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Tissue

Subclass of:

623 - Prosthesis (i.e., artificial body members), parts thereof, or aids and accessories therefor

623110110 - IMPLANTABLE PROSTHESIS

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Class / Patent application numberDescriptionNumber of patent applications / Date published
623230740 Having textured surface 15
623230730 Having micro particles 2
20110288656TISSUE GRAFT COMPOSITIONS AND METHODS FOR PRODUCING SAME - A tissue graft composition is described herein that includes a segment of small intestinal submucosa having at least one nanoparticle incorporated therein such that the permeability of the segment of small intestinal submucosa is altered, thereby providing the segment of small intestinal submucosa with a more substantially uniform structure for cell migration and proliferation. The tissue graft composition may further comprise at least one macromolecule incorporated into the nanoparticle. The tissue graft composition may be utilized in seeded or unseeded methods of tissue repair.11-24-2011
20090024229Devitalization and recellularization of cartilage - The present invention is directed toward recellularizing a devitalized cartilage graft with viable recellularizable cells in vivo, in situ, or in vitro to render the tissue vital. The present invention is also directed toward repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, recellularizing the devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally stored between the removing cellular debris and the recellularizing steps. The present invention is directed to both recellularized cartilage grafts as well as a process for recellularizing cartilage grafts.01-22-2009
Entries
DocumentTitleDate
20110184530High performance reticulated elastomeric matrix preparation, properties, reinforcement, and use in surgical devices, tissue augmentation and/or tissue repair - This invention relates to reticulated elastomeric matrices, their manufacture, their post-processing, such as their reinforcement, compressive molding or annealing, and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for surgical devices, tissue augmentation, tissue repair, therapeutic, nutritional, or other useful purposes.07-28-2011
20130030548Engineered Tissue Implants And Methods Of Use Thereof - A engineered tissue implant comprising a perfusion chamber formed with a biocompatible flexible tubular member having a wall defining an internal fluid flow passage and a porous scaffold within the fluid flow passage of the tubular member, the porous scaffold arranged such that, in a presence of a perfusion fluid, the perfusion fluid will flow through the porous scaffold and be inhibited from flow between the porous scaffold and the wall of the tubular member. The engineered tissue implant may be understood as a transplantable cell construct or as an implantable bioreactor for cell growth both in vitro and/or in vivo. A method to provide tissue for reconstruction may comprise forming the engineered tissue implant containing a scaffold, introducing and seeding cells to the scaffold, introducing a perfusion fluid to the scaffold which flows through the fluid flow passage and scaffold, proliferating the cells within the scaffold and forming blood vessels within the scaffold. This may be followed by transplanting the engineered tissue implant in vivo where nutrition and oxygen are provided to support the preloaded cells.01-31-2013
20130085579METHOD AND APPARATUS FOR A PROCESS CREATING AN INTERNAL TISSUE GRAFT FOR ANIMAL AND HUMAN RECONSTRUCTIVE PURPOSES - A method and apparatus is provided for creating an internal reconstruction tissue graft. Templates may be used to create a multitude of patterns in a variety of tissue reconstruction grafts. An apparatus may be used to create an internal tissue graft for reconstruction through either compression and/or removal of segments. An apparatus may be used, through either compression and or removal of segments of a preformed template made of synthetics and or metal that minors a template that can be used as an internal tissue graft for reconstruction. In a method, such as using software analysis and an apparatus, the physical properties of the tissue graft and its pre- and post-operative properties and appearance may be measured.04-04-2013
20110202142BIOLOGICALLY DERIVED COMPOSITE TISSUE ENGINEERING - The present application is directed to engineering of tissues, especially composite tissues such as a joint. Various aspects of the application provide tissue modules and methods of fabrication and use thereof. Some embodiments provide a tissue module that can be fabricated to be substantially similar in anatomic internal and external shape as a target tissue. Some embodiments provide a composite tissue module having a plurality of layers, each of which simulate a different tissue (e.g., bone and cartilage of a joint).08-18-2011
20120245706MESH ENCLOSED TISSUE CONSTRUCTS - Described is a scaffold that is strong enough to resist forces that exist inside a body, while possessing biocompatible surfaces. The scaffold is formed of a layer of mesh (e.g., Stainless Steel or Nitinol) that is tightly enclosed by a multi-layer biological matrix. The biological matrix can include three layers, such a first layer (smooth muscle cells) formed directly on the metal mesh, a second layer (fibroblast/myofibroblast cells) formed on the first layer, and a third layer (endothelial cells) formed on the second layer. The scaffold can be formed to operate as a variety of tissues, such as a heart valve or a vascular graft. For example, the mesh and corresponding biological matrix can be formed as leaflets, such that the scaffold is operable as a tissue heart valve.09-27-2012
20130079891TISSUE MODIFICATION - A tissue modification apparatus includes a first and a second guide, a first and a second set of mounts, and a first and a second actuator. The first guide defines a first axis, and the second guide defines a second axis intersecting the first axis. The mounts of the first set of mounts are movable relative to one another along the first axis, and the mounts of the second set of mounts are movable relative to one another along the second axis. The first actuator and the second actuator are each settable to a stress load, with the first actuator and the second actuator movable, respectively, along the first axis and the second axis to transmit each respective stress load to a piece of tissue mechanically coupled to the first and second set of mounts.03-28-2013
20130035767NEURAL GRAFT - A neural graft includes a biological substrate, a carbon nanotube structure and a neural network. The carbon nanotube structure is located on the biological substrate. The carbon nanotube structure includes a number of carbon nanotube wires crossed with each other to define a number of pores. The neural network includes a number of neural cell bodies and a number of neurites branched from the neural cell bodies. An effective diameter of each pore is larger than or equal to a diameter of the neural cell body, the neurites substantially extend along the carbon nanotube wires such that the neurites are patterned.02-07-2013
20130035768VARIABLE DENSITY TISSUE GRAFT COMPOSITION - Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient.02-07-2013
20100324697System and method for a piezoelectric scaffold for nerve growth and repair - Provided is an electroactive structure for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure.12-23-2010
20090157194IMPLANT COMPOSITE MATERIAL - An implant composite material is provided which is for use in the treatment of articular cartilage disorders such as hip joint femur head necrosis and knee joint bone head necrosis, the reconstruction/fixing of a bio-derived or artificial ligament or tendon, the uniting/fixing of a bone, etc. Part of the implant composite material is replaced by bone tissues in an early stage to enable the material to stably bond with a living bone, while the other part retains a necessary strength over a necessary time period. Finally, the implant composite material is wholly replaced by the living bone and disappears.06-18-2009
20090157193Tendon and Ligament Repair Sheet and Methods of Use - Methods and device for treating or healing an injured tendon or ligament is disclosed. The device, a tendon and ligament repair sheet, has a porous layer and a denser layer, and optionally a therapeutic agent in the porous layer, the denser layer or both. The repair sheet is made from a resorbable or non-resorbable polymer. The repair sheet is securely attached to the injured tendon, ligament, muscle, or bone and has a suture pull out strength of at least 3N. If the injury involve severing of a ligament or tendon, one should place the severed ends in close proximity to each other and securely attach the repair sheet to both sides of the severed tendon or ligament at a distance from the injury so that the repair sheet remains securely attached to the tendon, ligament, muscle, or bone while the tissue is healing.06-18-2009
20090306790Elastase Treatment of Tissue Matrices - A method of producing a modified acellular tissue matrix (mATM) from an acellular tissue matrix (ATM), where the mATM has a reduced stretchiness relative to the ATM, without substantially compromising its associated structural or functional integrity. The method includes providing an acellular tissue matrix (ATM) and exposing the ATM to elastase for a period of time.12-10-2009
20090112332BONE GRAFT AND BONE GRAFT SUBSTITUTES WITH ANTIBIOTICS FOR SUSTAINED, LOCALIZED RELEASE OF ANTIBIOTICS FOR REDUCING POSTOPERATIVE SURGICAL WOUND INFECTION IN SPINAL AND OTHER BONE SURGERY - A bone graft or bone graft substitute material containing antibiotics is formed into crumbs, powder, putty, flexible sheets, or other form for localized delivery of drugs. The material is adapted to be placed inside a body for sustained, localized delivery of antibiotics. The antibiotics may be in a crystalline or non-crystalline form.04-30-2009
20120191216VOLUMETRIC GRAFTS FOR TREATMENT OF FISTULAE AND RELATED METHODS AND SYSTEMS - Described are devices, methods, and systems useful in the treatment of fistulae, and in certain embodiments those having openings extending into the alimentary canal, such as anorectal fistulae. Illustratively, an anorectal fistula can be treated by placing a volumetric construct within the primary opening of the fistula. In certain embodiments, the volumetric construct can include a rolled remodelable material processed to form a substantially unitary body. Advantageous such remodelable materials can include collagenous extracellular matrix materials, such as small intestine submucosa.07-26-2012
20130073054TISSUE SUPPORT STRUCTURE - An apparatus includes a component having a shape memory material. The shape memory material has a first shape including a substantially elongate segment. The shape memory material has a second shape including a helix having a first ring and a second ring configured to exert a compressive force on a membrane interleaved between the first ring and the second ring and lying in a plane substantially perpendicular to an axis of the helix, the shape selectable based on an external stimulus.03-21-2013
20110015760IMPLANTABLE PROSTHESIS - A prosthetic device including biologically compatible and preferably fully resorbable materials includes a tissue infiltratable portion and a second portion. The two portion may have different rates of resorption. The ingrowth portion may include a plurality of openings to encourage tissue ingrowth and vascularization. The second portion may be stronger than the ingrowth portion and provide a location for fixation of the device. The portion may be attached using resorbable adhesives, sutures or other constructs to render a fully resorbable prosthesis.01-20-2011
20110015759ADHERING COMPOSITION AND METHOD OF APPLYING THE SAME - A method of in-situ adhering including providing pre-gel including phenolic compound and water miscible polymers like carbohydrates, salts of anionic polysaccharide, spreading layer of pre-gel onto a surface, adding solid support, comprising cross linking agents capable of interacting with the polymer, to pre-gel, and allowing pre-gel to cure and adhere onto surface.01-20-2011
20090270999PATCH FOR ENDOSCOPIC REPAIR OF HERNIAS - In some embodiments, a method of repairing a hernia may include one or more of the following steps: (a) introducing a patch prosthesis into a patient, (b) positioning the patch prosthesis over the hernia, (c) removing a wire frame from the patch prosthesis and the patient, (d) wrapping the patch prosthesis, (e) allowing the patch prosthesis to unwrap, (f) removing a removable stitch coupling the wire frame and a prosthetic fabric, and (g) securing the prosthetic fabric to the patient.10-29-2009
20130066438SYNTHETIC SCAFFOLDS AND ORGAN AND TISSUE TRANSPLANTATION - Articles, compositions, and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. Synthetic scaffolds for growing artificial tissue and organ transplants are also provided.03-14-2013
20090240341TISSUE PROSTHESIS AND A METHOD OF, AND EQUIPMENT FOR, FORMING A TISSUE PROSTHESIS - A tissue prosthesis 09-24-2009
20090012629COMPOSITIONS AND METHODS FOR TISSUE REPAIR - Implants for repairing tissue defects, such as cartilage tissue defects, and methods of their preparation and use are disclosed. A mold of a tissue defect is prepared by pressing upon the defect a substrate having shape memory, such as aluminum foil. The mold, which has contours substantially conforming to those of the defect, is removed from the defect, and tissue particles are added to the mold ex vivo. A biological carrier such as biocompatible glue is also added to the mold. The combination of tissue particles and the biological carrier thereby form an implant, which retains its shape after separation from the mold. The implant can be transferred to the tissue defect, with contours of the mold matching corresponding contours of the defect.01-08-2009
20090012628Method for use of a double-structured tissue implant for treatment of tissue defects - A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit.01-08-2009
20090012627Double-structured tissue implant and a method for preparation and use thereof - A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.01-08-2009
20090118838Materials Useful for Support and/or Replacement of Tissue and the Use Thereof for Making Prostheses - The invention relates to a material providing support and/or replacement of living tissues and the use thereof for manufacturing prostheses. The material according to the invention comprises microparticles of a biomaterial coated with polyelectrolyte multilayers containing one or more biologically active products.05-07-2009
