Entries |
Document | Title | Date |
20090005881 | Composite Material Useful as Biomaterial and Its Preparation - The present invention aims at providing a biomaterial composite not having risks of pathogen infection and unfavorable side effects such as rejection response. According to the invention, there is provided a biomaterial composite, which comprises a polypeptide and a calcium phosphate compound, said peptide comprising the units of Formulas (I) to (III): | 01-01-2009 |
20090043399 | USE OF FUCANS FOR THE PURPOSE OF BONE GRAFTING, ENGINEERING AND REGENERATION - The present invention relates to the use of fucans with a weight-average molar mass of between 5000 and 100 000 g/mol, for the purposes of bone grafting, engineering and regeneration. | 02-12-2009 |
20090192628 | Bone Substitute Material, Medical Material Comprising the Bone Substitute Material and Method for Manufacturing the Bone Substitute Material - The object of the present invention is to provide a bone substitute material, medical material containing the bone substitute material and process for producing the bone substitute material wherein the bone material has excellent mechanical strength, biological affinity and biological activity. | 07-30-2009 |
20090216336 | BIORESORBABLE, MINERALISED MATERIAL FOR FILLING OSSEOUS DEFECTS - A bioresorbable and mineralized material for filling osseous defects includes a native and/or renatured collagen matrix of congregated collagen chains, in which essentially only a surface of the congregated collagen chains is mineralized. A shaped article for filling osseous defects includes such a material. A method for producing a shaped article for filling osseous defects from a liquid medium, includes the steps of deposition of a mineral substance, preferably from its dissolved ionogenic components, on a collagen matrix, precipitation of the mineralized collagen matrix, separation of the mineralized collagen matrix, transfer of the mineralized collagen matrix to a suspension, transfer of the suspension to a mold defining the shaped article, and freeze-drying of the suspension in the mold. | 08-27-2009 |
20090254194 | Phase-and sedimentation-stable, plastically deformable preparation with intrinsic pore forming, intended for example for filling bone defects or for use as bone substitute material, and method of producing it - The invention relates to a phase and sedimentation-stable, plastically deformable preparation with intrinsic pore formation that can be used for instance for filling bone defects and for augmentation, and also relates to a method for producing and using same. | 10-08-2009 |
20090319052 | BIOMATERIALS, THEIR PREPARATION AND USE - A calcium oxide-silica composite biomaterial either in amorphous state or crystalline state having an average pore size, as determined by the BET method, in the range of from 0.8 to 4 nm, wherein the calcium oxide-silica content of the biomaterial is at least 80 wt %, the balance being optionally one or more other materials and wherein the molar ratio of calcium oxide to silica is at least 0.1. | 12-24-2009 |
20100121459 | Tetra Calcium Phosphate Based Organophosphorus Compositions and Methods - Compositions and methods of their use to adhere a variety of materials together are disclosed herein. The compositions include at least tetra calcium phosphate, an effective amount of a compound that is structurally similar to phosphoserine, and can be mixed with an aqueous solution. The compositions provide adhesive and cohesive strength in both wet and dry environments and exhibit significant bond strength upon curing. | 05-13-2010 |
20100211183 | Chemical Mechanical Vapor Deposition Device for Production of Bone Substitute Material - A method for fabricating a substitute component for bone, including the processes of: provision of a chemical spray including at least three of calcium chloride, hydrogen phosphate, hydrogen carbonate and water to form a combined solution; reaction and precipitation of the combined solution onto a substrate; allowing the precipitated particles to form a porous structure on the substrate; applying substantially isostatic pressure to the porous structure to form a compressed structure; and (optional) providing one or more through-holes in the compressed structure to promote osteoinduction. | 08-19-2010 |
20100305714 | SYNTHETIC BONE SUBSTITUTE, METHOD FOR PREPARING SAME AND METHOD FOR FILING A CAVITY IN A SUBSTRATE - A synthetic bone substitute has a porous foam structure comprising a bio-resorbable polymer and a bio-ceramic filler material. A plasticizer is used for softening the porous foam structure such that the synthetic bone substitute may be compressed by an external force. Due to its elasticity, the synthetic bone substitute may restore its original form after releasing the external force. Furthermore, due to dissipation of the plasticizer, the porous foam structure can attain substantial rigidity thereby functioning as lightweight, stable bone substitute. Such a compressible bone substitute can be compressed, then inserted through a small opening hole to a cavity and once in a cavity restore its original volume and rigidity. | 12-02-2010 |
