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Sutureless closure

Subclass of:

606 - Surgery

606001000 - INSTRUMENTS

Patent class list (only not empty are listed)

Deeper subclasses:

Class / Patent application numberDescriptionNumber of patent applications / Date published
606215000 Material placed on opposed sides of incision or wound 159
606214000 Chemical bonding material applied to wound edges 79
Entries
DocumentTitleDate
20130072966Needle Apparatus for Closing Septal Defects and Methods for Using Such Apparatus - Apparatus and methods for closing a septal defect including a flap of tissue partially detached from a septum of a heart. A needle is advanced through a patient's vasculature within a delivery apparatus until the needle is disposed within a first chamber adjacent the septum. The needle is directed through the flap of tissue until the needle is disposed within a second chamber opposite the septum. A filament attached to an intermediate region of the needle is pulled, thereby causing the needle to pivot about the intermediate region such that the ends of the needle straddle the septal opening. A locking element is secured to the filament to secure the flap of tissue against the septum, and the filament is cut. Alternatively, the filament is biased to coil to engage the flap of tissue and secure the needle against the septum to close the opening.03-21-2013
20110178548MEDICAL SEALING DEVICE - The invention relates to a medical sealing device (07-21-2011
20110178547DEVICE AND METHOD FOR CLOSURE OF VESSEL ACCESS SITE - A device for closure of an opening formed in a body vessel includes a grasping member and a sheath movable thereover. The grasping member comprises a tubular body having a plurality of grasping fingers extending from a distal end of the tubular body. The fingers radially extend from the tubular body at a first angle, and are collapsible therefrom to a second angle. The fingers have a distal tip configured for grasping an outer wall of the body vessel surrounding the vessel opening when the fingers are at the first angle. The sheath is slidable over the tubular body and at least a portion of the grasping fingers for collapsing the fingers from the first angle to the second angle, thereby causing the collapsed fingers to at least substantially close the opening.07-21-2011
20120172926WOUND CLOSURE DEVICE INCLUDING PROGRIP STRAW - A wound closure device for positioning within a wound gap defined between at least two tissue segments has an effect of drawing the at least two tissue segments to a state of proximity that closes the wound gap. The wound closure device includes a tubular collapsible member having an expanded configuration and a collapsed configuration. The wound closure device further includes tissue engaging structure for attaching the tissue segments to the tubular collapsible member.07-05-2012
20100152772INTERVENTIONAL MEDICAL CLOSURE DEVICE - An interventional medical closure device is suitable for assisting closure of an opening through a blood vessel wall after completion of an interventional procedure within the internal lumen of the blood vessel. The device comprises a closure element, a grasping element for grasping the closure element, and a delivery element for delivering the closure element into the internal lumen of the blood vessel. The closure element comprises a suture, and an engagement foot at a distal end of the suture. The grasping element is inter-engageable with the closure element to grasp the closure element. The delivery element comprises a main body portion, and a distal nose. The distal nose defines a reception space for carrying the engagement foot of the closure element. The delivery element also comprises an engagement foot which is movable relative to the main body portion between a low-profile delivery configuration and a protruding engagement configuration.06-17-2010
20090192544METHOD OF IMPROVED VEIN CLOSURE - There are disclosed methods of vein closure. In an embodiment, a method includes elevating a leg of a patient during a vein closure procedure so as to effect substantial emptying of the vein. The method also includes applying radio-frequency energy to a vein within the leg of the patient to cause the vein closure. In another embodiment, a method includes elevating a leg of a patient during a vein closure procedure within a range of about 30 degrees to about 45 degrees from a horizontal position. The method also includes applying radio-frequency energy to a vein within the leg of the patient. In one embodiment, a method includes elevating a leg, and emptying of a segment of the vein prior to applying radio-frequency energy. In another embodiment, the method includes elevating a leg of a patient, and applying energy to a vein. Other embodiments are also disclosed.07-30-2009
20110196420Vacuum Patch For Rapid Wound Closure - A surgical patch system for closing a wound includes a first surgical patch, a second surgical patch, a cord operably associated with the first and second surgical patches, and a port operably associated with the second surgical patch. The first surgical patch is positionable adjacent internal tissue of an underlying tissue site of an open wound. The second surgical patch is positionable adjacent external tissue relative to the underlying tissue site of the open wound. The external tissue is adjacent the internal tissue. The cord is configured and dimensioned to interconnect the first and second surgical patches. The port is positioned to enable the application of negative pressure to the open wound.08-11-2011
20130211448MICROWAVE-POWERED REACTOR AND METHOD FOR IN SITU FORMING IMPLANTS - The present disclosure relates to an apparatus and process for forming medical devices from an injectable composition. The apparatus includes a supply assembly, a mixing assembly, and at least one source of microwave energy. The supply assembly is configured to maintain and selectively dispense a first precursor functionalized with a first reactive member and a second precursor functionalized with a second reactive member. The mixing assembly is configured to mix the first and second precursors within a mixing cavity defined therein. The microwave energy source is configured and adapted to irradiate the mixed first and second precursors within the mixing cavity.08-15-2013
20130211447Intracardial Implant for Delivery of Alarmins and Methods Thereof - The invention provides a cardiovascular occluder for treating a cardiovascular abnormality comprising a frame and an alarmin or an alarmin activator bound to the surface of the frame. The invention further provides methods of manufacturing the cardiovascular occluder and methods of treating cardiovascular abnormalities by delivering the cardiovascular occluder.08-15-2013
20100076485Methods and Systems for Medializing a Turbinate - Methods and systems for medializing a turbinate. Exemplary embodiments comprise methods and systems for repositioning a turbinate proximal to a septum. Certain embodiments comprise an implant and a flexible member coupled to the implant. Embodiments may also comprise an insertion device to install the implant in a desired location.03-25-2010
20100076484METHOD AND APPARATUS FOR REPAIRING VASCULAR ABNORMALITIES AND/OR OTHER BODY LUMEN ABNORMALITIES USING AN ENDOLUMINAL APPROACH AND A FLOWABLE FORMING MATERIAL - A method for repairing an abnormality in the wall of a body lumen, the method comprising: 03-25-2010
20100114157OCCLUSION DEVICE - An obturator for a bronchial tube or tubule of a human or animal lung comprises a blocking element (05-06-2010
20120245626METHODS OF USE OF A CLIP APPLIER - A method for closing an opening formed in a wall of a body lumen or body tissue can include positioning a splittable carrier tube adjacent to the opening, the carrier tube having a splittable distal end with an outer surface retaining a closure element in a substantially tubular configuration or having an asymmetrically-elongated tubular shape with a trapezoidal longitudinal cross-sectional profile. The method including splitting a distal end of the carrier tube with a splitter and deploying the closure element from the carrier flaps of the carrier tube and over the splitter to allow the closure element to engage at least a portion of the wall of the body lumen or the body tissue and substantially close the opening.09-27-2012
20130079811DEVICES AND METHODS FOR TREATING FISTULAE AND OTHER BODILY OPENINGS AND PASSAGEWAYS - Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.03-28-2013
20130079812PERCUTANEOUS NEPHROSTOMY PLUG DELIVERY DEVICE - A device for delivering a percutaneous nephrostomy plug is provided. The device comprises a tubular member configured for insertion into a biological body. The device further comprises a handle coupled to a proximal end of the tubular member. The handle comprises a pusher element, an actuation element, and a transmission. The pusher element is disposed within the tubular member, and is configured to deliver a plug through a distal end of the tubular member. The transmission is coupled to the tubular member and the actuation element, and the transmission is configured to cause a retraction of the tubular member relative to the pusher element in response to a depression of the actuation element. A first depression of the actuation element toward the tubular member urges a partial exposure of the plug. A second depression of the actuation element urges a further exposure of the plug.03-28-2013
20100036414SYSTEM AND METHOD FOR FACILITATING HEMOSTASIS OF BLOOD VESSEL PUNCTURES WITH ABSORBABLE SPONGE - A system for facilitating hemostasis of a puncture site in a blood vessel injects an absorbable sponge pledget in a hydrated state to a position at an exterior of the blood vessel puncture to facilitate hemostasis. The system includes a tract dilator for locating the puncture, an introducer, and a pusher. The introducer includes a staging chamber for receiving the absorbent sponge pledget and a delivery chamber having a diameter smaller than a diameter of the staging chamber into which a hydrated pledget passes. The pledget is hydrated and compressed within the introducer and then ejected with the pusher to the delivery site to facilitate hemostasis of the blood vessel puncture. The system delivers the absorbable sponge pledget over a guidewire to ensure the proper positioning of the pledget over the puncture. The implanted absorbable sponge once delivered expands rapidly to fill the target site and is absorbed by the body over time.02-11-2010
20100036413KERF CRANIAL CLOSURE METHODS AND DEVICE - The present disclosure is for a device for filling the gap (kerf) left in the repair of a craniotomy and the methods for using and manufacturing such a device. The kerf device may be a preparation of demineralized or partially demineralized bone or bone substitute formed into a malleable strip that can be pressed or molded into the opening in between the skull and bone flap in order to allow bone healing without a gap or indentation.02-11-2010
20130035719COMPOSITE PLUG FOR ARTERIOTOMY CLOSURE AND METHOD OF USE - A composite plug for arteriotomy closure, a method of manufacturing a composite plug for arteriotomy closure, and a method for the use of a composite plug for arteriotomy closure may include an elongate core member, and one or more layers disposed at least in part about the core member, where the composite plug has been partially compacted in a radial direction. The composite plug may include an outer member at least partially surrounding the core member.02-07-2013
20120209320TISSUE DRESSING KIT - A kit comprising a tissue dressing material for being applied in contact with the tissue of a patient and a detachment solvent for removing the tissue dressing material from the tissue. A method of treating a tissue of a patient, the method comprising the steps of: applying a water-soluble tissue dressing material in contact with the patient's tissue; and applying an acidic detachment solvent to the tissue dressing material for removing the tissue dressing material from the tissue. A method of treating a tissue of a patient, the method comprising the steps of: applying a liquid tissue dressing material in contact with the patient's tissue; and applying a detachment solvent to the tissue dressing material for removing the tissue dressing material from the tissue. A method of treating a tissue of a patient, the method comprising the steps of: applying a water-soluble tissue dressing material in contact with the patient's tissue; and allowing the water-soluble tissue dressing material to convert into a form in which it is insoluble in water at neutral pH. And a solid material comprising a polymer salt and glycerol, the glycerol content being at least 10% of the polymer salt content by weight, for use in a method of treating a human or animal tissue.08-16-2012
20130041404Heart Occlusion Devices - Devices for occluding an aperture in tissue or a vessel comprise a first flexible wire and a second flexible wire. Each of the first and second wires is comprised of a shape memory material. Each of the first and second wires is shaped into first and second geometric forms such that the first geometric form of the first wire and the first geometric form of the second wire form a first plate in a first plane, and the second geometric form of the first wire and the second geometric form of the second wire form a second plate in a second plane that is parallel to and remote from the first plane. The first and second plates are separated by a waist formed from two portions of the first wire and two portions of the second wire. Methods for occluding an aperture in tissue or a vessel using such devices are also provided.02-14-2013
20100042145METHOD FOR DELIVERING AN OCCLUSION PLUG - A device for delivering a plug (02-18-2010
20100042144Medical Device for Wound Closure and Method of Use - A medical device for wound closure, e.g., repairing perforations and tissue wall defects. The medical device has a barbed elongate body and an outer member. The medical device may further include a foam structure. The medical device may also include an inner member which may be a tissue scaffold. A method for closing tissue is also disclosed.02-18-2010
20100106185DEVICES, SYSTEMS, AND METHODS FOR ENDOSCOPIC GASTRIC MAGNETIC RESTRICTION - A device, system and method for providing tissue and organ restriction. A device is described with respect to restricting gastric capacity while avoiding nutritional deficiencies and other complications. Additionally, a system and method are described for using the device to restrict gastric capacity to perform a non surgical gastric procedure.04-29-2010
20100106184REDUCED-PRESSURE, ABDOMINAL TREATMENT SYSTEMS AND METHODS - A reduced-pressure abdominal treatment system has an open-cavity treatment device for providing reduced-pressure treatment proximate a patient's abdominal contents; a deep-tissue closure device for applying a closing force on a deep-tissue wound on a patient's fascia; a surface-wound closure subsystem for providing a closing force on a surface wound on the patient's epidermis; and a reduced-pressure supply subsystem operable to develop a reduced pressure. Methods are also included.04-29-2010
20130046339FENESTRATION SEALING DEVICE - A sealing device is configured to seal a fenestration within a stent graft. In one example, the sealing device has a biasing member that is used to retain a sealing member adjacent to the fenestration to prevent blood from escaping from the stent graft. The biasing member is configured to pull the sealing member against the fenestration to ensure a proper seal.02-21-2013
20100131007Self-Expanding Medical Occlusion Device - A self-expanding medical occlusion device treats a heart defect in a patient and is 05-27-2010
20130072967CLUTCH RELEASE MECHANISM FOR VASCULAR CLOSURE DEVICE - A method and apparatus for sealing a puncture or incision formed percutaneously in a tissue. The apparatus including an anchor, a sealing plug, a filament secured to the sealing plug and the anchor, a compaction member assembly, a spool, a driving plate, and a follower. The compaction member assembly is disposed adjacent the sealing plug and structured and arranged to apply an axially directed compressive force to automatically compact the sealing plug toward the anchor. The spool has a portion of the filament wound thereon. The driving plate is connected to the spool and arranged to contact and apply a force to a proximal end of the compaction member assembly upon rotation of the driving plate to advance the compaction member assembly. The follower is operable between the spool and driving plate to releasably connect the spool and driving plate to provide a clutch action.03-21-2013