20120271432METHODS AND DEVICES FOR DELIVERING AND AFFIXING TISSUE SCAFFOLDS - Methods and devices are provided for delivering and affixing tissue replacements. In one embodiment, a tissue scaffold can be delivered into a patient through a cannula to a cavity formed at a defect site in tissue, e.g., cartilage. A delivery shaft can be used to deliver the scaffold through the cannula, and a loading device can help load the scaffold onto the delivery shaft. A delivery guide device can position and temporarily hold the scaffold within the cavity. The delivery guide device can guide one or more surgical instruments to the scaffold to affix the scaffold within the cavity, e.g., to bone underlying the scaffold, using at least one securing mechanism.10-25-2012
20110087338Use of Epineural Sheath Grafts for Neural Regeneration and Protection - Described herein is conduit material that causes minimal inflammatory reaction, and serves as a structural guide for regenerating nerve tissue (e.g., axons). Thus, the invention is directed to methods of treating a nerve injury in an individual in need thereof. The methods employ an isolated, naturally occurring epineural sheath, and can be used, for example, to regenerate nerve tissue in an individual in need thereof. Also provided herein is a device for harvesting an epineural sheath.04-14-2011
20080281434Tissue Engineering Using Pure Populations Of Isolated Non-Embryoblastic Fetal Cells - The present invention relates to methods for the in vitro production of mammalian tissue replacements using substantially pure populations of isolated non-embryoblastic fetal cells having the capacity to differentiate into the cell type(s) that form(s) the native tissue. The tissue replacements engineered by the methods of the present invention are especially useful for the repair of non-functional or malfunctional cardiovascular structures in patients suffering from congenital cardiovascular disorders.11-13-2008
20110125289Implantable Graft to Close a Fistula - An implantable graft, which may be inserted into a fistula tract to occlude the primary opening of the fistula, is provided. To prevent unintentional displacement of the graft or extrusion of the graft from the fistula of a patient, the graft may be provided with a cap that extends laterally from at least one end of the body of the graft, where the cap may be integral with the body of the graft, attachable to at least one end of the body of the graft, and/or moveable along the body of the graft. The graft may also have a tail that extends from one end of the body of the graft to assist in placement of the graft in a fistula tract. The graft may be an integral unit made of a single material, such as a heterograft material, or may include distinct components made of the same or different materials. Methods for closing a fistula tract are also provided.05-26-2011
20110125288Tissue Augmentation Material And Method - A permanent, biocompatible material for soft tissue augmentation. The biocompatible material comprises a matrix of smooth, round, finely divided, substantially spherical particles of a biocompatible ceramic material, close to or in contact with each other, which provide a scaffold or lattice for autogenous, three dimensional, randomly oriented, non-scar soft tissue growth at the augmentation site. The augmentation material can be homogeneously suspended in a biocompatible, resorbable lubricious gel carrier comprising a polysaccharide. This serves to improve the delivery of the augmentation material by injection to the tissue site where augmentation is desired. The augmentation material is especially suitable for urethral sphincter augmentation, for treatment of incontinence, for filling soft tissue voids, for creating soft tissue blebs, for the treatment of unilateral vocal cord paralysis, and for mammary implants. It can be injected intradermally, subcutaneously or can be implanted.05-26-2011
20110125287Reinforced Tissue Patch - A method of improving the mechanical properties of a tissue patch is provided. The method includes the steps of providing a tissue patch and placing at least one barbed suture along at least a portion of the tissue patch. The method may further include the step of placing one or more additional barbed sutures in a laterally spaced relation to the barbed suture. The barbed suture may be biodegradable or non-biodegradable.05-26-2011
20110301717Supporting and Forming Transitional Material for Use in Supporting Prosthesis Devices, Implants and to Provide Structure in a Human Body - A transitional mesh and thread for use in the human body is dissolved. The transitional mesh being comprised of sections of non-absorbable mesh fabric with sections of absorbable mesh fabric, such that each non-absorbable section is attached to absorbable mesh fabric. The non-absorbable mesh sections can be overlaid with absorbable mesh which after it is absorbed leaves the non-absorbable mesh in an array without connection to each other. The thread to be used to create the mesh has non-absorbable fibers that can be discontinuous, loosely woven or embedded in an absorbable material. The fabric mesh itself can be loosely woven and coated with absorbable material. The patterns of non-absorbable mesh and space between non-absorbable mesh sections can be varied to provide various strengths and degrees of motion and movement. The mesh can also be coated with materials to reduce infection, provide tissue growth, reduce scar tissue or other medicinal purposes.12-08-2011
20120089238INTEGRATED ORGAN AND TISSUE PRINTING METHODS, SYSTEM AND APPARATUS - A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.04-12-2012
20080306611BIOCOMPATIBLE IMPLANTS AND METHODS OF MAKING AND ATTACHING THE SAME - The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attaching such implants are also provided.12-11-2008
20110264235ELECTROSTATIC-ASSISTED FIBER SPINNING METHOD AND PRODUCTION OF HIGHLY ALIGNED AND PACKED HOLLOW FIBER ASSEMBLY AND MEMBRANE - The invention provides a highly aligned and closely packed hollow fiber assembly, wherein the assemblies of fibrous membrane has a width-to-fiber diameter ratio (W/d) larger than 10 and the orientation of the fibers is no larger than +/−10°. Also provided is an electrospinning process for the preparation of the fiber assembly of the invention and its applications.10-27-2011
20110264236ENGINEERED CRANIOFACIAL CONSTRUCTS WITH COMPOSITE SCAFFOLD - The present invention provides for compositions and constructs for craniofacial reconstruction implants, and methods for making and using same. Specific embodiments provide for a biocompatible scaffold having an auricular shape and a permanent bendable framework within the scaffold, wherein the permanent bendable framework allows deformation and return to pre-deformation shape, and thus maintains the auricular shape of the scaffold.10-27-2011
20090048684METHODS OF FORMING A MULTILAYER TISSUE IMPLANT HAVING A COMPLIANCE THAT SIMULATES TISSUE - Disclosed are implantable tissue augmentation devices, methods, and associated tools. The devices include an inflatable body, having an inner layer and an outer layer. A valve is provided for permitting the introduction of and retaining inflation media. At least one pull tab is provided on an end of the implant, to assist in positioning the implant. Kits and systems are also disclosed.02-19-2009
20120109335METHOD AND APPARATUS FOR RESTORING ARTICULAR CARTILAGE - The present invention comprises the provision and use of new and improved arthroscopic instrumentation for (i) harvesting a tissue biopsy from a non-critical section of a joint, and (ii) sizing and seating an autologous graft at an implant site.05-03-2012
20110196508CARTILAGE REPAIR MIXTURE CONTAINING ALLOGRAFT CHONDROCYTES - The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or mixed polymers with allograft chondrocytes added in an amount ranging from 2.5×1008-11-2011
20090276056RESORBABLE CERAMICS WITH CONTROLLED STRENGTH LOSS RATES - Particular aspects provide bioresorbable and biocompatible compositions for bioengineering, restoring or regenerating tissue or bone, comprising a three-dimensional porous or non-porous scaffold material comprising a calcium phosphate-based ceramic having at least one dopant therein selected from metal ion or ion dopants and metal oxide dopants, wherein the composition is sufficiently biocompatible to provide for a cell or tissue scaffold, and resorbable at a controlled resorption rate for controlled stregthloss, depending on dopant composition, under body, body fluid or simulated body fluid conditions. Preferably, the at least one dopant is selected from the group consisting of Zn11-05-2009
20100280627DISSECTION AND RETRACTION DEVICE FOR VAGINAL SACRAL COLPOPEXY - In one embodiment the apparatus includes a first retractor, a second retractor, and a shaft. The shaft defines a central channel extending from a first end portion of the shaft to a second end portion of the shaft. The first retractor and the second retractor are configured to collectively form a lumen. The shaft is configured to be disposed within the lumen. In one embodiment method of disposing a graft within a body of a patient, includes making an incision in the body of the patient, inserting a medical device into the body of the patient through the incision, removing the shaft of the medical device from the body of the patient, and moving the first refractor within the body of the patient away from the second retractor.11-04-2010
20080208359DURAL GRAFT AND METHOD OF PREPARING THE SAME - A dural graft is provided having improved stiffness characteristics relative to conventional dural substitutes. The dural graft can be formed from a collagen material having a stiffness between about 0.1 pounds per inch (lb./in.) and 0.25 lb./in. Relative to the collagen material forming conventional dural graft substitutes, the decreased stiffness of the collagen material of the present dural graft can provide the graft with a relatively improved or increased pliability. As a result of the increased pliability, the dural graft can sufficiently conform to a curvature of a tissue surface to which it is applied, such as the curved surface of a meningeal membrane. The reduced stiffness of the collagen material can also provide for a relatively improved or increased flexibility or elasticity of the dural graft. The increased flexibility of the dural graft minimizes tearing of the graft when handled or manipulated during an implantation procedure.08-28-2008
20110172786Implantable Repair Device - An implantable prosthesis for repairing or reinforcing a tissue or muscle wall defect including a first composite structure including at least one layer of a non-absorbable material, wherein the first composite structure has a central portion sized and shaped to cover at least a portion of the tissue or muscle wall defect, and has an outer periphery. The prosthesis further includes a second structure having a reinforced central region and an outer peripheral edge, a reinforcing element positioned between the first and second structures, and having an outer periphery and a stiffness greater than that of the first and second structures, and at least one pulling element coupled to the reinforced central region of the second structure. The second structure is coupled to the first structure substantially only at their respective peripheries.07-14-2011
20090276057DOUBLE LAYER SURGICAL PROSTHESIS TO REPAIR SOFT TISSUE - A prosthesis for the treatment of hernias and/or laparoceles via an intraperitoneal route, having a mesh of filaments of non-resorbable and biocompatible polymer material having interstices permitting tissue growth and a sheet of polymer material having barrier properties and low adhesion to sensitive organs and tissues. The sheet is superimposed upon and joined to the mesh so as to form a stratified structure. In particular, the sheet is joined to mesh through a plurality of filaments located alongside each other at a spacing of not more than 5 mm. Each filament has a plurality of attachment sites to the mesh which are not more than 15 mm apart, and each length of filament between two successive attachment sites projects from the surface of the mesh facing sheet and is fused to the sheet.11-05-2009
20110172785COMPLIANT COMPOSITES FOR APPLICATION OF DRUG-ELUTING COATINGS TO TISSUE SURFACES - A compliant composite for delivering a bioactive agent including a scaffolding material and a polymer coating that together can be attached to compliant tissue surfaces is disclosed, along with methods for constructing and applying these composites. In some embodiments, the composite further comprises a barrier layer for localized delivery of the bioactive agent.07-14-2011
20090036996Knit PTFE Articles and Mesh - Disclosed is a knitted article, and a method of producing such an article, having at least one PTFE fiber with oriented fibrils forming multiple fiber cross-over points wherein PTFE fiber is self-bonded in at least one of the cross-over points.02-05-2009
20120296442SYSTEMS AND METHODS FOR INTRA-OPERATIVE PHYSIOLOGICAL FUNCTIONAL STIMULATION - Improved assemblies, systems, and methods provide safeguarding against tissue injury during surgical procedures and/or identify nerve damage occurring prior to surgery and/or verify range of motion or attributes of muscle contraction during reconstructive surgery. Embodiments of methods according to the present invention provide the ability to intra-operatively simulate post-operative physiologic function of a body part. Such methods may be used during various surgical procedures, including nerve transfer procedures. Included are one or more steps of confirming paralysis or a weakened condition of a body part, confirming responsivity or operability of transfer tissue to supplement the functionality of the paralyzed or weakened part, and intra-operatively simulating post-operative functionality of the transfer tissue to enhance and/or predict the outcome of the surgical procedure.11-22-2012
20110270412FABRICATION OF A VASCULAR SYSTEM USING SACRIFICIAL STRUCTURES - The first aspect of the present invention is directed to a method of producing a vascular network preform (VNP). This method involves forming a network of elongate fibers and at least one elongate structure from a sacrificial material. The diameter of the elongate structure is greater than that of the elongate fibers. The network of elongate fibers is placed in contact with at least one elongate structure either following or during forming the network of elongate fibers or forming the at least one elongate structure. A matrix is applied around the network of elongate fibers, in contact with the at least one elongate structure. The network of elongate fibers and elongate structure, within the matrix is sacrificed to form a preform. The resulting preform contains a vascular network of fine diameter tubes in contact with at least one elongate passage having a diameter greater than that of the fine diameter tubes. The resulting solid preform and methods of using it are also disclosed.11-03-2011
20110208320ABDOMINAL WALL TREATMENT DEVICES - Devices and methods for treating or repairing openings in an body wall are provided. The devices and methods can include acellular tissue matrices. The tissue matrices can be positioned within the abdominal opening and can be used to close the opening.08-25-2011