20100312355 | BONE GRAFT MATERIAL AND USES THEREOF - Bone graft compositions for repairing bone defects, which are characterized by a chemical composition of cementitious, non-cementitious, highly-resorbable and poorly-resorbable particulate substances, and further characterized by a specific particle size distribution that includes two or more different ranges of particle size, are disclosed. Further disclosed are articles of manufacturing and unit dosage forms containing the bone graft compositions, methods of repairing bone defects utilizing the bone graft compositions, and processes of preparing the same. Also provided are applicators for applying flowable mixtures formed by mixing a dry composition and a liquid carrier, which are particularly useful for preparing and applying bone graft compositions, as well as methods of using same. | 12-09-2010 |
20100324695 | ARTIFICIAL BONE AND JOINT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE - The present invention provides a ceramic porous body for in-vitro and in-vivo use comprising a composition comprising a calcium aluminate (CA) containing phase and optionally at least one of an accelerator, a retarder, a surfactant, a foaming agent, a reactive alumina, water, a fiber, and a biologically active material, and combinations thereof. Ceramic compositions are provides as well as method of using the ceramic compositions and methods of manufacturing a ceramic porous body. The ceramic porous bodies of this invention may be used as artificial bones, joints, in-vitro support structures, and in-vivo support structures for cells, tissues, organs, and nerve growth and regeneration. | 12-23-2010 |
20100331998 | Electrokinetic device for tissue repair - Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant. | 12-30-2010 |
20110015757 | Plasticized Bone and Soft Tissue Grafts and Methods of Making and Using Same - The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room. | 01-20-2011 |
20110040389 | HYDROXYAPATITE, BIOCOMPATIBLE GLASS AND SILICON-BASED BONE SUBSTITUTE, PRODUCTION PROCESS AND APPLICATIONS THEREOF - The disclosed invention is based on hydroxyapatite, biocompatible glass and silicon, aiming to develop an improved bone substitute, which presents higher mechanical resistance, bioactivity and osteoregeneration, and susceptible of being used in several medical and surgical fields, with application in the treatment of bone disease caused by trauma or genetic factors, as osteoconductive support for cellular growth. The abovementioned bone substitute comprises hydroxyapatite, a biocompatible glass of the P | 02-17-2011 |
20110106272 | Devices and Methods for Tissue Engineering - A resorbable tissue scaffold fabricated from bioactive glass fiber forms a rigid three-dimensional porous matrix having a bioactive composition. Porosity in the form of interconnected pore space is provided by the space between the bioactive glass fiber in the porous matrix. Strength of the bioresorbable matrix is provided by bioactive glass that fuses and bonds the bioactive glass fiber into the rigid three-dimensional matrix. The resorbable tissue scaffold supports tissue in-growth to provide osteoconductivity as a resorbable tissue scaffold, used for the repair of damaged and/or diseased bone tissue. | 05-05-2011 |
20110118850 | Bioactive Grafts and Composites - Disclosed are various bioactive grafts and/or biocompatible materials and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized. In another embodiment, an orthopaedic implant includes an antibacterial polysaccharide. The implant may also include an osteostimulative agent. | 05-19-2011 |
20110144763 | DYNAMIC BIOACTIVE BONE GRAFT MATERIAL HAVING AN ENGINEERED POROSITY - The present disclosure relates to a dynamic bioactive bone graft material having an engineered porosity. In one embodiment, a bone graft material is provided having bioactive glass fibers arranged in a porous matrix that is moldable into a desired shape for implantation. The material can be substantially without additives and can include at least one nanofiber. The porous matrix may include a combination of one or more pore sizes including nanopores, macropores, mesopores, and micropores. In another embodiment, a bone graft implant is provided having a matrix comprising a plurality of overlapping and interlocking bioactive glass fibers, and having a distributed porosity based on a range of pores provided in the bioactive glass fibers. The distributed porosity can comprise a combination of macropores, mesopores, and micropores, and the matrix can be formable into a desired shape for implantation into a patient. | 06-16-2011 |
