| Entries |
| Document | Title | Date |
|---|
| 20080208326 | C3 exoenzyme-coated stents and uses thereof for treating and preventing restenosis - This invention provides a stent for implantation in a blood vessel or other tissue, wherein the stent is coated with or contains C3 exoenzyme, a chimeric version thereof or an inhibitor of RhoA. This invention also provides a method for treating or inhibiting the onset of restenosis in a subject which comprises implanting one of the instant stents in the subject's blood vessel. | 08-28-2008 |
| 20130085565 | ELECTROSPUN PTFE COATED STENT AND METHOD OF USE - A stent or other prosthesis may be formed by coating a single continuous wire scaffold with a polymer coating. The polymer coating may consist of layers of electrospun polytetrafluoroethylene (PTFE). Electrospun PTFE of certain porosities may permit endothelial cell growth within the prosthesis. | 04-04-2013 |
| 20090287301 | Coating for medical implants - A medical implant can include a body including a bioerodible metal and a coating overlying a surface of the bioerodible metal. The coating can include a matrix that includes a fatty acid salt and nano-particles within the matrix. | 11-19-2009 |
| 20090192595 | MEDICAL IMPLANT - Disclosed herein is a medical implant including an implant body of which at least a part is comprised of a biodegradable metal, wherein the part comprised of the biodegradable metal has a crystal grain diameter of not more than 10 μm. | 07-30-2009 |
| 20090192594 | IMPLANT HAVING A BASE BODY OF A BIOCORRODIBLE ALLOY AND A CORROSION-INHIBITING COATING - An implant having a base body consisting entirely or in part of a biocorrodible metallic material wherein at least the parts of the base body made of the biocorrodible metallic material are covered with a corrosion-inhibiting coating. The coating comprises a primer layer of a first biodegradable polymer material comprising a poly(D,L-lactide) (PDLLA) with a degree of polymerization in the range of 5 to 20 and a protective layer of a second biodegradable polymer material comprising a diblock copolymer (PEG/PLGA) of polyethylene glycol (PEG) and poly(D,L-lactide-co-glycolide) (PLGA) applied to the primer layer. | 07-30-2009 |
| 20110202126 | Polymer-Bioceramic Composite Implantable Medical Device with Different Types of Bioceramic Particles - Implantable medical devices fabricated from polymer/bioceramic composites with different types of bioceramic particles are disclosed. | 08-18-2011 |
| 20100076547 | STENT AND METHOD OF MANUFACTURING THE SAME - The present invention provides a stent that allows a simple surgical operation for affected parts of a lumen in a human body, and particularly reduces a medical side effect by contact or friction between the inside of the lumen and the outside of the stent when the stent is removed from the lumen. The stent includes a cylindrical wire structure having an internal passage and wires that are bent along the internal passage to have peaks and valleys, and a cover film that covers the wire structure. In particular, the cover film covers the wires such that the wires are embedded at the outside of the wire structure and exposed at the inside. | 03-25-2010 |
| 20100076546 | COATING FORMULATION FOR MEDICAL COATING - The invention relates to a coating formulation for preparing a medical coating, which coating formulation comprises (a) at least one multifunctional polymerizable compound according to formula (I), wherein G is a residue of a polyfunctional compound having at least n functional groups, wherein each R | 03-25-2010 |
| 20090171454 | COATED STENT AND METHODS OF MANUFACTURE - The present embodiments provide a coated stent for use in a medical procedure that comprises a coating and a stent disposed over the coating. The stent has a first expanded state in which an inner diameter of the stent is less than or equal to an outer diameter of the coating, thereby causing an inner surface of the stent to engage the outer surface of the coating. The stent may comprise a shape-memory material that is preconfigured to expand to the first expanded state. In one example, the stent may be temporarily held in a second expanded state having an inner diameter larger than the outer diameter of the coating, placed over the coating in the second expanded state, and then allowed to return to the first expanded state to engage the coating. | 07-02-2009 |
| 20090157173 | Novel Drug-Eluting Coronary Artery Stent Coated With Anti-Platelet-Derived Growth Factor Antibodies Overlaying Extracellular Matrix Proteins With an Outer Coating of Anti-Inflammatory (Calcineurin Inhibitor) and/or Anti-Proliferatives - The present invention relates to a combination of agents, including an anti-proliferative agent, an anti-inflammatory agent, an anti-growth factor, and an extracellular matrix (ECM) molecule coated on a stent to prevent acute and subacute thrombosis, enhance endothelial in-growth, and prevent neointimal hyperplasia, and/or suppress neovascularization, and thereby reduce restenosis rates for drug eluting stents. The present invention also relates to methods of using such multiple drug eluting stents for the treatment of heart disease and other vascular conditions. | 06-18-2009 |
| 20100030326 | Bioerodible Endoprosthesis - An endoprosthesis includes a plurality of struts defining a flow passage. At least one strut includes (a) a body comprising a bioerodible material and having a thickness and (b) a coating overlying the body. The coating includes a plurality of regions that allow physiological fluids to contact a plurality of corresponding areas of the underlying body when the endoprosthesis is implanted in a physiological environment. The plurality of regions are sized and arranged so that the contacted areas of the body erode substantially through the body in the thickness direction while the coating remains on the body when the endoprosthesis is implanted in the physiological environment. | 02-04-2010 |
| 20120185037 | GROOVED DRUG-ELUTING MEDICAL DEVICES AND METHOD OF MAKING SAME - The invention relates to methods and apparatus for manufacturing implantable medical devices, such as intravascular stents, wherein the medical device has a surface treated to promote the migration of endothelial cells onto the surface of the medical device. In particular, the surface of the medical device has at least one groove formed therein, the at least one groove may have a drug-eluting polymer disposed therein or a drug-eluting polymer coating may be provided on the surface of the medical device and grooves formed in the drug eluting polymer coating. | 07-19-2012 |
| 20100063585 | MANUFACTURE, METHOD AND USE OF ACTIVE SUBSTANCE-RELEASING MEDICAL PRODUCTS FOR PERMANENTLY KEEPING BLOOD VESSELS OPEN - The invention relates to stents and catheter balloons having optimized coatings for eluting rapamycin as well as methods for manufacturing these coatings. | 03-11-2010 |
| 20130046375 | PLASMA MODIFIED MEDICAL DEVICES AND METHODS - Coatings, devices and methods are provided, wherein the contacting surface of a medical device with at least one contacting surface for contacting a bodily fluid or tissue, wherein long-lasting and durable bioactive agents or functional groups are deposited on the contacting surface through a unique two-step plasma coating process with deposition of a thin layer of plasma coating using a silicon-containing monomer in the first step and plasma surface modification using a mixture of nitrogen-containing molecules and oxygen-containing molecules in the second step. The two-step plasma coating process enables the implantable medical device to prevent both restenosis and thrombosis under clinical conditions. The invention also relates to surface treatment of metallic and polymeric biomaterials used for making of medical devices with significantly improved clinical performance and durability. | 02-21-2013 |
| 20090043380 | Coatings for promoting endothelization of medical devices - A unique method and coatings are provided for promoting tissue encapsulation of medical devices, especially before antiproliferative drug therapy within a body of a patient in order to prevent excessive restenosis and while avoiding thrombosis (including late stage/stent thrombosis). The method involves delaying the activation of restenosis suppressing (i.e. antiproliferative) drugs in the vicinity of the medical device until a thin layer of geometrically streamlined tissue has deposited itself upon the device. Coatings of one or more layer that provide an aligned scaffolding (i.e. via aligned fibers or aligned grooves) may be used in the method to encourage tissue deposition and/or to delay elution of drug(s) stored beneath or within. The delay phase prior to degradation, erosion, and/or absorption of the coating to release an active drug should last until an optimal amount of controlled restenosis has provided a thin endothelial layer to encapsulate the device. | 02-12-2009 |