20130072965Delivery Systems and Methods for PFO Closure Device with Two Anchors - A device closes septal openings, such as a patent foramen ovale (PFO). The device includes two anchors and a flexible connector. Tension applied to one or more strings attached to the device causes the device to collapse into a reduced profile form for withdrawal into a delivery catheter, thereby facilitating retrieval of the device after insertion into a septal opening.03-21-2013
20110015671Percutaneous Puncture Sealing System - A method of sealing percutaneous punctures in a patient's body that open into an internal body cavity using a sealing material such as a fibrin adhesive while preventing the sealing material from entering the body cavity. An apparatus for delivering the sealing material is also disclosed.01-20-2011
20110015670Percutaneous Puncture Sealing System - A method of sealing percutaneous punctures in a patient's body that open into an internal body cavity using a sealing material such as a fibrin adhesive while preventing the sealing material from entering the body cavity. An apparatus for delivering the sealing material is also disclosed.01-20-2011
20130060279CATHETER WITH SEALED HYDRATABLE HEMOSTATIC OCCLUSION ELEMENT - Apparatus for sealing a vascular wall penetration disposed at the end of the tissue tract comprises a shaft, an optional occlusion element, a hydratable hemostatic implant, and a protective sleeve. The apparatus is deployed through the tissue tract with the occlusion element optionally occluding the vascular wall penetration and inhibiting backbleeding therethrough. The hydratable hemostatic implant, which will typically be a biodegradable polymer such as collagen carrying an anti-proliferative agent or coagulation promoter, will then be deployed from the sealing apparatus by retracting the protective sleeve and left in place to enhance closure of the vascular wall penetration with minimum scarring. The hydratable implant will be protected from premature hydration and swelling by a soluble plug covering the implant's distal end prior to sleeve retraction.03-07-2013
20110066179MOBILE SUBSTRATE ATTACHMENT DEVICE - The present invention provides an attachment device′ having a substrate facing surface, wherein the substrate facing surface is provided with at least one flexible protrusion extending therefrom, said protrusion forming a flexible bridge between the substrate facing surface and a flexible substrate.03-17-2011
20120191129Emergency wound treatment device and method - An emergency medical device and method is provided for treatment of open wounds by enhancing clotting and arresting hemorrhaging, particularly in the area of the neck, abdomen, chest or groin. The devices includes an elongated delivery tube for insertion into a wound cavity and subsequent delivery of a space filling, sponge-like mass containing a polymerizable liquid sealant that polymerizes upon contact with body fluids after which the delivery tube is removed.07-26-2012
20090270911Vessel Sealing Device and Method of Using Same - A sealing device for sealing openings in blood vessels has a first and second sealing elements. The first element is preferably fixed attached to a rigid shaft. The second sealing element is slidingly movable relative to the rigid shaft in only one direction. The first and second sealing elements directly engage the walls of the blood vessel. One embodiment has a two portion shaft and one of the portions can be removed after the hole in the blood vessel is sealed.10-29-2009
20090062846CLOSURE MEDICAL DEVICE - A closure device for closing a puncture wound has a distal section that can be placed against the interior wall of a vessel and a proximal section that bunches in the tissue tract to close the wound.03-05-2009
20130066362Occluder - An occluder (03-14-2013
20130066363DEVICE FOR USE IN EYE SURGERY - A method of manufacturing an intraocular lens inside a capsular bag after the natural lens has been removed employs a sealing device comprising a plug part adapted to seal a rhexis in a capsular bag, thus preventing displacement through the rhexis of a lens-forming liquid material injected through the rhexis and adapted to replace the natural lens and form an intraocular lens implant. The plug part has a slightly larger area than the capsulorhexis and is made of a deformable polymer. The sealing device comprises an adjusting means connected to the plug part, the adjusting means having the function of positioning the plug part to a desired location.03-14-2013
20130066361APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - Apparatus for sealing a puncture through tissue to a blood vessel includes a cartridge including a proximal end, a distal end sized for insertion into a puncture, and a lumen extending therebetween. A bioabsorbable plug is disposed within the lumen adjacent the distal end, and an anchoring element is disposed within the lumen proximal to the plug. A pusher member is disposed within the lumen for deploying the plug and anchoring element out the distal end of the cartridge. The plug may be formed from lyophilized hydrogel and the anchoring element may be formed from air-dried hydrogel, the anchoring element hydrating slower than the plug when exposed to an aqueous environment. During use, the plug and anchoring element are delivered into the puncture, the plug is cinched against the vessel wall. Protrusions on the anchoring element engage tissue surrounding the puncture to prevent proximal movement of the plug.03-14-2013
20130066364VASCULAR HOLE CLOSURE DEVICE - A device for closing an aperture in a vessel wall comprising a covering member having a longitudinal axis and positionable inside the vessel against the internal opening of the aperture and having a dimension to prevent egress of fluid through the aperture and having a first opening. A first retainer is positionable external of the vessel. A flexible connecting member operatively connects the covering member and the first retainer, wherein the first opening of the covering member is configured to restrict movement of the connecting member.03-14-2013
20110022079MEDICAL DEVICE FOR MODIFICATION OF LEFT ATRIAL APPENDAGE AND RELATED SYSTEMS AND METHODS - A medical device, system and method for modifying a left atrial appendage (“LAA”). The medical device system includes a tether anchored within the LAA and one or more tissue growth members or occluders configured to be slid over the tether and lodged within the LAA. With this arrangement, a physician may close-off the LAA with a selective number of tissue growth members to meet the varying LAA sizes as determined from imaging information while conducting the procedure.01-27-2011
20120116446Specially Designed Magnesium-Aluminum Alloys and Medical Uses Thereof in a Hemodynamic Environment - The present invention relates generally to specially designed magnesium-aluminum (“Mg—Al”) alloys and medical uses thereof in a hemodynamic environment, and, more particularly to devices for sealing an opening formed through biological tissue (such as blood vessels) made from such specially designed magnesium-aluminum alloys.05-10-2012
20120116445Wound Closure Device Including Suction Step Sleeve - An access apparatus is adapted and configured to access an underlying body cavity. The access apparatus includes a sleeve including a plurality of tubules. The tubules are configured and adapted to suction fascia of opposing tissue tracts to facilitate wound closure. A method of using the access apparatus is also provided.05-10-2012
20090030450CLOSURE DEVICE - A medical closure device (01-29-2009
20130165968APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - An apparatus for sealing a puncture includes a cartridge, a pusher member, a sealant, and a tamping device on a proximal end of the cartridge. During use, the cartridge, sealant, and pusher member are advanced over a positioning member and into the puncture by advancing a cartridge hub carrying the tamping device. When further distal advancement of the cartridge is limited, the cartridge hub is further advanced, activating the tamping device, and causing the pusher member to advance relative to the sealant to compress the sealant within the puncture.06-27-2013
20130165969DEVICE FOR CONTROLLING A BLOOD FLOW PRODUCED IN A HEMORRHAGIC AREA - A device for controlling blood flow occurring in a haemorrhagic zone of a biological tissue, includes a flexible plate arranged to be placed opposite this zone, the flexible plate including: substantially leaktight peripheral supporting elements, for applying on the tissue so that the zone is surrounded; a back wall delimiting, with the supporting elements, opposite the zone, a hollow space; connecting elements connecting the hollow space, externally to the flexible plate, to an external aspiration source for creating a vacuum in the hollow space for aspirating and tightly applying the surface of the tissue against the peripheral supporting elements; and a hollow stud placed between the zone and the back wall and hollowed out in its centre on the side of the zone along an axis substantially perpendicular to the back wall, and arranged to be in contact with the zone when the vacuum is created in the space.06-27-2013
20130165965PRESSURE TRANSDUCER EQUIPPED CARDIAC PLUG - Disclosed herein is a pressure sensing left atrial occluding implantable medical device. The implantable medical device includes a cardiac plug and a micro electro-mechanical system (“MEMS”). The cardiac plug includes an expandable lobe and an expandable disc proximal the lobe. The expandable lobe is configured to expand into an anchoring arrangement within the left atrial appendage. The expandable lobe is configured to expand into an occluding arrangement with the left atrial appendage. The MEMS is coupled to the cardiac plug proximal of the disc. The MEMS is configured to sense surrounding fluid pressure.06-27-2013
20130165966Devices, Systems and Methods for Closure of Cardiac Openings - The invention generally relates to devices, systems, and methods for percutaneous closure of cardiac openings and obliteration of the cardiac cul-de-sacs. In one embodiment, a closure device includes a patch with an adhesive and/or a removable frame. The patch may be placed across a cardiac opening, such as a patent foramen ovale, or across a cardiac cul-de-sac, such as a left atrial appendage. In another embodiment, a closure device includes a balloon together with adhesives and/or substances for stimulating tissue growth coated on, or contained within, the balloon. The balloon may be inserted into a cardiac opening, such as the patent foramen ovale, or into a cardiac cul-de-sac, such as a left atrial appendage.06-27-2013
20130165967HEART OCCLUSION DEVICES - This disclosure is directed to an aperture occlusion device and a method for occluding an aperture, including a perimembranous ventricular septal defect. The aperture occlusion device includes a wire frame element. The wire frame forms geometric shapes that include an occluder region and a securing region. The occluder region and the securing region are separated by an attachment region including a waist. The occluder region and securing region can include membranous coverings. The device can be attached to a delivery hub. The wires forming the occluder region and securing region can have a shape-memory capability such that they can be collapsed and distorted in a sheath during delivery, but resume and maintain their intended shape after delivery.06-27-2013
20090012558FISTULA GRAFTS HAVING A DEFLECTABLE GRAFT BODY PORTION - This invention provides, in certain aspects, unique devices and methods for treating fistulae. In one embodiment, an inventive device includes an elongate graft body having a proximal end and a distal end. The graft body is configurable to a first condition and a second condition, the second condition including the distal end deflected laterally relative to its position in the first condition of the body. The device also includes a tether, which is connected to the graft body, and is configured to traverse proximally along the body. The tether is manipulable to convert the graft body from the first condition to the second condition. Such a device may also include one or more additional tethers connected to the graft body. For instance, a second tether can be configured to extend distally from the distal end of the graft body, and may be effective in pulling the graft body along a fistula tract.01-08-2009
20090012557DEVICE FOR CLOSING AN OPENING LOCATED IN A HEART SEPTUM - A device or a kit (01-08-2009
20100087852TEMPORARY SURGICAL CLOSURE FOR A BODY CAVITY - Described is an apparatus (04-08-2010
20100241161SURGICAL FASTENERS AND DEVICES FOR SURGICAL FASTENING - Disclosed is a surgical fastener having a first element, or crown, defining an axis of the fastener. Each prong of the fastener has a protuberance at one end that is received in a depression around an edge of the first element and rotatable in the depression and has a tip at a second end. In an undeployed configuration, each prong passes through a slot of the second element and the tip of each prong is at a first distance from the axis. In a deployed configuration, each prong passes through the prong's slot of the second element, and the tip of each prong is at a second distance from the axis that is greater than the first distance. Also disclosed is a system for surgical fastening including one or more surgical fasteners as disclosed herein and a surgical fastening device configured to deploy the fasteners.09-23-2010
20110093007SYSTEMS AND METHODS FOR TREATING SEPTAL DEFECTS - A system for treating a septal defect having an implantable treatment apparatus and devices for delivering the implantable treatment apparatus, devices for controlling delivery of the treatment apparatus and methods for treating a septal defect are provided. The implantable treatment apparatus is preferably implantable through a septal wall or portion thereof. The treatment system can include a flexible elongate body member, a delivery device configured to deliver the implantable apparatus, and a proximal control device for controlling delivery of the implantable apparatus, among others.04-21-2011
20110282381Therapeutic Cell Applicator Instrument with Modular Tips - A surgical device comprises a housing, a bioprocessing module, an end effector, and a pumping device. The bioprocessing module comprises media reservoirs, fluid conduits in communication with the reservoirs, and a port through which media is expelled. The end effector is configured for insertion into a lumen and delivering a tissue repair composition into that lumen. The end effector has at least one fluid conduit extending therethrough and at least one orifice in communication with the fluid conduit. The fluid conduit in the first end effector is in fluid communication with the port on the bioprocessing module. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the media reservoirs through the fluid conduit of the first end effector such that the tissue repair composition is expelled from the at least one orifice.11-17-2011
20110282382Fistula Repair Plug Having Multiple Layers - A surgical device is operable to coextrude a multilayered biocompatible tissue repair plug in situ within a lumen in a patient. The device comprises a handle, a shaft extending from the handle, a plurality of conduits extending through the shaft, a plurality of media chambers, and an actuator. At least one of the media chambers contains a suspension of at least one tissue fragment having at least one viable cell in a biocompatible carrier. The actuator is operable to cause media in each of the chambers to be urged through, and expelled from the orifice of, the conduit in communication therewith. The orifices are located at the distal end of the shaft such that media from the media chambers may be ejected into a lumen in a patient in order to form a multilayered biocompatible tissue repair plug in situ. The conduits and their orifices are all coaxially aligned.11-17-2011
20100262182Occlusion Instruments Comprising Bioresorbable Radiopaque Polymeric Materials, As Well As Related Products, Methods And Uses - Described are occlusion instruments (10-14-2010
20110301638SELF-LOCKING CLOSURE DEVICE FOR PERCUTANEOUSLY SEALING PUNCTURES - A closure device for sealing a percutaneous puncture in a wall of a body passageway of a living being. In an exemplary embodiment, the closure device includes an anchor configured to be brought into engagement with an interior of the body passageway, a plug including a proximal portion and a distal portion, a filament coupled to the anchor and the plug. The filament may include a first extending section. The closure device further includes a lock attached to the first extending section, wherein the collar is positioned between the lock and the anchor, wherein the lock frictionally engages the first extending section of the filament so that the lock is movable along the filament only in response to application of a force on the lock that overcomes the frictional engagement.12-08-2011
