHBRUSH USAGE MONITORING - The invention provides a system suitable for monitoring the usage of a toothbrush, the system comprising: (a) a toothbrush; (b) a sound sensor which is located in or on the toothbrush; (c) a programmable data logger which is located in or on the toothbrush, the data logger incorporating a motion sensor and a data store for the logging of data; (d) switching means for triggering the operation of the sound sensor in response to initial signals of toothbrush motion generated by the motion sensor, and (e) a data analysis device which is adapted to analyse data transmitted or acquired from the system to provide information about tooth brushing behaviour; in which the duration of data logging is controllable in response to the combined signals received from the sound sensor and the motion sensor respectively. | 06-27-2013 |
20130173170 | WEB-BASED PLATFORM FOR ANALYZING LARGE-SCALE TOF-SIMS DATA AND METHOD THEREOF - Disclosed is a web-based platform for analyzing large-scale TOF-SIMS data and a method thereof. The web-based platform for analyzing large-scale TOF-SIMS data according to the present invention comprises: a communication unit for providing a connected user terminal with a web page and receiving a file for analyzing the TOF-SIMS data from the user terminal via the provided web page; a processing unit for analyzing the TOF-SIMS data using the received file and providing the user terminal with information created based on a result of the analysis via the communication unit; and a storage unit for storing the information created based on the result of the analysis. Through the platform, the present invention may provide a web-based tool that can be used in an automated analysis method. | 07-04-2013 |
20130173171 | DATA-CAPABLE STRAPBAND - Embodiments relate to a band including sensors to detect motion and a motion matcher configured to capture data representative of the motion. The motion matcher can also identify an activity associated with the motion. The band transitions from one mode of operation to another as a function of the activity. Further, the band can include a controller and a memory storing data representing motion patterns. The controller is configured to select a mode of operation as a function of a motion pattern. | 07-04-2013 |
20130173172 | CONSIDERATION OF EVIDENCE - In many situations, particularly in forensic science, there is a need to consider one piece of evidence against one or more other pieces of evidence. For instance, it may be desirable to compare a sample collected from a crime scene with a sample collected from a person, with a view to linking the two by comparing the characteristics of their DNA, particularly by expressing the strength or likelihood of the comparison made, a so called likelihood ratio. The method provides a more accurate or robust method for establishing likelihood ratios through the definitions of the likelihood ratios used and the manner in which the probability distribution functions for use in establishing likelihood ratios are obtained. The methods provide due consideration of stutter and/or dropout of alleles in DNA analysis, as well as taking into consideration one or more peak imbalance effects, such as degradation, amplification efficiency, sampling effects and the like. | 07-04-2013 |
20130173173 | SYSTEMS AND METHODS FOR STEP DISCONTINUITY REMOVAL IN REAL-TIME PCR FLUORESCENCE DATA - Systems and methods for removing jump discontinuities in growth data are provided. A first approximation to a received data set is determined by applying a non-linear regression process to a non-linear function that models the data set to determine parameters, including a step discontinuity parameter. A second approximation to the data set is also determined by applying a regression process to a second non-linear function to determine parameters, including a step discontinuity parameter, of the second function. One of the approximations is selected based on an information coefficient determined for each of the approximations. If a confidence interval for the step discontinuity parameter includes zero, no correction is made, and if includes zero, then a correction is made. For a correction, the portion of the data curve prior to the step change is replaced with appropriate portion of the selected approximation to produce a shift-corrected data set. | 07-04-2013 |
20130173174 | APPARATUS, METHOD, AND SYSTEM FOR ACCURATE ESTIMATION OF TOTAL ENERGY EXPENDITURE IN DAILY ACTIVITIES - An apparatus, article, and system, the apparatus including a housing, a 3-axis accelerometer contained in the housing, a medium storing program instructions, and a processor to execute the program instructions stored in the memory to receive a signal from the 3-axis accelerometer indicative of a user's activities, extract features from the received signals, classify the extracted features into a plurality of activity types, determine a total energy expenditure based on the classification of the extracted features; and provide a report of the total energy expenditure. | 07-04-2013 |
20130173175 | METHOD AND APPARATUS FOR MEASURING BIOMETRICS OF OBJECT - A method for measuring biometrics of an object includes receiving an image of an object, modeling the object to identify a portion of the object, and measuring biometrics of the object based on a modeling result the object. | 07-04-2013 |
20130173176 | BIOLOGICAL SAMPLE MEASUREMENT SYSTEM - The present invention comprises a biological sample data management device ( | 07-04-2013 |
20130179084 | HAND-HELD TEST METER WITH SIGNAL RECOVERY BLOCK - A hand-held test meter (“HHTM”) for use with an analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing, an electrical signal receiving block, a signal recovery block and a microcontroller block, all of which are disposed in the housing. The electrical signal receiving block is configured to receive an electrical signal from an analytical test strip inserted in the HHTM that has been distorted into a distorted electrical signal. In addition, the signal recovery block and microcontroller block are configured to recover the electrical signal from the distorted electrical signal by generating a recovered electrical signal based on a predetermined recovered electrical signal frequency, a recovered electrical signal amplitude estimated from the distorted electrical signal, a recovered electrical signal offset estimated from distorted electrical signal and a recovered electrical signal phase determined using a least sum squares calculation. | 07-11-2013 |
20130179085 | PRECISION PHENOTYPING USING SCORE SPACE PROXIMITY ANALYSIS - Methods are provided for determining the level of perturbation of a phenotype in an organism using a multivariate statistical analysis. The method comprises a first step of collecting at least one measurement from at least one control group of organisms and at least one experimental group of organisms to produce a set of data. The method further comprises a second step of using a processor to conduct a multivariate statistical analysis on the set of data to determine the level of perturbation of a phenotype or trait of interest in the experimental group of organisms. Methods are further provided for selecting a group of organisms based on the multivariate statistical analysis. | 07-11-2013 |
20130179086 | SYSTEMS AND METHODS FOR THE DETERMINATION OF A COPY NUMBER OF A GENOMIC SEQUENCE - System and methods for the determination of a copy number of a target genomic sequence; either a target gene or genomic sequence of interest, in a biological sample are described. Various methods utilize a model drawn from a probability density function (PDF) for the assignment of a copy number of a target genomic sequence in a biological sample. Additionally, the methods provide for the determination of a confidence value for a copy number assigned to a sample based on attributes of the sample data. Additionally, various embodiments of an interactive graphical user interface (GUI) may provide an end-user with ready analysis of large sets of data representing a plurality of samples. In various embodiments of an interactive GUI, an end-user may be provided with a synchronized display of tabular and graphical sample data determined by an initial analysis according to a statistical model of a PDF. Such a synchronized display may enable an end-user to readily identify sample data for a subsequent analysis based on user input. | 07-11-2013 |
20130179087 | Methods and Systems for Determining, Monitoring, and Analyzing Personalized Response Variables Using Brain Wave Frequency Data and Interactive Multimedia Display - A computer-implemented method for monitoring one or more response variables in response to a media segment using brain wave frequency data includes displaying a media segment to a user. The media segment includes one or more embedded flags to flag one or more positions of the media segment. The method further includes acquiring brain wave frequency data of the user, acquiring amplitude data of the acquired brain wave frequency data in one or more frequency bands; and determining one or more response variables in response to the acquired amplitude data of the acquired brain wave frequency data correlating to flagged positions of the media segment. | 07-11-2013 |
20130179088 | SYSTEM AND METHOD FOR MEASURING RELATIVE LEG POSITIONS OF AN UNGULATE | 07-11-2013 |
20130184996 | DEVICE AND METHOD FOR INSULIN DOSING - A device and method of providing instruction to a patient regarding the dosing of insulin is provided. | 07-18-2013 |
20130184997 | Task-Modulated Neurobehavioral Status - Systems and methods for modulating a subject's neurobehavioral status by a task-dependent arousal index are provided. Neurobehavioral status may be measured or model-predicted, and the arousal index reflects the composite effect on the subject's neurobehavioral performance of behavioral, environmental, psychological, and physiological factors of the subject's performing an assigned task. Task arousal index may be selected from a database, provided by user input, or combined in real time from sensor data. | 07-18-2013 |
20130184998 | REPLICATION TIMING PROFILES FOR LEUKEMIA AND OTHER CANCERS - Described is a method for determining that a population of cells are a specific type of leukemic cell based on the replication timing fingerprint for the population of cells. | 07-18-2013 |
20130184999 | SYSTEMS AND METHODS FOR CANCER-SPECIFIC DRUG TARGETS AND BIOMARKERS DISCOVERY - The present invention provides users with cloud-based high throughput computing system for integrative analyses of next generation sequencing genomic data, such that human cancer biomarkers and drug targets can be accurately and quickly identified. Advantageously, the present invention harness a comprehensive systematic analysis pipelines for all types of next generation sequencing genomic data, advanced genomic variants calling algorithms and modeling, variant data correlation and integration, and identification of cancer specific biomarkers and therapeutic targets. Thus, the present invention will aid users so that less of their time and efforts are required in order to obtain precisely the desired information for which they are analyzing. | 07-18-2013 |
20130191032 | VERSION CONTROL FOR MEDICAL ANESTHESIA DEVICES - A testing system, a testing process, a medical device, e.g., an anesthesia device (G), and a computer program product are provided for testing installed program versions for acceptability. The anesthesia device (G) comprises a plurality of electronic components (K), which are operated and/or controlled with a program, which may have various versions. A release function ( | 07-25-2013 |
20130191033 | Analyzing spectra - Systems and methods for analyzing spectra are described. In analyzing the spectra, peaks are identified, and complexes and sub-complexes are assigned to their respective peaks. | 07-25-2013 |
20130191034 | ENERGY EXPENDITURE - Aspects relate to calculating energy expenditure values from an apparatus configured to be worn on an appendage of a user. Steps counts may be quantified, such as by detecting arm swings peaks and bounce peaks in motion data. A search range of acceleration frequencies related to an expected activity may be established. Frequencies of acceleration data within a search range may be analyzed to identify one or more peaks, such as a bounce peak and an arm swing peak. Novel systems and methods may determine whether to utilize the arm swing data, bounce data, and/or other data or portions of data to quantify steps. The number of peaks (and types of peaks) may be used to choose a step frequency and step magnitude. At least a portion of the motion data may be classified into an activity category based upon the quantification of steps. | 07-25-2013 |
20130191035 | METHOD AND SYSTEM FOR DETECTION AND REJECTION OF MOTION/NOISE ARTIFACTS IN PHYSIOLOGICAL MEASUREMENTS - Methods and systems for quantitatively detecting the presence of artifacts in physiological measurement data and for determining usable data among those that have been designated to be corrupted with artifacts are presented. | 07-25-2013 |
20130197811 | Method for Diagnosis of an Infectious Disease Stage and Determination of Treatment - The present invention relates to a means for determining if mammals within a group of mammals is affected by an infection that induces or could induce inflammation, if the mammal is likely to recover or not and if infected whether the mammal should be treated or let to recover untreated. By differentiating infected mammals in a group into different subsets representing differing stages of the progress of the disease the present invention teaches how to prognosticate with continuous data the outcome of a treatment/no treatment decision. | 08-01-2013 |
20130197812 | SYSTEMS AND METHODS FOR DETECTION OF CHROMOSOMAL GAINS AND LOSSES - A modified principal component analysis technique is described herein for analysis of relatively small data sets for the detection of chromosomal aneuploidies and/or microdeletions. Unlike analysis techniques for microarray studies, the present technique uses a modified principal component analysis that does not involve performing a covariance analysis. The methods, systems, and apparatus described herein allow for significant reduction of data noise in tests for the detection of chromosomal aneuploidies and/or microdeletions, leading to fewer inconclusive results. | 08-01-2013 |
20130204535 | VISUALIZING PREDICTED AFFECTIVE STATES OVER TIME - Described herein are various technologies pertaining to estimating affective states of a user by way of monitoring data streams output by sensors and user activity on a computing device. Models of valence, arousal, and engagement can be learned during a training phase, and such models can be employed to compute values that are indicative of valence, arousal, and engagement of a user in near-real time. A visualization that represents estimated affective states of a user over time is generated to facilitate user reflection. | 08-08-2013 |
20130204536 | METHODS OF KINOME ANALYSIS - Method for analyzing phosphorylation data of a plurality of peptides are provided, the method comprising obtaining one or more datasets, each dataset comprising a phosphorylation signal intensity for each replicate of the plurality of peptides for a sample; transforming the phosphorylation signal intensity of each replicate of the plurality of peptides using a variance stabilizing transformation to provide a variance stabilized signal intensity for each replicate of the plurality of peptides; and identifying one or more peptides of the plurality of peptides that is/are consistently phosphorylated or consistently unphosphorylated. | 08-08-2013 |
20130211728 | METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW - Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. | 08-15-2013 |
20130211729 | DATA ANALYSIS OF DNA SEQUENCES - Systems and methods for data analysis are provided. In one embodiment, a method for analysis is provided, including electronically receiving sequence data; electronically receiving one or more reference data sequences related to at least an expression vector; associating the sequence data with at least one of the reference data sequences to identify a transgene flanking sequence; searching a genome for one or more insertion sites of the transgene flanking sequence; and annotating the genome and the one or more insertion sites within the genome when one or more insertion sites are found in said searching step. | 08-15-2013 |
20130211730 | METHOD AND DEVICE FOR THE MEASUREMENT AND THE ELIMINATION OF SYSTEM CHANGES IN A DEVICE FOR THE TREATMENT OF BLOOD - The present invention relates to a method and a device for the measurement of pressure signals in a blood treatment system, whereby system changes can be identified and can be differentiated additionally reliably between system changes in blood flow direction and in transmembrane direction in order to enable a targeted action. | 08-15-2013 |
20130218473 | FREQUENCY SHIFT DETECTOR - A frequency shift detector includes a digital control unit, a digital/analog converter, a reagent concentration detecting circuit and a frequency difference generator, wherein the digital control unit includes a control circuit and a direct digital frequency synthesizer electrically connected with the control circuit, and the control circuit comprises a reset terminal and a pulse input terminal. The digital control unit proceeds with accurate concentration detection for various samples borne on the reagent concentration detecting circuit. | 08-22-2013 |
20130218474 | Benchmarks for Normal Cell Identification - Methods for determining a model that can characterize and distinguish normal cell from a diseased cell and methods for determining health or health-risk status of an individual based on a normal/health cell reference population of cells are described. | 08-22-2013 |
20130218475 | Computer Systems for Treating Diseases - The present invention relates to computer-implemented methods and system for analysing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analysing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling. | 08-22-2013 |
20130218476 | METHODS FOR THE ANALYSIS OF HIGH RESOLUTION MELT CURVE DATA - The present application provides for various embodiments of methods for the analysis of high resolution melt (HRM) curve data; where statistical assay variations in melt curve data may result from system noise in an analysis system. Such system noise may arise from various sources, such as the thermal non-uniformity of a thermocycler block in a thermal cycler apparatus, a detection system, etc. Additionally, various methods for the analysis of HRM curve data may provide an identification of a sample without the need for a user inputted information. | 08-22-2013 |
20130218477 | METHOD FOR EVALUATING THE QUANTITY OF METHANE PRODUCED BY A DAIRY RUMINANT - A method involves at least measuring the weight quantity of at least one fatty acid (AG), derived from de novo synthesis, in a sample of milk from said ruminant and evaluating said quantity of methane according to the following formula: CH4=a*(de novo AG)+y*(BH AG)+z. | 08-22-2013 |
20130226464 | DATA COLLECTION SYSTEM FOR AGGREGATING BIOLOGICALLY BASED MEASURES IN ASYNCHRONOUS GEOGRAPHICALLY DISTRIBUTED PUBLIC ENVIRONMENTS - The present invention relates to biologically and behaviorally based systems and methods for measuring audience response to a target stimulus. The systems and methods are deployable in multiple locations and may display stimuli based on location, target demographics, and combinations thereof. | 08-29-2013 |
20130226465 | PREDICTION OF HORIZONTALLY TRANSFERRED GENE - Method(s) and system(s) for identifying horizontally transferred genes are described herein. The method includes defining a cuboid in a three dimensional space, wherein the cuboid includes fragment points corresponding to the genomic fragments belonging to a plurality of sequenced microbial genomes, and dividing the cuboid into a plurality of grids. The method further includes selecting one or more grids corresponding to a selected genome and classifying each of the selected grids as one of majority, minority, and mixed grids, based on number of fragment points corresponding to the selected genome in each of the selected grids. Further, at least one genomic fragment from the minority and the mixed grids is identified as the horizontally transferred gene based on a distance ratio assessment. | 08-29-2013 |
20130226466 | QUERY SEQUENCE GENOTYPE OR SUBTYPE CLASSIFICATION METHOD - The present invention relates to a method for classifying genotype or subtype of query sequence. More particularly, the present invention is directed to a method for classifying genotype or subtype of query sequence, comprising: (i) selecting base sequences of various viruses of which genotypes or subtypes are known as reference sequences and obtaining a distance matrix by calculating distances between sequences in a multiple alignment of said reference sequences; and (ii) developing a discriminant equation which may classify the reference sequences by performing discriminant analysis for a cluster obtained by clustering said reference sequences through multidimensional scaling of the distance matrix, followed by classifying genotype or subtype of a query sequence according to said discriminant equation. | 08-29-2013 |
20130226467 | SYSTEM AND METHOD FOR PROCESSING REFERENCE SEQUENCE FOR ANALYZING GENOME SEQUENCE - Provided are systems and methods for processing a reference sequence. Exemplary systems for processing a reference sequence may include a seed extractor configured to extract a seed from a reference sequence; a determiner configured to determine whether an unidentified base is present or absent in a seed extracted by the seed extractor; and an index generator configured to add a seed to an index when unidentified bases are absent from an extracted seed. | 08-29-2013 |
20130226468 | GENOMIC FEATURES ASSOCIATED WITH EPIGENETIC CONTROL REGIONS AND TRANSGENERATIONAL INHERITANCE OF EPIMUTATIONS - CpG densities and sequence motifs that are characteristic of regions of DNA associated with epimutations and control of epimutations are provided. Such regions include, within approximately 400 (or fewer) base pairs, at least one, usually two, and preferably all three of the following features: i) a CpG density of 15% or less; ii) the presence of the sequence motif ATTTGTTTTTTCTTTTnT (SEQ ID NO: 1) where n is A, T, C or G, and statistically relevant variants thereof; and iii) the presence of the sequence motif GGGGGnGGGG (SEQ ID NO: 2), where n is A, T, C or G, and statistically relevant variants thereof. | 08-29-2013 |
20130231869 | APPARATUS FOR CANCER DIAGNOSIS - The present invention provides an apparatus for screening cancer, which reads low-mass ion mass spectrum for diagnosing cancer based on biostatistical analysis with respect to low-mass ions extracted from biological materials, and diagnoses cancer using the low-mass ion spectrum. An apparatus for cancer diagnosis, including a low-mass ion detecting unit which detects mass spectra of low-mass ions of biological materials; a cancer diagnosing unit which compares and analyzes patterns of mass spectra and diagnoses cancer; a display unit which displays cancer diagnosis information from the cancer diagnosing unit. | 09-05-2013 |
20130231870 | METHODS AND COMPUTER PROGRAM PRODUCTS FOR COMPRESSION OF SEQUENCING DATA - A compression method includes measuring a waveform associated with a chemical event occurring on a sensor array, wherein the waveform comprises at least one region associated with expected measured values and at least one region associated with unpredictable measured values; applying a first compression process to the waveform, the first compression process including an averaging of one or more frames in one or more portions of the waveform; and applying a second compression process to the waveform, the second compression process including a truncating of data corresponding to a portion of the waveform that is not related to a nucleotide incorporation component of the waveform. | 09-05-2013 |
20130231871 | MULTIFUNCTIONAL BREATH ANALYZER - A multifunctional breath analyzer includes a receptor unit for receiving a breath sample from a test subject, a sensing unit providing a signal corresponding to the concentration of at least one volatile substance within the sample, elements for providing a signal indicative of the dilution of the breath sample, and an analyzing unit/processing unit for the identification and quantification of the volatile substance of the breath sample. The signal processing unit is configured to perform at least two different calculations for the quantification, and the signal processing unit is also configured to automatically display the result of a selected calculation, the selection being based on the signal indicating dilution. | 09-05-2013 |
20130238250 | SYSTEM AND METHOD FOR PROCESSING GENOME SEQUENCE IN CONSIDERATION OF SEED LENGTH - Provided are systems and methods for processing a genome sequence by adjusting seed length. Exemplary systems for processing a genome sequence may include a seed extractor configured to extract a seed from a target sequence; and an index generator configured to index the seed extracted from the seed extractor. In some embodiments, the length of the seed extracted is adjusted based on the number of seeds extracted from the target sequence that have the same nucleotide sequence. | 09-12-2013 |
20130238251 | METHOD AND SYSTEM FOR DETECTING DISCRIMINATORY DATA PATTERNS IN MULTIPLE SETS OF DATA - A comprehensive analysis procedure for analyzing and comparing multiple sets of data to detect hidden discriminatory data patterns. The inventive procedure identifies a best subset of markers for optimal discrimination between two or more sets of data. A point-wise test on two or more sets of data is performed to calculate test statistic values and to generate a statgram, a two- or higher-dimensional map of the test statistic values along the range of data. A threshold is then determined for isolating critical regions of the statgram at each significance level to provide candidate markers. A subset of markers from the candidate markers is then selected to discriminate among the sets of data. The two or more sets of data are classified using the subset of markers. | 09-12-2013 |
20130245957 | Magnetic Resonance Spectroscopy of Breast Biopsy to Determine Pathology, Vascularization and Nodal Development - Robust classification methods analyse magnetic resonance spectroscopy (MRS) data (spectra) of fine needle aspirates taken from breast tumours. The resultant data when compared with the histopathology and clinical criteria provide computerized classification-based diagnosis and prognosis with a very high degree of accuracy and reliability. Diagnostic correlation performed between the spectra and standard synoptic pathology findings contain detail regarding the pathology (malignant versus benign), vascular invasion by the primary cancer and lymph node involvement of the excised axillary lymph nodes. The classification strategy consisted of three stages: pre-processing of MR magnitude spectra to identify optimal spectral regions, cross-validated Linear Discriminant Analysis, and classification aggregation via Computerised Consensus Diagnosis. Malignant tissue was distinguished from benign lesions with an overall accuracy of 93%. From the same spectrum, lymph node involvement was predicted with an accuracy of 95% and tumour vascularisation with an overall accuracy of 92%. | 09-19-2013 |
20130245958 | ACCURATE COMPARISON AND VALIDATION OF SINGLE NUCLEOTIDE VARIANTS - A method is disclosed for validation of single nucleotide variants (SNV) in a sequence of interest. In at least one embodiment, the method includes: interrogating a BAM-file of the sequence of interest and a reference sequence file and producing a summary table for genomic coordinates of interest; generating a plurality of sequence reads from a sample of said sequence of interest; filtering sequence reads using a plurality of filter levels; extracting SNV counts for each strand for a genomic region of interest within the sequence of interest, resulting in ten SNV counts; for each genomic region of interest determining a rule based genotype decision and inferring a best genotype from the 10 counts; and creating a single consensus file for said sequence of interest including information of best genotype and a best quality for each genomic region of interest. | 09-19-2013 |
20130245959 | Computer-Implementable Algorithm for Biomarker Discovery Using Bipartite Networks - An algorithm is disclosed for analyzing a bipartite network. The algorithm ( | 09-19-2013 |
20130245960 | METHODS OF NORMALIZING MEASURED DRUG CONCENTRATIONS AND TESTING FOR NON-COMPLIANCE WITH A DRUG TREATMENT REGIMEN - Methods for monitoring subject compliance with a prescribed treatment regimen are disclosed. In one embodiment, the method comprises measuring a drug level in fluid of a subject and normalizing said measured drug level as a function of one or more parameters associated with the subject. The normalized drug level is compared to a reference value and associated confidence intervals or to a concentration range. The reference value and associated confidence intervals and/or the concentration range may be normalized based on one or more parameters associated with subjects in a reference population. | 09-19-2013 |
20130253839 | SURPRISAL DATA REDUCTION OF GENETIC DATA FOR TRANSMISSION, STORAGE, AND ANALYSIS - A method, computer product, and computer system of reducing an amount of data representing a genetic sequence of an organism, comprising: a computer comparing nucleotides of the genetic sequence of the organism to nucleotides from a reference genome, to find differences where nucleotides of the genetic sequence of the organism which are different from the nucleotides of the reference genome; the computer using the differences to create and store surprisal data in a repository, the surprisal data comprising a starting location of the differences within the reference genome, and the nucleotides from the genetic sequence of the organism which are different from the nucleotides of the reference genome, discarding sequences of nucleotides that are the same in the genetic sequence of the organism and the reference genome. | 09-26-2013 |
20130253840 | PROCESSING TECHNIQUE FOR AN IMPEDANCE BIOSENSOR - A system for determining impedance includes receiving a time varying voltage signal from a biosensor and receiving a time varying current signal from the biosensor. The time varying voltage signal and the time varying current signal are transformed to a domain that represents complex impedance values. Calculating parameters based upon the impedance values in a manner suitable to automatically select a first endpoint of an analysis aperture in a region of interest. | 09-26-2013 |
20130253841 | ABSENTMINDED STATE DETERMINATION APPARATUS - An absentminded state determination apparatus includes: a data obtaining element for obtaining a time series data of a physiological characteristic value of a participant, wherein a fluctuation component is overlapped on the time series data, and depends on a state of the participant including normal and absentminded states; a detection element for detecting reflecting portions of the time series data, which reflect on the fluctuation component; a counting element for counting the number of the reflecting portions of the time series data in a determination time period between a determination time and a certain past time; and a determination element for determining according to the number of the reflecting portions at the determination time whether the participant is in the absentminded state. The determination time period has a predetermined time width from the certain past time to the determination time. | 09-26-2013 |
20130253842 | DIAGNOSIS OF LYMPHOID MALIGNANCIES AND MINIMAL RESIDUAL DISEASE DETECTION - Methods are described for diagnosis of a lymphoid hematological malignancy in a subject prior to treatment, and for detecting minimal residual disease (MRD) in the subject after treatment for the malignancy, by high throughput quantitative sequencing (HTS) of multiple unique adaptive immune receptor (TCR or Ig) encoding DNA molecules that have been amplified from DNA isolated from blood samples or other lymphoid cell-containing samples. Amplification employs oligonucleotide primer sets designed to amplify CDR3-encoding sequences within substantially all possible human VDJ or VJ combinations. Disease-characteristic adaptive immune receptor clonotypes occur, prior to treatment, at a relative frequency of at least 15-30% of rearranged receptor CDR3-encoding gene regions. Following treatment, persistence of at least one such clonotype at a detectable frequency of at least 10 | 09-26-2013 |
20130253843 | NON-RESISTIVE CONTACT ELECTRICAL SYSTEMS AND METHODS FOR VISUALIZING THE STRUCTURE AND FUNCTION OF OBJECTS OR SYSTEMS - Methods and systems for sensing properties of an object or entity utilize non-resistive contact sensors alone or in combination with other sensors. The sensor data is utilized for detecting and visualizing properties of one or more biological or non-biological objects or entities. | 09-26-2013 |
20130253844 | IDENTIFYING A DE NOVO FETAL MUTATION FROM A MATERNAL BIOLOGICAL SAMPLE - Systems, methods, and apparatus for determining at least a portion of fetal genome are provided. DNA fragments from a maternal sample (maternal and fetal DNA) can be analyzed to identify alleles at certain loci. The amounts of DNA fragments of the respective alleles at these loci can be analyzed together to determine relative amounts of the haplotypes for these loci and determine which haplotypes have been inherited from the parental genomes. Loci where the parents are a specific combination of homozygous and heterozygous can be analyzed to determine regions of the fetal genome. Reference haplotypes common in the population can be used along with the analysis of the DNA fragments of the maternal sample to determine the maternal and paternal genomes. Determination of mutations, a fractional fetal DNA concentration in a maternal sample, and a proportion of coverage of a sequencing of the maternal sample can also be provided. | 09-26-2013 |
20130253845 | PARTICLE BEAM THERAPY SYSTEM - The objective is to eliminate the effect of the hysteresis of a scanning electromagnet and resume high-accuracy beam irradiation from an irradiation position where it has been interrupted, even in the case where emergency-stop processing is performed during therapy. There are provided an irradiation management apparatus that controls a scanning electromagnet; and an interlock information inputting device that generates an interlock signal for stopping irradiation of the charged particle beam, when a contingency occurs. When irradiation of the charged particle beam is resumed, the irradiation management apparatus performs idle operation in which the scanning electromagnet is controlled, with the charged particle beam unirradiated, from a start step, which is situated prior to a stop step and is different from the initial step in actual irradiation, to the stop step, and then irradiates the charged particle beam from the desired irradiation position coordinates corresponding to the stop step. | 09-26-2013 |
20130253846 | Method and Apparatus for Providing Data Processing and Control in a Medical Communication System - Methods and apparatus for providing data processing and control for use in a medical communication system are provided. | 09-26-2013 |
20130261983 | METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS - Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations. | 10-03-2013 |
20130268203 | System and method for disease diagnosis through iterative discovery of symptoms using matrix based correlation engine - A system and method for disease diagnosis through iterative discovery of symptoms using matrix based correlation engine. The Dialog Manager uses the correlation engine to drive the dialogue with the user and presents optimum number of right questions based on which the system correlates and identifies probable disease (s) and the symptom (s) that has the maximum potential to narrow down the search, so as to reach a particular conclusion on disease type. The system computes the most probable disease based on the scores associated with various symptoms. The correlation engine is optimized by computing the probability of diseases using boost factor based on user profile, the total time lapsed from the onset of diseases etc. to enhance the accuracy of the disease identification. Based on the conclusions, Dialog Manager requests the Decision Support Engine for further suggestions and handles the subsequent interaction between the user and Decision Support Engine. | 10-10-2013 |
20130268204 | Invasive Chemometry - The invention relates to methods and devices for assessing one or more components of a selected tissue in an animal. The present invention permits non-invasive assessment of tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the tissue component for one or more regions that exhibit the optical characteristic of the tissue of interest. | 10-10-2013 |
20130268205 | Fitness Training System with Energy Expenditure Calculation That Uses a Form Factor - System and methods are provided for prompting a user to perform an exercise and to monitor the exercise. The form of the user may be monitored, such as with one or more video cameras and/or other sensors, to determine how well the user is performing the exercise. Energy expenditure is estimated based factors that include the type of the exercise, the form of the user and a contribution value that associates energy expenditure with form. | 10-10-2013 |
20130275048 | METHOD OF OPERATING USER INFORMATION-PROVIDING SERVER BASED ON USERS MOVING PATTERN AND EMOTION INFORMATION - The present invention relates to a method of analyzing user's behaviors based on a moving pattern of the user, and more particularly, to a method of operating a user information-providing server, in which behaviors of the user can be analyzed by providing information on user's emotion which varies depending on a moving pattern of the user, together with the moving pattern of the user, to the user or a counterpart. The inventive user information-providing server operating method provides information on user's emotion inferred using user's biological information obtained from a variety of sensors, information on a place where the user is positioned, and information on a counterpart, so that user's behaviors applicable to various fields can be accurately determined based on simple user's moving patterns and user information varying depending on the user's moving pattern. In addition, user's behaviors varying depending on the obtained counterpart information can be determined. | 10-17-2013 |
20130275049 | System and Method of Assessing Allergic Status in a Subject - A method of assessing the allergic status of a subject to a specific allergen, comprises the steps of determining a subject-specific numeric value for a plurality of variables comprising age, sex, SPT, IgE, (sIgE or tIgE minus sIgE) and allergic symptoms, applying an allergen-specific weighting to the numeric value for each variable, and correlating the weighted numeric values with allergic status for the subject. The weighted numeric values is correlated with allergenicity status using a deterministic probability function. | 10-17-2013 |
20130275050 | METHODS AND SYSTEMS FOR INTEGRATED HEALTH SYSTEMS - Methods, business methods, and systems are provided herein for integrated healthcare. As the amount of medical information increases rapidly, including information from multiple biomarkers, analysis and management of that information becomes more and more important to extract meaningful conclusions from the information. Statistical and computational methods are described herein that have been created for the methods and systems for integrated healthcare. For example, a computer system is described extracts significance over time of PSA and fPSA biomarker tests for prostate health. | 10-17-2013 |
20130275051 | COMPUTING DEVICE AND METHOD FOR DETECTING CELL DEATH IN A BIOLOGICAL SAMPLE - A computing device system and method for detecting cell death in a biological sample is provided. A plurality of optical coherence tomography (OCT) data sets are received, each representative of OCT backscatter data collected from the biological sample and comprising respective signal fluctuation as a function of time at different respective times over a given time period. Respective indications of respective signal decorrelation rates are determined for each of the plurality of OCT data sets at each of the different respective time. It is determined that cell death has occurred in the biological sample when the respective indications of respective signal decorrelation rates changes over the given time period | 10-17-2013 |
20130282293 | METHOD AND APPARATUS FOR IDENTIFYING PROTEINS IN MIXTURES - Protein identification in a complex sample begins by selecting a database having proteins likely to be in the sample. In-silico digestion is performed and a target peptide is selected from produced peptides. The masses of the Y- and B-ion fragments of the target peptide are determined. These masses are used to search previously obtained low- and high-energy AMRTs obtained from LC/MS analysis of the complex sample for masses on the list. Any mass observed in the data within a detection threshold are considered a hit. If enough hits accumulate in a given retention time, the target peptide is identified as being in the sample. The list of peptides identified in the complex sample can be used to identify the proteins present in the sample, track the chromatographic retention times of peptides between samples, and quantitate the peptides and proteins present in complex samples. | 10-24-2013 |
20130282294 | Methods and Systems for Processing Data - The present invention is directed to methods and systems for applications relating to correction of numerical data resulting from dynamic changes to a true value. Such methods and systems may be used in accurate and unbiased quantitative polymerase chain reaction measurement. | 10-24-2013 |
20130282295 | SYSTEM AND METHOD FOR CLASSIFYING RESPIRATORY AND OVERALL HEALTH STATUS OF AN ANIMAL - Systems and methods are provided for determining the respiratory and overall health status of an animal. The systems and methods utilize location data of individual animals to generate variables describing the behavior of the individual animals. The systems and methods evaluate the variables to assess the health status of individual animals. | 10-24-2013 |
20130282296 | LOW PERFUSION SIGNAL PROCESSING SYSTEMS AND METHODS - In some embodiments, systems and methods for identifying a low perfusion condition are provided by transforming a signal using a wavelet transform to generate a scalogram. A pulse band and adjacent marker regions in the scalogram are identified. Characteristics of the marker regions are used to detect the existence of a lower perfusion condition. If such a condition is detected, an event may be triggered, such as an alert or notification. | 10-24-2013 |
20130282297 | NOVEL METHODS FOR MEDICINAL DOSAGE DETERMINATION AND DIAGNOSIS - The present invention is directed to systems and methods for diagnosing tissue abnormality or diseases, determining effective drug dosages, and monitoring therapeutic drug treatments. The methods and systems described utilize tissue imaging in situ and computer modeling. | 10-24-2013 |
20130282298 | URINE ANALYZER AND URINE SAMPLE INFORMATION PROCESSING METHOD - A urine analyzer includes a controller configured to perform, when a qualitative measurement result of a sample is obtained and a sediment measurement result of the sample has been stored in a storage section, a cross-check of the obtained qualitative measurement result and the stored sediment measurement result, and to perform, when a sediment measurement result of a sample is obtained and a qualitative measurement result of the sample has been stored in the storage section, a cross-check of the obtained sediment measurement result and the stored qualitative measurement result. | 10-24-2013 |
20130282299 | Method and Device for Early Signal Attenuation Detection Using Blood Glucose Measurements - Methods and devices to detect analyte in body fluid are provided. Embodiments include receiving one or more analyte sensor data, receiving a reference measurement value associated with an analyte level, determining a sensitivity parameter based on the received one or more analyte sensor data and the reference measurement value, performing a probability analysis based on prior analyte sensor data to determine presence of signal attenuation, and generating an output value based on the probability analysis. | 10-24-2013 |
20130289882 | INTER-FRAME COMPLEX OCT DATA ANALYSIS TECHNIQUES - Techniques for collecting and processing complex OCT data to detect localized motion contrast information with enhanced accuracy and sensitivity are presented. In a preferred embodiment, vector differences between complex OCT signals taken at the same location on the sample are used to detect blood flow in the retina. Additional embodiments involving non-linear intensity weighting of the motion contrast information, normalization of the vector difference amplitudes, and calculating the absolute value of the standard deviation of Doppler signal are described. Image processing techniques to enhance the images resulting from these motion contrast techniques are also presented. | 10-31-2013 |
20130289883 | SYSTEM FOR OPTIMIZING A PATIENT'S INSULIN DOSAGE REGIMEN - A system for optimizing a patient's insulin dosage regimen over time, comprising at least a first memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen, and data inputs corresponding at least to the patient's blood-glucose-level measurements determined at a plurality of times, and a processor operatively connected to the at least first memory. The processor is programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components in the patient's present insulin dosage regimen in order to maintain the patient's future blood-glucose-level measurements within a predefined range. | 10-31-2013 |
20130289884 | PROTECTIVE HDL PARTICLE NUMBER EVALUATIONS - Embodiments of the invention are directed to improved discrimination of protective (anti-atherogenic) HDL from atherogenic or non-protective (NP) HDL. The methods, systems and computer program products determine protective high density lipoprotein particle (HDL-P) numbers. The methods include obtaining concentration measurements of at least twenty subpopulations of HDL-P subclasses in a blood plasma or serum sample and calculating a protective HDL-P number using (i) a defined subset of the obtained HDL-P concentration measurements or (ii) a zero or defined weighting factor below 1 for HDL-P concentration measurements for HDL subclasses associated with particle sizes above about 11 nm. | 10-31-2013 |
20130289885 | CHD RISK STRATIFICATION EVALUATIONS FOR SUBJECTS WITH HIGH LEVELS OF LARGE HDL -P - Embodiments of the invention are directed to methods, systems and computer programs that provide improved risk stratification for people having elevated large HDL-P using at least one defined HDL risk interaction parameter. | 10-31-2013 |
20130289886 | Calorie Monitoring System - Systems and methods for measuring calorie consumption and expenditure is disclosed. The system includes a peripheral device and a smart device. The peripheral device has one or more motion sensors and one or more weight sensors. The smart device is in electronic communication with the peripheral device and is configured to calculate calorie consumption and expenditure of a user based on data measured from the one or more motion sensors and one or more weight sensors. | 10-31-2013 |
20130289887 | Method for Characterizing a Sample by Data Analysis - The invention relates to a method for characterizing a sample, having the following steps: providing at least one analysis result having a plurality of values, wherein the analysis result was generated by the analysis of a sample by at least one analysis method; determining the value of at least one mathematic relation between at least two values of the plurality of values; generating a characterizing signature of the sample on the basis of the value of the at least one mathematic relation. The invention further relates to a method for characterizing a system in which method the preceding method is used. | 10-31-2013 |
20130289888 | ANALYSIS SYSTEM FOR ANALYZING BIOLOGICAL SAMPLES, METHODS, AND COMPUTER PROGRAM PRODUCT THEREOF - An analysis system for analyzing biological samples, such as body fluids, methods implemented by the analysis system, and a computer program product for implementing the analysis system are disclosed. The system may include first and second lab devices, at least one of the lab devices may have a user identification component for identifying a user, a device identification component for identifying the lab device, and an interface component for sending a user identifier of the identified user and a device identifier of the lab device. The system may include a server computer having a server interface component for receiving the user identifier and the device identifier, and a processing component for determining a step of a workflow to be executed by the identified user, wherein the server interface component is operable to send a signal being indicative of a determined workflow to the lab device identified by the device identifier. | 10-31-2013 |
20130289889 | Biometric Monitoring Device having a Body Weight Sensor, and Methods of Operating Same - A system comprising a biometric monitoring device including a housing including a platform to receive at least one foot of the user, a body weight sensor to generate body weight data, processing circuitry to calculate user weight data which corresponds to the user's weight, using the body weight data, and communication circuitry to: (a) receive user identification data which identifies the user or a portable activity monitoring device, and (b) transmit the user weight data to data storage associated with the user identification data. The system further includes the portable activity monitoring device including a housing having a physical size and shape that is adapted to couple to the user's body, a sensor to generate sensor data, and communication circuitry to receive physiologic data which is based on the user weight data, and processing circuitry to calculate activity data using the sensor data and physiologic data. | 10-31-2013 |
20130297216 | METHOD AND SYSTEM OF LONGITUDINAL DETECTION OF DEMENTIA THROUGH LEXICAL AND SYNTACTIC CHANGES IN WRITING - The present invention is a method and system for detecting linguistic markers as signs and indicators of mental illness, even prior to onset of symptoms of the mental illness. The linguistic markers may be detected in diachronic analyses of writing or speech samples. In particular, the present invention may identify lexical and syntactic changes in language due to mental illness. To recognize such changes the present invention may utilize complete, fully parsed texts or speech representing a number of measures. The identification of markers may provide a means of detecting mental illness early on based on a person's use of language. The language may be presented as spontaneous speech or writing, and may include samples of speech and/or writing occurring over time. | 11-07-2013 |
20130297217 | Devices, Systems, and Methods for Automated Data Collection - Embodiments disclosed herein relate to methods, devices, and computer systems thereof for automated data collection from a subject. In certain embodiments, one or more characteristics of a subject are sensed, and the subject is given a queue status indicator based on a comparison of the subject's one or more sensed characteristics with corresponding sensed characteristics from other subjects. In one embodiment, the subject is a healthcare worker and the system, methods, and devices are utilized to evaluate the overall health of the worker as part of the check-in process for work. | 11-07-2013 |
20130297218 | Devices, Systems, and Methods for Automated Data Collection - Embodiments disclosed herein relate to methods, devices, and computer systems thereof for automated data collection from a subject. In certain embodiments, one or more characteristics of a subject are sensed, and the subject is given a queue status indicator based on a comparison of the subject's one or more sensed characteristics with corresponding sensed characteristics from other subjects. In one embodiment, the subject is a healthcare worker and the system, methods, and devices are utilized to evaluate the overall health of the worker as part of the check-in process for work. | 11-07-2013 |
20130297219 | Devices, Systems, and Methods for Automated Data Collection - Embodiments disclosed herein relate to methods, devices, and computer systems thereof for automated data collection from a subject. In certain embodiments, one or more characteristics of a subject are sensed, and the subject is given a queue status indicator based on a comparison of the subject's one or more sensed characteristics with corresponding sensed characteristics from other subjects. In one embodiment, the subject is a healthcare worker and the system, methods, and devices are utilized to evaluate the overall health of the worker as part of the check-in process for work. | 11-07-2013 |
20130297220 | Portable Monitoring Devices and Methods of Operating Same - A portable activity monitoring device adapted to couple to a body of a user, the portable activity monitoring device comprising a housing having a physical size and shape that is adapted to couple to the user's body, (i) one or more motion sensors, disposed in the housing, to detect motion, and (ii) a user interface, disposed in the housing. The monitoring device further includes processing circuitry, disposed in the housing, to: (i) detect one or more user inputs to the user interface using data from at least one of the one or more motion sensors, (ii) calculate data which is representative of a progress toward a user activity goal using data from at least one the motion sensors, and (iii) generate display data which is representative of the progress toward the user activity goal in response to detecting the user input to the user interface. | 11-07-2013 |
20130304386 | RANDOM ESTIMATION IN POSITRON EMISSION TOMOGRAPHY WITH TANGENTIAL TIME-OF-FLIGHT MASK - A method of estimating random events in positron emission tomography list mode data, including obtaining time-of-flight (TOF) list mode count data that includes TOF information; converting the obtained TOF list mode count data into four-dimensional (4D) raw sinogram count data, without using the TOF information, wherein the 4D raw sinogram count data includes random count values; interpolating the 4D raw sinogram count data to generate 4D interpolated sinogram count data; low-pass filtering the 4D interpolated sinogram count data to remove noise; converting the low-pass filtered 4D interpolated sinogram count data into filtered 4D raw sinogram count data; and generating, by a processor, five-dimensional (5D) TOF raw sinogram count data from the filtered 4D raw sinogram count data by effectively applying a TOF mask filter to the filtered 4D raw sinogram count data. | 11-14-2013 |
20130304387 | METHOD AND APPARATUS FOR ANALYZING GENETIC INFORMATION OF ABNORMAL TISSUE - A method and apparatus for analyzing genetic information of abnormal tissue, the method and apparatus involving obtaining a first set of sequence data that includes one or more pieces of sequence data that are aligned in one or more single nucleotide polymorphism (SNP) sites from genetic samples of abnormal tissue; obtaining a second set of sequence data that includes one or more pieces of sequence data that are aligned in one or more SNP sites from genetic samples of normal tissue; analyzing, by a processing unit, a distribution of alleles in corresponding portions of the first set of sequence data and the second set of sequence data; and determining a contamination rate of a sample of a tissue by using a result of the analyzing. | 11-14-2013 |
20130304388 | CONDITION ANALYSIS - The present invention provides a method of determining a treatment program for a subject. The method includes obtaining subject data representing the subject's condition. The subject data is used together with a model of the condition, to determine system values representing the condition. These system values are then used to determining one or more trajectories representing the progression of the condition in accordance with the model. From this, it is possible to determine a treatment program in accordance with the determined trajectories. | 11-14-2013 |
20130304389 | Methods of Lag-Compensation for Analyte Measurements, and Devices Related Thereto - In some aspects, methods of lag compensation of analyte measurements are provided. Methods of lag-compensation are provided for analyte point measurements and/or for analyte rate-of-change measurements. The methods include receiving a series of uncompensated analyte measurements and determining parameter values for analyte point and/or rate-of-change estimates based on reference analyte measurements. The analyte rate-of-change estimate is based on a sum of a plurality of scaled rates-of-changes. The analyte point estimate is based on a sum of an analyte point and a sum of a plurality of scaled rates-of-changes. Devices related to the methods are also provided. | 11-14-2013 |
20130304390 | Systems and Methods for the Analysis of Proximity Binding Assay Data - A proximity binding assay (PBA) is performed on at least one test sample, at least one reference sample, a background sample, and one or more calibration samples using a thermal cycler instrument. Ct values are determined for at least one set of test sample data and at least one set of reference sample data. Background corrected Ct values are calculated using a corresponding value in a background sample data set. A linear range is determined for the background corrected Ct values as a function of sample quantity. A linear regression line is calculated for each linear range. One or more parameter values of an exponential model (EM) fold change formula are estimated from the one or more sets of calibration sample data. A target protein quantity and associated confidence interval are calculated using the linear regression lines and the EM fold change formula. | 11-14-2013 |
20130311101 | MINIMIZATION OF SURPRISAL DATA THROUGH APPLICATION OF HIERARCHY OF REFERENCE GENOMES - A method, computer product, and computer system of minimizing surprisal data comprising: at a source, reading and identifying characteristics of a genetic sequence of an organism; receiving an input of rank of at least two identified characteristics of the genetic sequence of the organism; generating a hierarchy of ranked, identified characteristics based on the rank of the at least two identified characteristics of the genetic sequence of the organism; comparing the hierarchy of ranked, identified characteristics to a repository of reference genomes; and if at least one reference genome from the repository matches the hierarchy of ranked, identified characteristics, comparing nucleotides of the genetic sequence of the organism to nucleotides from the at least one matched reference genome, to obtain differences and create surprisal data. | 11-21-2013 |
20130311102 | DIAGNOSTIC METHODS AND DEVICES FOR MONITORING CHRONIC GLYCEMIA - Computer apparatus, non-transitory computer readable media and methods for receiving daily vectors of measured blood glucose level values ordered by daily-defined time points over multiple days distributed over a predefined time period; calculating a vector average; calculating a chronic glycemia value based on the vector average modified by a universal term based on the centroid of an attractor basin; receiving subsequent daily vectors of blood glucose level values measured at subsequent defined time points after the predefined time period; calculating an updated vector average; calculating a subsequent chronic glycemia value based on the updated vector average modified by the universal term based on the centroid of the attractor basin estimated from the orbit; and outputting the chronic glycemia value and subsequent chronic glycemia value. | 11-21-2013 |
20130311103 | System and Method for Determining the Point of Hydration and Proper Time to Apply Potential to a Glucose Sensor - According to an embodiment of the invention, a method of determining hydration of a sensor having a plurality of electrodes is disclosed. In particular embodiments, the method couples a sensor electronics device to the sensor and measures the open circuit potential between at least two of the plurality of electrodes. Then, the open circuit potential measurement is compared to a predetermined value. In some embodiments, the plurality of electrodes includes a working electrode, a reference electrode, and a counter electrode. In still further embodiments, the open circuit potential between the working electrode and the reference electrode is measured. In other embodiments, the open circuit potential between the working electrode and the counter electrode is measured. In still other embodiments, the open circuit potential between the counter electrode and the reference electrode is measured. | 11-21-2013 |