| 20090299468 | ENDOPROSTHESIS COATING - An endoprosthesis, e.g., a stent (e.g., a drug eluting stent), includes a surface, a first layer having a polyelectrolyte deposited on the surface, a plurality of polymeric particles deposited on the first layer, and a coating of a porous material deposited on the plurality of polymeric particles. At least one particle of the plurality of polymeric particles includes a polymer matrix and a drug distributed in the polymer matrix. A method of making the endoprosthesis is also disclosed. | 12-03-2009 |
| 20090299467 | MEDICAL IMPLANT COMPRISING A BIOLOGICAL SUBSTRATE AND A DIAMOND-LIKE CARBON COATING - Described is an implant for use in medical applications and methods of making and using the implant. The implant includes a hydrated substrate and a diamond-like carbon coating on the substrate. The substrate may be a biological substrate, such as collagen or elastin. The implant may be used to replace or restore the function of damaged tissue in a patient requiring such treatment. | 12-03-2009 |
| 20090270979 | BIODEGRADABLE METALLIC STENT - A biodegradable metal stent having delayed degradation after implantation, the stent comprising a stent material coated with at least one wax material, Also provided is a method for manufacturing and use of such a stent. | 10-29-2009 |
| 20090030509 | Stent Mandrel Fixture And Method For Reducing Coating Defects - A stent mandrel fixture for supporting a stent during the application of a coating substance is provided. | 01-29-2009 |
| 20090234442 | TEXTILE VASCULAR PROSTHESIS WITH A COATING - Textile vascular prostheses having a coating include an absorbable polymer in the form of a three-armed polyester having terminal hydroxyl groups from hydroxy acids polymerized onto a central trifunctional hydroxy compound, the three arms being tetrapolymers of lactide, ε-caprolactone, trimethylene carbonate and glycolide. The polymer is composed of about 30 to about 45 mol % of lactide, about 20 to about 40 mol % of ε-caprolactone, about 10 to about 28 mol % of trimethylene carbonate and about 10 to about 25 mol % of glycolide. | 09-17-2009 |
| 20090018647 | ENDOPROSTHESIS COATING - An endoprosthesis, such as a stent, includes a chemical tie layer formed of polymer that enhance adherence of a coating, e.g. a drug eluting polymer coating, to a stent surface, e.g. made of ceramic. | 01-15-2009 |
| 20090012608 | LIQUID AND LOW MELTING COATINGS FOR STENTS - Stents with coatings comprising a combination of a restenosis inhibitor comprising an HMG-CoA reductase inhibitor and a carrier. Also provided are methods of coating stents with a combination of an HMG-CoA reductase inhibitor and a carrier. A preferred example of a restenosis inhibitor is cerivastatin. The stent coatings have been shown to release restenosis inhibitors in their active forms. | 01-08-2009 |
| 20090240325 | Implantable Medical Device Coatings With Improved Mechanical Stability - Implantable medical device coatings that have improved mechanical stability and medical devices coated with such coatings are disclosed. | 09-24-2009 |
| 20120065727 | MECHANICALLY ATTACHED MEDICAL DEVICE COATINGS - The present invention relates to nanofibrous coatings on medical devices such a surgical mesh or stent, wherein the coating is mechanically attached to the device. The principal mechanism for attaching the coating is through causing the fibers to permeate and entangle with the substrate. | 03-15-2012 |
| 20110046724 | Expansible Biocompatible Coats Comprising a Biologically Active Substance - The present invention relates to an expansible hollow part, having at least one opening, which consists of an elastic biocompatible material and which comprises at least one biologically active substance and, optionally at least one matrix compound. The invention also provides a method of producing said expansible hollow part, a medical device covered at least partially with said hollow part, a kit-of-parts comprising said hollow part of the invention and the use of said hollow part as a therapeutic device and for protecting a medical device. | 02-24-2011 |
| 20100082097 | Article Containing Segregated Biguanide and Lewis Acid - A medical device includes a first region having a biguanide or a pharmaceutically acceptable salt thereof and a second region having a Lewis acid. | 04-01-2010 |
| 20110301695 | OPTIMUM COATINGS FOR VASCULAR STENTS - Disclosed is a stent that allows rapid coverage of the stent's luminal surface with endothelial cells while eluting enough anti-restenosis drug from the stent's abluminal surface to eliminate restenosis. A delay in the release of the anti-restenosis drug from the abluminal surface of the stent struts is created by a drug-free biodegradable polymer that covers that abluminal surface of the stent The anti-restenosis drug being only on the abluminal surface of the stent and the release of that drug being delayed by the outer polymer covering of that abluminal surface allows endothelial cells to have unconstrained mitosis so that they quickly cover the stent's luminal surface. It is further conceived to cover the luminal surface of the stent with an anti-thrombogenic coating such as carbon to further encourage endothelial cell coverage while deterring the deposition of platelets. | 12-08-2011 |
| 20110301697 | MANUFACTURE, METHOD AND USE OF DRUG-ELUTING MEDICAL DEVICES FOR PERMANENTLY KEEPING BLOOD VESSELS OPEN - The invention relates to stents and catheter balloons having optimized coatings for eluting rapamycin as well as methods for manufacturing these coatings. | 12-08-2011 |
| 20110301696 | DEVICE AND METHOD FOR MANAGEMENT OF ANEURISM, PERFORATION AND OTHER VASCULAR ABNORMALITIES - This application is directed to a device comprising a covering attached to the device. A process of making a device with a specific covering attached is also disclosed. The application further discloses a method for the treatment of perforations, fistulas, ruptures, dehiscence and aneurisms in luminal vessels and organs of a subject. | 12-08-2011 |
| 20100211164 | STENTS HAVING BIODEGRADABLE LAYERS - Provided herein is a coated coronary stent, comprising: a. stent framework; b. a plurality of layers deposited on said stent framework to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form. | 08-19-2010 |
| 20100114303 | Surface Textured Implants - Devices and methods for controlling the flaking of coating fragments from medical implants and improving the delivery of therapeutic agents from such coatings are described. | 05-06-2010 |
| 20100268330 | Methods and Devices for Implants with Calcium Phosphate - Implants with a calcium phosphate containing layer are disclosed. The implants, which can have a metallic character (e.g., made from a cobalt chromium alloy), can include a surface that is exposed to one or more formulations that results in a chemical and/or physical modification. In some instances, the modified surface is texturized so as to include a plurality of surface pits. The average pit size opening can range, for example, from 40 nm to about 10 μm, and can include a plurality of average pit sizes in some cases. The modified surfaces can promote growth of a calcium phosphate layer, which can be accelerated relative to conventional techniques. Other variations of such implant surfaces, and methods of producing similar implant surfaces, are also discussed. | 10-21-2010 |
| 20080262607 | Implant Particularly Stent, and Method For the Production of Such an Implant - An implant, particularly a stent, and a method for producing such an implant. The implant ( | 10-23-2008 |
| 20120035716 | POLYLACTIDE-COATED IMPLANT COMPOSED OF A BIOCORRODIBLE MAGNESIUM ALLOY - Some invention embodiments relate to an implant having a base body composed of a biocorrodible magnesium alloy and a polylactide coating. The implant is characterized in that the coating contains seed crystals and/or lipophilic substances as additives. | 02-09-2012 |
| 20120109287 | METHOD OF ELECTROPLATING A CONVERSION ELECTRON EMITTING SOURCE ON IMPLANT - Methods for preparing an implant coated with a conversion electron emitting source (CEES) are disclosed. The typical method includes cleaning the surface of the implant; placing the implant in an activating solution comprising hydrochloric acid to activate the surface; reducing the surface by H | 05-03-2012 |