20110282383BIOADHESIVE APPLICATOR AND METHODS OF SEALING TISSUE PUNCTURES USING SAME - A closure device includes a delivery member, a sealing material applicator, and an expandable member. The delivery member is insertable through a tissue tract to a vessel puncture. The sealing material applicator is configured to supply a volume of sealing material to the delivery member and includes first and second multi-chamber devices and a valve assembly. Each chamber of the first and second multi-chamber devices holds a component of the sealing material, and operating the valve assembly permits mixing of at least some of the components prior to connecting the sealing material applicator to the delivery member. The expandable member is positionable within the vessel to temporarily seal closed the vessel puncture from within the vessel. The closure device is operable to deliver the sealing material from the sealing material applicator, through the delivery member, and to the tissue tract to seal closed the vessel puncture from outside the vessel.11-17-2011
20110301639One-Part Moisture-Curable Tissue Sealant - A tissue sealant is described that includes the reaction product of (a) a polyol having at least two groups capable of reacting with an alkoxy silane and (b) an alkoxy silane having the formula: (R12-08-2011
20110301641Systems And Methods For Treating Septal Defects - A system for treating a septal defect having an implantable treatment apparatus and devices for delivering the implantable treatment apparatus, devices for controlling delivery of the treatment apparatus and methods for treating a septal defect are provided. The implantable treatment apparatus is preferably implantable through a septal wall or portion thereof. The treatment system can include a flexible elongate body member, a delivery device configured to deliver the implantable apparatus, and a proximal control device for controlling delivery of the implantable apparatus, among others.12-08-2011
20110301640APPARATUS AND METHODS FOR SEALING A PUNCTURE IN TISSUE - An occlusion device for sealing a puncture through tissue includes a tubular wire member having a proximal end, a distal end sized for insertion into the puncture, a lumen extending between the proximal and distal ends, a port adjacent the proximal end communicating with the lumen, and a balloon on the distal end. A source of fluid is connectable to the wire member for delivering fluid via the port into the lumen for expanding the balloon. A piston is movable axially within the wire member to allow fluid to be delivered into the lumen, to isolate the lumen, and to deliver fluid within the lumen into the balloon to expand the balloon.12-08-2011
20110288581DEVICES AND METHODS USEFUL FOR SEALING BODILY OPENINGS - Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.11-24-2011
20110288580SYSTEM AND METHOD FOR VESSEL ACCESS CLOSURE - Embodiments are described for closing vascular access ports, such as arteriotomies, which involve placement and deployment of an expandable device configured to prevent blood flow across a subject arteriotomy while also keeping disturbance of intravascular flow to a minimum. Suitable prostheses may comprise one or more frames constructed from lengths of flexible materials, such as shape memory alloys or polymers. Such frames may be coupled to sheetlike or tube-like structures configured to spread loads, minimize thrombosis which may be related to intravascular flow, and maintain hemostasis.11-24-2011
20120191128VASCULAR WOUND CLOSING APPARATUS AND METHOD - Wound closure apparatus is provided including a body having an elongated, lowermost force-transmitting surface operable to be placed in a proximal, external, wound-closing position on a patient, together with a force-exerting assembly coupled with the body and operable to exert a downwardly directed force serving to generate wound-closing pressure against the patient's tissue. The force-transmitting surface is preferably three-dimensionally asymmetric so that forces of different magnitude are exerted at different locations along the length of the surface. The apparatus is especially designed for the closure of wounds attendant to endovascular interventions, e.g., a femoral artery puncture wound incident to percutaneous cardiac intervention (PCI), and is capable of quickly effecting wound closure with a time-to-ambulation (TTA) of approximately 60 minutes, and with a very low complication rate.07-26-2012
20090018574CLOSURE DEVICE - An interventional medical closure device comprises a first engagement element for engagement with an external surface of a vessel on a first side of an opening 01-15-2009
20110295316SYSTEM AND METHOD FOR VESSEL ACCESS CLOSURE - Embodiments are described for closing vascular access ports, such as arteriotomies, which involve placement and deployment of an expandable device configured to prevent blood flow across a subject arteriotomy while also keeping disturbance of intravascular flow to a minimum. Suitable prostheses may comprise one or more frames constructed from lengths of flexible materials, such as shape memory alloys or polymers. Such frames may be coupled to sheetlike or tube-like structures configured to spread loads, minimize thrombosis which may be related to intravascular flow, and maintain hemostasis.12-01-2011
20080255609LABELED VASCULAR PATCH - The present invention relates generally to a labeled vascular patch to be applied during surgical repair of blood vessels, which have become diseased by atherosclerosis or injured by trauma. More particularly, the present patch comprises a label, useful for locating the patch during post-operative recovery to assess the success of the surgery and/or during subsequent operations on the same portion of vasculature. The label can comprise any material useful for interacting with imaging energy including, but not limited to Radiation Energy (i.e. X-Rays) electromagnetic energy, sound energy, and light energy, and/or any other energy used for therapeutic imaging.10-16-2008
20100145383DRUG ELUTING VASCULAR CLOSURE DEVICES AND METHODS - Drug eluting vascular closure devices and methods for closing a blood vessel puncture site disposed at a distal end of a tissue tract are described. The devices and methods rely on a combination of the body's own natural mechanism to achieve hemostasis with bio-chemical agents to accelerate the hemostatic process. One method includes the steps of introducing a closure device through the tissue tract and deploying an expansible member at a distal end of the device within the blood vessel to occlude the puncture site. A bio-chemical sealing member disposed proximal the expansible member is then displaced so as to expose a bio-chemical region or release region of the device. At least one bio-chemical agent is thereafter released from the device and into the tissue tract to accelerate the occlusion process in the tract.06-10-2010
20120191131VASCULAR WOUND CLOSING APPARATUS AND METHOD - Wound closure apparatus is provided including a body having an elongated, lowermost force-transmitting surface operable to be placed in a proximal, external, wound-closing position on a patient, together with a force-exerting assembly coupled with the body and operable to exert a downwardly directed force serving to generate wound-closing pressure against the patient's tissue. The force-transmitting surface is preferably three-dimensionally asymmetric so that forces of different magnitude are exerted at different locations along the length of the surface. The apparatus is especially designed for the closure of wounds attendant to endovascular interventions, e.g., a femoral artery puncture wound incident to percutaneous cardiac intervention (PCI), and is capable of quickly effecting wound closure with a time-to-ambulation (TTA) of approximately 60 minutes, and with a very low complication rate.07-26-2012
20100069954CLOSURE DEVICES, RELATED DELIVERY METHODS AND RELATED METHODS OF USE - A device for sealing a patent foramen ovale (PFO) in the heart is provided. The device includes a left atrial anchor adapted to be placed in a left atrium of the heart, a right atrial anchor adapted to be placed in a right atrium of the heart, and an elongate member adapted to extend through the passageway and connect the left and right atrial anchors. The right atrial anchor preferably includes a plurality of arms and a cover attached to the arms. The left atrial anchor preferably also includes a plurality of arms and preferably does not include a cover. Preferably, the elongate member has a first end fixedly connected to the left atrial anchor and a portion, proximal to the first end, passing through the right atrial anchor. Preferably, the elongate member is flexible.03-18-2010
20120191130System and devices for the repair of a vertebral disc defect - A system for repairing a vertebral disc defect, such as hernia or bulge, a full or partial tear in the annulus, or a weakened annulus wall as a result of an excision procedure. The system introduces a treatment device arranged to repair the defect, and may prevent the leakage of fluid from the nucleus. The components of the device may be resorbable materials, and may induce the ingrowth of cellular material into the components. The system may feature a locating device to ensure proper placement of the treatment device.07-26-2012
20090125056SYSTEMS AND METHODS FOR PUNCTURE CLOSURE - Systems, apparatuses and methods are provided for use in closing punctures in vessel walls. An apparatus may have various combinations of an anchoring device, a positioning device and a heating element for closing a puncture within a vessel wall. An anchoring device may be a balloon, an expansible cage, a wire operated T-anchor, and/or a floating anchor. A positioning device may be a balloon, a sponge, and/or an expansible cage. A heating element may be flexible or rigid and preferably provides heat to target tissue through conduction and convection. A heating element may be flat-ended or dome-shaped. The heating element and anchoring device may be positioned a fixed distance apart to sandwich tissue between the heating element and the anchoring device. The heating element may operate in multiple stages. An initial stage may non-permanently adhere the heating element to the tissue and the subsequent stage may close the puncture.05-14-2009
20100114156CLOSURE DEVICE - A closure device for closing an opening in tissue is provided. The closure device according the present invention includes a delivery system for deploying a closure element, wherein the closure element is movable between a delivery configuration and a deployed configuration to close an opening in tissue. The closure device of the present invention may further include a charge of hemostatic material.05-06-2010
20090312790VASCULAR PUNCTURE SEAL ANCHOR NEST - The present invention provides a method and apparatus for sealing a subcutaneous tissue puncture. The method and apparatus increases the reliability of device function by creating a multi-level anchor nest in a carrier tube of a tissue puncture closure device. The multi-level nest allows an insertion sheath or other deployment member to slide between the carrier tube and the anchor to rotate and deploy the anchor within an artery or other lumen.12-17-2009
20090312789MAGNETIC DEVICES AND METHODS FOR SEPTAL OCCLUSION - A magnetic device and method are disclosed for providing a safer and more reliable technique for closing a hole or rupture in the septum of the heart. A device is disclosed with proximal and distal occluders that are connected to one another via a catheter and are inserted on either side of the hole or rupture. Also disclosed are two patches that are placed on either side of the hole or rupture with at least one of the patches being composed of magnetic material with the other being magnetic or metallic.12-17-2009
20110196422COMPOSITION, METHOD AND DEVICE FOR STABILIZING IMPLANTED HYDRAULIC DEVICES - Implanted hydraulic devices can be repaired and/or stabilized using a method wherein a fluid comprising a curable or solidifying component is introduced into said device and cured or solidified in said device. Embodiments of this method, as well as compositions and kits are disclosed.08-11-2011
20110196421METHODS AND DRESSINGS FOR SEALING INTERNAL INJURIES - Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings.08-11-2011
20100268271BRONCHIAL VALVE PLUG - The bronchial plug (10-21-2010
20100268270Magnetically Retained Incision Closure Devices And Methods Of Incision Closure Using Same - An incision closure device includes an elongated handle portion including a distal end, a first connector detachably affixed to the distal end of the handle portion, and a second connector adapted to be axially moveable along the handle portion, wherein the first and second connectors are magnetically attracted to one another.10-21-2010
20090149882APPARATUS, SYSTEM, AND METHOD FOR MIDDLE TURBINATE MEDIALIZER - An apparatus, system, and method are disclosed for medializing the middle turbinate following sinus surgery, thus preventing synacheiae, granulation tissue, and other complications of the prior art. The apparatus utilizes a fastening device configured to attach the middle turbinate to the nasal septum, a prong comprising a slender wand portion and a fastening module, and a handle configured to trigger deployment of the fastening means by activating the fastening module. The fastening device may be a staple, rivet, glue, or another similar device.06-11-2009
20080312684Apparatus and Method for Closing an Opening in a Blood Vessel Using a Permanent Implant - An apparatus and method for closing an arteriotomy site is disclosed. The apparatus includes inner and outer frames adapted to sandwich a blood vessel wall therebetween. The inner and outer frames may be manufactured from memory metals such that they can be compressed during the insertion into the tissue tract proximate the arteriotomy site, and then deployed into an expanded configuration larger than the dimensions of the arteriotomy opening itself. A universal joint connects the inner and outer frames to ensure proper pivoting therebetween. In addition, polymeric coverings can be provided on the inner and outer frames to ensure closure, while a collagen plug can also be provided between inner and outer frames to facilitate closure as well.12-18-2008
20110172702TISSUE PUNCTURE CLOSURE DEVICE WITH AUTOMATIC TAMPING - A method and apparatus for sealing a puncture or incision formed percutaneously in tissue separating two internal portions of the body of a living being with an anchor, a sealing plug and a filament connecting the anchor and sealing plug. The method and apparatus provide for automatic tamping and/or cinching of the sealing plug when the apparatus is withdrawn from the puncture site. The automatic tamping and/or cinching is facilitated by transducing a motive force generated by the withdrawal of the apparatus into a tamping and/or cinching force.07-14-2011
20100280545SYSTEM AND METHOD FOR BONDING LIVING TISSUE - A system for bonding living tissue including first tissue displacer functionality operative initially to cause displacement of edges of tissue into a mutual touching relationship along a seam prior to bonding thereof and second tissue displacer functionality operative following operation of the first tissue displacer functionality to cause displacement of the edges into a mutual non-touching relationship wherein the edges are in mutual propinquity.11-04-2010
20090306706OCCLUSION ELEMENT FOR OPENINGS IN THE HEART, IN PARTICULAR AN ASD OCCLUSION ELEMENT - An occlusion element (12-10-2009
20120109191ADHESIVE-BASED VARICOSE VEIN TREATMENT - An intraluminal member can be used to deliver an adhesive to a vein while causing the vein to spasm, thereby controlling adhesive migration and improving procedure efficacy.05-03-2012
20120109190DEVICES, SYSTEMS, AND METHODS FOR CLOSING AN APERTURE IN A BODILY TISSUE - Devices, systems, and methods for closing an aperture in a bodily tissue. In at least one exemplary embodiment of an aperture closure device of the present disclosure, the aperture closure device comprises an elongated body extending from a proximal end to a distal end, and a closure portion coupled to the elongated body, the closure portion configured to fit within an aperture of a bodily tissue and comprising a material capable of autoexpansion within said aperture.05-03-2012