20130311104 | CONTROL APPARATUS AND AUTHENTICATION METHOD - A blood pressure meter, a thermometer, and a pulse oximeter are connected to the control apparatus, and the control apparatus includes an input unit configured to wirelessly input information identifying a measurement time and unique information along with the measurement value from the measurement devices, a processing unit configured to store the inputted measurement value and unique information in a memory, and an authentication unit configured to authenticate the measurement device that inputted the measurement value as being the same as a measurement device that inputted a stored measurement value by comparing the unique information with unique information stored along with a measurement value measured prior to the inputted measurement value. Here, the processing unit is configured to store the inputted measurement value in the ease where the authentication succeeds. | 11-21-2013 |
20130317753 | System, Method, and Apparatus for Electronic Patient Care - A method implemented by an operative set of processor executable instructions configured for execution by a processor includes: determining if a monitoring client is connected to a base through a physical connection; establishing a first communications link between the monitoring client and the base through the physical connection; updating, if necessary, the interface program on the monitoring client and the base through the first communications link; establishing a second communications link between the monitoring client and the base using the first communications link; and communicating data from the base to the monitoring client using the second communications link. | 11-28-2013 |
20130317754 | MACHINE-IMPLEMENTED METHOD FOR ANALYZING GENOME-WIDE GENE EXPRESSION PROFILING - A machine-implemented method for analyzing a genome-wide gene expression profiling includes: searching at least one pathway database using genes in the genome-wide gene expression profiling as an index to find pathways; screening the pathways according to expression levels of the genes in the genome-wide gene expression profiling for identifying screened pathways that have statistical significance; establishing pathway sets according to the genes associated with the screened pathways; and determining biological information of the genes that are common to the screened pathways in the pathway set by making reference to correlation between the genes and gene ontology terms. | 11-28-2013 |
20130325352 | CALCULATION ENGINE BASED ON HISTOGRAMS - Methods and apparatus, including computer program products, are provided for processing analyte data. In some exemplary implementations, there is provided a method that includes generating, by at least one processor, a data structure comprising a plurality of bins assigned to a plurality of predetermined glucose concentration levels; generating, by the at least one processor, a value representative of a measured glucose concentration level obtained from received sensor data; adding, by the at least one processor, the value to at least one of the plurality of bins, wherein the adding of the value increments an occurrence value for the at least one of the plurality of bins; and analyzing, by the at least one processor, the data structure including the at least one of the plurality of bins and the occurrence value to determine at least one descriptive measurement. Related systems, methods, and articles of manufacture are also disclosed. | 12-05-2013 |
20130325353 | NMR QUANTIFICATION OF TMAO - A defined peak region residing between about 3.2 and 3.4 ppm of a proton NMR spectrum of an in vitro biosample is electronically evaluated to determine a level of trimethylamine-N-oxide (“TMAO”). The biosamples may be any suitable biosamples including human serum with a normal biologic range of between about 1-50 μM or urine with a normal biologic range of between about 0-1000 μM. | 12-05-2013 |
20130325354 | COMPUTERIZED METHOD FOR CORRELATING AND ELUCIDATING CHEMICAL STRUCTURES AND SUBSTRUCTURES USING MASS SPECTROMETRY - The present invention is directed to a computational method for correlating and elucidating a mass spectrum with one or more proposed chemical structures. | 12-05-2013 |
20130325355 | Multivariate Genetic Evaluation Of Maize For Grain Yield And Moisture Content - A method for genetic evaluation of an inbred plant includes construction of a phenotypic trait database incorporating at least two numerically representable phenotypic traits in a first plant population. Methods for selecting an inbred plant or hybrid plant based on genetic values can be obtained using a multivariate mixed model analysis of such a relationship matrix comprising at least two numerically representable phenotypic traits. | 12-05-2013 |
20130325356 | METHODS FOR DETERMINING HYDRATION OR DEHYDRATION LEVEL IN A SUBJECT - Methods for ascertaining a dehydration or hydration level in a subject are described. The methods comprise determining the concentration of a salivary indicator and, in some embodiments, assigning a hydration or dehydration level based on the salivary indicator concentration after mathematical transformation of the value and with regard to previously-determined, transformed baseline values or with regard to a correlation. | 12-05-2013 |
20130325357 | SYSTEM AND METHOD FOR WIRELESS, MOTION AND POSITION-SENSING, INTEGRATING RADIATION SENSOR FOR OCCUPATIONAL AND ENVIRONMENTAL DOSIMETRY - Described is a radiation dose calculation algorithm based upon the output of a radiation dosimeter including multiple sensor devices (including one or more passive integrating radiation sensors and optionally, a MEMS accelerometers, a wireless transmitters a GPS, a thermistor, or other chemical, biological or EMF sensors). The algorithm is used to convert the sensor output into dose values used to assess the exposure of personnel to ionizing radiation. Sensor output patterns are matched to stored empirically generated sensor outputs thru weighting and optimization calculation processes to determine personnel doses. Algorithm outputs can include personal dose equivalents, radiation types, radiation energy and radiation source identification. Dose calculations can be optimized for specific applications, and matched to different sets of measured data without changing the underlining software calculation programs. | 12-05-2013 |
20130325358 | ACTIVITY METER - A pedometer includes an activity amount acquisition unit that acquires an activity amount of a user, an index acquisition unit that acquires an index relating to the activity amount, and an index output unit that outputs the acquired index. The index acquisition unit includes an activity age acquisition unit that acquires an activity age represented by a standard age of a person who does the same amount of activity as the activity amount acquired in a unit period, using body information of the user, and acquires an index enabling the active age to reach a target activity age, based on the acquired activity amount. | 12-05-2013 |
20130325359 | HEMODYNAMIC STATUS ASSESSMENT - A patient-specific hemodyanmic status model is determined from impedance data collected during periods of normal and abnormal hemodynamic status by deriving parameter values of a set of multiple impedance-derivable parameters from impedance signals collected during periods of normal hemodynamic status and in connection with periods of abnormal hemodynamic status. The parameter values are employed to estimate coefficients of a linear parametric status model. These coefficients can then be used together with parameter values determined from impedance signals determined during status assessment periods in order to determine a current hemdoynamic status of the patient. | 12-05-2013 |
20130332081 | VARIANT ANNOTATION, ANALYSIS AND SELECTION TOOL - Disclosed are methods for detecting and/or prioritizing phenotype-causing genomic variants and related software tools. The methods include genomic feature based analysis and can combine variant frequency information with sequence characteristics such as amino acid substation. The methods disclosed are useful in any genomics study; for example, rare and common disease gene discovery, tumor growth mutation detection, personalized medicine, agricultural analysis, and centennial analysis. | 12-12-2013 |
20130332082 | MULTI-PARAMETER DIABETES RISK EVALUATIONS - Methods, systems and circuits evaluate a subject's risk of developing type 2 diabetes or developing or having prediabetes using at least one defined mathematical model of risk of progression that can stratify risk for patients having the same glucose measurement. The model may include NMR derived measurements of GlycA and a plurality of selected lipoprotein components of at least one biosample of the subject. | 12-12-2013 |
20130332083 | Gene Marker Sets And Methods For Classification Of Cancer Patients - The present invention relates to gene marker sets for use in classification of cancer patients on the basis of expression of multiple biological markers. The gene marker sets allow identification of the tissue of origin of a metastatic tumor, provide prognostic data on breast cancer recurrence, prognostic data on colon cancer recurrence in cancer patients, or prognosis of increased risk of death of lung cancer patients. The invention also provides methods of use of the gene marker sets for classification. The invention is particularly suited to the generation of microarrays and other high-throughput platforms for diagnostic and prognostic purposes. | 12-12-2013 |
20130332084 | DNA AND/OR RNA DETERMINATION FROM UV-VIS SPECTROPHOTOMETER DATA - A method for analyzing UV-VIS spectrophotometer data of a sample comprising at DNA and/or RNA is described. The method comprises receiving UV-VIS spectrophotometer data, fitting the UV-VIS spectrometer data taking into account at least one spectrum representative for a base pair being any of more of adenine-thymine (AT) or guanine-cytosine (GC) or adenine-uracil, and deriving from the fitting a quantification of an amount of DNA and/or RNA. | 12-12-2013 |
20130338928 | METHODS AND SYSTEMS FOR HIGH RESOLUTION MELT ANALYSIS OF A NUCLEIC ACID SEQUENCE - Described herein are methods and systems for analyzing and visualizing HRM data from a double-stranded nucleic acid. The HRM data is generally characterized by a plurality of data points each including a signal value associated with the concentration of a double-stranded nucleic acid in a sample and a temperature value associated with a the temperature of the sample. Embodiments of the invention analyze the HRM curves from samples using the first negative derivative of the HRM curve or a virtual standard. The first negative derivative plot method may be used to identify the melting temperature of a homogenous double-stranded nucleic acid in a sample, as well as the presence and melting temperature of heterogeneous double-stranded nucleic acids in the sample. Data points associated with the melting temperature are plotted on a scatter plot for analysis. The virtual standard allows for visualization of HRM data across data sets. | 12-19-2013 |
20130338929 | COMPUTERIZED METHOD AND SYSTEM FOR INFERRING GENETIC FINDINGS FOR A PATIENT - A method and system in a computing environment for inferring genetic findings for a patient is provided. The method includes receiving a request for genetic findings for a person from another application or a user. The method further includes inquiring as to whether the person has the genetic findings. If not, the method automatically provides inferred genetic findings for the person. The inferred genetic findings are calculated using genetic findings for family members of the patient, linkage analysis, haplotype analysis, semantic test results for the person and/or population genetics information. | 12-19-2013 |
20130338930 | DETERMINATION OF A MAGNETIC RESONANCE IMAGING PULSE SEQUENCE PROTOCOL CLASSIFICATION - A medical imaging device ( | 12-19-2013 |
20130338931 | Method for Ascertaining the Fertilizer Requirement, in Particular the Nitrogen Fertilizer Requirement, and Apparatus for Carrying Out the Method - A method and a device for discharging fertilizer for agricultural cultivated plants are disclosed. According to the invention, the required quantity of fertilizer is determined depending on the current nutrient uptake (nutrient status), optimum nutrient uptake (nutrient requirement) by the fertilizing deadline, and optimum nutrient uptake (nutrient requirement by the next fertilizing deadline, wherein other influencing factors are taken into consideration via a correction factor DIMA. | 12-19-2013 |
20130345986 | EXACT HAPLOTYPE RECONSTRICTION OF F2 POPULATIONS - Various embodiments reconstruct haplotypes from genotype data. In one embodiment, a set of progeny genotype data comprising n progenies encoded with m genetic markers is accessed. A first set of parent haplotypes associated with a first parent of the n progenies and a second set of parent haplotypes associated with a second parent of the n progenies are identified based on at least the set of progeny genotype data. A total minimum number of observable crossovers in the n progenies is determined. An agglomerate data structure comprising a collection of sets of haplotype sequences characterizing the n progenies is constructed based on the set of progeny genotype data and the first and second sets of parent haplotypes. Each set of haplotype sequences includes a number of crossovers equal to the total minimum number of observable crossovers in the n progenies. | 12-26-2013 |
20130345987 | EXACT HAPLOTYPE RECONSTRICTION OF F2 POPULATIONS - A system for reconstructing haplotypes from genotype data includes a memory, a processor, and a reconstruction module. The reconstruction module is configured to access a set of progeny genotype data including n progenies encoded with m genetic markers. A first set of parent haplotypes associated with a first parent of the n progenies and a second set of parent haplotypes associated with a second parent of the n progenies are identified based on at least the set of progeny genotype data. An agglomerate data structure including a collection of sets of haplotype sequences characterizing the n progenies is constructed based on the set of progeny genotype data and the first and second sets of parent haplotypes. Each set of haplotype sequences includes a number of crossovers equal to a total minimum number of observable crossovers in the n progenies. | 12-26-2013 |
20130345988 | SUMMARIZING AN AGGREGATE CONTRIBUTION TO A CHARACTERISTIC FOR AN INDIVIDUAL - Summarizing an aggregate contribution to a phenotypic characteristic for an individual includes: receiving information pertaining to the phenotypic characteristic of an individual; identifying, using one or more computer processors, a set of one or more markers associated with the phenotypic characteristic; obtaining a set of one or more marker measurements of the individual that corresponds to the set of one or more markers; obtaining a set of one or more statistical factors that measure associations between the set of one or more markers and the phenotypic characteristic; determining an aggregate contribution to the phenotypic characteristic of the individual based at least in part on the retrieved set of one or more statistical factors; and outputting a display characteristic to be displayed that is associated with the aggregate contribution to the phenotypic characteristic for the individual. | 12-26-2013 |
20140005947 | HEALTH CARE SYSTEM AND METHOD USING STRESS INDEX ACQUIRED FROM HEART RATE VARIATION | 01-02-2014 |
20140005948 | METHOD AND APPARATUS FOR PERFORMING QUANTITATIVE ANALYSIS OF NUCLEIC ACID USING REAL-TIME PCR | 01-02-2014 |
20140005949 | SYSTEMS AND METHODS OF DISCRIMINATING CONTROL SOLUTION FROM A PHYSIOLOGICAL SAMPLE | 01-02-2014 |
20140005950 | DEVICE AND METHOD FOR DETECTING AN ACTUATION ACTION PERFORMABLE WITH A MEDICAL DEVICE | 01-02-2014 |
20140005951 | Blood Glucose Measuring Device with Reliable Transmission of Values to an External Device | 01-02-2014 |
20140012509 | METHODS AND SYSTEMS FOR SYNCHRONIZATION AND DISTRIBUTION OF MULTIPLE PHYSIOLOGICAL AND PERFORMANCE MEASURES - Methods and systems are disclosed including receiving, by circuitry of a computer, physiological data comprising physiological information gathered by a physiological sensor regarding a subject, the subject having physiological reactions to an event that is external to the subject, wherein at least one of the physiological data also comprises a first time at which the physiological data was recorded, wherein the first time is based on a global reference time frame; receiving non-physiological data comprising information regarding the external event, wherein at least one of the non-physiological data also comprises a second time at which the non-physiological data was recorded, wherein the second time is based on the global reference time frame; correlating the physiological data with the non-physiological data based on the first and second times; and generating physiological reaction data indicative of a physiological reaction of the subject to the external event. | 01-09-2014 |
20140012510 | SYSTEMS AND METHODS FOR LEVERAGING SMARTPHONE FEATURES IN CONTINUOUS GLUCOSE MONITORING - The present embodiments harness a wide variety of capabilities of modern smartphones, and combine these capabilities with information from a continuous glucose monitor to provide diabetics and related people with more information than the continuous glucose monitor can provide by itself. The increased information provides the diabetic with an increased likelihood of good diabetes management for better health. | 01-09-2014 |
20140012511 | SYSTEMS AND METHODS FOR LEVERAGING SMARTPHONE FEATURES IN CONTINUOUS GLUCOSE MONITORING - The present embodiments harness a wide variety of capabilities of modern smartphones, and combine these capabilities with information from a continuous glucose monitor to provide diabetics and related people with more information than the continuous glucose monitor can provide by itself. The increased information provides the diabetic with an increased likelihood of good diabetes management for better health. | 01-09-2014 |
20140012512 | Biometric Monitoring Device having a Body Weight Sensor, and Methods of Operating Same - A system comprising a biometric monitoring device including a housing including a platform to receive at least one foot of the user, a body weight sensor to generate body weight data, processing circuitry to calculate user weight data which corresponds to the user's weight, using the body weight data, and communication circuitry to: (a) receive user identification data which identifies the user or a portable activity monitoring device, and (b) transmit the user weight data to data storage associated with the user identification data. The system further includes the portable activity monitoring device including a housing having a physical size and shape that is adapted to couple to the user's body, a sensor to generate sensor data, and communication circuitry to receive physiologic data which is based on the user weight data, and processing circuitry to calculate activity data using the sensor data and physiologic data. | 01-09-2014 |
20140019059 | Mapping Cognitive to Functional Ability - Methods, systems, and apparatus, including medium-encoded computer program products, for mapping cognitive to functional ability include receiving data regarding assessments of a cognitive ability and assessments of a functional ability; processing the received data to generate a map of one or more cognitive processes underlying the cognitive ability to a continuous-valued measure of the functional ability; and storing the generated map on a computer-storage medium to be used by a computer device in continuous-valued assessments of the functional ability. | 01-16-2014 |
20140019060 | Assisted Dosing of Aquatic Environments For Maintaining Water Quality Therein, and Systems, Methods, Apparatuses, and Software Relating Thereto - Methods of assisting human users with dosing of aquatic environments, such as aquariums, pools, hot tubs, ponds, etc., that utilize automated monitoring systems that continually monitor various parameters of the water in the aquatic environments. When one or more measured water parameters of an aquatic environment are out of tolerance, a dosing calculator uses water-quality information from a monitoring system to generate dosing instructions for a human user that instruct the user how to dose the aquatic environment with one or more additives that will put the one or more parameters back into tolerance. In some embodiments, input from a user is used to switch the monitoring system to a dosing mode from a normal monitoring mode to track the progress of the dosing more closely than the normal monitoring mode would. | 01-16-2014 |
20140019061 | METHOD AND APPARATUS FOR ANALYZING GENE INFORMATION FOR TREATMENT SELECTION - A method and apparatus for analyzing information about a gene network in which genes included in a genome of an individual are classified into a plurality of subgroups based on functional correlations between the genes is acquired, and subgroups corresponding to an action of at least one drug to be used are visualized. | 01-16-2014 |
20140019062 | Nucleic Acid Information Processing Device and Processing Method Thereof - A nucleic acid information processing device includes a storage unit that stores first base sequence information including information on a plurality of base sequences, and second base sequence information including information on a plurality of base sequences; a threshold value receiving unit adapted to receive information that identifies a similarity threshold; a hybridization unit adapted to identify a degree of similarity and a starting position and a finishing position of a similar portion for one to one combinations with the base sequences included in the first base sequence information as a target, and the base sequences included in the second base sequence information as a probe; and a similar base sequence counting unit adapted to count for each probe a number of the targets for which the identified degree of similarity is greater than or equal to the similarity threshold, and storing the count in the storage unit. | 01-16-2014 |
20140019063 | SHOE SENSOR SYSTEM - A system includes a pressure sensor and circuitry to collect information from the pressure sensor and transmit the information to a server. The pressure sensor and circuitry are formed as an integrated node adapted to be placed to sense pressure in the foot of an animal. The server processes the information to one or more devices. | 01-16-2014 |
20140025305 | System and Method for Forest Management Using Stand Development Performance as Measured by Leaf Area Index - A system and method for identifying stands or portions thereof that are not growing as expected. In one embodiment, a computer system compares a measured leaf area index of a stand that is determined from remotely sensed data to an expected leaf area index. The computer system identifies stands or portions of stands where the measured leaf area index is greater than the expected leaf area index and/or stands or portions of stands where the measured leaf area index is less than the expected leaf area index. In one embodiment, the comparison is used to identify stands or portions thereof where silviculture treatments may be necessary. In another embodiment, measured vegetation index or leaf area index values are used to manage the growth of secondary crops in a stand. VI or leaf area index values are compared with expected values to determine if silviculture treatments should be applied. | 01-23-2014 |
20140025306 | VARIABLE INDICATION ESTIMATOR - A variable indication estimator which determines an output value representative of a set of input data. For example, the estimator can reduce input data to estimates of a desired signal, select a time, and determine an output value from the estimates and the time. In one embodiment, the time is selected using one or more adjustable signal confidence parameters determine where along the estimates the output value will be computed. By varying the parameters, the characteristics of the output value are variable. For example, when input signal confidence is low, the parameters are adjusted so that the output value is a smoothed representation of the input signal. When input signal confidence is high, the parameters are adjusted so that the output value has a faster and more accurate response to the input signal. | 01-23-2014 |
20140025307 | DETERMINING A PROBABILISTIC DIAGNOSIS OF CANCER BY ANALYSIS OF GENOMIC COPY NUMBER VARIATIONS - The present invention provides methods and compositions related to genomic profiling, and in particular, to assigning probabilistic measure of clinical outcome for a patient having a disease or a tumor using segmented genomic profiles such as those produced by representational oligonucleotide microarray analysis (ROMA). | 01-23-2014 |
20140025308 | ESTIMATION OF RECENT SHARED ANCESTRY - Methods and systems are described for the estimation of recent shared ancestry (ERSA) from the number and lengths of identical-by-descent (IBD) nucleotide segments derived from, e.g., high-density single-nucleotide polymorphism data or whole-genome sequence data. ERSA is accurate to within one degree of relationship for 97% of first- through fifth-degree relatives and 80% of sixth- and seventh-degree relatives. ERSA's statistical power approaches the maximum theoretical limit imposed by the fact that distant relatives frequently share no DNA through a common ancestor. ERSA greatly expands the range of relationships that can be estimated from genetic data. | 01-23-2014 |
20140025309 | CALIBRATION SYSTEM WITH HUMAN-LIKE RESPONSE ACTUATOR - Methods are provided for calibrating stimulus-response test systems which include a stimulus output device for delivering a stimulus to a subject, and a response input device for receiving a response from the subject, said response input device comprising a response actuator that is capable of responding in human-like fashion to the stimulus-response test using variable motion control signals comprising one or more time offsets and one or more activation values, said activation values comprising variable speeds and forces for the response motion. | 01-23-2014 |
20140025310 | METHOD FOR DETERMINING THE EFFICACY OF A COMBINATION THERAPY - The present invention concerns the determination of weighted phenotypic sensitivity score (wPSS) for a combination therapy as being the combination of information about the inherent anti-viral potency of each drug, as determined through statistical analysis of response to anti-retroviral therapy combination regimens, with resistance information on the individual patient's virus to each anti-retroviral drug as well as the use of this wPSS for predicting the efficacy of a patient's therapy or for evaluating or optimizing a therapy. | 01-23-2014 |
20140025311 | Physiological Signal Quality Classification for Ambulatory Monitoring - Physiological signal quality classification methods and systems designed to improve ambulatory monitoring. Physiological signals are classified as good, noisy or weak based on signal properties. Once classified, signals are processed differently depending on their classification in order to encourage reliance on reliable physiological data, discourage reliance on unreliable physiological data and induce action to improve signal quality. For example, for a good signal, physiological data may be extracted from the signal and displayed to a person being monitored. For a noisy signal, a noisy signal notification may be displayed to the person in lieu of extracted physiological data. For a weak signal, a weak signal notification may be displayed to the person in lieu of extracted physiological data. Moreover, a noisy or weak signal notification displayed to a person being monitored may be accompanied by a corrective action recommendation, such as “move to quieter environment” for a noisy signal or “check body placement of sensor” for a weak signal. | 01-23-2014 |
20140032120 | Managing Flow/Volume Loop Information - Embodiments of the present invention provide methods of extracting optimal information from a flow/volume loop concerning the patient's respiratory condition by examining the overall shape of the space under the flow/volume loop's expiration portion. In some embodiments, this is done with reference to the center of mass of that space. In some embodiments, this is done with reference to the area of that space. Some embodiments are significantly less affected by random/statistical variations and/or noise within the measurement system than existing methods. | 01-30-2014 |
20140032121 | INTAKE ANALYSIS SYSTEM AND METHOD - Disclosed are an intake analysis system and a method thereof comprising an intake sensing device and a cloud computing device. The intake sensing device may be installed in a container containing an ingesta, providing for analyzing a component of the ingesta to generate a detecting signal, and sensing a weight variation of the container having the ingesta therein to generate a weight sensing signal; the cloud computing device receives the detecting signal and weight sensing signal transmitted and calculates a calorie value and an intake value to generate substance ingested information, and compares the calorie value and the intake value. When the calorie value or intake value is greater than a predetermined value respectively, the cloud computing device generates a noticing signal, and transmits the substance ingested information and noticing signal to the intake sensing device, and the intake sensing device displays the substance ingested information and noticing information. | 01-30-2014 |
20140032122 | GENE-WIDE SIGNIFICANCE (GWIS) TEST: NOVEL GENE-BASED METHODS FOR THE IDENTIFICATION OF GENETIC ASSOCIATIONS HAVING MULTIPLE INDEPENDENT EFFECTS - A novel set of methods for gene-based tests of association are provided. By gathering multiple independent effects into a single test, GWiS has greater power than conventional tests to identify genes with multiple causal variants. GWiS also retains power for low-frequency minor alleles that are increasingly important for personal genetics, a feature not shared by other multi-SNP tests. The methods of the present invention can be combined with conventional computing platforms to provide a new analytical tool for analyzing genes which are linked to multiple traits. | 01-30-2014 |
20140032123 | SYSTEM FOR MAKING AVAILABLE INDIVIDUAL OR POOLED, ALSO ANONYMOUS PATIENT DATA ON THE BASIS OF MOLECULAR GENOME, TRANSCRIPTOME, PROTEOME, EPIGENOME, OR METABOLOME DATA - The invention relates to a system for automatically, rapidly, and dynamically funding biological cells for transplantion, treatment, or research purposes between collection centers or banks (storage places) and hospitals, transplant centers, or research facilities, monitoring and assisting with processes from the transmission of requests, the delivery of cell preparation suitable for allogeneic transplantation, and the use of the found preparations to the monitoring of the result in the patient, and making said data available for statistical and other purposes, wherein samples are taken before and after the transplantation to analyze genomes, proteomes, transcriptomes, epigenomes, and/or metbolomes. | 01-30-2014 |
20140032124 | APPARATUS AND METHOD FOR CLASSIFYING ORIENTATION OF A BODY OF A MAMMAL - Apparatus is disclosed for providing classification of body orientation of a mammal. The apparatus includes means ( | 01-30-2014 |
20140032125 | Environment and Method for Rapid Analysis of Genomic Sequence Data - In one aspect, the present disclosure describes a method that may include receiving an indication of selection of a first diagnostic algorithm of two or more of diagnostic algorithms for analyzing genetic sequence data, where the indication is associated with an identifier. The method may further include retrieving, from a storage medium, first genetic sequencing data associated with the identifier and analyzing, by one or more processors, the first genetic sequencing data using the first diagnostic algorithm to obtain at least one diagnostic result. | 01-30-2014 |
20140032126 | MULTI-STAGE, REGRESSION-BASED PCR ANALYSIS SYSTEM - Systems and methods are provided for analyzing data to determine properties of a PCR processor other process exhibiting amplification or growth. Data representing an amplification can be distinguished from data representing a jump or other error. A modified sigmoid function containing a drift term may be used in determining the properties. A multi-stage functional fit of the amplification data can provide increased accuracy and consistency of one or more of the properties. A baseline of the amplification data can be determined by analyzing an integrated area of a first derivative function of the data. A reference quantitation value can also be determined from locations of maxima of different derivative functions of the amplification data, e.g., a weighted average of the maxima locations for the second and third derivatives may be used. | 01-30-2014 |
20140039801 | QUANTISED BIOMETRIC METHOD, APPARATUS AND COMPUTER PROGRAMME - A quantised biometric method comprising the steps of: acquiring a value of a biometric measurement variable from a registrant to generate an acquired registrant variable; identifying a container from a preconfigured number of containers each of preconfigured, substantially non-overlapping, upper and lower boundary values, whose boundary values substantially embrace the value of the acquired registrant variable, to generate a registrant container; adapting the upper and lower boundary values of the registrant container so that the acquired registrant variable is centred therein; adapting the upper and lower boundary values of the remaining containers so that they remain substantially non-overlapping with each other and those of the registrant container, to generate a plurality of registrant imposter containers; storing the boundary values of the registrant container and the registrant imposter containers and an acquired identity of the registrant; acquiring a value of the biometric measurement variable from a user to generate an acquired user variable; acquiring from the user a claim to an identity to generate a claimed identity; retrieving the containers of the registrant with the claimed identity to generate the claimed registrant container and claimed registrant imposter containers; deciding that the user has passed the quantised biometric method in the event the boundary values of the claimed registrant container substantially embrace the acquired user variable. | 02-06-2014 |
20140039802 | RAPID METHOD OF PATTERN RECOGNITION, MACHINE LEARNING, AND AUTOMATED GENOTYPE CLASSIFICATION THROUGH CORRELATION ANALYSIS OF DYNAMIC SIGNALS - The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of determining whether a genotype is present in a biological sample. The present invention includes methods and systems for determining whether a genotype is present in a biological sample, through generating a dynamic profile an unknown genotype, correlating the dynamic profile to an average profile for a known genotype to generate a correlation value, and determining whether the correlation value falls within an acceptable threshold to determine if the unknown genotype is the known genotype. The present invention also relates to methods and systems for generating a training set to allow a machine to recognize a known genotype from within a class of known genotypes through generating dynamic profiles of a known genotype, averaging the dynamic profiles to generate an average profile for the genotype, and correlating the dynamic profiles of the genotype with an average profile for each known genotype in a class of genotypes to generate a correlation vector. The training set generated by these methods and systems may be used to assist in identification of unknown genotypes. | 02-06-2014 |
20140039803 | Method for Rapid Identification of Drug Targets and Drug Mechanisms of Action in Human Cells - A method of identification of drug targets and drug resistance mechanisms in human cells of a drug comprising the steps of: generating at least one drug-resistant sample and at least one drug-sensitive sample; analyzing substantial portions of the genome and/or transcriptome of the least one drug-resistant sample and drug-sensitive sample to obtain sequencing data; detecting substantially all alterations in the at least drug-resistant sample; deriving a resistance signature; and performing analysis of the drug resistance signature of at least one recurrently altered gene using bioinformatic tools and cellular biology methods to determine if alteration of the at least one gene of the drug resistance signature is sufficient to confer at least partial resistance to cells or tissues against the drug. | 02-06-2014 |
20140039804 | Methods, Systems and Devices for Activity Tracking Device Data Synchronization With Computing Devices - Methods, systems and devices are provided for capturing activity data associated with activity of a user via a device and transferring the data to a client device at a selected defined transfer rate, based on an update condition. The activity data is captured over time. The activity data is stored in storage of the device. The method sets a data transfer rate between the device and the computing device based upon the detected update condition. The update condition is used to select one of a first transfer rate for transferring activity data captured and stored over a period of time or a second transfer rate for transferring activity data that is displayable in substantial-real time on the computing device. The first transfer rate is set in response to scaling-up a connection interval and the second transfer rate is set in response to scaling-down the connection interval. | 02-06-2014 |
20140046600 | SIM CARD BASED MEDICAL TESTING AND DATA TRANSMISSION SYSTEM - The present invention is a system for measuring and transmitting measuring a characteristic of a physiological fluid and transmitting said characteristic to a receiver, having a card constructed and arranged to perform analysis of a physiological fluid and said card configured to convert said analysis to an electronic file; a transmission device constructed and arranged to receive said card and transmit said electronic data file; and a receiver configured to be operatively associated with said transmission device for receiving said data transmitted thereto, wherein said receiver prepares an output based on reception of said electronic data. | 02-13-2014 |
20140046601 | METHOD FOR CALIBRATION AND QA - The present invention relates to the field of radiation therapy. In particular, the invention concerns a method of calibrating a positioning system in a radiation therapy system comprising a radiation therapy unit having a fixed radiation focus point. The method comprises the steps of: —releasably attaching a calibration tool to the fixation arrangement; —performing an image scanning procedure with the imaging system; —determining a position of the calibration tool in a coordinate system related to the imaging system; and —calculating a position difference between the determined position of the calibration tool in the coordinate system related to the imaging system and a position of the calibration tool in the stereotactic fixation unit coordinate system, thereby determining a relationship between the coordinate system related to the imaging system and the position of the calibration tool in the stereotactic fixation unit coordinate system. | 02-13-2014 |
20140052380 | METHOD AND APPARATUS FOR ANALYZING PERSONALIZED MULTI-OMICS DATA - A method and apparatus for analyzing personalized multi-omics data are disclosed. The method includes acquiring a plurality of biological data groups from an individual's gene sample, estimating indices indicating a degree of genetic abnormalities for the biological data groups, and generating a combined index by merging the estimated indices. | 02-20-2014 |
20140052381 | Systems and Methods for Detecting Homopolymer Insertions/Deletions - Systems and method for determining variants can receive mapped reads and determine a distribution of matched-filter residuals distribution from a plurality of reads at a homopolymer region. The distribution of matched-filter residuals can be fit to uni-modal and bi-modal models. Based on the model that best fits the distribution of matched-filter residuals, the heterozygosity of the sample and the absence or presence of an insertion/deletion in the homopolymer can be determined. | 02-20-2014 |
20140052382 | Method of Analysing Reagent Beads - A method of analysing reagent beads retained in a sample well of a sample plate is disclosed comprising obtaining an image of a reagent bead, distributing intensity values of image pixels amongst a plurality of intensity bins and generating an histogram. A curve is fitted to the histogram and the curve is compared with an idealised profile of image pixels. A closeness of fit between the curve and the idealised profile is determined and then intensity values are discarded from one or more of the intensity bins. The remaining intensity values are redistributed and the process is repeated several times. A determination is then made as to which curve has the closest fit with the idealised profile. | 02-20-2014 |
20140058679 | Wake Status Detection for Suppression and Initiation of Notifications - Parameters of an electronic device may be evaluated in order to determine a probability of a particular wake status of a user of the device. The determined probabilities of a certain wake status based on the evaluated parameters may be combined to identify a combined wake status of the user. The identified wake status may be utilized to implement certain device functionality. The wake status can enable a user to suppress notifications during a particular wake status or to perform an action (such as generating a reminder) according to a particular wake status. | 02-27-2014 |
20140058680 | SYSTEM AND A METHOD FOR PHYSIOLOGICAL MONITORING - A personal health monitor, including: (a) a physiological data input device operative to gather physiological data; (b) a detachable module that is detachably connected to a multi-purpose personal data accessory, operative to transmit the physiological data to the multi-purpose personal data accessory; and (c) the multi-purpose personal data accessory, whereas the multi-purpose personal data accessory is adapted to execute health monitoring software such as to enable the multi-purpose personal data accessory to receive the physiological data, process the physiological data to provide processed physiological data and control a long range transmission of the processed physiological data to a remote entity. | 02-27-2014 |
20140058681 | METHODS FOR JOINT CALLING OF BIOLOGICAL SEQUENCES - Methods and systems for simultaneously evaluating biological sequences across multiple population members, and methods and systems for simultaneously calling normal and cancerous biological sequences from a mixed sample containing normal and cancerous material are disclosed. This may be achieved by evaluating the probability of one or more hypothesis being correct for a plurality of population members based on biological sequence information for the population. For related family members, Mendelian inheritance may be integrated into the method. For populations, information from members under evaluation may be used to refine priors to more accurately call population members. Copy number variation, de novo mutations, and phenotypic traits and their genetic explanations may also be accommodated in the methods. Specific systems for implementing the methods are also disclosed. | 02-27-2014 |
20140058682 | Nucleic Acid Information Processing Device and Processing Method Thereof - It is an object of the present invention to enable simple design and change of a probe set that can be easily reused corresponding to a DNA microarray. A nucleic acid information processing device comprises: a storage unit that stores information on a plurality of base sequences; a threshold value receiving unit adapted to receive information that identifies a similarity threshold; a cluster configuration unit adapted to configure clusters by classifying the plurality of base sequences based on the similarity threshold; and a representative base sequence setting unit adapted to set one of the base sequences included in the cluster as a representative base sequence. | 02-27-2014 |
20140058683 | METHODS FOR ASSESSING DRUG EFFICACY AND RESPONSE OF A PATIENT TO THERAPY - Methods of identifying, monitoring and matching patients with appropriate treatments using a systemic mediator-associated physiologic test profile are provided. The methods of the present invention increase the likelihood of demonstrating clinical efficacy in clinical trial datasets. | 02-27-2014 |
20140067274 | METHOD FOR PROCESSING PHYSIOLOGICAL SIGNAL - Disclosed herein is a method for processing a physiological signal to measure physiological characteristics of a living organism. The method includes: (a) dividing P | 03-06-2014 |
20140067275 | MULTIDIMENSIONAL CLUSTER ANALYSIS - Disclosed is a method of cluster analysis of a data set of multidimensional observations. The method comprises: determining a set of quasi-optimal binwidths for the data set; partitioning, for a current binwidth in the set of quasi-optimal binwidths, the data set into a plurality of bins of width equal to the current binwidth; determining the number of modes of the partitioned data set for the current binwidth; and repeating the partitioning and determining the number of modes for each binwidth in the set of quasi-optimal binwidths. The number of clusters in the data set is the largest determined number of modes over the set of quasi-optimal binwidths. | 03-06-2014 |
20140067276 | METHODS FOR DIAGNOSIS AND INTERVENTION OF HEPATIC DISORDERS - The present disclosure concerns methods of administering and detecting a distinguishable agent in a sample from and assessing the condition of an organ in a subject. In a particular embodiment, the present invention concerns methods of detecting and comparing the cholate shunt, in a subject, preferably in a subject with chronic hepatitis C. In certain embodiments, the methods may comprise obtaining a sample from a subject such as a blood or saliva sample after administering an oral and intravenous dose of a distinguishable agent such as cholate and analyzing the sample clearance of the distinguishable agent from the subject and comparing the clearance levels in order to assess hepatic health. In another embodiment, the methods may comprise analyzing a sample from a subject for the presence of a distinguishable agent such as cholate and applying information obtained from analyzing the presence of the distinguishable agent to determine a treatment for a medical condition of the subject. | 03-06-2014 |
20140067277 | SNP DETECTION BY MELT CURVE CLUSTERING - Systems, methods and apparatus for an automated analysis of a collection of melt curves is provided. The analysis can identify certain characteristics of double stranded nucleotide sequences (e.g. DNA or other nucleotide sequences) which were melted. For example, a variation (e.g. a mutation) in the sequences (also called amplicons) may be determined from the analysis. The amplicons may be amplified via any amplification mechanism, such as PCR or Ligase chain reaction (LCR). The automated analysis can include identifying a melt region, normalizing a melt curve, and clustering melt curves. | 03-06-2014 |
20140067278 | Portable Monitoring Devices and Methods of Operating Same - The present inventions, in one aspect, are directed to a portable activity monitoring device comprising a housing having a physical size and shape that is adapted to couple to the user's body, a plurality of sensors (for example, motion sensor and altitude sensor) disposed in the housing. The monitoring device may further include processing circuitry, disposed in the housing and electrically coupled to the plurality of sensor, to calculate the activity points corresponding to the physical activity of the user using the sensor data, wherein the activity points correlate to an amount and intensity of the physical activity of the user, and output the data which is representative of the activity points. The monitoring device may also include a display, coupled to the processing circuitry, may output the data which is representative of the activity points to the user. | 03-06-2014 |
20140067279 | SIGNAL AVERAGING | 03-06-2014 |
20140074407 | DEVICE AND METHOD FOR ESTIMATING ENERGY EXPENDITURE DURING EXERCISE - The present invention relates to a device and method for estimating energy expenditure during exercise. The device includes a module for estimating whether a person is exceeding their anaerobic threshold and, if they are exceeding their anaerobic threshold calculating the additional energy expenditure due to the anaerobic metabolism of ATP. The additional energy expenditure can then be added to an estimate of the energy expenditure due to aerobic metabolism and output to the user in order to provide an estimate of the energy expenditure occurring during anaerobic exercise. | 03-13-2014 |
20140074408 | IDENTIFYING BIOLOGICAL RESPONSE PATHWAYS - A method for operating a machine for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response, accessing a database containing information characterizing molecular interactions, determining pathways connecting the identified molecules participating in the response, and solving an optimization problem. The pathways comprise nodes, each representing a molecule, and edges, each connecting a pair of nodes and representing an interaction between a respective pair of molecules represented by the pair of nodes. The nodes includes a subset that represent molecules identified as participating in the cellular response. Solving an optimization problem comprises determining a subset of the molecules and interactions having a minimum aggregate cost, associating each participating node with a penalty value, associating each edge with a cost value, forming an objective function based on the penalty and cost values, and identifying the sub-network of nodes and edges that minimizes the objective function. | 03-13-2014 |
20140081578 | Interactive Voluntary and Involuntary Caloric Intake Monitor - This invention is an interactive method and device for monitoring and measuring a person's food consumption and/or caloric intake which can function as part of an overall system for energy balance and weight management. This invention comprises collecting relatively less-intrusive data concerning a person's caloric intake, testing it for accuracy using the similarity and/or convergence of estimates, and collecting relatively more-intrusive data only if the criteria for similarity and/or convergence are not met. This invention yields a desired level of accuracy in caloric intake measurement with the least intrusion into the person's privacy and/or time. This invention provides the person with an incentive for accurate voluntary reporting of food consumption and engages them in managing their own energy balance and weight. | 03-20-2014 |
20140081579 | GREENHOUSE GAS GRID AND TRACKING SYSTEM - A method and computer system for reporting on a target greenhouse gas within a geographical boundary of an offset project by compiling policy parameters for the target greenhouse gas and generating a science plan for monitoring the target greenhouse gas for the target geographical boundary of the offset project, based upon the compiled policy parameters. An allometric model for the target greenhouse gas within the geographical boundary of the offset project is generated based upon the science plan of the target greenhouse gas for the geographic boundary, and a report for the target greenhouse gas within the target geographical boundary of the offset project is generated based upon the allometric model. | 03-20-2014 |
20140088880 | Systems and Methods for Versioning Hosted Software - Systems and methods for performing a validated analysis can include access to first and second versions of an analysis engine. The first version of the analysis engine can be used to perform a previously validated analysis. After the second version is made available, the first version can be continued to be used while the second version undergoes validation. The user can initiate a migration from the first version to the second version when the validation is complete. Access to both versions can be maintained for a period of time to allow users to migrate on their own schedule, and a common login interface can direct the user to a default version or allow the user to select an alternate version. | 03-27-2014 |
20140088881 | Information Processing Method - Systems, apparatus and methods including a contact lens that facilitates collection and/or processing of information associated with sensed features are provided. In one aspect, a system can include a contact lens and an analysis component external to the contact lens. The contact lens can include: a substrate; and a circuit, disposed on or within the substrate. The circuit can include: a plurality of sensors configured to sense respective features associated with a wearer of the contact lens; and a communication component configured to communicate information indicative of sensed features. The analysis component can be configured to: receive the information indicative of the sensed features; and generate statistical information based, at least, on the information indicative of the sensed features. | 03-27-2014 |
20140088882 | EVALUATING GENETIC DISORDERS - The present invention relates to genetic analysis and evaluation utilizing copy-number variants or polymorphisms. The methods utilize array comparative genomic hybridization and PCR assays to identify the significance of copy number variations in a subject or subject group. | 03-27-2014 |
20140088883 | Method and System for Knowledge Pattern Search and Analysis for Selecting Microorganisms Based on Desired Metabolic Property or Biological Behavior - Methods and systems for knowledge pattern search and analysis for selecting microorganisms based on desired metabolic properties or biological behaviors are disclosed in various embodiments of the invention. In one embodiment of the invention, a computer-implemented method for selecting a purpose-specific microorganism first compiles microorganisms' profiles by linking each microorganism's methanogenic, hydrogenic, electrogenic, another metabolic property, and/or another biological behavior to genetic and chemical fingerprints of metabolic and energy-generating biological pathways. Then, based on the compiled profiles of the microorganisms, the computer-implemented method groups the microorganisms into pathway characteristics using machine-learning and pattern recognition performed on a computer system, and subsequently generates a prediction called “discovered characteristics” for a desired metabolic property or a desired biological behavior of at least one microorganism. Furthermore, a profile match score may be calculated to indicate usefulness of one or more microorganisms for renewable energy generation from biological waste materials or wastewater. | 03-27-2014 |
20140095080 | UNIVERSAL METHOD TO DETERMINE REAL-TIME PCR CYCLE THRESHOLD VALUES - A single technique for determining Ct is provided that can be used for standard sigmoidal growth curves and for problematic growth curves, such as parabolic curves. The Ct value can be determined as the intersection of a line tangent to the growth curve at the maximum of the second derivative with a baseline of the growth curve. Such a Ct value is usable for sigmoidal curves and parabolic curves, and can provide linear calibration curves to achieve accuracy in determining initial concentrations of a sample. | 04-03-2014 |
20140095081 | Methods of Analyte Monitoring, and Devices and Systems Related Thereto - Methods, devices, and systems are provided that determine analyte trends according to different methods depending on whether a change-resistant state is active or not active. The method used when the change-resistant state is activated provides for different requirements for a resulting analyte trend to transition between states (e.g., level to non-level). Furthermore, in some aspects, methods, devices, and systems of selecting or modifying a response rate of an analyte monitoring device for an individual user are provided. User instructions for selecting or modifying a response rate of the device or system is received externally via a user interface or communication channel. The response rate of the analyte monitoring device or system is then selected or modified to the first response rate, and the device or system operated with the first response rate. | 04-03-2014 |
20140100787 | Assay Analysis, Tracking and Reporting System (AATR) - The Assay Analysis, Tracking and Reporting (AATR) is a software system to acquire and analyse Enzyme-Linked ImmunoSorbant Assays (ELISA) assays for the purspose of Antibody Screening, Detection, Concentration, Tracking, Dose Respone, Adsorption Analysis and Reporting using second/third/fourth degree polynomial, 4 and 5 Parameter Logistics best curve fitting regression analysis. AATR provides mechanism and capabilities to acquire data directly from Microplate Reader devices including batch mode and allows for import/export of ELISA data and sample ids for the tray. The regression analysis uses positive controls and negative controls and multiple standards data points. An average is calcuated for the duplicate samples. The software automatcialy color codes the wells and sample ids in the plate for the outliers data. Additional color coding and marker are used to designate the wells/samples above and below the highest and lowest thresold. AATR allows exporting of graphs, data points and reports in various formats. | 04-10-2014 |
20140100788 | METHOD OF MONITORING DIVING AND A SYSTEM FOR MONITORING OR PLANNING A DIVE - The invention concerns a method, device and computer program product for monitoring or planning a dive of a diver. The method includes providing data on the composition of gases breathed by the diver during the dive, providing data on the depth or ambient pressure of the diver, and using a model to provide a safe ascent profile for the diver based on the data on the composition of gases and on the depth or ambient pressure. According to the invention, the method further comprising detecting, based on the data on the composition of gases, a gas composition change which may lead to a deep tissue isobaric counter diffusion situation, and the model comprising means for immediately temporally retarding the ascent profile if such gas composition change is detected. The invention can be used to mitigate the harmful effects of dangerous breathing gas changes during diving. | 04-10-2014 |
20140100789 | NUCLEIC READS ALIGNING DEVICE AND ALIGNING METHOD THEREOF - Provided is a nucleic reads aligning method. More particularly, the present invention relates to a nucleic reads aligning method using a many-core process. A nucleic reads aligning device aligning a set of nucleic reads of a sequence to be analyzed with a reference sequence according to the present invention includes a main memory storing the reference sequence and the set of nucleic reads, a main processor splitting the reference sequence to produce first and second reference sequence fragments, and a many-core module aligning the set of nucleic reads with each of the first and second reference sequence fragments in parallel. The nucleic reads aligning device and method according to the present invention split a reference sequence and quickly align nucleic reads in a many-core environment. | 04-10-2014 |
20140100790 | INFORMATION PROCESSING SYSTEM USING NUCLEOTIDE SEQUENCE-RELATED INFORMATION - A system for processing information for providing semantic information and/or information associated with the semantic information useful for each individual organism through effective utilization of differences in nucleotide sequence-related information among individual organisms is constructed. The method for processing information on a nucleotide sequence comprises: (a) receiving request information for an object and/or service; (b) obtaining positional information in accordance with the request information from a memory having positional information representing a position in a nucleotide sequence memorized therein; and (c) obtaining nucleotide sequence-related information corresponding to the positional information obtained in (b) above, and obtaining semantic information implied by the nucleotide sequence-related information and/or information associated with the semantic information. | 04-10-2014 |
20140100791 | PATIENT-BASED RESULTS DISPLAY - A medical testing machine provides improved recall and display of the outcomes of tests performed by the machine. Test outcomes and other information are stored in mass storage directly accessible by the medical testing machine. In one aspect, outcomes of tests relating to a particular patient may be recalled. The system may be especially useful for tests that may be performed multiple times for a particular patient over a period of time, for example testing for HbAlc hemoglobin levels in diabetes patients. According to another aspect, the medical testing machine may store an accession number for each test outcome, and may enable a user to display as a group test outcomes having the same accession number. The system may store further information and associate it with particular test outcomes, for example calibration information. The system may also store a set of rules under which each test instance was run. | 04-10-2014 |
20140107931 | Method and apparatus for approximating effects of transcranial magnetic stimulation to a brain - The present invention relates generally to a method and apparatus for determining one or more cumulative effects of an application of transcranial magnetic stimulation to the brain of a subject, as well as a method and apparatus of representing same. According to an aspect of certain embodiments of the invention there is provided a method for determining one or more cumulative effects of an application of transcranial stimulation to one or more locations in a brain of a subject comprising the steps of applying multiple transcranial magnetic stimulation pulses to the brain, determining a dose of each of said stimulation pulses, measuring a physical response of the user and determining or approximating an accumulation of said response of said brain for each of said one or more locations in the brain of said subject. | 04-17-2014 |