20110144764 | BONE GRAFT MATERIAL - The present disclosure relates to a bone graft material and a bone graft implant formed from the material. In some embodiments, the bone graft implant comprises a porous matrix having a plurality of overlapping and interlocking bioactive glass fibers and a plurality of pores dispersed throughout the matrix, whereby the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the pores are characterized by pore diameters ranging from about 100 nanometers to about 1 millimeter. The implant may be formed into a desired shape for a clinical application. The embodiments may be employed to treat a bone defect. For example, the bone graft material may be wetted and molded into a suitable form for implantation. The implant may then be introduced into a prepared anatomical site. | 06-16-2011 |
20110144765 | Process For Producing Porous Scaffolds From Sinterable Glass - The invention relates to a process for producing a porous glass construct with interconnected porosity, the resulting porous construct and its use as a macroporous scaffold in bone repair and regeneration. | 06-16-2011 |
20110153029 | BIORESORBABLE AND FLEXIBLE MEMBRANES EXHIBITING ASYMMETRIC OSTEOCONDUCTIVE BEHAVIOR IN BOTH FACES - The present invention concerns a process for the preparation of a flexible composite membrane, biocompatible and biodegradable, obtained from natural or synthetic materials, containing inorganic osteoconductive elements with a gradient of concentration along the thickness of the membrane or an asymmetric concentration of such elements in both sides of the membrane. The membrane may be obtained by gravitational deposition of the osteoconductive elements during solvent evaporation. The membrane is aimed to be used in vivo, in guided tissue regeneration, as a sealant for defects or structures for tissue engineering, or as coatings for biomaterials. The membrane exhibits one side featuring osteoconductive properties, that interacts favorably with mineralized tissues or other implanted bioactive materials, and the other side prevents the penetration or invasion of other tissues. | 06-23-2011 |
20110160870 | EXPANDABLE IMPLANT - An implant system includes a fixation device that, in turn can include an expandable implant alone or in combination with an auxiliary implant. The expandable implant includes an expandable implant body that is made from an expandable material. The expandable material includes a polymer matrix and an expandable gas source contained within at least a portion of the polymer matrix. The implant system can further include an energy source configured to heat the polymer matrix to a temperature above its glass transition temperature, thereby causing the gas source to expand inside the polymer matrix. The fixation device can further include an insertion instrument configured to implant the fixation device into an anatomical cavity. | 06-30-2011 |
20110190904 | INTEGRATED MULTI-MATERIAL IMPLANTS AND METHODS OF MANUFACTURE - Provided are methods and systems for fabricating multimaterial bodies in a layer-wise fashion, which bodies may be used bone-stabilizing implants. The multimaterial bodies include rigid and flexible portions that are integrally formed with one another. The multimaterial bodies may be softened or stiffened in specific areas to match the biological or anatomical features of a bone. | 08-04-2011 |
20110270407 | MEDICAL OR VETERINARY MATERIAL, METHOD FOR THE PRODUCTION AND USE THEREOF - A sterile endosseous implant suitable for an insertion into a living tissue, the implant includes a moulded piecework made of poly (etheretherketon) as a binder and the moulded piecework includes an external graft surface embedded crystallized calcium phosphate particles emerging from the surface. | 11-03-2011 |
20110282465 | IN SITU FORMING BIPHASIC OSTEOCHONDRAL PLUG - An osteochondral plug includes a first scaffold and a second scaffold. The first scaffold may be a solid scaffold containing one or more pendant reactive functional groups. The second scaffold capable of reacting with the one or more pendant reactive functional groups of the first scaffold | 11-17-2011 |
20110288651 | Supercritical Carbon-Dioxide Processed Biodegradable Polymer Nanocomposites - A biodegradable nanocomposite and a method of forming a biodegradable nanocomposite are provided. In one aspect, the biodegradable nanocomposite includes a biodegradable polymer and a reinforcing agent substantially dispersed throughout the biodegradable polymer by rapid depressurization of a supercritical fluid. The biodegradable nanocomposite further includes a plurality of pores formed in the nanocomposite, the plurality of pores having an average pore size greater than about 100 μm. | 11-24-2011 |