| 20120109286 | ANTIMICROBIAL COATINGS - The present invention relates to methods for forming antimicrobial coatings, and to compounds suitable for forming the antimicrobial coatings, and to substrates coated with the antimicrobial coatings. The coatings are formed by vapour phase plasma polymerisation of metal ion complexes each having at least one polymerisable ligand, which includes a polymerisable moiety such as a C—C double bond or a C—C triple bond. | 05-03-2012 |
| 20120109285 | METHOD FOR MASS TRANSER OF MICRO-PATTERNS ONTO MEDICAL DEVICES - This invention is directed to a new method of mass-transfer/fabrication of micro-sized features/structures onto the inner diameter (ID) surface of a stent. This new approach is provided by technique of through mask electrical micro-machining. One embodiment discloses an application of electrical micro-machining to the ID of a stent using a customized electrode configured specifically for machining micro-sized features/structures. | 05-03-2012 |
| 20090012607 | METHOD FOR THE PREPARATION OF TUBE-TYPE POROUS BIODEGRADABLE SCAFFOLD HAVING DOUBLE-LAYERED STRUCTURE FOR VASCULAR GRAFT - Disclosed herein are a tube-type porous scaffold having a double-layered structure for use as an artificial vascular graft and a preparation method thereof. The method comprises (1) dissolving a biodegradable polymer in an organic solvent and mixing the polymer with a porogen so as to provide a polymer/porogen mixture; (2) coating a cylindrical shaft with the polymer/porogen mixture so as to form an inner porous coating layer; (3) preparing a biodegradable polymer gel by dissolving a biodegradable polymer in an organic solvent; (4) spinning down the biodegradable polymer gel in a non-solvent coagulation bath in which the cylindrical shaft having the inner porous coating layer, obtained at step (2), is immersed and rotated to form gel-phase fibers and allowing the gel-phase fibers to wind around the inner porous coating layer of the rotating shaft so as to form an outer polymer fibrous layer; and (5) separating the double-layered porous scaffold, formed on the shaft, from the shaft and removing the organic solvent and the porogen from the scaffold. Since the porous scaffold has a double-layered structure consisting of an inner porous coating layer containing micropores and a gel-phase outer polymer fibrous layer, it has high pore interconnectivity and mechanical strength, which effectively prevents the leakage of blood, and has high cell seeding and proliferation efficiencies, thereby being useful as a tissue-engineered artificial vascular graft. | 01-08-2009 |
| 20100125330 | SYNTHETIC VASCULAR PROSTHESIS AND METHOD OF PREPARATION - A biocompatible small-diameter vascular graft, blood vessels conduit, or cell growth stimulator carrier composition which includes a completely biodegradable, hydrophilic non-gel material that has a controllable blood absorption or other biological liquid absorption ability, a controllable fiber architecture and pore sizes, and other biologically active properties, such as cell adhesion, proliferation and spreading, haemostatic and vascular tissue growth acceleration. The material retains its contour and shape when wet, and does not exhibit any swelling. | 05-20-2010 |
| 20100087915 | Implant and Method for Manufacturing Same - The present invention relates to a method for manufacturing an implant, in particular an intraluminal endoprosthesis, with a body containing metallic material, preferably iron. To control the degradation of the implant, the method comprises the following steps: a) preparing the body of the implant, and b) incorporating hydrogen into at least a portion of the structure of the implant body near the surface. Furthermore, such an implant is described. | 04-08-2010 |
| 20110022162 | ENDOPROSTHESES - An endoprosthesis includes an endoprosthesis wall that includes a ceramic coating and a polymer coating containing a therapeutic agent. A ceramic coating can be formed on the wall by electrochemical deposition. Cyclic voltammetry can be conducted to modify the density of the hydroxyl groups on the surface of the ceramic coating. | 01-27-2011 |
| 20090062910 | STENT WITH DIFFERENTIAL TIMING OF ABLUMINAL AND LUMINAL RELEASE OF A THERAPEUTIC AGENT - The invention relates generally to a medical device that is useful for delivering a therapeutic agent to the body tissue of a patient, and the method for making such a medical device. More particularly, the invention is directed to a stent having a tubular sidewall with a first coating composition on at least the luminal surface and/or abluminal surface, and a second coating composition disposed on at least a portion of the first coating composition comprising a low diffusivity biodegradable polymer. | 03-05-2009 |
| 20080281410 | Method for Production of a Coated Endovascular Device - A method of coating a endovascular device that includes coating of a tubular body's surface by at least a thin layer (s) of a inert and biocompatible titanium based material. This method is performed by the following steps in succession: Deposition of a first Titanium layer ( | 11-13-2008 |
| 20090319034 | METHOD OF DENSIFYING ePTFE TUBE - The present invention relates to a prosthetic structure, including a densified layer of expanded polytetrafluoroethylene (ePTFE) and a method for manufacturing the same. The invention includes the steps of providing a layer of ePTFE, desirably a tubular layer; applying the layer of ePTFE to a mandrel; mechanically compressing the layer of ePTFE on the mandrel; and removing the compressed ePTFE; where the compressed ePTFE is denser than uncompressed ePTFE. The compressed ePTFE has a water entry pressure (WEP) value of at least 15 psi, and desirably a WEP of at least about 20 psi. | 12-24-2009 |
| 20080281409 | STENTS WITH DRUG ELUTING COATINGS - Provided is a coated medical device (e.g., a stent) comprising one or more surfaces having dispersed thereon a plurality of microparticles comprising an active pharmaceutical ingredient (API) and a polymer. Specifically, the microparticles are disposed on a device surface in a microparticulate phase coating, i.e., as discrete microparticles in the absence of a continuous phase coating. The medical device effectively adheres one or more APIs to its surface, and allows controlled release of the APIs from the device surface to a desired treatment area by using a minimal amount of polymer. The medical device is suitable for insertion or implantation into a subject, preferably a human. Also provided are methods for preparing and using the coated medical device. | 11-13-2008 |
| 20080275547 | INTRAVASCULAR, INDWELLING INSTRUMENT - An intravascular, indwelling instrument for placement in a blood vessel includes a body having a face in contact with a maintained blood flow to be maintained and a face in contact with a non-maintained blood flow not to be maintained, and a peptide fixed to all or part of the maintained blood flow contact face or the non-maintained blood flow contact face of the body. The peptide has specific interaction with vascular endothelial precursor cells, with the peptide permitting selective adsorption and adhesion of the vascular endothelial precursor cells to cover all or part of the maintained blood flow contact face or the non-maintained blood flow contact face of the body with the vascular endothelial precursor cells thereby reducing or inhibiting the blood flow not to be maintained. | 11-06-2008 |
| 20080275545 | Method and Device for Investigation of Sludge Deposits on Materials for Endoprostheses and Endoprosthesis - The invention relates to a method and device for the investigation of sludge deposition on materials for coating endoprostheses. At least one endoprosthesis is placed in an incubation chamber which is at least partly filled with infected bile. The incubation chamber is rocked gently on a rocking platform for a period of about 35 days. The bile fluid is regularly partly exchanged. The endoprosthesis is embodied in a coated plastic. The coating comprises 70 to 80% by weight of hydrophobic components and 30% to 20% by weight of hydrophilic components. The coating may particularly have a sol-gel embodiment. An application in bile duct prostheses is possible. | 11-06-2008 |
| 20110270387 | Implantable Medical Devices Comprising Poly[L-Lactide-Co-(3,6-Dialkyl-1,4-Dioxane-2,5-Dione)] - This invention is directed to implantable medical device comprising a polymeric composition comprising poly[L-lactide-co-(3,6-dialkyl-1,4-dioxane-2,5-dione)], alone or as a blend with one or more polymers selected from the group consisting of poly(L-lactide) and poly(3,6-dialkyl-1,4-dioxane-2,5-dione). | 11-03-2011 |
| 20090030508 | Stent Mandrel Fixture And Method For Reducing Coating Defects - A stent mandrel fixture for supporting a stent during the application of a coating substance is provided. | 01-29-2009 |