20120109189METHODS AND SYSTEMS FOR ESTABLISHING HEMOSTASIS RELATIVE TO A PUNCTURE - Systems and methods for establishing hemostasis relative to a puncture in a lumen wall. A closure device includes a proximal portion and a distal portion. The proximal portion or distal portion rotates during deployment to either close a puncture or plug a puncture to establish hemostasis. A method includes positioning a closure device in a deployment device, positioning the closure device in the tissue tract, and actuating the deployment device to establish relative rotation between the distal portion and the proximal portion of the closure device.05-03-2012
20110087271Wound Closure Device - Biocompatible wound closure devices including an elongate body and a plug member are useful for wound repair.04-14-2011
20100305608AUTOLOGOUS WOUND SEALING APPARATUS - The apparatus is provided for sealing a vascular puncture tract by forming the autologous plug within the puncture tract, and extruding that plug into the puncture tract. The apparatus of the present invention forms an autologous blood plug by drawing blood into the apparatus from a vessel, mixing a blood congealing agent with the drawn blood, and ejecting a plug formed from the clotted blood within the puncture tract. Also provided are various closure elements to isolate the drawn blood from the vessel during mixture with the blood congealing agent, and to facilitate placement of the apparatus relative to the vessel.12-02-2010
20120239084Method and apparatus for solid organ tissue approximation - Surgical bolts are useful for solid visceral wound hemostasis. The devices utilize flexible, variable depth transfixing bolts that penetrate the viscera. These bolts bring the tissue into apposition and hold said tissue in apposition while the wound heals. These bolts, or soft tissue rivets, overcome the limitations of sutures that are currently used for the same purposes. The devices are flexible, bendable, and conformable in their wet or dry state. The bolts include pressure plates that are capable of exerting compressive pressure over broad areas of visceral wounds without causing tearing of the friable parenchyma. The bolts are placed and removed by open surgery or laparoscopic access. The bolts can be placed into tissue where both sides of the bolt are exposed, or they can be placed blindly into tissue where the bolt does not protrude out of the tissue at its distal end.09-20-2012
20120239083INTRACARDIAC CAGE AND METHOD OF DELIVERING SAME - A method of preventing ingress of material into the left atrium of a heart includes providing a delivery sheath, advancing the sheath distal end through an opening between the right atrium and the left atrium of the heart, providing an expandable cage, delivering the expandable cage to the left atrium, and expanding the expandable cage within the left atrium. The expandable cage includes a proximal end, a distal end, and a plurality of supports extending therebetween. The expandable cage also includes a first membrane provided at its proximal end and a second membrane provided at its distal end. The expandable cage has a collapsed configuration so that it can be received within the lumen of the delivery sheath, and an expanded configuration for deployment within the heart. When expanded, the first membrane is positioned at an opening between the left and right atria of the heart, and the second membrane is positioned at the ostium of the left atrial appendage. The first membrane substantially prevents passage of blood between the atria and the second membrane prevents passage of embolic material from the left atrial appendage into the left atrium of the heart.09-20-2012
20080269800ARTERIOTOMY CLOSURE SYSTEM WITH DUAL LUMENS SHEATH - An arteriotomy closure system includes a double barrel sheath having parallel dedicated lumens that merge at a distal juncture into a single common lumen. One of the dedicated lumens receives a dilator and the other a stapler. One of the dilator or stapler can be advanced from its dedicated lumen distally through the common lumen and beyond the distal end of the sheath while the other of the dilator or stapler is retracted into its dedicated lumen.10-30-2008
20100087853COMPOSITIONS AND METHODS FOR USE OF ALGINATE DURAL SEALANTS - The present invention comprises compositions and methods for use of an alginate dural sealant in conjunction with mammalian neurosurgical procedures, including but not limited to, the implantation of neuroprosthetic devices.04-08-2010
20110172703TISSUE SEALANT APPLICATOR SYSTEM - A tissue sealant applicator system includes a tissue sealant applicator having an elongate body forming a bore containing a tissue sealant component, a piston, and a spray adaptor in fluid communication with the bore and forming a gas flow path. The system also includes a control unit adapted to be connected to a gas source, and a first gas passageway connecting the gas flow path and the control unit. The applicator includes an actuating member cooperatively associated with the piston to eject the tissue sealant from the bore upon user actuation. The control unit is adapted to supply gas from the gas source to the first gas passageway essentially simultaneously with user actuation of the actuating member, and to permit the supply of gas to the spray adaptor from the gas source to continue to flow for a predetermined time delay after the user stops actuating the actuating member.07-14-2011
20100100123HEMOSTATIC IMPLANT - The present disclosure relates to hemostatic implants including a porous substrate having a first hydrogel precursor and a second hydrogel precursor applied thereto in a manner such that the first hydrogel precursor and second hydrogel precursor do not react with each other until the implant is placed at the site of implantation and exposed to the physiological fluids of a patient.04-22-2010
20110172704SOLDER FORMULATION AND USE IN TISSUE WELDING - Supersaturated gel formulations including a solution of chitosan, albumin, and a laser specific chromophore. Laser tissue welding methods using the gel formulations of the present invention are also described. In the methods, the gel formulation of the present invention is provided to a site for tissue repair and the laser specific chromophore within the gel is excited with a laser in order to fuse tissue by inducing protein denaturation. The gel formulations and laser tissue welding methods may be used, for example, to enable skull base repairs, aerodigestive endoscopic repairs, endoscopic endonasal surgical repairs, iatrogenic esophageal perforation repairs, laparoscopic abdominal surgical repairs, lung repairs, colon repairs, anastomosis of vessels, urologic/gynecologic endoscopic pelvic repairs, orofacial surgical repairs, dental replacement, skin closure, uterine closure and repairs after fibroidectomies and bladder surgery.07-14-2011
20090248064Insertion tool for a closure device - A medical apparatus (10-01-2009
20100125296BIOLOGICAL TISSUE CLOSURE DEVICE AND METHOD - Devices and methods for biological tissue closure are disclosed. Arteriotomy closure and hemostasis devices and methods are disclosed. A device that can provide a lateral tension across an opening in the tissue and apply energy to seal the tissue is disclosed. Methods for using the device are also disclosed.05-20-2010
20120143245CARRIER TUBE FOR VASCULAR CLOSURE DEVICE AND METHODS - A vascular closure device (06-07-2012
20090088794Connective Tissue Closure Device and Method - A device for closing wounds such as openings in blood vessels as well as a method of doing so are disclosed. The device employs a fabric wrapped around an expandable frame both of which are inserted into a blood vessel through an introducer sheath. Once inserted, the expandable frame expands thereby expanding the fabric therewith. The fabric is made from a bioabsorbable material and includes a plurality of microhooks extending therefrom. One suitable material is polylactic acid fiber. Upon retraction of the device, the microhooks engage the adventitia surrounding the blood vessel causing the fabric to remain in position sealing the opening even after the expandable member is retracted and removed as well as the introducer sheath As the fabric is made from a bioabsorbable material, the device can remain in place even after hemostasis is reached and eventually dissolve within the body.04-02-2009
20090088793APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - Apparatus and methods for sealing a puncture through tissue includes an introducer sheath sized for introduction into a puncture, cartridge sized for insertion into the introducer carrying a sealant, and a locking element for coupling the introducer sheath to the cartridge. When the cartridge is advanced into the introducer sheath, the locking element couples the introducer sheath to the cartridge such that subsequent retraction of the cartridge causes the introducer sheath to retract, thereby deploying the sealant from the cartridge within the puncture beyond the introducer sheath.04-02-2009
20090287244APPARATUS AND METHODS FOR ENGAGING TISSUE - An engaging element for engaging tissue is described. The engaging element may include a first member including at least one tissue engaging portion and a second member including at least one tissue engaging portion. The second member may be pivotally connected to the first member. The engaging element includes a locking mechanism operatively associated with the first and second member. The locking mechanism may be configured to inhibit the relative motion of the first and said second member. An engaging system for engaging tissue is described. The engaging system may include an engaging element for engaging tissue, a first member having at least one tissue engaging portion, and/or a second member including at least one tissue engaging portion. A method for engaging tissue is described. The method may include positioning an engaging element relative to an engaging element delivery device and/or to a portion of tissue.11-19-2009
20110172701INTERVERTEBRAL DISC ANNULUS REPAIR SYSTEM AND METHOD - A device for at least partially closing an aperture in an annulus fibrosus of an intervertebral disc of a patient comprises an implant delivery tool and an implant releasably coupled to the implant delivery tool. The implant delivery tool includes a substantially rigid outer tube having a sharpened distal tip, a body a body coupled to the proximal section of the outer tube, and a plunger assembly movable axially relative to the body and including a plunger member and a pusher tube coupled thereto and disposed within the outer tube. The implant includes first and second tissue anchors serially disposed within the distal section of the outer tube, and a flexible connecting element coupling the first and second tissue anchors including a knotless braided suture structure for adjusting the length of the flexible coupling element.07-14-2011
20080275500IMPLANTS FOR CREATING CONNECTIONS TO TISSUE PARTS, IN PARTICULAR TO SKELETAL PARTS, AS WELL AS DEVICE AND METHOD FOR IMPLANTATION THEREOF11-06-2008
20080275501MEDICAL DEVICE LOADING AND DELIVERY SYSTEMS AND METHODS - Described herein are systems and methods for inserting a hemostatic seal into a delivery device. One such system can include a loading tool and a delivery device configured to detachably mate with one another. The loading tool can house a hemostatic seal in its unfolded configuration and can fold the seal for delivery into the delivery device. The delivery device can then be advanced into the loading tool to insert the seal into the delivery device.11-06-2008
20120296372COLLAPSIBLE PLUG FOR TISSUE CLOSURE - A tissue closure device includes a collapsible plug and an actuator. The plug has a surface extending between a proximal face and an opposing distal face. A lumen extends through the plug between the proximal and distal faces along a longitudinal axis. The plug is collapsible between a non-collapsed state in which the lumen is open and a collapsed state in which the lumen is closed. The actuator is configured to move the plug between the non-collapsed state and the collapsed state by being pulled proximally, such as through the lumen.11-22-2012
20120296373CLOSURE DEVICES AND METHODS - A closure device for closing an opening in tissue is provided. The closure device includes an elongate member through which needles may be deployed. The closure device also includes a closure element having a foot portion and a needle guide portion. The foot portion and the needle guide portion are each movable between a delivery configuration and a deployed configuration. The foot portion includes cuffs removably mounted thereon and having sutures connected therebetween. The needle guide portion includes needle guide apertures that guide the needles to the cuffs. The needles securely engage the cuffs and draw the cuffs and suture through the lumen wall so that the opening in the lumen wall can be closed with the sutures.11-22-2012
20110208238APPLICATOR DELIVERY TIP EXTENSION - A delivery tip extension communicates an adhesive material from a fluid applicator tip to a site within a patient. The delivery tip extension has an elongated shaft with a proximal end portion, a central body portion, and a tapered distal end portion. The central body portion has a length between about 5 cm and about 45 cm. A lumen is defined within and extends along the elongated shaft from a proximal opening to a distal opening. The elongated shaft is relatively more rigid along the central body portion than along the distal end portion to facilitate driving the elongated shaft through the patient with reduced trauma to the patient by the distal end portion. The lumen is sized and shaped along the proximal end portion for securely receiving the fluid applicator tip inserted through the proximal opening such that a dispensing outlet on the fluid applicator tip is in fluid communication with the lumen. The delivery tip extension is sterilized or sterilizable.08-25-2011
20130218201METHODS AND SYSTEMS FOR TREATING COMPLEX FISTULAE - Described, in certain respects, are unique methods and systems for treating fistulae and other passageways and openings in the body. In some embodiments, treatment will be performed on fistulae that include a passage extending through a subcutaneous wall or wall-like structure. Illustratively, such a passage can extend through a subcutaneous tissue wall that includes, at a minimum, portions of an intestinal wall, and in this regard, such a wall can have a first side that is provided by the luminal side of the intestines and a second subcutaneous side that is provided, for example, by the abluminal side of the intestines and/or by other subcutaneous tissues adhered to this abluminal side. Some inventive products and methods involve sealing off the passage from both sides of the wall, for example, where a sealing element is placed on each side of the wall over an opening to the passage.08-22-2013
20080249561METHOD FOR PLICATING AND FASTENING GASTRIC TISSUE - A method for creating a plication within a hollow organ. The method uses an elongated member having an end effector attached to its distal end. The end effector has a substantially hollow housing, a fixed jaw extending distally from the housing, and a retractable jaw located within the housing. The method involves the step of inserting the end effector within an organ of a patient such that it is in contact with tissue. The method also involves applying vacuum through the elongated member so as to dispose tissue on the fixed jaw and at least partially within the housing. The method also involves creating a plication by sliding the retractable jaw so that it juxtaposes the fixed jaw.10-09-2008
20080249560METHOD FOR PLICATING AND FASTENING GASTRIC TISSUE - A method of implanting a device to maintain a plication within a hollow organ. The method uses an elongated member having an end effector at its distal end. The end effector has an outer cylinder having at least one opening, and an inner cylinder having at least one opening. The inner cylinder is at least partially disposed within the outer cylinder and the cylinders are rotatable with respect to each other. The end effector is detachable from the elongated member such that it can remain within the body cavity. The method involves the step of inserting the end effector within the organ of a patient such that it is in contact with tissue. The method also involves the step of applying vacuum through the elongated member so as to dispose tissue within the inner cylinder. The method also involves the step of creating a plication by rotating the cylinders with respect to each other. The method also involves the step of detaching the end effector from the elongated member.10-09-2008