20140107932 | PLATFORM FOR PROVIDING WELLNESS ASSESSMENTS AND RECOMMENDATIONS USING SENSOR DATA - Techniques associated with a platform for providing wellness assessments and recommendations using sensor data are described, including collecting local sensor data using a wearable device having a communication facility configured to connect to a network, accessing environmental data from third party databases, generating a wellness assessment using a rules based engine configured to process the local sensor data, the environmental data and historical user data, and generating a wellness recommendation using the wellness assessment. | 04-17-2014 |
20140107933 | GENE EXPRESSION BARCODE FOR NORMAL AND DISEASED TISSUE CLASSIFICATION - A computer-based method of creating a gene expression barcode includes the steps of determining an intensity of expression for each gene in a set of genes in a plurality of samples for at least one type; selecting genes in the set of genes that have at least two expression modes, based on the intensity; and creating a gene expression reference barcode, wherein each barcode bar corresponds to a selected gene and wherein the bar value is coded according to whether an intensity value for a selected gene is below or above a threshold value. | 04-17-2014 |
20140107934 | SYSTEMS AND METHODS FOR DETERMINING THE PROBABILITY OF A PREGNANCY AT A SELECTED POINT IN TIME - The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome. | 04-17-2014 |
20140107935 | METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW - Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. | 04-17-2014 |
20140107936 | CROSS-MODAL APPLICATION OF COMBINATION SIGNATURES INDICATIVE OF A PHENOTYPE - The present invention relates to a method of adapting a composite signature of a phenotype. The method comprises the steps of providing for a composite signature of a phenotype with at least two different data types, which were respectively generated by two different modalities of measuring a specimen. Due to an adaption of one part of the signature of the phenotype the resulting adapted phenotype signature can be used as an input for a signature evaluation tool that was derived from data measured by a third modality of measurement. | 04-17-2014 |
20140114579 | HLA TYPING USING SELECTIVE AMPLIFICATION AND SEQUENCING - Presented herein are methods and compositions for determining haplotypes in a sample. The methods are useful for obtaining sequence information regarding, for example, HLA type and haplotype. Also presented herein are methods of determining haplotypes in a sample based on a plurality sequence reads. | 04-24-2014 |
20140114580 | COMPUTERIZED METHOD AND DEVICE FOR ANALYZING PHYSIOLOGICAL SIGNAL - A computerized method and device for analyzing a physiological signal are provided. The computerized method for analyzing the physiological signal includes the following steps. A pulse waveform is measured by a measuring unit, wherein the pulse waveform represents a blood volume of a blood vessel over time. A plurality of rising segments of the plus waveform is analyzed by a processing unit. The maximum change rate point at each rising segment is analyzed by the processing unit. A pulse interval time sequence is obtained according to the maximum change rate points. | 04-24-2014 |
20140114581 | USING GAME THEORY IN IDENTIFYING COMPOUNDS THAT BIND TO TARGETS - A method performed by one or more processing devices includes retrieving information indicative of compounds and mutations of a target; generating one or more predictions of binding affinities of the compounds to the mutations; generating a simulation for introducing at least one of the compounds in response to at least one of the mutations; identifying, based on an application of a game theory algorithm to the simulation and to the one or more predictions, an equilibrium of the simulation; and identifying, from the equilibrium, a subset of the compounds with an increased binding affinity to the mutations relative to other binding affinities of other of the compounds. | 04-24-2014 |
20140114582 | SYSTEM AND METHOD FOR GENOTYPING USING INFORMED ERROR PROFILES - A system and method for genotyping tandem repeats in sequencing data. The invention uses Bayesian model selection guided by an empirically-derived error model that incorporates properties of sequence reads and reference sequences to which they map. | 04-24-2014 |
20140114583 | PREDICTING NEONATAL HYPERBILIRUBINEMIA - A multi-variable statistical predictive leading-indicator approach is employed for identifying newborns at risk of clinically significant hyperbilirubinemia and for determining to administer interventions to at-risk newborns. In embodiments, a multi-variable logistic regression statistical model capable of calculating a probability of clinically significant hyperbilirubinemia is generated. Using an input data set for a newborn and the multi-variable logistic regression statistical model, a probability of clinically significant hyperbilirubinemia is determined for the newborn and presented to a clinician. | 04-24-2014 |
20140121982 | METHOD AND APPARATUS FOR DETERMINING BIOMETRICS UTILIZING 3-DIMENSIONAL SENSOR DATA - An approach is provided for processing various sensor data and determining various characteristics associated with a user. A data collection module may process and/or facilitate a processing of sensor data for determining one or more distance measurements between at least one body part of a user and a device. The data collection module may determine one or more biometrical characteristics associated with the user based, at least in part, on the one or more distance measurements. | 05-01-2014 |
20140121983 | SYSTEM AND METHOD FOR ALIGNING GENOME SEQUENCE - There is Provided a method and system for aligning a genome sequence. The system for aligning a genome sequence includes a fragment sequence producing unit producing a plurality of fragment sequences from a read sequence, a filtering unit forming a set of candidate fragment sequences only including those of the plurality of the produced fragment sequences matching a target sequence, a fragment sequence elongating unit calculating the number of mapping positions of each of the candidate fragment sequences to the target sequence, selecting a fragment sequence in which the calculated number of mapping positions is higher than a predetermined value and elongating the selected fragment sequence until the number of mapping positions to the target sequence approaches the predetermined value or less, a mapping length calculating unit dividing the target sequence into a plurality of sections and calculating a total mapping length of the candidate fragment sequences by sections, and an aligning unit selecting a section in which the calculated total mapping length is a reference value or more and performing global alignment of the read sequence with respect to the selected section. | 05-01-2014 |
20140121984 | MOLECULAR FINGERPRINTING TO IDENTIFY INBREEDING AND OUTBREEDING DEPRESSIONS - Systems and methods for molecular fingerprinting to identify Inbreeding and Outbreeding Depression Factors (IODFs) in an animal are described. In one aspect, the systems and methods receive inputs such as information pertaining to a set of loci, allele quantity and size, genotype, and/or so on. The systems and methods calculate, based on at least a subset of inputs and a set of microsatellite markers, an IODF. The systems and methods evaluate the calculated IODF to determine if the animal is a suitable/good candidate for a breeding program. | 05-01-2014 |
20140121985 | CLASSIFICATION OF NUCLEOTIDE SEQUENCES BY LATENT SEMANTIC ANALYSIS - DNA sequences are analyzed using latent semantic analysis. A set of nucleotide sequences is received in which the set has a first number of sequences. A set of basis vectors is determined, in which the set has a second number of basis vectors, the second number being smaller than the first number. Each basis vector represents a specific combination of predetermined nucleotide segments. For each of the nucleotide sequences, an approximate representation of the nucleotide sequence is determined based on a combination of the basis vectors. For each pair of nucleotide sequences, a distance between the pair of nucleotide sequences is determined according the distance between the approximate representation of the pair of nucleotide sequences. The set of nucleotide sequences are classified based on the distances between the pairs of nucleotide sequences. | 05-01-2014 |
20140121986 | SYSTEM AND METHOD FOR ALIGNING GENOME SEQUENCE - A system and a method for aligning a first and second genome sequences in a reference sequence includes a seed generation unit configured to generate one or more fragments from each of the first sequence and the second sequence and constitute a first seed group and a second seed group from the one or more fragments, a mapping value calculation unit configured to divide the reference sequence into a plurality of sections, and calculate a first mapping value of seeds included in the first seed group and a second mapping value of seeds included in the second seed group for each section, and an alignment unit configured to select a first section in which both the first and second mapping values are greater than or equal to a reference value and search for mapping positions of the first sequence and the second sequence in the first section. | 05-01-2014 |
20140121987 | SYSTEM AND METHOD FOR ALIGNING GENOME SEQUENCE CONSIDERING ENTIRE READ - A system and a method for aligning a genome sequence considering an entire read are provided. The system for aligning a genome sequence includes a fragment sequence production unit configured to produce one or more fragment sequences from an entire section of a read sequence, and an alignment unit configured to perform global alignment on the read sequence using the produced fragment sequences. | 05-01-2014 |
20140121988 | SYSTEM AND METHOD FOR ALIGNING GENOME SEQUENCE CONSIDERING REPEATS - A system and a method for aligning a genome sequence considering repeats are provided. The system for aligning a genome sequence includes a fragment sequence production unit configured to produce a plurality of fragment sequences from a read, a fragment sequence length adjustment unit configured to select the fragment sequences whose mapping repeat numbers in a target sequence exceed a predetermined reference value from the plurality of produced fragment sequences and adjust lengths of the selected fragment sequences until the mapping repeat numbers of the selected fragment sequences reach a value equal to or less than the reference value, and an alignment unit configured to perform global alignment using the fragment sequences having the adjusted lengths. | 05-01-2014 |
20140121989 | SYSTEMS AND METHODS FOR PROCESSING ANALYTE SENSOR DATA - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for processing sensor data, including calculating a rate of change of sensor data and/or determining an acceptability of sensor or reference data. | 05-01-2014 |
20140129151 | SYSTEMS AND METHODS FOR MANAGING GLYCEMIC VARIABILITY - Methods and apparatus, including computer program products, are provided for processing analyte data. In some example implementations, a method may include generating glucose sensor data indicative of a host's glucose concentration using a glucose sensor; calculating a glycemic variability index (GVI) value based on the glucose sensor data; and providing output to a user responsive to the calculated glycemic variability index value. The GVI may be a ratio of a length of a line representative of the sensor data and an ideal length of the line. Related systems, methods, and articles of manufacture are also disclosed. | 05-08-2014 |
20140129152 | Methods, Systems and Devices Comprising Support Vector Machine for Regulatory Sequence Features - The present invention comprises methods and systems for identifying enhancer sequences in DNA, for example, in mammalian genomes. The enhancer sequences are identified using a trained support vector machine (SVM) as disclosed herein. | 05-08-2014 |
20140136118 | METHODS FOR EVALUATING CANINE PHYSICAL ACTIVITY - The invention provides methods and devices for evaluating and tracking canine physical activity by determining for a canine (1) the duration of an activity or exercise; the speed of the activity or exercise based on the type of activity or exercise pace, e.g., walking, trotting, cantering, or running; a breed category factor to accommodate speed differences in distance travelled because of differences in body size and stride length; and an age factor and (2) calculating physical activity points (PAP) for the canine using an equation designed to accept input for the variables in (1) and use those variables to calculate PAP. The results from the equation are used to evaluate the physical activity of the canine and, based upon the evaluation, alter, if required, the canine's physical activity in a way that benefits the canine, particularly the canine's health. | 05-15-2014 |
20140136119 | RATING A PHYSICAL CAPABILITY BY MOTION ANALYSIS - Motion Analysis is used to classify or rate human capability in a physical domain via a minimized movement and data collection protocol optionally producing a discreet, overall figure of merit of the selected physical capability. The minimal protocol can be determined by data mining or other analysis of a more extensive movement and data collection. Protocols can be relevant in medical, sports and occupational applications. Kinematic, kinetic, body type, Electromyography (EMG), Ground Reactive Force (GRF), demographic, and psychological data can be encompassed. Resulting protocols can be capable of transforming raw data representing specific human motions into an objective rating of a skill or capability related to those motions. | 05-15-2014 |
20140142861 | Biomarkers For Predicting Progressive Joint Damage - A method scores a sample, by receiving a first dataset associated with a first sample obtained from a first subject, wherein said first dataset comprises quantitative data for at least two markers selected from the group consisting of: CCL22; CHI3L1; COMP; CRP; CSF1; CXCL10; EGF; ICAM1; ICAM3; ICTP; IL1B; IL2RA; IL6; IL6R; IL8; LEP; MMP1; MMP3; PYD; RETN; SAA1; THBD; TIMP1; TNFRSF11B; TNFRSF1A; TNFSF11; VCAM1; and VEGFA; and determining a first SDI score from said first dataset using an interpretation function, wherein the first SDI score provides a quantitative measure of the rate of change in joint structural damage in said first subject. | 05-22-2014 |
20140142862 | BEHAVIOR ESTIMATION APPARATUS, THRESHOLD CALCULATION APPARATUS, BEHAVIOR ESTIMATION METHOD AND NON-TRANSITORY COMPUTER READABLE MEDIUM THEREOF - According to one embodiment, a behavior estimation apparatus includes a storage unit, a first calculation unit, a second calculation unit, and an estimation unit. The storage unit stores first data collecting power values consumed by a consumer in a period. The first calculation unit calculates second data representing a frequency of each power value by using the first data. The second calculation unit calculates a first threshold to divide a first power value from a second power value which is larger than and next to the first power value, among power values corresponding to maximal values of frequencies included in the second data. The estimation unit obtains a power value consumed by the consumer in an estimating period, and estimates the consumer's behavior status in the estimating period by using the power value and the first threshold. | 05-22-2014 |
20140142863 | Methods And Systems For Orthopedic And Bone Disease Treatment - Methods and systems for orthopedic treatment and bone disease treatment are disclosed. An example method can comprise creating a level set function, receiving bone marrow biopsy data, determining a plurality of parameters of the level set function based on the bone marrow biopsy data, determining a bone marrow interface, and predicting bone mass, bone volume, cell counts and spatial distributions for one or more of, osteoclasts, osteoblasts, pre-osteoblasts, osteocytes, plasma cells, stromal cells, and tumor cells. The disclosed methods and systems can predict treatment outcome of a bone disease for a specific patient. In an aspect, the disclosed methods and systems can incorporate cellular interactions implicitly and therefore do not need to refer explicitly to any of the biochemistry in the system. | 05-22-2014 |
20140142864 | METHOD AND APPARATUS FOR MEASURING EXPENDED ENERGY - A method of measuring expended energy of a moving body, comprising the steps: i) providing at least one first sensor for measuring position data and/or orientation data and/or dynamic data of a first part of the moving body; ii) providing at least one second sensor for measuring relative position data and/or orientation data and/or dynamic data of a second part of the moving body, wherein the second part is moveable relative to the first part and connected to the first part by a first resistive deformable element; iii) using the at least one first sensor to make a first measurement of the position and/or orientation and/or dynamics of the first part over a period of time and subsequently calculating a global expended energy of the first part relative to a reference frame from the first measurement; iv) using the at least one second sensor to make a second measurement of the position and/or orientation and/or dynamics of the second part over said period of time and subsequently calculating a relative expended energy of the second part relative to the first part from the first and second measurements, wherein the calculation includes the energy required to deform the first resistive deformable element when moving the second part relative to the first part; and v) calculating the total expended energy of the moving body by summing the global expended energy with the relative expended energy; wherein the at least one first sensor comprises a global positioning system (GPS) sensor and/or an inertial measurement unit and/or a first plurality of reference indicia measurable by an image capture device; and the at least one second sensor comprises an inertial measurement unit and/or a second plurality of reference indicia measurable by an image capture device. | 05-22-2014 |
20140149047 | Dynamic and Differential Analysis - The present invention provides methods to improve upon prostate cancer screening, thereby saving lives and reducing morbidities of unwarranted biopsies and over-treatment. The methods use a systematic analysis of the growth rate of PSA from cancer and PSA variation and the way in which they might be used to distinguish high-risk cancers from no cancer. Approaches include Dynamic-Differential Strategy, Dynamic-Differential Analysis, and Dynamic Analysis. | 05-29-2014 |
20140156196 | MOLDED WRISTBAND CASE - A biometric monitoring device and multiple carrying cases for same are provided. In some implementations, the case may be made from a flexible viscoelastic material and the biometric monitoring device may be slipped into a receptacle in the case through an opening in the case; the opening may become distended during the insertion of the biometric monitoring device. In some implementations, the case may feature a display window that, in combination with materials of the biometric monitoring device, may mask a display of the biometric monitoring device from view when the display is off and may allow the display to be seen when the display is displaying content. | 06-05-2014 |
20140156197 | METHOD AND APPARATUS FOR PROCESSING SIGNAL - A method of processing a signal may include receiving an input signal including a motion artifact, determining a filter parameter based on a frequency component of a motion-based signal analogous to the motion artifact, and filtering the input signal using a filter having the determined filter parameter. | 06-05-2014 |
20140156198 | Determining Coronary Artery Disease Risk - Markers and methods useful for assessing coronary artery disease in a subject are provided, along with kits for measuring their expression. Also provided are predictive models, based on the markers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. | 06-05-2014 |
20140156199 | MOLECULAR PROFILING OF TUMORS - Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | 06-05-2014 |
20140156200 | ASSESSMENT OF CELLULAR SIGNALING PATHWAY ACTIVITY USING PROBABILISTIC MODELING OF TARGET GENE EXPRESSION - The present application mainly relates to specific methods for inferring activity of one or more cellular signaling pathway(s) in tissue of a medical subject based at least on the expression level(s) of one or more target gene(s) of the cellular signaling pathway(s) measured in an extracted sample of the tissue of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods. | 06-05-2014 |
20140163891 | APPARATUS AND METHOD FOR REAL-TIME EMOTION RECOGNITION USING HEART RATE VARIABILITY - An apparatus and method for recognizing an emotion by use of a heart rate data is provided. The apparatus includes an input signal generation unit configured to receive a plurality of heart rate data, and generate input signals each having a sequence, a signal classification unit configured to classify the input signals into groups, and an emotion recognition unit configured to search for a group, to which the input signal generated by the input signal generation unit belongs, among the groups classified by the signal classification unit, and recognize a user emotion corresponding to the found group. | 06-12-2014 |
20140163892 | METHOD FOR DETERMINING IF AN IMPLANTABLE MEDICAL DEVICE IS MAGNETIC RESONANCE CONDITIONAL - A method for determining if an implantable medical device (IMD) in a patient is magnetic resonance conditional. Embodiments include a Home Monitoring Service Center (HMSC) that indicates if the IMD is MR conditional and what those conditions are. The IMD includes memory with flags, enabling a physician to set a flag to “MR conditional” if the IMD is MR conditional, if there are no abandoned leads in the patient, and if there are no other hardware in the patient that are not MR conditionally approved. In embodiments, the flags indicate safe for 1.5 T, 3.0 T, 1.5 & 3.0 T, up to 2 W/Kg, up to 4 W/Kg, with/without exclusion zone, and date flags are set. During home monitoring, the HMSC reads out a status of the MR conditional flags and the date last confirmed. If the patient needs an MRI scan, physician queries HMSC to determine MR conditional status. | 06-12-2014 |
20140163893 | METHOD, APPARATUS AND COMPUTER PROGRAM FOR CALCULATING CURRENT DISTRIBUTION INSIDE BRAIN - Apparatus for calculating current distribution inside brain includes: initial grid setting unit configured to set grid points constituting grid with predetermined pitch; current calculating unit configured to calculate current value at each grid point based on the electromagnetic information, by solving forward problem to obtain lead field matrix and by solving inverse problem to obtain current source vector; sub-grid setting unit configured to set grid points constituting sub-grid with smaller pitch, only for subset of the previously set grid, based on the current value at each grid point calculated in the preceding current calculating step; and calculation executing unit configured to repeat setting the sub-grid and calculating the current source vector by the sub-grid setting unit and the current calculating unit one or more times, after calculation of current source vector corresponding to the initial grid is executed by the initial grid setting unit and the current calculating unit. | 06-12-2014 |
20140163894 | MOTIF FINDING PROGRAM, INFORMATION PROCESSOR AND MOTIF FINDING METHOD - A motif finding program is configured to enable an information processor to function as an extraction unit, an alignment unit, a calculation unit and a determination unit. The extraction unit extracts a plurality of sequence fragments as ortholog candidates upstream of the respective transcriptional start sites in DNA sequences of a species of interest and species for comparison. The alignment unit aligns the sequence fragments. The calculation unit calculates a first statistics based on a likelihood ratio of the likelihood that the sequence fragments are orthologous versus the likelihood that they are non-orthologous; and a second statistics representing a degree of conservation among the sequence fragments. The determination unit determines transcription factor binding site motif candidates in a sequence fragment of the species of interest, on the basis of the first statistics and the second statistics. | 06-12-2014 |
20140163895 | SYSTEM AND METHOD FOR ASSESSING HEALTH RISK FOR MIXED BREED ANIMALS - There is disclosed a computer-implemented method of assessing health risk for a mixed breed animal, the method including: providing disease data, the disease data including disease scores for a plurality of candidate diseases for each of a plurality of breeds; receiving biological data relating to the mixed breed animal, the biological data including identification of two or more parent breeds which are in the ancestry of the mixed breed animal; determining disease scores, from the disease data, for the two or more parent breeds; summa rising the disease scores across the two or more parent breeds to generate a combined health risk score for each of the candidate diseases; and generating, from the combined health risk scores, a ranked list of diseases. | 06-12-2014 |
20140163896 | HIV INCIDENCE ASSAYS WITH HIGH SENSITIVITY AND SPECIFICITY - The invention provides methods for manipulating the distribution of HIV gene sequences from a subject infected with HIV to classify whether the subject has been infected for more or less than a year. The Methods are useful, for example, in determining whether prophylactic interventions such as vaccines or drug candidates are slowing the rate of transmission in a population. | 06-12-2014 |
20140163897 | System and Method for Detecting a Baseline Gradient - The disclosed embodiments relate to a system and method for analyzing data. An exemplary method comprises the acts of receiving data corresponding to at least one time series, and computing a plurality of sequential instability index values of the data. An exemplary system comprises a source of data indicative of at least one time series of data, and a processor that is adapted to compute at least one of a plurality of sequential instability index values of the data. | 06-12-2014 |
20140163898 | Methods, Systems, and Products for Measuring Health - Methods, systems, and products measure health data related to a user. A time-stamped device identifier is received that uniquely identifies a communications device. A time-stamped sensor measurement is separately received. A difference in time between the time-stamped device identifier and the time-stamped sensor measurement is determined. When the difference in time is within a window of time, then the sensor measurement is associated with the device identifier. | 06-12-2014 |
20140163899 | System of Estimating the Cross-Sectional Area of a Molecule for Use in the Prediction of Ion Mobility - A method of estimating the cross-sectional area of a molecule for use in the prediction of ion mobility gives gas phase interaction radii determination and cross-sectional algorithm computation to provide separation and characterisation of structurally related isomers. More specifically, the invention provides a method of correlating the differences in the molecular structures with differences in anti-cancer activity of pre-determined anti-cancer drugs by utilizing a new algorithm for estimating the cross-sectional area of the molecules of such drugs. | 06-12-2014 |
20140172309 | CONTEXT AWARE BLOOD GLUCOSE MEASUREMENT SYSTEM - A blood glucose measurement system is configured to detect a wireless communication channel in proximity to the measurement system. An electronic data management unit of the measurement system automatically identifies a source of the detected wireless communication channel and uses the source information based on a stored rule set to automatically adjust at least one feature relating to the measurement system for use thereof. | 06-19-2014 |
20140172310 | SYSTEMS AND METHODS FOR CONTROLLING ACQUISITION OF SENSOR INFORMATION - Systems and methods are described for controlling acquisition of sensor information, including: one or more physiological sensors and a computing device including a processor programmed to query the physiological sensors to measure one or more physiological parameters of an individual in response to at least one flag indicating a need to measure the one or more physiological parameters; receive a set of sensor values from the physiological sensors; assign a quality value to the set of sensor values received from the physiological sensors; retain the set of sensor values if the assigned quality value of the set of sensor values meets or exceeds a minimum quality value threshold; and update the at least one flag if the assigned quality value of the set of sensor values meets or exceeds the minimum quality value threshold. | 06-19-2014 |
20140172311 | METHOD AND APPARATUS FOR CALIBRATION AND TESTING OF SCIENTIFIC MEASUREMENT EQUIPMENT - Discussed herein are methods and apparatuses to produce profiles for scientific measurement equipment and to use those profiles for various purposes in using, designing, calibrating and managing such equipment, such as to carry out critical laboratory testing. In this approach, either the analyzers' quality control data or serial patient data are numerically reduced to generate graphical precision profiles. Precision profiles for serial patient data show increased (im)precision vs time implying increased patient variation over increased time. Precision profiles for quality control data, according to one implementation, can demonstrate three different zones: 1) increased imprecision for quality control determinations that are close spaced (implies the discovery of an error condition and rapid reanalysis, 2) the usual imprecision and 3) a zone of increased imprecision which indicates either a need for a quality control analysis or re-calibration. | 06-19-2014 |
20140172312 | STABLE GENES IN COMPARATIVE TRANSCRIPTOMICS - Various embodiments perform stable gene analysis of transcriptome sequencing data. In one embodiment, a plurality of datasets each including transcriptome sequencing data are received by a processor. Each of the plurality of datasets includes a plurality of genes and a respective ranking value for each of the plurality of genes. A plurality of rank normalized input datasets is generated based on assigning, for each of the plurality of datasets, a rank to each of the plurality of genes. One or more longest increasing subsequence (LIS) of ranks are identified between each pair of the plurality of rank normalized input datasets. A set of stable genes from the plurality of genes is identified based on each of the one or more LIS of ranks across the plurality of rank normalized input datasets. | 06-19-2014 |
20140172313 | HEALTH, LIFESTYLE AND FITNESS MANAGEMENT SYSTEM - Devices, methods, and systems for modulating a user's personal health are presented. In one aspect, a device containing a sensor is configured for tracking, measuring, and modulating a characteristic is provided. In certain instances, the characteristic to be measured pertains to food consumption. A personal health modulating device for communicating health modulating data with a mobile computing device is presented. The mobile computing device includes at least one electronic data input for receiving electronic data, at least one wireless transceiver for communicating with a wireless network, and an interactive display. The personal health modulating device includes a wearable unit configured to be worn on a part of a user's body, the wearable unit having one or more sensors to sense an environment of the user, to gather data representing one or more attributes related to an activity of a user within the environment, the data being selected for processing according to one or more personal health modulating data processing routines, the wearable unit further having a transmitter to transmit the data to the at least one electronic data input of the mobile computing device. | 06-19-2014 |
20140172314 | SYSTEMS AND METHODS FOR DETERMINING CALORIC INTAKE USING A PERSONAL CORRELATION FACTOR - Systems and methods are provided for determining an individual's personal correlation factor and, using the personal correlation factor, determining the individual's caloric intake. A method for determining a personal correlation factor includes determining a body composition change over a calibration period, converting the body composition change to an equivalent energy value, and dividing the equivalent energy value by a net caloric value for the same calibration period, wherein the net caloric value includes a caloric expenditure less a caloric intake. A method for determining a subsequent caloric intake includes converting a body composition change to an equivalent energy value, dividing the equivalent energy value by the personal correlation value, and adding to this quotient the individual's caloric expenditure, wherein each step is performed using a processor. | 06-19-2014 |
20140172315 | Operation and Verification of A Portable Clinical Analysis System - The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof. | 06-19-2014 |
20140172316 | Portable Clinical Analysis System for Hematocrit Measurement - The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof. | 06-19-2014 |
20140172317 | METHOD AND APPARATUS FOR PERFORMING DRUG SCREENING - Provided are a method and apparatus for performing drug screening. The method includes: obtaining statistical data regarding prognostic indices that indicate a recurrence likelihood of a disease and expression levels of phenotype features from biological samples; obtaining drug data regarding expression levels of the determined phenotype features that are changed by administering different types of drugs to the biological samples; and screening efficacy of the administered drugs by using the obtained statistical data and the obtained drug data. | 06-19-2014 |
20140172318 | COST-OPTIMIZED DESIGN ANALYSIS FOR RAPID MICROBIAL PROTOTYPING - Computer-implemented methods for providing improvements in genome-scale metabolic models are described. The methods identify and optimize metabolic flux states that minimize the cost of enzyme production while maximizing a desired cellular phenotype. The computer-implemented methods may maximize cellular phenotypes such as growth (biomass) or production of a metabolite, such as a commercially valuable chemical compound, through the selection of metabolic pathways that maximize these phenotypes while minimizing metabolic costs associated with production of the proteomic constituents of individual metabolic pathways. The computer implemented methods may be useful for computationally designing microbial strains for the production of chemicals. | 06-19-2014 |
20140172319 | MOLECULAR PROFILING OF TUMORS - Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | 06-19-2014 |
20140180594 | METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS - Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations. | 06-26-2014 |
20140180595 | DEVICE STATE DEPENDENT USER INTERFACE MANAGEMENT - A biometric monitoring device with a display is provided. The display may, in response to receiving page advance requests from a user, advance through a plurality of different data display pages, at least some of which show aspects of biometric data recorded by the device. The biometric monitoring device may also, based on the biometric data, modify the sequential display order of the data display pages. In some implementations, a biometric monitoring device integrated into a wristband may be configured to turn a display of the biometric monitoring device on and display the time in response to biometric sensors of the biometric monitoring device detecting motion of the wearer's forearm consistent with moving the forearm into a watch-viewing position. | 06-26-2014 |
20140180596 | EFFECTIVE ROOT ZONE USE IN CROP MANAGEMENT - Embodiments of the present disclosure relate generally to nutrient monitoring in an agricultural field, and more specifically to systems, devices, and methods for tracking the fate and transport of nitrogen in agricultural environments and for determining an effective root zone of a crop. | 06-26-2014 |
20140180597 | EXTRACTING APERIODIC COMPONENTS FROM A TIME-SERIES WAVE DATA SET - A method is described for extracting aperiodic components from a time-series wave data set for diagnosis purposes. The method may include collecting time-series wave data within a controlled environment were a plurality of contrasting conditions can be used in collecting the time-series wave data set. Aperiodic components can be extracted from the time-series wave data set and the aperiodic components can then be fitted to the plurality of contrasting conditions of the controlled environment to product regressed aperiodic components from which diagnostic determination can be made. | 06-26-2014 |
20140180598 | SYSTEMS AND METHOD USING AN INDIVIDUALS PREDICTED TYPE TO DIAGNOSE A MEDICAL CONDITION - The methods and systems described herein may involve determining at least one lifeotype of at least one individual, analyzing the at least one lifeotype, and delivering content to at least one individual based on the analysis. The methods and systems described herein may involve providing a game, determining at least one lifeotype of at least one player of the game, analyzing the at least one lifeotype, and affecting the game play based on the analysis. The methods and systems described herein may involve providing an interactive space, determining at least one lifeotype of at least one individual in the space, analyzing the at least one lifeotype, and modifying at least one attribute of the space based on the analysis. | 06-26-2014 |
20140180599 | METHODS AND APPARATUS FOR ANALYZING GENETIC INFORMATION - Provided are a method and apparatus for analyzing genetic information to acquire expression data of a subject with respect to gene expression patterns of genes included in a gene network and determine a genetic abnormality of the gene network included in the expression data of the subject by using a representative expression pattern estimated from a group of normal people. | 06-26-2014 |
20140180600 | HIGH-RESOLUTION MELTING ANALYSIS - The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. In one aspect, methods and systems are disclosed for identifying a nucleic acid in a sample including an unknown nucleic acid and for detecting a single nucleotide polymorphism in a nucleic acid in a sample. In another aspect, methods and systems are disclosed for identification of a nucleic acid in a biological sample including at least one unknown nucleic acid by fitting denaturation data including measurements of a quantifiable physical change of the sample at a plurality of independent sample property points to a function to determine an intrinsic physical value and to obtain an estimated physical change function, and identifying the nucleic acid in the biological sample by comparing the intrinsic physical value for at least one unknown nucleic acid to an intrinsic physical value for a known nucleic acid. | 06-26-2014 |
20140180601 | ANALYSIS SYSTEM FOR ANALYZING BIOLOGICAL SAMPLES WITH MULTIPLE OPERATING ENVIRONMENTS - An analysis system for biological samples is disclosed that includes at least one analyzer with an analytical unit for analyzing the biological samples and an analyzer controller. The analysis system further includes an analyzer data management system (ADMS) operable for receiving a selection of an operating environment chosen from multiple operating environments. In some embodiments, an analytical system is provided which offers a switch between sample testing and software validation on the same hardware, thereby offering efficiency and flexibility. For example, if sample testing is typically restricted to a particular time of the day (e.g., blood banks often get their samples in the evening and conduct the sample testing at night), the daytime hours can be used to validate new software. In such a case, additional instruments for software validation are not required and expensive idle times of analytical systems are reduced. | 06-26-2014 |
20140180602 | DETERMINATION OF COPY NUMBER VARIATIONS USING BINOMIAL PROBABILITY CALCULATIONS - This invention relates to a binomial calculation of copy number of data obtained from a mixed sample having a first source and a second source. | 06-26-2014 |
20140188396 | OLIGOMER SEQUENCES MAPPING - Mapping oligomer sequences includes receiving a set of related oligomer sequences, applying one or more key patterns derived from a set of oligomer sequence relationships to obtain one or more keys that are consistent with the set of related oligomer sequences, and locating the one or more keys in an index configured to map a plurality of possible keys to their respective candidate and/or validated locations in a reference. | 07-03-2014 |
20140188397 | Methods of acquiring genome size and error - Provided is a method of acquiring genome size. The method comprises steps of sequencing random fragments of whole genome, acquiring all of k-mer information including k-mer depth, counting frequency of each k-mer depth value so as to determine expected k-mer depth, and acquiring the genome size by dividing the sum of k-mers by the expected k-mer depth. The method is convenient, rapid, and cost-effective. Also provided is a method of acquiring error of sequencing genome based on all of k-mer information including k-mer depth. | 07-03-2014 |
20140188398 | REMOTE MONITORING OF ANALYTE MEASUREMENTS - Methods and apparatus, including computer program products, are provided for remote monitoring. In some example implementations, there is provided a method. The method may include receiving, at a remote monitor, a notification message representative of an event detected, by a server, from analyte sensor data obtained from a receiver monitoring an analyte state of a host; presenting, at the remote monitor, the notification message to activate the remote monitor, wherein the remote monitor is configured by the server to receive the notification message to augment the receiver monitoring of the analyte state of the host; accessing, by the remote monitor, the server, in response to the presenting of the notification message; and receiving, in response to the accessing, information including at least the analyte sensor data. Related systems, methods, and articles of manufacture are also disclosed. | 07-03-2014 |
20140188399 | ELECTRONIC ALCOHOL INTOXICATION DETECTION, IDENTIFICATION AND SUBSCRIBER NOTIFICATION SYSTEM - An electronic alcohol intoxication detection, identification and subscriber notification system may include a device that may include an enclosure having an interior housing and an exterior. The enclosure houses components indentifying intoxication level data. A remote database may wirelessly connect to the intoxication level data. A virtual server may than transmit the intoxication level data in the form of notifications to at least one contact point of a subject. | 07-03-2014 |
20140188400 | ANALYSIS OF GLUCOSE MEDIAN, VARIABILITY, AND HYPOGLYCEMIA RISK FOR THERAPY GUIDANCE - A system and method to provide guidance for diabetes therapy includes determining glycemic risks based on an analysis of glucose data. The analysis includes visualization of a glucose median, the variability of glucose in a patient, and the risk of hypoglycemia. An Advanced Daily Patterns report includes a visualization of an ambulatory glucose profile and a glucose control measure. The glucose control measure provides a highly visible and understandable display of the glucose condition of a patient visually expressed in the categories of low glucose, median glucose, and glucose variability. | 07-03-2014 |
20140188401 | DETERMINATION OF COPY NUMBER VARIATIONS USING BINOMIAL PROBABILITY CALCULATIONS - This invention relates to a binomial calculation of copy number of data obtained from a mixed sample having a first source and a second source. | 07-03-2014 |
20140195163 | PROCESSING OF SKIN CONDUCTANCE SIGNALS TO MITIGATE NOISE AND DETECT SIGNAL FEATURES - Methods, systems, and devices are described for identifying noisy regions in a skin conductance signal. The signal is divided into a plurality of windows. Two or more features of the signal within a first window are computed. At least one of the two or more features being in a frequency domain. At least two of the features are combined to obtain at least a first metric. The first metric is compared to a corresponding threshold. The first window is identified as a noisy region of the skin conductance signal based on the comparison. | 07-10-2014 |
20140195164 | NONINVASIVE PRENATAL MOLECULAR KARYOTYPING FROM MATERNAL PLASMA - Disclosed herein are methods, systems, and apparatus for detecting microamplifications or microdeletions in the genome of a fetus. In some embodiments, the method comprises receiving sequence tags for each of a plurality of DNA fragments in a biological sample; determining genomic positions for the sequence tags; determining whether the density of DNA in each of a plurality of genomic regions is aberrantly high or low; identifying as a microamplification a set of consecutive genomic regions having aberrantly high density; and identifying as a microdeletion a set of consecutive genomic regions having aberrantly low density. The biological sample may be a blood sample obtained noninvasively from a female subject pregnant with the fetus. | 07-10-2014 |
20140195165 | SYSTEMS AND METHODS FOR IDENTIFYING THE RELATIONSHIPS BETWEEN A PLURALITY OF GENES - The present invention relates to a method and system for the evaluation of differential dependencies of a set of discrete random variables between two conditions. In some embodiments, the system and method compares two conditions by evaluating the probability distributions of the likely dependency networks from random variables. | 07-10-2014 |
20140195166 | DEVICE CONTROL USING SENSORY INPUT - Techniques for device control using sensory input are described, including receiving input from one or more sensors coupled to a wearable computing device, processing the input to determine a pattern, the pattern associated with a social network, and generating a control signal based on the input, the control signal configured to initiate execution of a social-related activity on the social network. | 07-10-2014 |
20140195167 | METHOD FOR EVALUATING THE AMOUNT OF TRITIUM ABSORBED BY A PERSON AFTER EXPOSURE TO AN ENVIRONMENT CONTAINING TRITIUM WITHOUT DRAWING BODY FLUID - The invention relates to a method of estimating the tritium dose absorbed by a person exposed to an environment with a tritium atmosphere. | 07-10-2014 |
20140195168 | CONSTRUCTING A DIFFERENTIAL DIAGNOSIS AND DISEASE RANKING IN A LIST OF DIFFERENTIAL DIAGNOSIS - Disclosed is a system and method for developing a differential diagnosis list or disease ranking in a list of differential diagnosis or identifying a unique disease process when the etiology of patient's presentation is unknown. In one example, the method receive one or more symptoms of a patient, determines a set of diseases having at least one clinical feature that overlaps with the patient's symptoms, determines a ratio of prevalence for each respective disease to a cumulative prevalence of the set of diseases, determines a respective relative probability score for each disease of the set of diseases in view of the ratio of prevalence, determines a ranking of the diseases of the set of diseases in view of the relative probability scores, and outputs the ranking of the diseases. | 07-10-2014 |
20140195169 | APPARATUS FOR ESTIMATING BODILY INJURY LEVEL OF VEHICLE OCCUPANT - The present disclosure relates to an apparatus for estimating level of bodily injury of occupants at an accident of a vehicle. The apparatus has an occupancy detecting block which determines occupied seat. The apparatus has a deformation estimating block which estimates a deformation amount which is reduction of space around the seat. The apparatus has a bodily injury estimating block which estimates bodily injury level based on the occupied seat and estimated deformation amount. | 07-10-2014 |
20140195170 | APPARATUS, SYSTEM AND METHODS FOR ASSESSING DRUG EFFICACY USING HOLISTIC ANALYSIS AND VISUALIZATION OF PHARMACOLOGICAL DATA - Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example method includes a computer-implemented method for assessing drug efficacy, comprising: accessing a first data set related to the performance of a target drug for a given indication; accessing a second data set related to a control for the indication; comparing the data for the target drug and the data for the control on at least one of a plurality of different metrics using a holistic analysis, wherein the at least one metric corresponds to an outcome associated with the indication and generating a corresponding report. An example apparatus/system includes a holistic analysis and viewing system to support the assessment of drug efficacy, said system comprising: a standardizer to at least one of standardize and normalize data related to drug development; a deviation analyzer to analyze said data based on at least one of a plurality of different efficacy metrics, wherein a quantified variation between a first data set of results corresponding to an identified target drug and a second data set of results corresponding to a control, wherein said first data set of results is provided for comparison with the second data set of results and the deviation therebetween is compared to the at least one efficacy metric. | 07-10-2014 |
20140200821 | NON-PARAMETRIC METHODS FOR MASS SPECTROMIC RELATIVE QUANTIFICATION AND ANALYTE DIFFERENTIAL ABUNDANCE DETECTION - A method of normalizing data can comprise globally normalizing at least a first and second data distribution by normalizing the proximal compositional proportionality of the abundance of the analyte using proximity-based intensity normalization. In an example, the proximity-based intensity normalization comprising using the following formula: | 07-17-2014 |
20140200822 | WAVE FRONT DETECTION FOR ELECTROPHYSIOLOGICAL SIGNALS - A method to calculate and visualize dynamic wave front propagation of electrical signals on a geometric surface is described. Wave front locations are identified on the geometric surface between each identified pair of adjacent nodes on the geometric surface. A graphical map can be generated to represent the identified wave front locations on at least a portion of the geometric surface. | 07-17-2014 |
20140200823 | NON-LOCAL MEAN FILTERING FOR ELECTROPHYSIOLOGICAL SIGNALS - A method can include storing input electrical signal data representing at least a given electrophysiological signal acquired from a patient. A non-local mean filter can be applied to the given electrophysiological signal, the non-local mean filter including a spatial filter component and an intensity filter component. The method can also include controlling parameters to establish weighting of each of the spatial filter component and the intensity filter component in response to a control input. Filtered signal data can be stored based on the applying and the controlling. | 07-17-2014 |
20140200824 | K-PARTITE GRAPH BASED FORMALISM FOR CHARACTERIZATION OF COMPLEX PHENOTYPES IN CLINICAL DATA ANALYSES AND DISEASE OUTCOME PROGNOSIS - Systems and methods are disclosed that can analyze relationships between parameters in data matrices (e.g., collections of individual profiles). A graph topology can be defined on a data matrix with partitions as variables and vertices in all partitions and their potentials and edges as the co-occurrence of a pair of variable values in a profile. Individual graphs can be constructed from data and value co-occurrences for every profile, and a study data graph made as a union of all individual graphs. Heterogeneity Landmarks (HLs) can be determined from the study data graph, and graph-graph distances between individual graphs and all HLs. These distances can be used for prognoses based on similarity of a profile to one or more HLs. | 07-17-2014 |
20140200825 | Method for predicting whether a cancer patient will not benefit from platinum-based chemotherapy agents - A testing method for identification whether a cancer patient is a member of a group or class of cancer patients that are not likely to benefit from administration of a platinum-based chemotherapy agent, e.g., cisplatin, carboplatin or analogs thereof, either alone or in combination with other non-platinum chemotherapy agents, e.g., gemcitabine and paclitaxel. This identification can be made in advance of treatment. The method uses a mass spectrometer obtaining a mass spectrum of a blood-based sample from the patient, and a computer operating as a classifier and using a stored training set comprising class-labeled spectra from other cancer patients. | 07-17-2014 |
20140200826 | Methods For Inflammatory Disease Management - Quantitative datasets are created and used in the identification, monitoring and treatment of disease states and characterization of biological conditions. | 07-17-2014 |
20140207384 | Method and System for Transferring Analyte Test Data - A system for transferring data includes an analyte test instrument (ATI) adapted to store data, a wirelessly enabled data management device (DMD) for comprehensively analyzing data, and an adaptor removably connected to the ATI for transferring data stored on the ATI to the DMD. The adaptor includes a data communication device capable of removable connection with the ATI, a microprocessor electrically connected to the data communication device, a wireless controller electrically connected to the microprocessor and a wireless transceiver electrically connected to the wireless controller. In use, data transfer is executed between the ATI and the DMD by electrically and mechanically connecting the adaptor to the ATI. Data stored on the ATI is then automatically downloaded into adaptor memory. Upon completion of the download, the user activates an externally accessible input device on the adaptor which, in turn, wirelessly transmits data from the adaptor memory to the DMD. | 07-24-2014 |
20140207385 | SYSTEMS AND METHODS FOR CHARACTERIZING TOPOLOGICAL NETWORK PERTURBATIONS - Systems, computerized methods and products are disclosed herein for determining metrics for nodes in a network model of a biological system. Such systems and computerized methods can be used to quantify the response of a biological system to one or more perturbations based on measured activity data of a subset of entities in the biological system. Based on the activity data and a network model of the biological system, centrality values representative of the relative importance of a node in the network are derived. The centrality values are used for characterizing topological perturbations in the network, such as for performing sensitivity analysis, visualizing topological effects of a perturbation in the biological system, or deriving a score quantifying the response of the biological system to a perturbation such as exposure to a chemical agent. | 07-24-2014 |
20140214329 | SYSTEM AND METHOD FOR ANALYZING UNI- OR MULTI-VARIATE DATASETS - A system and method for analyzing a plurality of datasets acquired from a plurality of data sources includes identifying at least one descriptor common to the datasets. The method also includes using the at least one descriptor to calculate intra-data-source signed matrices and generating a similarity matrix based on the intra-data-source signed matrices. The method further includes analyzing an alignment of the data-sources using the similarity matrix and at least one analysis metric and generating a report indicating at least a similarity of the data sources. | 07-31-2014 |
20140214330 | LOW POWER MONITORING SYSTEMS AND METHOD - The present disclosure relates to systems and methods for collecting patient data via a monitoring system, with reduced power consumption. In one embodiment, the monitoring system is configured to emit pulses of light, and detect the light after passing through patient tissue. The light data is emitted sporadically, and a waveform is reconstructed from the sporadically sampled light data. Physiological parameters from the patient may be calculated from the reconstructed waveform. The sporadic sampling may reduce the power consumption by the monitoring system. | 07-31-2014 |
20140214331 | COMPUTER-IMPLEMENTED METHOD AND SYSTEM FOR DETECTING INTERACTING DNA LOCI - A computer method of detecting interacting DNA loci by constructing a contingency table from samples of a first trait and samples of a second trait. The samples of the first and second trait are associated with one of a plurality of genotype calls, each relating to an interaction between multiple DNA loci. The contingency table includes frequencies of each genotype call in the samples. Based on the contingency table, measuring the association between the plurality of genotype calls and the first and second traits. Classifying the genotype calls into a first group that is statistically associated with the first trait and a second group that is statistically associated with the second trait. | 07-31-2014 |
20140214332 | SYSTEM AND METHOD FOR RECOMBINATION OF GENOME SEQUENCE CONSIDERING READ LENGTH - There are provided an apparatus for recombining genome sequence in consideration of a read length, and a method thereof. An exemplary embodiment of the sequence recombination apparatus includes a seed length calculating unit configured to calculate a seed length based on a read length of an input read, a seed generating unit configured to generate at least one seed having the seed length from the read, and an alignment unit configured to perform global alignment operation on a reference sequence of the read using the generated seed. | 07-31-2014 |
20140214333 | SYSTEM AND METHOD FOR GENOMIC DATA PROCESSING WITH AN IN-MEMORY DATABASE SYSTEM AND REAL-TIME ANALYSIS - A system and a method for analyzing and evaluating genome data in the course of personalized medicine. In-memory technology is provided for processing of genome data and its real-time analysis as a holistic process in the course of personalized medicine. The cloud application helps physicians and researchers to identify the genetic roots for certain tumor types in the treatment of diseases correlating to genomic variants or mutations, such as cancer diseases. The system combines the latest international research results with patient-specific genomic data while eliminating the need for long-lasting manual searches of all dispositions in distributed international research and literature data sources. | 07-31-2014 |
20140214334 | EFFICIENT GENOMIC READ ALIGNMENT IN AN IN-MEMORY DATABASE - A high performance, low-cost, gapped read alignment algorithm is disclosed that produces high quality alignments of a complete human genome in a few minutes. Additionally, the algorithm is more than an order of magnitude faster than previous approaches using a low-cost workstation. The results are obtained via careful algorithm engineering of the seeding based approach. The use of non-hashed seeds in combination with techniques from search engine ranking achieves fast cache-efficient processing. The algorithm can also be efficiently parallelized. Integration into an in-memory database infrastructure (IMDB) leads to low overhead for data management and further analysis. | 07-31-2014 |
20140214335 | SHORT IMAGERY TASK (SIT) RESEARCH METHOD - The present invention relates to biologically and behaviorally based methods of measuring audience response to a short stimulus. | 07-31-2014 |
20140214336 | SYSTEMS AND METHODS FOR NETWORK-BASED BIOLOGICAL ACTIVITY ASSESSMENT - Systems and methods are disclosed herein for quantifying the response of a biological system to one or more perturbations based on measured activity data from a subset of the entities in the biological system. Based on the activity data and a network model of the biological system that describes the relationships between measured and non-measured entities, activities of entities that are not measured are inferred. The inferred activities are used for deriving a score quantifying the response of the biological system to a perturbation such as a response to a treatment condition. The score may be representative of the magnitude and topological distribution of the response of the network to the perturbation. | 07-31-2014 |
20140222348 | Mass Spectrometry - The present invention is concerned with methods for the de novo sequencing of polypeptides from data obtained from mass spectrometry devices, particularly from (MS) | 08-07-2014 |