20110288652 | MATERIALS AND METHODS FOR TREATING CRITICALLY SIZED DEFECTS IN MOUSE BONE - Scaffolds equipped to include biologically active reagents such as proteins sized and engineered specifically for use in a mouse were made and implanted into mice. The scaffold was specifically designed for use in a mouse femoral critical sized defect Scaffolds. Special care was taken when casting these scaffolds to ensure that the material used to form the body of the scaffold did not include defects such as a large number of macroscopic holes that could compromise the structural integrity of these very small devices. Some of these scaffolds include a hollow center that accommodate a rod that ran the longitudinal length of the scaffold extending into the adjacent bone to anchor the scaffold to the bone. Scaffold also include at least one channel that extended from the outside of the structure towards its center and could be hold a liquid or paste comprising for example exogenous BMP-2. | 11-24-2011 |
20110288653 | Filler Means, Feeding Device and Method for the Forming of a Support Structure in a Bone Cavity - The invention relates to dry free-flowing filler ( | 11-24-2011 |
20110295383 | BONE SUBSTITUTE MATERIAL FOR MEDICAL USE AND METHOD OF PRODUCING THE SAME - There is disclosed a bone substitute material for medical use which satisfies all the requirements of (1) no histotoxicity, (2) osteoconductivity, (3) bone replacement capability, and (4) mechanical strength necessary for a bone reconstruction operation. The bone substitute material for medical use is predominantly composed of carbonate apatite and produced through the formation of carbonate apatite by contacting a block of calcium compound with a phosphate-containing solution, wherein the calcium compound block contains substantially no powders, and at least one of said calcium compound block and said phosphate solution contains a carbonate group, without any sintering. The block of calcium compound is preferably one prepared using an artificially synthesized calcium compound, most preferably a foamed calcium compound. | 12-01-2011 |
20110307073 | Resorbable Scaffolds For Bone Repair And Long Bone Tissue Engineering - Bioresorbable scaffolds for bone engineering, such as repair of bone defects, particularly long bone defects, or augmentation of bone length are described. Scaffolds are porous and comprise multiple side channels. In one embodiment, scaffolds are made from layers of micro-filament meshes comprising polycaprolactone (PCL) or a PCL-composite sequentially laid in incremental 60 degrees of rotation to produce a 0/60/120 degree layering pattern, providing for the formation of interconnected pores. The scaffold can comprise a central channel filled, packed or infused with suitable agents such as bioactive agents. Furthermore, the scaffolds are stiff but yet fracture resistant and with sufficient bending, compressive and torsional strength suitable for bone engineering. The slow degradation of the scaffold is sufficient for the 3D matrix to maintain structure integrity and mechanical properties during the remodelling process. | 12-15-2011 |
20110307074 | BIOMATERIALS FOR USE IN METHODS OF BONE REPLACEMENT THERAPY - This invention relates to biomaterials, said biomaterials for use in methods to control and/or induce bone growth. Particularly, the invention relates to macroporous calcium phosphate biomaterials pre-loaded with certain amounts of osteoclastic activity inhibitors for use in methods to control and/or induce bone growth in primates. | 12-15-2011 |
20110313538 | BI-LAYERED BONE-LIKE SCAFFOLDS - Disclosed are biomedical scaffolds that may be used, for example, for treatment of bone diseases and bone repair. Methods of preparing such scaffolds are also disclosed. These scaffolds permit nutrient and ion flow such that bone regeneration in the area surrounding the scaffold is promoted. Also disclosed are kits that include the scaffolds set forth herein. | 12-22-2011 |
20110313539 | MEDICAL SUPPLIES AND METHOD OF PRODUCING THE SAME - Metallic medical supplies include a metallic material as a base material, and a film having micro pores and/or micro unevenness on a surface of the base material, wherein the micro pores and/or micro unevennesses are impregnated with iodine or iodine compounds. | 12-22-2011 |
20120035742 | Methods, Devices and Systems for Bone Tissue Engineering Using a Bioreactor - An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusion. In an embodiment, the bioreactor has a mold into which perfusion medium is pumped under pressure and multiple ports through which the medium exits the mold. | 02-09-2012 |
20120046758 | DEVICES AND METHODS FOR TREATING DEFECTS IN THE TISSUE OF A LIVING BEING - An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. | 02-23-2012 |