20110270301SYSTEM AND METHOD FOR SEALING AN INCISIONAL WOUND - An apparatus, system, and method for treating an incisional wound having incisional walls is disclosed. The apparatus includes a conduit having a first end for receiving reduced pressure and a second end. The apparatus further includes a scaffold. The scaffold has opposing surfaces for positioning adjacent the incisional walls and is fluidly coupled to the second end of the conduit for receiving the reduced pressure. The scaffold is generally elongated in shape and has a thickness between the opposing surfaces that is sufficiently thin for positioning within the incisional wound. The apparatus further includes an internal manifold that has a primary flow channel extending generally longitudinally within the scaffold and between the opposing surfaces of the scaffold. The internal manifold is fluidly coupled to the second end of the conduit. The application of the reduced pressure through the scaffold and the internal manifold induces tissue apposition between the incisional walls.11-03-2011
20110270300HIGH SPEED SWELLING, PRESSURE EXERTING HEMOSTATIC DEVICE - The present invention provides devices and methods for treating wounds. The devices may include polymer particles capable of absorbing fluid such as blood. When devices of the invention are exposed to fluid, the fluid may enter the device and cause the polymer particles to swell. Devices of the invention may also apply pressure on wound cavities to stop or restrict the flow of fluid. In some embodiments, the devices may comprise components to facilitate absorption of fluid throughout the device, such as wicking elements and/or multiple compartments. One or more of the devices can be placed directly in the wound cavity, or in a containment structure and then into the wound cavity.11-03-2011
20120143244CLOSURE DEVICE - The present disclosure provides closure devices for closing an opening in a body vessel, systems for closing an opening in a body vessel, and methods of making a closure device for closing an opening in a body vessel. The closure device may include a plug, an intravascular anchor, a suture that couples the plug to the intravascular anchor and a cinching element that provides a compressive axial force to the plug, wherein the plug and cinching element are positioned over a length of the suture and the suture is secured to the intravascular anchor with a fastening portion embedded in the intravascular anchor.06-07-2012
20100004681WOUND CLOSURE METHODS - Methods and devices are provided for closing a puncture wound. In one exemplary embodiment, a puncture closure device is provided having an elongate tubular body that is disposable through a puncture in tissue and that includes proximal and distal portions. The proximal portion can be adapted to expand to form proximal wings upon rotation of the elongate tubular body, preferably in a first direction. The distal portion can be adapted to expand to form distal wings upon rotation of the elongate tubular body, preferably in a second, opposite direction. The proximal and distal portions can also be adapted to be moved toward one another as they expand upon rotation. As a result, the proximal and distal wings can engage tissue therebetween.01-07-2010
20100004680REINFORCED CLOSURE ANCHOR - A reinforced closure anchor includes a fabric layer having an adhesive side, an opposite non-adhesive side, and an outer edge. An anchor member layer having a reinforcing structure is disposed on the fabric layer. The anchor member is adhered to the fabric layer adhesive side. The anchor member is disposed within the outer edge of the fabric layer.01-07-2010
20100004679MEDICAL DEVICE - A medical device (01-07-2010
20080312683Apparatus and Method for Closing an Opening in a Blood Vessel Using Memory Metal and Collagen - An apparatus and method for closing an arteriotomy site are disclosed. The apparatus and method employ the use of a delivery sheath within which is provided an anchoring device formed of memory metal. The delivery sheath can be inserted through a tissue tract extending from an epidermal layer to the blood vessel wall, whereupon the anchoring device can be extended from the delivery sheath into the blood vessel itself The memory metal, once freed from the delivery sheath, obtains a non-linear or coiled configuration which can then be pulled back against the inner surface of the blood vessel to form a backstop. A biodegradable plug is then introduced into the tissue tract until it engages the backstop formed by the anchoring device thereby ensuring proper positioning of the biodegradable plug. The anchoring device can then be retracted through the biodegradable plug leaving the arteriotomy site substantially closed with hemostasis being formed therearound The various biodegradable plugs disclosed provide for improved retention of the biodegradable plug and proper positioning of the plug within the tissue tract.12-18-2008
20080269801SURGICAL STAPLER - A surgical stapler comprises a hollow shaft 10-30-2008
20090264920CATHETER-BASED SEPTAL OCCLUSION DEVICE AND ADHESIVE DELIVERY SYSTEM - A catheter-based occlusion device for sealing tissue openings comprises a guiding catheter, a catheter, and a septal occluder including a first disk-like member for deployment proximate to a first side of a tissue opening, a second disk-like member for deployment proximate a second side of a tissue opening, and a connector portion for connecting the first and second disk-like members, wherein the connector portion includes at least one aperture effective to dispense an adhesive. The occlusion device can then be detached.10-22-2009
20090264919Vascular Puncture Closure - An apparatus for placing a patch over a puncture wound in a blood vessel exteriorly of the vessel includes a device for delivering the patch in a folded form and then expanding the patch from its unfolded configuration while deploying the patch about the region of the vessel puncture.10-22-2009
20110009900METAL VASCULAR APERTURE CLOSURE DEVICE - A closure device to be inserted at least partially through a blood vessel wall aperture in a blood vessel wall, having at least two metal petals that can be inserted through the blood vessel wall aperture and into the lumen of the blood vessel. The petals are structured to prevent withdrawal through the blood vessel wall aperture when the length of the petal is generally aligned with the blood vessel wall. The metal petals have alignment features that tend to urge them into alignment relative to each other. The closure device includes a metal expansion member that is alterable from an unexpanded state to an expanded state. A bioabsorbable tensioning member interconnects the petals and the metal expansion member and is securable to the metal expansion member.01-13-2011
20080269802SURGICAL STAPLER - A surgical stapler comprises a hollow shaft 10-30-2008
20100145382TUBULAR PATENT FORAMEN OVALE (PFO) CLOSURE DEVICE WITH CATCH SYSTEM - The present invention provides a device for occluding an anatomical aperture, such as an atrial septal defect (ASD) or a patent foramen ovale (PFO). The occluder includes two sides connected by a central tube. The occluder is formed from a tube, which is cut to produce struts in each side. Upon the application of force, the struts deform into loops. The loops may be of various shapes, sizes, and configurations, and, in at least some embodiments, the loops have rounded peripheries. In some embodiments, at least one of the sides includes a tissue scaffold. The occluder further includes a catch system that maintains its deployed state in vivo. When the occluder is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture and the catch system is deployed so that the occluder exerts a compressive force on the septal tissue and closes the aperture.06-10-2010
20090069844Closure Device, Deployment Apparatus, and Method of Deploying a Closure Device - The present invention relates generally to medical devices and methods for sealing and closing passages formed through tissue. More specifically, the present invention relates to devices for sealing or closing an opening formed through biological tissue comprising a distal or outside margin or surface, and a proximal or inside margin or surface (i.e., a wall thickness), and to apparatuses and methods for delivering such devices, to control (or prevent or stop) bleeding (or the flow of other biological fluid or tissue). The openings comprise percutaneously formed punctures, incisions, or other openings formed through biological tissue, such as in blood vessels, organs, and the like.03-12-2009
20090082804Defect-Closure Device and Delivery Apparatus - Provided is a defect-closure device which has small area, and fixed position even in indwelling, and is surely retained in the predetermined position and has a simple configuration.03-26-2009
20090187215METHODS AND APPARATUS TO REDUCE A DIMENSION OF AN IMPLANTABLE DEVICE IN A SMALLER STATE - Devices and methods fabricating an implantable device are disclosed. A method of fabricating an implantable device is disclosed. The method includes positioning a planar base material. The planar base material has a first inner surface. The first inner surface has a first inner surface dimension. The planar base material has a first outer surface. The first outer surface has a first outer surface dimension. A portion of the first inner surface of the base material is removed to define an annular body movable from a first state towards a second state. The annular body includes a second inner surface having a second inner surface dimension and a second outer surface having a second outer surface dimension. The second inner surface dimension is smaller than the first inner surface dimension, the first outer surface dimension, and the second outer surface dimension.07-23-2009
20110224720DEVICES, SYSTEMS, AND METHODS FOR CLOSING A HOLE IN CARDIAC TISSUE - Devices, systems, and methods for closing a hole in cardiac tissue. In at least one embodiment of a device for occluding a tissue aperture of the present disclosure, the device comprises a body comprising a proximal end, a distal end, a sidewall, and at least one marker, the body tapered towards the distal end and defining a body aperture therethrough capable of receiving an elongated member. In at least one embodiment, the body further comprises a diaphragm positioned at or near one or more of the proximal end of the body and/or the distal end of the body. In another embodiment, the diaphragm comprises a plurality of sheaths, wherein the plurality of sheaths sealably obstruct the body aperture.09-15-2011
20090177225Vascular closure device having sensor - A vascular closure device including a first retainer positioned on an internal surface of a vessel wall defining a passage through a vessel. A second retainer is coupled to the first retainer and positioned on an outer surface of the vessel wall to seal an opening defined through the vessel wall. A sensor is coupled to the first retainer and configured to sense a physical, chemical, and/or physiological parameter within the passage.07-09-2009
20090187214PERCUTANEOUS CATHETER DIRECTED INTRAVASCULAR OCCLUSION DEVICE - Embodiments of the present invention provide medical devices and methods for occluding a target site are provided. For example, the medical device may include a tubular member having proximal and distal ends and at least one plane of occlusion. The at least one plane of occlusion may be configured to substantially occlude the patent ductus arteriosus in less than about 1 minute. In addition or alternatively, the tubular member may consist of a single layer of material and be configured to be constrained within a catheter having an outer diameter of less than about 4 French for percutaneous delivery to the patent ductus arteriosus.07-23-2009
20090187213Vascular hole closure device - A device for closing an aperture in a vessel wall comprising a covering member having a longitudinal axis and positionable inside the vessel against the internal opening of the aperture and having a dimension to prevent egress of fluid through the aperture. Two curved legs are provided having portions positionable external of the vessel and having first and second loop portions positioned external to the internal region of the vessel wall to contact tissue.07-23-2009
20090143815Apparatus and Method for Sealing a Vessel Puncture Opening - A device for sealing a puncture opening in a wall of a blood vessel may include a base frame including a first bi-stable material having a first stable state corresponding to a delivery configuration of the base frame, in which the base frame is retracted to have a relatively smaller overall profile, and a second stable state corresponding to a deployed configuration of the base frame, in which the base frame is extended to have a relatively larger overall profile. The base frame is sized to engage an interior surface of the blood vessel wall when in the deployed configuration. A sealing section is coupled to the base frame and includes a second bi-stable material having a first stable state corresponding to an initial configuration of the sealing section, in which the sealing section permits fluid flow, and a second stable state corresponding to a barrier configuration of the sealing section, in which the sealing section prevents fluid flow. The sealing section in the barrier configuration is sized to block fluid flow through the puncture opening when the base frame is in the deployed configuration.06-04-2009
20080319475Methods, Devices, and Apparatus for Managing Access Through Tissue - Devices and methods for managing access through tissue is disclosed. The device includes a body. The body is movable from a pre-deployed configuration towards a deployed configuration. The device includes a plurality of tissue engaging portions that extend from the body. At least a portion of the tissue engaging portions are obtuse. At least two of the tissue engaging portions are separated by a first distance in the deployed configuration and a second distance in the pre-deployed configuration. The first distance is smaller than the second distance. The method includes deploying a closure element to tissue adjacent a tissue opening to substantially close the opening following a first procedure. The method also includes selectively opening the opening in the tissue by advancing a distal end of a medical device through the deployed closure element as a part of or before a second procedure.12-25-2008
20080319476Hemostatic mineral compositions and uses thereof - The invention generally relates to compositions and methods for promoting hemostasis and sealing a wound by producing an adhesive cast. In particular, the invention provides compositions comprising clay minerals with specified particle sizes, which, when applied to a bleeding area, allow for a desired result in at least one of the following activities: stopping blood flow from a wound, forming a cohesive mass, sealing a wound, promoting coagulant activity, sorbing a body fluid, and adhering to tissue. For example, the desired result can be sealing the wound using an adhesive cast made of clay minerals mixed with blood or other wound fluids.12-25-2008
20090326578INTERLOCKING TISSUE ANCHOR APPARATUS AND METHODS - Interlocking tissue anchor apparatus and methods are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. Anchor assemblies can be delivered via the tissue manipulation assembly into or through the tissue. The anchors can incorporate various temporary interlocking features or spacing elements between one another to ensure that an anchor is not prematurely ejected from the needle assembly. This allows the anchor assembly to be advanced distally as well as withdrawn proximally within a deployment sheath while avoiding inadvertently ejecting an anchor.12-31-2009
20110224721Universal Introducer - A device for introducing a catheter into a vessel through a puncture in a vessel and for sealing the puncture. The device includes an elongated body having a proximal end and a distal end sized to be positioned within a tissue site which includes the puncture. The elongated body includes a utility lumen sized to allow a catheter to be delivered through the utility lumen. The utility lumen is positioned within the elongated body so positioning the elongated body within the tissue site allows a catheter delivered through the utility lumen to enter the vessel. The elongated body also includes a closure lumen having an entrance port. A closure composition can be delivered through the entrance port into the closure lumen. The closure lumen also includes an exit port adjacent the distal end of the elongated body. The closure composition delivered into the closure lumen can be delivered through the exit port to the tissue site adjacent the puncture.09-15-2011