20080249637PARTIALLY BIODEGRADABLE THERAPEUTIC IMPLANT FOR BONE AND CARTILAGE REPAIR - Exemplary embodiment of the present invention is directed to an at least partially biodegradable implant suitable for implantation into a subject for repairing a bone or cartilage defect, comprising a three-dimensional open-celled framework structure made of a non-particulate first material, the framework structure being embedded in a second, non-particulate material different from said first material, or the open-celled framework structure being substantially completely filled with said second, non-particulate material, wherein at least one of the first material or the second material is at least partially degradable in-vivo. Furthermore, the present invention is directed to a method for repairing a bone or cartilage defect in a living organism, comprising implanting an implant according to the exemplary embodiment of the present invention into the defective bone or cartilage, or replacing the defective bone or cartilage at least partially.10-09-2008
20120296443SERICIN EXTRACTED FABRICS - Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.11-22-2012
20080288084Precursor of a tissue regenerating instrument provided with a swellable rod - The present invention provides a precursor for producing a tissue regenerating instrument that regenerates a tissue, including: a tube made of a biodegradable material provided with a lumen in a longitudinal direction; a rod made of a biodegradable material swellable with a softening solvent, fixed to an inner wall of the tube substantially parallel to the longitudinal direction of the tube; and a fixing means that fixes the rod to the inner wall of the tube, in which the rod in a non-swelled state has a occupied cross-sectional area perpendicular to the longitudinal direction is smaller than a cross-sectional area of the lumen of the tube, and the occupied cross-sectional area perpendicular to the longitudinal direction of the rod in a saturated swelled state with the softening solvent is substantially the same as the cross-sectional area of the lumen of the tube.11-20-2008
20080312751Tissue patches and related delivery systems and methods - Endoluminally delivered tissue patches and related systems and methods for delivering the tissue patches for treating lesions of the alimentary tract are disclosed. A tissue patch includes a substrate, a tissue implant attached to the substrate, and a protective liner covering at least a portion of the tissue implant. A method includes providing a tissue patch having a tissue implant attached to a substrate and a protective liner covering at least a portion of the tissue implant. The tissue patch is formed into a contracted state and inserted into a lumen containing the lesion. The tissue patch then is positioned in the vicinity of the lesion. After removing the protective liner to reveal the tissue implant, the tissue implant is placed in the lesion.12-18-2008
20100145473Gradient Template for Angiogensis During Large Organ Regeneration - This invention relates to highly porous scaffolding and methods of producing the same. Specifically, the scaffolding comprises a pore volume fraction of no less than 80% (v/v) of the total volume of the scaffold and interconnecting pores forming channels in the scaffold.06-10-2010
20090030527AMORPHOUS METAL ALLOY MEDICAL DEVICES - This invention provides a new class of medical devices and implants comprising amorphous metal alloys. The medical devices and implants may be temporary or permanent and may comprise other materials as well, such as polymers, ceramics, and conventional crystalline or polycrystalline metal alloys.01-29-2009
20090030526COLLAGEN DEVICE AND METHOD OF PREPARING THE SAME - A laminated, bioimplantable dural graft product is configured for use as both an onlay graft and a suturable graft. The dural graft product is sufficiently pliable so as to sufficiently conform to a curvature of a tissue surface to which it is applied, such as the curved surface of a meningeal membrane. The use of the graft product can have improved properties, including suture retention strength and fluid impermeability. To use the dural graft product as an implant to replace, reinforce or strengthen bodily tissue, or to act as an adhesion barrier, the dural graft is placed in contact with bodily tissue and conforms to the curvature of the bodily tissue. Sutures can be used to maintain the contact between the dural graft and the bodily tissue.01-29-2009
20090138095Method for treating a cartilage defect, surgical instrumentation and surgical navigation system - The invention relates to a method for treating a cartilage defect by implanting a cartilage replacement implant through an arthroscopic access, comprising: determining at least one parameter for describing the arthroscopic access, providing a surgical instrumentation comprising at least two different applicator instruments for grasping the cartilage replacement implant, choosing one of the at least two applicator instruments of the instrumentation in dependence upon the at least one parameter determined for describing the arthroscopic access, and grasping and inserting the cartilage replacement implant into the patient's body with the chosen instrument through the arthroscopic access.05-28-2009
20090187258Implant for Tissue Engineering - The present invention relates to uses of resorbable medical implants that are metallic or semi-metallic, to produce soft tissues, membranous tissues, organs or organ parts within the body by fibrosis. The present invention further relates to such uses when the implants are made of specified alloys or metals, e.g. magnesium and its alloys. The present invention further relates to such uses when the implant is surface modified. The present invention further relates to such uses when the implant is pre-implanted at another part of the body before implantation into the target site.07-23-2009
20080306610TISSUE PROCESSING FOR NONIMMUNOGENIC IMPLANTS - Methods for processing tissues to render them suitable for implantation, e.g. in an orthopedic site. Tissues are rendered substantially acellular and substantially nonimmunogenic by exposure to processes that result in cell lysis, increasing permeability of the extracellular matrix, degrading the debris from lysis, and removing the debris. Methods of forming tissue implants, kits for processing tissue implants, and methods of using tissue implants are also disclosed.12-11-2008
20110224801SEMI-PERMEABLE MEMBRANES FOR USE IN SURGICAL REPAIRS - A semi-permeable membrane can be used to promote the surgical repair of cartilage in a damaged or diseased joint, such as a knee, hip, or shoulder. In one method, the semi-permeable membrane is secured to the “articulating” surface (the exposed surface, as opposed to the “anchoring” surface which rests on a condyle) of a resorbable fibrous matrix that has been seeded, before implantation, with chondrocyte or similar cells that generate cartilage. A membrane used in this manner can help protect the cells as they grow, reproduce, and secrete new cartilage inside the resorbable matrix. In another method, the semi-permeable membrane is secured to a slightly damaged surface of a cartilage segment that is suffering from a condition known as chondromalacia, without using an underlying implanted matrix or other device. In a slightly different use, a semi-permeable membrane as disclosed herein can be used in conjunction with a cell-growing scaffold that is being used to generate tissue to repair or supplement an internal organ, such as a liver, spleen, pancreas, or possibly a heart09-15-2011
20090024225Implant for Targeting Therapeutic Procedure - An implantable device has a body that is substantially rigid and has a predetermined shape. The body is further bioabsorbable and has a density less than or equal to about 1.03 g/cc. When the device is implanted in a resected cavity in soft tissue, it causes the cavity to conform to the predetermined shape. The implantable device is further imageable due to its density being less than that of soft tissue such that the boundaries of the tissue corresponding to the predetermined shape can be determined.01-22-2009
20090024227METHODS OF FORMING A MULTILAYER TISSUE IMPLANT TO CREATE AN ACCORDION EFFECT ON THE OUTER LAYER - Disclosed are implantable tissue augmentation devices, methods, and associated tools. The devices include an inflatable body, having an inner layer and an outer layer. A valve is provided for permitting the introduction of and retaining inflation media. At least one pull tab is provided on an end of the implant, to assist in positioning the implant. Kits and systems are also disclosed.01-22-2009
20090024226METHODS OF FORMING A TISSUE IMPLANT HAVING A TISSUE CONTACTING LAYER HELD UNDER COMPRESSION - Disclosed are implantable tissue augmentation devices, methods, and associated tools. The devices include an inflatable body, having an inner layer and an outer layer. A valve is provided for permitting the introduction of and retaining inflation media. At least one pull tab is provided on an end of the implant, to assist in positioning the implant. Kits and systems are also disclosed.01-22-2009
20090024224Implantation of cartilage - The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue by creating a first bore down to the bone portion of the cartilage defect, creating a second shaped bore that is concentric to and on top of the first bore to match the shape and size of the cartilage graft, treating the first bore and the second shaped bore at the defect site with a bonding agent, treating the circumferential area of the cartilage graft with a bonding agent, inserting the cartilage graft into the defect site and wherein the superficial surface of the cartilage graft is at the same height as the surrounding cartilage surface. The first and second bonding agents may be activated by applying a stimulation agent to induce sealing, integration, and restoration of the hydrodynamic environments of the recipient tissue. The invention is also directed towards a process for repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, cleaning and disinfecting the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps. The invention is further directed toward a repaired cartilage defect.01-22-2009
20090024228TISSUE IMPLANT HAVING A BIASED LAYER AND COMPLIANCE THAT SIMULATES TISSUE - Disclosed are implantable tissue augmentation devices, methods, and associated tools. The devices include an inflatable body, having an inner layer and an outer layer. A valve is provided for permitting the introduction of and retaining inflation media. At least one pull tab is provided on an end of the implant, to assist in positioning the implant. Kits and systems are also disclosed.01-22-2009
20110144767DEVICES AND METHODS FOR TREATING DEFECTS IN THE TISSUE OF A LIVING BEING - An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may include, or have blended in, an additive, such as an osteoinductive factor, for example biocompatible ceramics and glass.06-16-2011
20090054995Planar implant - A planar implant for replacement of biological tissues includes a layered structure including 02-26-2009
20090099666Spongy implant - The invention relates to the use of a spongy material for the production of an implant (04-16-2009
20120078379CELLULAR CONTROL AND TISSUE REGENERATION SYSTEMS AND METHODS - A system for in-vivo and ex-vivo tissue regeneration and cellular control, manipulation and management includes a source of cell manipulating factors, which are administered to a therapy zone via active pressure-differential components including a pump and a controller, or pulse-waves generated passively. A plate comprising tissue or an inert, bio-compatible material is provided in the therapy zone in proximity to a fluid flow manifold and tissue scaffolding. A tissue regeneration and cellular control method includes the steps of providing a cell manipulation factor source, providing one or more factors to a therapy zone and forming a pressure wave with a mechanical component or an in-vivo pressure wave source, such as the circulatory or lymphatic system.03-29-2012
20120078378PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME - Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.03-29-2012
20090204228EXTRACELLULAR MATRIX COMPOSITE MATERIALS, AND MANUFACTURE AND USE THEREOF - Described are preferred extracellular matrix composites including a first extracellular matrix material having a second extracellular matrix material deposited thereon. The preferred materials are made by culturing cells in contact with an extracellular matrix graft material in a fashion to cause the cells to biosynthesize and deposit extracellular matrix components on the material. The cells are then removed to provide the extracellular matrix composite material.08-13-2009
20090204227Molecular enhancement of extracellular matrix and methods of use - A composition comprising a human- or animal-derived extracellular matrix and a macromolecular network which is prepared ex vivo is provided that is useful in the repair of a tissue injury, particularly in repair of tears or gaps between a tendon and a bone, such as in a rotator cuff tear. In an embodiment, the composition comprises a human- or animal-derived extracellular matrix having impregnated therein a macromolecular network of hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages, so that the cross-linked network is interlocked within the extracellular matrix. The resulting HA-incorporated extracellular matrix can be supplied in the form of a patch to reinforce a tissue repair or cover a tissue defect.08-13-2009
20080275569Tissue Augmentation Device - A medical device and methods for filling tissue are disclosed. The device has a first configuration for delivery into tissue to be filled and a second configuration in which the device either expands, or is forced to expand within the tissue to be filled. The exterior profile of the expanded device may be customized along its length, to achieve a desired result. The device is adapted to be placed in the skin, and may be used to reduce facial wrinkles or augment facial features such as the lips.11-06-2008
20120035744AMNION AND CHORION CONSTRUCTS AND USES THEREOF IN JOINT REPAIR - A construct for use in a surgical repair of a damaged or inflamed joint is described. The construct contains an allograft having at least one layer of human amnion and chorion tissues, and is adapted for enclosing a damaged or inflamed joint or for covering or replacing a damaged or inflamed joint sheath during the surgical repair. Methods of preparing the construct and using it in a surgical repair of a damaged or inflamed joint are also described. The products and methods improve the performance of the joint surgery, e.g., by reducing inflammation, inhibiting fibrosis, scarring, fibroblast proliferation and post-operative infection while also promoting more rapid healing of damaged or traumatized joints.02-09-2012