20120130506 | BONE SUBSTITUTE MATERIAL - The invention relates to: a biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material comprising a sintered CAP core and at least one uniform and closed epitactically grown layer of nanocrystalline HAP deposited on top of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, i.e. a length of 30 to 46 nm and a width of 14 to 22 nm, a process of preparing the above CAP/HAP bone substitute material comprising the steps of a) preparing a sintered CAP core material, b) immersing the sintered CAP core material in an aqueous solution at a temperature between 10° C. and 50° C. to start the transformation process of CAP to HAP whereby a uniform and closed epitactic grown layer of nanocrystalline hydroxyapatite will be formed on the CAP core material surface, the epitactically grown nanocrystals having the same size and morphology as human bone mineral, c) stopping the transformation by separating solid material from the aqueous solution at a time when a uniform and closed coating of at least one nanocrystalline layer of HAP is present but before the transformation process is finished completely, and d) optionally sterilizing the separated material coming from step c), and the use of the above bone substitute material as implant or prosthesis for bone formation, bone regeneration, bone repair and/or bone replacement at a defect site in a human or animal. | 05-24-2012 |
20120143347 | Elastomeric, Polymeric Bone Engineering and Regeneration Compositions and Methods of Making - The invention relates to elastomeric, polymeric bone substitute compositions, methods for their preparation and their use in clinical applications, such as bone engineering and regeneration applications. The bone substitute compositions are osteoconductive in the absence of a biomolecule component. The bone substitute compositions are capable to regenerate bone in vitro or in vivo. The bone substitute compositions can be implanted into a bone defective site of a patient, and particularly, in the orthopedic, dental and caraniofacial areas of the patient. | 06-07-2012 |
20120172998 | BONE PROSTHETIC MATERIAL - Disclosed is a bone prosthetic material that is capable of preventing a plurality of members from being disconnected due to a difference in the coefficient of thermal expansion, and that is also capable of facilitating the work to insert them while ensuring the bone replacement capability. Provided is a bone prosthetic material comprising: a plurality of prosthetic material pieces and which include bioabsorbable materials having different absorption rates, and which are adjacent and connected to each other; and a joint which is provided in a connecting surface between these prosthetic material pieces and, and which is mutually combined to connect the prosthetic material pieces and while limiting displacement in directions along the connecting surface. | 07-05-2012 |
20120203356 | CALCIUM SULFATE COMPOSITE PARTICLES INCLUDING AGGREGATED CALCIUM SULFATE NANOPARTICLES AND METHOD OF USE FOR BONE AUGMENTATION - Calcium sulfate composite particles for bone augmentation are disclosed. The composite particles are composed of aggregated calcium sulfate nanoparticles of a diameter from about 50 to about 800 nm, which include a mixture of calcium sulfate dihydrate and calcium sulfate hemihydrate. The composite particles have a diameter from about 200 to about 1,200 μm, and a mean half-life no less than 18 days. Further disclosed is a bone grafting material for bone augmentation. The bone grafting material includes a mixture of the calcium sulfate composite particles and a second type of calcium sulfate particles having a particle diameter from about 2 to about 60 μm, at a ratio from 1:1 to 4:1. The method of using the composite particles and the bone grafting material for bone augmentation is also disclosed. | 08-09-2012 |
20120259426 | PLGA/HYDROXYAPATITE COMPOSITE BIOMATERIAL AND METHOD OF MAKING THE SAME - The present invention is a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and nano-sized hydroxyapatite particles exposed on its surface using a gas foaming particle leaching (GF/PL) method. A further embodiment of this invention involves coating this PLGA/hydroxyapatite biomaterial with an adherent, fast, uniform coating of a mineral such as apatite. The PLGA polymer portion of the composite provides sufficient mechanical strength to replace bone and is degradable over time to allow new bone tissue ingrowth. The incorporated hydroxyapatite particles increase the composite material's osteogenic properties by providing sites for tissue attachment and propagation. Finally, a uniform coating of mineral apatite on the surface of this novel biomaterial composite further enhances its osteogenic qualities. | 10-11-2012 |
20120277882 | IMPLANT COMPOSITE PARTICLE, METHOD FOR MAKING THE SAME, AND USES THEREOF - A biocompatible implant composite particle and the method of making the same are provided. The implant composite particle includes a bone filler particle and a plurality of fibers, in which each fiber is partially embedded in the bone filler particle, and has a free portion extending from a surface of the bone filler particle. Both bone filler particle and fibers are biocompatible. The biocompatible implant composite can be used in a bone filler material for bone defects. | 11-01-2012 |
20120330435 | Implants and Methods for Correcting Tissue Defects - The present invention relates to mosaic implant ( | 12-27-2012 |