20110224719BIOABSORBABLE PLUG - In one example implementation, a device for closing an opening in tissue includes a proximal end and a distal end. The device further includes a port that extends from the proximal end of the device towards the distal end of the device. In addition to extending from the proximal end of the device towards the distal end of the device, the port includes a restriction zone and a storage region. The device further includes a blocking element that is configured to move between a neutral position, located in the storage region of the port, and a blocking position, located in the restriction zone of the port. When the blocking element is in the blocking position, the blocking element cooperates with the restriction zone in the port to assist in blocking fluid flow through the port.09-15-2011
20110224722Occlusion Device And Surgical Instrument And Method For Its Implantation/Explantation - An occlusion device includes a braiding of thin wires or threads tapering to the diameter of a catheter used for an intravascular implantation/explantation procedure and having a proximal retention area, a distal retention area at which ends of the wires or threads converge into a holder, and a cylindrical crosspiece interposed between the proximal retention area and the distal retention area, whereby the two retention areas are positioned on two sides of a shunt to be occluded in a septum following implantation while the crosspiece transverses the shunt. The holder exhibits a head section at its free end having an eyelet as a cross-hole which can be gripped and held in form-fit fashion by an implantation/explantation instrument. A surgical instrument having such a holder includes gripper tongs with gripping jaws which open and close by a push/pull system, and which force-fit grips the head section of the holder.09-15-2011
20090024161METHODS AND DEVICES FOR UTILIZING THERMAL ENERGY TO BOND, STAKE AND/OR REMOVE IMPLANTS - A fastener including material meltable at a temperature not likely to produce substantial tissue necrosis of neighboring body tissue, or “bondable material”, is caused to soften or melt by the application of vibratory energy, advantageously including ultrasonic vibratory energy. Vibratory energy is applied using a horn applied to the fastener, and tuned to generate vibratory motion proximate the horn, or at a point distal to the horn, for example at a point along the fastener body, or at the end of the fastener. Melted or softened material of the fastener bonds to a contacting surface, which may be body tissue or another implant. The contacting surface may also include bondable material, softenable or meltable through vibratory energy derived from contact with the fastener. To improve a bond, particularly where dissimilar materials are to be bonded, one or more contacting surfaces is provided with a roughened or porous surface, or a surface including one or more cavities or projections into or onto which softened or melted bondable material may form, bonding once the bondable material has cooled.01-22-2009
20090062845BARREL OCCLUSION DEVICE - An occlusion device for occluding a body vessel including a first hub having a tubular wall defining a lumen having a longitudinal axis and a second hub disposed distally along the longitudinal axis. A plurality of arcuate members extend between the first hub and the second hub. The arcuate members extend radially away from the longitudinal axis in an open configuration and extend substantially along the longitudinal axis in a closed configuration. A biocompatible material is disposed within a volume defined by the arcuate members to form an occlusive barrier when deployed within the body vessel.03-05-2009
20090054926EXTRA-VASCULAR SEALING DEVICE AND METHOD - Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. In one embodiment, the closure device includes a vessel locating member, an anchor and a sealing material. The closure device may be configured to deploy the anchor and the sealing material outside of a hole in a blood vessel to close the hole. The vessel locating member may be used to locate the blood vessel to ensure that the anchor and/or the sealing material are properly placed adjacent to the hole. The closure device may also include a tamper member configured to push or tamp the sealing material against the anchor. The closure device may also include a suture that is used to hold the sealing material and the anchor together adjacent to the hole in the blood vessel.02-26-2009
20090054927FISTULA PLUGS AND APPARATUSES AND METHODS FOR FISTULA PLUG DELIVERY - Described are methods and apparatuses for delivering fistula plugs into fistulae having at least a primary fistula opening, a secondary fistula opening, and a fistula tract extending therebetween. Illustratively, some inventive methods involve delivering a fistula plug into a fistula tract through a primary fistula opening and toward a secondary fistula opening, while others involve delivering a fistula plug into a fistula tract through a secondary fistula opening and toward a primary fistula opening. In certain aspects, a fistula plug is pushed and/or pulled through a fistula tract along a guidewire or other plug-guiding device, potentially protected by a protective delivery device such as a sheath, capsule or other suitable delivery vehicle.02-26-2009
20090082803BRAIDED VASCULAR DEVICES HAVING NO END CLAMPS - In some embodiments, a medical device may include one or more of the following features: (a) a metal fabric formed of braided metal strands, (b) the medical device having a collapsed configuration for delivery through a channel in a patient's body and having a generally dumbbell-shaped expanded configuration with two expanded diameter portions separated by a reduced diameter portion formed between opposed ends of the device and unsecured metal strand ends at the opposed ends, and (d) a thrombogenic agent located on the metal fabric.03-26-2009
20090082802Mechanism and Method for Closing an Arteriotomy - Devices and methods for closing an arteriotomy by gripping surfaces of tissue disposed about the arteriotomy, without piercing the tissue, and drawing the gripped tissue together to approximate the edges of the arteriotomy, and, while holding the tissue, applying a more permanent closure to the tissue.03-26-2009
20090069843FISTULA PLUGS INCLUDING A HYDRATION RESISTANT COMPONENT - Described, in certain aspects, are devices and methods for treating fistulae. In one embodiment, a fistula plug includes a hydratable component and hydration resistant component incorporated on or in the hydratable component. Illustratively, an inventive plug can include a first component and a second component, wherein the first component is hydratable, and the second component is less receptive to hydration than the first component (or is essentially non-hydratable). Either of these components may be formed with one or more of a variety of biocompatible materials including some that are naturally derived and some that are non-naturally derived. In one embodiment, the first component and the second component, while dissimilar in their receptivity to hydration, are both comprised of a remodelable, angiogenic material, for example, a remodelable extracellular matrix material such as submucosa.03-12-2009
20120078295OCCLUDER - The invention relates to an occluder for closing a passage in a circulatory system comprising an expandable fixation unit for fixing the occluder on the passage, wherein the occluder can be transferred in the passage from a compact appearance into an expanded appearance. The occluder has a distal and a proximal axial part, in which the fixation unit is pivotally held. According to the invention, the fixation unit comprises distal fixation arms and proximal fixation arms, wherein the distal fixation arms are pivotally held in the distal axial part and the proximal fixation arms are pivotally held in the proximal axial part. The distal and the proximal fixation arms have free ends, which are interconnected by means of connecting members that can be moved relative to the fixation arms, wherein in each case a distal fixation arm is connected to a proximal fixation arm located diagonally opposed thereto. Said occluder is suited in particular for closing a ventricular septal defect (VSD).03-29-2012
20120078293APPLICATORS FOR PATCHES AND ADHESIVES - Apparatus is provided for use with a tubular structure (03-29-2012
20090204145SPIRAL OCCLUDING DEVICE WITH AN OCCLUSION SAIL - An occluding device designed for occlusion of fluid flow through a body cavity is disclosed. The device comprises a coil having a proximal portion and a distal portion extending longitudinally from the proximal portion. The coil has an initial tension along the distal and proximal portions and is configured have a general helical shape in an expanded state. The device further comprises a first set of fibers attached to the coil and extending therefrom for occlusion of the body cavity. The device further comprises a second set of fibers attached to the coil at a plurality of areas longitudinally along the coil, defining an occlusion sail disposed longitudinally along the coil at the plurality of areas therealong. The second set of fibers is configured have the general helical shape when the coil is in the expanded state for enhanced occlusion of the body cavity.08-13-2009
20090210000PERCUTANEOUS PEDICLE PLUG AND METHOD OF USE - A percutaneous pedicle plug for use insertion into a screw opening in a vertebral body is described. The percutaneous pedicle plug includes a first end, a tapered second or tail end 08-20-2009
20090210001DEVICE FOR IMPLANTING AN OCCLUSION DEVICE IN THE HEART08-20-2009
20090209999Device and Method for Closure of Atrial Septal Defects - The present invention is directed towards implantable, inflatable, bioabsorbable medical prostheses. In particular, the present invention relates to an implantable, inflatable, bioabsorbable method and device for occluding septal defects such as an atrial septal defect. A double button shaped device is contained in a catheter to allow for easy positioning and re-positioning of the apparatus to ensure proper placement and deployment. The device is charged with a filling solution so that it temporarily stabilizes the defect for a period of time typically varying from weeks to a year while it provides a structure to support natural tissue growth. The device is eventually replaced by natural tissue as it degrades and is absorbed or eliminated from the body by natural processes.08-20-2009
20100274280APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - Apparatus and methods for sealing a puncture through tissue or otherwise treating a body lumen of a patient. The carrier includes at least one, but not all, of the adherent layer components required to form a tacky or sticky adherent layer on the carrier. The remaining adherent layer precursor(s) are delivered to the carrier in situ to form a sticky and/or tacky adherent layer on the carrier that enhances the attachment and retention of the carrier to tissue surrounding a target treatment location in which the carrier is delivered. The carrier may include hydrogel and/or other porous material, e.g., for releasing one or more agents carried by the carrier at the treatment location.10-28-2010
20100274279Device, System and Method for Mixing - The present invention includes various compositions, devices, systems and methods for mixing at least two separate streams of components. In one aspect of the invention, a device is provided for mixing at least two separate streams of components which, when mixed, form a combined fluid stream. The device comprises a first passageway adapted to communicate with one of the at least two separate streams, and a second passageway adapted to communicate with another of the at least two separate streams. The device further comprises a mixer communicating with each of the first and second passageways comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough. The mixer has physical characteristics which include a selected one or more of mean flow pore size, thickness and porosity is positioned upstream of the dispensing end of the third passageway to mix the component streams of the combined fluid stream.10-28-2010
20090275978SELF-TENSIONING VASCULAR OCCLUSION DEVICE AND METHOD FOR ITS USE - The present invention advantageously provides self-tensioning occlusion devices, systems, and methods for percutaneous access and closure of vascular puncture sites. One device comprises a catheter body having a proximal end and a distal end, an occlusion member, and a tensioning member. The occlusion member, such an expansible member, is disposed on a distal end of the body. The tensioning member, such as a spring or coil, is slidably disposed over the body and proximal the expansion member. Generally, during application, the tensioning member will be positionable against subcutaneous tissue so as to lodge and anchor the expansible member against the puncture site. In particular, the expansible member allows for sealing of the puncture site while the tensioning member applies and maintains tension to the expansible occluder so that it is seated against the puncture site at a vascular surface.11-05-2009
20100160959SURGICAL FASTENING SYSTEM AND METHOD FOR USING THE SAME - A surgical fastening system for attaching one piece of tissue to another piece of tissue. The system comprises a surgical fastener, an installation tool for deploying the surgical fastener in tissue, and a method for using the same.06-24-2010
20100191279DEVICES, SYSTEMS, AND METHODS FOR PERCUTANEOUS TRANS-SEPTAL LEFT ATRIAL APPENDAGE OCCLUSION - A device, system and method for occlusion of the left atrial appendage. A device is described with respect to non-surgically occluding the left atrial appendage with minimal invasiveness. Additionally, a system and method are described for using the device to perform the left atrial appendage occlusion procedure.07-29-2010
20080215087BODILY LUMEN CLOSURE APPARATUS AND METHOD - An absorbable and expandable closure member used to occlude or exclude a body lumen or cavity, such as a blood vessel, fallopian tube, duct, aneurysmal sac, etc., comprising a closure member comprising one of more sheets of a biomaterial that are rolled, stacked, or folded to form a multilayer construct of a generally cylindrical configuration for deployment through a delivery system, either as a singularly or part of a multiplicity of closure members. The biomaterial is derived from a source material, such as small intestinal submucosa or another remodelable material (e.g., an extracellular matrix) having properties for stimulating ingrowth of adjacent tissue into the biomaterial deployed within the bodily lumen. The closure member is deployed to the bodily lumen from a delivery sheath, cartridge, and/or over a inner guiding member, such as a wire guide or catheter.09-04-2008
20120197292PATENT FORAMEN OVALE CLOSURE METHOD - The present invention relates to devices for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart, and related methods of using such closure devices for closing the passageway. The method includes introducing a mechanical closure device into an atrium of the heart and transeptally deploying the closure device across the interatrial septum to provide proximation of the septum secundum and septum primum.08-02-2012
20100228285MEDICAL DEVICE FOR MODIFICATION OF LEFT ATRIAL APPENDAGE AND RELATED SYSTEMS AND METHODS - Medical devices, systems and methods for modifying a left atrial appendage (“LAA”). In one embodiment, a medical device system includes a jailing member or structure positioned over the ostium of an LAA and at least one tissue growth member positioned within the LAA and retained within the LAA by the jailing member. In another embodiment, a medical device includes an atrial stent coupled with a patch that is configured to cover the ostium of an LAA. The patch may have a tissue growth member associated therewith. In another embodiment, the patch may include an open-cell frame which may be used as a jailing member or structure.09-09-2010
20100160958Closure Device - Devices and methods are disclosed herein for a closure device. A closure device includes a body movable from a pre-deployed configuration towards a deployed configuration, a plurality of tissue-engaging portions extending from the body. At least two of the tissue-engaging portions are separated by a first distance in the deployed configuration and a second distance in the pre-deployed configuration in which the first distance is smaller than the second distance. The closure device also includes a plurality of device-capture features secured to the body. The device-capture features are configured to move the tissue-engaging portions to a separation greater than the first distance.06-24-2010