20120197414NERVE GRAFT - A nerve graft includes a carbon nanotube structure, a hydrophilic layer, and a nerve network. The hydrophilic layer having a polar surface is located on a surface of the carbon nanotube structure. The nerve network positioned on the polar surface of the hydrophilic layer includes a number of neurons connecting with each other. The nerve network has a polarity. The polar surface of the hydrophilic layer has a polarity attracted to the polarity of the nerve network.08-02-2012
20130190893ELONGATED TISSUE MATRICES - Elongated and high aspect ratio tissue treatment products are provided. Methods of making and using the tissue treatment products are also provided. The tissue treatment products can be used as implants that conform to the site of implantation and resist migration away from their implantation site in viva07-25-2013
20120245705METHODS AND DEVICES FOR CELLULAR TRANSPLANTATION - Devices and methods for transplanting cells in a host body are described. The cell comprises a porous scaffold that allows ingrowth of vascular and connective tissues, a plug or plug system configured for placement within the porous scaffold, and a seal configured to enclose a proximal opening in the porous scaffold. The device may further comprise a cell delivery device for delivering cells into the porous scaffold. The method of cell transplantation comprises a two step process. The device is incubated in the host body to form a vascularized collagen matrix around a plug positioned within the porous scaffold. The plug is then retracted from the porous scaffold, and cells are delivered into the vascularized space created within the porous scaffold.09-27-2012
20100228359IMPLANT OF CROSS-LINKED SPIDER SILK THREADS - The present invention provides the use of spider silk threads for the production of tissue implants for medical use. A scaffolding matrix is provided for implantation, which matrix is comprised of spider silk thread and/or segments of spider silk threads which are cross-linked. The cross-linked spider silk thread segments essentially maintain a three-dimensional shape into which it is formed by pressing between moulds. The three-dimensional shape obtainable by moulding is sufficiently stable to be used as an implant or for colonizing by mammalian cells while essentially maintaining the three-dimensional shape. In a further embodiment, the scaffolding matrix of cross-linked spider silk segments is at least partially covered by cells autologous or heterologous to the implant recipient. The matrix colonized with cells is obtainable by in vitro cultivation of isolated cells in suspension with the scaffolding matrix.09-09-2010
20130123938STITCHABLE TISSUE TRANSPLANT CONSTRUCT FOR THE RECONSTRUCTION OF A HUMAN OR ANIMAL ORGAN - The invention relates to a tissue transplant construct for the reconstruction of a human or animal organ. The tissue transplant construct (05-16-2013
20110112655DEVICE FOR REGENERATION OF ARTICULAR CARTILAGE AND OTHER TISSUE - An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. A preferred embodiment includes a cartilage region comprising a polyelectrolytic complex joined with a subchondral bone region. The cartilage region, of this embodiment, enhances the environment for chondrocytes to grow articular cartilage; while the subchondral bone region enhances the environment for cells which migrate into that region's macrostructure and which differentiate into osteoblasts. A hydrophobic barrier exists between the regions, of this embodiment. In one embodiment, the polyelectrolytic complex transforms to hydrogel, following the implant procedure.05-12-2011
20130218293MEDICAL INSTRUMENT - A medical instrument includes a handpiece, a tank portion configured to house a fluid, a suction/discharge unit configured to change a volume or pressure of an inside of the tank portion to suction the fluid into the tank portion or discharge the fluid from the tank portion, and an operating unit providing a member different from the suction/discharge unit and configured to operate the suction/discharge unit.08-22-2013
20130218294Plasticized Bone and Soft Tissue Grafts and Methods of Making and Using Same - The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.08-22-2013
20120143349BARBED SCAFFOLDS - A scaffold for tissue reinforcement according to embodiments of the present invention includes a plurality of barbs configured to engage the tissue. Such scaffolds may include braids with barbed fibers in the axial positions, braids with flexible barb strips in the axial positions, weaves with barbed fiber in the warp positions, weaves with flexible barb strips in the weft positions, and cerclages or other structures with barbs on one surface to lock the scaffold upon itself. Such barbs may be configured to substantially prevent sliding in one or more directions, depending upon an orientation of the barbs. Flexible tack strips may be biocompatible and/or resorbable.06-07-2012
20080288085VIVO SYNTHESIS OF CONNECTIVE TISSUES - The in vivo synthesis of connective tissue by fibroblast or fibroblast precursor cells ensconced within a biocompatible scaffold is disclosed. The cells are preferably present in a biocompatible scaffold such as gelatin and placed between two other biocompatible scaffolds such as collagen sponges soaked with a collagenic amount of a member of the TGF-β family of proteins. This composition is then implanted in a host to produce cranial sutures, periodontal ligament or other fibrous tissue structures in vivo.11-20-2008
20100312357DEVICE AND METHOD FOR DEPLOYING AND ATTACHING AN IMPLANT TO A BIOLOGICAL TISSUE - This present invention generally relates to devices and methods for repairing an aperture in a biological tissue. In certain embodiments, the invention provides a system for closing an aperture in a biological tissue including a handle, an elongate shaft connected to the handle, and a deployment scaffold connected to the shaft, in which the scaffold is configured to releasably retain a surgical implant and the scaffold is configured to deploy and attach the surgical implant to the biological tissue.12-09-2010
20130144400SCAFFOLD FOR BONE AND TISSUE REPAIR IN MAMMALS - A mammalian tissue scaffold and method for making a tissue scaffold including a rigid scaffold body of biocompatible glass fibers bonded together and in special alignment to define open channels within the scaffold to allow fluid flow into and within the scaffold.06-06-2013
20110245929METHODS AND COMPOSITIONS FOR JOINT HEALING AND REPAIR - The invention in some aspects provides implantable articles comprising in vitro-prepared tissues for joint repair. Devices and methods for introducing implantable articles into a subject are also provided. In some aspects of the invention devices and systems for minimally invasive surgery are provided. In some aspects, methods are provided for regenerating a bone-tendon interface in a subject by implanting an in vitro-prepared tissue between a detached tendon or detached ligament and a bone in a subject. In other aspects, methods are provided for maintaining exogenous, viable fibroblasts between a detached tendon and a bone in a subject. In other aspects, methods are provided for delivering exogenous cytokines and/or growth factors to a damaged bone-tendon interface.10-06-2011
20090069903Method For Improvement Of Differentiation Of Mesenchymal Stem Cells Using A Double-Structured Tissue Implant - A double-structured tissue implant (DSTI) and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant for differentiation, growth and transformation of cells, stem cells, mesenchymal stem cells and bone marrow stem cells. DSTI comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold.03-12-2009
20100114328RESORBABLE MEMBRANE IMPLANTING METHODS FOR REDUCING ADHESIONS - A resorbable thin membrane is applied over a treatment site before a treatment is applied over the resorbable thin membrane to the site. In a particular implementation, a resorbable thin membrane is adhesively applied over a treatment site of tissue before a treatment is conducted onto the tissue whereby the treatment is performed through the resorbable thin membrane. The treatment can be an incision that is made through both the resorbable membrane and into or through the tissue.05-06-2010
20110082565NONWOVEN STRUCTURE AND METHOD OF FABRICATING THE SAME - A method for fabricating a nonwoven structure is disclosed. The method comprises: forming a nonwoven layer of polymer fibers on the collector liquid surface, transferring the layer to a solid surface, and repeating the formation and the transfer in a layerwise manner. The method is generally effected by spinning liquefied polymer, in particular by employing electrostatic or hydrostatic forces. The nonwoven structure formed comprises of plurality of nonwoven layers: the average thickness of the nonwoven structure is at least 0.5 mm and the structure has an overall porosity of at least 90%. The nonwoven structure an be used in forming a scaffold for tissue engineering, in particular a cell-scaffold composition, suitable for implanting in a patient, wherein at least one cell population is seeded on at least one of the plurality of layers.04-07-2011
20110082564Devices and Methods for Tissue Engineering - A tissue scaffold fabricated from bioinert fiber forms a rigid three-dimensional porous matrix having a bioinert composition. Porosity in the form of interconnected pore space is provided by the space between the bioinert fiber in the porous matrix. Strength of the porous matrix is provided by bioinert fiber fused and bonded into the rigid three-dimensional matrix having a specific pore size and pore size distribution. The tissue scaffold supports tissue in-growth to provide osteoconductivity as a tissue scaffold, used for the repair of damaged and/or diseased bone tissue.04-07-2011
20090312843Tissue Reconstruction Devices and Methods - The present invention provides an implantable prosthesis comprising a viscera separating barrier that defines a shell having a pocket with an opening that receives an insert. It is contemplated that the insert comprises at least one of an absorbable mesh, a non-absorbable mesh, or an absorbable and non-absorbable mesh combination inserted into the pocket through the opening. In preferred embodiments the viscera separating barrier is acellular collagen, and the absorbable mesh is selected from at least one of a polyglactin, a polyglycolic acid, a polyglactin and a polylactic acid, and the non-absorbable mesh comprises a polypropylene mesh. It is contemplated that the viscera separating barrier acts to reduce or even eliminate attachment of viscera to the prosthesis to encourage rapid cell penetration and revascularization; the non-absorbable mesh will provide immediate, reliable in-growth; and the absorbable mesh will give stability to the prosthesis.12-17-2009
20090312842Assembled Cartilage Repair Graft - Bifunctional and assembled implants are provided for osteochondral implantation.12-17-2009
20090216338SOFT TISSUE IMPLANTS AND METHODS FOR MAKING SAME - The present invention features soft tissue implants comprising major (08-27-2009
20100063600Materials and Methods for Soft Tissue Augmentation - The subject invention provides materials and methods for soft tissue augmentation. The materials and methods of the subject invention can, advantageously, be used to correct defects such as velopharyngeal insufficiency after cleft palate repair. Other uses include treatments for gastroesophageal acid-reflux, urinary incontinence, wrinkles and contour abnormalities.03-11-2010
20100063599DEVICE FOR SOFT TISSUE REPAIR OR REPLACEMENT - Disclosed are composite implantable tissue attachment devices comprising a mechanical reinforcing component and a cellular scaffold component. Disclosed devices include a wide, relatively flat portion for supporting long term repair of tissue. Disclosed devices can include a tapered portion at the end of the wide portions that can lead into a narrower elongated extension for aiding in placement of the device during a surgical procedure. The wide portion of the device can provide tensile strength along the longitudinal axis of the device as well as porosity. The wide devices can cover a larger surface area of a delivery site than standard suture. Disclosed materials can be utilized in, e.g., soft tissue repair such as tendon and ligament reconstruction and repair.03-11-2010
20110178608Implantable Repair Device - An implantable prosthesis for repairing or reinforcing a tissue or muscle wall defect including a first composite structure including at least one layer of a non-absorbable material, wherein the first composite structure has a central portion sized and shaped to cover at least a portion of the tissue or muscle wall defect, and has an outer periphery. The prosthesis further includes a second structure having a reinforced central region and an outer peripheral edge, a reinforcing element positioned between the first and second structures, and having an outer periphery and a stiffness greater than that of the first and second structures, and at least one pulling element coupled to the reinforced central region of the second structure. The second structure is coupled to the first structure substantially only at their respective peripheries.07-21-2011
20120035743AMNION AND CHORION CONSTRUCTS AND USES THEREOF IN MINIMALLY INVASIVE SURGERIES - A construct for use in a minimally invasive surgery is described. The construct contains an allograft having at least one layer of human amnion and chorion tissues, and is adapted for insertion into a small incision or a cannula employed in the minimally invasive surgery for access to the surgical site. The allograft has a shape appropriate for covering the surgical site. Methods of preparing the construct and using it in a minimally invasive surgery are also described. The products and methods improve the performance of the minimally invasive surgery, e.g., by reducing adhesions, scar formation while also reducing inflammation and risk of post-operative infection.02-09-2012
20100057218METHODS OF ADMINISTERING A MATERIAL INTO A PATIENT FOR DERMAL ENHANCEMENT - The present invention is directed to methods of administering a material to a patient for dermal enhancement and/or as soft tissue fillers. The invention also relates to double-gloved methods of molding such a material after administration to a patient to achieve a desired orientation of the material in the patient. The invention also relates to the use of certain materials, including polylactic acid, hyaluronic acid, hydrogel, and/or collagen or other suitable materials for the preparation of a pharmaceutical composition for dermal enhancement and/or as soft tissue filler. The invention further relates to kits or packages that include a material for dermal enhancement and/or soft tissue filler and instructions as to how dermal enhancement or the filling of soft tissue is achieved.03-04-2010
20110098826Disc-Like Angle-Ply Structures for Intervertebral Disc Tissue Engineering and Replacement - Provided are implant scaffolds comprising angle-ply arrays of two or more layers of substantially aligned fiber, methods of making and using said scaffolds, and kits comprising such scaffolds.04-28-2011