20130006380 | DEVICE FOR COVERING AND/OR RECONSTRUCTING A BONE DEFECT SITE, AND METHOD FOR PRODUCTION THEREOF - A device for covering and/or reconstructing a bone defect site and a method for producing a cap of a covering device for a bone defect site, wherein the device for covering and/or reconstructing a bone defect site consists of a cap (moulded shell, rigid shell, shaped body) and of at least one fixing means for fixing the cap on a bone. The cap is distinguished by having a dimensionally stable (rigid) nature, and a wall of the cap directed towards the bone defect or a wall of the cap directed away from the bone defect corresponds to the shape of the regenerated bone. | 01-03-2013 |
20130090742 | APPARATUS AND METHOD FOR BONE AUGMENTATION - A scaffold for bone augmentation constituted of: a superstructure configured and dimensioned to substantially ameliorate a bone defect, the superstructure comprising: a biocompatible material having a strength and tensility sufficient to be permanently stationed between an upper jaw and a lower jaw; a first face arranged to face the bone defect; a second face, opposing the first face; a plurality of perforations extending from the first face to the second face; and bone augmentation material deposited within said plurality of perforations, wherein the perforations are of a size sufficient to secure bone augmentation material deposited within the plurality of perforations. | 04-11-2013 |
20130123935 | METHOD OF LENGTH PRESERVATION DURING BONE REPAIR - An implant, including a web structure having a space truss with two or more planar truss units having a plurality of struts joined at nodes is used to join two separated bone portions. The web structure is configured to be disposed in the space between the separated bone portions to enhance fusion. In some embodiments, the implant comprises a non-planar surface. | 05-16-2013 |
20130131825 | BONE GRAFT - The present invention relates to a novel bone graft and methods for producing said graft. Said bone graft can be used for surgical, plastic and/or cosmetic bone replacement for a patient in need thereof. The bone graft is made of a scaffold or matrix of sheet material having a 3-dimensional pattern of a continuous network of voids and/or indentations for enhancing new bone growth. | 05-23-2013 |
20130138222 | Osteoconductive Implants and Methods of Using Same - Implants for promoting bone growth and methods of using same, the implants including a perforated placental membrane sheet wrapped around an osteoconductive material composed of bone chips, bone granules, bone powders or combinations thereof, the osteoconductive material being configured for providing a scaffold upon which bone growth can occur. The placental membrane sheet acts to maintain the osteoconductive material in a cohesive, organized configuration within a site of a patient where bone growth is to be induced. The perforations in the placental membrane sheet create passageways in the exterior of the implant through which the osteoconductive material can communicate with adjacent bone surfaces which are to be fused. | 05-30-2013 |
20130138223 | BIOIMPLANT - Provided is a bioimplant superior in antimicrobial action and safety in the body. The bioimplant according to the present invention comprises a base material of metal, ceramic, or plastic and a thermal spraying film of a calcium phosphate-based material formed at least partially thereon and the silver concentration in the thermal spraying film is 0.02 wt % to 3.00 wt %. | 05-30-2013 |
20130173013 | Composite Bone Graft, Method of Making and Using the Same - The invention is directed to a composite bone graft for implantation in a patient, and methods of making and using the composite bone graft, along with methods for treating patients by implanting the composite bone graft at a site in a patient. | 07-04-2013 |
20130184835 | BIODEGRADABLE SCAFFOLDS - In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects. Further embodiments of the present invention pertain to methods of making the compositions of the present invention. | 07-18-2013 |
20130268087 | BONE GRAFT - The present invention relates to a novel bone graft and methods for producing said graft. Said bone graft can be used for surgical, plastic and/or cosmetic bone replacement for a patient in need thereof. The bone graft is made of a scaffold or matrix of sheet material having a 3-dimensional pattern of a continuous network of voids and/or indentations for enhancing new bone growth. | 10-10-2013 |
20130274891 | BIOMATERIAL AND METHOD FOR ITS REALISATION - Porous biocompatible composite biomaterial, useable as a drug delivery system or as spacer or as bone substitute, such as for example for filling bone lacunae or for substituting damaged parts of bone tissue, or for fixing prosthesis of various types, or for thickening bones weakened by illness such as osteoporosis or the like, including a component adapted to form a porous structural matrix and a soluble component, wherein the soluble component is in form of powder and granules or other similar agglomerates so as to have mechanical support characteristics and osteoinductive and osteoconductive characteristics in the entire volume occupied by the biomaterial, and a method for obtaining the biomaterial. | 10-17-2013 |