20140222349 | System and Methods for Pharmacogenomic Classification - The invention provides a system and methods for the determination of the pharmacogenomic phenotype of any individual or group of individuals, ideally classified to a discrete, specific and defined pharmacogenomic population(s) using machine learning and population structure. Specifically, the invention provides a system that integrates several subsystems, including (1) a system to classify an individual as to pharmacogenomic cohort status using properties of underlying structural elements of the human population based on differences in the variations of specific genes that encode proteins and enzymes involved in the absorption, distribution, metabolism and excretion (ADME) of drugs and xenobiotics, (2) the use of a pre-trained learning machine for classification of a set of electronic health records (EHRs) as to pharmacogenomic phenotype in lieu of genotype data contained in the set of EHRs, (3) a system for prediction of pharmacological risk within an inpatient setting using the system of the invention, (4) a method of drug discovery and development using pattern-matching of previous drugs based on pharmacogenomic phenotype population clusters, and (5) a method to build an optimal pharmacogenomics knowledge base through derivatives of private databases contained in pharmaceutical companies, biotechnology companies and academic research centers without the risk of exposing raw data contained in such databases. Embodiments include pharmacogenomic decision support for an individual patient in an inpatient setting, and optimization of clinical cohorts based on pharmacogenomic phenotype for clinical trials in drug development. | 08-07-2014 |
20140222350 | ELECTROCARDIOGRAM BASELINE REMOVAL - A system includes a low pass-filter and a Savitzky-Golay filter. The low-pass filter receives and processes a first electrocardiogram signal. The filter removes at least the high frequency components of the first electrocardiogram signal. The Savitzky-Golay filter estimates a baseline variation of the first electrocardiogram signal from the filtered first electrocardiogram signal. Related apparatus, systems, techniques and articles are also described. | 08-07-2014 |
20140222351 | DEVICE AND METHOD TO ASSIST TREATMENT OF THE CORNEA - A method and device for assisting treatment of the cornea, the device including a memory ( | 08-07-2014 |
20140236488 | Computed Tomography Calibration Systems and Methods - According to certain embodiments of the invention, computer hardware and software can perform single or dual-energy decomposition calculations and predict CT values for either single-energy or dual energy CT from basis material decomposition estimates derived using theoretical models. Using that information, the computer hardware and software can (among other things) present one dimensional information from a CT scanner, such as representative pixel value, in two dimensions, such as a line in two dimensional basis material space. | 08-21-2014 |
20140236489 | BLOOD GLUCOSE MEASURING KIT CONNECTABLE TO MOBILE DEVICE - A blood glucose measuring kit connectable to a mobile device is configured to display blood glucose data via the screen of an external mobile device, with a view to reducing the production cost of the measuring kit. The measuring kit includes a housing provided therein with a control unit, a test strip receiver, and a data transfer port. The control unit generates blood glucose data by testing a blood glucose test strip with the test strip receiver and outputs a blood glucose test completion signal. The data transfer port is electrically connected to the mobile device and transfers the blood glucose data thereto. Using a signal processing program downloaded wirelessly from the Internet, the mobile device reads, analyzes, applies statistics to, and stores the blood glucose data, displays the blood glucose data on its screen, and can upload and download the blood glucose data wirelessly to and from the Internet. | 08-21-2014 |
20140236490 | BIOINFORMATICS SYSTEMS, APPARATUSES, AND METHODS EXECUTED ON AN INTEGRATED CIRCUIT PROCESSING PLATFORM - A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. Each subset of the hardwired digital logic circuits is formed in a wired configuration to perform the one or more steps in the sequence analysis pipeline. | 08-21-2014 |
20140236491 | Methods For Indirect Determination of Reference Intervals - The invention relates to methods for indirectly determining clinical laboratory reference intervals. In one aspect, a reference interval is determined using all measurements for a given analyte stored in a large existing database. In other aspects, a characteristic of a subject is used to select a reference population for inclusion in reference interval calculations. In other aspects, the invention provides methods for changing treatment plan, diagnosis, or prognosis for an individual subject based on differences between the new reference interval and a previously utilized reference interval. In other aspects, the invention provides systems and computer readable media for indirectly determining reference intervals. | 08-21-2014 |
20140236492 | METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW - Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. | 08-21-2014 |
20140236493 | Methods, Systems and Devices for Activity Tracking Device Data Synchronization With Computing Devices - Methods, devices and system are provided. One method includes capturing activity data associated with activity of a user via a device. The activity data is captured over time, and the activity data is quantifiable by a plurality of metrics. The method includes storing the activity data in storage of the device and, from time to time, connecting the device with a computing device over a wireless communication link. The method defines using a first transfer rate for transferring activity data captured and stored over a period of time. The first transfer rate is used following startup of an activity tracking application on the computing device The method also defines using a second transfer rate for transferring activity data from the device to the computing device for display of the activity data in substantial-real time on the computing device. | 08-21-2014 |
20140236494 | MULTI-PARAMETER THROMBOTIC ASSAY APPARATUS, SYSTEMS, AND METHODS - Apparatus, systems, and methods are provided for assessing clot activity in blood under various conditions in vitro. The apparatus includes a plurality of test receptacles that receive the blood, at least one flow generating mechanism in communication with the test receptacles, and a clot detector configured to analyze an amount of clot formation that occurs within the blood in each receptacle. Blood contacting surfaces of a first subset of the test receptacles are coated with a first surface substrate and blood contacting surfaces of a second subset of the test receptacles are coated with a different second surface substrate. The flow generating mechanism is configured to generate a first blood flow rate through a third subset of the test receptacles and to generate a different second blood flow rate through a fourth subset of the test receptacles. | 08-21-2014 |
20140236495 | PATIENT STRATIFICATION AND DETERMINING CLINICAL OUTCOME FOR CANCER PATIENTS - In a first aspect the present invention is directed to a method of generating a scheme allowing classification of a cancer of an individual patient for estimating a clinical outcome for said patient. It also refers to a method of estimating a clinical outcome of a patient suffering from epithelial ovarian cancer (EOC). The present invention also refers to a method of determining whether the epithelial mesenchymal score of a patient suffering from a cancer can be changed by administering an EMT reversal agent to increase patients susceptibility for an anti-cancer treatment. | 08-21-2014 |
20140236496 | Methods and Systems for Visualizing and Evaluating Data - A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting a first set of emission data from a plurality of samples, each included in a sample region of a plurality of sample regions, at a first time during an amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data. A dPCR result is generated based on the positive or negative amplification determinations for the plurality of samples. | 08-21-2014 |
20140244180 | SHAPE ANALYSIS AND MASS SPECTROMETRY OF INDIVIDUAL MOLECULES BY NANOMECHANICAL SYSTEMS - The spatial distribution of mass within an individual analyte can be imaged—in real time and with molecular-scale resolution—when it adsorbs onto a nanomechanical resonator. Each single-molecule adsorption event induces discrete, time-correlated perturbations to the modal frequencies of the device. By continuous monitoring of multiple vibrational modes, the spatial moments of mass distribution can be deduced for individual analytes, one-by-one, as they adsorb. This new method was validated for inertial imaging using both experimental multimode frequency-shift data and finite-element simulations—to analyze the inertial mass, position-of-adsorption, and the shape of individual analytes. Unlike conventional imaging, the spatial resolution of nanomechanical inertial imaging is not limited by wavelength-dependent diffraction phenomena; instead frequency fluctuation processes determine the ultimate attainable resolution. Advanced NEMS devices can provide atomic-scale resolution. | 08-28-2014 |
20140244181 | SYSTEM AND METHOD FOR ESTIMATING GLUCOSE IN PLASMA - A plasma glucose estimation system is provided comprising a sensor which generates a signal from a glucose concentration measured in a medium, filtering means and a glycemic estimator. Also a method comprising: i) generating a signal which represents the glucose concentration measured in the medium; ii) filtering the signal generated; iii) applying a set of local estimation models, to the previous signal, obtaining a set of local plasma glucose estimates; iv) applying a weighting to each one of the local estimates previously obtained; v) estimating a plasma glucose concentration by the sum of the weighted local estimates obtained in the previous step; vi) correcting the signal obtained from the previous step from reference glycemia measurements and obtaining the final plasma glucose estimate. | 08-28-2014 |
20140244182 | MOLECULAR PROFILING OF TUMORS - Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | 08-28-2014 |
20140244183 | MOLECULAR PROFILING OF TUMORS - Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | 08-28-2014 |
20140244184 | System and Method for Biologic Particle Density Path Projection - A processing method is disclosed for projecting one or more biologic particle density paths and for defining at least one retesting time for a specific biologic particle density of a patient. The processor is programmed to process laboratory data from the patient or from a data repository. The processor identifies a pattern of a plurality of biologic particle densities and based on at least the pattern identifies a medical condition and calculates a potential worst case pattern or trajectory of the laboratory test value over time based on the pattern and/or the identified medical condition. The system may calculate or identify the retesting time based on at least the minimum change of the parameter which would have actionable clinical relevance. | 08-28-2014 |
20140249760 | MONITORING SYSTEM AND DEVICE WITH SENSORS THAT ARE RESPONSIVE TO SKIN PIGMENTATION - A system is provided for using data based on user habit information or user monitoring. A monitoring device has one or more sensors that detect or measure user information selected from of at least one of, a user's activities, behaviors and habit information, and a user's health. The monitoring device includes circuitry that provides at least identification of the monitoring device, a communication system which reads and transmits an identification of the monitoring device, and a pathway system. A telemetry system is provided with a database of user ID's and is in communication with the monitoring device. A device determines a user's melanin level at a place where the monitoring device is positioned on the user. The user's melanin level is used with monitoring or measuring information relative to the user. | 09-04-2014 |
20140249761 | CHARACTERIZING UNCHARACTERIZED GENETIC MUTATIONS - An ensemble predictor for characterizing uncharacterized genetic mutations is disclosed. A first set of genomic information representing a particular (e.g., harmful) mutation is obtained. The first set of genomic information is provided to a number of underlying mutation impact predictors. Predictions are obtained from the underlying predictors. The predictions predict whether the first set of genomic information represents the particular mutation. The predictions and the particular (known) mutation are provided to a logistic regression model, which provides a coefficient for each underlying predictor. A second set of (uncharacterized) genomic information is obtained. The second set of genomic information is provided to the underlying predictors. Predictions are obtained from the underlying predictors and are then weighted using the coefficients. A characterization (e.g., as harmful or not) of the second set of genomic information is provided by the ensemble predictor based on the weighted underlying predictions and may be displayed. | 09-04-2014 |
20140249762 | GENOMIC TENSOR ANALYSIS FOR MEDICAL ASSESSMENT AND PREDICTION - Systems and methods are described for medical characterization of biological data. One such method includes applying a decomposition algorithm, by a processor, to an Nth-order tensor representing data, wherein N≧2, to generate, from at least two submatrices A and B of the tensor, eigenvectors of each of AA | 09-04-2014 |
20140249763 | MOBILE DEVICE - A mobile device including a biosensor for obtaining biological signals in which biological information can be obtained stably while the mobile device is being held with a hand and is used, without providing a sensor specially used for detecting body motion generated by operating the mobile device. | 09-04-2014 |
20140257708 | DIAGNOSING AND MONITORING DEPRESSION DISORDERS - Materials and methods related to developing a disease score for a depression disorder (e.g., unipolar depression or major depressive disorder) in a subject using a multi-parameter system to measure a plurality of parameters, and an algorithm to calculate the score. The materials and methods can be used to, for example, diagnose depression disorders, or determine a subject's predisposition to develop a depression disorder. The methods also can include using a multi-parameter hypermapping system and algorithms related thereto. | 09-11-2014 |
20140257709 | BIOMETRIC MONITORING DEVICE HAVING A BODY WEIGHT SENSOR, AND METHODS OF OPERATING SAME - A system comprising a biometric monitoring device including a housing including a platform to receive at least one foot of the user, a body weight sensor to generate body weight data, processing circuitry to calculate user weight data which corresponds to the user's weight, using the body weight data, and communication circuitry to: (a) receive user identification data which identifies the user or a portable activity monitoring device, and (b) transmit the user weight data to data storage associated with the user identification data. The system further includes the portable activity monitoring device including a housing having a physical size and shape that is adapted to couple to the user's body, a sensor to generate sensor data, and communication circuitry to receive physiologic data which is based on the user weight data, and processing circuitry to calculate activity data using the sensor data and physiologic data. | 09-11-2014 |
20140278121 | SYSTEMS AND METHODS FOR NETWORK-BASED CALCULATION AND REPORTING OF METABOLIC RISK - Systems and methods are provided for generating metabolic risk reports using a Beta Cell Responsiveness Score. A model for calculation of a Beta Cell Responsiveness Score is generated using a sample population. The Beta Cell Responsiveness Score may measure the appropriateness of an individual's beta cell insulin production in light of the individual's insulin resistance in such a way that it is understandable and clinically relevant. This may increase individuals' compliance with treatment recommendations and allow clinicians to more accurately assess where an individual's metabolic function lies along the spectrum of normal to pre-diabetic to diabetic. | 09-18-2014 |
20140278122 | Infusion Management Platform with Infusion Data Grouping Logic - An infusion management platform can determine, based on one or more infusion events, whether to group infusions or segments of infusions. Related apparatus, systems, techniques and articles are also described. | 09-18-2014 |
20140278123 | Method for the Detection and Handling of Hypoglycemia - A method is described herein to detect and treat hypoglycemia. An example of this method involves the detection of hypoglycemia in a patient with a computing device, computation of a recommended carbohydrate amount to ingest by the patient with the computing device in response to said detecting the hypoglycemia, output of the recommended carbohydrate amount with the computing device, and the performance of a hypoglycemia surveillance with the computing device to determine whether the recommended carbohydrate amount remedied the hypoglycemia. | 09-18-2014 |
20140278124 | System and Methods for Analyzing Blood Glucose Data and Quantifying the Success or Failure of Insulin Therapy - A system and technique are enclosed for determining the effectiveness of a blood glucose therapy treatment. Examples of this technique include analyzing sufficiency of blood glucose data collected from a patient with a computing device, analyzing hypoglycemic risk based on the blood glucose data with the computing device, analyzing glycemic control for the blood glucose data with the computing device, analyzing glycemic variability of the blood glucose data with the computing device, and outputting results from said analyzing the sufficiency, said analyzing the hypoglycemic risk, said analyzing the glycemic control, and said analyzing the glycemic variability with the computing device. | 09-18-2014 |
20140278125 | Apparel and Location Information System - Systems and methods are provided for calculating athletic activity parameters. Multiple housings are position at different locations on a user's body. The housings are configured to be removably engaged with an electronic module that includes a sensor and a processor configured to calculate athletic activity parameters. Each housing is connected to or includes an identification memory that stores information identifying a location of the housing. The electronic module uses the location information to select an algorithm to use when calculating the athletic activity parameters. | 09-18-2014 |
20140278126 | High-Resolution Melt Curve Classification Using Neural Networks - The present invention relates to a method and system for classifying high-resolution melt (“HRM”) curves, and, more specifically, to a method and system for classifying HRM curves by genotype where the curves are represented by a mathematical function with varying coefficient values. | 09-18-2014 |
20140278127 | Computer Files and Methods Supporting Forensic Analysis of Nucleotide Sequence Data - In one illustrative embodiment, a method may comprise receiving a first text-based computer file including one or more records, each of the one or more records comprising nucleotide sequence data generated by a read of a massively parallel sequencing (MPS) instrument, determining whether a portion of the nucleotide sequence data of each record represents a short tandem repeat (STR) associated with a locus, placing each portion of the nucleotide sequence data determined to represent an STR associated with a locus into one of a number of locus-specific lists, determining a number of occurrences within each locus-specific list of identical nucleotide sequence data representing a unique STR, and generating a second text-based computer file including one or more records, each of the one or more records corresponding to a unique STR for which the number of occurrences of identical nucleotide sequence data representing the unique STR exceeded an abundance threshold. | 09-18-2014 |
20140278128 | Combining RNAi Imaging Data With Genomic Data For Gene Interaction Network Construction - Embodiments of the invention relate to a method, system, and computer program product to construct a gene interaction network by combining two sources of genomic information, namely RNAi imaging data and gene expression data. Tools are provided to gather data, including gene expression data and gene image data, and to compute measurements and relationships, respectively. A graph is constructed with nodes representing genes and edges drawn between the nodes to form gene clusters. The graph is refined such that the shape captures a structural pattern of the cluster. | 09-18-2014 |
20140278129 | REGULARIZATION SCHEMES FOR NON-CONTACT MAPPING WITH A MEDICAL DEVICE - An embodiment of a method for solving the inverse problem of electrophysiology and determining a voltage distribution on a surface of a tissue may comprise receiving a plurality of voltages collected by a plurality of electrodes adjacent to the surface, discretizing the problem using a Finite Element Method (FEM) or a Boundary Element Method (BEM), introducing one or more regularization terms to an error minimization formulation, and solving, by a processor, the voltage distribution according to the plurality of voltages and according to the regularization terms. The regularization terms may comprise one or more of a Laplacian smoothness operator, a Tikhonov regularization matrix, a confidence matrix, and a linear operator that interpolates the plurality of electrode voltages to the tissue voltage distribution. | 09-18-2014 |
20140278130 | Method of predicting toxicity for chemical compounds - The invention disclosed herewith is a computer-implemented method for evaluating the toxicity of chemical compounds. In particular, some embodiments of the invention comprise importing microarray data representing measurements of the RNA transcription from hepatocytes, and running at least one algorithm (such as a coefficient penalized linear regression algorithm) on the imported data to assess potential adverse drug effects. After the evaluation has been carried out, the results are exported to reports or databases. | 09-18-2014 |
20140278131 | Combining RNAi Imaging Data With Genomic Data For Gene Interaction Network Construction - Embodiments of the invention relate to a method for constructing a gene interaction network by combining two sources of genomic information, namely RNAi imaging data and gene expression data. Tools are provided to gather data, including gene expression data and gene image data, and to compute measurements and relationships, respectively. A graph is constructed with nodes representing genes and edges drawn between the nodes to form gene clusters. The graph is refined such that the shape captures a structural pattern of the cluster. | 09-18-2014 |
20140278132 | Using RNAi Imaging Data For Gene Interaction Network Construction - Embodiments of the invention relate to a constructing a gene interaction network. Tools are provided to compute a gene relationship measure based upon cellular images, and to rank image collections having a similar morphology. The ranking is based upon capturing similarity within the ranked collection by modeling a three dimensional shape of a cellular image stack. The graph is constructed for related images stacks. Nodes in the graph represent genes, and edges drawn between the nodes represent corresponding image stacks in a commonly ranked list. Accordingly, the graphical representation mathematically and visually connects respective genes. | 09-18-2014 |
20140278133 | SYSTEMS AND METHODS FOR DISEASE ASSOCIATED HUMAN GENOMIC VARIANT ANALYSIS AND REPORTING - Systems and methods for disease associated human genomic variant analysis and reporting is disclosed. The systems and methods include receiving and extracting disease related variant information; storing the disease related variant information in a first data structure. Moreover, the system and methods include identifying a plurality of genomic variants and determining one or more probability of disease associated with at least one or more of the plurality of genomic variants. For at least one or more of the plurality of genomic variants that has at least one probability of disease that is greater than a threshold, the systems and methods may also obtain validation of the at least one of the plurality of genomic variants using the validation module. A report may be created to include at least a disease and the likelihood of the disease. | 09-18-2014 |
20140278134 | Conserved Nucleotide Elements In Ribosomal RNA - The present invention relates to a method of determining conserved ribosomal RNA (rRNA) nucleotide motifs that are specific to one domain of life, Eukarya, Bacteria, or Archaea, and degenerate in at least one other domain of life. The invention also relates to a method of determining conserved ribosomal RNA (rRNA) nucleotide motifs that are specific to one subgroup and degenerate in another subgroup within a domain of life or for a subset group within a domain of life. The invention relates to a method of identifying a compound that is a domain-specific or subgroup-specific ribosomal RNA inhibitor. | 09-18-2014 |
20140278135 | ELECTRONIC VARIANT CLASSIFICATION - A computer-implemented method is discussed that includes identifying, by a computer server system, stored electronic data that represents genetic sequencing for one or more genes for individuals in a population of patients who have submitted to genetic sequencing; generating, for each of multiple individuals and from the stored electronic data, probability data for the individuals and probability or weighting data, or both, for relatives of the individuals, the probability data representing likelihoods that a particular person corresponding to the probability data carries a deleterious mutation in a particular gene; and generating a score for a genetic variant, wherein the score is a function of probability or weighting data, or both, for the individuals and for relatives of the individuals, and the score represent a composite probability that a certain variant is a deleterious or benign variant. | 09-18-2014 |
20140278136 | RAPID DETERMINATION OF MICROBIAL GROWTH AND ANTIMICROBIAL SUSCEPTIBILITY - This disclosure is related to systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance. | 09-18-2014 |
20140278137 | DISTANCE MAPS USING MULTIPLE ALIGNMENT CONSENSUS CONSTRUCTION - Techniques for assembly of genetic maps including de novo assembly of distance maps using multiple alignment consensus construction. Multiple map alignment can be performed on a defined bundle of fragment maps corresponding to biomolecule fragments to determine consensus events and corresponding locations. Fragment maps in the bundle can be removed when there is no overhang from the consensus events. When the subset of fragment maps in the bundle is less than a predetermined threshold, one or more additional fragment maps can be added based on fragment signatures, a consensus alignment score, and a pairwise alignment score. Techniques for multiple alignment can include generating a graph with edges and vertices representing each pairwise relation. An ordered set of sets of events best representing a multiple alignment reflecting all pairwise alignments can be generated by repeatedly randomly removing edges and combining vertices to identify a min cut of the graph. | 09-18-2014 |
20140278138 | Family Networks - Described embodiments enable identification of family networks using combinations of DNA analysis and genealogical information. Genealogical data is provided by users of a genealogical research service or collected from other sources and used to create family trees for each user. DNA samples are also received from the users. By analyzing the DNA samples, potential genetic relationships can be identified between some users. Once these DNA-suggested relationships have been identified, common ancestors can be sought in the respective trees of the potentially related users. Where these common ancestors exist, an inference is drawn that the DNA-suggested relationship accurately represents a familial overlap between the individuals in question. People descended from the same common ancestor are each members of a family network. Members of a family network not in a user's tree may be identified for the user, enabling the user to discover additional ancestors that might otherwise have remained unknown. | 09-18-2014 |
20140278139 | MULTIMODE SENSOR DEVICES - The disclosure provides BMDs that have multiple device modes depending on operational conditions of the devices, e.g., motion intensity, device placement, and/or activity type. The device modes are associated with various data processing algorithms. In some embodiments, the BMD is implemented as a wrist-worn or arm-worn device. In some embodiments, methods for tracking physiological metrics using the BMDs are provided. In some embodiments, the process or the BMD applies a time domain analysis on data provided by a sensor of the BMD when the data has a high signal (e.g., high signal-to-noise ratio), and applies a frequency domain analysis on the data when the data has a low signal, which contributes to improved accuracy and speed of biometric data. | 09-18-2014 |
20140278140 | Algorithm for Wireless, Motion and Position-Sensing, Integrating Radiation Sensor Occupational and Environmental Dosimetry - Described is an apparatus, method and machine-readable medium for determining radiation dosages based on a solution vector for each radiation field and an objective function. | 09-18-2014 |
20140288844 | CHARACTERIZATION OF BIOLOGICAL MATERIAL IN A SAMPLE OR ISOLATE USING UNASSEMBLED SEQUENCE INFORMATION, PROBABILISTIC METHODS AND TRAIT-SPECIFIC DATABASE CATALOGS - The present invention relates to systems and methods for the characterization of biological material within a sample or isolate. The characterization may utilize probabilistic methods that compare sequencing information from fragment reads to sequencing information of reference genomic databases and/or trait-specific database catalogs. The characterization may be of the identities and/or relative concentrations or abundance of one or more organisms contained in the sample or isolate. The identification of the organisms may be to the species and/or sub-species and/or strain level with their relative concentrations or abundance. The characterization may additionally or alternatively be of one or more traits (i.e., characteristics) of the biological material contained in the sample or isolate. The characterization of the one or more traits may be with the relative abundance of the traits. | 09-25-2014 |
20140288845 | Technique for Real-Time Removal of Power Line Interference in ECG - A technique for real-time removal of power line interference (PLI) in electrocardiograms (ECG) with sampling rate a relevant integer multiple of the nominal power line frequency (NPLF), comprising band-pass PLI filtering of the ECG, determining expedient weights and weighted Least-Squares parabolic approximating downsampled to the NPLF series of band-pass PLI filtered values. The disclosed technique utilizes only integer arithmetic, includes pre-adjusting for the routine ECG sampling rates, causes negligible ringing and is still accurate in the common occurrences of PLI with deviating from the nominal 60 or 50 Hz frequency and varying amplitude. | 09-25-2014 |
20140288846 | SYSTEM AND METHOD TO IDENTIFY DYSREGULATED PATHWAYS AND RELATED INTERACTIONS - A method can compute a cooperation profile for at least two genes according to a gene expression data set for each of a plurality of genes, the cooperation profile representing cooperation interactions dysregulated in at least one disease. A competition profile for genes according to the gene expression data set, the competition profile representing a competitive interaction between the genes. A redundancy profile can be computed for the at least two genes according to the gene expression data set for each of the genes, the redundancy profile representing a maximum expression for the genes. A dependency profile for the at least two genes can be according to the gene expression data set for each of the genes, the dependency profile representing a minimum expression for the genes. Some of the computed profiles can be analyzed to identify dysregulated interactions between gene pairs and/or dysregulated pathways. | 09-25-2014 |
20140288847 | SYSTEMS AND TECHNIQUES FOR SEGMENTATION OF SEQUENTIAL DATA - An efficient method and associated systems for segmentation of high throughput sequential data, such as genomic datasets. The technique first utilizes dynamic programming to compute the significance for a large number of candidate segments. It then uses tree-based data structures to detect overlapping significant regions and update them simultaneously. Refinement and merging of significant segments are performed at the end to generate the final segmentation. | 09-25-2014 |
20140288848 | METHOD FOR DETERMINING AND PREDICTING PROTEIN AUTONOMOUS FOLDING - Techniques for determining an equilibrium structure of a protein in a predetermined environment, the protein having Ramachandran angles and a known denatured structure, are disclosed. In a preferred embodiment, a method is presented which involves determining a maximum RMS volume of the known denatured structure of the protein and calculating at least one force on the protein in its current structure in the predetermined environment. The net torque resulting from the at least one force for each of the Ramachandran angles of the protein is then determined. Then at least one section of the protein structure on a side of a Ramachandran angle with greatest torque is rotated to form a new structure. A new RMS volume for the new structure is then calculated, and the method is repeated using the new structure. The method ceases when the new RMS volume of the new protein structure is not less than the RMS volume of the starting structure. | 09-25-2014 |
20140288849 | System for Generating a Dynamic Spectral Signature of an Evolving Biologic Distortion - A medical diagnostic system for quantifying at least one perturbation of a concentration of at least one constituent of blood of a patient over time is described herein. In some examples, the system includes a processor programmed to analyze data comprising the concentration, the concentration having a reference range and define a range of perturbed concentration values which is outside the reference range. The processor can also be programmed to divide the range of perturbed concentration values into sequential sub-ranges comprising at least a first sub-range of concentration values and a second sub-range of concentration values, the second sub-range being further away from the reference range than the first sub-range and assign quanta to each sub-range such that the number of quanta assigned to a sub range far away from the reference range is greater than the number of quanta assigned to a sub-range close to the reference range. | 09-25-2014 |
20140288850 | SELF-LEARNING OF PLANT GROWTH STRATEGY IN A GREENHOUSE - A system for monitoring plants in a greenhouse, the system comprising: a plurality of weighing units, the weighing units distributed in the greenhouse, each of the weighing units is attached to a single plant or group of plants and comprising means for weighing the plant or group of plants, the weighing units are trellising from an elevated wire at one end and connected to the top end of the plant or group of plants at the opposite end; a communication network comprising means for communicating the weight of the plant or group of plants from the weighing units to a central unit; and a central unit, the central unit comprising means for receiving, storing, processing and analyzing data received from the weighing units through the communication network. | 09-25-2014 |
20140297194 | GENE SIGNATURES FOR DETECTION OF POTENTIAL HUMAN DISEASES - A process to select signature gene by performing statistical analyses on gene datasets of various types of diseases for identifying signature genes for at least one of the diseases followed by categorizing and establishing gene expression table with the signature genes. The signature genes in the gene expression table are tested and verified by applying additional datasets to finalize and confirm the signature genes. The step of performing the statistical analyses on the gene datasets of various types of diseases further comprising a step of performing a total background normalization (TBN) of a relative gene expression (RGE) ratio then carried a two-tail T-test of the RGE ratios between the various diseases. The step of identifying the signature gene further comprising a step of carrying out a false positive elimination (FPE) by identifying differently expressed genes and removing overlapping genes among different diseases from a list of the signature genes | 10-02-2014 |
20140297195 | Method and Use of Metabolites for the Diagnosis of Inflammatory Brain Injury in Preterm Born Infants - The present invention relates to novel biomarkers for predicting the likelihood of inflammation-related brain injury in preterm born infants, using a plurality of endogenous target metabolites selected from the group consisting of acyl carnitins, diacylphosphatidylcholines, acyl-alkylphosphatidylchoines, lysophosphatidylcholines and amino acids. | 10-02-2014 |
20140297196 | Hardware Acceleration of Short Read Mapping for Genomic and Other Types of Analyses - A scalable FPGA-based solution to the short read mapping problem in DNA sequencing is disclosed which greatly accelerates the task of aligning short length reads to a known reference genome. A representative system comprises one or more memory circuits storing a plurality of short reads and a reference genome sequence; and one or more field programmable gate arrays configured to select a short read; to extract a plurality of seeds from the short read, each seed comprising a genetic subsequence of the short read; for each seed, to determine at least one candidate alignment location (CAL) in the reference genome sequence to form a plurality of CALs; for each CAL, to determine a likelihood of the short read matching the reference genome sequence in the vicinity of the CAL; and to select one or more CALs having the currently greater likelihood of the short read matching the reference genome sequence. | 10-02-2014 |
20140297197 | CALIBRATION CURVE CREATION METHOD, CALIBRATION CURVE CREATION APPARATUS, AND TARGET COMPONENT GAUGING APPARATUS - A calibration curve creation method is capable of performing accurate measurement from a piece of observation data. The calibration curve creation method includes (a) acquiring observation data regarding a plurality of samples of a subject, (b) acquiring the content of a target component in each sample, (c) estimating a plurality of independent components at the time of separation into a plurality of independent components of each sample and calculating a mixing coefficient corresponding to the target component for each sample, and (d) calculating the regression equation of the calibration curve. The process (c) includes a step of calculating an independent component matrix by executing first pre-processing including correcting the observation data, second pre-processing including whitening, and independent component analysis processing in this order. A process suitable for the observation data is selected from a plurality of processes, and is used as the first pre-processing and the second pre-processing. | 10-02-2014 |
20140297198 | MEASUREMENT SYSTEM - A measurement system includes a measurement device and a multifunctional portable terminal. The a measurement device includes a measurement unit for measuring a particular component in a biological sample, a measurement-side communication unit for transmitting by radio a measurement datum obtained by the measurement unit, and a measurement-side controller for controlling the measurement unit and the measurement-side communication unit. The multifunctional portable terminal includes an output-side communication unit for receiving the measurement datum transmitted from the measurement-side communication unit, an output-side storage unit for storing a plurality of voice message data, an output-side controller for generating a voice message datum or selecting a voice message datum from the voice message data stored in the output-side storage unit based on the measurement datum, and a voice message output unit for outputting the voice message datum generated or selected by the output-side controller. | 10-02-2014 |
20140297199 | DRUG SCREENING METHOD AND USES THEREOF - Described herein are methods of screening drugs in a non-human animal using high resolution technology leading to generation of pharmacomaps. Further described herein are methods of predicting the therapeutic benefit and/or toxicity of drug candidate compounds. In specific embodiments, provided herein are methods of predicting the clinical effects of a test drug based on comparison of the pharmacomap of the test drug to the pharmacomap of one or more reference drugs with known clinical outcomes. | 10-02-2014 |
20140303899 | SYSTEM AND METHOD FOR BIOMETRIC IDENTIFICATION IN A VEHICLE - A computer implemented method for identifying a vehicle occupant including receiving a signal from a plurality of sensors, wherein the signal indicates a measurement of cardiac activity, determining a biomarker based on biometric features of the signal and identifying the vehicle occupant based on the biomarker. | 10-09-2014 |
20140303900 | MOTION PROFILE TEMPLATES AND MOVEMENT LANGUAGES FOR WEARABLE DEVICES - Techniques for determining a state of a user using wearable devices are described, including receiving motion-related data from a first sensor and user-related data from a second sensor over a time period, determining a plurality of states of a user over the time period as a function of the motion-related data and the user-related data, determining a trend as a function of the plurality of states of the user, and displaying information associated with the trend at a user interface. The first sensor and the second sensor may be coupled to a wearable device. The user-related data may include galvanic skin response data. The information associated with the trend may be displayed at a web browser. | 10-09-2014 |
20140303901 | METHOD AND SYSTEM FOR PREDICTING A DISEASE - A method of estimating a likelihood of developing a disease is disclosed. The method comprises obtaining a set of gene sequences corresponding to the disease and a DNA sequence of a subject. The method further comprises, for each gene sequence of the set, searching over the DNA sequence for reoccurrences of the gene sequence, and calculating an average reoccurrence distance between adjacent reoccurrences of the gene sequence. The method further comprises estimating the likelihood of the subject to develop the disease, based on the calculated distances. | 10-09-2014 |
20140303902 | Methods, System, and Medium for Associating Rheumatoid Arthritis Subjects with Cardiovascular Disease - The present invention relates to a system and a medium for analyzing one or more analytes in rheumatoid arthritis subjects to determine whether the subject is at increased risk of diseases such as a cardiovascular disease, the subject's current cardiovascular disease burden, and the likelihood of cardiovascular disease progression in the subject. In addition, the present invention further provides methods for analyzing data to determine risk of cardiovascular disease, current cardiovascular disease burden, and the likelihood of cardiovascular disease progression in a rheumatoid arthritis subject. | 10-09-2014 |
20140309939 | SYSTEMS AND METHODS USING AN INDIVIDUAL'S CONTEXT AND TYPE TO DETERMINE THE INDIVIDUALS STATUS - The methods and systems described herein may involve determining at least one lifeotype of at least one individual, analyzing the at least one lifeotype, and delivering content to at least one individual based on the analysis. The methods and systems described herein may involve providing a game, determining at least one lifeotype of at least one player of the game, analyzing the at least one lifeotype, and affecting the game play based on the analysis. The methods and systems described herein may involve providing an interactive space, determining at least one lifeotype of at least one individual in the space, analyzing the at least one lifeotype, and modifying at least one attribute of the space based on the analysis. | 10-16-2014 |
20140309940 | DETERMINING AN INDIVIDUAL'S MOOD BASED ON THE INDIVIDUAL'S PREDICTED TYPE AND DETECTED DATA - The methods and systems described herein may involve determining at least one lifeotype of at least one individual, analyzing the at least one lifeotype, and delivering content to at least one individual based on the analysis. The methods and systems described herein may involve providing a game, determining at least one lifeotype of at least one player of the game, analyzing the at least one lifeotype, and affecting the game play based on the analysis. The methods and systems described herein may involve providing an interactive space, determining at least one lifeotype of at least one individual in the space, analyzing the at least one lifeotype, and modifying at least one attribute of the space based on the analysis. | 10-16-2014 |
20140309941 | SYSTEM AND APPARATUS FOR PROVIDING BASELINE DATA FOR AUTOMATED PATIENT MANAGEMENT - A system and method for providing baseline data for automated patient management is disclosed. A patient is identified for enrollment in automated patient management with information including at least one of treatment profile and medical history. Device measures are collected to provide raw physiometry for the patient regularly recorded by a medical device, beginning with an initial observation period. Derived device measures are determined to provide derivative physiometry based on the collected device measures. Baseline data from the collected and derived device measures are quantified. | 10-16-2014 |
20140309942 | POLLUTION MONITORING - The effect of pollution in an aquatic mass is monitored. A living sessile organism ( | 10-16-2014 |
20140309943 | SYSTEM AND METHOD FOR THE ANALYSIS OF BIOPOTENTIAL SIGNALS USING MOTION ARTIFACT REMOVAL TECHNIQUES - A system and method for the analysis of biopotential signals using motion artifact removal techniques is disclosed. The system includes a motion classification module configured to receive at least one biopotential signal and at least one reference secondary input signal. The motion classification module performs motion artifact classification for determining motion meta-information, comprising a type and/or severity indication about motion phenomena causing artifacts in the biopotential signal. The motion classification module communicates motion meta-information to a motion artifact reduction module configured to remove motion artifacts from the biopotential signal based on the information received from the motion classification module. The system is further configured to evaluate the effectiveness of at least one algorithm used to remove motion artifacts, and generate feedback information between the motion classification module and the motion artifact reduction module to optimize motion artifact classification. | 10-16-2014 |
20140316710 | METHOD AND APPLICATION FOR DETERMINING AND VISUALLY DEPICTING THE PASSING PROBABILITY OF A MARIJUANA/CANNABIS DRUG TEST - Systems, methods and apparatus are provided through which in some implementations the clinical detectability of THC exposure is accurately estimated. | 10-23-2014 |
20140316711 | Foot orthotic design system - The invention relates to a system for the design of patient-specific orthotics, and particularly approaches the design of patient-specific orthotics upon an assessment of the patient's gait cycle. This enables the practitioner to precisely prescribe a kinetic orthotic that will optimize the way in which force is tranferred during that patient's gait cycle. | 10-23-2014 |
20140316712 | SYSTEM AND METHOD FOR TRACKING FITNESS PROGRESS - The invention is generally a system that enables a user to visually and graphically track their fitness goals using an interactive device connected to a server, wherein fitness progress data of the user is stored and made available to the user via a user interface, for example on a mobile device application or a webpage. The system of tracking fitness progress comprises a server, a database, and a device, for example a fitness booth, for taking images and gathering fitness progress data from a user. The information gathered at the fitness booth, including images, is stored in the database. Users are provided a graphical user interface to update and access their fitness progress data, thereby facilitating the user's tracking of their fitness progress. | 10-23-2014 |
20140316713 | MODULAR BIOMETRIC MONITORING SYSTEM - A modular system for acquiring biometric data includes a plurality of data acquisition modules configured to sample biometric data from at least one respective input channel at a data acquisition rate. A representation of the sampled biometric data is stored in memory of each of the plurality of data acquisition modules. A central control system is in communication with each of the plurality of data acquisition modules through a bus. The central control system is configured to control communication of data, via the bus, with each of the plurality of data acquisition modules. | 10-23-2014 |
20140316714 | METHOD FOR PREDICTING BEEF MARBLING STANDARD (BMS) NUMBERS USING COAT MINERAL COMPOSITION - An object of the present invention is to develop a method for predicting and evaluating the meat quality during the cattle fattening stage and, more particularly, a method by which beef marbling standard (BMS) numbers which determine the price of beef carcasses on the market can be estimated during the cattle fattening stage. | 10-23-2014 |
20140316715 | METHOD OF AUTOMATICALLY SETTING UNIT OF MEASUREMENT OF BIO-DATA MEASURING DEVICE - The present invention relates to a method of automatically setting a unit of measurement of a bio-data measuring device. The bio-data measuring device automatically sets a country belonging to a corresponding location as location information is determined, and automatically selects a unit of measurement of the set country depending on automatic setting for countries. When bio-data is measured by measurement means, operation means calculates a bio-data measurement value depending on a reference unit and a calculation formula, and determines whether the automatically selected unit of measurement of the set country is identical to the reference unit. If the automatically selected unit of measurement is not identical to the reference unit, the operation means converts the calculated bio-data measurement value into a numerical value based on the automatically selected unit of measurement of the set country. The converted numerical value and the automatically selected unit of measurement are displayed. | 10-23-2014 |
20140324359 | PREDICTING THE MOLECULAR COMPLEXITY OF SEQUENCING LIBRARIES - Predicting the molecular complexity of a genomic sequencing library is a critical but difficult problem in modern sequencing applications. Methods to determine how deeply to sequence to achieve complete coverage or to predict the benefits of additional sequencing are lacking. We introduce an empirical Bayesian method to accurately characterize the molecular complexity of a DNA sample for almost any sequencing application based on limited preliminary sequencing. | 10-30-2014 |
20140324360 | ANTI-GCC ANTIBODY MOLECULES AND RELATED COMPOSITIONS AND METHODS - The present invention provides methods for optimization of the harvest process by clarification of cell samples using centrifugation and depth filtration. The present invention provides methods for the determination of the optimal ratio of Q/Σ for the centrifugation step of a harvest process of a cell culture. The present invention provides methods for the determination of the number of particles and the size of the particles in the centrate of a centrifugation step of a harvest process of a cell culture by the use of imaging technology. The present invention provides methods for the scaling of the harvesting process from lab-bench scale to industrial scale. | 10-30-2014 |
20140330524 | TECHNIQUES FOR QUANTIFICATION OF SAMPLES - Techniques are described for quantification of molecules in a sample. Mass spectrometry is performed to obtain ionization intensities for precursor and product ions originating from a particular molecule. A first stet of precursor ions having the highest ionization intensities and originating from the particular molecule is determined. For each of the one or precursors in the first set, determined is a second set of one or more product ions that are fragments associated with said each precursor and have the highest ionization in intensities of product ions associated with said each precursor. An intensity sum is calculated for the particular molecule by adding ionization intensities of product ions included in the second sets for the one or more precursors in the first set. The intensity sum is compared to information included in a calibration standard. A quantity of the particular molecule in the sample is determined based on said comparing. | 11-06-2014 |
20140336941 | SYSTEM AND METHOD FOR ALIGNING GENOME SEQUENCE IN CONSIDERATION OF READ QUALITY - Provided are a system and/or apparatus, and a method, for aligning a genome sequence. The system and/or apparatus includes a corrector configured to correct quality of input reads, a seed generator configured to generate one or more seeds from the corrected reads, and an aligner configured to perform a global alignment operation of the corrected reads in a reference sequence using the generated seeds. | 11-13-2014 |
20140336942 | Analyzing High Dimensional Single Cell Data Using the T-Distributed Stochastic Neighbor Embedding Algorithm - A method for mapping, graphing, and analyzing high-dimensional single cell data based on multiple parameters associated with the cell, including defining a point associated with the cell in a n-dimensional space; combining the point with other points associated with other cells to form a data set; representing the points in the data set in the n-dimensional space; projecting the points in the n-dimensional space onto a lower-dimensional map; and analyzing the features of interest in heterogeneous tissues using the lower-dimensional map. | 11-13-2014 |
20140336943 | SYSTEM AND METHOD FOR MANAGING GENOMIC TESTING RESULTS - Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. In some embodiments, presentation of genomic alteration data is simplified and/or coupled with contextual applications. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations. | 11-13-2014 |
20140336944 | INFORMATION PROCESSING APPARATUS, MOTION IDENTIFYING METHOD, AND RECORDING MEDIUM - The present invention is concerning an information processing apparatus includes a record-information storage unit, a determining unit, a measuring unit, and an identifying unit. The record-information storage unit stores therein an already-identified person's motion together with time. The determining unit determines possible motions that a person can make from the already-identified person's motion. The measuring unit measures measurement information according to a person's motion. The identifying unit performs a pattern detecting process for detecting a pattern similar to the measurement information measured by the measuring unit in patterns corresponding to the possible motions determined by the determining unit out of predetermined patterns of measurement information for person's motions, and identifies a motion corresponding to the detected pattern as a motion that the person made. | 11-13-2014 |
20140336945 | GENE SIGNATURE FOR THE PREDICTION OF RADIATION THERAPY RESPONSE - Described are mathematical models and method, e.g., computer-implemented methods, for predicting tumor sensitivity to radiation therapy, which can be used, e.g., for selecting a treatment for a subject who has a tumor. | 11-13-2014 |
20140336946 | METHOD AND SYSTEM FOR OBTAINING CYCLE OF PHYSIOLOGICAL SIGNAL - The present disclosure provides a method and a system for obtaining a cycle of a physiological signal. The method includes: receiving a physiological signal value and a register value, comparing the physiological signal value with the register value, and reserving one of the physiological signal value and the register value; determining the physiological signal value with a time duration thereof reaching a given set time to be an extreme value; and restarting the procedure and determining a next extreme value; and obtaining a cycle of the physiological signal by calculating a time difference between the extreme value and the next extreme value. In the present disclosure, the cycle of the physiological signal can be obtained by the extreme value recognition algorithm, which is simple, fast, of high efficiency, and of high reliability. | 11-13-2014 |
20140336947 | METHOD AND DEVICE FOR MOBILE TRAINING DATA ACQUISITION AND ANALYSIS OF STRENGTH TRAINING - The invention relates to the field of mobile training data acquisition in sport, particularly in strength training, body building, fitness sports and rehabilitation, as well as the analysis of said training data. The invention involves a method and a mobile device ( | 11-13-2014 |
20140336948 | System and Method for Improving Signal to Noise Ratio for High Frequency Signal Component - An apparatus and method for improving signal to noise ratio of a physiological signal is provided. At least one sensor senses the analog data signal, the analog data signal having a first component including ECG data and a second component including ancillary data. A converter is coupled to the at least one sensor that automatically converts the analog data signal into a digital data signal and decimates the digital data signal from a first sample rate to a second sample rate. A gain compensation circuit is coupled to the converter that automatically measures a magnitude of at least one of the first component and second component of the digital data signal and compares the measured magnitude to a reference value to determine if a gain applied to the analog data signal should be modified and automatically compensates the digital data signal in response to the determination that the analog gain value should be modified, wherein the compensated digital data signal corrects defects associated with a settling period of the converter resulting from modifying the gain applied to the analog data signal. | 11-13-2014 |
20140343860 | HAND-HELD SCANNER SYSTEMS AND METHODS FOR READING POINT OF CARE TEST RESULTS - A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device. | 11-20-2014 |
20140343861 | METABOLIC ENERGY MONITORING SYSTEM - A metabolic energy monitoring system having one or more physiological measurement platforms and displays enabling the calculation and display of energy balance, kilocalorie energy expenditure and kilocalorie intake is described. In preferred embodiments, the system utilizes one or more on-body monitoring platforms to enable measurement of change in body composition and kilocalorie energy expenditure over a period of time thereby enabling a comparator to calculate net energy balance over this period of time and to calculate kilocalorie intake over this same period of time. Such data may then be displayed on a display device in wireless communication with the on-body monitoring platform to provide the user of the system with useful information and guidance in weight management applications. | 11-20-2014 |
20140343862 | Differential Dissociation and Melting Curve Peak Detection - Systems and methods are provided for processing a melting or dissociation curve of a DNA or other sample, for example, during PCR processing. In some embodiments, detection of the melting point and melting curve behavior can be enhanced by taking a derivative of the curve, and detecting peaks in the differential dissociation curve. In some embodiments, the derivative operation can comprise the use of edge-processing, or other detection algorithms. In some embodiments, the dissociation analysis can comprise removing low-frequency (or pedestal) components of the differential dissociation curve. In some embodiments, the differential dissociation curve can exhibit a smoothed or more regular appearance than the raw detected data. | 11-20-2014 |
20140343863 | METHOD FOR EVALUATING VITALITY OF PLANT, AND MEASUREMENT SYSTEM AND EVALUATION SYSTEM - The present invention discloses a method for evaluating vitality of a plant including (a) a step of measuring a delayed luminescence of a leaf of each plant of a group of plants subject to evaluation to obtain data of delayed luminescence amount, and (b) a step of processing data of a plurality of delayed luminescence amounts thus obtained to evaluate a plant exhibiting a delayed luminescence amount not less than a preset upper limit threshold as an individual of poor growth or evaluate a plant exhibiting a delayed luminescence amount not more than a preset lower limit threshold as an individual of good growth, and a measurement system and an evaluation system used for the method. | 11-20-2014 |
20140343864 | METHOD FOR IDENTIFYING MICROORGANISMS VIA MASS SPECTROMETRY AND SCORE NORMALIZATION - An identification by mass spectrometry of a microorganism from among reference microorganisms represented by reference data sets includes: determining a set of data of the microorganism according to a spectrum; for each reference microorganism, calculating a distance between the determined and reference sets; and calculating a probability f(m) according to relation | 11-20-2014 |
20140343865 | Biomarkers for Kidney Cancer and Methods Using the Same - Methods for identifying and evaluating biochemical entities useful as biomarkers for kidney cancer, target identification/validation, and monitoring of drug efficacy are provided. Also provided are suites of small molecule entities as biomarkers for kidney cancer. | 11-20-2014 |