20120071988TISSUES PATCHES AND RELATED DELIVERY SYSTEMS AND METHODS - Endoluminally delivered tissue patches and related systems and methods for delivering the tissue patches for treating lesions of the alimentary tract are disclosed. A system for delivering a tissue implant includes a catheter having an expandable member at a distal end portion, a carrier placed around the expandable member, and the carrier configured to expand from a contracted state to an expanded state and to receive the tissue implant. The tissue implant contacts the lesion of the alimentary tract when the expandable member expands the carrier to the expandable state.03-22-2012
20110251699AUTO-SEALANT MATRIX FOR TISSUE REPAIR - Implants for tissue repair/regeneration include a porous layer combined with dry materials that are activated to form a hydrogel upon contact with aqueous physiological fluids.10-13-2011
20100168869Tissue integration implant - The present invention relates to a tissue defect repair implant including a porous material, wherein the material is expandable or compressible. The implant may be a scaffold, and may also be formed of a material such as, for example, collagen or demineralized bone matrix. Another aspect of the invention may be a method for the repair of a tissue defect in a patient in need thereof, including implanting an implant between two adjacent tissues, wherein the implant may include a porous material which is expandable or compressible. The two tissues may be soft tissue and hard tissue, and alternatively, the two tissues may be soft tissue, and may further be the same or different soft tissues.07-01-2010
20090143867Implants and Methods for Repair, Replacement and Treatment of Disease - Implants comprising cartilage and trabecular metal, and methods of making the implants are disclosed. Further disclosed are therapeutic uses of the implants, which include methods of treatment or repair of an chondral or osteochondral defect, such as a chondral or osteochondral injury, lesion or disease. An implant comprises cartilage or chondrocytes and a subchondral base comprising trabecular metal. An implant can comprise a geometric shape such as a cylinder or an anatomical shape such as a condyle, and can be used in conjunction with a positioning structure.06-04-2009
20090240343INFLATABLE HERNIA PATCH - A patch for repairing an intra-abdominal defect is disclosed in one embodiment of the present invention as including a mesh layer providing a grid of material perforated by apertures through the mesh. This mesh is used to reinforce an area around an intra-abdominal defect. A containment layer is secured proximate an edge of the mesh layer. A filler is distributed across the apertures of the mesh to contain a fluid from passing through the mesh. The mesh layer, containment layer, and filler are connected to form a chamber to selectively expand upon receipt of a quantity of fluid between the containment layer and the filler.09-24-2009
20090240342PREFORMED SUPPORT DEVICE AND METHOD AND APPARATUS FOR MANUFACTURING THE SAME - A device for making a seamless, anatomically contoured, prosthetic device for supporting or maintaining the position of mammalian tissue, organ or structure or a replacement thereof, such as a breast implant, includes a support plate, an ironing plate or a clamping plate and a core plate, each of which is made from a thermally conductive material. The support plate and the ironing or clamping plates have openings formed through the thickness thereof. The core plate has a core extending outwardly from a lower surface thereof which is received through the openings in the ironing or clamping plate and the support plate.09-24-2009
20110257762PROSTHETIC IMPLANT WITH A DELAYED BONDING EFFECT - The invention relates to a prosthetic system (10-20-2011
20110257763Method for Bone-filling Cartilage Tissue for Inducing Regeneration of the Cartilage - It is intended to provide a medical material which enables a new method for cartilage tissue regeneration treatment based on an entirely new concept unlike a treatment method by transplantation of autologous cartilage tissue, a cartilage alternative or undifferentiated cells. The invention provides a bone filler for cartilage tissue regeneration comprising hydrogel having an interpenetrating network structure formed by two or more crosslinked network polymers or a semi-interpenetrating network structure formed by a crosslinked network polymer and a linear polymer. By filling the bone filler of the invention in a hole or a groove provided in subchondral bone just under damaged cartilage tissue, regeneration of the cartilage tissue or both the cartilage tissue and the subchondral bone can be promoted.10-20-2011
20110257761PROSTHETIC DEVICE HAVING REGIONS OF VARYING STRETCH AND METHOD OF MANUFACTURING THE SAME - A biocompatible surgical scaffold made from a multi-filament silk yarn for soft tissue reconstruction. The scaffold incorporates regions of varying stretch having different physical and mechanical properties that allow contouring to the required soft tissue shape to be replaced or repaired. The porous structure allows tissue in-growth, while the mesh degrades at a rate which allows for a smooth transfer of mechanical properties to the new tissue from the silk scaffold.10-20-2011
20080281433METHODS AND DEVICES TO CREATE A CHEMICALLY AND/OR MECHANICALLY LOCALIZED PLEURODESIS - A localized pleurodesis for lung devices created utilizing a combination of a mechanical component and a chemical component. The chemical component is utilized to create an acute adhesion between the visceral pleural membrane and parietal pleural membrane while the mechanical component is utilized to create a chronic adhesion.11-13-2008
20110060420PTFE COMPOSITE MULTI-LAYER MATERIAL - A composite multi-layer material may generally comprise a d-PTFE material combined with an open structured material (either resorbable or non-resorbable) creating a composite multi-layer material. Attachment of the layers may be accomplished by stitching layers of material, exertion of hydraulic or other pressure, application of a biocompatible adhesive or heat, or some combination of the foregoing. Use of a d-PTFE, unexpanded material has multiple alternative uses, including without limitation, placement on the visceral side of a hernia that may minimize or even eliminate the incidence of abdominal adhesions. Alternatively, the material may be used to create tubing sufficient as a graft for treating abdominal aortic aneurysms.03-10-2011
20100179667SCAFFOLD FOR BONE AND TISSUE REPAIR IN MAMMALS - A mammalian tissue scaffold and method for making a tissue scaffold including a rigid scaffold body of biocompatible glass fibers bonded together and in special alignment to define open channels within the scaffold to allow fluid flow into and within the scaffold.07-15-2010
20100217403SWELLABLE HYALURONIC ACID PARTICLES - The present invention generally relates to particles comprising hyaluronic acid, wherein the particles are coated or encapsulated with a coating. The coating preferably comprises a polymer, protein, polysaccharide, or combination thereof that decreases the rate of degradation of the hyaluronic acid once the particles are placed in an aqueous environment, such as inside mammalian skin. The compositions of the present invention comprising such coated hyaluronic acid are useful for soft tissue augmentation, and are particularly useful as dermal fillers.08-26-2010
20100082113TISSUE REPAIR IMPLANT - Described herein are tissue repair implants that include a first or lower layer of peritoneal membrane and a support member. The implants can further include an upper layer of peritoneal membrane, and the support member can reinforce the two layers of peritoneal membrane. For example, the support member can be located between the lower layer of peritoneal membrane and the upper layer of peritoneal membrane. The support member can be encapsulated between the two layers of peritoneal membrane to attach the two layers of peritoneal membrane to the support member. The support member can be made from a non-biological synthetic material mesh with a plurality of openings extending therethrough. Either of the layers of peritoneal membrane and/or the support member may be attached to a wall (e.g., an interior wall) of an abdominal tissue. Either of the layers of peritoneal membrane may be remodelled by in-growth of tissue.04-01-2010
20120150317NERVE GRAFT - A nerve graft includes a carbon nanotube film structure, a protein layer, and a nerve network. The protein layer is located on a surface of the carbon nanotube film structure. The nerve network is positioned on a surface of the protein layer and far away from the carbon nanotube film structure.06-14-2012
20100030340Plasticized Grafts and Methods of Making and Using Same - The invention provides a plasticized tissue or organ that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in natural tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the plasticized bone or soft tissue product can be placed directly into an implant site without significant preparation in the operating room.02-04-2010
20100023132SYSTEM AND METHOD FOR SCAFFOLDING ANASTOMOSES - Embodiments of the invention provide systems and methods for using a tissue scaffold to facilitate healing of an anastomosis. One embodiment provides a tissue scaffold for placement at an anastomotic site within a body lumen comprising a radially expandable scaffold structure having lateral and mid portions, at least one retention element coupled to each lateral portion and a barrier layer. The retention element engages a luminal wall when the scaffold structure is expanded to retain the structure and exert a compressive force on the anastomosis. The mid portion has a greater radial stiffness than the lateral portions such that when the structure is expanded, the lateral portions engage tissue prior to the mid portion. The barrier layer is configured to engage a luminal wall when the structure is expanded to provide a fluidic seal at the anastomosis. The barrier layer may also include releasable biological agents to promote anastomotic healing.01-28-2010
20110218647MEDICAL IMPLANT - A cartilage plug (09-08-2011
20100016989METAL OXIDE SCAFFOLDS - The present invention relates to a metal oxide scaffold comprising titanium oxide. The scaffolds of the invention are useful for implantation into a subject for tissue regeneration and for providing a framework for cell growth and stabilization to the regenerating tissue. The invention also relates to methods for producing such metal oxide scaffolds and their uses.01-21-2010
20110054633Nanofilm Protective and Release Matrices - A modified atomic plasma deposition (APD) procedure is used to produce amorphous, nonconformal thin metal film coatings on a variety of substrates. The films are porous, mesh-like lattices with imperfections such as pinholes and pores, which are useful as scaffolds for cell attachment, controlled release of bioactive agents and protective coatings.03-03-2011
20090287313TISSUE ADHESIVE SEALANT - A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.11-19-2009
20090069904BIOMATERIAL INCLUDING MICROPORES - A biomaterial including a designed pattern of micropores one at least one surface of the biomaterial is described. The micropores can be provided in a regular or irregular pattern, and can be either continuous or discontinuous. The biomaterial may be formed from a variety of materials, such as a biocompatible polymer or biocompatible tissue. The biomaterial including micropores on a surface may be used for a variety of medical applications such as tissue scaffolding, drug delivery, or tissue fixation.03-12-2009
20110307077COMPOSITE ANISOTROPIC TISSUE REINFORCING IMPLANTS HAVING ALIGNMENT MARKERS AND METHODS OF MANUFACTURING SAME - A composite implant includes an anisotropic surgical mesh having more stretchability along a first axis and less stretchability along a second axis that traverses the first axis, and an alignment marker overlying a first major surface of the anisotropic mesh and extending along the first axis. The implant includes a first absorbable, anti-adhesion film overlying the alignment marker and the first major surface of the anisotropic mesh, and a second absorbable, anti-adhesion film overlying the second major surface of the biocompatible mesh. The alignment marker is disposed between the first and second absorbable films and the first and second absorbable films are laminated to the anisotropic mesh.12-15-2011
20080208358Nanofilament Scaffold for Tissue Regeneration - A scaffold for tissue regeneration is provided. In a preferred embodiment, the scaffold is implantable in a patient in need of nerve or other tissue regeneration and includes a structure which has a plurality of uniaxially oriented nanofibers made of at least one synthetic polymer. Preferably, at least 75% of the nanofibers are oriented within 20 degrees of the uniaxial orientation. The scaffold beneficially provides directional cues for cell and tissue regeneration, presumably by mimicking the natural strategy using filamentous structures during development and regeneration.08-28-2008
20090054994Methods and kits for prophylactically reinforcing degenerated spinal discs and facet joints near a surgically treated spinal section - A method is effective for prophylactically treating discs and facet joints near a spinal section that requires surgery. The method comprises the steps of performing a surgical procedure on a section of a spine, and reinforcing a disc or a facet joint adjacent to the surgically treated area with an effective amount of an injected, in situ curable biocompatible matrix or biocompatible polymeric compound. The procedure delays or prevents the development of permanent or irreversible degenerative changes in the treated disc and/or facet joint, thus offering the spinal surgery patient a higher probability of long-term success for arresting disc and facet joint degeneration and prevention of latent adjacent disc/facet joint problems.02-26-2009
20120310367ADIPOSE TISSUE MATRICES - The present disclosure provides tissue products produced from adipose tissues, as well as methods for producing such tissue products. The tissue products can include acellular extracellular matrices. In addition, the present disclosure provides systems and methods for using such products.12-06-2012
20080300691Biomimetic Synthetic Nerve Implant Casting Device - A biomimetic biosynthetic nerve implant (BNI) casting device includes a matrix casting tube; a matrix casting tube protective shield comprising a male coupling portion joinable to a female coupling portion, wherein the joined portions encase the matrix casting tube; microchannel forming fibers; a fixing point for holding one end of the microchannel forming fibers; loading fiber guideholes for placement of the microchannel forming fibers; one or more ports for injection of matrix material into the casting tube; and a cell suspension loading well in fluid communication with the matrix casting tube when the device is fully assembled such that removing the fibers from the formed implant can draw fluid containing cells and/or other agents into the microchannels.12-04-2008