20130282138 | INTERSPINOUS BONE IMPLANT DEVICE - A bone implant system is provided including a bone graft body having at least a demineralized surface for implantation at a bone site, the bone graft body including at least one attachment member. At least one bone delivery carrier including a covering is provided, the carrier configured to be attachable to the bone graft body and including at least one compartment. An affixing member may be provided for attaching the at least one bone delivery carrier to the at least one attachment member of the bone graft body. A demineralized bone matrix material is disposed within the at least one compartment, wherein the covering retains the demineralized bone matrix material for placement at the bone site and facilitates transfer of cells into and out of the covering. | 10-24-2013 |
20130282139 | Vertical Bone Augmentation Using Endothelial Progenitor Cells - A method of facilitating augmentation of osseous tissue on a surface of a bone is disclosed. The method includes combining a scaffolding, an enclosure substantially enclosing the scaffolding relatively to the surface of the bone and a cell culture seeded onto the scaffolding. | 10-24-2013 |
20140031950 | BONE GRAFT MATERIALS AND METHODS - Compositions, materials, methods and kits for bone grafting are described. In some embodiments, a bone graft composition includes about 15% to about 20% by weight collagen, about 55% to about 70% by weight bioactive glass, and about 15% to about 30% by weight a calcium phosphate. The bioactive glass and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition. In some embodiments, a bone graft composition includes a collagen matrix and a plurality of bioactive glass particulates dispersed throughout the collagen matrix. The collagen matrix is about 20% to about 60% by weight of the bone graft composition, and the bioactive glass is about 40% to about 80% of the bone graft composition. In some embodiments, a majority of the bioactive glass particulates are about 53 μm to about 425 μm in size. | 01-30-2014 |
20140039640 | METHOD OF DOSE CONTROLLED APPLICATION OF BONE GRAFT MATERIALS BY WEIGHT - Methods of providing dose controlled application of bone graft materials are disclosed. In particular, methods for determining a target quantity of bone graft material for clinical application in order to ensure maximum clinical results are provided. These methods comprise determining the target weight of the material to be applied. | 02-06-2014 |
20140058527 | CARTILAGE REPAIR MIXTURE CONTAINING ALLOGRAFT CHONDROCYTES - The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or mixed polymers with allograft chondrocytes added in an amount ranging from 2.5×10 | 02-27-2014 |
20140142717 | POROUS COMPOSITE WITH GRADED BIOABSORBABILITY, ARTIFICIAL BONE USING THE SAME, AND MANUFACTURING METHOD THEREOF - The object of the present invention is to provide a calcium phosphate-collagen fiber composite which has an excellent mechanical property, can induce bone replacement by rapid bone remodeling, and can be used in a high-load region. The object can be solved by a porous composite comprising a calcium phosphate crystal and a collagen fiber at a weight ratio of 80:20 to 20:80, wherein (1) a bioabsorbability of the porous composite is graded, and (2) the density of the porous composite determined by gravimetric method is 300 to 1500 mg/cm | 05-22-2014 |
20140195004 | Implants and Methods for Correcting Tissue Defects - The present invention relates to mosaic implant ( | 07-10-2014 |
20140236312 | CORTICAL BONE SCAFFOLD FOR GUIDED OSTEON REGENERATION IN LOAD-BEARING ORTHOPAEDIC APPLICATIONS - Described is an artificial bone scaffold with an architecture resembling cortical bone, including microchannel-like structures resembling osteons. The scaffold enhances the ability of osteoblasts to secrete organized collagen and mineralize extracellular matrix within the osteon-like channels, thus promoting scaffold strength. | 08-21-2014 |
20140257514 | BONE GRAFT SUBSTITUTE - A bone graft substitute in the form of an implantable three-dimensional scaffold that includes calcium phosphate and has pores. The scaffold is impregnated with a calcium and/or phosphate containing substance, and the dissolution rate DR | 09-11-2014 |
20140371869 | PRODUCTION OF TISSUE ENGINEERED DIGITS AND LIMBS - The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion. | 12-18-2014 |