| 20090030507 | DEGRADABLE METAL STENT HAVING AGENT-CONTAINING COATING - A stent comprising a degradable metal stent main body; a partition layer which is applied to the surface of the stent main body so that at least parts of the surface of the luminal side are not covered; and an agent-containing layer which is applied to the surface of the partition layer at least partially on the abluminal side of the stent main body and comprises one or more agents and possibly one or more polymers. | 01-29-2009 |
| 20090005861 | STENT COATINGS WITH ENGINEERED DRUG RELEASE RATE - Coatings and methods of forming coatings for implantable medical devices, such as stents, are described. The coatings are used for the sustained release of a therapeutic agent or drug. | 01-01-2009 |
| 20090177273 | ANISOTROPIC NANOPOROUS COATINGS FOR MEDICAL IMPLANTS - The present invention relates to a process for fabricating a porous coatings with controlled structure in the micro and nano-size domain. In particular, but not exclusively, it relates to a process for fabricating coatings with an anisotropic pore size distribution and to coatings obtained using such coatings. It describes in particular the use of ink-jet method to deposit in a controlled way such coatings. It also relates to porous coatings with controlled structure in the micro and nano-size domain. The coating has a thickness between 10 nanometers and 10 millimeters and its porosity is created in such a way that the pore size distribution is anisotropic. It finally describes objects covered with this coating. | 07-09-2009 |
| 20090326646 | Methods and Apparatus for Multiple Cured Formulation Coated Stents - The methods and apparatus of the present disclosure in a broad aspect provide stents with multiple cured formulations. Selective curing of formulations on a stent framework, such as by ultraviolet light, results in stents having multiple cured formulations as coatings which may or may not be layered in uniform or non-uniform fashion. | 12-31-2009 |
| 20110224783 | ENDOPROSTHESIS COATING - An endoprosthesis, such as a stent, includes anchoring regions formed of polymer that enhance adherence of a coating, e.g. a drug eluting polymer coating, to a stent surface, e.g. made of ceramic. The anchoring regions can be formed using stamping processes. | 09-15-2011 |
| 20110144741 | Coating Construct With Enhanced Interfacial Compatibility - The present invention provides a method of forming a coating on a medical device having a topcoat and a basecoat and an improved compatibility between a topcoat and a basecoat on the medical device. | 06-16-2011 |
| 20090192596 | IMPLANT HAVING A BASE BODY OF A BIOCORRODIBLE ALLOY - An implant having a base body comprised entirely or partially of a biocorrodible metallic material and in which at least the parts of the base body comprising the biocorrodible metallic material are covered entirely or partially with a coating which contains or is comprised of the polymer. At least 90% of the total number of polymer units of the polymer comprise polymer units of formula (1) and polymer units of formula (2) | 07-30-2009 |
| 20120078349 | COATED IMPLANT COMPOSED OF A BIOCORRODIBLE MAGNESIUM ALLOY - One embodiment of the invention relates to a coated implant having a base body composed of a biocorrodible magnesium alloy. The coating of the implant comprises: | 03-29-2012 |
| 20090099652 | Composite Vascular Prosthesis - A novel treatment for atherosclerotic vascular disease is described utilizing the implantation of a thin, conformable biocompatible prosthesis constructed from a composite of various structural and therapeutic scaffolds in combination with one or more bioactive agents. This prosthesis can be delivered into position over a lesion in order to passivate atherosclerotic plaques with minimal remodeling of the artery, or alternatively can be applied with a balloon to passivate the remodeled site. The composite prosthesis itself provides mild structural reinforcement of the vessel wall and an evenly distributed platform for the introduction of bioactive therapeutic agents. | 04-16-2009 |
| 20100152842 | Implant Comprising a Biotoxic Coating and Method for the Production Thereof - Disclosed is a method for producing an implant coating that has a defined toxicity. The method is characterized by the following steps: i. a sol is produced from a biotoxic solution containing precious metal ions and a precursor solution for a titanium oxide; ii. an implant is coated by applying the sol in a sol-gel process; iii. the coating is pyrolyzed and sintered without admitting any light, the precious metal ion concentration in the dried coating ranging from 10 to 60 percent relative to the total weight of the dried coating; and iv. at least subareas of the coating produced without admitting any light are illuminated in order to reduce the toxicity of the dried coating to a predetermined measure. | 06-17-2010 |
| 20100191324 | ENDOPROSTHESIS AND METHOD FOR MANUFACTURING SAME - An endoprosthesis, in particular an intraluminal endoprosthesis, for example a stent, having a basic mesh composed of an at least predominantly biodegradable material, and a coating provided on the biodegradable material is proposed. For better control of the degradation the basic mesh is essentially completely covered by a coating which contains parylene, preferably at least predominantly parylene, particularly preferably parylene C or parylene N, and the basic mesh is essentially completely covered by the coating, whereby the thickness of the coating is between approximately 0.1 μm and approximately 10 μm, preferably between approximately 0.4 μm and approximately 7 μm, particularly preferably between approximately 1 μm and approximately 5 μm. Also proposed is a method for manufacturing such an endoprosthesis. | 07-29-2010 |
| 20080215140 | STENTS COATED WITH BIOMOLECULES AND PROCESS FOR THEIR PRODUCTION - A stent comprising a basic stent body, at least one anchor group on the surface of the basic stent body, and at least one biomolecule which is bound to the at least one anchor group, the anchor group being the same or different and selected from the group of compounds with the general formula (I) | 09-04-2008 |
| 20120197387 | STENT WITH INTERNAL FORCE AND FABRICATION METHOD THEREOF - A stent includes: a main body unit including a plurality of through holes and configured to have a net-like shape; and a coating unit filling the through holes of the main body unit and configured as a layer on the main body unit, wherein the main body unit has force of restitution to be restored to its original shape, and the coating unit includes a support unit for maintaining the shape of the main body unit by hampering the restoration of the main body unit and a blocking unit blocking the through holes of the main body unit to discriminate the interior and the exterior of the main body unit. The stent can be quickly expanded in a blood vascular system, or the like, after being inserted into the body in a surgical procedure, thus improving expansion (or extension) effect. | 08-02-2012 |
| 20110112629 | IMPLANTABLE MEDICAL DEVICES WITH FLUORINATED POLYMER COATINGS, AND METHODS OF COATING THEREOF - An implantable medical device including an expandable stent with an amorphous fluoropolymer coating, and methods of coating the stent. The amorphous fluoropolymer coating may be optically transparent and resistant to chemical corrosion. | 05-12-2011 |
| 20090076596 | STENT HAVING A COATING - A stent having a coating comprising either L-3,4-dihydroxyphenylalanine (L-DOPA) or a derivative of L-3,4-dihydroxyphenylalanine (L-DOPA), the foregoing obtained by either ionic or covalent bonding of a pharmaceutical active ingredient to either the amino or the acid function of L-3,4-dihydroxyphenylalanine (L-DOPA). | 03-19-2009 |
| 20110238162 | MEDICAL IMPLANT - Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties. | 09-29-2011 |
| 20100137978 | Medical Implants Including Iridium Oxide - A medical implant includes iridium oxide. The iridium oxide has a plurality of Ir—O σ bonds and a plurality of Ir═O σ bonds. The iridium oxide has a ratio of the Ir—O σ bonds to the Ir═O π bonds that is greater than 1.3. | 06-03-2010 |
| 20090248146 | COATINGS FOR IMPLANTABLE MEDICAL DEVICES - Coatings for implantable medical devices comprising non-fouling moieties or polymers chemically bonded to the surface of the device via chelating structures, and methods of fabricating the coatings are disclosed. | 10-01-2009 |