20140343866 | OCCLUSAL WEAR EVALUATION APPARATUS AND OCCLUSAL WEAR EVALUATION METHOD - An occlusal wear evaluation apparatus capable of evaluating quantitatively an occlusal wear of a used denture reads three dimensional data of a denture before use and three dimensional data of the denture after use. The apparatus calculates a difference in a set value of an articulator allowing the maxillary dental arch and the mandibular dental arch of the denture to occlude between the denture before use and the denture after use, by way of simulating movements of a jaw in the articulator with the three dimensional data of the denture before use and the three dimensional data of the denture after use, and indicates the calculated difference. | 11-20-2014 |
20140343867 | PORTABLE MONITORING DEVICES AND METHODS OF OPERATING SAME - The present inventions, in one aspect, are directed to a portable activity monitoring device comprising a housing having a physical size and shape that is adapted to couple to the user's body, a plurality of sensors (for example, motion sensor and altitude sensor) disposed in the housing. The monitoring device may further include processing circuitry, disposed in the housing and electrically coupled to the plurality of sensor, to calculate the activity points corresponding to the physical activity of the user using the sensor data, wherein the activity points correlate to an amount and intensity of the physical activity of the user, and output the data which is representative of the activity points. The monitoring device may also include a display, coupled to the processing circuitry, may output the data which is representative of the activity points to the user. | 11-20-2014 |
20140350862 | SENSOR ASSEMBLY FOR HYGENIC MATERIAL PROCESSING SYSTEMS - A sensor assembly includes a replaceable sensor module and an assembly housing. The assembly housing contains an assembly housing processor and an electrical connector connected to the processor. The replaceable sensor module has an enclosure adapted to be mounted in a position to sense a process variable, a process variable transducer positioned in said enclosure so as to be exposed to the process variable, and a non-volatile memory having stored therein specific profiling data for the sensor module. The assembly housing processor has data representing a desired sensor assembly output characteristic, and is responsive to receipt of specific profiling data and to the data representing the desired sensor assembly output characteristic to calibrate the sensor assembly to provide the desired sensor assembly output characteristic when connected to the sensor module having the specified profiling data. Radial and axial seals are provided for the openings in the assembly housing. Measurement of loop current (I | 11-27-2014 |
20140350863 | SYSTEMS AND METHODS FOR AUTOMATIC CREATION OF DOSE PREDICTION MODELS AND THERAPY TREATMENT PLANS AS A CLOUD SERVICE - The present invention proposes a method for automatically creating a dose prediction model based on existing clinical knowledge that is accumulated from multiple sources without collaborators establishing communication links between each other. According to embodiments of the claimed subject matter, clinics can collaborate in creating a dose prediction model by submitting their treatment plans into a remote computer system (such as a cloud-based system) which aggregates information from various collaborators and produces a model that captures clinical information from all submitted treatment plans. According to further embodiments, the method may contain a step where all patient data submitted by a clinic is made anonymous or the relevant parameters are extracted and condensed prior to submitting them over the communications link in order to comply with local regulations. | 11-27-2014 |
20140350864 | REAL-TIME MULTI-CHANNEL EEG SIGNAL PROCESSOR BASED ON ON-LINE RECURSIVE INDEPENDENT COMPONENT ANALYSIS - A real-time multi-channel EEG signal processor based on an on-line recursive independent component analysis is provided. A whitening unit generates covariance matrix by computing covariance according to a received sampling signal. A covariance matrix generates a whitening matrix by a computation of an inverse square root matrix calculation unit. An ORICA calculation unit computes the sampling signal and the whitening matrix to obtain a post-whitening sampling signal. The post-whitening sampling signal and an unmixing matrix implement an independent component analysis computation to obtain an independent component data. An ORICA training unit implements training of the unmixing matrix according to the independent component data to generate a new unmixing matrix. The ORICA calculation unit may use the new unmixing matrix to implement an independent component analysis computation. Hardware complexity and power consumption can be reduced by sharing registers and arithmetic calculation units. | 11-27-2014 |
20140350865 | CONTENT INFORMATION OUTPUT - A communication terminal obtains biological information. The communication terminal determines whether the obtained biological information satisfies preset conditions. When it is determined that the biological information satisfies preset conditions, the communication terminal creates content information indicating the contents of the output information. The communication terminal then provides the created content information to other communication terminals. | 11-27-2014 |
20140358446 | Selection of Genotyped Transfusion Donors by Cross-Matching to Genotyped Recipients - Disclosed are methods for establishing the compatibility between two blood types on the basis of cross-matching (under a designated rule of stringency) the minor blood group genotypes of recipient and prospective donors. To determine compatibility, the blood group genotypes are mapped to corresponding phenotypes according to the expression states associated with a set of underlying haplotypes, and compatibility is established by establishing the compatibility of blood types constructed as a combination of constituent phenotypes. The bit strings are matched, preferably using an algorithm expression. Where ambiguity in mapping genotypes to haplotypes exists, it can be reduced based on frequency of occurrence of the haplotypes in the sample population, or resolved by gametic phasing. Such reduction or resolution of ambiguity is particularly desirable where mismatches in the antigens expressed by the constituent haplotypes have greater clinical significance. | 12-04-2014 |
20140358447 | INSTANT, IN-SITU, NONDESTRUCTIVE MATERIAL DIFFERENTIATION APPARATUS AND METHOD - Specular, ultrasonic, piezoelectric, detection devices provide real-time, analytical, edge finding in tissues during tumor surgery. Piezoelectric probe sensors at high frequencies (e.g., 10 to 100 MHz) characterize microstructure of cells and tissues. Through-transmission or specular reflection enables nondestructive testing in real time. Peak density analysis in power spectra, second-order spectrum analysis measuring the slope of the Fourier transform of the power spectrum, artificial intelligence pattern recognition, and modeling interpret the results. Model-based data analysis may compare experimental data with a computer simulation. Such comparisons may be based upon pattern classifications, including principal component analysis (PCA). Combining the above detection devices and analytical methods provides speed, accuracy, simplicity, and nondestructive mechanisms that militate for reliable, real-time diagnosis of tumor margins, tissue pathology, cell phenotypes, and molecular subtypes. | 12-04-2014 |
20140358448 | COMPUTER READABLE MEDIUM FOR ENABLING A COMPUTER TO CARRY OUT PROVISION OF INFORMATION ON HEPATOCELLULAR CARCINOMA AND MARKER AND KIT FOR OBTAINING INFORMATION ON HEPATOCELLULAR CARCINOMA - The present invention is to provide a computer readable medium comprising a computer program for enabling a computer to carry out provision of information on hepatocellular carcinoma in a subject based on an analysis result on methylation status of a novel marker specific for hepatocellular carcinoma. | 12-04-2014 |
20140358449 | METHOD FOR IDENTIFYING MICROORGANISMS BY MASS SPECTROMETRY - A method of identifying a microorganism by mass spectrometry, including acquiring at least one mass spectrum of said microorganism; for each acquired mass spectrum: detecting peaks of the spectrum in a predetermined mass range; generating a list of peaks identifying at most one peak in each interval of a predetermined subdivision of the range of mass-to-charge ratios, the width of the intervals of the subdivision logarithmically increasing along with the mass-to-charge ratio, and analyzing the list(s) of peaks obtained according to a knowledge base of previously-identified microorganisms and/or types of microorganisms. | 12-04-2014 |
20140358450 | Method of Binding Site and Binding Energy Determination by Mixed Explicit Solvent Simulations - It is described a method of binding site and binding energy determination by mixed explicit solvent all-atoms molecular dynamics simulations. The macromolecular target for which high affinity binders are sought is simulated in several mixed solvent environments comprising water and at least one amphiphilic organic co-solvent. The simulations are run so that the mixture of solvents are free to react to the presence of the target without the addition of any forces other than those found in the original potential. A correction is applied that helps dissociating the distribution of the different chemical groups found in the amphiphilic organic solvents when calculating their free energies of binding. Additionally, a second correction can be applied accounting for the aggregation of said solvents. The correction helps determining more meaningful absolute, and more accurate relative free energies of binding that can be applied in the rational design of new binders to macromolecular targets. | 12-04-2014 |
20140365136 | Systems and Methods for Automatically Displaying Patterns in Biological Monitoring Data - Systems and methods for automatically displaying patterns in biological data may include one or more processors, and machine readable instructions. The machine readable instructions can cause the one or more processors to divide biological data into segments of interest. The one or more processers can transform, automatically, each of the segments of interest into a set of features according to a mathematical algorithm. Further, the one or more processers can cluster, automatically, the segments of interest into groups of clustered segments according to a clustering algorithm. The segments of interest can be grouped in the groups of clustered segments based at least in part upon the set of features. A cluster center can be associated with one of the groups of clustered segments. Moreover, the one or more processers can present, automatically, the cluster center on a human machine interface. | 12-11-2014 |
20140365137 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR QUANTIFYING FDG UPTAKE ON PET - The increasing use of molecular imaging probes as biomarkers in oncology can emphasize the need for robust and stable methods for quantifying tracer uptake on PET. A histogram-based system, method and computer-accessible procedure can be used to calculate a new tracer uptake metric and the background subtracted lesion activity. | 12-11-2014 |
20140365138 | SYSTEMS AND METHODS FOR PATTERN RECOGNITION IN DIABETES MANAGEMENT - A diabetes management system or process is provided herein that may be used to analyze and recognize patterns for a large number of blood glucose concentration measurements and other physiological parameters related to the glycemia of a patient. In particular, a method of monitoring glycemia in a patient may include storing a patient's data on a suitable device, such as, for example, a blood glucose meter. The patient's data may include blood glucose concentration measurements. The diabetes management system or process may be installed on, but is not limited to, a personal computer, an insulin pen, an insulin pump, or a glucose meter. The diabetes management system or process may identify a plurality of pattern types from the data including a testing/dosing pattern, a hypoglycemic pattern, a hyperglycemic pattern, a blood glucose variability pattern, and a comparative pattern. After identifying a particular pattern with the data management system or process, a warning message may be displayed on a screen of a personal computer or a glucose meter. Other messages can also be provided to ensure compliance of any prescribed diabetes regiments or to guide the patient in managing the patient's diabetes. | 12-11-2014 |
20140365139 | SYSTEM AND METHOD FOR ASSESSING A CONDITION OF A PATIENT WITH A CHRONIC ILLNESS - Provided are a method and system for assessing a condition of a patient with a chronic condition. The system includes a storage device that stores a plurality of variables relating to symptoms being experienced by the patient during an exacerbation of the chronic condition. A baseline component establishes a baseline indicative of a normal condition of the patient with the chronic condition while not experiencing an exacerbation. A risk assessment component is operable to compare the condition of the patient as determined based on the variables to the baseline to determine a severity of the exacerbation of the chronic condition relative to the baseline. | 12-11-2014 |
20140365140 | METHOD AND REFERENCE MODEL FOR CHECKING A MEASURING SYSTEM - The invention relates to a reference object ( | 12-11-2014 |
20140365141 | Systems and Methods for Genotyping by Angle Configuration Search - Methods and systems for the analysis of genotyping data are presented. According to various embodiments of methods and systems, an angle configuration search may be performed. In various embodiments, an exhaustive search over the entirety of an angle configuration space may be performed to provide a fit to a plurality of angles determined for a plurality of points in a data set generated from a plurality of biological samples. For various embodiments, the angle configuration space may be defined to ensure that a global fit may be determined. According to various methods and systems, a data base of possible angle configurations may be searched, in which each angle configuration may include three angles. According to various methods and systems, a data base of possible angle configurations may include for each angle configuration a probability that the angle configuration may occur. | 12-11-2014 |
20140372045 | Method and an apparatus for indirect measurement of fluid in a container and communication thereof - A fluid intake monitoring system comprises a sensor band and a mobile device. The sensor band is configured for selective attachment to a fluid container and includes a microprocessor, an accelerometer, and an RF transceiver. The accelerometer measures and outputs acceleration data indicative of the movement of the fluid container and the microprocessor processes the acceleration data and computes threshold values. The mobile device is configured to wirelessly communicate with the sensor band and has a mobile software application comprising modules for receiving data from the sensor band, computing and distinguishing drinking events and non-drinking events. True drinking events are stored and compared with a baserate of hydration for a particular user. Alerts are sent to the user for optimized level of hydration. | 12-18-2014 |
20140379267 | GASTRIC EMPTYING BREATH TESTS - A breath test and a breath test method for diagnosing abnormal gastric emptying using a | 12-25-2014 |
20140379268 | Method And Device For Preoperatively Predicting A Postoperative Horizontal Depth Of An Intraocular Lens In An Eye - The present application relates to a method and a device for preoperatively predicting a postoperative horizontal depth of an intraocular lens in a patient's eye. Parameter values are provided, said parameters including a first parameter as the depth of an anterior chamber of human eyes, a second parameter as a horizontal length of human eyes, and a third parameter as a postoperative position of intraocular lenses in human eyes. Specific triplets of values are selected from said values as main interpolation nodes, each triplet of values comprising a value for each of the three aforementioned parameters, and the main interpolation nodes are entered into a three-dimensional coordinate system that is spanned by the three parameters. The main interpolation nodes are connected by edge connecting lines, and a predictive network that is unevenly formed in the three-dimensional coordinate system is generated at least using the positions of the edge connecting lines in order to predict the postoperative horizontal depth of the intraocular lens in the patient's eye. | 12-25-2014 |
20140379269 | SYSTEMS, METHODS AND APPARATUS FOR DETERMINING A FRACTIONAL FLOW RESERVE - In one aspect, the invention relates to system comprising: a processor configured to receive a first optical coherence tomography (OCT) data set obtained during a pullback of a data collection probe along a first length of a first blood vessel; determine a minimum lumen area disposed along the first length using the first OCT data set; and determine a first FFR value along the first length based on the minimum lumen area. In one embodiment, the first FFR value is an estimated FFR. In another aspect, the invention relates to a method that includes measuring, using OCT, the area of a lumen of a vessel for which the vessel's FFR is to be determined; and calculating, using a computer, A | 12-25-2014 |
20140379270 | SYSTEM AND METHOD FOR ALIGNING GENOME SEQUENCE CONSIDERING MISMATCH - A system and method for aligning a genome sequence considering mismatches are provided. The system for aligning a genome sequence includes an error bound calculation unit configured to calculate an error bound of a read according to a length of the input read, a comparison unit configured to calculate an error number estimate of the read and compare the error bound with the calculated error number estimate, and an alignment unit configured to perform a global alignment of the input read with a reference sequence when the comparison result shows that the calculated error number estimate is less than or equal to the error bound. | 12-25-2014 |
20140379271 | SYSTEM AND METHOD FOR ALIGNING GENOME SEQUENCE - A system and method for aligning a genome sequence are provided. The system for aligning a genome sequence includes a seed generation unit configured to generate a plurality of seeds from an input read, a filtering unit configured to map the generated seeds to a reference sequence and select target seeds for global alignment from the mapped seeds in consideration of gaps between the mapped seeds, and an alignment unit configured to perform a global alignment of the read with the reference sequence in mapping positions in which the selected seeds are mapped to the reference sequence. | 12-25-2014 |
20140379272 | LIFE ANALYSIS SYSTEM AND PROCESS FOR PREDICTING AND FORECASTING LIFE EVENTS - A process for predicting and forecasting life events and a system that performs a life analysis of a person and predicts life events, milestones, and other life paths are disclosed. Predictability and intelligent forecasting of life statuses, milestones, and achievements are provided through a unique combination of algorithms, heuristic rules, data analytics and digitization. | 12-25-2014 |
20140379273 | System For Improved Interpretation of Physiological Data and Presentation of Physiological Condition Management Information - Systems, devices and methods for managing a physiological condition are configured to store predetermined output segments of content, analyze physiological data and other user information, and generate user-friendly information that provides an interpretation of the data (e.g., identifies selected data points, or determines pattern of physiological data over selected period(s)). An output segment management system with rules engine and method combines selected output segments to generate a presentation or message (e.g., with text, graphical, multimedia, video and/or audio information). The resulting presentation or message provides user information such as an explanation of selected data with selected user information incorporated therein, and optional recommendations (e.g., suggested user actions based on a designated protocol such as a clinical protocol). | 12-25-2014 |
20140379274 | BIOLOGICAL SAMPLE MEASUREMENT DEVICE - A biological sample measurement device comprising a main body case including a sensor mounting component; a measurement component including an input side; a controller connected to the measurement component, the controller including a measurement preparation mode and a measurement mode, the controller configured to determine whether there is an abnormality in the measurement component; a memory component connected to the controller; a switching component connected to the input side of the measurement component, a first reference resistor, and to the sensor mounting component; the switching component configured to switch between at least two states. | 12-25-2014 |
20140379275 | BIOMETRIC MONITORING DEVICE HAVING A BODY WEIGHT SENSOR, AND METHODS OF OPERATING SAME - A system comprising a biometric monitoring device including a housing including a platform to receive at least one foot of the user, a body weight sensor to generate body weight data, processing circuitry to calculate user weight data which corresponds to the user's weight, using the body weight data, and communication circuitry to: (a) receive user identification data which identifies the user or a portable activity monitoring device, and (b) transmit the user weight data to data storage associated with the user identification data. The system further includes the portable activity monitoring device including a housing having a physical size and shape that is adapted to couple to the user's body, a sensor to generate sensor data, and communication circuitry to receive physiologic data which is based on the user weight data, and processing circuitry to calculate activity data using the sensor data and physiologic data. | 12-25-2014 |
20150012222 | METHOD AND SYSTEM FOR ANALYZING NOISE IN AN ELECTROPHYSIOLOGY STUDY - A method for analyzing noise in an electronic signal monitoring study includes selecting a study signal for analysis, removing a study subject's physiological signal from the study signal, and performing a quantitative analysis on the study signal. A fingerprint of any noise present in the study signal is then created. | 01-08-2015 |
20150012223 | REMINDER, CLASSIFICATION, AND PATTERN IDENTIFICATION SYSTEMS AND METHODS FOR HANDHELD DIABETES MANAGEMENT DEVICES - A method includes: measuring a blood glucose (bG) level in a blood sample; storing the bG level and a time of receipt of the blood sample; storing a classification of the blood sample; in response to the receipt of the blood sample, selecting a group of stored bG levels having the classification of the blood sample and that were received within a predetermined period before receipt of the blood sample; calculating a bG evaluation parameter from the selected bG levels; evaluating the bG evaluation parameter in relation to first predetermined criteria, the first predetermined criteria including a first threshold indicative of a high bG level or a low bG level; selectively displaying an indication of recognition of a pattern in the selected bG levels when the bG evaluation parameter is greater than or less than the first threshold; and selectively removing the indication from the display. | 01-08-2015 |
20150012224 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING BODY-CONFORMING ANIMAL BED, CALIBRATION CELL AND ORGAN PROBABILITY MAP FOR QUANTITATIVE OPTICAL IMAGING OF ANATOMICAL STRUCTURES - Exemplary systems, methods and computer accessible mediums which can determine quantitative information of a tissue(s) can be provided, which can include receiving optical information regarding the tissue(s), and determining the quantitative information of the tissue(s), in real time and during the receipt of the optical information, using an atlas. The tissue(s) can be part of a mouse, and the quantitative information can be an in-vivo count of cells or bacteria in the tissue(s). The quantitative information can be determined by co-registering the in-vivo count to the atlas. The optical information can be generated using a mirror gantry(s) so as to simultaneously image at least two opposing views of the tissue(s). | 01-08-2015 |
20150012225 | INFERRING A STATE OF A SYSTEM OVER TIME - The present disclosure relates to a method, apparatus, system and computer program for inferring a system state over time. Biomedical measurement data is obtained, wherein the data relate to at least one indicator of a system of interest and includes at least two indicator values being indicative of the state of the system of interest and the indicator values are measured at different time points. At least one measure of goodness for the indicator is formed by using values of the indicator of at least one control state and at least one comparison state. Difference values are formed for at least two indicator values with reference to the control and comparison states, and using the at least two difference values a change in value of said indicator is displayed with a progress indicator so that the change over time can be used in inferring the system state. The progress indicator has at least one dimension depending on the value of the at least one measure of goodness. | 01-08-2015 |
20150019135 | MOTION SENSOR AND ANALYSIS - The performance of an individual is monitored based on measurements of a conformal sensor device. An example system includes a communication module to receive data indicative of a measurement of at least one sensor component of the conformal sensor device. The sensor component obtains measurement of acceleration data representative of an acceleration proximate to the portion of the individual. A comparison of a parameter computed based on the sensor component measurement to a preset performance threshold value provides an indication of the performance of the individual. | 01-15-2015 |
20150019136 | SYSTEMS AND METHODS FOR DETERMINING RETINAL GANGLION CELL POPULATIONS AND ASSOCIATED TREATMENTS - A new combined index of structure and function (CSFI) for staging and detecting glaucomatous damage is provided. An observational study including 333 glaucomatous eyes (295 with perimetric glaucoma and 38 with preperimetric glaucoma) and 330 eyes of healthy subjects is described. All eyes were tested with standard automated perimetry (SAP) and spectral domain optical coherence tomography (SDOCT) within 6 months. Estimates of the number of retinal ganglion cells (RGC) were obtained from SAP and SDOCT and a weighted averaging scheme was used to obtain a final estimate of the number of RGCs for each eye. The CSFI was calculated as the percent loss of RGCs obtained by subtracting estimated from expected RGC numbers. The performance of the CSFI for discriminating glaucoma from normal eyes and the different stages of disease was evaluated by receiver operating characteristic (ROC) curves. The mean CSFI, representing the mean estimated percent loss of RGCs, was 41% and 17% in the perimetric and pre-perimetric groups, respectively (P<0.001). They were both significantly higher than the mean CSFI in the normal group (P01-15-2015 | |
20150019137 | Bioinformation Processing Apparatus and Signal Processing Method - Disclosed is a biological information processing apparatus and a signal processing method, wherein a biological signal comprising a first signal component having periodicity is generated, and a given frequency distribution is generated based on a second-order difference signal obtained by subjecting the biological signal to a second-order differencing operation, whereafter, with respect to the generated frequency distribution, an effective greatest frequency zone which is a zone having a greatest frequency of an interval-time is determined based on a given criterion, and a period of the first signal component is calculated based on an average time interval in the effective greatest frequency zone. | 01-15-2015 |
20150019138 | SYSTEMS AND METHODS FOR DETERMINING INGREDIENT AMOUNTS FOR PREPARATIONS FOR ADMINISTRATION TO PATIENTS - Computer systems and non-transitory computer readable media for determining an amount of an ingredient for a preparation for a requested therapy (e.g., an order or a prescription) includes an identifier, volume, and amounts of first and second compounds in each of a plurality of premix solutions. A predefined formulary comprising a formulary concentration of each of a plurality of additions is provided. A premix solution is selected. An amount of a first additions to be added to the premix solution may be selected. A number of bags of the premix solution, needed to satisfy a volume associated with the selected premix solution, are optionally reserved. An additive volume is determined at least by the specified first amounts of the first addition and a corresponding formulary concentration. | 01-15-2015 |
20150019139 | METABOLIC MONITORING, A METHOD AND APPARATUS FOR INDICATING A HEALTH-RELATED CONDITION OF A SUBJECT - An apparatus for indicating a health-related condition of a subject has an input interface for receiving a sequence of samples of a first biological quantity derived by a first measurement method, the first measurement method being an invasive measurement and having a first impact on the subject, and for receiving a sequence of samples of a second biological quantity derived by a second measurement method, the second measurement method being a non-invasive measurement and having a second impact on the subject, wherein the first biological quantity gives a more accurate indication of the health-related condition of the subject than the second biological quantity, wherein the first biological quantity and the second biological quantity have a correlation to the health-related condition of the subject, and wherein the second impact is smaller than the first impact; a predictor for providing, for a certain time, for which no sample for the first biological quantity exists, an estimated value of the first biological quantity using samples for the first biological quantity and, as far as available, samples for the second quantity; and an output interface for outputting the estimated value or data derived from the estimated value so that an indication for the health-related condition of the subject is obtained. | 01-15-2015 |
20150025808 | Methods and Systems for Processing Test Results Based on Patient-Specific Data and Reference Data - Methods and systems for processing test results based on patient-specific data and reference data are provided. An example method includes processing a result of a diagnostic test performed on a patient based on reference data that is based on testing of a group of patients. The method also includes processing the result based on patient-specific data that includes previous test results of the diagnostic test previously performed on the patient, and providing an indication indicative of an abnormal test result based on the result being in a normal range of the reference data and having a variance from the patient-specific data of a threshold amount. In another example, a method includes providing an indication indicative of a normal test result based on the result being outside a normal range of the reference data and being between an upper limit and a lower limit of the patient-specific data. | 01-22-2015 |
20150025809 | Method of Regulating Caloric Intake - A method, including: determining steady state values for daily caloric parameters that conform a person to weight management goal, the daily caloric parameters including a daily base metabolic rate (BMR) and a target offset from a daily total daily energy expenditure (TDEE), wherein the TDEE includes the BMR; determining an intake shortfall for a plurality of days between actual daily offsets and the steady state target offset; making a recommendation including food to be consumed to reduce the shortfall, the recommendation effective to account for a transient change in a hunger response resulting from the consumption of the recommended food; causing consumption on an up adjustment day; and determining transient values for at least one of the daily caloric parameters to be used subsequent to the consumption on the up-adjustment day effective to bring an average of the actual daily offsets closer to the steady state target offset. | 01-22-2015 |
20150025810 | ASSAY TO DETECT A GYNECOLOGICAL CONDITION - The present invention relates generally to the field of diagnostic and prognostic assays for a gynecological condition. More particularly, the present invention provides an assay for diagnosing the presence of or a risk of having a gynecological cancer or a sub-type thereof or a stage of the cancer or complications arising therefrom or other gynecological condition including an inflammatory disorder. | 01-22-2015 |
20150025811 | APPARATUS FOR PREDICTING CHANGE IN PHYSICAL INDEX - An apparatus | 01-22-2015 |
20150025812 | METHOD AND APPARATUS FOR DISCOVERY, DEVELOPMENT AND CLINICAL APPLICATION OF MULTIPLEX ASSAYS BASED ON PATTERNS OF CELLULAR RESPONSE - A method for the discovery, development and clinical application of multidimensional multiplex synthetic biomarker assays based on patterns of cellular response. | 01-22-2015 |
20150032381 | Allelotyping Methods for Massively Parallel Sequencing - In one illustrative embodiment, an allelotyping method may include selecting a plurality of text strings that each represent a nucleotide sequence that was read by a massively parallel sequencing (MPS) instrument, where the nucleotide sequences represented by the selected plurality of text strings each correspond to a particular locus, comparing the selected plurality of text strings to one another to determine an abundance count for each unique text string included in the selected plurality of text strings, and determining one or more alleles for the particular locus by comparing the abundance count for each unique text string included in the selected plurality of text strings to an abundance threshold. | 01-29-2015 |
20150032382 | APPARATUS AND METHOD FOR DETERMINING DROWSY STATE - An apparatus and a method for determining a drowsy state include an information acquirer acquiring physiological information of a user, a mode determiner setting an operation mode among modes categorized according to variable applied to determine a drowsy state of the user. A threshold determiner sets a threshold for an application variable of the set mode based on data in a reference table stored in database (DB). A physiological index calculator calculates a measurement value for each of the application variables based on state information of the user acquired in real time from the information acquirer. A state determiner determines the drowsy state of the user by comparing a user table generated from the measurement value calculated for each of the application variables with the reference table. | 01-29-2015 |
20150032383 | METHOD AND SYSTEM FOR FILTERING GAS CHROMATOGRAPHY-MASS SPECTROMETRY DATA - This invention relates to a system for and a method of filtering at least a part of gas chromatography-mass spectrometry data, the method comprising: providing gas chromatography-mass spectrometry data ( | 01-29-2015 |
20150032384 | APPARATUS FOR SUPPORTING AND MONITORING A PERSON - A person-support structure includes a control system, an input configured to communicate a first input signal to the control system, and a sensor configured to sense a physiological characteristic of a person supported on the person-support structure. The sensor communicates a second input signal corresponding to the physiological characteristic to the control system. The control system calculates a condition score as a function of the first input signal and the physiological characteristic of the person and compares the condition score to a predetermined threshold. The control system scales at least one of the physiological characteristic of the person and the predetermined threshold as a function of the first input signal. | 01-29-2015 |
20150039237 | INDEXING GENE EXPRESSION DATA TO COMPARE GENE SIGNATURES - Indexing gene expression data for comparing gene signatures includes assigning one of a plurality of fold change-based grading scores to each of a number of genes in a probe gene signature. The fold change-based grading scores reflect relative expression of one of the number of genes in the probe gene signature. Each of the number of genes in the probe gene signature assigned a particular grading score is weighted by the particular grading score. A ratio of each weighted number of genes in the probe gene signature assigned a particular grading score to a total number of genes in the probe gene signature is determined. Then, ratios of each weighted number of genes in the probe gene signature assigned each particular grading score to the total number of genes in the probe gene signature are summed to generate an index of gene expression. | 02-05-2015 |
20150039238 | Dispersion-Relation Fluorescence Spectroscopy - Methods for deriving a diffusion coefficient and a drift velocity characterizing an ensemble of particles. A time series of images is acquired, and each image is Fourier transformed. An autocorrelation function is computed and fit to an exponential decay for each wave vector on a grid. A model of the diffusion-advection equation allows the decay rate Γ, expressed as a dispersion map over the wave vector plane, to yield both a diffusion coefficient and a mean drift velocity. As an example, the particles may be fluorescently excited probes where the probes label intracellular elements. | 02-05-2015 |
20150039239 | PROCESSOR-BASED METHODS, SYSTEMS AND PROGRAMS FOR REMOTE ANIMAL HEALTH MONITORING, ASSESSMENT, DIAGNOSIS, AND MANAGEMENT - Processor-based methods and systems and computer programs for remote animal health monitoring receive and process data relating to animal health parameters obtained from a plurality of different types of sensors. Baseline data signatures are determined from the data obtained for individual animals, and as data is subsequently collected is compared to the current data signature to assess animal health. Deviations from the signatures may serve to predictively diagnose certain conditions and facilitate medical intervention before adverse physical symptoms are manifested. Informational data and analytics are made available to animal owners, health care providers, and other interested persons. | 02-05-2015 |
20150039240 | PROTEIN IDENTIFICATION METHOD AND SYSTEM - When a terminal sequence to be investigated is specified (S | 02-05-2015 |
20150046094 | SURGICAL GUIDANCE AND PLANNING SOFTWARE FOR ASTIGMATISM TREATMENT - Software for calculating an astigmatism treatment is operable upon execution to perform the following steps: receiving an initial primary incision position; determining a power and orientation for a toric intraocular lens (IOL) to treat an astigmatism of an eye based on the initial primary incision position; determining an adjusted primary incision position based on the power and the orientation for the toric IOL to further reduce the astigmatism; and generating an output comprising the adjusted primary incision position. | 02-12-2015 |
20150046095 | PULSE MONITOR AND PROGRAM - A pulse monitor, a program, and the like which perform determination of an appropriate pressing force and store and display holding state specification information when it is determined to be an appropriate pressing force, thereby facilitating device mounting in an appropriate state are provided. A pulse monitor includes a pulse wave detection unit | 02-12-2015 |
20150051839 | METHOD FOR CHARACTERISING PLASMA CELL ASSOCIATED DISEASES - The invention provides a method for characterising a plasma cell associated disease in a patient comprising: (i) providing at least one sample from the patient; (ii) determining in the sample(s) two or more of; (a) the κ:λ free light chain (FLC) ratio; (b) the ratio of κ light chains bound to a class of heavy chain:λ light chain bound to the same class of heavy chain (HLCκ:HLC λ ratio); (c) the total amount of FLC in the samples and (d) the total amount of κ light chains bound to the heavy chain class plus λ light chains bound to the same heavy chain class (total HLC); (iii) comparing each ratio or amount from (a) (b), (c) and/or (d) to predetermined values and assigning a score to each amount or ratio; and (iv) using the scores to characterise the plasma cell associated disease. Apparatus configured to carry out the method of the invention are also provided. The invention also provides a kit comprising, in combination, (i) anti-κ FLC specific and anti-λ FLC specific antibodies or fragments thereof and (ii) anti-κ heavy chain class specific and anti-λ heavy chain class specific antibodies or fragments thereof, optionally mixed together. | 02-19-2015 |
20150051840 | Identification Of Microorganisms By Spectrometry And Structured Classification - A method of identifying by spectrometry of unknown microorganisms from among a set of reference species, including a first step of supervised learning of a classification model of the reference species, a second step of predicting an unknown microorganism to be identified, including acquiring a spectrum of the unknown microorganism; and applying a prediction model according to said spectrum and to the classification model to infer at least one type of microorganism to which the unknown microorganism belong. The classification model is calculated by a structured multi-class SVM algorithm applied to the nodes of a tree-like hierarchical representation of the reference species in terms of evolution and/or of clinical phenotype and having margin constraints including so-called “loss” functions quantifying a proximity between the tree nodes. | 02-19-2015 |
20150057939 | MODIFYING A COSMETIC PRODUCT BASED ON A MICROBE PROFILE - Systems and methods are described for modifying a cosmetic product based on a microbe profile including an ingredient-microbe interaction dataset including information associated with interactions between reference cosmetic ingredients and types of reference microbes; and a computing device including circuitry configured to receive information associated with the microbe profile of an individual, receive information associated with an ingredient list of the cosmetic product, compare the microbe profile of the individual and the ingredient list of the cosmetic product to the ingredient-microbe interaction dataset, identify an interaction between at least one cosmetic ingredient in the ingredient list of the cosmetic product and at least one of the one or more types of microbes in the microbe profile of the individual, recommend a modification to the ingredient list in response to an identified interaction, and report to a user the recommended modification. | 02-26-2015 |
20150057940 | MODIFYING A COSMETIC PRODUCT BASED ON A MICROBE PROFILE - Systems and methods are described for modifying a cosmetic product based on a microbe profile including an ingredient-microbe interaction dataset including information associated with interactions between reference cosmetic ingredients and types of reference microbes; and a computing device including circuitry configured to receive information associated with the microbe profile of an individual, receive information associated with an ingredient list of the cosmetic product, compare the microbe profile of the individual and the ingredient list of the cosmetic product to the ingredient-microbe interaction dataset, identify an interaction between at least one cosmetic ingredient in the ingredient list of the cosmetic product and at least one of the one or more types of microbes in the microbe profile of the individual, recommend a modification to the ingredient list in response to an identified interaction, and report to a user the recommended modification. | 02-26-2015 |
20150057941 | METHOD FOR COMPUTING A PARAMETER REPRESENTATIVE OF THE ENDURANCE OF A TENNIS PLAYER - Method for calculating a parameter representing a tennis player's endurance during a game period including a series of game sessions, includes: a) measuring the linear acceleration and angular speed of the racket during each stroke hit by the player, b) calculating the power developed by the player during each stroke using linear accelerations and angular speeds measured in step a); c) calculating the player's average power defined as the average of power levels developed during each stroke calculated in step b); d) calculating the energy expended by the player during the last game session, the energy expended being equal to the number of strokes executed during the session multiplied by the average power calculated in step c) raised to a predetermined power, e) calculating the parameter, defined by the product of the number of game sessions per week during the game period, multiplied by the energy calculated in step d). | 02-26-2015 |
20150057942 | Energy Expenditure Device - Athletic activity may be tracked and monitored while providing encouragement and maintaining an individual's interest in continuing to perform athletic activity. For example, energy expenditure values and energy expenditure intensity values may be calculated based on the duration and type of activity performed by an individual. These values and other movement data may be displayed on an interface in a manner to motivate the individual and maintain the individual's interest. Other individuals (e.g., friends) may also be displayed on an interface through which a user's progress is tracked. This may allow the user to also view the other individuals' progress toward completing an activity goal and/or challenge. | 02-26-2015 |
20150057943 | Energy Expenditure Device - Athletic activity may be tracked and monitored while providing encouragement and maintaining an individual's interest in continuing to perform athletic activity. For example, energy expenditure values and energy expenditure intensity values may be calculated based on the duration and type of activity performed by an individual. These values and other movement data may be displayed on an interface in a manner to motivate the individual and maintain the individual's interest. Other individuals (e.g., friends) may also be displayed on an interface through which a user's progress is tracked. This may allow the user to also view the other individuals' progress toward completing an activity goal and/or challenge. | 02-26-2015 |
20150057944 | SESSIONS AND GROUPS - Athletic activity may be tracked while providing encouragement to perform athletic activity. For example, energy expenditure values and energy expenditure intensity values may be calculated and associated with a duration and type of activity performed by an individual. These values and other movement data may be displayed on an interface in a manner to motivate the individual and maintain the individual's interest. The interface may track one or more discrete “sessions”. The sessions may be associated with energy expenditure values during a duration that is within a second duration, such as a day, that is also tracked with respect to variables, such as energy expenditure. Other individuals (e.g., friends) may also be displayed on an interface through which a user's progress is tracked. This may allow the user to also view the other individuals' progress toward completing an activity goal and/or challenge. | 02-26-2015 |
20150057945 | SESSIONS AND GROUPS - Athletic activity may be tracked while providing encouragement to perform athletic activity. For example, energy expenditure values and energy expenditure intensity values may be calculated and associated with a duration and type of activity performed by an individual. These values and other movement data may be displayed on an interface in a manner to motivate the individual and maintain the individual's interest. The interface may track one or more discrete “sessions”. The sessions may be associated with energy expenditure values during a duration that is within a second duration, such as a day, that is also tracked with respect to variables, such as energy expenditure. Other individuals (e.g., friends) may also be displayed on an interface through which a user's progress is tracked. This may allow the user to also view the other individuals' progress toward completing an activity goal and/or challenge. | 02-26-2015 |
20150066376 | NON-INVASIVE PRENATAL TESTING METHOD BASED ON WHOLE-GENOME TENDENCY SCORING - Provided is a non-invasive prenatal testing method based on whole-genome tendency scoring and adapted to test whether a pregnant woman's fetus has autosomal aneuploidy. The method includes: creating a database of m | 03-05-2015 |
20150066377 | Method for Classification of a Sample on the Basis of Spectral Data, Method for Creating a Database and Method for Using this Database, and Corresponding Computer Program, Data Storage Medium and System - The invention relates to a method for classification of a sample on the basis of spectral data, a method for creating a database and a method for using this database, and corresponding computer program, data storage medium and system. The method comprises: a) obtaining at least two sets of first spectra for use as reference spectra, each set comprising spectra of reference samples belonging to the same class; b) determining for each of the reference spectra the value of the same at least one quantity related to a spectral feature; c) associating a probability to different values of the quantity on the basis of the determined values; d) obtaining a spectrum from the sample and determining the value of the same at least one quantity of this spectrum; and e) calculating on the basis of the probabilities and the value of the quantity for the obtained spectrum for each of said at least two classes a probability that the sample belongs to that class. | 03-05-2015 |
20150066378 | Identifying Possible Disease-Causing Genetic Variants by Machine Learning Classification - The techniques described herein relate identification of disease-causing genetic variant by machine learning classification. The techniques may include receiving a training dataset of predetermined variants associated with disease. A hyperplane is identified having a maximum margin between points of the dataset. Patient input data is received including an observed variant of a gene. Features of the observed variant are selected, and a score is determined The score is determined using Support Vector Machine algorithms based on an observation of a novel non-linear relationship with the selected features of the observed variant. The observed variant may be classified based on the score indicating a distance of the observed variant from the identified hyperplane. | 03-05-2015 |
20150066379 | COMPUTER SYSTEM AND APPARATUS FOR DETERMINING SENSITIVITY TO BREAST CANCER NEOADJUVANT CHEMOTHERAPY - Sensitivity to breast cancer neoadjuvant chemotherapy is determined on the basis of a result of analysis of the expression level, by amplifying RNA extracted from a specimen collected from a subject, thereby preparing a measurement sample, and measuring an expression level of each specified gene with a use of using the measurement sample. | 03-05-2015 |
20150066380 | MASS SPECTROMETORIC DATA ANALYZING APPARATUS AND ANALYZING METHOD - A tag database establishment section converts, based on information such as an amino acid sequence of an identified peptide and m/z of a peak, a sequence tag indicating a partial sequence and information related to the tag into a database and creates a tag database. When MS2 spectrum information is obtained by measuring a target peptide, a sequence tag acquisition section executes, on the tag database, a search based on coincidence of the m/z of the peak and the like and extracts a sequence tag with high reliability. A peptide identification section performs, based on an amino acid sequence of the sequence tag, m/z of a precursor ion, and the like, a search by a sequence tag search method taking into account a post-translational modification or a variation and identifies a peptide. | 03-05-2015 |
20150066381 | GENOMIC PIPELINE EDITOR WITH TOOL LOCALIZATION - The invention provides systems and methods for creating and using genomic analysis pipelines in which each analytical step within the pipeline can be independently set to run in a particular location. Steps that involve patient-identifying information or other sensitive research results can be restricted to running on a computer that is under the user's control, while steps that require a vast amount of processing power to sift through large amounts of raw data can be set to run on a powerful computer system such as a multi-processor server or cloud computer. The system provides a genomic pipeline editor with a plurality of genomic tools that can be arranging into pipelines. For one or more of the tools, the system receives a selection indicating execution by a particular computer. The system will cause genomic data to be analyzed according to the pipeline and the location selection. | 03-05-2015 |
20150066382 | METHOD AND ANALYSIS SYSTEM FOR PROCESSING BIOLOGICAL SAMPLES - A method for guiding user input on a computer system of an analysis system that includes an in vitro diagnostic, IVD, device. The IVD device is coupled to the computer system that includes a display, processor, and memory to store applications being executable on the processor. A first application includes instructions that generate on the display a first graphical user interface that includes a set of user interface elements. Each user interface element is positioned in a defined region within the first graphical user interface. The first application includes instructions that control the IVD device to perform an IVD task that includes a sequence of IVD actions. The user activation of the IVD action is performed using a corresponding user interface element. The memory includes geometry data describing a display position for each interface element. | 03-05-2015 |
20150073716 | CROP LOSS DETERMINATION - In one example, a method includes receiving, by a crop loss determination generator (CLDG) executing on a computing device, data for a region of interest that includes growing crops. The data for the region of interest includes at least one of field data, crop data, and geographic data. The method further includes determining, by the CLDG and based on the received data for the region of interest, that a crop loss status of the growing crops within the region of interest reflects nonconformance with acceptable crop loss criteria. The crop loss status includes an indication of at least one of an extent and a scope of crop loss of the growing crops within the region of interest. The method further includes outputting, by the CLDG and in response to determining that the crop loss status reflects nonconformance with the acceptable crop loss criteria, at least one alert. | 03-12-2015 |
20150073717 | MONITORING BIOMETRIC CHARACTERISTICS OF A USER OF A USER MONITORING APPARATUS - Apparatuses, methods and systems for a user monitoring apparatus are disclosed. One embodiment of the user monitoring apparatus includes one or more magnetic sensors operative to sense magnetic fields applied to the user monitoring apparatus. Further, the user monitoring apparatus is operative to sense at least one biometric characteristic of a user of the user monitoring apparatus based upon the sensed magnetic field applied to the user monitoring apparatus. | 03-12-2015 |
20150073718 | PHASE-DIFFERENCE DETERMINATION USING TEST METER - A hand-held test meter includes a strip port connector to receive a test strip. A signal-measurement circuit applies a periodic voltage signal across a sample applied to the strip and detects a resulting current signal. The circuit provides data of the current signal at a digitizing frequency and a selected phase with respect to the voltage signal. A processor records one or more value(s) of the data and then alters the selected phase. Value(s) are thus recorded at each of a plurality of phases. The processor determines a phase difference of the current signal with respect to the voltage signal using the respective sets of value(s). A method for employing a test meter and a test strip is also disclosed, and includes measuring a respective plurality of points for each of a plurality of different measurement phases and determining a phase difference of a fluid sample therefrom. | 03-12-2015 |
20150073719 | COMPUTER-BASED SYSTEMS AND METHODS FOR ANALYZING GENOMES BASED ON DISCRETE DATA STRUCTURES CORRESPONDING TO GENETIC VARIANTS THEREIN - A computer-based method for analyzing genetic variants within a plurality of genomes includes submitting a query term to a database storing a plurality of discrete data structures within a memory. Each data structure can uniquely correspond to only one of the genetic variants present within the plurality of genomes, and can include a first data field comprising a unique alphanumeric identifier for the corresponding genetic variant and a second data field comprising a unique alphanumeric identifier for a genome in which the corresponding genetic variant is present. The query term can include a unique alphanumeric identifier for at least one genome and an operation to be performed. The method further can include searching the second data fields of the plurality of data structures stored in the database for matches to the query term that satisfy the operation; and generating an output representing the search result. | 03-12-2015 |
20150073720 | Device and Method for Automatically Normalizing the Physiological Signals of a Living Being - An example device includes: a data input module configured to receive information about a living being's physiological signals, coordinates, and motion intensity; an activity recognition module configured to calculate, from information received about the living being's motion intensity, a living being's activity; a location recognition module, configured to calculate, from information received about the living being's coordinates, a living being's location; a memory storage configured to store information about the living being's physiological signals and activity in association with the location; a normalization parameters estimator module configured to use a mathematical model to calculate a plurality of normalization parameters for a plurality of detected activities and locations; and a model selector module configured to determine, based on the plurality of normalization parameters and the living being's location, a set of location-specific normalization parameters used to further calculate normalized physiological signals for the living being. | 03-12-2015 |
20150073721 | SYSTEM AND METHOD TO SELECT SIGNAL SEGMENTS FOR ANALYSIS OF A BIOLOGICAL RHYTHM DISORDER - A system and method to process segments of cardiac signals. Each of a plurality of segments in a first signal is correlated at a plurality of offsets to determine a highest correlation coefficient for each of the plurality of segments in the first signal. Each of a plurality of segments in a second signal is correlated at the plurality of offsets to determine a highest correlation coefficient for each of the plurality of segments in the second signal. A plurality of composite correlation coefficients is generated using highest correlation coefficients for segments of the first signal and segments of the second signal. The segments of the first and second signals are approximately contemporaneous. A set of segments including a segment from the first signal and a segment from the second signal is selected. The set is associated with a highest composite correlation coefficient from the plurality of composite correlation coefficients. | 03-12-2015 |
20150073722 | METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW - Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. | 03-12-2015 |
20150073723 | Noninvasive Hydration Monitoring - Novel tools and techniques for assessing, predicting and/or estimating effectiveness of hydration of a patient and/or an amount of fluid needed for effective hydration of the patient, in some cases, noninvasively. | 03-12-2015 |
20150081224 | PREDICTING RISK OF MAJOR ADVERSE CARDIAC EVENTS - Measurement of circulating ST2 and natriuretic peptide (e.g., NT-proBNP) concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, transplantation, and heart failure. | 03-19-2015 |
20150081225 | Method and System for the Visualization of Brain Activity - At least one embodiment is directed to a fusion of sensors that generate a data set, where the data set identifies a visual image, where the data set is transmitted to a remote display where the visual image is displayed for a user. | 03-19-2015 |
20150081226 | MANAGING ELECTROENCEPHALOGRAM ANALYSIS - Systems and techniques for managing EEG analysis are described herein. EEG data, including an EEG scan of a patient, can be received from a site. The EEG data can be provided to an EEG interpreter. A normalized EEG interpretation for the EEG data can be received from an EEG interpreter. The normalized EEG interpretation can be delivered to the site. | 03-19-2015 |
20150088429 | METHODS AND SYSTEMS FOR PRE-CONCEPTUAL PREDICTION OF PROGENY ATTRIBUTES - Methods and systems for assessing the probabilities of the expression of one or more traits in progeny are described. | 03-26-2015 |
20150088430 | METHODS FOR EVALUATING LUNG CANCER STATUS - The invention in some aspects provides methods of determining the likelihood that a subject has lung cancer based on the expression of informative-genes. In other aspects, the invention provides methods for determining an appropriate diagnostic intervention plan for a subject based on the expression of informative-genes. Related compositions and kits are provided in other aspects of the invention. | 03-26-2015 |