20100241162VOLUMETRIC GRAFTS FOR TREATMENT OF FISTULAE AND RELATED METHODS AND SYSTEMS - Described are devices, methods, and systems useful in the treatment of fistulae, and in certain embodiments those having openings extending into the alimentary canal, such as anorectal fistulae. Illustratively, an anorectal fistula can be treated by placing a volumetric construct within the primary opening of the fistula. In certain embodiments, the volumetric construct can include a rolled remodelable material processed to form a substantially unitary body. Advantageous such remodelable materials can include collagenous extracellular matrix materials, such as small intestine submucosa.09-23-2010
20100217309PLUG FOR ARTERIOTOMY CLOSURE AND METHOD OF USE - The disclosure provides a modified arteriotomy closure plug, said modification selected from the group consisting of a slit, a notch, a groove, and combinations thereof and a method of manufacturing the arteriotomy closure plug.08-26-2010
20100217308LOCKING ELEMENT FOR VASCULAR CLOSURE DEVICE - In one illustrative example, a device for sealing an opening in a vessel wall and/or tissue tract may include an anchor, a filament, a plug, and a knot. The anchor may be configured to be disposed adjacent to an interior surface of the vessel wall adjacent the opening in the vessel wall. The filament may have a distal end coupled to the anchor and may be configured to extend proximally through the vessel opening and/or tissue tract. The plug may be disposed about at least a portion of the filament member. The knot may be disposed about the filament proximal of the plug and may be configured to move over the filament and secure the plug relative to the anchor. The knot may be independent of the filament member.08-26-2010
20100217310MODIFIED PLUG FOR ARTERIOTOMY CLOSURE - The disclosure provides a modified arteriotomy closure plug, the modification consisting of subjecting a bioabsorbable foam closure plug to radial compression and/or axial bending until at least some struts of the foam have been torn or elongated within at least one axially disposed region.08-26-2010
20100217312COMPOSITE PLUG FOR ARTERIOTOMY CLOSURE AND METHOD OF USE - The disclosure provides a composite arteriotomy closure plug, a method of manufacturing the composite arteriotomy closure plug, and a method for the use thereof.08-26-2010
20100217313SYSTEMS FOR VENOUS OCCLUSION FOR THE TREATMENT OF VENOUS INSUFFICIENCY - Methods, devices and systems are described for treating venous insufficiency in which the vein is compressed at least partially along a treatment zone. A system can be provided including an injection device, such as a glue gun, that is operably connected to a delivery catheter that can be advanced across a treatment zone in the vein. The delivery catheter can be used to deliver one, two, or more boluses of media (e.g., cyanoacrylate) to occlude the vein along different spaced-apart sections of the treatment zone. External compression can also be applied to the vein by a compression element, such as a hand or multifunctional ultrasound transducer, to occlude portions of the vein along the treatment zone prior to or during the introduction of the boluses of media.08-26-2010
20100228286Clip Apparatus For Closing Septal Defects And Methods Of Use - A device for closing a septal defect, such as a patent foramen ovale, includes a clip formed from a superelastic material that is inserted into a septum wall of a heart. The clip is advanced through a patient's vasculature, e.g., within a delivery apparatus, until the clip is disposed within a first chamber adjacent the septal defect. Tines of the clip are directed through a flap of tissue of the septal defect until the tines of the clip are disposed within a second opposing chamber. The clip then transforms into its relaxed state, wherein the tines of the clip engage with a surface of the second chamber, thereby substantially closing the septal opening.09-09-2010
20100217311TISSUE PUNCTURE CLOSURE DEVICE - The present disclosure relates generally to methods and devices for closing and/or sealing an opening in a vessel wall and/or an adjacent tissue tract. In one illustrative embodiment, a device is provided for delivering and deploying an anchor, plug, filament, and/or locking element adjacent to the opening in the vessel wall and/or tissue tract.08-26-2010
20100241160METHOD AND KIT FOR CYST ASPIRATION AND TREATMENT - A method and kit for aspirating and treating a cyst is provided. In an embodiment, the method comprises aspirating fluid from the cyst through a first lumen, while venting the cyst using a second lumen, so as to stabilize pressure variations within the cyst. The aspirated cyst is then injected with a tissue sealant using the second lumen, while continuing to vent the cyst using the first lumen. To enhance visualization of the tissue sealant during imaging, the tissue sealant may be augmented so as to increase its radio-opacity.09-23-2010
20100234880Systems and Methods for Treating Septal Defects - A system for treating a septal defect having an implantable treatment apparatus and devices for delivering the implantable treatment apparatus and methods for treating a septal defect are provided. The implantable treatment apparatus is preferably implantable through a septal wall or portion thereof. The treatment system can include a flexible elongate body member, a delivery device configured to deliver the implantable apparatus, a stabilization device configured to stabilize the body member and a positioning device configured to position the delivery device in a desired location.09-16-2010
20110112573METHODS AND DEVICES FOR USE WITH SEALANTS - A biocompatible medical sealant for use in a biological system, the sealant comprising a solution of a cross-linkable protein or polypeptide and a solution of a non-toxic cross-linking material which induces cross-linking of said cross-linkable protein, thereby sealing at least a portion of the biological system.05-12-2011
20100222810METHODS AND DEVICES FOR DELIVERING INJECTIONS - Septal defect occluders are disclosed which can be used with a catheter deployment system to occlude a septal defect. The septal defect occluders of the present invention comprise a metallic frame structure that supports a biodegradable member. The frame structure is made from a shape memory metal such as Nitinol. The frame forms two opposing umbrella or disc shaped halves that are connected via a central region. The biodegradable member is attached to the umbrella or disc shaped halves and can be any of numerous biodegradable materials and is preferably a co-polymer of glycolide and lactide. This material initially forms a barrier to blood flow that occludes the defect. Over time, this material is replaced by the body with scar tissue formation and endothelial cells. The metal frame is left coated with the body's own material that blocks the defect.09-02-2010
20090062844SPIDER PFO CLOSURE DEVICE - A device for occluding septal defects or other bodily passageways including PFOs, includes an occluding body formed from a plurality of flexible outwardly radiating occluding wires connected to one or more biocompatible sheet materials. The occluding wires are joined together at proximal wire ends. Linking members connectively link the occluding body to a flexible, substantially linear anchor formed from at least one tube, coil, or bar. The anchor is configured for placement on one side of bodily passageway, whereby the longitudinal axis of at least one anchor extends across a transverse cross-section of the bodily passageway, anchoring the occluding body in place against the other side of a bodily passageway to close, occlude, or fill at least a lumenal portion of a bodily passageway. The anchor may include one or more grasping member(s) integrally formed or connected to the tube, coil, or bar for releasable attachment to an anchor engaging member, such as a biopsy forceps. In a further aspect, a closure device assembly includes a delivery catheter housing a collapsibly disposed closure device linked to a biopsy forceps. The biopsy forceps may be positioned in a locking catheter, which is configured to prevent inadvertent release of the closure device when held in a compressed state inside the delivery catheter. By positioning the catheter near a bodily passageway, such as a PFO, and disengaging the anchor engaging member from the grasping member, the closure device may be released so as to facilitate stable closure of the bodily passageway.03-05-2009
20130218202Sealing Device and Delivery System - The invention relates to a sealing device for repair of cardiac and vascular defects or tissue opening such as a patent foramen ovale (PFO) or shunt in the heart, the vascular system, etc. and particularly provides an occluder device and trans-catheter occluder delivery system. The sealing device would have improved conformity to heart anatomy and be easily deployed, repositioned, and retrieved at the opening site.08-22-2013
20130218203APPARATUS FOR CLOSING VASCULAR PUNCTURE - A method and apparatus for closing a vascular wound includes a guidewire and/or other surgical implement extending from the wound. A hemostatic material is advanced over the surgical implement and into contact with an area of the blood vessel surrounding the wound. The surgical implement is removed. Blood soaks the hemostatic material, and blood clotting is facilitated by the hemostatic agent within the material. A sealing layer of adhesive can be applied to the hemostatic material, confining the blood flow to the material. The vascular puncture wound is sealed by natural blood clot formation.08-22-2013
20100137902BIOADHESIVE CONSTRUCTS - The invention describes substrates, such as prosthetics, films, nonwovens, meshes, etc. that are treated with a bioadhesive. The bioadhesive includes polymeric substances that have phenyl moieties with at least two hydroxyl groups. The bioadhesive constructs can be used to treat and repair, for example, hernias and damaged tendons.06-03-2010
20120143243CLOSURE DEVICES - One or more embodiments of the present disclosure include a closure device, a method of making the closure device and a system that includes the closure device for closing an opening in a body lumen. The closure device includes an intravascular anchor for positioning in the body lumen, a suture coupled to the intravascular anchor, the suture to pass through the opening in the body lumen, a fastener joined to the suture, where the fastener moves longitudinally along the suture, and a plug having a first plug segment and a second plug segment. In one or more embodiments, the second plug segment has a hardness greater than the first plug segment, where the suture passes through the plug with the first plug segment between the intravascular anchor and the second plug segment and the second plug segment between the first plug segment and the fastener.06-07-2012
20100198254VASCULAR CLOSURE DEVICE - A device for closure of an opening formed through a wall of a body vessel of a patient is provided, as well as an introducer system for delivery of the closure device. Various embodiments include the closure device having hook members configured to engage the tissue interior of the body vessel wall, hook members configured to engage interstitial tissue adjacent to the body vessel, a plug member to contact sealably the opening from inside the body vessel, and combinations thereof. A retraction member is removably attached to the each of the embodiments to permit manipulation of the device. Remodelable material may be included with each of the embodiments to promote quicker healing. The introducer includes a sheath that is insertable through the opening and a pusher disposed within the lumen of the sheath and movable within the sheath lumen to deploy the device.08-05-2010
20120245623DEVICE AND METHOD FOR OCCLUDING A SEPTAL DEFECT - A device for occluding a septal defect is provided. In general, the occluding device has a contracted state that allows the occluding device to be received within a delivery device for deployment to the site of the defect and an expanded state that is achieved when the occluding device is deployed from the delivery device. The occluding device has a proximal portion, which may be substantially circular, a distal portion, which may be substantially ovaloid, and a connecting portion extending between the two. The distal portion may define first and second outer parts at opposite ends of the major axis, which may be bent or curved. The configuration of the proximal and distal portions allow the occluding device to securely engage the septal wall and be kept in position at the septal defect without causing substantial interference with the functioning of adjacent heart structures.09-27-2012
20090254119Vascular Closure Methods and Apparatuses - A vascular closure device comprised of a sheath-delivered expandable, umbrella-like device with structural radial members with terminal and non-terminal hooks that engage the vessel wall. Unlike other vascular closure umbrella-type devices that effect closure by opening of the umbrella to cover an opening, the present invention effects closure of the aperture with closure of the umbrella. The closure can be maintained by a retainer lock that slides down the members, causing contraction, bringing the members into a compressed configuration (e.g., a parallel orientation of linear members) and the wound edges together, permitting immediate vascular closure and healing of the blood vessel. The device can be delivered and recovered by an intravascular sheath.10-08-2009
20090318956Wire-Like And Other Devices For Treating Septal Defects And Systems And Methods For Delivering The Same - Systems, devices and methods for treating internal tissue defects, such as septal defects, with implantable devices are provided. In some exemplary embodiments, these devices include one or more wires coupled together. The device can include deflectable anchors for engaging the septal tissue.12-24-2009
20090318955VASCULAR CLOSURE DEVICE - The present invention provides a porous structure that works very effectively to seal a puncture site with optimum porosity, absorbent capacity and perfect anatomical fit. The plug density and other fiber properties/geometry (total denier; number of filaments; etc) have provided an efficient structure that allows instantaneous absorption of blood during deployment. The final size of the plug with absorbed fluids provides an anatomical fit and seals the puncture site within few minutes after deployment.12-24-2009
20120143242Sealing Device and Delivery System - The invention relates to a sealing device for repair of cardiac and vascular defects or tissue opening such as a patent foramen ovale (PFO) or shunt in the heart, the vascular system, etc. and particularly provides an occluder device and trans-catheter occluder delivery system. The sealing device would have improved conformity to heart anatomy and be easily deployed, repositioned, and retrieved at the opening site.06-07-2012
20130131717DEVICES AND METHODS FOR OCCLUDING ABNORMAL OPENINGS IN A PATIENT'S VASCULATURE - A medical device is provided in which one or both ends of the device encourage the formation of tissue across substantially the entire area of the respective end that is exposed to the blood flow for reducing the risk of a thrombotic embolism. The medical device includes a tubular structure having at least one expanded volume portion and a tapered transition portion. The tubular structure may be made through the braiding of a number of strands, and a first end feature may be used to secure the proximal strand ends. The proximal strand ends may be secured via the proximal end of the first end feature, such that the tapered transition portion is formed over the circumferential surface of the first end feature, and only a proximal end surface (or a portion of the proximal end surface) of the first end feature is exposed to the path of flowing blood.05-23-2013
20130131718EXPANDABLE DEVICE SHEATH FOR VASCULAR CLOSURE PLUG DEPLOYMENT - The present disclosure relates generally to methods and devices for closing and/or sealing an opening in a vessel wall and/or an adjacent tissue tract. In some cases, the device includes a sheath having a distal end that can expand radially as needed. In some cases, the distal portion of the sheath is weakened so that it may tear in a predetermined manner. In some cases, the distal portion of the sheath is weakened so that it may deform plastically in a predetermined manner. In some cases, the distal portion of the sheath or the entire sheath may be folded so that it unfolds in a predetermined manner. In general, each of these sheaths may have a relatively small introduction profile, may have a distal portion that can expand to a larger diameter than the introduction profile during use, and can be collapsed again to a smaller profile for removal.05-23-2013