| 20120143318 | IMPLANT MADE OF A METALLIC MATERIAL WHICH CAN BE RESORBED BY THE BODY - The invention relates to an implant consisting of a metallic magnesium alloy that can be resorbed by the body, said metallic material being a magnesium alloy consisting of at least 96% w/w of magnesium, at least 1% w/w of manganese and at least 0.5% w/w of at least one metal of the rare earth group. | 06-07-2012 |
| 20100100172 | Stent Coating For Eluting Medication - A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment. | 04-22-2010 |
| 20100198345 | CALCIUM PHOSPHATE COATED IMPLANTABLE MEDICAL DEVICES, AND ELECTROPHORETIC DEPOSITION PROCESSES FOR MAKING SAME - This invention relates to novel calcium phosphate coated implantable medical devices, and electrophoretic deposition processes for making same. A process of coating an implantable medical device with a calcium phosphate coating comprising: (a) pretreating a substrate with an alkaline solution; (b) preparing a slurry comprising a solvent and a defined size range of calcium phosphate particles; (c) immersing the pretreated substrate in the slurry; and (d) coating the calcium phosphate particles onto the pretreated substrate by electrophoretic deposition. | 08-05-2010 |
| 20110060402 | Wettable ePTFE Medical Devices - Methods are provided for surface modifying a hydrophobic polymer substrate to increase wettability comprising the steps of pre-treating the hydrophobic polymer substrate with a radio frequency (RF)-generated first plasma and a RF-generated second plasma wherein the first plasma and the second plasma are applied sequentially, coating the hydrophobic polymer substrate with a hydrophilic coating; and polymerizing the hydrophilic coating on the hydrophobic polymer substrate by exposure to a RF-generated third plasma. | 03-10-2011 |
| 20110238161 | SYSTEM AND METHOD FOR ENHANCED ELECTROSTATIC DEPOSITION AND SURFACE COATINGS - This disclosure describes the application of a supplemental corona source to provide surface charge on submicrometer particles to enhance collection efficiency and micro-structural density during electrostatic collection. | 09-29-2011 |
| 20100312331 | POLYMER COATINGS ON MEDICAL DEVICES - A medical device, for example a stent, has a surface which in use contacts body tissue, wherein said surface has on it a biocompatible coating layer comprising a polymer having covalently bound allyl-terminated pendent groups, said pendent groups comprising a moiety selected from -0-CH | 12-09-2010 |
| 20110029070 | ADHESION PROMOTING PRIMER FOR COATED SURFACES - An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized. | 02-03-2011 |
| 20090069884 | STENT HAVING A BASE BODY OF A BIOCORRODABLE ALLOY - A stent comprising a base body consisting at least in part of either an arsenic-containing or selenium-containing biocorrodable alloy of at least one element selected from the group consisting of magnesium, iron, tungsten, zinc and molybdenum. A method for producing a stent with a base body having a core and a diffusion layer covering the core and an arsenic-containing and/or selenium-containing biocorrodable alloy comprising at least one element selected from the group consisting of magnesium, iron, tungsten, zinc and molybdenum. | 03-12-2009 |
| 20100131052 | METHOD FOR PRODUCING A CORROSION-INHIBITING COATING ON AN IMPLANT MADE OF A BIOCORRODIBLE MAGNESIUM ALLOY AND IMPLANT PRODUCED ACCORDING TO THE METHOD - The invention relates to a method for producing corrosion-inhibiting coatings on an implant made of a biocorrodible magnesium alloy and to implants obtained or obtainable according to the method. | 05-27-2010 |
| 20100131051 | Systems and Methods for Treatment of Aneurysms Using Zinc Chelator(s) - Disclosed herein are methods and stent graft configurations related to the treatment of aneurysms through the local administration of zinc chelator(s). The zinc chelator(s) can be locally administered by placing one or more of them directly onto a stent graft, incorporating them into a coating found on a stent graft, including them in a delivery device that is associated with a stent graft, and/or injecting them through delivery and/or injection catheters at or near the time of stent graft deployment. | 05-27-2010 |
| 20110153005 | MEDICAL IMPLANT, COATING METHOD AND IMPLANTATION METHOD - One example of the invention relates to a medical implant having a base body comprising a first end and a second end, which are arranged at opposite ends of the base body in a main direction of the extent of the base body, and a coating, such that the coating has at least one active substance with an active substance gradient. It is proposed that the quantity of active substance shall decrease from the first end to the second end, at least in the main direction of extent of the base body. | 06-23-2011 |
| 20110153007 | Taxane Coatings for Implantable Medical Devices - This disclosure relates to implantable medical devices coated with a taxane therapeutic agent, such as paclitaxel, in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous and/or solvated solid forms of taxane therapeutic agents that provide durable coatings that release the taxane over a desired period of time, which can be varied in the absence of a polymer by selecting the type and amount of solid forms of the taxane therapeutic agent in the coating. Other preferred embodiments relate to methods of coating medical devices and methods of treatment. The coatings can provide a sustained release of the taxane therapeutic agent within a body vessel without containing a polymer to achieve the desired rate of paclitaxel elution. | 06-23-2011 |
| 20110034996 | MEDICAL IMPLANT CONTAINING AN ANTIOXIDATIVE SUBSTANCE - One embodiment of the invention concerns a medical implant with the basic body having an antioxidative substance. | 02-10-2011 |
| 20110029069 | Bioactive Material Coating Method And Tube - A method for coating bioactive material and a structured coated with a bioactive material are disclosed. The bioactive material coating method includes: flowing a coating solution, produced as a bioactive material is dissolved in a mixed solvent, inside a structure having a lumen; and coating the bioactive material on at least one of inner and outer surfaces of the structure, with different concentrations. The mixed solvent is mixed with two or more solvents having different features. The occurrence of the strangulation of blood vessels and inflammation can be reduced. An increase in the size of the myofibroblast is not suppressed. The coating solution is produced as a medication is dissolved in a mixed solvent, where the mixed solvent is produced as a polar solvent and a nonpolar solvent are mixed with each other at a certain ratio. | 02-03-2011 |
| 20110015725 | COATED MEDICAL DEVICE - A coated medical device ( | 01-20-2011 |
| 20110178595 | POLYMER COATING FOR MEDICAL DEVICES - Coatings are provided in which surfaces may be activated by covalently bonding a combination of silane derivatives (A) to the metal surface, covalently bonding a lactone polymer (B) to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester (C) on the bonded lactone polymer. Biologically active agents or therapeutic compounds may be deposited with any of the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents. | 07-21-2011 |
| 20100262230 | Automated Coating Apparatus and Method - An automated apparatus and method for coating medical devices such as an intravascular stent, are disclosed in the method, a 2-D image of a stent is processed to determine (1) paths along the stent skeletal elements by which a stent secured to a rotating support element can be traversed by a dispenser head whose relative motion with respect to the support element is along the support-element axis, such that some or all of the stent skeletal elements will be traversed (2) the relative speeds of the dispenser head and support element as the dispenser head travels along the paths, and (3), and positions of the dispenser head with respect to a centerline of the stent elements as the dispenser head travels along such paths The rotational speed of the support and relative linear speed of the dispenser are controlled to achieve the desired coating thickness and coating coverage on the upper surfaces, and optionally, the side surfaces, of the stent elements | 10-14-2010 |
| 20100262229 | Endoprosthesis and Method for Manufacturing Same - The invention relates to intraluminal endoprosthesis, preferably a stent consisting essentially of a base body and optionally a coating covering the surface of the base body at least partially. The invention is characterized in that the base body and/or the coating has at least one compound from the group of polyphosphates, magnesium oxyhalides, preferably Sorel cement. Furthermore, a method is described for manufacturing such an intraluminal endoprosthesis. | 10-14-2010 |