20150088431 | DYNAMIC PROFILES - Implementations disclosed herein provide a monitoring technology. In one implementation, a monitoring system measures whole body biometric levels by analysis of changes in vascular volume caused by pulsatile pressure waves and in tissue volume in response to the pulsatile pressure. The monitoring system includes a monitoring device, which uses a light-based measurement technique to measure biometric levels during different activities and at rest. A light source operatively connected to a light sensor, transmits light, reflectively or transmissively, through tissue. The light sensor detects absorption of the light. Based on wavelength measurements of the detected light, the monitoring device produces a PPG waveform representing characteristic effects of certain physiological parameters. In one implementation, operating contexts are sensed in a monitoring device. A monitoring profile is selected based on the sensed operating contexts. A biometric is computed based on the PPG waveform and on the selected monitoring profile. | 03-26-2015 |
20150094961 | PHASING AND LINKING PROCESSES TO IDENTIFY VARIATIONS IN A GENOME - Long fragment read techniques can be used to identify deletions and resolve base calls by utilizing shared labels (e.g., shared aliquots) of a read with any reads corresponding to heterozygous loci (hets) of a haplotype. For example, the linking of a locus to a haplotype of multiple hets can increase the reads available at the locus for determining a base call for a particular haplotype. For a hemizygous deletion, a region can be linked to one or more hets, and the labels for a particular haplotype can be used to identify which reads in the region correspond to which haplotype. In this manner, since the reads for a particular haplotype can be identified, a hemizygous deletion can be determined. Further, a phasing rate of pulses can be used to identify large deletions. A deletion can be identified with the phasing rate is sufficiently low, and other criteria can be used. | 04-02-2015 |
20150094962 | OBSTRUCTIVE SLEEP APNEA TREATMENT SCREENING METHODS - Embodiments include a screening method for evaluating patient suitability for an implanted hypoglossal nerve stimulation (HGNS) device. The screening method evaluates blood oxygen data relating to respiratory events, with the blood oxygen data providing mean blood oxygen desaturation values for comparison to severity thresholds to identify patients who are likely or unlikely to benefit from the implantation of the HGNS device. | 04-02-2015 |
20150100242 | METHOD, KIT AND ARRAY FOR BIOMARKER VALIDATION AND CLINICAL USE - The methods provided focus on a quantitative molecular assay tools that systematically measure a set of pre-selected targets, with proper controls in a biological sample for identification of biomarkers or novel targets for a disease status. This allows for systematically maximizing the power of multivariate feature selection tools on the analysis of high-throughput screening data (such as microarray) and use of the well selected target to generate a qPCR array with tissue specific controls and qPCR controls to serve the needs of biomarker study. | 04-09-2015 |
20150100243 | Method and System for Displaying Genetic and Genealogical Data - A method and system for displaying genetic and genealogical data includes displaying indicators of related individuals. At least one genetically related individual is identified from a genetic database in response to a genetic input of an inquiring individual. Indicators of the inquiring individual and each of the at least one genetically related individual are displayed. The system includes a computer system having a display device, a processor device, a database and media having computer-executable instructions configured to display indicators of related individuals according to a method. The method includes identifying at least one genetically related individual from a genetic database in response to a genetic input of an inquiring individual and geographically displaying indicators of the inquiring individual and each of the at least one genetically related individual. | 04-09-2015 |
20150100244 | METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS - Provided herein are methods, processes, systems and machines for non-invasive assessment of genetic variations. | 04-09-2015 |
20150100245 | SYSTEMS, METHODS, APPLICATIONS FOR SMART SENSING, MOTION ACTIVITY MONITORING, AND MOTION ACTIVITY PATTERN RECOGNITION - A computer-implemented method for recognizing a user's activity pattern includes pre-storing activity data in a computer system, automatically determining locations of one or more sensors on a user's body, obtaining time series of measured activity parameters by the one or more sensors, automatically segmenting the time series of measured activity parameters into two or more activity periods, determining a spatial range of the movement in an activity period, and recognizing an activity in the activity period based at least in part on the measured activity parameters and the pre-stored activity data. | 04-09-2015 |
20150100246 | SYSTEM AND METHOD FOR PREDICTING COLON CANCER RECURRENCE - Systems and methods are provided that can predict a likelihood of post-resection colon cancer recurrence. The systems and methods can be implemented by a computing device that includes a non-transitory computer readable storage medium storing machine executable instructions and a processor that executes the machine executable instructions. Upon execution of the machine executable instructions, a feature extractor can be configured to determine a morphological feature from an image of resected tumor tissue. Upon execution of the machine executable instructions, a scorer can be configured to determine a risk score that indicates the likelihood of post-resection colon cancer recurrence based on the morphological feature. The risk score can be displayed on a user interface in a human comprehensible form. | 04-09-2015 |
20150106020 | Method and Apparatus for Wireless Health Monitoring and Emergent Condition Prediction - The present invention relates generally to wireless, remote, physiological monitoring in the evaluation of health and disease state specifically with respect to cardiac and pulmonary pathologies, including heart failure and sleep apnea. Personalized thresholds are used to enhance performance of classification and prediction methods by utilizing patient clinical history and past empiric sensed data, such as through an initialization period, to learn the biological variation present in each sensed individual. | 04-16-2015 |
20150106021 | INTERACTIVE VISUAL ANALYSIS OF CLINICAL EPISODES - Methods, systems, and articles of manufacture for exemplary visual analytics are provided herein. Visual analytics techniques are provided that combine pattern mining and temporal event visualization-based techniques. Visual episode query tools allow interactive specification of episode definitions and are combined with on-demand data analytics that perform pattern mining to help discover important intermediate events within an episode, and dynamic information visualization that allow interactive exploration and analysis of clinical event sequence data. The disclosed interactive visualization techniques identify events that impact outcome and how those associations change over time. | 04-16-2015 |
20150106022 | INTERACTIVE VISUAL ANALYSIS OF CLINICAL EPISODES - Methods, systems, and articles of manufacture for exemplary visual analytics are provided herein. Visual analytics techniques are provided that combine pattern mining and temporal event visualization-based techniques. Visual episode query tools allow interactive specification of episode definitions and are combined with on-demand data analytics that perform pattern mining to help discover important intermediate events within an episode, and dynamic information visualization that allow interactive exploration and analysis of clinical event sequence data. The disclosed interactive visualization techniques identify events that impact outcome and how those associations change over time. | 04-16-2015 |
20150106023 | TRAINING APPARATUS, TRAINING METHOD, AND PROGRAM - A training apparatus includes: a controller. The controller is configured to: (a) while a subject is performing a behavior, acquire time-series myoelectric potentials of each of muscles of the subject; (b) calculate a muscle synergy matrix W, a control matrix C and an error matrix E from a myoelectric potential matrix M so that the relationship M=WC+E is satisfied, row vectors each expressing the acquired time-series myoelectric potentials of a corresponding one of the muscles, m being arranged in rows in the myoelectric potential matrix, n unit column vectors being arranged in columns in the muscle synergy matrix W, n row vectors being arranged in rows in the control matrix; (c) calculate a feature quantity indicating consistency among the unit column vectors included in the calculated muscle synergy matrix W; and (d) output the calculated feature quantity. | 04-16-2015 |
20150106024 | SYSTEMS AND METHODS FOR DETERMINING IMPLANT POSITION AND ORIENTATION - A method for determining implant position and orientation comprises generating a plurality of predetermined criteria associated with a surgical procedure. The plurality of predetermined criteria including at least one of a mechanical alignment metric, a soft-tissue balancing metric, and a functional outcome metric. The method also comprises receiving one or more user selections of performance criteria, the one or more user-selections based on a user's desired outcome of the surgical procedure. At least one weighting factor associated with a simulation algorithm may be adjusted based on the received user selections of predetermined criteria. The method also includes simulating a patient-specific model, and determining performance metrics based on the user selected performance criteria. The information indicative of at least one of a recommended implant position or a recommended implant orientation may be provided for display to a graphical user interface, the information being based on the performance metrics. | 04-16-2015 |
20150106025 | Method and System for Determining and Communicating a Performance Measure Using a Performance Measurement System - A method implemented by a wearable performance measurement system, for determining and communicating a performance measure, includes selecting a mode of operation of the wearable performance measurement system from a plurality of configured modes of operations. Each mode of operation has a corresponding configured performance measure and configured feedback technique. At least one of the configured performance measure or the configured feedback technique is different for each mode of operation. The method also includes using a set of sensors of the wearable performance measurement system to detect at least one physical movement of a person. The method further includes, determining a type of physical activity from the at least one detected physical movement, and determining a performance measure corresponding to the selected mode of operation. The method also includes communicating an indication of the determined performance measure using the feedback technique corresponding to the selected mode of operation. | 04-16-2015 |
20150106026 | METHOD AND DEVICE FOR AUDIO RECORDING - An acquisition system includes a processor and one or more sensors coupled to the processor, where the one or more sensors monitor within an ear canal one or more of acceleration, blood oxygen saturation, blood pressure or heart-rate configured to monitor a biological state or a physical motion or both. The processor can be configured to analyze a portion of the biological state or the physical motion. Other embodiments are disclosed. | 04-16-2015 |
20150112602 | SYSTEMS AND METHODS FOR USING PAIRED-END DATA IN DIRECTED ACYCLIC STRUCTURE - Methods of analyzing a transcriptome that involves obtaining at least one pair of paired-end reads from a transcriptome from an organism, finding an alignment with an optimal score between a first read of the pair and a node in a directed acyclic data structure (the data structure has nodes representing RNA sequences such as exons or transcripts and edges connecting pairs of nodes), identifying candidate paths that include the node connected to a downstream node by a path having a length substantially similar to an insert length of the pair of paired-end reads, and aligning the paired-end rends to the candidate paths to determine an optimal-scoring alignment. | 04-23-2015 |
20150112603 | MOBILE DEVICE BASED GAIT BIOMETRICS - A system and method for identifying an individual based, at least in part, on their gait is presented. First, acceleration data is received from an accelerometer carried by a person. The acceleration data corresponds to a gait of the person. Rotational invariant values that are independent of a rotational position of the accelerometer are calculated based, at least in part, on the acceleration data. A gait dynamics image (GDI) is calculated based, at least in part, on the rotational invariant values. The GDI is matched to one of a set predetermined GDIs to identify the person. | 04-23-2015 |
20150112604 | VISUALLY AUGMENTING A GRAPHICAL RENDERING OF A CHEMICAL STRUCTURE REPRESENTATION OR BIOLOGICAL SEQUENCE REPRESENTATION WITH MULTI-DIMENSIONAL INFORMATION - In certain embodiments, the invention relates to systems, methods, and apparatus that allow a user to visually augment a graphical rendering of either a chemical structure representation or a biological sequence representation with multi-dimensional information. A user captures a video image using a computing device such as a hand-held smart phone, computerized eye glasses or tablet computer. The video image includes information regarding at least one of a chemical structure and a biological sequence. A processor identifies, within the video image, a graphical representation of at least one of a chemical structure and a biological structure. The processor augments the graphical representation with additional information and provides the video data for presentation upon a display controlled by the computing device. The computing device presents the video data in substantially real time in relation to the capture of the video data by the computing device. | 04-23-2015 |
20150112605 | SYSTEMS AND METHODS FOR GENERATING RESPIRATION ALARMS - Systems and methods are provided for generating respiration alarms. Respiration information and oxygen saturation information is determined from a photoplethysmograph (PPG) signal. This information is analyzed in connection with activating a respiration lost alarm. | 04-23-2015 |
20150112606 | Calculating Pulse Transit Time - The technology described in this document is embodied in a method that includes obtaining a first data set representing time-varying information on at least one pulse pressure wave at a first body part of a subject. The method also includes obtaining a second data set representing time-varying information about motion of the subject at the first body part of a subject. The method also includes identifying a first point in the first data set, the first point representing an arrival time of the pulse pressure wave at the first body part, and identifying a second point in the second dataset, the second point representing an earlier time at which the pulse pressure wave traverses a second body part of the subject. The method also includes computing a pulse transit time (PTT) as a difference between the first and second points. | 04-23-2015 |
20150112607 | SYSTEMS AND METHODS FOR RARE DISEASE PREDICTION AND TREATMENT - A rare disease matching and prediction portal is provided where a number of symptoms are matched with a list of rare diseases to produce candidate diseases, after which the candidate diseases are evaluated based on weighted lists of symptoms for each candidate disease to produce a confidence indicating a likelihood that a patient suffers from one of the rare diseases. Information curated from publications and other curated databases related to rare diseases are utilized to determine the weighted list of symptoms for each disease based on prevalence relevance of each symptom to each candidate disease, and a customized algorithm is applied to determine the confidences for the candidate diseases. Along with the confidences, the portal may provide a disease profile for each disease which includes possible treatments for the candidate diseases. The patient may then be treated for at least one of the candidate diseases based on the confidences. | 04-23-2015 |
20150120201 | CPR Chest Compression Monitor for Infants - Methods and devices for chest compression depth measurement for CPR performed on infants. | 04-30-2015 |
20150120202 | SYSTEM AND METHOD FOR TRACKING BIOLOGICAL AGE OVER TIME BASED UPON HEART RATE VARIABILITY - A system and method for tracking biological age over time based upon heart rate variability includes an activity monitoring device configured to measure and transmit one or more biological age parameters, including heart rate variability, to a biological age calculation and display module configured to calculate a biological age factor as a function of the biological age parameters, calculate biological age as a function of the biological age factor and the user's actual age, and display the biological age. | 04-30-2015 |
20150120203 | SYSTEM AND METHOD FOR IDENTIFYING FATIGUE SOURCES - A system for identifying fatigue sources includes a processor and at least one computer program residing on the processor. The computer program is stored on a non-transitory computer readable medium having computer executable code embodied thereon. The computer executable code is configured to detect a fatigue level. The computer executable code is further configured to receive fatigue contribution data. In addition, the computer executable code is configured to identify a fatigue source based on the fatigue level and the fatigue contribution data. | 04-30-2015 |
20150120204 | TRANSCRIPTOME ASSEMBLY METHOD AND SYSTEM - Provided is a transcriptome assembly method, comprising the following steps of: constructing a sequencing sample transcriptome read into a de Brujin graph; performing filtering and linearization processing on the de Brujin graph, so as to form continuous contigs; obtaining association among the contigs, and filtering association data; performing linearization processing on a continuous sequence without bifurcation; outputting a contig sequence; comparing the read and an end pairing read with the output contig sequence, so as to obtain information between the read and the contig; establishing connections among the contigs, so as to construct a graph with the contigs as points and the connections as edges; pre-processing and dividing the obtained graph, so as to obtain independent sub-graphs; and outputting a transcript according to the sub-graphs. Further provided is a transcriptome assembly system based on the method. | 04-30-2015 |
20150120205 | SYSTEM AND METHOD FOR MANAGING STRESS - A device for managing user stress is provided. The device includes a collection unit that collects stress related information, an analysis unit that determines a stress state, and an expression unit provides a stress related expression to a user. The collection unit may receive feedback from the user, and the feedback may be used for determining the stress state. | 04-30-2015 |
20150120206 | CONSTITUTIONAL DISEASE PATTERN DETERMINATION METHOD AND APPARATUS - Provided is a constitutional disease pattern determination apparatus including a calculator to calculate a first deficiency and excess index and a first cold and heat condition index of a user based on clinical information on the user, and a determiner to determine, based on a first reference table corresponding to a first constitution, a first constitutional disease pattern corresponding to the first deficiency and excess index and the first cold and heat condition index among a plurality of constitutional disease patterns included in the first reference table, wherein the first constitution is a constitution classified to correspond to the user based on a Sasang constitution. | 04-30-2015 |
20150120207 | Cardiac Mapping System And Method For Voltage-Based Evaluation Of Electrograms - Systems and methods for evaluating electrograms are described. An example method of evaluating an electrogram such as an atrial and/or ventricular electrogram containing a plurality of data samples each having a voltage includes selecting an activity interval for the electrogram, calculating an energy level for each window of a plurality of windows of the electrogram based on the voltages of the data samples in each window, assigning the calculated energy levels to a plurality of bins, and calculating an index based at least in part on a number of energy levels assigned to a particular bin of the plurality of bins. | 04-30-2015 |
20150120208 | SYSTEM AND METHOD FOR ALIGNING GENOME SEQUENCE IN CONSIDERATION OF ACCURACY - There are provided a sequence aligning device in consideration of accuracy, and a method thereof. The sequence aligning apparatus of an embodiment of the present disclosure includes a seed extracting unit configured to extract at least one seed that is exactly matched to a reference sequence from a read; a mapping score calculating unit configured to, with respect to each of the at least one extracted seed, map a left area and a right area of the read to the reference sequence based on the seed at each mapping position of the reference sequence of each seed, and calculate a left mapping score and a right mapping score of each mapping position from the mapping result; and a read aligning unit configured to determine a mapping position in each reference sequence of the at least one seed using the calculated left mapping score and right mapping score. | 04-30-2015 |
20150127265 | DEVICE FOR CALCULATING AMOUNT OF RETAINED PHYSICAL ACTIVITY, METHOD FOR CALCULATING AMOUNT OF RETAINED PHYSICAL ACTIVITY AND SYSTEM FOR CALCULATING AMOUNT OF RETAINED PHYSICAL ACTIVITY - A physical activity consumption amount calculation unit calculates the consumption amount of physical activity, which is the amount of physical activity consumed by a subject, from biological information acquired by a biological information acquisition unit. A recovery amount calculation unit calculates the amount of recovery, which is the amount of physical activity recovered by the subject, from the biological information acquired by the biological information acquisition unit. A retained physical activity amount calculation unit calculates the amount of retained physical activity, which is the amount of physical activity retained by the subject, from the reference amount of physical activity set by the reference physical activity amount setting unit, the consumption amount of physical activity calculated by the physical activity consumption amount calculation unit, and the amount of recovery calculated by the recovery amount calculation unit. Therefore, the amount of physical activity retained by the subject can be calculated instantaneously. | 05-07-2015 |
20150127266 | Method for Assessment of Orthodontic Treatment - A method for assessment of orthodontic treatment for a patient include: calculating a first feature value according to a facial profile of the patient; calculating a second feature value according to a facial midline of the patient and a mesial surface of one of anterior teeth in an orthodontic quadrant; calculating a space value according to a difference between an arch length of a dental arch portion of the orthodontic quadrant, and a sum of mesiodistal diameters of crowns of teeth encompassed by the dental arch portion; and calculating an assessment value indicating a proposed displacement for a molar in the orthodontic quadrant according to the space value and the first and second feature values. | 05-07-2015 |
20150127267 | MULTIPLE-MARKER RISK PARAMETERS PREDICTIVE OF CONVERSION TO DIABETES - Methods, systems and circuits evaluate a subject's risk of developing type 2 diabetes using defined mathematical models of short term risk (STR) and longer term risk of progression. The evaluations can stratify risk for patients having the same glucose measurement, particularly those with intermediate or low (normal) fasting plasma glucose (FPG) values. The STR or IR (insulin resistance) model(s) may include an inflammatory biomarker such as an NMR derived measurements of GlycA and a plurality of selected lipoprotein components of at least one biosample of the subject. Embodiments of the invention also provide methods, systems and circuits that generate STR scores as a marker of beta-cell dysfunction or impairment. | 05-07-2015 |
20150127268 | Methods, Systems and Devices for Activity Tracking Device Data Synchronization With Computing Devices - Methods, devices and system are provided. One method includes capturing activity data associated with activity of a user via a device. The activity data is captured over time, and the activity data is quantifiable by a plurality of metrics. The method includes storing the activity data in storage of the device and, from time to time, connecting the device with a computing device over a wireless communication link. The method defines using a first transfer rate for transferring activity data captured and stored over a period of time. The first transfer rate is used following startup of an activity tracking application on the computing device The method also defines using a second transfer rate for transferring activity data from the device to the computing device for display of the activity data in substantial-real time on the computing device. | 05-07-2015 |
20150134261 | SYNCHRONIZATION OF PATIENT MOTION DETECTION EQUIPMENT WITH MEDICAL IMAGING SYSTEMS - An improved system and method to acquire physiological information about a state of a subject, such as SPECT and PET information. The system generates a predetermine sequence of pulse signals and combines that sequence with a first physiological signal to generate a time-base signal. The time-base signal is than combined with a second physiological signal. The combined signals are analyzed to determine accurate temporal synchronization of the first and second physiological signals. The system can be generalized to handle more than two physiological signals. Examples of physiological signals can be for example EKG signals, tomography signals, gross-body motion signals, respiratory motion signals, voluntary motion signals, involuntary motion signals and other signals. The analyzed data can be displayed and/or recorded, and provides physiological information about a state of the subject. | 05-14-2015 |
20150134262 | SYSTEMS AND METHODS FOR STORING, PROCESSING AND UTILIZING PROPRIETARY GENETIC INFORMATION - A method of genetic testing utilizing a system of servers, databases, computers, software applications, or any other computing module. The computing modules allow for creation of a genetic test script and the analysis of genetic information based on the genetic test script. The system can also account for the use of proprietary biomarkers. | 05-14-2015 |
20150134263 | INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND RECORDING MEDIUM - There is provided an information processing apparatus including: an input unit inputting first vibration information observed from a moving body; a generating unit generating second vibration information based on a periodic function including at least one parameter that models periodic motion of the moving body; and an estimating unit estimating the at least one parameter based on a comparison result for the first vibration information inputted by the input unit and the second vibration information generated by the generating unit. The estimating unit repeatedly estimates the at least one parameter based on a comparison result for the first vibration information and the second vibration information that has been regenerated by the generating unit using the estimated at least one parameter. | 05-14-2015 |
20150134264 | Systems and Methods for Detecting Truth Utilizing Biologic Data - Systems and methods for detecting truth utilizing biologic data observed during various time periods occurring prior and subsequent to the presentation of a stimulus to a subject and/or prior and subsequent to a volitional action performed by the subject in response to the stimulus. A method for creating a truth or lie scale involving: presenting a stimulus designed to evoke an action to a subject; monitoring a first change in biologic data between a first epoch and a second epoch, the first epoch occurring during presentation of the stimulus, and the second epoch occurring subsequent to presentation of the stimulus; monitoring a second change in biologic data between a second epoch and a third epoch, the third epoch occurring subsequent to the action performed by the subject; and analyzing the monitored data to create the truth or lie scale. | 05-14-2015 |
20150134265 | MEDICAL DEVICE SYSTEM PERFORMANCE INDEX - A distributed network system and method includes a processing unit configured to manage safety data for a plurality of medical devices, a database software component in communication with the processing unit, and a monitoring software component in communication with the processing unit. The monitoring software component is configured to monitor a number of messages between a number of medical devices and the processing unit, to process performance parameters to generate an overall performance index, and to generate an output that is viewable by a user. The output includes relative contributions of each of the performance parameters to the overall performance index, where the overall performance index is generated using a weighting factor associated with each of the performance parameters. The performance parameters include the number of messages waiting to be processed, which has the largest weighting factor, and a disk queue length, which has the smallest weighting factor. | 05-14-2015 |
20150134266 | METHOD OF IDENTIFYING THE MOLECULAR BASIS OF THE ACTIVITY OF A DRUG COMPOUND, PHARMACEUTICAL COMPOSITIONS, AND TREATMENT METHODS - The present invention relates to a method of identifying the molecular basis of a drug compound's activity. The invention further relates to a pharmaceutical composition, a kit for treating psychosis in a subject, and a method for treating psychosis and/or schizophrenia. | 05-14-2015 |
20150134267 | AUTOMATED NUCLEIC ACID REPEAT COUNT CALLING METHODS - The present disclosure relates to processes for determining the number of nucleic acid repeats in a DNA fragment comprising a nucleic acid repeat region. One example method may include receiving DNA size and abundance data generated by resolving DNA amplification products. A set of low-pass data may be generated by applying a low-pass filter to the DNA size and abundance data and a set of band-pass data may be generated by applying a band-pass filter to the DNA size and abundance data. A peak of the DNA size and abundance data representative of a number of nucleic acid repeats in the DNA may be identified based on peaks identified from the low-pass data and the band-pass data. | 05-14-2015 |
20150134268 | PORTABLE MONITORING DEVICES AND METHODS OF OPERATING SAME - The present inventions, in one aspect, are directed to a portable activity monitoring device comprising a housing having a physical size and shape that is adapted to couple to the user's body, a plurality of sensors (for example, motion sensor and altitude sensor) disposed in the housing. The monitoring device may further include processing circuitry, disposed in the housing and electrically coupled to the plurality of sensor, to calculate the activity points corresponding to the physical activity of the user using the sensor data, wherein the activity points correlate to an amount and intensity of the physical activity of the user, and output the data which is representative of the activity points. The monitoring device may also include a display, coupled to the processing circuitry, may output the data which is representative of the activity points to the user. | 05-14-2015 |
20150142323 | METHOD AND SYSTEM FOR DETERMINING AN AMPLIFICATION QUALITY METRIC - According to one exemplary embodiment, a method for providing a amplification quality metric to a user is provided. The method includes receiving amplification data from an amplification of a sample to generate an amplification curve. The amplification curve includes an exponential region and a transition region. The method further includes determining a first value of the transition region and determining a second value of the transition region. The first value is the beginning of the transition region and the second value is the end of the transition region. Next, the amplification quality metric is calculated based on at least the first value and the second value. Then, the amplification quality metric is displayed to the user. | 05-21-2015 |
20150142324 | Healthbeat of plants - Health of plants depends on amount and quality of minerals in soil, sunlight, water moisture in soil etc. A novel technique is applied and results found to be very accurate. Months of various experimentations posed no harm to the sample plants of different species. An electronic system is successfully designed and tested to monitor the health status of plants that incorporating to plant's internal fluid's condition. Plants have their own characteristics that can indicate status of their health; herein, experiments also included samples of | 05-21-2015 |
20150142325 | METHOD, SYSTEM AND APPARATUS FOR SETTING INSULIN DOSAGES FOR DIABETICS - A more accurate method of determining a Carbohydrate to Insulin Ratio for an individual diabetic is provided. The individual, who has been using or has been given a prior suggested dosage of rapid-acting insulin to be taken prior to meals, first plans a benchmark meal (“the Meal”) and precisely counts the number of grams of carbohydrates which will be consumed in the meal. The individual blood glucose level is measured before the meal, then the previous dosage of rapid- acting insulin is injected. After the meal another reading is taken of the individual's blood sugar level. The number of units X of carbohydrates for each unit of rapid-acting insulin to be taken before future meal is then calculated by a unique formula. | 05-21-2015 |
20150142326 | SYSTEMS AND METHODS FOR IDENTIFYING THERMODYNAMICALLY RELEVANT POLYMER CONFORMATIONS - Systems, methods and non-transitory computer readable media identify favored polymer conformations. One or more residues are identified and may be replaced in the polymer, or the original primary sequence of the polymer may be retained. The conformations of residues in a subset of residues in a region of the identified one or more residues are altered. This conformational adjustment is repeated for other subsets of residues in the region of the identified one or more residues, and for other conformations, thereby deriving a plurality of polymer structures. A set of clusters is generated for each residue of the polymer using the conformationally adjusted structures, thereby creating sets of clusters. Structures in the plurality of structures are grouped into subgroups when the structures fall into the same clusters across a threshold number of the sets of clusters. One or more physical properties are determined for structures in subgroups, thereby identifying one or more thermodynamically relevant polymer conformations for the polymer. | 05-21-2015 |
20150142327 | METHOD FOR IMPROVING THE ACCURACY OF CHEMICAL IDENTIFICATION IN A RECOGNITION-TUNNELING JUNCTION - A method to identify a chemical target trapped in a tunnel junction with a high probability of a correct assignment based on, a single read of the tunnel current signal. The method recognizes and rejects background signals produced in the absence of target molecules, and do so accurately without rejecting useful signals from the target molecules. The identity of signals generated by electron tunneling through an analyte is provided and comprises determining a plurality of characteristics of each signal current spike, generating one or more training signals with a set of analytes, where the analytes may comprise a first analyte, and using the training signals to find one or more boundaries in a space of dimension equal to one or more parameters, wherein the space is partitioned such that a signal from the first analyte of interest is separated from a signal from the second analyte of interest. | 05-21-2015 |
20150142328 | CALCULATION METHOD FOR INTERCHROMOSOMAL TRANSLOCATION POSITION - The present invention relates to a method for calculating inter-chromosomal translocation position by using sequence read data generated through a next generation sequencing (NGS) apparatus. According to the present invention, the inter-chromosomal translocation position is determined more precisely and efficiently in base units. | 05-21-2015 |
20150142329 | METHOD AND SYSTEM FOR EXERCISE MONITORING - A portable data processing system includes a memory system, a processing system and a reception system for receiving data from acceleration sensors indicating test subject's acceleration in three orthogonal directions plus orientation of the acceleration sensors. The memory system includes routines for 1) determining instantaneous vertical, longitudinal and lateral accelerations from the received acceleration sensor data; 2) identifying periodicity in one of the instantaneous accelerations and using the periodicity with the instantaneous accelerations to determine dynamic movement parameters related to movement over ground, separately for both legs; 3) using a vertical energy loss and brake energy loss to determine a combined energy loss; and 4) outputting an indication of the combined energy loss and/or correction instructions. | 05-21-2015 |
20150142330 | DYNAMIC PERSONALIZED CANCER TREATMENT - An approach to personalized cancer treatment uses a selection of a sequence of treatments, which are selected, for example, using a global optimization and/or decision tree approach. For each selected treatment in the sequence, data characterizing expected growth and transition between different cell states (e.g., different phenotypes) is used to predict evolution of cell populations during application of the selected treatment. | 05-21-2015 |
20150142331 | METHODS AND DEVICES FOR ASSESSING RISK OF FEMALE INFERTILITY - The invention generally relates to methods and devices for assessing risk of female infertility. In certain aspects, methods of the invention involve obtaining a sample, conducting an assay on at least one infertility-associated biomarker, and assessing risk to the patient of developing early-onset decrease in fertility based upon results of the assay. | 05-21-2015 |
20150142332 | HEALTH CARE SYSTEM AND METHOD USING STRESS INDEX ACQUIRED FROM HEART RATE VARIATION - A health care system and method using human body indexes acquired from human body information are disclosed. The present health care method includes receiving human body information, calculating a human body index based on the received human body information, generating a health care program based on the calculated human body index and providing the generated health care program to a user. By this system and method, it becomes possible to measure and monitor stress/fatigue/health indexes of a user in living environments, thereby effectively supporting well-being life of the user. | 05-21-2015 |
20150142333 | METHOD FOR ANALYZING BIOLOGICAL SPECIMENS BY SPECTRAL IMAGING - A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components. | 05-21-2015 |
20150149094 | NMR QUANTIFICATION OF TMAO - A defined peak region residing between about 3.2 and 3.4 ppm of a proton NMR spectrum of an in vitro biosample is electronically evaluated to determine a level of trimethylamine-N-oxide (“TMAO”). The biosamples may be any suitable biosamples including human serum with a normal biologic range of between about 1-50 μM or urine with a normal biologic range of between about 0-1000 μM. | 05-28-2015 |
20150149095 | MULTI-PARAMETER DIABETES RISK EVALUATIONS - Methods, systems and circuits evaluate a subject's risk of developing type 2 diabetes or having prediabetes using at least one defined mathematical model of risk of progression that can stratify risk for patients having the same glucose measurement. The model may include NMR derived measurements of GlycA and a plurality of selected lipoprotein components of at least one biosample of the subject. | 05-28-2015 |
20150149096 | Precision dialysis monitoring and synchonization system - A device, system and related methods for monitoring a mammal with heart failure, kidney disease or both, to make predictions about the likelihood of a life threatening ventricular arrhythmia. The device, system and related methods can have one or more sensors in electronic communication with a processor, the sensors determining one or more physiological parameters of a patient, and communicating the physiological parameter to the processor, and the processors using an algorithm to determine the probability of a ventricular arrhythmia based on the physiological parameters. | 05-28-2015 |
20150293143 | Feature Extraction from Human Gaiting Patterns using Principal Component Analysis and Multivariate Empirical Mode Decomposition - The present invention, in some embodiments thereof, relates to a technique for extracting one or more features of a person's gait from acceleration and velocity measurements collected by motion sensors associated with the person. | 10-15-2015 |
20150294062 | Method for Identifying a Target Molecular Profile Associated with a Target Cell Population - A method for identifying a target molecular profile associated with a target cell population. A set of reference molecular profiles and a set of sample molecular profiles are received. Each sample molecular profile is associated with a sample cell from a sample cell population, which includes a mixture of target cells and reference cells. Each of the sample molecular profiles is indicative of a respective target molecular profile. An average target molecular profile is calculated. A proportion value is calculated for each sample molecular profile. A respective target molecular profile is calculated for each sample molecular profile based on the respective calculated proportion value and a closest similarity to the average target molecular profile. | 10-15-2015 |
20150294063 | DIAGNOSTIC GENETIC ANALYSIS USING VARIANT-DISEASE ASSOCIATION WITH PATIENT-SPECIFIC RELEVANCE ASSESSMENT - Relevance of a study genetic variant observed in diagnostic subject genetic data that is associated by a clinical study with a phenotype characteristic is assessed as follows. A set of polymorphisms functionally related to the study genetic variant are identified. A foreground distribution is computed of variants observed in the diagnostic subject genetic data for the set of polymorphisms. A background distribution is computed of variants observed in genetic data of subjects of the clinical study for the set of polymorphisms. A comparison metric is computed comparing the foreground distribution and the background distribution. Relevance of the study variant to the diagnostic subject is quantified based on the comparison metric, with higher similarity of the foreground and background distributions corresponding to higher relevance. | 10-15-2015 |
20150294064 | IDENTIFICATION, MONITORING AND TREATMENT OF INFECTIOUS DISEASE AND CHARACTERIZATION OF INFLAMMATORY CONDITIONS RELATED TO INFECTIOUS DISEASE USING GENE EXPRESSION PROFILES - A method is provided in various embodiments for determining a profile data set for a subject with infectious disease or inflammatory conditions related to infectious disease based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least 2 constituents from Table 1. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable. | 10-15-2015 |
20150294065 | Database-Driven Primary Analysis of Raw Sequencing Data - The present invention relates to methods for identifying the source of a biological sequence containing sample from raw sequencing reads. The method may be used to identify the source of unknown DNA and can be used for diagnostic, biodefense, food safety and quality, and hygiene applications. In another aspect the invention relates to a database of reference sequences which can be used in the method of the invention. | 10-15-2015 |
20150294074 | BRAIN ACTIVITY TRAINING APPARATUS AND BRAIN ACTIVITY TRAINING SYSTEM - Provided is a brain activity training apparatus for training to cause a change in correlation of connectivity among brain regions, utilizing measured correlations of connections among brains regions as feedback information. From measured data of resting-state functional connectivity MRI of a healthy group and a patient group (S | 10-15-2015 |
20150294080 | BALANCED ULTRAVIOLET LIGHT EXPOSURE RECOMMENDATIONS - Ultraviolet light poses both health benefits and health risks. A method, device and computer storage program balances the health risks and benefits ultraviolet light exposure with personal sensitivities and preferences for these health risks and benefits. An ultraviolet violet light exposure level of a subject person is estimated by monitoring data from a plurality of sources. A personal sensitivity to ultraviolet light exposure is also estimated from data from various sources. A recommendation for the subject person is generated based upon the estimated risks and benefits of ultraviolet light exposure. | 10-15-2015 |
20150297146 | Mulit-Sensor Patch and System - Embodiments of the invention provide systems and methods for remote sensing and/or monitoring utilizing a sensing device, such as may be implemented in a patch that can be placed on or affixed to a subject, where the sensing device includes multiple sensors. For example, one embodiment of the present invention includes a wireless human temperature skin patch providing accurate measurement of human temperature from a sensing device applied to the skin and even in the presence of differing ambient temperature. In such an embodiment, the patch can include, for example, a flexible, breathable bandage or adhesive strip or pad to affix the sensing device to a patient. The sensing device can include multiple sensors such as two or more temperature sensors that can be used to accurately determine the patient's core body temperature from the measured temperature at the skin. | 10-22-2015 |
20150302141 | MULTICELLULAR METABOLIC MODELS AND METHODS - The invention provides a computer readable medium or media, having: (a) a first data structure relating a plurality of reactants to a plurality of reactions from a first cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (b) a second data structure relating a plurality of reactants to a plurality of reactions from a second cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (c) a third data structure relating a plurality of intra-system reactants to a plurality of intra-system reactions between said first and second cells, each of said intra-system reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (d) a constraint set for said plurality of reactions for said first, second and third data structures, and (e) commands for determining at least one flux distribution that minimizes or maximizes an objective function when said constraint set is applied to said first and second data structures, wherein said at least one flux distribution is predictive of a physiological function of said first and second cells. The first, second and third data structures also can include a plurality of data structures. Additionally provided is a method for predicting a physiological function of a multicellular organism. The method includes: (a) providing a first data structure relating a plurality of reactants to a plurality of reactions from a first cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (b) providing a second data structure relating a plurality of reactants to a plurality of reactions from a second cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (c) providing a third data structure relating a plurality of intra-system reactants to a plurality of intra-system reactions between said first and second cells, each of said intra-system reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (d) providing a constraint set for said plurality of reactions for said first, second and third data structures; (e) providing an objective function, and (f) determining at least one flux distribution that minimizes or maximizes an objective function when said constraint set is applied to said first and second data structures, wherein said at least one flux distribution is predictive of a physiological function of said first and second cells. | 10-22-2015 |
20150302155 | METHODS AND SYSTEMS FOR PREDICTING HEALTH CONDITION OF HUMAN SUBJECT - Disclosed are the methods and systems for classifying one or more patients in one or more categories. A distribution of one or more physiological parameters associated with the one or more patients is determined based on a patient dataset. The one or more physiological parameters correspond to at least a stroke scale score. One or more parameters associated with a copula are estimated by the one or more processors. In an embodiment, the copula defines a joint distribution of the one or more physiological parameters. A classifier is created based on the one or more parameters, wherein the classifier classifies the one or more patients in the one or more categories. The one or more categories correspond to a range of the stroke scale score. | 10-22-2015 |
20150302158 | VIDEO-BASED PULSE MEASUREMENT - Aspects of the subject disclosure are directed towards a video-based pulse/heart rate system that may use motion data to reduce or eliminate the effects of motion on pulse detection. Signal quality may be computed from (e.g., transformed) video signal data, such as by providing video signal feature data to a trained classifier that provides a measure of the quality of pulse information in each signal. Based upon the signal quality data, corresponding waveforms may be processed to select one for extracting pulse information therefrom. Heart rate data may be computed from the extracted pulse information, which may be smoothed into a heart rate value for a time window based upon confidence and/or prior heart rate data. | 10-22-2015 |
20150302162 | CLOUD-ASSISTED REHABILITATION METHODS AND SYSTEMS FOR MUSCULOSKELETAL CONDITIONS - Embodiments of the invention include a cloud-assisted rehabilitation system for assisting in the rehabilitation of musculoskeletal conditions, and a method for rehabilitating patients having musculoskeletal conditions. A rehabilitation portal can aggregate and de-identified musculoskeletal rehabilitation information that is gathered from various intelligent musculoskeletal rehabilitation apparatuses attached to a group of patients. The rehabilitation portal can facilitate crowd communication among the group of patients. A particular rehabilitation experience can be compared with other rehabilitation experiences and data from other patients. The rehabilitation portal can also facilitate crowd communication among a group of healthcare professionals so that the plurality of healthcare professionals can communicate with each other and compare information regarding different rehabilitation experiences based at least on the aggregated de-identified musculoskeletal rehabilitation information. | 10-22-2015 |
20150302165 | DETECTION DEVICE, METHOD, AND PROGRAM FOR ASSISTING NETWORK ENTROPY-BASED DETECTION OF PRECURSOR TO STATE TRANSITION OF BIOLOGICAL OBJECT - The invention provides a detection device, method, and program capable of highly accurately detecting a pre-disease state that indicates a precursor to a state transition from a healthy state to a disease state. The following processes are carried out: a process of obtaining measured data on genes, proteins, etc. related to a biological object as high-throughput data (s | 10-22-2015 |
20150302169 | METHOD AND SYSTEM TO EXTEND THE CONDITIONS OF APPLICATION OF AN INVERSION OF THE HODGKIN-HUXLEY GATING MODEL - A method to quantify kinetics of voltage gated membrane channels by inversion of a Hodgkin Huxley formalism includes the steps of: providing an electrophysiology apparatus configured to provide a constant voltage difference across a cell membrane of a cell and to measure a current through the cell membrane and a computer configured to run at least one or more protocols; bounding R based on data generated by a T-step protocol or a G-step protocol; estimating a steady state based on data generated by a C-step protocol or a H step protocol; extracting a time constant based on the data generated by the T-step protocol or the G-step protocol as bounded by R; and assessing a range of time constants that can reproduce the data generated by the C-step protocol or the H step protocol and by the T-step protocol or the G-step protocol within and experimental error. C-step and a G-step voltage clamp stimulation protocols to generate a set of experimental data to quantify a channel availability of a cell are also described. | 10-22-2015 |
20150305636 | NON-RESISTIVE CONTACT ELECTRICAL SYSTEMS AND METHODS FOR VISUALIZING THE STRUCTURE AND FUNCTION OF OBJECTS OR SYSTEMS - Methods and systems for sensing properties of an object or entity utilize non-resistive contact sensors alone or in combination with other sensors. The sensor data is utilized for detecting and visualizing properties of one or more biological or non-biological objects or entities. | 10-29-2015 |
20150308973 | METHODS AND APPARATUS FOR MEASURING ELECTRICAL PROPERTIES OF CELLS - A method and an apparatus are disclosed for measuring the electrical properties of biological cells. The method involves a switching excitation with a sinusoidally amplitude-modulated current coupled with a real-time estimation algorithm for extracting a phase-shifted sinusoidal voltage output. The algorithm uses a unique time-domain formulation that provides accurate and continuous measurements with a high temporal resolution. The invention is suitable for measuring small signals under noisy conditions such as the membrane resistance and capacitance of a living cell accessed via a microelectrode. The resulting apparatus achieves a similar effect of a lock-in amplifier for suppressing noise but with a different approach. The invention also has the advantage that the input and the output can be decoupled by time-multiplexing on a single electrode. | 10-29-2015 |
20150309010 | BIOLOGICAL INFORMATION MEASURING DEVICE, BIOLOGICAL INFORMATION MEASURING SYSTEM USING SAME BIOLOGICAL INFORMATION MEASURING DEVICE, AND METHOD USING SAME BIOLOGICAL INFORMATION MEASURING DEVICE - A biological information measuring device comprises a sensor mounting portion that is provided to a main case and is used for mounting a sensor that measures biological information, a measurement component that is connected to the sensor mounting portion, a controller that is connected to the measurement component, a memory that is connected to the controller, and a timer. The controller associates measurement variance cause information acquired in a single measurement of biological information by the measurement component with the measurement results obtained by this single measurement, and stores the information in the memory. Accordingly, the user of the biological information measuring device can be prompted to use it properly. | 10-29-2015 |
20150310168 | METHOD FOR PREDICTING GENE CLUSTER INCLUDING SECONDARY METABOLISM-RELATED GENES, PREDICTION PROGRAM, AND PREDICTION DEVICE - This invention provides a method for predicting a gene cluster including secondary metabolism-related genes with high accuracy, independent of information concerning core genes. Such method comprises: a step of identifying a region the gene arrangement of which is conserved in nucleotide sequence information of another genome as a gene cluster on the basis of the results of homology search conducted with the use of nucleotide sequence information of at least a pair of genomes; and a step of determining whether or not the gene cluster of interest includes secondary metabolism-related gems on the basis of the proportion of synteny-like regions within the gene cluster identified by the above step. | 10-29-2015 |
20150310178 | DIAGNOSTIC METHODS AND DEVICES FOR CONTROLLING ACUTE GLYCEMIA - Devices, systems and methods for monitoring glycemic levels in a patient, by calculate a plurality of blood glucose values from a plurality of blood samples taken, calculating a quantile of the blood glucose values taken over a period of days; and creating a Lorenz plot for the blood glucose values in the quantile. | 10-29-2015 |
20150313480 | METHOD AND SYSTEM FOR CALCULATING STRAIN FROM CHARACTERIZATION DATA OF A CARDIAC CHAMBER - A method and system is provided for calculating a strain from characterization motion data. The method and system utilize an intravascular mapping tool configured to be inserted into at least one of the endocardial or epicardial space. The mapping tool is maneuvered to select locations proximate to surfaces of the heart, while collecting map points at the select locations to form a point cloud data set during at least one cardiac cycle. The method and system further include automatically assigning segment identifiers (IDs) to the map points based on a position of the map point within the point cloud data set. The method and system further select a first and second reference from a group of map points. Further, the method and system calculate a linear strain based on an instantaneous distance and a reference distance between the first and second references. | 11-05-2015 |
20150316404 | MEASUREMENT OF FLUID VOLUME OF A BLOOD OXYGENATOR IN AN EXTRACORPOREAL CIRCUIT - The present disclosure provides a method and apparatus for measuring or monitoring oxygenator blood volume of a treatment device such as an oxygenator by analyzing an indicator passing through the oxygenator blood volume. Measuring the oxygenator blood volume can be done externally of the vein or artery, or in tubing leading to a blood treatment system which carries the blood exterior of the body of the patient or within the body of the patient. The present system can also monitor tubing volume of flowing blood upstream or downstream of the blood treatment device. The present system thus provides for measuring the volume of an extracorporeal circuit and creates an opportunity to control circuit performance and give an early warning of clotting to improve the quality of a variety of extracorporeal procedures with the use of relatively simple technology. | 11-05-2015 |
20150316626 | METHOD AND SYSTEM FOR ESTIMATING THE SPECIFIC ABSORPTION RATE OF A TISSUE REGION PRIOR TO A MAGNETIC RESONANCE IMAGING SCAN - A method and system for estimating a specific; absorption rate of a tissue region prior to performing a magnetic resonance (MR) imaging scan on the tissue region. The method comprises radiating the tissue region with a plurality of short pulses, wherein the tissue region emits thermoacoustic signals responsive to the short pulses, receiving the thermoacoustic signals by at least one ultrasonic transducer, calculating a temperature rise of the tissue region based on the received thermoacoustic signals, scaling the temperature rise to estimate a temperature rise of the tissue region resulting from an MR imaging scan, and estimating the specific absorption rate of the tissue region based on the estimated temperature rise. | 11-05-2015 |
20150316676 | SYSTEM AND METHOD FOR DETECTING INTERPERSONAL TOUCH USING ELECTRICAL PROPERTIES OF SKIN - Disclosed herein is an accurate and efficient, yet non-obtrusive system and method (using same) for detecting interpersonal touch, such as a high-five, which is prevalent in people's daily lives, so as to promote everyday interactions at diverse settings. Based on ubiquitous computing technology, one embodiment of the system for detecting interpersonal touch comprises a pre-motion filter for filtering a pre-motion prior to the interpersonal touch, a sensor for sensing electrical properties of skin, an evaluator for analyzing and determining the interpersonal touch based on the pre-motion and the electrical properties of skin, and a communicator for communicating information analyzed by the evaluator. Other embodiments are described and shown. | 11-05-2015 |
20150317432 | SYSTEM AND METHOD FOR THE COMPUTATIONAL PREDICTION OF EXPRESSION OF SINGLE-GENE PHENOTYPES - In accordance with an embodiment of the invention, a system and method is provided for determining a probability of a progeny having one or more phenotypes Ph | 11-05-2015 |
20150317433 | USING DOUBLET INFORMATION IN GENOME MAPPING AND ASSEMBLY - Systems, methods, and apparatuses are provided for determining a sequence of a heteropolymer molecule. For example, all or part of a chromosome or a protein can be determined using sequence data from a plurality of heteropolymer fragments corresponding to the heteropolymer molecule. As one example, a position in the sequence read of a DNA fragment can be identified where a single base call is not clear. A multiplet base call can then be used, where the multiplet base call includes two or more bases at the position, along with a score for each base. The scores can be carried through mapping and assembly procedures, where the scores can be used to determine a final base call for the position in a chromosome of a genome of an organism. Other examples can be used for other monomer units besides bases. | 11-05-2015 |
20150317438 | SUPPORTING THE MONITORING OF A PHYSICAL ACTIVITY - Improved techniques and systems for utilizing a portable electronic device to monitor, process, present and manage data captured by a remote sensor during a physical activity session are disclosed. The portable electronic device offers a convenient user interface that can be visual and/or audio based customized to a particular application, user-friendly and/or dynamic. The portable electronic device can pertain to a personal media device and thus also provide media playback. | 11-05-2015 |