20120209403VASCULARIZED TISSUE GRAFT - The present invention relates to improved methods for tissue engineering including tissue transplantation, augmentation and regeneration, and more particularly, a method for the generation of donor vascularized tissue suitable for use in tissue transplantation, augmentation and/or repair. The present invention enables the use of a support matrix in the generation of an anatomical construct comprising the donor vascular tissue. The support matrix may be devised such that it has dimensions of a size and shape adapted to simulate those of tissue to be transplanted, augmented and/or repaired. The methods and support matrix of the present invention may also find application as a means for delivering a desirable gene product to a subject. The method and support matrix of the present invention is conveniently made available in the form of a kit, for use in the field of tissue engineering.08-16-2012
20120010725Tissue Implants for Implantation and Methods for Preparing the Same - A method is provided for preparing a tissue implant for implantation. The method includes treating a pericardium tissue material, which has been harvested from a donor and rendered essentially acellular, with a chlorine dioxide treatment solution; and thereafter treating the pericardium tissue material with an antioxidant solution, which comprises ascorbic acid or a salt thereof.01-12-2012
20120209402Implant for Tissue Engineering - The present invention relates to uses of resorbable medical implants that are metallic or semi-metallic, to produce soft tissues, membranous tissues, organs or organ parts within the body by fibrosis. The present invention further relates to such uses when the implants are made of specified alloys or metals, e.g. magnesium and its alloys. The present invention further relates to such uses when the implant is surface modified. The present invention further relates to such uses when the implant is pre-implanted at another part of the body before implantation into the target site.08-16-2012
20120209401METHODS AND APPARATUS FOR DELIVERING AND POSITIONING SHEET-LIKE MATERIALS - An implant delivery system for delivering a sheet-like implant is disclosed. The device includes an implant spreader assembly disposed proximate the distal end of a delivery shaft. The implant spreader assembly includes a first arm and a second arm. The arms are coupled to the delivery shaft such that the first arm and second arm are moveable between a closed position and an open position. When the first and second arms are in the closed position, the arms extend generally in the longitudinal direction. When pivoting to the open position the distal end of each arm travels in a generally transverse direction to spread a sheet-like implant.08-16-2012
20120010728METHOD FOR SHAPING TISSUE MATRICES - Methods for shaping tissue matrices are provided. The methods can be used to produce shaped tissue products that retain desired biologic properties without using chemical crosslinking agents.01-12-2012
20120010727AMNION AND CHORION CONSTRUCTS AND USES THEREOF IN SPORT INJURY SURGERIES - Improved methods for sport injury surgeries are described. The improvement includes covering a damaged site of fascia with at least one of an amniotic fluid and a construct for use in surgical repair of the sport injury prior to wound closing. The construct contains an allograft comprising at least one layer of human amnion and chorion tissues and the construct has a size and shape suitable for covering the damaged site of fascia. The method improves fascial membrane repair, reduces complications and recovery time of sport injury surgeries.01-12-2012
20110166673QUILTED IMPLANTABLE GRAFT - Described are embodiments of a multilaminate or multiple layer implantable surgical graft with an illustrative graft comprising a remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.07-07-2011
20120065741GUIDED TISSUE REGENERATION MEMBRANE - A guided tissue regeneration membrane has a top surface, a bottom surface and a plurality of through holes formed through the top and bottom surfaces. Each of the plurality of through holes has a base opening on the top surface and a tip opening on the bottom surface. The diameter of the base opening is larger than that of the tip opening. The guided tissue regeneration membrane is placed between a hard tissue and a soft tissue of gums with the top surface thereof facing the hard tissue so as to hinder the soft tissue from rapidly growing. The tip openings are available for the soft tissue to supply nutrient to the hard tissue therethrough. The hard tissue can grow from the base openings, through the corresponding through holes and to the soft tissue to repair periodontal tissue.03-15-2012
20120016491LAMINATE SHEET ARTICLES FOR TISSUE REGENERATION - The invention is to articles of extracellular matrix. The articles comprise one or more sheets of mammalian extracellular matrix laminated together. A single sheet can be folded over and laminated on 3 sides. Two or more sheets can be laminated to each other at their edges. The sheets can further encase a composition comprising a cell or cells, such as for example, a stem cell. A single sheet can be folded over to encase a composition, or rolled to encase a composition with lamination at either end of the roll, for example. The invention also includes methods of using these articles to regenerate tissue at tissue defects, or heal wounds in damaged tissue.01-19-2012
20120059488TRANSPLANTATION DEVICE - The present invention is intended to provide a transplantation device which can transplant a graft into a layered tissue easily and without damaging the graft or a tissue around the transplantation site. A transplantation device (03-08-2012
20120059487BIOMATERIALS WITH ENHANCED PROPERTIES AND DEVICES MADE THEREFROM - Biomaterials with enhanced properties such as improved strength, flexibility, durability and reduced thickness are useful in the fabrication of biomedical devices, particularly those subjected to continuous or non-continuous loads where repeated flexibility and long-term durability are required. These enhanced properties can be attributed to elevated levels of elastin, altered collagen types, and other biochemical changes which contribute to these enhanced properties. Examples of devices which would be improved by use of such tissue include heart valves, including percutaneous heart valves, and vascular grafts, patches and the like. Such enhanced materials can be sourced from specific populations of animals, such as neonatal calves, or in range-fed adult cattle, or can be fabricated or created from cell populations exhibiting such properties. In one embodiment, glutaraldehyde-fixed neonatal pericardial tissue is used to create leaflets in a percutaneous heart valve, and may be used without chemical fixation, with or without processes to remove residual cellular membranes, and utilized as a scaffold material for tissue engineering.03-08-2012
20110093088SELF DEPLOYING IMPLANT IN NEEDLE - Described, in certain inventive embodiments, are unique devices and methods for introducing implants into soft tissue of a patient. One of these devices includes a tissue-penetrating member that is configured to pass in its entirety through a volume of patient tissue. The tissue-penetrating member has a leading end and a trailing end, and provides a receiving space for receipt of an implant body portion for carrying the implant body portion into the volume of patient tissue. The device also includes an implant that has an implant body portion removably received in the receiving space of the tissue-penetrating member. The implant body portion is configured for deployment from the receiving space in the volume of patient tissue so as to remain deployed there along a passageway traversed by the tissue-penetrating member.04-21-2011
20110035025OSTEOCHONDRAL IMPLANT PROCEDURE - A surgical procedure for preparing a damaged area of a human knee to receive at least one graft, according to which a moldable material is positioned over the damaged area and removed after it hardens. The mold is used as a template to determine the number and/or a dimension of the openings to be formed in the damaged area for receiving corresponding grafts.02-10-2011
20110035024Self-Supporting Collagen Tunnel for Guided Tissue Regeneration and Method of Using Same - A biocompatible, self-supporting, curved, collagen membrane adapted to be secured by bone tacks or bone screws over exposed bone at a desired bone graft site in the alveolar ridge of a patient such that the membrane defines a space having a predetermined height and width over the exposed bone, in which the membrane maintains its structural integrity for at least 4 months after implantation at the bone graft site and then naturally breaks down and is resorbed by the patient's body, a method of making such a membrane, and a method of using such a membrane for vertical augmentation of the alveolar ridge of the patient.02-10-2011
20120123557DOUBLE CROSS-LINKAGE PROCESS TO ENHANCE POST-IMPLANTATION BIOPROSTHETIC TISSUE DURABILITY - Bioprosthetic tissues and methods for making same, comprising fixing bioprosthetic implant tissue by treatment with 0.1 to 10 wt. % glutaraldehyde at elevated temperature, capping said fixed tissue by treatment with a diamine crosslinking agent, and treating said capped tissue with about 0.6 wt. % glutaraldehyde.05-17-2012
20090069902ARTIFICIAL CONTRACTILE TISSUE - Artificial contractile tissue including a structure (b,f) and several fibers (a,g) of variable length which are fixed at their ends to the structure (b,f). The fibers (a,g) are made of a contractile material which can be activated by an activator in such a way as to provide a tissue in a rest or in an activated position, the rest position being defined with non-rectilinear fibers (a,g) and the activated position being defined with fibers (a,g) of reduced length; the transition from the rest towards the activated position or vice-versa being defined by a fiber movement along a lateral direction which is perpendicular with respect to the fiber length.03-12-2009
20100249946TRANSCUTANEOUSLY ADJUSTABLE FLUID-FILLED IMPLANTS - Disclosed are implantable tissue augmentation devices, methods, and associated tools. The devices include an inflatable body, having a self-sealing membrane operably attached to a wall of the implant. The self-sealing membrane provides access for filling the device, and includes a first layer comprising a fabric. The fabric has a first plurality of yarn strands positioned in a first direction, and a second plurality of yarn strands positioned in a second direction. The first and second plurality of yarn strands intersect to form a matrix pattern with cells defined by free spaces between yarn strands. The membrane also includes a first elastomeric material configured to fill the cells as well as form a coating over the first and second plurality of yarn strand, and a second layer comprising a second elastomeric material. The second elastomeric material has a lower durometer than the first elastomeric material. Kits and systems are also disclosed.09-30-2010
20120083900MULTI-LAYER TISSUE SYSTEMS AND METHODS - Embodiments of the present invention encompass anti-adhesion wound dressings including patches made from amnion tissue obtained from human birth tissue. Exemplary amnion patches can be fabricated by folding a section of amnion over on itself with the epithelial layer on the outside of the folded patch and the fibroblast layer on the inside of the folded patch. Optionally, individual amnion tissue pieces can be sandwiched together to provide a multi-layer patch. Sufficient pressure is applied to the layered amnion to cause adherence between opposing faces of the fibroblast layers. The pressed fibroblast layers provide mechanical strength to hold the amnion patch together with the epithelial layers on the outsides of the amnion patch.04-05-2012
20120165957BIODEGRADABLE SCAFFOLD FOR SOFT TISSUE REGENERATION AND USE THEREOF - The present invention relates to new reinforced biodegradable scaffolds for soft tissue regeneration, as well as methods for support and for augmentation and regeneration of living tissue, wherein a reinforced biodegradable scaffold is used for the treatment of indications, where increased strength and stability is required besides the need for regeneration of living tissue within a patient. The present invention further relates to the use of scaffolds together with cells or tissue explants for soft tissue regeneration, such as in the treatment of a medical prolapse, such as rectal or pelvic organ prolapse, or hernia.06-28-2012
20120215322ARTIFICIAL DURA BIOMEDICAL DEVICE AND BRAIN SURGERY METHOD UTILIZING THE SAME - An artificial dura biomedical device and a brain surgery method utilizing the same are disclosed. The steps includes: fixing an artificial dura to a partial skull; and fixing the partial skull with the artificial dura to a cut hole of a whole skull. The artificial dura biomedical device includes an artificial dura and a connecting element. The connecting element fixes the partial skull with the artificial dura.08-23-2012
20100204803ARTIFICIAL CONTRACTILE STRUCTURE AND APPARATUS COMPRISING SUCH STRUCTURE - An artificial contractile structure generally devised to be used in the medical field to assist the functioning of an organ, includes a support (08-12-2010
20110184531OPEN CELLED FOAMS, IMPLANTS INCLUDING THEM AND PROCESSES FOR MAKING SAME - Described herein are open celled foams including a matrix of interconnected spheres. Also described herein are methods of making open celled foams as well as making composite members with open celled foam coatings covering at least a portion of the composite member. The open celled foams described herein are silicone based materials and can be used to coat implants such as breast implants and function to encourage tissue ingrowth and reduce capsular formation.07-28-2011
20120221118MATERIALS FOR SOFT AND HARD TISSUE REPAIR - Biomaterials and methods and uses for repair or augmentation of tissues are provided. In particular, the invention provides a multi-layered, naturally occurring multi-axial oriented biomaterial comprising predominately type I collagen fibers. The invention further provides methods and uses for repair or augmentation of tissues using biomaterials of the invention.08-30-2012
20120259428Soft Tissue Implant and Method of Using Same - A soft tissue implant for correction of temporalis depressions or hollowing. The implant has a symmetric shape or external configuration, so that the device may be used as either a right or left temporalis implant. The implant may lie under or on top of the remaining temporalis muscle, or in the location formerly occupied by the temporalis muscle, to correct post-craniectomy temporal hollowing. The implant is manufactured from a medical grade, long term implantable silicone polymer material. The implant has a shell which forms the base of the device, with the base having an exterior surface and an interior surface with spaced projecting support structures. The implant is fully flexible or bendable.10-11-2012