| 20100057200 | VASCULAR STENT - In order to provide a vascular stent, with which the risk of restenosis is reduced without having to use anti-proliferative active substances, there is proposed a carrier of a dimensionally stable material, as well as one or more layers, which are disposed at least in sections on the carrier, of a material based on crosslinked gelatin that is resorbable under physiological conditions, wherein the adhesion between the carrier and the layer and/or between individual layers can be neutralised. | 03-04-2010 |
| 20080243242 | METHOD FOR PRODUCING A CORROSION-INHIBITING COATING ON AN IMPLANT MADE OF A BIO-CORRODIBLE MAGNESIUM ALLOY AND IMPLANT PRODUCED ACCORDING TO THE METHOD - A method for producing a corrosion-inhibiting coating on an implant made of a biocorrodible magnesium alloy, the method comprising providing the implant; and treating the implant surface using an aqueous or alcoholic conversion solution containing one or more ions selected from the group consisting of K | 10-02-2008 |
| 20080312736 | IMPLANT HAVING A SURFACE-PROXIMAL MAGNESIUM-CONTAINING DIFFUSION LAYER AND ASSOCIATED PRODUCTION METHOD - An implant comprising an implant material forming a base made of one or more metallic elements; a diffusion layer covering the base made of at least one of the metallic elements of the implant material and at least magnesium; and, optionally, a metal layer covering the diffusion layer made of magnesium or a biocorrodible magnesium alloy. | 12-18-2008 |
| 20110257732 | STENTS HAVING CONTROLLED ELUTION - Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form. | 10-20-2011 |
| 20080215141 | Coating for a Stent and a Method of Forming the Same - A coating for a stent and methods for coating a stent are provided. The coating may be used for the sustained delivery of an active ingredient or a combination of active ingredients. | 09-04-2008 |
| 20100280601 | Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof - The invention relates to a method for precipitating mono or multiple layers of a mixture of organophosphoric acids of the general formula I (A) | 11-04-2010 |
| 20110022161 | IODINATED POLYMERS - The invention provides medical devices that comprise an iodinated polymer and that can be viewed using X-Ray imaging techniques. The invention also provides novel iodinated polymers that can be incorporated into or coated on medical devices. | 01-27-2011 |
| 20110118827 | Biodegradable stent formed with polymer-bioceramic nanoparticle composite and method of making the same - The present invention relates to biodegradable medical devices such as stents manufactured from biodegradable polymeric-bioceramic nanoparticle composites. The invented medical devices include at least one bioceramic nanoparticle dispersed in at least one biodegradable polymer, wherein the said biodegradable polymers include biodegradable polyesters. The device and methods to disperse one or more bioceramic nanoparticle, wherein the said bioceramic nanoparticle include, but are not limited to, amorphous calcium phosphate (ACP), dicalcium phosphate (DCP), tricalcium phosphate (TCP), pentacalcium hydroxyl Apatite (HAp), tetracalcium phosphate monoxide (TTCP) and combinations or analogues thereof. Other embodiments include methods of fabricating biodegradable stent with said polymeric-nanoparticle composites. | 05-19-2011 |
| 20110118826 | Bioerodible Endoprosthesis - An endoprosthesis includes a plurality of struts defining a flow passage. At least one strut includes (a) a body comprising a bioerodible material and having a thickness and (b) a coating overlying the body. The coating includes a plurality of regions that allow physiological fluids to contact a plurality of corresponding areas of the underlying body when the endoprosthesis is implanted in a physiological environment. The plurality of regions are sized and arranged so that the contacted areas of the body erode substantially through the body in the thickness direction while the coating remains on the body when the endoprosthesis is implanted in the physiological environment. | 05-19-2011 |
| 20110118825 | ANTI-ANGIOGENIC COMPOSITIONS AND METHODS OF USE - The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions. | 05-19-2011 |
| 20110125255 | PTFE LAYERS AND METHODS OF MANUFACTURING - Single, continuous PTFE layers having lateral zones of varied characteristics are described. Some of the lateral zone embodiments may include PTFE material having little or no nodal and fibril microstructure. Methods of manufacturing PTFE layers allow for controllable permeability and porosity of the layers, in addition to other characteristics. The characteristics may vary from one lateral zone of a PTFE layer to a second lateral zone of a PTFE layer. In some embodiments, the PTFE layers may act as a barrier layer in an endovascular graft or other medical device. | 05-26-2011 |
| 20100191325 | COATING CONTAINING PEGYLATED HYALURONIC ACID AND A PEGYLATED NON-HYALURONIC ACID POLYMER - Provided herein re a composition and a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof. | 07-29-2010 |
| 20110153006 | Biocorrodible implants having a functionalized coating - One example embodiment of the present invention relates to an implant comprising a biocorrodible metallic material and having a coating, characterized in that the coating contains at least one layer in which ionic channels are embedded. | 06-23-2011 |
| 20090030506 | ENDOPROSTHESIS AND METHOD FOR MANUFACTURING SAME - A stent with a basic mesh comprising an at least largely biodegradable material and a coating ( | 01-29-2009 |
| 20080275546 | Inhibitory cell adhesion surfaces - Textured nanostructured surfaces are described which are highly resistant to cell adhesion. Such surfaces on medical implants inhibit fibroblast adhesion particularly on titanium treated silicone. The surfaces can also be engineered so that other cell types, such as endothelial and osteoblast cells, show little if any tendency to attach to the surface in vivo. | 11-06-2008 |
| 20110307054 | IMPLANT COATING WITH NUCLEIC ACIDS - One example embodiment of the present invention relates to an implant with a coating or a cavity filling containing a nucleic acid, which i) can inhibit the expression of at least one representative of the Ras gene family by means of RNA interference; or ii) encodes for a nucleic acid that can inhibit the expression of at least one representative of the Ras gene family by means of RNA interference. | 12-15-2011 |
| 20100305689 | Non-Biodegradable Stent Comprising a Biodegradable Coating and Method of Coating The Same - The present invention relates to the field of non-biodegradable stents, and therein to non-biodegradable stents coated with at least one layer of a biodegradable polymer which maintains mechanical integrity of the coating both in storage and upon balloon expansion and which can optionally release drugs. The at least one polymer layer comprises a biodegradable polymer and a plasticizer. The present invention also relates to a manufacturing method of such a non-biodegradable stent. | 12-02-2010 |
| 20120041545 | PRIMER FOR COATING COILED WIRES - Disclosed is a method to provide a metal wire with a coating system comprising a primer and a topcoat, particularly a hydrophilic, lubricious topcoat. The method comprises applying directly onto the wire metal a primer coating composition, which is an aqueous coating composition comprising a multiphase vinyl polymer, the polymer comprising a first phase having a Tg in the range of from −20° C. to 40° C. and a hard phase having a Tg in the range of from 25° C. to 120° C. The primer has good adhesion to both the metal surface and the topcoat, and provides the eventual coating system with, inter alia, a good flexibility. | 02-16-2012 |
| 20110112628 | IMPLANT AND METHOD FOR MANUFACTURING SAME - An implant, in particular an intraluminal endoprosthesis, is provided having an implant body containing biodegradable metallic material, preferably iron. To accelerate the degradation, at least a portion of the surface of the implant body has a first coating formed from a composition containing at least one element selected from the group including strontium and calcium. An inexpensive method for manufacturing such an implant is also described. | 05-12-2011 |
| 20120041546 | MEDICAL DEVICES HAVING ACTIVATED SURFACES - Implantable biocompatible polymeric medical devices include a substrate with a plasma-modified surface which is subsequently modified to include click reactive members. | 02-16-2012 |