20150317443 | METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR DETERMINING A PATIENT RADIATION AND DIAGNOSTIC STUDY SCORE - A method for determining a patient radiation and diagnostic study score associated with past diagnostic radiologic tests. In light of the obvious benefits of diagnostic radiology, the risks inherent in its use are often overlooked. Ionizing radiation, which is a component of much, but not all, diagnostic radiology, carries with it a small risk of inducing cancer every time it is used. This additional risk, known as “Lifetime Attributable Risk,” is layered on top of an individual's lifetime base risk of invasive cancer. The present method for determining a patient radiation and diagnostic study score provides right time, right place, and right format radiology information to assist providers in their medical decision-making. With greater awareness of recent study history, and individually contextualized risk and benefit considerations, providers are more likely to decrease their overall usage of diagnostic radiology and better counsel their patients on future risk. | 11-05-2015 |
20150317447 | METHOD FOR PREDICTION OF A PLACEBO RESPONSE IN A INDIVIDUAL SUFFERING FROM OR AT RISK TO A PAIN DISORDER - A method for predicting a placebo response in an individual, suffering from or at risk of developing a pain disorder is described. Data is collected from the individual by querying the individual on personality and/or health traits, or performing one or more social learning and/or (bio)physical tests on said individual. | 11-05-2015 |
20150317448 | METHOD AND SYSTEM TO AUTOMATICALLY ASSIGN MAP POINTS TO ANATOMICAL SEGMENTS AND DETERMINE MECHANICAL ACTIVATION TIME - A method and system are provided for assigning map points to anatomical segments of a heart. The method and system utilize an intravascular mapping tool configured to be inserted into at least one of the endocardial or epicardial space. The mapping tool is maneuvered to select locations proximate to surfaces of the heart, while collecting map points at the select locations to form a ROI data set. The method and system store the ROI data set in a data storage and defines apical, basal and circumferential landmarks within the ROI data set. The method and system automatically calculate circumferential and longitudinal segment boundaries, associated with wall segments of the heart, based on the apical, basal and circumferential landmarks. The method and system automatically assign segment identifiers (IDs) to the map points based on locations of the map points relative to the circumferential and longitudinal boundaries, the segment IDs associated with wall segments of the heart. | 11-05-2015 |
20150323464 | Apparatus based on a Hand-Held Raman Laser Device Integrating Multiple Functional Systems for Distant Life-Death Determination - Multiple functional systems are integrated to configure a portable handheld decision-aid device for first responder medics. Fuzzy membership functions of “life” and “death” are used to determine the status of fallen people using remote measurements. EO/IR cameras can be used to detect and identify casualties in a mass injury situation, while also estimating body temperature. Using the temperature, along with the remote estimation of a second vital sign, the life membership proportion can be estimated from the ground truth by using a 2D projection of stable vital signs. The other fuzzy membership function, death, can be estimated by the presence or absence of peri-mortem and post-mortem molecules. These molecules are only released after death and provide a certain indication of death. Solid state UV laser resonance Raman backscattering from these molecules allows the device to analyze the molecules present in a plume around the casualty. | 11-12-2015 |
20150323503 | METHOD AND SYSTEM OF ASSESSING OR ANALYZING MUSCLE CHARACTERISTICS INCLUDING STRENGTH AND TENDERNESS USING ULTRASOUND - A method and system of predicting a muscle characteristic using ultrasound. The characteristic may include a tenderness characteristic and/or a strength characteristic. An analysis of muscle structure is performed for a sample using ultrasound data of the sample. The analysis may include determining a relative number of bundles, fascicles, sarcomeres, fibers, and/or sheath thickness from the ultrasound data. Thereafter, the muscle characteristic is predicted for the sample based on the analysis. | 11-12-2015 |
20150330926 | HAND-HELD TEST METER CONSTANT CURRENT DRIVER WITH INTEGRATED TEST STRIP SAMPLE DETECTION - A hand-held test meter for the determination of an analyte in a bodily fluid sample using an analytical test strip includes a microprocessor block (MB), a strip port connector (SPC), a voltage driver block (VDB) operatively connected to the MB and the SPC, a current measurement block (CMB) operatively connected to the SPC and the MB, and a memory block operatively coupled to the MB and storing integrated test strip detection and constant current driver instructions. Moreover, the memory block, MB, VDB and CMB are configured such that the integrated test strip detection and constant current driver instructions, when executed by the MB, algorithmically detects sample application to a test strip inserted in the SPC and algorithmically drives a constant current through the inserted strip by varying a voltage applied to the SPC by the VDB based on a signal from the CMB. | 11-19-2015 |
20150332016 | BRAIN INFORMATION PROCESSING APPARATUS AND BRAIN INFORMATION PROCESSING METHOD - Conventionally, it is impossible to detect an object to which a person feels a similar sense based on latent consciousness. Detection of an object to which a person feels a similar sense is realizable by a brain information processing apparatus using high-level brain activity information indicating a latent consciousness. The brain information processing apparatus has stored therein one or more pieces of brain information that includes brain activity information, which is information on a brain activation level, and object information, and includes: an accepting unit that accepts brain activity information; an object information acquisition unit that acquires one or more pieces of object information associated with one or more pieces of brain activity information that is approximate to the brain activity information to the extent of satisfying a predetermined condition; and an output unit that outputs the object information acquired by the object information acquisition unit. | 11-19-2015 |
20150332020 | SYSTEMS AND METHODS OF MANAGING TREATMENT OF A CHRONIC CONDITION BY SYMPTOM TRACKING - Devices, systems, and methods for use in managing treatment of a chronic disorder with pharmaceutical or therapeutic compounds by tracking symptoms associated with the disorder. Methods include inputting patient attributes, factors and various and other data relating to the patient in conjunction with one or more symptoms into a symptom tracking system and outputting a report of the data tracked over time to any of the patient, a medical professional and a drug developer to improve identification of a relapse of the chronic condition and improve management of the treatment regimen for any and all patients. | 11-19-2015 |
20150335280 | System and Method of Biomechanical Posture Detection and Feedback Including Sensor Normalization - A system and method are described herein for a sensor device which biomechanically detects in real-time a user's movement state and posture and then provides real-time feedback to the user based on the user's real-time posture. The feedback is provided through immediate sensory feedback through the sensor device (e.g., a sound or vibration) as well as through an avatar within an associated application with which the sensor device communicates. The sensor device detects the user's movement state and posture by capturing data from a tri-axial accelerometer in the sensor device. Streamed data from the accelerometer is normalized to correct for sensor errors as well as variations in sensor placement and orientation. Normalization is based on accelerometer data collected while the user is wearing the device and performing specific actions. | 11-26-2015 |
20150339437 | DYNAMIC GENOME REFERENCE GENERATION FOR IMPROVED NGS ACCURACY AND REPRODUCIBILITY - A “dynamic” reference is presented that utilizes population level information to improve reference-based alignment to detect novel, deleterious, or functional variants in clinical sequencing applications. An automatically updated database of known genetic variants is provided to a memory connected with an integrated circuit configured for genetic sequence data with the dynamic reference and reference variants. | 11-26-2015 |
20150339438 | ANALYSIS SYSTEM AND COMPUTER IMPLEMENTED METHOD FOR ANALYZING BIOLOGICAL SAMPLES - Analysis system and computer implemented method for analyzing biological samples are disclosed. The system has at least one analyzer for performing an analysis and a decision unit being operable to determine in response to the receipt of the analysis request whether results obtained from performing the analysis on the sample indicated in the analysis request are valid. This determination is executed by retrieving the meta information assigned to the sample and by applying the at least one condition on the meta information and wherein the at least one applied condition has at least a condition on whether the sample allows a valid analysis on the sample, and wherein the decision unit returns the decision that the analysis exercised on the indicated sample will return a valid result in case the conditions of the condition set are met by the sample. | 11-26-2015 |
20150339439 | Method and System for Matching Probabilistic Identitypes on a Database - The present invention pertains to a process for matching biological items using a database. Specifically, the process comprises the steps of developing from genetic data a genotype for a biological item, together with a probability distribution over possible genotype allele pair values; (b) storing the item's genotype values and probability distribution on a computer database in a non-transitory memory; (c) storing a population probability distribution on the computer database; (d) specifying a match rule that defines a comparison between a first set of genotypes and a second set of genotypes stored on the database; (e) forming from the two sets of genotypes defined by the match rule, with a computer in communication with the database, pairs of genotypes that correspond to pairs of biological items; (f) partitioning the genotype pairs into disjoint groups that include all the pairs and do not overlap, ensuring that the number of pairs in each group remains bounded; (g) calculating, with a computer in communication with the database, for each genotype pair in the disjoint group, a match statistic that uses the genotype probability distributions; and (h) storing on the database a pair of genotypes, together with a match statistic that quantifies a strength of association between the corresponding pair of biological items. This probabilistic identitype database matching is useful for connecting objects to one another based on measuring their attributes. A probabilistic genotype database provides more accurate matching for DNA mixtures than does the FBI's prevalent CODIS database. | 11-26-2015 |
20150339448 | Methods for Screening, Predicting and Monitoring Prostate Cancer - Biomarkers are identified by analyzing gene expression data using support vector machines (SVM) to rank genes according to their ability to separate prostate cancer from normal tissue. Expression products of identified genes are detected in patient samples, including prostate tissue, serum, semen and urine, to screen, predict and monitor prostate cancer. | 11-26-2015 |
20150339449 | CELL-BOUND COMPLEMENT ACTIVATION PRODUCTS AS DIAGNOSTIC BIOMARKERS FOR PRE-LUPUS - Cell-bound complement activation product (CB-CAP) profiling and scoring serve as diagnostic biomarkers for patients to determine whether a patient who has not met at least four American College of Rheumatology (or similar e.g. SLICC) criteria for a definite Lupus diagnosis should be classified as exhibiting a pre-existing condition that this document refers to as pre-Lupus. | 11-26-2015 |
20150346210 | MULTIPLEX ASSAY FOR IMPROVED SCORING OF TUMOR TISSUES STAINED FOR PD-L1 - Multiplex assays for improved scoring of tumor tissues stained with PD-L1 featuring PD-L1 staining in a first color plus staining of one or more differentiating markers, such as a marker specific for tumor cells and a marker specific for immune cells, are disclosed. The differentiation between the tumor cells and immune cells may improve the ease of scoring, the accuracy and speed of scoring, and the reproducibility of scoring of PD-L1 positive samples for therapy purposes. | 12-03-2015 |
20150346302 | METHOD AND SYSTEM FOR SIGNAL PROCESSING - Aspects of the disclosure provide a system for signal processing. The system includes a selection circuitry and a coordination detection circuitry. The selection circuitry is configured to receive data sets sampled at different time for a subject and select a plurality of data units from each data set that corresponds to regions of interests in the data set. The coordination detection circuitry is configured to receive the selected data units corresponding to the regions of interests over time, and detect a coordination of the regions of interests over time. | 12-03-2015 |
20150347674 | SYSTEM AND METHOD FOR ANALYZING BIOLOGICAL SAMPLE - There are provided a system and method for analyzing a biological sample. The system for analyzing a biological sample according to an embodiment of the present disclosure includes a first variation detecting unit configured to determine whether a plurality of pools each have a test target property according to a first determining reference value; an error determining unit configured to determine whether there is an error possibility in a determination result of the first variation detecting unit according to an alternative allele frequency of a pool that is determined as positive in a determination result of the first variation detecting unit; a second variation detecting unit configured to determine whether each of the plurality of pools has the test target property according to a second determining reference value when it is determined in the error determining unit that there is the error possibility; and a test result determining unit configured to determine whether each of the plurality of samples has the test target property according to determination results of the first variation detecting unit and the second variation detecting unit. | 12-03-2015 |
20150347675 | NOISE REDUCTION METHODS FOR NUCLEIC ACID AND MACROMOLECULE SEQUENCING - Methods, systems, and devices are disclosed for processing macromolecule sequencing data with substantial noise reduction. In one aspect, a method for reducing noise in a sequential measurement of a macromolecule comprising serial subunits includes cross-correlating multiple measured signals of a physical property of subunits of interest of the macromolecule, the multiple measured signals including the time data associated with the measurement of the signal, to remove or at least reduce signal noise that is not in the same frequency and in phase with the systematic signal contribution of the measured signals. | 12-03-2015 |
20150347678 | METHODS AND SYSTEMS FOR DETECTING SEQUENCE VARIANTS - The invention provides methods for identifying rare variants near a structural variation in a genetic sequence, for example, in a nucleic acid sample taken from a subject. The invention additionally includes methods for aligning reads (e.g., nucleic acid reads) to a reference sequence construct accounting for the structural variation, methods for building a reference sequence construct accounting for the structural variation or the structural variation and the rare variant, and systems that use the alignment methods to identify rare variants. The method is scalable, and can be used to align millions of reads to a construct thousands of bases long, or longer. | 12-03-2015 |
20150347680 | SYSTEMS, METHODS AND COMPUTER READABLE STORAGE MEDIA FOR ANALYZING A SAMPLE - Methods, systems, and computer readable storage media relate to processing and analyzing a sample to determine presence or concentration of at least one sensor target in a sample. A method of quantifying a sample using a sensor may include obtaining sensor data, the sensor data including in-situ calibration data from a housekeeping protein; analyzing the sensor data; and outputting results of the analyzing. The method may be used with a system that includes a sensing device and a module. The system may also include an analysis device that can be in communication with the sensing device. | 12-03-2015 |
20150347702 | Image Analysis for Breast Cancer Prognosis - Heterogeneity for biomarkers in a tissue sample can be calculated. A heterogeneity score can be combined with an immunohistochemistry combination score to provide breast cancer recurrence prognosis. Heterogeneity can be based on percent positivity determinations for a plurality of biomarkers according to how many cells in the sample stain positive. An immunohistochemistry combination score can be calculated. An imaging tool can support a digital pathologist workflow that includes designating fields of view in an image of the tissue sample. Based on the fields of view, a heterogeneity metric can be calculated and combined with an immunohistochemistry combination score to generate a breast cancer recurrence prognosis score. | 12-03-2015 |
20150347716 | Method for Supervising Consumption of a Medical Food for Prevention and/or Management of a Disease or Condition - A method for supervising a patient during prevention and/or management of a disease or condition involving a medical food having greater than 60% pure eicosapentaenoic acid. | 12-03-2015 |
20150356238 | Scoring the Deviation of an Individual with High Dimensionality from a First Population - Techniques for scoring deviations of individuals from a population include obtaining profile data for each individual in a first population and from a subject drawn from a second population. The profile data indicates values for each of multiple parameters. Within the first population, a first neighbor and a second neighbor are determined, different from the subject and each other. A first distance of a vector distance metric between the subject and the first neighbor is less than a distance between the subject and any other individual of the first population. A second distance between the first neighbor and the second neighbor is less than a distance between the first neighbor and any other individual of the first population. A deviation of the subject from the first population is determined based on a ratio of the first distance divided by the second distance and presented on a display device. | 12-10-2015 |
20150356241 | METHODS AND SYSTEMS FOR DETERMINING META-GENOTYPES - In one exemplary embodiment, a computer-implemented method for determining a genetic result from a biological sample is provided. The method includes receiving nucleic acid amplification data of a biological sample, by a processor, from a biological instrument. The method further includes storing translation data, in a memory. The translation data includes a pattern of assay values associated with possible genetic results. The method further includes comparing the translation data with the nucleic acid amplification data, by the processor, to generate the genetic result of the biological sample. Moreover, the method includes displaying the genetic result, on a display, to a user. | 12-10-2015 |
20150356242 | Systems and Methods for Gene Expression Analysis - The present disclosure provides systems, methods, and a computer-readable storage medium for identifying and selecting highly relevant sets of genes (or Gene Signatures and biomarkers), which, when coupled with clinical and/or demographic data are highly predictive of potential clinical responses to a targeted therapy. It also provides systems, methods, and a computer-readable storage medium for determining the expected response to the targeted therapy when using the selected gene/biomarker set. | 12-10-2015 |
20150356262 | SYSTEMS AND METHODS FOR PROVIDING A USER ENGAGEMENT PLATFORM TO SUPPORT CLINICAL DECISIONS - Systems and methods are disclosed for providing a user engagement platform to support clinical decisions. The user engagement platform is a point of care decision support platform for inpatients in an emergency department (ED), an intensive care unit (ICU), or other medical care department or facility that services patients with critical care needs. The user engagement platform is configured to receive and process data parameters obtained from a patient electronic health record (EHR), identify abnormalities based on such data parameters, prompt a user (e.g., clinician or other healthcare professional such as a nurse) to consider conditions common in ICU or ED patients that could result in patient death and update the patient EHR based on such user input. | 12-10-2015 |
20150362448 | Signal process system and method for the same and biological resistance detection device and element - A signal process system and the method for the same and a biological resistance detection device and element used to perform corresponding signal process for sensory signal sensed by a sensor, wherein a minor AC electrical signal is injected into a biological tissue to be measured in order to sense the sensory signal of the biological tissue to be measured by means of the principle of Ohm's Law. Moreover, the sensory signal may be processed to restore a biological property of the measured biological tissue and to create an equivalent circuit parameter model representative of the biological property. | 12-17-2015 |
20150363546 | EVOLUTIONARY MODELS OF MULTIPLE SEQUENCE ALIGNMENTS TO PREDICT OFFSPRING FITNESS PRIOR TO CONCEPTION - A system, device and method for receiving multiple aligned genetic sequences obtained from genetic samples of multiple organisms of one or more different species. A measure of evolutionary variation may be computed for one or more alleles at each of one or more aligned genetic loci. The aligned genetic loci in the multiple organisms may be derived from one or more common ancestral genetic loci or may be otherwise related. The measure of evolutionary variation may be a function of variation in alleles at corresponding aligned genetic loci in the multiple aligned genetic sequences. One or more likelihoods may be computed that an allele mutation at each of the one or more genetic loci in a simulated virtual progeny will be deleterious based on the measure of evolutionary variation of alleles at the corresponding aligned genetic loci for the multiple organisms. | 12-17-2015 |
20150363558 | Method of Determining Predisposition to Endometriosis - The present invention relates to novel genetic markers associated with endometriosis and risk of developing endometriosis, and methods and materials for determining whether a human subject has endometriosis or is at risk of developing endometriosis and the use of such risk information in selectively administering a treatment that at least partially prevents or compensates for an endometriosis related symptom. | 12-17-2015 |
20150363561 | METHODS AND SYSTEMS FOR PROVIDING THE PROXIMITY OF A PROCESS REQUIREMENT METRIC TO A SYSTEM PROCESS REQUIREMENT - Methods and systems are presented for indicating the proximity of a process requirement metric to a corresponding system process requirement in a physiological monitor. Metrics are determined based on a received physiological signal, such as a PPG signal. At least one of the metrics is compared to a corresponding system process requirement, such as a threshold, which can be used to trigger a system process, such as an alarm, a recalibration, or a measurement. The proximity of the metric to the corresponding system process requirement is calculated and indicated. Indicating the proximity to a system process requirement may provide valuable information to clinicians and allow them to manually trigger system processes, such as measurements or recalibrations, when a metric is close to a system process requirement for a significant period of time. | 12-17-2015 |
20150370959 | Phased Whole Genome Genetic Risk In A Family Quartet - An embodiment of the present invention is a methodology for prioritizing variants relevant to inherited Mendelian (“single gene”) disease syndromes according to disease phenotype, gene, and variant level information. | 12-24-2015 |
20150370964 | Computer Aided Drug Resistance Calculator Calculating Drug Resistance Using Amprenavir As A Case Study - Signal Processing-based Computer-Aided Drug Resistance Calculator (CARDC) has been proposed [14]. The result of the drug resistances obtained then demonstrated very small margin. It was noted that more than one amino acids parameter is engaged in one mutation. It became necessary to further apply CARDC on studies which have information on both mutations in the target protein and the amino acids parameters involved. Amprenavir, an anti-HIV/AIDS that has been approved by FDA has been studied and information regarding mutations and amino acids parameters are available [12]. CARDC is therefore applied on these mutations and amino acids parameters presented. | 12-24-2015 |
20150371009 | DRUG IDENTIFICATION MODELS AND METHODS OF USING THE SAME TO IDENTIFY COMPOUNDS TO TREAT DISEASE - Drug identification models and methods of using the same to identify compounds to treat disease. In at least one method of the present disclosure, at least one first drug/compound which is not actively approved by a governmental regulatory entity to treat a targeted disease or condition, which was not previously approved to treat the targeted disease or condition, and which was not previously withdrawn from clinical testing in connection with the targeted disease or condition is tested within a framework configured using drug/compound data from actively approved drugs/compounds and withdrawn drugs/compounds in attempt to identify at least one candidate drug/compound to treat the targeted disease or condition. | 12-24-2015 |
20150374267 | AUTOMATIC RESET OF PHYSICAL PERFORMANCE INFORMATION - Embodiments are disclosed to automatically reset tracked physical performance information determined based on motion data generated using a sensor configured to measure motion of a user wearing a fitness monitoring device by calculating, utilizing the motion data, a reset time when a period of inactivity within each of a plurality of consecutive sampling periods exceeds a threshold time period. The fitness monitoring device may determine, utilizing the motion data stored over an extended period of time, an approximated midnight time and adjust the reset time to equal the approximated midnight time. The fitness monitoring device may generate motion data to track a number of steps achieved towards a goal, which may represent a threshold number of steps to be taken over a period of time. Embodiments also include utilizing other sensor data, such as light intensity data, to determine when a user is likely asleep. | 12-31-2015 |
20150374283 | METHOD AND DEVICE FOR MOBILE TRAINING DATA ACQUISITION AND ANALYSIS OF STRENGTH TRAINING - The invention relates to the field of mobile training data acquisition in sport, particularly in strength training, body building, fitness sports and rehabilitation, as well as the analysis of said training data. The invention involves a method and a mobile device ( | 12-31-2015 |
20150379191 | Method of identifying descendant animals by their relationship to an ancestor, or ancestors, in such a way that all descendants with a specified relationship to any choice of ancestor, or blend of ancestors, can be identified from within a collection of generational records. - This invention inspects animal breeding records to identify descendants of any chosen ancestor and annotates information about each descendant's relatedness to the chosen ancestor. This information can be compiled for multiple ancestors and thereby creates the basis for a means of discovering all of the descendants who represent any blend of ancestor elements in whatever amount of relationship to those ancestors is specified by the researcher. It is made most useful in conjunction with database records, the internet and graphical user interfaces. Bloodline and pedigree researchers can make comprehensive selection choices by utilizing the means specified herein. | 12-31-2015 |
20150379193 | METHODS AND SYSTEMS FOR INTERPRETATION AND REPORTING OF SEQUENCE-BASED GENETIC TESTS - Disclosed herein are system, method, and computer program product embodiments for aiding in the interpretation of variants observed in clinical sequencing data. An embodiment operates by receiving clinical trial enrollment criteria from a user, including but not limited to genetic targeting criteria; searching a knowledge base of patient test information received from a plurality of independent entities for patients that match the clinical trial enrollment criteria; and providing to the user search results for consented patients that match the clinical trial enrollment criteria. | 12-31-2015 |
20150379228 | Artificial General Intelligence System and Method for Medicine - A medical general intelligence computer system and computer-implemented methods analyze morpho-physiological numbers for determining a risk of an emergent disease state, determining an emergent disease state, predicting a pre-emergent disease state, determining a pre-emergent disease state, and/or predicting a risk of a pre-emergent disease state. | 12-31-2015 |
20150379238 | Wearable Imaging Device for Monitoring Food Consumption Using Gesture Recognition - This invention comprises devices and methods which use a wearable camera and gesture recognition in order to identify when a person is eating. Eating-related gestures are recognized by tracking the configuration and movement of a person's thumb, a person's index finger, a portion of food, and/or a food-transporting object (such as a fork, spoon, chop stick, drinking glass, beverage can, cup, mug, or bowl). These devices and methods can help people to better manage their food consumption, energy balance, and weight. | 12-31-2015 |
20160000373 | COMPUTING USER'S PHYSIOLOGICAL STATE RELATED TO PHYSICAL EXERCISES - A method, apparatus, and computer program for estimating user's physiological state from gait measurements carried out during a physical exercise are disclosed. The physiological state is computed from at least one of step interval variability and stride interval variability acquired from the gait measurements. | 01-07-2016 |
20160000378 | Human Health Property Monitoring System - The present invention describes a system and method for assessing, monitoring and predicting disease and/or disease progression through ongoing and longitudinal analysis of various health-related parameters. | 01-07-2016 |
20160003801 | PHOTOACOUSTIC IMAGING DEVICE AND OXYGEN SATURATION MEASUREMENT METHOD - Provided is a photoacoustic imaging device including: a light source unit which generates an ultra-broadband pulsed laser beam and outputs the ultra-broadband pulsed laser beam; a filter unit which filters narrowband pulsed laser beams having predetermined different wavelength bands from the ultra-broadband pulsed laser beam to selectively extract the narrowband pulsed laser beams and outputs the narrowband pulsed laser beams as pulsed laser beams for photoacoustic imaging; and a PA (photoacoustic) unit which receives the pulsed laser beams for photoacoustic imaging to irradiate a measurement object with the pulsed laser beams for photoacoustic imaging and receives photoacoustic signals generated from the measurement object. | 01-07-2016 |
20160003821 | Method for Identifying Altered Leukocyte Profiles - Methods of identifying altered leukocyte profiles are disclosed. In one embodiment, counts or relative percentages of leukocyte cell types are received and constitute input data points. Combinations of input data points are generated. Pairs of input data points and combinations are generated. Secondary data values are generated from the pairs. Three-dimensional plots are then constructed and selected as useful for identifying an altered leukocyte profile through pattern recognition of perpendicular data inflection, data bifurcation, non-overlapping data clusters, or combinations thereof. Such a strategy results in partially or totally non-overlapping data subsets, which are then interpreted. | 01-07-2016 |
20160003842 | GLYCOPEPTIDE IDENTIFICATION - A system including a device with at least one processor and memory storing computer-executable instructions that, when executed by the at least one processor, perform a method of identifying glycopeptides in a sample, the method including, analyzing a mass spectrum of the sample to identify at least one portion of the mass spectrum having at least one characteristic of mass spectra indicative of presence of glycopeptides, identifying the glycopeptides in the sample based on the at least one identified portion; and analyzing at least one glycopeptide of the identified glycopeptides. | 01-07-2016 |
20160004813 | METHOD AND SYSTEM FOR MODEL-BASED TRACKING OF CHANGES IN AVERAGE GLYCEMIA IN DIABETES - A method, system and computer readable medium for tracking changes in average glycemia in diabetes is based on a conceptually new approach to the retrieval of SMBG data. Using the understanding of HbA1c fluctuation as the measurable effect of the action of an underlying dynamical system, SMBG provides occasional glimpses at the state of this system and, using these measurements, the hidden underlying system trajectory can be reconstructed for individual diabetes patients. Using compartmental modeling a new two-step algorithm is provided that includes: (i) real-time estimate of HbA1c from fasting glucose readings, updated with any new incoming fasting SMBG data point(s), and (ii) initialization and calibration of the estimated HbA1c trace with daily SMBG profiles obtained periodically. The estimation of these profiles includes a factorial model capturing daily BG variability within two latent factors. | 01-07-2016 |
20160004815 | DECONSTRUCTING OVERLAPPED PEAKS IN EXPERIMENTAL DATA - To determine a peak signal corresponding to a particular part of a sample, a data signal for a cluster can be transformed into a set of localized functions. For example, the data signal can be transformed to obtain coefficients of a set of wavelets, which can span a variety of scales that define an exponential decay of the wavelet. The coefficients in a time region for which a peak signal is to be obtained can be replaced with coefficients that model the behavior of tails of other peaks. The tail model can be determined using nonlinear regression, which may need to only be performed once. An inverse transform can then provide a background signal that can be subtracted from the input data signal to provide the desired peak signal. | 01-07-2016 |
20160010138 | RAPID DETERMINATION OF MICROBIAL DROWTH AND ANTIMICROBIAL SUSEPTABILITY | 01-14-2016 |
20160011116 | Pure Spectrum Extraction From Biological Samples | 01-14-2016 |
20160011167 | METHODS AND APPARATUS TO MEASURE CONSTITUTIVE RELATIONS AND FIBER ORIENTATION OF SOFT TISSUES | 01-14-2016 |
20160011170 | BLOOD CONDITION ANALYZING DEVICE, BLOOD CONDITION ANALYZING SYSTEM, AND BLOOD CONDITION ANALYZING PROGRAM | 01-14-2016 |
20160011219 | COLLAGEN IV BINDING ASSAY FOR THE DETECTION OF COLLAGEN VII | 01-14-2016 |
20160012011 | PRECISE FREQUENCY-PATTERN ANALYSIS TO DECOMPOSE COMPLEX SYSTEMS INTO FUNCTIONALLY INVARIANT ENTITIES | 01-14-2016 |
20160012191 | SYSTEM AND METHOD FOR SPOT CHECKING SMALL OUT-OF-CONTROL CONDITIONS IN A CLINICAL DIAGNOSTIC PROCESS | 01-14-2016 |
20160012201 | DETERMINATION DEVICE, COMPUTER READABLE MEDIUM, AND MARKER FOR OBTAINING INFORMATION ON LUNG CANCER | 01-14-2016 |
20160012204 | Means and Method For Improved Glycemic Control For Diabetic Patients | 01-14-2016 |
20160015307 | CAPTURING AND MATCHING EMOTIONAL PROFILES OF USERS USING NEUROSCIENCE-BASED AUDIENCE RESPONSE MEASUREMENT TECHNIQUES - Disclosed is a system and method for determining the compatibility level of users by creating an emotional DNA profile for the user and matching the emotional DNA profile with profiles of other users. Based on the matching performed, appropriate content or product is displayed to the user or the level of compatibility aspect between individuals is determined. The emotional DNA profile is created by receiving inputs from various sensors that can measure user's physiological responses to content as various signals such as, facial expression, audio tone, biometrics, eyetracking and the like for various time slices and/or optionally sub-segments of standard probe content. Based on the emotional DNA profile created for the user, the overall personality is determined by optionally augmenting additional explicitly mentioned personality information of the user. Further, the emotional DNA profile that is created is matched with other users profile to determine the level of compatibility aspect between individuals. | 01-21-2016 |
20160018427 | METHODS AND SYSTEMS FOR TUBE INSPECTION AND LIQUID LEVEL DETECTION - Container identification data from a container inspection unit that analyzes a container containing a liquid is combined with liquid level detection raw data from a liquid level detection unit that analyzes the container containing the liquid and a liquid level detection result is generated. The liquid level detection result is cross-checked with additional data from the container inspection unit. The result can be used to plan a route for the container in the laboratory automation system. | 01-21-2016 |
20160019336 | EVALUATING GENETIC DISORDERS - The present invention relates to genetic analysis and evaluation utilizing copy-number variants or polymorphisms. The methods utilize array comparative genomic hybridization and PCR assays to identify the significance of copy number variations in a human, non-human animal, and plant subject or subject group. | 01-21-2016 |
20160019337 | SUBTYPING LUNG CANCERS - This disclosure concerns the identification of biomarkers that are characteristic of squamous or non squamous (e.g., adenocarcinoma, large cell carcinoma, carcinoid tumor, sarcomatoid carcinoma) subtypes of non small cell lung cancer (NSCLC), clinically useful NSCLC classifiers, kits and arrays for distinguishing squamous and nonsquamous NSCLC subtypes, bioinformatic methods for determining clinically useful classifiers, and methods of use of each of the foregoing. | 01-21-2016 |
20160019342 | Treatment selection for lung cancer patients using mass spectrum of blood-based sample - A test for predicting whether a non-small-cell lung cancer patient is more likely to benefit from an EGFR-I as compared to chemotherapy uses a computer-implemented classifier operating on a mass spectrum of a blood-based sample obtained from the patient. The classifier makes use of a training set which includes mass spectral data from blood-based samples of other cancer patients who are members of a class of patients predicted to have overall survival benefit on EGFRI-Is, e.g., those patients testing VS Good under the test described in U.S. Pat. No. 7,736,905. This class-labeled group is further subdivided into two subsets, i.e., those patients which exhibited early (class label “early”) and late (class label “late”) progression of disease after administration of the EGFR-I in treatment of cancer. | 01-21-2016 |
20160025673 | System Error Compensation Of Analyte Concentration Determinations - During analyte analysis, errors may be introduced into an analysis by both the biosensor system used to perform the analysis and by errors in the output signal measured by the measurement device of the biosensor. For a reference sample, system error may be determined through the determination of relative error. However, during an analysis of a test sample with the measurement device of the biosensor system, true relative error cannot be known. A pseudo-reference concentration determined during the analysis may be used as a substitute for true relative error. The present invention introduces the determination of a pseudo-reference concentration determined during the analysis as a substitute for the true relative error and uses an anchor parameter to compensate for the system error in the analysis-determined pseudo-reference concentration. | 01-28-2016 |
20160026753 | Systems and Methods for Analysis and Interpretation of Nucleic Acid Sequence Data - Systems and method for annotating variants within a genome can call variants from reads or receive called variants directly and associate the called variants with functional annotations and interpretive annotations. A summary report of the called variants, the associated functional annotations, and the associated interpretive annotations can be generated. | 01-28-2016 |
20160026754 | METHODS AND SYSTEMS FOR IDENTIFYING A PHYSIOLOGICAL STATE OF A TARGET CELL - Embodiments of various aspects described herein are directed to methods, systems, and kits for identifying a functional or physiological state of a target cell. The inventions described herein are based on a novel approach that combines biochemical expression measurements of a sample (e.g., gene expression data) with mapping of the measurements onto a graphical representation of a plurality of reference points (loci). Each reference point corresponds to a reference sample with a known phenotype and reflects interrelationships between multi-dimensional biochemical expression measurements of the reference samples. By locating the sample relative to reference points on the graphical representation, the physiological or functional state of the sample can be identified. The methods, systems and kits described herein can be used for various applications, including, e.g., but not limited to, determining an effect of a perturbagen on a target cell, molecule screening, and diagnosis and/or treatment of a subject. | 01-28-2016 |
20160026755 | Identifying Ancestral Relationships using a Continuous Stream of Input - Identification of inheritance-by-descent haplotype matches between individuals is described. A set of tables including word match, haplotypes and segment match tables are populated. DNA samples are received and stored. A word identification module extracts haplotype values from each sample. The word match table is indexed according to the unique combination of position and haplotype. Each column represents a different sample, and each cell indicates whether that sample includes that haplotype at that position. The haplotypes table includes the raw haplotype data for each sample. The segment match table is indexed by sample identifier, and columns represent other samples. Each cell is populated to indicate for each identified sample pair which position range(s) include matching haplotypes for both samples. The tables are persistently stored in databases of the matching system. As new sample data is received, each table is updated to include the newly received samples, and additional matching takes place. | 01-28-2016 |
20160026757 | METHOD AND APPARATUS FOR CALLING SINGLE-NUCLEOTIDE VARIATIONS AND OTHER VARIATIONS - Base calls for a target sequence may be identified relative to a reference sequence by using values from sequencing reads at locations satisfying a high-confidence condition to identify base calls at a given location not satisfying the high-confidence condition. The high-confidence condition may relate to the level of coverage by the sequencing reads at a location of the reference sequence. The quality of measurements of the sequencing reads may be incorporated into the base-call process. | 01-28-2016 |
20160026760 | Systems and Methods for the Determination of a Copy Number of a Genomic Sequence - System and methods for the determination of a copy number of a target genomic sequence; either a target gene or genomic sequence of interest, in a biological sample are described. Various methods utilize a model drawn from a probability density function (PDF) for the assignment of a copy number of a target genomic sequence in a biological sample. Additionally, the methods provide for the determination of a confidence value for a copy number assigned to a sample based on attributes of the sample data. Additionally, various embodiments of an interactive graphical user interface (GUI) may provide an end-user with ready analysis of large sets of data representing a plurality of samples. In various embodiments of an interactive GUI, an end-user may be provided with a synchronized display of tabular and graphical sample data determined by an initial analysis according to a statistical model of a PDF. Such a synchronized display may enable an end-user to readily identify sample data for a subsequent analysis based on user input. | 01-28-2016 |
20160026764 | VIRTUAL DIAGNOSTIC TEST PANEL DEVICE, SYSTEM, METHOD AND COMPUTER READABLE MEDIUM - A system virtually tests for diagnostic results in a subject, and includes databases and processors. The databases include test results, QC data, and diagnostic matrices. Each diagnostic matrix indicates one of the diagnostic results. The processors automatically apply: interpretation algorithms to generate result coordinates; and QC protocols to generate QC coordinates. The processors automatically: combine result coordinates with corresponding QC coordinates to generate a virtual test panel matrix; and when the virtual test panel matrix matches one or more of the diagnostic matrices, determine each aforesaid corresponding one of the diagnostic results which matches the virtual test panel matrix. Also disclosed are a device, method and computer readable medium. | 01-28-2016 |
20160026770 | Method of evaluating lifestyle-related disease indicator, lifestyle-related disease indicator-evaluating apparatus, lifestyle-related disease indicator-evaluating method, lifestyle-related disease indicator-evaluating program product, lifestyle-related disease indicator-evaluating system, and information communication terminal apparatus - A method of evaluating lifestyle-related disease indicator includes (i) an obtaining step of obtaining amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated and (ii) an evaluating step of evaluating a state of an indicator of lifestyle-related disease for the subject using the concentration values of the amino acids of Gly and Tyr included in the amino acid concentration data of the subject obtained at the obtaining step. | 01-28-2016 |
20160029601 | COMPUTER PRODUCT, VEGETATION ASSESSING APPARATUS, AND VEGETATION ASSESSING METHOD - A non-transitory, computer-readable recording medium stores therein a vegetation assessing program that causes a computer to execute a process including assessing whether a state of vegetation of a pasture is a state suitable for pasturing, based on temporal changes of step count measurement results obtained by a step measuring device attached to a livestock animal pastured in the pasture; and outputting an obtained assessment result. | 02-04-2016 |
20160029942 | DEVICES, SYSTEMS, AND METHODS FOR OBTAINING AND ANALYZING URINE FLOW RATE DATA USING ACOUSTICS AND SOFTWARE - Flow rate measurement devices and systems for accurate urine analysis to determine benign prostatic hyperplasia (BPH) or urethral stricture disease (USD) generally comprise a recording unit, an analysis unit, and a transmission unit. The recording unit includes device hardware and/or software configured to record data related to urinary flow rate. The analysis unit includes device hardware and/or software configured to assess, analyze, evaluate, or otherwise appraise the recorded data. The transmission unit includes device hardware and/or software configured to transmit the recorded and analyzed data. | 02-04-2016 |
20160033387 | Enhancing Flow Cytometry Discrimination with Geometric Transformation - In flow cytometry, particles ( | 02-04-2016 |
20160034634 | MULTIMODE SENSOR DEVICES - The disclosure provides BMDs that have multiple device modes depending on operational conditions of the devices, e.g., motion intensity, device placement, and/or activity type. The device modes are associated with various data processing algorithms. In some embodiments, the BMD is implemented as a wrist-worn or arm-worn device. In some embodiments, methods for tracking physiological metrics using the BMDs are provided. In some embodiments, the process or the BMD applies a time domain analysis on data provided by a sensor of the BMD when the data has a high signal (e.g., high signal-to-noise ratio), and applies a frequency domain analysis on the data when the data has a low signal, which contributes to improved accuracy and speed of biometric data. | 02-04-2016 |
20160034635 | EVOLUTIONARY MODELS OF MULTIPLE SEQUENCE ALIGNMENTS TO PREDICT OFFSPRING FITNESS PRIOR TO CONCEPTION - A system, device and method for receiving multiple aligned genetic sequences obtained from genetic samples of multiple organisms of one or more different species. A measure of evolutionary variation may be computed for one or more alleles at each of one or more aligned genetic loci. The aligned genetic loci in the multiple organisms may be derived from one or more common ancestral genetic loci or may be otherwise related. The measure of evolutionary variation may be a function of variation in alleles at corresponding aligned genetic loci in the multiple aligned genetic sequences. One or more likelihoods may be computed that an allele mutation at each of the one or more genetic loci in a simulated virtual progeny will be deleterious based on the measure of evolutionary variation of alleles at the corresponding aligned genetic loci for the multiple organisms. | 02-04-2016 |
20160034638 | System and Method for Detecting Population Variation from Nucleic Acid Sequencing Data - The present invention relates to a method of identifying genetic variants within a population of sequences. The method includes the steps of aligning a set of sequence data reads to reference sequences, dividing reference sequences into multiple tracks of overlapping regions of analysis (ROAs), partitioning each read into a ROA, identifying a plurality of sequence patterns in the reads, setting a sequence pattern frequency threshold value, eliminating any sequence pattern that has a value below the frequency threshold value forming a plurality of dictionaries from the sequence patterns having a value above the frequency threshold value, and cross-validating sequence patterns via partial sequence assembly. The method may optionally include amending the reference sequences used in iterative re-alignment of sequence data. | 02-04-2016 |
20160034659 | ANALYZING DATA FROM A SENSOR-ENABLED DEVICE - An approach for analyzing data collected by a sensor-enabled device over a network is provided. Specifically, in a typical embodiment, a set of usage data will be received from a device over a network. The set of usage data may be collected via at least one sensor integrated with the device, and the set of usage data may pertain to use of the device by a user. Regardless, the set of usage data will be compared to a set of diagnostic information stored in at least one computer storage device. The set of diagnostic information typically pertains to a condition (e.g., medical) treated by use of the device (e.g., dental, cardiac, renal, etc.). Based on the comparison, at least one determination (e.g., diagnosis, treatment plan, level of compliance with applicable standards, etc.) will be made and a set of reports will be generated based thereon. | 02-04-2016 |
20160038099 | MAGNETIC RESONANCE IMAGING APPARATUS, MEDICAL INFORMATION PROCESSING DEVICE, AND PATIENT INFORMATION DISPLAY METHOD - In one embodiment, a magnetic resonance imaging apparatus includes an input device by which patient information including at least height and weight is inputted; a display; and processing circuitry configured to calculate a BMI (Body Mass Index) indicated by weight (kg)/{height (m)} | 02-11-2016 |
20160040222 | Systems And Methods For Baseline Correction Using Non-Linear Normalization - Systems and methods are provided for calibrating emission data or other information signals collected during a polymerase chain reaction (PCR), amplification reaction, assay, process, or other reaction. Calibration of multiple detectable materials can be achieved during a single cycle or run, or during a plurality of runs of the reaction. A reading from every well, container, or other support region of a sample support does not have to be taken. Interpolation can be used to determine values for emission data or other information signals that were not taken, or are unknown, using detected emission data, or other detected information signals. By calibrating the detected emission data and the interpolated data, a more accurate reading of emission data or information signal can be obtained. | 02-11-2016 |
20160041146 | METHODS OF NORMALIZING THE RATIO OF MEASURED PARENT AND METABOLITE DRUG CONCENTRATIONS IN FLUIDS AND TESTING FOR NON-COMPLIANCE - Methods for monitoring subject compliance with a prescribed treatment regimen are disclosed. In an embodiment, the method comprises measuring a drug and a metabolite level in fluid of a subject and transforming the ratio of the measured drug levels and comparing the subsequent Drug Ratio with a likewise transformed Data Set of drug/metabolite ratios. Using the transformed ratio of parent drug to metabolite eliminates the need for further adjustments using patient specific parameters and other transforming/normalizing quantities. | 02-11-2016 |
20160042121 | COMPOSITIONS AND METHODS RELATED TO OBSTRUCTIVE SLEEP APNEA - The technology concerns methods and compositions for diagnosing obstructive sleep apnea, a common condition observed in children. In certain embodiments, there are methods and compositions relating to the use of novel biomarkers to diagnose obstructive sleep apnea. | 02-11-2016 |
20160042658 | SYSTEM AND METHOD TO PROVIDE CAREER COUNSELING AND MANAGEMENT USING BIOFEEDBACK - An apparatus and method for measuring a person's biometric data as well as associated data and for using that data to determine the person's talents and well-being state, as well as predicting an optimal career path for the person. Biometric data is measured using a sensor, a memory configured to store the biometric signals, a database configured to store and retrieve profiles, and a processor configured to compare biometric data as well as associated data with anonymous profiles stored in the database and create a profile for the person. | 02-11-2016 |
20160043819 | SYSTEM AND METHOD FOR PREDICTING AUDIENCE RESPONSES TO CONTENT FROM ELECTRO-DERMAL ACTIVITY SIGNALS - A method for decomposing Electro-Derma Activity signals from a user to infer response to content commences by first high-pass filtering the raw EDA signals collected from a user to reduce the influence of tonic signals. The high-pass filtered EDA signals are then fitted to a dictionary of feasible skin conductance response signals. | 02-11-2016 |
20160045159 | Calculating Pace and Energy Expenditure from Athletic Movement Attributes - Systems and methods configured to process motion data associated with a user. The systems and methods are configured to receive motion data from a sensor, calculate motion attributes from the data, and classify the motion data using one or more mathematical models. Attributes may be calculated without classifying the motion data into an activity type (such as walking, running, swimming, or any specific or general activity). Attributes may be compared to activity models comprising motion data from several individuals, which may not include the user. Motion data within the models and attributes of the user may be independent of any activity type. Attributes may be compared to select an energy expenditure model from one or more energy expenditure models, which may be selected as a best-match to the one or more motion attributes. An energy expenditure associated with the motion of the user may then be calculated. | 02-18-2016 |
20160048632 | GENE EXPRESSION PROFILE ALGORITHM FOR CALCULATING A RECURRENCE SCORE FOR A PATIENT WITH KIDNEY CANCER - The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence. | 02-18-2016 |
20160048658 | RESEARCH PERFORMANCE FRAMEWORK - There is provided a research framework system. For example, in some implementations there is provided a sleep prediction system for pilots including a first data structure storing collected research data related to pilot sleep patterns, a second data structure storing data related to a flight schedule associated with a pilot, and a sleep prediction module configured to access the data stored in the first and second data structures and calculate, by one or more processors using the data stored in the first data structure, a likelihood that the pilot associated with the flight schedule stored in the second data structure is sleeping at a given time. | 02-18-2016 |
20160048659 | METHOD AND TOOLS FOR PREDICTING A PAIN RESPONSE IN A SUBJECT SUFFERING FROM CANCER-INDUCED BONE PAIN - A method is described for predicting a pain response in a subject suffering from cancer-induced bone pain (CIBP). Data is collected from the subject by querying the subject on personality and/or health traits, and/or performing one or more social learning and/or (bio)physical tests by or on the subject. The data is used in a set of mathematical models to attribute one or more Scoring Factors to the subject. The Scoring Factor is a measure of the propensity of the subject to raise a response to a pain stimulus or a treatment strategy; and/or a measure of the intensity of the response of the subject. | 02-18-2016 |
20160051152 | METHOD FOR ESTIMATING BLOOD LOSS FROM FLUIDS COLLECTED DURING SURGERY - The invention relates to a method for estimating blood loss from a sample of fluid collected during surgery. The method includes utilizing spectrophotometric analysis to determine a hemoglobin proportion within the sample, and estimating a patient's total blood loss based upon the analysis and known proportions of hemoglobin mass to blood volume. | 02-25-2016 |
20160055292 | METHODS FOR QUANTITATIVE ANALYSIS OF CELL SPATIAL TRAJECTORIES - Aspects of the present disclosure generally relate to methods for analyzing spatial trajectories of cells by identifying metrics corresponding to cell spatial properties and analyzing the metrics over time. | 02-25-2016 |
20160055294 | METHOD AND APPARATUS FOR DETERMINING TRANSCRIPTION FACTOR FOR BIOLOGICAL PROCESS - A method and an apparatus for determining a transcription factor for a biological process are provided. The method of determining a transcription factor involves obtaining N items of expression data related to gene information, selecting M items of expression data based on similarities of the N items of expression data, and forming the selected M items of expression data as a first group using a processor, comparing the expression data of the first group to expression data of a plurality of transcription factors, and identifying at least one transcription factor having a relatively high similarity to the first group, among the transcription factors, in which M is a natural number less than or equal to N. | 02-25-2016 |
20160058332 | LOCAL MODEL FOR CALORIMETRY - In one aspect, the present disclosure relates to a method including obtaining, by a fitness tracking device configured to be worn by a user, a plurality of physical characteristics of the user, wherein the plurality of physical characteristics includes a first age and a sex of the user; mapping, by the fitness tracking device, each physical characteristic of the user to a corresponding index, wherein the first age of the user is mapped to a first age index of a first age range of a plurality of age ranges, and wherein the sex of the user is mapped to a first sex index; selecting, from a memory of the fitness tracking device, a first calorimetry model of a plurality of calorimetry models, wherein the first calorimetry model is associated with each corresponding index, including the first age index and the first sex index of the user; and estimating, by the fitness tracking device, an energy expenditure rate using the first calorimetry model, wherein the fitness tracking device can include constrained resources for at least one of battery power, processor speed, and memory capacity. | 03-03-2016 |
20160058333 | METHOD TO ESTIMATE PHYSICAL ACTIVITY RATING FROM PEDOMETER DATA - In one aspect, the present disclosure relates to a method including obtaining, by a fitness tracking device, an average step count of a user of the fitness tracking device; mapping, by the fitness tracking device, the average step count to a first corresponding physical activity level of a plurality of physical activity levels; storing, in a memory of the fitness tracking device, the first corresponding physical activity level; estimating, by the fitness tracking device, an aerobic capacity of the user using the first corresponding physical activity level of the user; and estimating, by the fitness tracking device, an energy expenditure rate of the user using the aerobic capacity of the user. | 03-03-2016 |
20160058334 | ACTIVITY STATUS INFORMATION COMPUTATION SYSTEM - An activity status information computation system includes: a first information acquisition unit which acquires measured biometric information measured about a user; a second information acquisition unit which acquires personal biometric setting information set as personal information of the user; and a processing unit which carries out computation processing of activity status information of the user on the basis of the measured biometric information and the personal biometric setting information. when there is an alteration request about the personal biometric setting information, the processing unit carries out decision processing about a timing of reflecting the alteration of the personal biometric setting information on the computation processing of the activity status information, or decision processing about whether to reflect the alteration or not, according to an attribute of the personal biometric setting information. | 03-03-2016 |