20100298953DEVICE AND METHOD FOR POSITIONING A SURGICAL PROSTHESIS - In one aspect, the present invention relates to a medical device for positioning a surgical prosthesis on a fascial defect of a tissue wall. In one embodiment, the medical device has a removable flexible member having a body portion having at least one magnetic section, and a magnet member positioned in relation to the at least one magnetic section such that a movement of the magnet member causes the flexible member to move accordingly. The surgical prosthesis is detachably attachable to the flexible member, and the flexible member is introducible into and removable from a body cavity.11-25-2010
20120179271Devices and Methods for Tissue Engineering - A tissue engineering scaffold of interconnected and bonded fiber having a property with a value that is spatially distributed in at least two regions is provided. The scaffold has at least two regions with properties, such as porosity, strength, elastic modulus, osteoconductivity, and bioactivity that can be controlled and modified through fabrication processes that alter the pore size, pore size distribution, composition, and bonding of fiber and other additives. The value of the property can be provided with a gradient between each of the adjacent spatially distributed regions.07-12-2012
20100274362Cartilage particle tissue mixtures optionally combined with a cancellous construct - Mixtures, such as gels or pastes, comprising freeze-milled cartilage particles and exogenous growth factors are used for repairing chondral defects. Such mixtures may be applied to constructs comprising cancellous bone for implantation at the defect site. Suitable growth factors include variants of FGF-2, particularly variants that include a sole amino acid substitution for asparagine at amino acid 111 of the β8-β9 loop of the FGF-2 peptide. Such FGF-2 variants are released slowly and continuously at a constant rate from cartilage pastes. In other embodiments, the amino acid substituted for asparigine is glycine. Other variants that may be used include FGF-9 variants having truncated chains and a sole amino acid substitution in the β8-β9 loop of the FGF-9 peptide either for tryptophan at amino acid 144 or for asparagine at amino acid 143.10-28-2010
20120253473COMPOSITE MATRIX - The present invention relates to a composite matrix that includes a reinforcing textile portion having two surfaces coated over at least 90% of the respective surface areas thereof, by means of at least a first layer including at least one resorbable macro-molecule and having a collagen content of between 50 and 100 wt % relative to the total weight of the first layer; the invention also relates to a prosthesis including such a matrix and to a method for preparing said matrix.10-04-2012
20120253472TISSUE REPAIR DEVICES OF RAPID THERAPEUTIC ABSORBENCY - Novel implantable tissue repair medical devices are disclosed. The devices have a central fabric member having anti-adhesion films on both opposed sides. The films have pores, and are arranged such that the pores on the opposed films are offset. The devices are useful in hernia repair procedures.10-04-2012
20120226363METHOD FOR MANUFACTURING A DEVICE FOR REGENERATING BIOLOGICAL TISSUES - A device for regenerating biological tissues, particularly for regenerating tissues of the peripheral nervous system, the respective manufacturing method and the instrument used in the method, the regeneration device comprising a hollow tubular structure based on biocompatible material and having a structural porosity in which the pores are oriented substantially radially with respect to its longitudinal axis so as to minimize the formation of scar tissue around the damaged site and allow the growth of the biological tissue inside the pores and inside the duct defined by the hollow tubular structure and facilitate the transport of nutrients.09-06-2012
20100312358Implantable Repair Device - An implantable prosthesis for repairing or reinforcing a tissue or muscle wall defect including a first composite structure including at least one layer of a non-absorbable material, wherein the first composite structure has a central portion sized and shaped to cover at least a portion of the tissue or muscle wall defect, and has an outer periphery. The prosthesis further includes a second structure having a reinforced central region and an outer peripheral edge, a reinforcing element positioned between the first and second structures, and having an outer periphery and a stiffness greater than that of the first and second structures, and at least one pulling element coupled to the reinforced central region of the second structure. The second structure is coupled to the first structure substantially only at their respective peripheries.12-09-2010
20120239161AT LEAST PARTIALLY RESORBABLE RETICULATED ELASTOMERIC MATRIX ELEMENTS AND METHODS OF MAKING SAME - The present disclosure relates to reticulated elastomeric matrices, and more particularly to at least partially degradable elastomeric elements that are compressible and exhibit resilience in their recovery and that can be employed in diverse applications including, without limitation, biological implantation, especially in humans.09-20-2012
20110213470METHODS FOR USING A THREE-DIMENSIONAL STROMAL TISSUE TO PROMOTE ANGIOGENESIS - The present invention relates to a method for promoting blood vessel formation in tissues and organs. In particular, the method relates to implantation or attachment of an engineered three-dimensional stromal tissue to promote endothelialization and angiogenesis in the heart and related tissues. The three-dimensional stromal tissue of the present invention may be used in a variety of applications including, but not limited to, promoting repair of and regeneration of damaged cardiac muscle, promoting vascularization and healing during cardiac surgery, promoting blood vessel formation at anastomosis sites, and promoting vascularization and repair of damaged skeletal muscle, smooth muscle or connective tissue.09-01-2011
20110238186PREPARATION OF REGENERATIVE TISSUE SCAFFOLDS - Devices and methods for treating or repairing a tissue or organ defect or injury are provided. The devices can include tissue scaffolds produced from acellular tissue matrices and polymers, which have a stable three-dimensional shape and elicit a limited immunologic or inflammatory response.09-29-2011
20100168871ARTIFICIAL DURA BIOMEDICAL DEVICE AND BRAIN SURGERY METHOD UTILIZING THE SAME - An artificial dura biomedical device and a brain surgery method utilizing the same are disclosed. The steps includes: fixing an artificial dura to a partial skull; and fixing the partial skull with the artificial dura to a cut hole of a whole skull. The artificial dura biomedical device includes an artificial dura and a connecting element. The connecting element fixes the partial skull with the artificial dura.07-01-2010
20100168872BIOMATERIAL SCAFFOLDS FOR CONTROLLED TISSUE GROWTH - This invention relates to biomaterials for directional tissue growth which comprise soluble fibres having a variable cross-sectional area which dissolve in a directional manner in situ, thereby controlling the direction and rate of formation of microchannels within the biomaterial and allowing vectored and timed channelling through the biomaterial. This may be useful, for example in directing the growth of blood vessels, nerves and other repair cells through the biomaterial in defined directions.07-01-2010
20100168870SYSTEM FOR PROVIDING FLUID FLOW TO NERVE TISSUES - An apparatus and system for providing reduced pressure to a defect in a nerve is disclosed. The apparatus comprises a nerve conduit having a generally tubular shape that has walls including a luminal wall surrounding the tissue site to contain fluids within a luminal space between the tissue site to contain fluids within a luminal space between the tissue site and the luminal wall. The apparatus further comprises a manifold having a porous body and a connector for receiving reduced pressure, wherein the manifold is positioned within the luminal space adjacent the tissue site to distribute the reduced pressure to the defect. Additionally, a method for providing reduced pressure to a defect in a nerve is disclosed that includes implanting the nerve conduit and manifold at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.07-01-2010
20110270411NERVE GRAFT PREPARED BY ELECTROSTATIC SPINNING, THE PREPARING METHOD AND THE SPECIAL APPARATUS USED THEREFOR - The present invention discloses an artificial nerve graft prepared by electrostatic spinning, the preparing method and a special apparatus used therefor. Said artificial nerve graft is in the shape of a tube composed of nano-fiber that is prepared by electrostatic spinning of a polymer. The materials used in the present invention are bio-degradable materials and of desirable biocompatibility with human body. The product of the present invention is free of exogenous toxic substances or substances having side effects. Furthermore, the tube wall is of a 3-dimensional structure having micropores contained therein thereby providing a path for supplying nutritions required for the growth of nerve cells. Another advantage of the present invention is that necessary induction and space are provided for the growth of the nerve cells.11-03-2011
20120089237COMPOSITE AND ITS USE - The present invention relates to a composite comprising a structural part, a porous part, and at least two interconnecting parts arranged at a distance from each other and extending from the structural part to the porous part, thus connecting them to each other. The implant is characterised in that each interconnecting part is in the form of a band having a length, a width and a height, the width and the height both being independently at most 20% of the length of the band, and in that at least one of the interconnecting parts is at least partially embedded into the structural and porous parts.04-12-2012
20110320009MATRIX FOR TISSUE REPAIR - Implants include a porous layer made from a composition including a compound wherein collagen is cross-linked to a glycosaminoglycan, the porous layer being optionally joined to a collagen film.12-29-2011
20130024004METHOD AND SYSTEM FOR STERILIZING OR DISINFECTING BY THE APPLICATION OF BEAM TECHNOLOGY AND BIOLOGICAL MATERIALS TREATED THEREBY - A method of disinfecting a biological material provides disposing at least a portion of the biological material in the path of the gas cluster ion beam or in the path of the accelerated neutral beam so as to irradiate at least a portion of the biological material to disinfect the irradiated portion.01-24-2013
20130024005COMPOSITE IMPLANT - An implant includes a biocompatible framework material and a biologically-active material. The biologically-active material is embedded in the biocompatible framework material, and a portion of the biologically-active material is exposed to the outside of the implant.01-24-2013
20130173018METHOD FOR MANUFACTURING MULTILAYERED CELL SHEET, MULTILAYERED CELL SHEET HAVING VASCULAR NETWORK OBTAINED THEREBY, AND METHOD OF USE THEREOF - A method for manufacturing a multilayered cell sheet characterized in fabricating a vascular bed that constructs a vascular network extending to the surface from a channel for perfusing a medium, the channel being embedded in a gel; and layering a cell sheet onto the vascular bed to construct a vascular network in the cell sheet. This manufacturing method makes it possible to construct a vascular network in the cell sheet and to fabricate a thick multilayered cell sheet in a simple manner by layering cell sheets. Such a thick multilayered cell sheet is useful as an in-vivo tissue substitute in regenerative medicine involving a variety of tissues.07-04-2013
20080221704Three (3) distinct improvements (different fields of use) to the prior art or invention entitled instant face-lifter - There are three distinct improvements on the Instant Face-Lifter -the prior art-: Field of Use “A”, an intra-scalp round or oval-shaped device made of a biocompatible material, typically measuring 09-11-2008
20130144401APPARATUS INCLUDING MULTIPLE INVAGINATORS FOR RESTORING A GASTROESOPHAGEAL FLAP VALVE AND METHOD - A transoral gastroesophageal flap valve restoration assembly comprises a pair of tissue grippers. The device comprises an elongated member having a distal end arranged for being fed down an esophagus in communication with a stomach and a tissue shaper carried on the distal end of the longitudinal member. The tissue shaper comprises a first member adjacent the distal end of the elongated member and a second member. The first and second members are hingedly coupled to receive the stomach tissue to be shaped there between. The distal end of the elongated member has one of the tissue grippers that grips esophageal tissue oral of a Z line and the first member of the tissue shaper has the other tissue gripper that grips stomach tissue aboral of the Z line. A tissue fastener maintains the shaped stomach tissue.06-06-2013
20130123939COMPOSITIONS AND METHODS FOR REPAIR OR REGENERATION OF SOFT TISSUE - Disclosed are bioscaffolds and methods for use in soft tissue repair.05-16-2013
20130178949AIR IMPEDANCE ELECTROSPINNING FOR CONTROLLED POROSITY - Electrospun materials are fabricated using air-flow impedance technology, which results in the production of scaffolds in which some regions are dense with low porosity and others regions are less dense and more porous. The dense regions provide structural support for the scaffold while the porous regions permit entry of cells and other materials into the scaffold, e.g. when used for tissue engineering.07-11-2013
20130131830Textile-Templated Electrospun Anisotropic Scaffolds for Tissue Engineering and Regenerative Medicine - The present invention includes an anisotropic scaffold, which is prepared by electrospinning a solution of matrix material upon a textile template. The present invention further includes a method of preparing such scaffold. The anisotropic scaffold of the invention finds use in tissue engineering and regenerative medicine.05-23-2013
20130131829CELL INDUCTION MATERIAL - The object of the present invention is to provide a cell induction material, which can be easily formed, has excellent moldability because sintering is unnecessary, and decreases a strain on a human body caused by the exposure of the ends of a titanium wire. A metal mesh made by stockinette stitching with titanium wire is formed into a predetermined shape, and a cell induction material obtained by pressing the formed metal mesh is used. Further, the cell induction material with substantially no ends of the titanium wire that can be sensed through the sense in the vicinity of the surface is used.05-23-2013
20080200992IN VIVO HYDRAULIC FIXATION INCLUDING BIO-RIVETS USING BIOCOMPATIBLE EXPANDABLE FIBERS - The disclosure describes implantable medical products, that include dry or partially hydrated biocompatible constructs comprising collagen fibers configured to expand in situ after implantation to frictionally engage a bone tunnel wall to thereby affix the construct in the bone tunnel.08-21-2008