| 20120150286 | BIOERODIBLE ENDOPROSTHESIS WITH BIOSTABLE INORGANIC LAYERS - Medical devices such as endoprostheses (e.g., stents) containing one or more biostable layers (e.g., biostable inorganic layers) and a biodegradable underlying structure are disclosed. | 06-14-2012 |
| 20120150285 | MEDICAL DEVICES CONTAINING DRY SPUN NON-WOVENS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS - Continuous processing methods for making absorbable polymeric dry spun non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 0.01 μm to 50 μm, and thickness from 10 μm to 10 mm, have been developed. Improved fiber cohesion is made possible by controlling the tackiness of the fibers of the non-woven during web collection. The polymer is preferably a polyhydroxyalkanoate, more preferably, a 4-hydroxybutyrate polymer or copolymer. A non-woven of poly-4-hydroxybutyrate is most preferred. The non-wovens have fine fibers with average diameters ranging from 0.01 μm to 50 μm, and are derived by dry spun processing, during which a solution of polymer(s) is injected into a stream of high velocity air with a pressure of 1 to 500 psi for solvent stripping and polymer strand attenuation. The non-wovens can be used for a variety of purposes including fabrication of medical devices. | 06-14-2012 |
| 20090270978 | COATED EMBOLIZATION DEVICE - Described are embolization devices having unique bioactive coatings, as well as methods for their manufacture and use. An illustrative embolization device of the invention comprises an embolic body and a coating material comprising biotropic extracellular matrix material immobilized on a surface of the embolic body. The biotropic extracellular matrix material comprises a network of self-assembled collagen fibrils, and comprises at least one bioactive agent retained in the extracellular matrix material, wherein the bioactive agent is selected from the group consisting of a proteoglycan, a growth factor, a glycoprotein, and a glycosaminoglycan. In certain forms, such an extracellular matrix material comprises a remodelable, angiogenic extracellular matrix material, for example, a submucosa material such as but not limited to porcine small intestinal submucosa. | 10-29-2009 |
| 20120046737 | MEDICAL DEVICES HAVING ACTIVATED SURFACES - Implantable biocompatible polymeric medical devices include a substrate with an acid or base-modified surface which is subsequently modified to include click reactive members. | 02-23-2012 |
| 20090319035 | ANTIMICROBIAL COATING - Described herein are coatings containing water-soluble oligodynamic metal salts that are formulated and applied from hydrophobic solvents. In particular, articles of manufacture comprising polymer coatings containing oligodynamic metal salts can include hydrophobic polymer coatings made from water-reactive monomers and hydrophilic polymers compounded in hydrophobic solvents which contain a small amount of water that aids in the solubilization and suspension of the oligodynamic metal salts. Methods of preparing these antimicrobial polymer coatings, and methods of coating a substrate to produce an article of manufacture having an antimicrobial polymer coating are also described. | 12-24-2009 |
| 20120046735 | PLASMA MODIFICATION OF METAL SURFACES - The present invention provides modified metal surfaces, methods of preparing the same, and intermediates thereto. These materials are useful in a variety of applications including biomaterials. | 02-23-2012 |
| 20120004721 | METHODS TO IMPROVE ADHESION OF POLYMER COATINGS OVER STENTS - Methods are disclosed to improved adhesion of polymer coatings over polymer surfaces of stents which include plasma treatment, applying an adhesion promoting layer, surface treatments with solvents, and mechanical roughening techniques. | 01-05-2012 |
| 20110040372 | Coated Endoluminal Implant - A stent structure ( | 02-17-2011 |
| 20120046736 | SURFACE TEXTURED IMPLANTS - Devices and methods for controlling the flaking of coating fragments from medical implants and improving the delivery of therapeutic agents from such coatings are described. | 02-23-2012 |
| 20100286765 | Medical Device Coatings and Coated Stents - The invention provides a medical device coated with Ap | 11-11-2010 |
| 20110166647 | IMPLANTABLE MEDICAL DEVICE - The invention provides an implantable medical device comprising a fibrous polymer body comprising a plurality of electrospun poly(urethane) fibers, a support filament wrapped around the body, an outer layer around the filament for adhering the filament to the body, the outer layer comprising a plurality of electrospun poly(urethane) fibers, and a polymer primer coating at least the fibers of the body. The polymer primer comprises poly(lactide) and is attached to a heparin residue through a link. | 07-07-2011 |
| 20120116502 | SURFACE TEXTURED IMPLANTS - Devices and methods for controlling the flaking of coating fragments from medical implants and improving the delivery of therapeutic agents from such coatings are described. | 05-10-2012 |
| 20120116503 | COATED MEDICAL DEVICES AND METHODS - The invention relates to medical device systems that include a delivery instrument comprising a sheath having an abluminal surface and a luminal surface; a radially-expandable frame disposed at least partially within the sheath, the frame having an abluminal surface at least partially in contact with the luminal surface of the sheath, and a luminal surface defining a sub-stantially cylindrical lumen; and a fine powder coating disposed on at least one of the abluminal surface of the frame and the luminal surface of the sheath. The invention also relates to methods of manufacturing, loading, and delivering the coated medical devices. | 05-10-2012 |
| 20090138077 | Articles having ceramic coated surfaces - According to an aspect of the invention, articles are provided which comprise a substrate and a ceramic coating which covers at least a portion of the substrate surface. The ceramic coating includes raised ceramic shells connected by a ceramic layer that is conformal with the substrate. According to another aspect of the present invention, carbon nanotubes are provided, which comprise a ceramic coating covering at least a portion of the carbon nanotubes. | 05-28-2009 |
| 20090287302 | Polymer coated spinulose metal surfaces - Spinulose surfaces such as titanium and zirconium can be coated with a range of polymers used to form thin, adherent polymer surface films. Selected polymer coatings are useful for use as biocompatible surfaces on implants, catheters, guidewires, stents and a variety of medical devices for in vivo applications. The polymer coatings can also be used to protect metal surfaces nanostructured with spinulose titanium or zirconium. | 11-19-2009 |
| 20120059456 | MODIFICATION OF STENT SURFACES TO IMPART FUNCTIONALITY - In one aspect, the invention relates to coated substrates comprising a substrate having a surface, a cationic polymer layer adjacent the surface of the substrate, an anionic polymer layer adjacent the cationic polymer layer and methods for producing and using same. In one aspect, the cationic polymer layer comprises at least one residue of a first compound having the structure: | 03-08-2012 |
| 20090018648 | STENT WITH A COATING - A stent of a metallic base body with a selenium-containing coating or filling of a cavity. | 01-15-2009 |
| 20120158127 | BIOABSORBABLE AND BIOCOMPATIBLE POLYURETHANES AND POLYAMIDES FOR MEDICAL DEVICES - Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: | 06-21-2012 |
| 20120071967 | ONE-STEP PHOSPHORYLCHOLINE-LINKED POLYMER COATING AND DRUG LOADING OF STENT - A one step method for drug coating an interventional device is disclosed by mixing a drug with a phosphorylcholine-linked methacrylate polymer in a liquid and applying the mixture to an interventional device, such as a stent, in a single step. | 03-22-2012 |
| 20110066230 | Fluorinated GHRH Antagonists - Novel fluorinated synthetic analogs of hGH-RH(1-30)NH | 03-17-2011 |
| 20110066229 | COATED IMPLANT - Implant provided with a coating, with the implant being provided with an amino-functionalized parylene coating, an oligonucleotide and/or an oligopeptide having a specific bonding affinity with CD34-positive cells. | 03-17-2011 |
| 20110106243 | Coating Method for Medical Devices - The invention relates to a method for coating medical devices with a biocompatible protein coating. | 05-05-2011 |