20160061731 | ANALYSIS METHOD AND SYSTEM FOR ANALYZING A NUCLEIC ACID AMPLIFICATION REACTION - An analysis method is provided aimed at improving the linearity (precision and/or accuracy) of a quantification by a real-time nucleic acid amplification reaction RNR such as a polymerase chain reaction PCR over a wide range of analyte concentrations and/or limiting the effects of the presence of interfering substances by way of determining a quantification cycle number (Cq) of the RNR as the cycle number corresponding to an intersection of the growth curve with a combined threshold function (CTF) over the RNR cycle range comprising at least two different threshold levels, the quantification cycle number (Cq) being indicative of a quantitative and/or qualitative analysis result of a growth curve, the growth curve being indicative of the intensity of the fluorescence emission of an analyte for each amplification reaction cycle of the RNR over a RNR cycle range. | 03-03-2016 |
20160063180 | METHOD AND APPARATUS FOR IDENTIFICATION OF BIOMOLECULES - The present disclosure presents methods, systems, and devices for dentifying new molecules directly from biological sequence information, with at least one of a desired bioactivity profile, functional attribute, biochemical reactivity, biological impact, pharmacological characteristic or therapeutic effect. The present disclosure further includes analyzing, at the processor, data features of biological sequence information and other data sources, including a feature-definition set by processing, using one or more bioinformatic techniques, computational algorithms, or methods of statistical machine learning, data sources relating to biological or chemical molecules, including biomolecules, including but not limited to peptides, having desired physical or chemical characteristics, bioactivities, functional attributes, biological impacts, pharmacologic properties or therapeutic effects. | 03-03-2016 |
20160063181 | Interface Method And System For Genetic Analysis Data - Aspects of the present invention describe a method and apparatus for viewing and interfacing with gene expression on a computer device. A computer based device interfaces with gene the expression data by representing a plate having one or more wells and their contents with a matrix of elements addressable along at least two-dimensions. Each of the elements in the matrix are processed and then distinguished based upon their passing and failing one or more metrics for gene expression data. The interface displays those values associated with the distinguished elements in the matrix using colors, shapes and symbols. Depending on the results, some of the elements in the matrix may be flagged and then filtered from the data set. Remaining gene expression values not filtered from the matrix of elements are displayed and processed further. | 03-03-2016 |
20160066878 | INFORMATION PROCESSING APPARATUS FOR CALCULATING INDEX FOR SUPPORTING DIAGNOSIS OF SUBJECT - An object is to more accurately compare diagnosis indexes with each other, which are calculated from data obtained in different environments with a cardiac-function diagnostic medicine. A conversion function calculation unit acquires a first phantom Heart/Mediastinum ratio (H/M ratio) and a second phantom H/M ratio based on a phantom, the first phantom H/M ratio that is an H/M ratio of the phantom in the first imaging environment being acquired by performing, based on phantom data that is data of a first phantom image obtained by imaging the phantom in the first imaging environment and digital phantom data that is data of a digital phantom including a cardiac ROI and a mediastinum ROI, positioning of the digital phantom on the first phantom image, and by calculating based on the phantom data of the first phantom image to which the cardiac ROI and the mediastinum ROI are set; and obtains a conversion function based on the first phantom H/M ratio and the second phantom H/M ratio. | 03-10-2016 |
20160069847 | Systems And Methods To Determine Body Drug Concentration From An Oral Fluid - Oral fluid for drug testing has several advantages over other specimens: (1) It may be collected noninvasively and under direct supervision; (2) its drug concentration reflects blood-drug concentrations; and (3) it can be processed by conventional drug screening and confirmation methods. This technology provides a system that measures the quantity of a drug (without needing a priori knowledge of the drug) in an oral fluid specimen and translates this level to a blood plasma drug concentration. The method first measures the concentration of a drug in an oral fluid sample. Next, a processor calculates the blood plasma concentration from the measured oral fluid drug concentration. Finally, this blood plasma drug level is utilized to calculate a total body drug concentration. | 03-10-2016 |
20160070675 | CALIBRATION METHOD FOR THE PROSPECTIVE CALIBRATION OF MEASURING EQUIPMENT - A method for operating measuring equipment for detecting at least one analyte in a bodily fluid by means of at least one continuously measuring blood glucose sensor. At least one calibration method is carried out for the prospective calibration of the measuring equipment. At least three calibration points are detected in the calibration method, wherein each calibration point comprises at least one measurement signal from the measuring equipment and at least one reference value of an associated reference measurement. A plurality of possible slopes are established between the calibration points. At least one robust estimation method, more particularly using a formation of at least one median, is used to determine at least one probable slope from the plurality of possible slopes. Furthermore, at least one measurement is carried out. During the measurement and using the probable slope, a concentration of the analyte in the bodily fluid is deduced from at least one measurement signal from the measuring equipment and the probable slope. | 03-10-2016 |
20160070852 | PROGNOSIS PREDICTION FOR ACUTE MYELOID LEUKEMIA BY A 3-MICRORNA SCORING METHOD - The present invention relates to a scoring method for predicting the survival of a de novo AML patient based on the expression level of microRNAs mir-9, mir-155 and mir-203 in the patient. Patients with higher scores are associated with shorter overall survival. This scoring method is simple, powerful, and widely applicable for risk stratification of AML patients. | 03-10-2016 |
20160070854 | ALIGNING AND CLUSTERING SEQUENCE PATTERNS TO REVEAL CLASSIFICATORY FUNCTIONALITY OF SEQUENCES - A system and method of discovering sequence patterns with variations is provided. The method includes: accessing or acquiring a data set including a family of sequences or related families of sequences; a) applying a pattern discovery process to the sequences; b) grouping and aligning the similar patterns that may have different lengths into one or more Aligned Pattern Clusters; c) discovering the co-occurrence relation between Aligned Patterns and/or Aligned Pattern Clusters to reveal the distal function between segments represented by the aligned Pattern Clusters and d) breaking down an Aligned Pattern Cluster into sub-clusters with stable cluster configuration that reveals sub-clusters with distinct and shared characteristic among sub-family of the sequences. | 03-10-2016 |
20160070855 | Systems And Methods For Determination Of Provenance - Systems and methods for genomic analysis are contemplated in which idiosyncratic markers or marker constellations are employed to characterize and compare genomic sequences. In especially preferred aspects, the idiosyncratic markers are predetermined SNPs and a marker profile is used in a sample record to so allow cross reference to other marker profiles of other sequences. | 03-10-2016 |
20160070856 | VARIANT-CALLING ON DATA FROM AMPLICON-BASED SEQUENCING METHODS - The invention provides systems and methods for calling variants in data from amplicon-based sequencing methods by aligning and assembling reads, associating the reads with their source amplicons, treating each amplicon as a separate sample or file, calling variants on the reads. A portion of each read is aligned to the primer binding site of the associated amplicons. Variants called at sites in the mapped portions of each read are discarded. The remaining variant calls are merged, to provide a set of variant calls across the original target region. | 03-10-2016 |
20160070858 | VISUALIZING GENOMIC DATA - Clinical decision support visualization methods that use information, pathways, or inferred regulatory networks for the entire genome, transcriptome, exome, or methylome to highlight genomic activity to further the understanding of the clinical condition of a patient or to contrast different patient groups. | 03-10-2016 |
20160078169 | METHOD OF AND APPARATUS FOR PROVIDING INFORMATION ON A GENOMIC SEQUENCE BASED PERSONAL MARKER - The present disclosure provides a method for providing information about a gene sequence-based personal marker. The method includes: obtaining base sequence-related information from a target sample; performing a quality control of a base sequence corresponding to the base sequence-related information obtained from the target sample; comparing the base sequence, for which the quality control is performed, with a reference sequence; extracting a personal identification genetic variation marker from a result of the sequence comparison; evaluating optimality of the extracted personal identification genetic variation marker; and outputting a sequence corresponding to a personal identification genetic variation marker having the evaluated optimality which is higher than a predetermined level. | 03-17-2016 |
20160078171 | Method Utilizing Repeat PSA Screening for Diagnosis of Virulent Prostate Cancer - A method for detecting aggressive prostate cancer is described, for instance for use in determination of the need for biopsy based. Disclosed methods recognize the difference in PSA rate of change for men in different prostate health states and having different risk profiles so as to provide a route for earlier detection of aggressive prostate cancer, for example in asymptomatic men. | 03-17-2016 |
20160078172 | SYSTEMS AND METHODS FOR DETERMINING THE PROBABILITY OF A PREGNANCY AT A SELECTED POINT IN TIME - The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome. | 03-17-2016 |
20160078182 | Using Toxicity Level in Treatment Recommendations by Question Answering Systems - Mechanisms are provided for outputting a treatment recommendation for a medical malady. The mechanisms receive an input specifying a medical malady of a specified patient and determine one or more constituent agents of a potential treatment for the specified medical malady of the specified patient. The mechanisms retrieve a treatment toxicity profile corresponding to the medical malady. In addition, the mechanisms calculate a treatment toxicity score for the potential treatment based on a comparison of patient medical attributes of the specified patient to toxicity criteria associated with the one or more constituent agents identified in the treatment toxicity profile. The mechanisms then output a treatment recommendation based on the treatment toxicity score. | 03-17-2016 |
20160078194 | SYSTEM AND METHOD FOR MEDICAL TESTING - A method of analyzing a medical condition includes creating a wireless communication link between a base unit and a test device at a first location, initiating a test protocol utilizing the test device at the first location, remotely controlling the test protocol with the base unit, generating test data using the test device according to the test protocol, and transmitting the test data to a second location at a different site than the first location. The test data is indicative of performance of a physiological function. | 03-17-2016 |
20160084778 | METHOD FOR EXANIMATION OF ELEMENT IN LIVING BODY - The nutritionally and/or medically significant measured value on mineral elements contained in the body of a test subject can be detected by a hair test. The signal ratio P | 03-24-2016 |
20160085908 | Melt Curve Analysis - A method of high resolution melting curve analysis for characterizing nucleic acid molecules such as PCR products having a distinct Tm using fluorescence is provided. The technique comprises modeling the raw melting curve data as a sum of at least two signal components, the first signal component representing the light intensity emitted by unbound/free fluorophores and the one or more second signal components representing the combined light intensity emitted by fluorophores bound to double stranded DNA. Numerical analysis is used to determine the values of the different components contributing to the total signal such that the model matches the raw fluorescence data as closely as possible. The method enables an improved resolution of mixtures of target nucleic acids even at non-saturating dye concentrations because it takes into account the effect of redistribution of intercalating dye from low-temperature duplexes to duplexes that melt at higher temperatures. | 03-24-2016 |
20160085909 | Methods of Selection, Reporting and Analysis of Genetic Markers Using Broad-Based Genetic Profiling Applications - Disclosed is a method for determining whether an individual has an enhanced, diminished, or average probability of exhibiting one or more phenotypic attributes and related methods of selecting a set of genetic markers; for providing relevant genetic information to an individual; of evaluating the probability that progeny of two individuals of the opposite sex will exhibit one or more phenotypic attributes; and for determining the genomic ethnicity of an individual. | 03-24-2016 |
20160085910 | METHODS AND SYSTEMS FOR ANALYZING NUCLEIC ACID SEQUENCING DATA - Method includes receiving sequencing data including a plurality of sample reads that have corresponding sequences of nucleotides and assigning the sample reads to designated loci. The method also includes analyzing the assigned reads for each designated locus to identify corresponding regions-of-interest (ROIs) within the assigned reads. Each of the ROIs has one or more series of repeat motifs. The method also includes sorting the assigned reads based on the sequences of the ROIs such that the ROIs with different sequences are assigned as different potential alleles. The method also includes analyzing, for designated loci having multiple potential alleles, the sequences of the potential alleles to determine whether a first allele of the potential alleles is suspected stutter product of a second allele of the potential alleles. | 03-24-2016 |
20160085912 | SYSTEMS, APPARATUS, AND METHODS FOR GENERATING AND ANALYZING RESISTOME PROFILES - Systems, apparatus, and methods are disclosed for generating a resistome profile for a subject, monitoring an infection state of one or more subjects, and/or identifying a potential infection outbreak at a facility, for example, by obtaining first data representative of at least one measure of antibiotic resistance of an organism from a first sample, identifying the organism, determining at least one of an antibiotic susceptibility phenotype, an identity of an antibiotic resistance gene, and an antibiotic to which the organism is non-susceptible, generating and comparing a first pattern to at least one known pattern to determine and generate a profile uniqueness identifier indicating a degree of similarity above a threshold between the first pattern and the at least one known pattern. | 03-24-2016 |
20160085918 | MEDICAL ASSISTANCE DEVICE, OPERATION METHOD AND OPERATION PROGRAM FOR MEDICAL ASSISTANCE DEVICE, AND MEDICAL ASSISTANCE SYSTEM - There are provided a medical assistance device, an operation method of a medical assistance device, a non-transitory computer-readable recording medium, and a medical assistance system capable of improving work efficiency by reducing the burden on a user. When a request receiving unit has not received an input of a designated data range or when there is a difference between the designated data range and a first recommended data range, an automatic data range setting unit reads a second recommended data range of the latest event from a second recommended data range list. The medical data acquisition unit extracts medical data corresponding to the second recommended data range from the medical data in the entire course of treatment for the patient. The program control unit executes a diagnostic assistance program by giving medical data corresponding to the second recommended data range as input data, and outputs diagnostic assistance information. | 03-24-2016 |
20160085932 | MEDICAL SYSTEM - A medical system includes: a transmitter which is configured to acquire biological information of a patient, and which is configured to transmit the biological information through an inherent channel; a setting terminal which is configured to recognize identification information for identifying a patient, which is configured to acquire the channel from the transmitter, and which is configured to transmit association information in which the identification information is associated with the channel; and a receiver which, by using the association information transmitted from the setting terminal, is configured to register the identification information and the channel in association with each other. | 03-24-2016 |
20160085939 | METHOD OF DETERMINING DOSE OF ERYTHROPOIESIS-STIMULATING AGENT - A method of determining an ESA dose, which allows a hemoglobin concentration in the blood to be stably maintained at a target value, and which can decrease a range of fluctuation of the hemoglobin concentration with respect to the target value. The method comprises the steps of: setting the target value of the hemoglobin concentration in the blood; calculating a target value of a hemoglobin production rate which allows the hemoglobin concentration to reach the target value; calculating a serum ESA concentration which allows the hemoglobin production rate to reach the target value, from a relationship between the hemoglobin production rate and the ESA concentration; and calculating an amount of administration of an ESA which gives the serum ESA concentration, from a relationship between the ESA concentration and the amount of administration of the ESA, to determine an ESA dose which allows the hemoglobin concentration to reach the target value. | 03-24-2016 |
20160086106 | SYSTEMS AND METHODS FOR GENERATING AUTOMATED SOFTWARE WORKFLOW FOR BIOLOGICAL TESTING - The workflow application integrates with a research software application associated with a laboratory instrument to provide a user with step-by-step instructions on how to follow the workflow steps of a laboratory experiment. The instructions are dynamically tailored, according to the nature of the workflow, the samples being experimented upon and/or the operating states of the instrument and/or the research software application. The workflow application significantly reduces the learning curve to operate sophisticated laboratory instruments. In a genetic testing instrument the workflow application can prescribe the need for control samples and can optimize the layout of samples within the instrument's sample receiving plate or fixture. | 03-24-2016 |
20160087603 | SIGNAL SEGMENTATION AND ANALYSIS - The present invention provides a system and method for representing quasi-periodic (“qp”) waveforms comprising, representing a plurality of limited decompositions of the qp waveform, wherein each decomposition includes a first and second amplitude value and at least one time value. In some embodiments, each of the decompositions is phase adjusted such that the arithmetic sum of the plurality of limited decompositions reconstructs the qp waveform. These decompositions are stored into a data structure having a plurality of attributes. Optionally, these attributes are used to reconstruct the qp waveform, or patterns or features of the qp wave can be determined by using various pattern-recognition techniques. Some embodiments provide a system that uses software, embedded hardware or firmware to carry out the above-described method. Some embodiments use a computer-readable medium to store the data structure and/or instructions to execute the method. | 03-24-2016 |
20160092630 | ACCURATE AND FAST MAPPING OF READS TO GENOME - Accurate and fast mapping of sequencing reads obtained from a targeted sequencing procedure can be provided. Once a target region is selected, alternate regions of the genome that are sufficiently similar to the target region can be identified. If a sequencing read is more similar to the target region than to an alternate region, then the read can be determined as aligning to the target region. The reads aligning to the target region can then be analyzed to determine whether a mutation exists in the target region. Accordingly, a sequencing read can be compared to the target region and the corresponding alternate regions, and not to the entire genome, thereby providing computational efficiency. | 03-31-2016 |
20160092631 | METHODS AND SYSTEMS FOR GENOME ANALYSIS - The present disclosure provides methods and systems for prioritizing phenotype-causing genomic variants. The methods include using variant prioritization analyses and in combination with biomedical ontologies using a sophisticated re-ranking methodology to re-rank these variants based on phenotype information. The methods can be useful in any genomics study and diagnostics; for example, rare and common disease gene discovery, tumor growth mutation detection, drug responder studies, metabolic studies, personalized medicine, agricultural analysis, and centennial analysis. | 03-31-2016 |
20160095539 | SMART BAND, BODY BALANCE MEASURING METHOD OF THE SMART BAND AND COMPUTER-READABLE RECORDING MEDIUM COMPRISING PROGRAM FOR PERFORMING THE SAME - Provided are a smart band, a body balance measuring method of the smart band, and a computer-readable recording medium including a program for performing the same. The smart band includes: a memory that stores a first balance factor of any one of user's left and right arms; a motion sensor that creates motion data by detecting a motion of the other one of the user's left and right arms; and a control unit that extracts a second balance factor of the other one of the user's left and right arms on the basis of the created motion data, calculates an asymmetry index, using the first and second balance factors, and calculates a final score on the basis of the asymmetry index. | 04-07-2016 |
20160097712 | SIGNAL DETECTION METHOD, CALIBRATION CURVE CREATION METHOD, QUANTIFICATION METHOD, SIGNAL DETECTION DEVICE, MEASURING DEVICE, AND GLUCOSE CONCENTRATION MEASURING DEVICE - A signal detection method includes acquiring a measurement signal including a first signal, which is a signal of a target component, and a second signal, which is a signal of an interference component; and performing an orthogonal operation for adjusting the measurement signal such that the measurement signal is orthogonal to the second signal. | 04-07-2016 |
20160097760 | METHOD AND APPARATUS FOR CHARACTERISTIC MONITORING IN CONJUNCTION WITH A MODE OF CONTINUOUSLY MEASURED BLOOD GLUCOSE VALUES AND COMPUTER PROGRAM PRODUCT - A method for characteristic monitoring in conjunction with a mode of continuously measured blood glucose values, in a monitor apparatus provided with a processor, a memory, a data interface, an input device, and a signaling device, the method comprising: providing a first set of event specific characteristics assigned to a first event, the first set of event specific characteristics being different from a second set of event specific characteristics assigned to a second event which is different from the first event, receiving blood glucose value data performing a safety check by comparing the first set of event specific characteristics to present characteristics derived from the blood glucose value data and/or the characteristic values, generating a warning signal or generating a safety signal, and outputting an output signal. A monitor apparatus is also disclosed. | 04-07-2016 |
20160098516 | METHODS AND SYSTEMS FOR DETECTION OF A GENETIC MUTATION - Methods and systems for the detection of genetic mutations from a tissue sample (e.g., a preserved tissue sample) are provided. The method includes the steps of a) extracting a nucleic acid from a tissue or biological sample; b) preparing a targeted nucleic acid amplicon library from the extracted nucleic acid; c) sequencing the targeted nucleic acid amplicon library to produce tissue sample target nucleic acid sequence data; and d) analyzing the sample target nucleic acid sequence data to determine whether it contains a mutation (e.g., a mutation associated with a risk for a particular disease). The methods described herein advantageously can be performed in less than 36 hours. | 04-07-2016 |
20160098519 | SYSTEMS AND METHODS FOR SCALABLE UNSUPERVISED MULTISOURCE ANALYSIS - Systems and methods for identifying genetic variations in a disease and diagnosing a patient with a mental illness, or a generic variant of same. The systems and methods use genomics and phenomics in a computer-implemented methods to identify biclusters in phenomic and genomic data, discover relationships among the biclusters, organize the relations into partitions, rank the predictive utility of features, and map the disease risk function. This can in turn be used to diagnose a patient in a person-centered fashion. | 04-07-2016 |
20160103953 | BIOLOGICAL SEQUENCE TANDEM REPEAT CHARACTERIZATION - Short fixed length source sub-sequences are extracted from a collection of source sequences derived from a sample for which the biological signature is to be determined. The extracted short fixed length source sub-sequences are compiled to determine the frequency of each within the collection. Overlaps between the short fixed length source sub-sequences are used to find a chain of overlaps from one or more sub-sequences equivalent to a pre-flanking reference marker sequence to one or more sub-sequences equivalent to a post-flanking reference marker sequence, wherein the reference marker sequences flank a region containing a repetitive sequence region. In response to the chain containing multiple instances of the one or more short fixed length source sub-sequences, thereby defining a cycle, the sequences from the collection derived from the sample are examined to find one or more sequences that span the cycle, and at least one of: (i) the lengths of the spanning sequences are used to determine the length of the cycle and; (ii) the number of repeat motif copies within each spanning sequence are counted. | 04-14-2016 |
20160103954 | BIOLOGICAL SEQUENCE VARIANT CHARACTERIZATION - Short fixed length sub-sequences, defined as reference sub-sequences, are extracted from a collection of reference sequences, and an index is constructed showing which short fixed length reference sub-sequence occurs in which reference sequences. Short fixed length sub-sequences, the same length as the reference sub-sequences and defined as source sub-sequences, are extracted from a collection of source sequences derived from a sample for which the signature is to be determined, and the short fixed length source sub-sequences are compiled to determine the frequency of each within the collection. The presence or absence of source sub-sequences in combination with the index is used to infer the presence or absence of reference sequences from the reference collection. | 04-14-2016 |
20160103955 | BIOLOGICAL SEQUENCE TANDEM REPEAT CHARACTERIZATION - Short fixed length source sub-sequences are extracted from a collection of source sequences derived from a sample for which the biological signature is to be determined. The extracted short fixed length source sub-sequences are compiled to determine the frequency of each within the collection. Overlaps between the short fixed length source sub-sequences are used to find a chain of overlaps from one or more sub-sequences equivalent to a pre-flanking reference marker sequence to one or more sub-sequences equivalent to a post-flanking reference marker sequence, wherein the reference marker sequences flank a region containing a repetitive sequence region. In response to the chain containing multiple instances of the one or more short fixed length source sub-sequences, thereby defining a cycle, the sequences from the collection derived from the sample are examined to find one or more sequences that span the cycle, and at least one of: (i) the lengths of the spanning sequences are used to determine the length of the cycle and; (ii) the number of repeat motif copies within each spanning sequence are counted. | 04-14-2016 |
20160103956 | BIOLOGICAL SEQUENCE VARIANT CHARACTERIZATION - Short fixed length sub-sequences, defined as reference sub-sequences, are extracted from a collection of reference sequences, and an index is constructed showing which short fixed length reference sub-sequence occurs in which reference sequences. Short fixed length sub-sequences, the same length as the reference sub-sequences and defined as source sub-sequences, are extracted from a collection of source sequences derived from a sample for which the signature is to be determined, and the short fixed length source sub-sequences are compiled to determine the frequency of each within the collection. The presence or absence of source sub-sequences in combination with the index is used to infer the presence or absence of reference sequences from the reference collection. | 04-14-2016 |
20160103957 | METHODS, SYSTEMS, AND COMPUTER-READABLE MEDIA FOR CALCULATING CORRECTED AMPLICON COVERAGES - Methods, systems, and computer-readable media are disclosed for calculating corrected amplicon coverages. One method includes: mapping a plurality of reads of a plurality of amplicons based on amplified target regions of a sample suspected of having one or more genetic abnormalities to a reference sequence that includes one or more nucleic acid sequences corresponding to the amplified target regions; calculating amplicon coverages and total reads, wherein amplicon coverages is a number of reads mapped to an amplicon, and total reads is a number of mapped reads; and calculating corrected amplicon coverages based on the calculated amplicon coverages and calculated total reads by applying a batch effect correction. | 04-14-2016 |
20160103974 | PERSONALIZED ANTIBIOTIC DOSING PLATFORM - A personalized antibiotic dosing platform may comprise method and systems configured for: receiving infection data, wherein the infection data comprises a bacterial strain and a first bacterial load of the bacterial strain; receiving patient characteristics; receiving a prescribed drug and a prescribed dosage; receiving historic bacterial response data; receiving at least one pharmacokinetic model; applying at least one algorithm based on at least one of the following: the at least one pharmacokinetic model, and the historic bacterial response data, to compute a time interval for receiving a measurement of a second bacterial load; providing the computed time interval to a user; receiving the second bacterial load after an actual time interval; analyzing data based on at least two of the following: the first bacterial load, the second bacterial load, the actual time interval, the prescription drug, and the prescription dosage; and providing a treatment recommendation. | 04-14-2016 |
20160109355 | DATA ANALYSIS APPARATUS AND DATA ANALYSIS METHOD - The data analysis apparatus according to the invention includes an indexing unit configured to calculate indexes indicating similarity between a plurality of segments, each of which is numerical data having at least one frequency component, using a frequency spectrum containing the frequency component of the segment, and a map creating unit configured to plot the segment on a map based on indexes. | 04-21-2016 |
20160110494 | MEDICAL PROGNOSIS AND PREDICTION OF TREATMENT RESPONSE USING MULTIPLE CELLULAR SIGNALLING PATHWAY ACTIVITIES - The present application relates to a method for determining a risk score that indicates a risk that a clinical event will occur within a certain period of time. The risk score is based at least in part on a combination of inferred activities of two or more cellular signaling pathways in a tissue and/or cells and/or a body fluid of a subject. The cellular signaling pathways comprise a Wnt pathway, an ER pathway, an HH pathway, and/or an AR pathway. The risk score is defined such that the indicated risk that the clinical event will occur within the certain period of time decreases with an increasing P | 04-21-2016 |
20160110496 | Methods for Classifying Samples Based on Network Modularity - Methods for classifying samples are based on alterations in network modularity. The methods are useful for the diagnosis, prognosis and monitoring of a biological state such as a disease state. In certain embodiments, methods for diagnosing disease or evaluating the prognosis of disease or identification of a disease state are computer-implemented. | 04-21-2016 |
20160110498 | METHODS AND SYSTEMS FOR ALIGNING REPETITIVE DNA ELEMENTS - Presented are methods and systems for aligning repetitive DNA elements. The methods and systems use the conserved flanks of repetitive polymorphic loci to effectively determine the length and sequence of the repetitive DNA element. | 04-21-2016 |
20160117442 | System for the Quantification of System-Wide Dynamics in Complex Networks - A device, method and system are provided for diagnosing a disease using a gene expression reader to analyze biological samples and output gene expression values to calculate a scaling factor using a computer by counting a number of link counts C | 04-28-2016 |
20160117466 | SYSTEM AND METHOD FOR RISK MANAGEMENT - This disclosure relates generally to methods and systems adapted for risk management. The system includes a processor and an analytics module. The analytics module is configured to receive, at the processor, a first result associated with a first behavior outcome based on first information related to an evaluee, second information related to a set of one or more people, and third information related to the evaluee different from the first information. The analytics module is configured to execute instructions, by the processor, to perform analytics to determine a second result associated with a second behavior outcome of the evaluee relative to the set of one or more people, based on at least the third information. | 04-28-2016 |
20160125133 | METHOD FOR POSITIVE FREQUENCY DATA ACCUMULATION AND APPARATUS FOR FILTERING GENETIC VARIANTS USING THE SAME - Provided are a method and apparatus for accumulating positive frequency data. The method includes receiving result data of pooling tests performed on a plurality of pools on a two dimensional (2D) matrix, the pooling test result data including allele frequencies of positive pools for a standard variant, predicting the number of positive samples for the standard variant from the allele frequencies of the positive pools, calculating a positive frequency for the standard variant from the number of positive samples, and updating the positive frequency for the standard variant to positive frequency database. | 05-05-2016 |
20160125134 | Automated Classification of Cells in Biologic Mixtures Analyzed by High Parameter Cytometry Instrumentation, Processing, System and Method - A processing, system and method for automated classification of cells in biologic mixtures analyzed by high parameter cytometry instrumentation is disclosed. A signal processor is configured to automatically pre-process the data from a mass cytometer configured to process data marked into a number of channels in a manner that enables subsequent automated classification, clustering and profiling of defined cell types. The method comprises performing the steps of identifying, computing and replacing event values marked into a given marker channel from the mass cytometer, | 05-05-2016 |
20160125151 | Physiological Parameter Measuring Platform Device Supporting Multiple Workflows - A device obtains a series of measurements of a physiological parameter of a monitored patient when the device is operating within a monitoring workflow. The device displays a monitoring workflow home screen when the device is operating within the monitoring workflow. The monitoring workflow home screen contains a representation of the physiological parameter of the monitored patient. In addition, the device obtains a measurement of the physiological parameter of each patient in a series of patients when the device is operating within a non-monitoring workflow. The device displays a non-monitoring workflow home screen when the device is operating within the non-monitoring workflow. The non-monitoring workflow home screen contains a representation of the physiological parameter of a given patient in the series of patients. The monitoring workflow home screen is different than the non-monitoring workflow home screen. | 05-05-2016 |
20160131574 | METHOD FOR SCREENING VITAMIN D INSUFFICIENCY USING SKIN COLOURIMETRY - The present application provides a method for establishing a protocol for screening vitamin D (vit-D) insufficiency in a population of interest, a method for screening Vit-D insufficiency using the protocol, and a device for screening Vit-D insufficiency developed based on the protocol. | 05-12-2016 |
20160132634 | COMPUTER-IMPLEMENTED METHODS OF DETERMINING PROTEIN VISCOSITY - The invention provides computer-implemented methods for screening proteins such as antibodies based on viscosity properties. The methods involve making a spatial charge map (SCM) of the three-dimensional structure of the antibody or protein and determine a SCM score depending on a condition such as e.g. pH, which score correlates with the viscosity. Thus a quantitative measure of the viscosity is obtained. | 05-12-2016 |
20160132636 | MANAGING GENE SEQUENCES - A method and apparatus for determining similarity among gene sequences, for compressing a gene sequence, and for decompressing a gene sequence. The method for determining similarity between a first gene sequence and a second gene sequence includes: moving a sliding window of a predefined length on the first gene sequence and the second gene sequence respectively; extracting a first part String | 05-12-2016 |
20160132637 | NOISE MODEL TO DETECT COPY NUMBER ALTERATIONS - This disclosure relates to systems and methods that employ a noise model generated from control samples to detect copy number alterations (CNA) in one or more test samples. The noise model can be generated to represent an indication of noise associated with chromosomes of control biological samples obtained via a common protocol. The indication can be determined by comparing chromosomes of the control biological samples. The noise model can be used to detect CNAs within the test sample by analyzing variability thereof with respect to the noise model. | 05-12-2016 |
20160132655 | ENDOBIOGENIC-BASED PROCESSING OF BIOLOGICAL DATA - A method is provided that includes processing biological data using a biological simulation model, including calculating a set of measurements called indexes that measure interrelationships between hormones and/or blood test data; and analyzing from the indexes, the endocrine system by axis and in sequence along an adaptation process. The method includes running a selection algorithm from the indexes to identify biological dysfunctions across the endocrine system and the autonomous nervous system, and recommending corrective actions based on the identified biological dysfunctions. The method includes validating potential organism dysfunctions of the patient through the identified biological dysfunctions, consolidating diagnostic actions including the recommended corrective actions into a single diagnostic, and receiving selection of diagnostic actions therefrom. And the method includes assisting in selection of a therapeutic strategy applicable to each selected diagnostic action, and producing a final ready-to-use prescription with quantified dosage based thereon. | 05-12-2016 |
20160135718 | PHASE-TO-AMPLITUDE/SLOPE MAPPING - A method includes obtaining a signal that includes a plurality of cycles and generating a map that maps motion phases to the signal based on both an amplitude and a slope of the signal. A system includes a processor that identifies a set of motion signal timestamps, for a plurality of motion cycles in a motion signal indicative of cyclic motion of a moving object, based on a predetermined motion phase of interest and a phase-to-amplitude/slope mapping, wherein the set of motion signal timestamps correspond to a common signal amplitude. A method include identifying a peak of a plurality of peaks in a motion cycle of a noisy cyclic signal having irregular periodicity, wherein the peak corresponds to a point lying between two points with amplitudes below a predetermined threshold, comparing points before and after the peak with the peak, and identifying the peak as a local maximum when the peak is greater than the points. | 05-19-2016 |
20160139080 | CHARACTERIZATION OF BLOOD HEMOSTASIS AND OXYGEN TRANSPORT PARAMETERS - An integrated system for determining a hemostasis and oxygen transport parameter of a blood sample, such as blood, is disclosed. The system includes a measurement system, such as an ultrasonic sensor, configured to determine data characterizing the blood sample. For example, the data could be displacement of the blood sample in response to ultrasonic pulses. An integrated aspect of the system may be a common sensor, sample portion or data for fast and efficient determination of both parameters. The parameters can also be used to correct or improve measured parameters. For example, physiological adjustments may be applied to the hemostatic parameters using a HCT measurement. Also, physical adjustments may be applied, such as through calibration using a speed or attenuation of the sound pulse through or by the blood sample. These parameters may be displayed on a GUI to guide treatment. | 05-19-2016 |
20160140288 | METHOD FOR FORMING PERSONAL NUTRITION COMPLEX ACCORDING TO INCIDENCE OF DISEASE AND GENETIC POLYMORPHISM BY A PREDICTION SYSTEM - The present invention relates to a system for predicting an incidence of disease from genetic polymorphism and uses the prediction result to form a personal nutrition complex. The system collects at least one personal information and single nucleotide polymorphism (SNP) information then exchanges the above information with databases including a personal database, a genetic risk database, an allelic frequency database, and a prevalence database. Finally, the system will output a prediction report and indicates a risk of specific disease and a plurality of abnormal genes. According to the prediction results, the system also can provide a plurality of nutritional supplement ingredients to form a personal nutrition complex. Users can receive a comprehensive and an effective nutritional supplement countermeasure about abnormal genes for prevention of the specific disease. | 05-19-2016 |
20160140312 | GENERATING DRUG REPOSITIONING HYPOTHESES BASED ON INTEGRATING MULTIPLE ASPECTS OF DRUG SIMILARITY AND DISEASE SIMILARITY - Various embodiments predict drug-disease associations. In one embodiment, a plurality of disease similarity matrices and a plurality of disease similarity matrices are accessed. Each of the plurality of drug similarity matrices is associated with a different drug information source. Each of the plurality of disease similarity matrices is associated with a different disease information source. A known drug-disease association matrix is also accessed. The known drug-disease association matrix indicates if a given drug identified is known to treat a given disease. At least one drug-disease association prediction is generated based on the plurality of drug similarity matrices, the plurality of disease similarity matrices, and the known drug-disease association matrix. The at least one drug-disease association prediction identifies a previously unknown association between a given drug and a given disease, and a probability that the given disease is treatable by the given drug. | 05-19-2016 |
20160147936 | RATIONAL METHOD FOR SOLUBILISING PROTEINS - A method and data processing system for identifying mutations or insertions that alter a property such as the solubility or aggregation propensity of an input polypeptide chain. The method comprises inputting a sequence of amino acids and a structure for said sequence for said target polypeptide chain; calculating a structurally corrected solubility or aggregation propensity profile for said target polypeptide chain; selecting, using said calculated profile, regions within said target polypeptide chain; identifying at least one position within each selected region suitable for mutations or insertions; generating a plurality of mutated sequences by mutations or insertions at least one identified position; and predicting a value of the solubility or aggregation propensity for each of the plurality of mutated sequences whereby any alteration to the solubility or aggregation propensity of the input polypeptide chain is identified. Predicting a value for solubility or aggregation propensity comprises: inputting each of the plurality of mutated sequences as an input polypeptide chain into a data processing system comprising a first trained neural network having a first function mapping an input to a first output value and a second trained neural network having a second function mapping an input to a second output value; generating a first output value of said solubility or aggregation propensity for each said input polypeptide chain using said first trained neural network; generating a second output value of said solubility or aggregation propensity for each said input polypeptide chain using said second trained neural network; and combining the first and second output values to determine a combined output value for the solubility or aggregation propensity. | 05-26-2016 |
20160154931 | METHOD AND DEVICE FOR DETECTING CHROMOSOMAL ANEUPLOIDY | 06-02-2016 |
20160154944 | SYSTEMS AND METHODS FOR VESSEL REACTIVITY TO GUIDE DIAGNOSIS OR TREATMENT OF CARDIOVASCULAR DISEASE | 06-02-2016 |
20160157783 | SYSTEM AND METHOD FOR BIOLOGICAL SIGNAL PROCESSING WITH HIGHLY AUTO-CORRELATED CARRIER SEQUENCES - A computer-implemented method for biological signal recording, including modulating a sampled evoked biological signal with a carrier sequence code resulting in a modulated evoked biological signal. The carrier sequence code has an autocorrelation function. The method includes demodulating the modulated evoked biological signal by calculating a convolution of the modulated evoked biological signal with the carrier sequence code resulting in an evoked biological signal spectrum. The evoked biological signal spectrum has a peak to sideband ratio as a function of the carrier sequence code. The method includes calculating deviations between each element of the sampled evoked biological signal and the peak to sideband ratio and filtering noise artifacts from the sampled evoked biological signal based on the deviations. Peak to sideband ratios may also be optimized by varying the sampling rate. | 06-09-2016 |
20160160259 | AUTOMATED DETECTION OF ASSAY-POSITIVE AREAS IN MICROFLUIDIC DEVICES - Methods are provided for the automated detection of assay-positive assay areas in a microfluidic device. When assays are performed in a microfluidic device, the configuration of the microfluidic circuit and its constituent circuit elements can determine where the reagents/analytes used in the assay can be located within the microfluidic circuit. Methods are provided for automatic identification of the size and shape of the assay areas based on a number of parameters which may include type of assay involved, shape and dimensions of microfluidic circuit elements, velocity and physical characteristics of the fluidic medium within the microfluidic circuit, physical/chemical properties of the analytes/reagents, and/or the number of cells being assayed. | 06-09-2016 |
20160161466 | SCALABLE AND HIGH THROUGHPUT BIOSENSING PLATFORM - A multi-channel high performance embedded system is provided, which is capable of high throughput biological analysis. A configurable acquisition and processing architecture combines dedicated co-processors to perform signal filtering and other computational demanding tasks, with a central processor controlling the whole system. The mapping of the architecture into an architecture, such as the Zynq SoC, demonstrates the ability of the biosensing platform to support a significant number of sensors, while ensuring a high sampling frequency. Furthermore, the Zynq reconfiguration abilities provide a mechanism to adapt the processing and maximize the biological sensitivity. | 06-09-2016 |
20160162634 | ANALYSIS OF A POLYMER COMPRISING POLYMER UNITS - A sequence of polymer units in a polymer ( | 06-09-2016 |
20160162653 | REDUNDANT ERROR DETECTION IN A CLINICAL DIAGNOSTIC ANALYZER - Disclosed is a clinical diagnostic analyzer employing a redundant error detection capability to further examine the internal message traffic for possible errors or questionable results by comparing the actual parameters against a fingerprint generated for each assay using an assay database and a configuration file. This testing does not rely on inputs from the software module being tested, and hence is an independent test. Further, a testing mechanism is provided to test the Redundant Error Detection (“RED”) capability itself. | 06-09-2016 |
20160163523 | METHOD FOR COMPUTER-ASSISTED ANALYSIS OF ONE OR MORE TISSUE SECTIONS OF THE HUMAN OR ANIMAL BODY - A method for computer-assisted analysis of one or more tissue sections of the human or animal body for preparing a digital stain test is provided. During the digital stain test, tissue zones in a tested tissue section with a predetermined clinical picture are detected. Spatially resolved hyperspectral data, particularly mass spectrometry data, is processed for a plurality of measurement positions. Multiple base spectra are determined from the hyperspectral data by obtaining base vectors. The base spectra are correlated with the hyperspectral data such that a plurality of correlation values for the base spectra is obtained for each measurement position. Subsequently, a regression model is calculated using a regression method, the regression model describing a mask of the one or more tissue sections, in which mask diseased tissue zones are marked based on the calculated correlation values. The regression model and the base spectra can then be used to conduct the digital stain test. | 06-09-2016 |
20160166096 | Device to Measure and Monitor Drinking and Eating | 06-16-2016 |
20160169861 | Method and Apparatus for Evaluating Values Representing A Mass or A Concentration of A Substance Present Within the Body of A Patient | 06-16-2016 |
20160171172 | METHOD AND SYSTEM OF LONGITUDINAL DETECTION OF DEMENTIA THROUGH LEXICAL AND SYNTACTIC CHANGES IN WRITING | 06-16-2016 |
20160174912 | LONG TERM HARM DETECTION WEARABLE DEVICE | 06-23-2016 |
20160174946 | SYSTEM FOR TRACKING FEMALE FERTILITY | 06-23-2016 |
20160180019 | Bioinformatics Systems, Apparatuses, And Methods Executed On An Integrated Circuit Processing Platform | 06-23-2016 |
20160180060 | SYSTEMS AND METHODS FOR MONITORING MOVEMENT OF DISEASE FIELD | 06-23-2016 |
20160183858 | END OF LIFE DETECTION FOR ANALYTE SENSORS - Systems and methods for processing sensor data and end of life detection are provided. In some embodiments, a method for determining the end of life of a continuous analyte sensor includes evaluating a plurality of risk factors using an end of life function to determine an end of life status of the sensor and providing an output related to the end of life status of the sensor. The plurality of risk factors may be selected from the list including the number of days the sensor has been in use, whether there has been a decrease in signal sensitivity, whether there is a predetermined noise pattern, whether there is a predetermined oxygen concentration pattern, and error between reference BG values and EGV sensor values. | 06-30-2016 |
20160188794 | Systems and Methods for Error Correction in DNA Sequencing - Disclosed are systems and methods for polynucleotide sequencing where detection and correction of base calling errors can be achieved without reliance on a reference sequence. In certain embodiments, redundant information can be introduced during measurement so as to allow such detection of errors. Such redundant information and measurements can be facilitated by encoding of nucleotide sequence being measured. Various examples of such encoding, redundancy introduction, and decoding are provided. | 06-30-2016 |
20160192887 | PHYSIOLOGICAL PARAMETER PROCESSING METHOD AND SYSTEM AND MONITORING DEVICE USING THE SAME | 07-07-2016 |
20160196235 | METHOD AND APPARATUS FOR DETERMINING A SMOOTHED DATA POINT WITHIN A STREAM OF DATA POINTS | 07-07-2016 |
20160196383 | CLOUD SYSTEM FOR MENSTRUAL CYCLE PREDICTION AND METHOD THEREOF | 07-07-2016 |
20160249852 | INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND PROGRAM | 09-01-2016 |
20160249855 | ITEM ATTACHABLE TO A SUBJECT AND INCLUDING A SENSOR FOR SENSING AN OBJECT THAT A BODY PORTION OF THE SUBJECT MAY CONTACT | 09-01-2016 |
20160249863 | HEALTH CONDITION DETERMINATION METHOD AND HEALTH CONDITION DETERMINATION SYSTEM | 09-01-2016 |
20160252483 | METHODS OF NORMALIZING MEASURED DRUG CONCENTRATIONS AND TESTING FOR NON-COMPLIANCE WITH A DRUG TREATMENT REGIMEN | 09-01-2016 |
20160252484 | SYSTEM AND METHOD FOR MODIFIED GAS CHROMATOGRAPHIC DATA ANALYSIS | 09-01-2016 |
20160253454 | METHOD OF EVALUATING FEMALE GENITAL CANCER | 09-01-2016 |
20160374607 | METHOD FOR MONITORING EXCREMENT DATA - A method, data processing unit, and system for monitoring excrement data for seeking a pattern for a monitoring period, wherein said excrement data is associated with at least one absorbent article and a person wearing said at least one absorbent article is disclosed. The method includes acquiring excrement data including excrement data for at least two different time periods, each substantially corresponding to the monitoring period for which a pattern of events is sought, wherein said excrement data includes information of excrement into an absorbent article in form of excrement events, and wherein each excrement event has an associated time mark or associated information from which an associated time mark may be derived; and smoothing the time mark of each excrement event. | 12-29-2016 |
20160377638 | Blood Testing System and Method - Some embodiments of a blood coagulation testing system include an analyzer console device and a single-use components configured to releasably install into the console device. In some embodiments, the blood coagulation testing system can operate as an automated thromboelastometry system that is particularly useful, for example, at a point-of-care site. The systems can be configured with features such as individual actuation systems for each measurement module, and firmware for initial and ongoing calibration and error detection. | 12-29-2016 |
20160378914 | METHOD OF AND APPARATUS FOR IDENTIFYING PHENOTYPE-SPECIFIC GENE NETWORK USING GENE EXPRESSION DATA - In a method of identifying a phenotype-specific gene network using gene expression data, gene networks are generated using the gene expression data and biological interaction data, a sub-network commonly existing among generated gene networks is searched for, one or more clusters are extracted from a common sub-network, and a cluster related to a change of a phenotype of a biological sample is determined by verifying significance for each of extracted one or more clusters. | 12-29-2016 |
20170231561 | DRUG EFFICACY EVALUATION ASSISTING SYSTEM, AND DRUG EFFICACY EVALUATION ASSIST INFORMATION PRESENTING METHOD | 08-17-2017 |
20170234798 | METHOD AND DEVICE FOR DIAGNOSING VIRAL INFECTION USING TEARDROP | 08-17-2017 |
20170235873 | SYSTEMS AND METHODS FOR TRACKING AND IDENTIFYING INFECTION TRANSMISSION | 08-17-2017 |
20180020908 | SYSTEMS AND METHODS FOR DETERMINING RETINAL GANGLION CELL POPULATIONS AND ASSOCIATED TREATMENTS | 01-25-2018 |
20180020986 | METHOD, STORAGE MEDIUM AND ELECTRICAL DEVICE FOR OBTAINING CYCLE OF PHYSIOLOGICAL SIGNAL | 01-25-2018 |
20180025110 | ANALYZING CHARACTERISTICS OF GENOMIC REGIONS OF A GENOME | 01-25-2018 |
20190141914 | SYSTEMS AND METHODS FOR MONITORING MOVEMENT OF DISEASE FIELD | 05-16-2019 |
20190145894 | Determining Characteristics of Enzyme Catalysis | 05-16-2019 |
20190147136 | Method of Using Machine Learning Algorithms in Analyzing Laboratory Test Results of Body Fluid to Detect Microbes in the Body Fluid | 05-16-2019 |
20190147976 | CHECKPOINT FAILURE AND METHODS THEREFOR | 05-16-2019 |
20190147979 | Electronic Methods And Systems For Microorganism Characterization | 05-16-2019 |
20190147981 | Bioinformatics Systems, Apparatuses, and Methods Executed on an Integrated Circuit Processing Platform | 05-16-2019 |
20190147982 | COMPOSITIONS AND METHODS RELATED TO OBSTRUCTIVE SLEEP APNEA | 05-16-2019 |
20190147984 | Modifying a Cosmetic Product Based on a Microbe Profile | 05-16-2019 |
20190147986 | METHODS FOR ASSESSING NEOADJUVANT THERAPIES | 05-16-2019 |
20190148001 | CLOUD-ASSISTED REHABILITATION METHODS AND SYSTEMS FOR MUSCULOSKELETAL CONDITIONS | 05-16-2019 |
20220133239 | METHOD AND APPARATUS FOR WIDE-BAND PHASE GRADIENT SIGNAL ACQUISITION - The present disclosure facilitates capture (e.g., bipolar capture) of differentially-acquired wide-band phase gradient signals (e.g., wide-band cardiac phase gradient signals, wide-band cerebral phase gradient signals) that are simultaneously sampled. Notably, the exemplified system minimizes non-linear distortions (e.g., those that can be introduced via certain filters such as phase distortions) in the acquired wide-band phase gradient signals so as to not affect the information therein that can non-deterministically affect analysis of the wide-band phase gradient signal in the phase space domain. Further, a shield drive circuit and shield-drive voltage plane may be used to facilitate low noise and low interference operation of the acquisition system. | 05-05-2022 |
20220136961 | METHOD FOR CALIBRATING A PHOTOMETRIC ANALYZER - The present disclosure discloses a method for calibrating a photometric analyzer which is designed to determine the silicate content of an analyte, comprising the steps of: detecting a first measurement point, with the steps of adding a first reagent to a sample of a first calibration standard, adding a second reagent to this sample, adding a third reagent to this sample; detecting a second measurement point, wherein the second measurement point differs from the first measurement point, with the steps of adding the second reagent to a sample of a second calibration standard, adding the first reagent to this sample, adding a third reagent to this sample; determining the zero point and the slope of the calibration line using the first and second measurement points. | 05-05-2022 |
20220137012 | METHOD FOR ANALYZING DIFFERENTIATION OF METABOLITES IN URINE SAMPLE BETWEEN DIFFERENT GROUPS - The present invention relates to a method for metabolite sampling and analysis for reproducibly sampling as many metabolites as possible in a urine sample without changing to metabolites. The method has effects of presenting a biomarker detection method according to the sex or the like, by establishing optimal conditions for metabolite sampling in urine samples and presenting a metabolite comparison analysis method between different groups on the basis of the optimal conditions. | 05-05-2022 |
20220137013 | COMPONENT MANAGEMENT SYSTEM FOR ANALYSIS DEVICE AND COMPONENT MANAGEMENT PROGRAM - A component management system for an analysis device, includes a plurality of analysis devices, and a server connected to the plurality of devices via a network, wherein each analysis device includes an acquirer that acquires a behavior information piece associated with a use amount of a component attached to each analysis device, and a transferer that transfers the behavior information piece acquired by the acquirer to the server, and the server includes a registrar that registers the behavior information pieces received from the plurality of analysis devices in a database, and a comparison information provider that provides comparison information, of a same type of components that are used in the plurality of analysis devices, produced based on the behavior information pieces registered in the database. | 05-05-2022 |
20220137019 | HYPERSPECTRAL COMPUTER VISION AIDED TIME SERIES FORECASTING FOR EVERY DAY BEST FLAVOR - In some embodiments, apparatuses and methods are provided herein useful to determining a flavor profile for an item. In some embodiments, a computing system for determining a flavor profile of an item comprises a memory device storing computer-executable instructions and a processor configured to execute the computer-executable instructions to obtain a spectral profile associated with the item, identify at least one attribute value for at least one attribute of the item based on the received spectral profile, determine a flavor score for the item based on the at least one attribute value, obtain time series data associated with the item corresponding to a number of days, calculate a predicted flavor score for the item relative to the number of days based on the received time series data, and generate a flavor profile for the item based at least on the predicted flavor score. | 05-05-2022 |
20220139496 | RECOMBINASE-RECOGNITION SITE PAIRS AND METHODS OF USE - The present disclosure provides methods, compositions, kits, and systems for identifying recombinases and cognate site-specific recombinase recognition sites as well as method for using the identified recombinase/recognition site pairs. | 05-05-2022 |