20100286795Stable Cartilage Defect Repair Plug - An apparatus and method of distributing a load to a cartilage defect repair plug is provided. A load is applied to a first articulation layer. The load is distributed to a second layer and the load is transferred in the normal direction to the first density of subchondral bone. The load is distributed to a third layer and the load is transferred in the normal direction to a second density of subchondral bone. The load is then distributed to a fourth layer and the load is transferred in the normal direction to a third density of subchondral bone.11-11-2010
20120283843SYNTHETIC SEROUS MEMBRANES AND METHODS FOR MAKING THE SAME - The present disclosure relates to casting-mold imprints and synthetic reproductions of serous membranes for tissue engineering and organogenesis. The imprints and synthetic membranes disclosed herein may be composed of distinct biocompatible polymers, which provide a mechanism for separation. Further disclosed herein are methods for making imprints and synthetic membranes that mimic natural scrous membranes.11-08-2012
20130158677IMPLANTABLE REPAIR DEVICE - An implantable prosthesis for repairing or reinforcing a tissue or muscle wall defect including a first composite structure including at least one layer of a non-absorbable material, wherein the first composite structure has a central portion sized and shaped to cover at least a portion of the tissue or muscle wall defect, and has an outer periphery. The prosthesis further includes a second structure having a reinforced central region and an outer peripheral edge, a reinforcing element positioned between the first and second structures, and having an outer periphery and a stiffness greater than that of the first and second structures, and at least one pulling element coupled to the reinforced central region of the second structure. The second structure is coupled to the first structure substantially only at their respective peripheries.06-20-2013
20130158676FLOWABLE TISSUE PRODUCTS - The present disclosure provides tissue fillers. The tissue fillers can include a plurality of tissue particles formed from acellular tissue matrix fragments. The tissue fillers can be used to fill tissue sites, such as voids formed after tissue resection.06-20-2013
20130123937METHOD OF PREPARATION OF BIOABSORBABLE POROUS REINFORCED TISSUE IMPLANTS AND IMPLANTS THEREOF - A biocompatible tissue implant. The tissue implant may be bioabsorbable, consists of a biocompatible polymeric foam. The tissue implant also includes a biocompatible reinforcement member. The polymeric foam and the reinforcement member are soluble in a lyophilizing solvent. The reinforcement may be annealed and/or coated.05-16-2013
20110313543POROUS MEMBRANES FOR USE WITH IMPLANTABLE DEVICES - A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular attachment, is impermeable to cells and cell processes, and allows the passage of analytes. The membrane allows for long-term analyte transport in vivo and is suitable for use as a biointerface for implantable analyte sensors, cell transplantation devices, drug delivery devices, and/or electrical signal delivering or measuring devices. The membrane architecture, including cavity size, depth, and interconnectivity, provide long-term robust functionality of the membrane in vivo.12-22-2011
20110313542ENGINEERED BIOLOGICAL NERVE GRAFT, FABRICATION AND APPLICATION THEREOF - An engineered three-dimensional structure includes living cells cohered with each other. The living cells suitably include Schwann cells and at least one other type of cell. The cells accompanying the Schwann cells can suitably be bone marrow stem cells or another type of cell having one or more anti-inflammatory properties. The structure is suitably a graft that facilitates restorative axon growth when the graft is implanted between the proximal and distal stubs of a severed nerve in a living organism. The graft can optionally include a plurality of acellular conduits extending between opposite axial ends of the graft. Bio-printing techniques can be used to assemble a three-dimensional construct that becomes through maturation an axon-guiding graft, by stacking a plurality of multicellular bodies, each of which includes a plurality of living cells cohered to one another to sufficiently to avoid collapsing when the multicellular bodies are stacked to form the structure.12-22-2011
20110313541METHODS FOR GENERATING CARTILAGE TISSUE - A hyaline-like, single layer cartilage tissue construct includes chondrogenic cells dispersed within an endogenously produced extracellular matrix. The single layer cartilage tissue construct has a glycosaminoglycan content substantially equal to the glycosaminoglycan content of native cartilage tissue. A method for generating a single layer cartilage tissue construct includes isolating a population of chondrogenic cells and then expanding the population of chondrogenic cells. Next, the population of chondrogenic cells is seeded into a bioreactor having a volume defined by oppositely disposed gas permeable membranes. The population of chondrogenic cells is then cultured in a serum-free culture medium for a time sufficient to permit the population of chondrogenic cells to differentiate and form the single layer cartilage tissue construct.12-22-2011
20120010726Adhesion-Resistant Surgical Access, Reinforcement and Closure Prosthetic - Described are devices and methods for reinforcing a layer of living tissue, which when affixed to a tissue layer prior to surgical incision, reinforces the tissue to be incised, provides a fibro-conductive matrix to promote healing in a preferred plane, and provides for a subsequent closure and fluidic seal. A partially or entirely absorbable growth matrix is disclosed, comprising two adhesion-resistant layers enclosing a cellular conductive medium for promoting fibrosis in a preferred plane. The cellular conductive portion is partially or entirely sequestered from surrounding tissue. The device is constructed in a physiologic range of tensile strengths and elasticity suitable for closure of the pericardium, peritoneum, or other typically thin membranes enclosing organs in the body, whose function is to prevent adhesions between tissue surfaces normally in motion.01-12-2012
20120029655IMPLANTABLE XENOGRAFT PREPARED FROM A NON-HUMAN TISSUE PORTION - An implantable xenograft intended for human recipients for correcting cardiovascular abnormalities. The xenografts are prepared from a non-human native tissue portion and are completely sterilized, acellular and exhibit a tensile strength generally higher than that of the native tissue. The uniqueness of the xenografts is that the outer surface of the tissue portion is impregnated with collagen nano-fibers. The implantable xenograft exhibits excellent storage stability, non-immunogenicity, non-thrombogenicity, non-cytotoxicity and non-calcifying properties.02-02-2012
20120029654ARTIFICIAL DURA MATER AND MANUFACTURING METHOD THEREOF - Disclosed are an artificial dura mater and manufacturing method thereof. The artificial dura mater includes electrospun layers prepared by electrostatic spinning, at least one of which is a hydrophobic electrospun layer. Further, above the hydrophobic electrospun layer, there can be at least one hydrophilic electrospun layer. A transition layer can be further included between the hydrophobic and the hydrophilic electrospun layers. Additionally, cytokines and/or medicines can be affixed to either or both of the hydrophobic and the hydrophilic electrospun layers, by way of bio-printing. The disclosed artificial dura mater shows good biocompatibility, enhances dural tissue regeneration, achieves excellent repairing effects, prevents adhesion, allows complete absorption, has good mechanical properties, ensures low infection rates, and can be loaded with therapeutic agents.02-02-2012
20120029653DEVICES AND METHODS FOR TREATING DEFECTS IN THE TISSUE OF A LIVING BEING - An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery.02-02-2012
20130197668STRUCTURE MODELED ON A BIOLOGICAL TISSUE AND METHOD FOR PRODUCING SAID STRUCTURE - The present invention relates to a method for producing a structure modeled on a biological tissue. The invention also relates to a structure which can be produced using the method according to the invention. According to an embodiment of the invention, a precursor of a biopolymer is locally irradiated with electromagnetic radiation in a targeted manner, wherein the irradiation, in particular the selection of the areas to be irradiated, is effected according to data which describe a structural construction at least components of the extracellular matrix of the biological tissue. In this case, the electromagnetic radiation is such that two-photon or multi-photon absorption takes place in the irradiated areas of the precursor and results in the precursor being polymerized to form the biopolymer in the irradiated areas, with the result being that the precursor is at least partially solidified there.08-01-2013
20130197663BIOMEDICAL PATCHES WITH ALIGNED FIBERS - A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.08-01-2013
20130197664Electrospun Porous Media - Espun material may function as a filtration medium or be put to other uses. The espun material may comprise espun poly(tetrafluoroethylene) (espun PTFE). One or more layers of the espun material may be included. The properties of the espun material can be tailored. For example, a gradient fabric may include espun PTFE. The gradient fabric may include two or more layers of espun PTFE.08-01-2013
20130197665PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME - Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.08-01-2013
20130197667Acellular Vascular Products - A product comprising a natural acellular xenogenic vascular tissue matrix having at least an 80% reduction in DNA content as compared to an untreated control vascular tissue matrix and being antigenically inert by being substantially free of epitopes capable of reacting with pre-formed human antibodies and also without having the ability to substantially activate complement. The invention also includes methods of preparing such products and uses of the products especially in bypass surgery.08-01-2013
20130197666METHODS AND DEVICES FOR PREPARING AND IMPLANTING TISSUE SCAFFOLDS - Methods and devices are provided for preparing and implanting tissue scaffolds. Various embodiments of scribing tools are provided that are configured to mark one or more predetermined shapes around a defect site in tissue. The shape or shapes marked in tissue can be used to cut a tissue scaffold having a shape that matches the shape or shapes marked in tissue. In one embodiment, the scribing tool used to mark a shape in tissue can also be used to cut the tissue scaffold.08-01-2013
20130197662COLLAGEN GEL FOR BONDING POROUS COLLAGEN-BASED MATERIALS WITH NON-POROUS COLLAGEN-BASED MATERIALS - The invention discloses a process for fabricating a biomaterial, comprising: a) joining a porous collagen based-material with a non-porous collagen based-material by applying a controlled amount of a bonding layer of a gel comprising collagen to a bonding surface of the non-porous collagen based-material, and contacting a surface of the porous collagen based-material with the gel applied to the bonding surface to partially hydrate a section of the porous material at the interface between the materials; b) drying the gel to dry to bond the materials together; and c) cross-linking the collagens in the bonding layer. Also disclosed are biomaterials and implants produced using the fabrication process.08-01-2013
20130204394THIN FILM TISSUE REPAIR MATRIX - A tissue repair matrix has an intricate pattern of loops, struts and bridges and is made of a super elastic alloy. The repair matrix includes hooks which improve the ingrowth when implanted and amorphic circles which provide rounded surfaces to the outer edges which made the repair matrix a-traumatic when implanted. When the repair matrix is cooled the molecular phase becomes martensitic which allows the tissue repair matrix to be compressed for easier insertion into a patient. When the tissue repair matrix is heated, the molecular phase changes to austenitic which causes the tissue repair matrix to expand to a size suitable for medical procedure.08-08-2013
20130204392METHOD FOR PROMOTING STEM CELL CHONDROGENESIS - There is provided a method for promoting stem cell chondrogenesis, comprising the step of culturing a population of stem cells on a plurality of imprints disposed on a substrate, the imprints being configured to selectively promote chondrogenesis of the stem cells.08-08-2013
20130204393MULTI-LAYER TISSUE SYSTEMS AND METHODS - Embodiments of the present invention encompass anti-adhesion wound dressings including patches made from amnion tissue obtained from human birth tissue. Exemplary amnion patches can be fabricated by folding a section of amnion over on itself with the epithelial layer on the outside of the folded patch and the fibroblast layer on the inside of the folded patch. Optionally, individual amnion tissue pieces can be sandwiched together to provide a multi-layer patch. Sufficient pressure is applied to the layered amnion to cause adherence between opposing faces of the fibroblast layers. The pressed fibroblast layers provide mechanical strength to hold the amnion patch together with the epithelial layers on the outsides of the amnion patch.08-08-2013
20130211542SYNTHESIS OF NANOTOPOGRAPHIC BIOMIMETIC MEMBRANES FOR TISSUE CULTURE, ENGINEERING AND PROSTHETICS APPLICATIONS - The present invention provide methods for preparing nanostructured membranes. The methods include: providing a substrate with a charged silanized surface; forming a multilayered membrane containing at least two polyelectrolytes; inducing polyelectrolyte phase separation; crosslinking the multilayered membrane; and covalently linking the multilayered membrane to the silanized surface. Methods for fabricating membrane replicas are also disclosed, as well as devices such as cell- and tissue-culture substrates that contain the membranes and membrane replicas. Resulting materials exhibit topographic features and compliance of the extracellular matrix in vivo.08-15-2013
20130211543TISSUE SCAFFOLD WITH CONTROLLED DRUG RELEASE - A three-dimensional hybrid scaffold capable of supporting cell activities such as growth and differentiation, and capable of controlled release of active pharmaceutical ingredients, characterized in that the scaffold comprises a first and a second biocompatible material, said first material shaped as a framework forming one or more open networks of voids, said second material comprising an ion exchange material, said ion exchange material being loaded with one or more active pharmaceutical ingredients.08-15-2013

Patent applications in class Tissue

Patent applications in all subclasses Tissue