| 20100094409 | IMPROVEMENTS IN AND RELATING TO MEDICAL DEVICES - An endoluminal prosthesis is provided for use in the treatment of a dilation in a body vessel. This dilation might be an abdominal aortic aneurysm or a dilation in a blood vessel wall following a balloon angioplasty procedure. The prosthesis comprises a radially expandable tubular member and a covering provided on the outer surface of the tubular member. The covering comprises first and second layers of material. The first layer comprises an agent that promotes swelling of the covering on exposure of the covering to contact with body fluid, such as blood. The second layer comprises space-filling material. When the prosthesis is delivered into the body vessel the tubular member can automatically expand or be expanded radially. The covering will also swell on the tubular member. This expansion and swelling forces the exterior of the swollen covering into intimate sealing contact with the surrounding inner wall of the vessel. When used in the treatment of an aneurysm this can provide significant advantages in eliminating or reducing primary endoleak. | 04-15-2010 |
| 20100094410 | COATED IMPLANT - The present invention relates to an implant or a part thereof coated with polylactide. | 04-15-2010 |
| 20100249914 | Sustained drug-releasing stent - A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight. | 09-30-2010 |
| 20120130482 | VASCULAR STENTS - The disclosure describes a coating for medical implants, in particular, vascular stents, said coating comprising silicon dioxide, towards medical implants with a coating containing silicon dioxide and towards a method for their production. The coating can contain additional admixtures and have functionalization coats. The substrate of the coating is produced from a durable material, preferably from a stainless steel. | 05-24-2012 |
| 20120130483 | TUBULAR IMPLANT FOR REPLACING NATURAL BLOOD VESSELS - A tubular implant that replaces natural blood vessels includes a prefabricated vascular prosthesis with an internal surface, an external surface and a wall, wherein the internal and/or external surface of the prefabricated vascular prosthesis has a polyurethane coating. | 05-24-2012 |
| 20100049310 | METHOD FOR COATING A STENT - Method for applying a coating layer to a tubular intraluminal implant, in particular to a vascular support (stent), where the surface of the implant is perforated by a plurality of apertures, and where the coating layer is produced by deposition of material onto the surface of the implant. The implant is first pushed onto a cylindrical holder | 02-25-2010 |
| 20120239140 | MEDICAL PRODUCT COMPRISING AN ACTIVE COATING - An embodiment of the present invention relates to a medical product coated with a polymer layer, which comprises an inhibitor of the TRPC-3 ion channel underneath, in, and/or on the biostable or biodegradable polymer layer. | 09-20-2012 |
| 20110238163 | Multi-layered Device - There is provided a device comprising a body structure having one or more surfaces wherein at least one of the surfaces comprises a pH sensitive layer comprising a linear polymer, wherein the water solubility of the linear polymer increases from a first water solubility to a second water solubility at a pH trigger. A method of forming a device, and a method of preventing or mitigating infection is also described. | 09-29-2011 |
| 20120095548 | MEDICAL IMPLANT INCLUDING A MAGNESIUM-BASED TIE LAYER - A medical implant includes a metallic base, a tie layer, and at least a first layer overlying an outer surface of the tie layer. The tie layer is bonded to at least a portion of a surface of the metallic base. The tie layer includes magnesium or a magnesium-based alloy. The tie layer can have an outer surface comprising dendritic grains. The tie layer can have a rough outer surface defined by pores, projecting grain structures, and/or projecting particles. A method of producing a tie layer on a medical device includes applying magnesium or a magnesium-based alloy to the medical device and cooling the magnesium or the magnesium-based alloy to produce a rough outer surface. | 04-19-2012 |
| 20110319987 | MEDICAL IMPLANT - Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties. | 12-29-2011 |
| 20110319986 | IMPLANT AND METHOD FOR PRODUCING THE SAME - A method for producing an implant, particularly an intralumimal endoprosthesis, having a body, wherein the body comprises magnesium or a magnesium alloy. In order to control the degradation in a desired time window, such as between four weeks and six months, the following production method is carried out: a) preparing the implant body, b) applying a metallic coating onto at least a portion of the body surface, the primary constituent of the coating being at least one element of the group containing titanium and aluminum, c) plasmachemical treatment of the portion of the body surface provided with the coating in an aqueous solution in order to produce a layer created by plasmachemical treatment by applying a mixed voltage generating the plasma to the body of the implant, wherein the mixed voltage has sufficient energy to temporarily ionize both the metallic coating and a subjacent region of the implant body. The invention further relates to an implant that can be obtained by such a method. | 12-29-2011 |
| 20100057199 | SUBSTANCE WITH AN ANTIMICROBIAL EFFECT - The invention describes the use of an inorganic substance which forms hydrogen cations when in contact with an aqueous medium, which trigger an antimicrobial effect, the substance containing molybdenum and/or tungsten. | 03-04-2010 |
| 20100168843 | Coating For Implantable Devices And A Method Of Forming The Same - Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients. | 07-01-2010 |
| 20100087916 | Implant and Method for Producing a Degradation-Inhibiting Layer on the Surface of an Implant Body - A method for manufacturing a degradation-inhibiting first layer on the surface of an implant body, in particular an intraluminal endoprosthesis, whereby the body has at least one metallic material, which is at least largely biodegradable, comprising the following steps: preparing the body of the implant, and applying the first layer to at least a portion of the body surface, whereby the first layer contains magnesium stearate. An implant obtainable by such a method. | 04-08-2010 |
| 20080234812 | Stent spin coating method - A method is disclosed for spin coating a stent. The method comprises conducting the following acts at the same time: applying a coating substance to the stent; rotating the stent about a first axis of rotation; and rotating the stent about a second axis of rotation. | 09-25-2008 |
| 20080234811 | WETTABLE ePTFE MEDICAL DEVICES - Methods are provided for surface modifying a hydrophobic polymer substrate to increase wettability comprising the steps of pre-treating the hydrophobic polymer substrate with a radio frequency (RF)-generated first plasma and a RF-generated second plasma wherein the first plasma and the second plasma are applied sequentially, coating the hydrophobic polymer substrate with a hydrophilic coating; and polymerizing the hydrophilic coating on the hydrophobic polymer substrate by exposure to a RF-generated third plasma. | 09-25-2008 |
| 20130103139 | COATING OF ENDOPROSTHESES WITH A COATING CONSISTING OF A TIGHT MESH OF POLYMER FIBERS - The present invention relates to grid-like or net-like endoprosthesis having a continuous, respectively ongoing and interstices-spanning coating with a thread-tangle, wherein this continuous, respectively ongoing and interstices-spanning coating covers the struts as well as the interstices between the single endoprosthesis struts. | 04-25-2013 |
| 20130103138 | SURFACE MODIFICATION OF MEDICAL DEVICES TO ENHANCE ENDOTHELIAL ADHESION AND COVERAGE - Acceleration of the endothelialization process on implantable medical devices having at least one blood-contacting surface is achieved by a microscale pattern of sub-sections of EC-inductive coatings or EC-conductive coatings and nano/macro textured surfaces. The EC-inductive coating and EC-conductive coating can be applied either on the entire surface of the blood-contacting surface or selective placed on the blood-contacting surface, for example, in particular patterns. In this regard, the EC-conductive and EC-inductive coatings can be selectively placed relative to the textured surface to achieve a desired pattern of texture surface to coatings. | 04-25-2013 |
| 20100286766 | SURFACE MODIFICATION FOR COATING - A modified medical device substrate surface designed to improve adhesion of biomimetic surfactants to the medical device surface, thus reducing the risk of thrombosis is described. The surface modification is accomplished through either an application of a tie layer of a hydrophobic material on the substrate surface intermediate the biomimetic coating or through incorporation of a hydrophobic dopant in the polymeric substrate prior to extrusion or molding. Either method creates a hydrophobically modified surface that enhances the biomimetic surfactant bonding strength. | 11-11-2010 |