20150018965 | BIOIMPLANT - Provided is a bioimplant which is capable to inhibit the biofilm formation over a long period of time after an operation. The bioimplant of the present invention comprises a base material of metal, ceramic, or plastic and a thermal spraying film of a calcium phosphate-based material formed at least partially thereon and the silver concentration in the thermal-spray film is 0.05 wt % to 3.00 wt %. | 01-15-2015 |
20150045906 | METHOD FOR FUSION OF FRACTURED OR VOIDED STERNUM POST STERNOTOMY - Disclosed herein are improved surgical techniques for repairing bone defects in a sternum during a sternotomy procedure and implants adapted for such techniques. In an exemplary embodiment, provided is a fusion strip made of an osteoconductive material and of a dimension that is especially adapted for improved repair of sternal bone defects. | 02-12-2015 |
20150081034 | COMBINED SPACE MAINTENANCE AND BONE REGENERATION SYSTEM FOR THE RECONSTRUCTION OF LARGE OSSEOUS DEFECTS - Systems, methods and compositions useful for treatment of traumatic bone injuries are provided. In one embodiment, a bone reconstruction system comprising a space maintaining composition comprising porous polymethylmethacrylate; and an osseous generating construct comprising a polymethylmethacrylate chamber that comprises one or more osseous generating materials is provided. Associated compositions and methods are also provided. | 03-19-2015 |
20150148911 | METHOD FOR MANUFACTURING BONE IMPLANTS AND BONE IMPLANT - To manufacture the implant a nanopowder of synthetic hydroxyapatite (Hap) is used having a hexagonal structure, average grain size in a range from 3 to 30 nm and the specific surface area greater than 200 m | 05-28-2015 |
20150297349 | BONE SUBSTITUTE AND METHOD FOR PRODUCING THE SAME - The invention relates to a bone substitute ( | 10-22-2015 |
20150353509 | A Compound 1,4,5-Trisubstituted1,2,3-Triazole, Process To Obtain And Uses Thereof - The present invention relates to compounds, containing a central 1,4,5-trisubstituted 1,2,3-triazole core and a reactive appendage appropriate to form covalent “click” bonds on the surface of materials functionalized with reactive groups including: azide, terminal alkyne, cyclooctalkyne, thiol, maleimide or thiolacid groups. These compound are nonpeptide mimetics of RGD (Arg-Gly-Asp) and/or, OGP | 12-10-2015 |
20160081803 | BONE GRAFT MATERIALS AND METHODS OF USE - Osteoinductive and osteoconductive compositions for bone graft which utilize less allograft tissue, and methods for their production, are provided. The compositions and methods contain a combination of fibers of demineralized bone matrix from allograft bone and fibers of non-allograft bone material. The fibers of non-allograft bone material comprise non-fibrous demineralized bone matrix particles embedded within or disposed on the fibers of non-allograft bone material. The non-allograft fibers of the composition contain a bone void filler of collagen and one or more ceramics embedded with demineralized bone matrix particles. In some embodiments, the composition also contains a bioactive agent. | 03-24-2016 |
20160128833 | BONE GRAFT MATERIALS AND METHODS - Compositions, materials, methods and kits for bone grafting are described. In some embodiments, a bone graft composition includes about 15% to about 20% by weight collagen, about 55% to about 70% by weight bioactive glass, and about 15% to about 30% by weight a calcium phosphate. The bioactive glass and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition. In some embodiments, a bone graft composition includes a collagen matrix and a plurality of bioactive glass particulates dispersed throughout the collagen matrix. The collagen matrix is about 20% to about 60% by weight of the bone graft composition, and the bioactive glass is about 40% to about 80% of the bone graft composition. In some embodiments, a majority of the bioactive glass particulates are about 53 μm to about 425 μm in size. | 05-12-2016 |
20160135955 | SHAPE-MEMORY-ACTUATED MATERIALS FOR ACCELERATED HEALING OF ORTHOPEDIC INJURIES - A three component system for repairing critically sized bone defects having a first shape memory polymer (SMP) component formed as a scaffold that fills the defects, a second SMP component formed as a restricting sleeve that stabilizes and supports osseointegration and osteoconduction, and a third SMP component formed as a two-dimensional cell culture substate for engineering periosteal grafts. | 05-19-2016 |
20160144032 | COMPOSITION FOR NEW BONE FORMATION, AND NEW BONE FORMATION SYSTEM - Provided are a composition for new bone formation and a new bone formation system, which when used to fill a bone treatment site does not effuse from the filled site due to flow of bone marrow fluid or the like, and which can promote formation of new bone at the bone treatment site. By employing a composition for new bone formation containing microparticles of a material that can emit heat in response to an external signal, and a carrier for the microparticles, formation of new bone at the bone treatment site can be promoted. | 05-26-2016 |