20130131719WOUND CLOSURE DEVICES AND SYSTEMS - Methods and devices are provided for closing a puncture wound. In one exemplary embodiment, a puncture closure device is provided having an elongate tubular body that is disposable through a puncture in tissue and that includes proximal and distal portions. The proximal portion can be adapted to expand to form proximal wings upon rotation of the elongate tubular body, preferably in a first direction. The distal portion can be adapted to expand to form distal wings upon rotation of the elongate tubular body, preferably in a second, opposite direction. The proximal and distal portions can also be adapted to be moved toward one another as they expand upon rotation. As a result, the proximal and distal wings can engage tissue therebetween.05-23-2013
20130131721LOCKABLE ATTACHMENT AND STYPTIC DEVICE INCLUDING SAME - A lockable flexible element including an attachment and a substantially elongated and flexible body defining a body first end and a substantially opposed body second end, the body defining a body serrated surface substantially longitudinally spaced apart from the body second end. The attachment includes a collar provided substantially adjacent the body second end; a tongue provided at least partially inside the collar and extending substantially longitudinally thereinto, the tongue defining a tongue serrated surface, the tongue being deformable between a tongue extended configuration and a tongue retracted configuration; and a safety catch removably insertable between the tongue and the collar with the tongue between the body serrated surface and the safety catch.05-23-2013
20130190809PROCEDURAL SHEATH SECUREMENT DEVICE AND METHODS - A procedural sheath holding device includes a base member and a securing member. The base member is positionable in contact with an outer skin surface adjacent to an incision. The securing member is attached to the base member and includes a securing portion operable to releasably secure a procedural sheath in a fixed axial position relative to the skin surface when a vascular closure device is inserted through the procedural sheath to seal the incision. The securing member may be pivotal relative to the base member.07-25-2013
20090036920CLOSURE DEVICE - A medical closure device (02-05-2009
20090036919CLOSURE DEVICE - A medical closure device (02-05-2009
20130138144TISSUE CLOSURE DEVICE - A tissue closure device including a hub and first and second flanges extending therefrom. The hub extends along a central longitudinal axis between a proximal surface and an opposing distal surface. The first flange is frameless and extends from the hub adjacent the proximal surface thereof. The second flange extends from the hub adjacent the distal surface thereof. The first and second flanges are moveable between: a closed position, in which the first and second flanges extend radially away from the hub and are substantially orthogonal to the central longitudinal axis; and an open position, in which the first and second flanges extend longitudinally away from the hub in opposite directions from each other and are substantially parallel with the central longitudinal axis.05-30-2013
20130138145TISSUE CLOSURE DEVICE WITH RESILIENT ARMS - A tissue closure device includes a main body, a sheath, and a biasing member. The main body has a plurality of resilient arms that each extend from a proximal end to a distal tip. The resilient arms are movable between an open configuration in which the distal tips are radially spaced apart from the longitudinal axis of the main body and from each other and a closed configuration in which the distal tips abut one another at or near the longitudinal axis. The sheath is longitudinally slideable on the main body to move the arms between the open and closed configurations. The biasing member causes the sheath to bias the arms toward the closed configuration.05-30-2013
20130138146PUNCTURE REPAIR KIT - A puncture repair kit has a bottle unit positioned with greater stability. A puncture repair kit includes a compressor device, and a bottle unit in which a cap is attached to an opening in a bottle container which houses a puncture sealing agent. The compressor device includes a compressed air discharge port. The cap includes an air intake port for feeding compressed air from the compressed air discharge port into the bottle container, and a sealing agent/compressed air removal port for removing puncture sealing agent and compressed air in succession from the bottle container by feeding in compressed air. When the cap of the bottle unit is oriented downwards, the air intake port is directly connected with the compressed air discharge port. When this direct connection is made, the basal plane of the cap and the basal plane of the compressor device are flush with each other.05-30-2013
20130138147Apparatus and Methods for Facilitating Hemostasis within a Vascular Puncture - Apparatus for sealing a puncture communicating with a blood vessel includes a bioabsorbable sealing member secured to one end of a filament or other retaining member. The sealing member is delivered through the puncture into the vessel, and refracted against the wall of the vessel to provide temporary hemostasis. The sealing member is rapidly absorbed after exposure within the vessel, e.g., to an aqueous or heated physiological environment (e.g., exposure to blood or body temperature), immediately or shortly after completing a medical procedure via the puncture, e.g., within the time period that the patient is ambulatory. Optionally, extravascular sealing material is delivered into the puncture proximal to the sealing member. The retaining member and/or extravascular material may be bioabsorbable, being absorbed at a slower rate than the sealing member. Alternatively, the filament is removed from the puncture after hemostasis is established.05-30-2013
20130144332Curved Arm Intracardiac Occluder - Disclosed herein are devices and methods for occluding intracardiac defects, for example, a patent foramen ovale (PFO). The devices according to the invention have various features that enhance the flexibility of the device and improve the device's ability to conform to the location of the intracardiac defect. In particular, intracardiac occluders with curved arms are disclosed.06-06-2013
20110029014MEDICAL CLOSURE DEVICE - A medical closure device (02-03-2011
20110213415VASCULAR HOLE CLOSURE DEVICE - A device for closing an aperture in a vessel wall, the aperture having an external opening in an external region of the vessel wall and an internal opening in an internal region of the vessel wall. The device includes a covering member positionable inside the vessel against the internal opening of the aperture and having a dimension to prevent egress of fluid through the aperture. A securing member is positionable external of the vessel and has a plurality of pores extending therethrough. A flexible connecting member operatively connects the covering member and securing member and moves the securing member toward the covering member.09-01-2011
20110213412APPARATUS FOR VESSEL ACCESS CLOSURE - Embodiments are described for closing vascular access ports, such as arteriotomies, which involve placement and deployment of an expandable device configured to prevent blood flow across a subject arteriotomy while also keeping disturbance of intravascular flow to a minimum. Suitable prostheses may comprise one or more frames constructed from lengths of flexible materials, such as shape memory alloys or polymers. Such frames may be coupled to sheetlike or tube-like structures configured to spread loads, minimize thrombosis which may be related to intravascular flow, and maintain hemostasis.09-01-2011
20110213411METHOD FOR VESSEL ACCESS CLOSURE - Embodiments are described for closing vascular access ports, such as arteriotomies, which involve placement and deployment of an expandable device configured to prevent blood flow across a subject arteriotomy while also keeping disturbance of intravascular flow to a minimum. Suitable prostheses may comprise one or more frames constructed from lengths of flexible materials, such as shape memory alloys or polymers. Such frames may be coupled to sheetlike or tube-like structures configured to spread loads, minimize thrombosis which may be related to intravascular flow, and maintain hemostasis.09-01-2011
20110213410METHOD FOR VESSEL ACCESS CLOSURE - Embodiments are described for closing vascular access ports, such as arteriotomies, which involve placement and deployment of an expandable device configured to prevent blood flow across a subject arteriotomy while also keeping disturbance of intravascular flow to a minimum. Suitable prostheses may comprise one or more frames constructed from lengths of flexible materials, such as shape memory alloys or polymers. Such frames may be coupled to sheetlike or tube-like structures configured to spread loads, minimize thrombosis which may be related to intravascular flow, and maintain hemostasis.09-01-2011
20110009901METAL VASCULAR APERTURE CLOSURE DEVICE - A closure device to be inserted at least partially through a blood vessel wall aperture in a blood vessel wall. The closure device includes at least two parts, an internal part and an external part. The internal part is adapted to be extended at least partially through the blood vessel wall aperture and into the lumen to at least partially block the blood vessel wall aperture. Each of the internal part and the external part consists essentially of a metal that biodegrades within a living being in a period of time that permits biological repair of the blood vessel wall in and around the blood vessel aperture.01-13-2011
20110213413ANEURYSM SENSING DEVICES AND DELIVERY SYSTEMS - A system for gaining access to an interventional site within vasculature through a vessel wall or other structure such as that of a medical device. An apparatus is provided to accomplish a sealed worksite as are sensor delivery systems including sealable sensor devices that are adapted to be placed at the interventional site.09-01-2011
20110029012DUAL HYPOTUBE SUTURE CUTTING DEVICE AND METHODS - A tissue puncture closure device includes an anchor, a sealing pad, a compaction member, a suture, and a suture cutting member. The compaction member is configured to compress the sealing pad toward the anchor. The compaction member includes a sidewall and a first aperture defined in the sidewall. The suture cutting member is positioned in the compaction member and includes a suture cutting member sidewall and a second aperture defined in the suture cutting member sidewall. The suture is coupled to the sealing pad and anchor, and a portion of the suture extends through the first and second apertures. Relative movement between the compaction member and the suture cutting member severs the suture.02-03-2011
20100179588VASCULAR PUNCTURE CLOSURE SYSTEM WITH GUIDE SHEATH STABILIZER - A guide sheath for use in guiding a vascular puncture closure device to and in registry with a vascular puncture includes a stabilization system having retention wires deployable from the sheath and engageable with the vessel wall. The retention wires pierce the vessel wall at spaced locations, proximally and distally, about the puncture and form anchors to retain the sheath in registry with the puncture.07-15-2010
20100179589RAPIDLY ERODING ANCHOR - An anchor for using a closure device includes a body being configured to move from a pre-deployed state to a deployed state. In the pre-deployed state, the body has a first width aspect relative to a direction of deployment and a second width aspect in the deployed state relative to the direction of deployment, the second width aspect being greater than the first width aspect and wherein the body is formed from a rapidly eroding material configured to erode through dissolution within a body lumen.07-15-2010
20090062848CLOSURE MEDICAL DEVICE - A closure device for closing a puncture wound has a distal section that can be placed against the interior wall of a vessel and a proximal section that bunches in the tissue tract to close the wound. One variation of the device provides for removing the distal section from the vessel so that it resides also in the tissue tract after the proximal section has been securely bunched and lodged within the tissue tract in order to provide unobstructed fluid flow in the vessel.03-05-2009
20090062847CLOSURE MEDICAL DEVICE - A closure device for closing a puncture wound has a distal section that can be placed against the interior wall of a vessel and a proximal section that bunches in the tissue tract to close the wound.03-05-2009
20110245867Haemostatic Kit, A Method of Preparing A Haemostatic Agent and a Method of Promoting Haemostatis - A haemostatic kit to be used as a medical device provides for a containment unit and a haemostatic agent in said containment unit, said haemostatic agent occupying less than 90% of the volume of the containment unit. This allows for facile and consequently sterile preparation of, for instance, a gelatin paste for use in haemostatis when combined with saline, thrombin or another agent to assist in haemostatis.10-06-2011
20110245866METHOD AND APPARATUS FOR WOUND SEALANT APPLICATION - Devices and methods are disclosed for delivering sealing compound to a wound in animals, including humans. Such wound sealing is important after deep skin penetrating lacerations or subsequent to internal wounds. The apparatus utilize an aerosol dispensing system that both mixes and applies a multi-part sealant compound. The aerosol system includes a plurality of sealant component chambers, a source of pressurized gas, an aerosol mixing head, a pressure regulator, a pneumatic switch, and a component pumping mechanism. The aerosol system, either a reusable or a disposable device, is further provided with a system that keeps dry components from liquid components and then automatically mixes the liquid and dry components prior to application. The system provides for easy control over the application, inexpensive manufacture, and simplified preparation, thus minimizing the time needed for application and enhancing the potential outcomes of the patient.10-06-2011
20100234882CLOSURE DEVICES, RELATED DELIVERY METHODS AND TOOLS, AND RELATED METHODS OF USE - A device for sealing a patent foramen ovale (PFO) in the heart is provided. The device includes a left atrial anchor adapted to be placed in a left atrium of the heart, a right atrial anchor adapted to be placed in a right atrium of the heart, and an elongate member adapted to extend through the passageway and connect the left and right atrial anchors. The right atrial anchor preferably includes a plurality of arms and a cover attached to the arms. The left atrial anchor also includes a plurality of arms and preferably does not include a cover. Preferably, the elongate member has a first end of fixedly connected to the left atrial anchor and a portion, proximal to the first end, releasably connected to the right atrial anchor. Preferably, the elongate member is flexible.09-16-2010
20120245625WOUND CLOSURE DEVICES AND METHODS - Methods and devices are provided for closing a puncture wound. In one exemplary embodiment, a puncture closure device is provided having an elongate tubular body that is disposable through a puncture in tissue and that includes proximal and distal portions. The proximal portion can be adapted to expand to form proximal wings upon rotation of the elongate tubular body, preferably in a first direction. The distal portion can be adapted to expand to form distal wings upon rotation of the elongate tubular body, preferably in a second, opposite direction. The proximal and distal portions can also be adapted to be moved toward one another as they expand upon rotation. As a result, the proximal and distal wings can engage tissue therebetween.09-27-2012
20120245624SNAP-ON VASCULAR CLOSURE DEVICE AND METHODS - A tissue puncture closure assembly including a wire assembly and a sealing pad delivery device. The wire assembly includes a proximal end portion, a distal end portion, and a temporary expandable anchor positioned at the distal end portion. The sealing pad delivery device includes a carrier tube, a sealing pad positioned in the carrier tube, and a lateral wire slot. The lateral wire slot is defined in an outer surface of the sealing pad delivery device and extends along at least a portion of a length of the sealing pad delivery device. The lateral wire slot is configured to permit mounting of the sealing pad delivery device to the wire assembly in a lateral direction.09-27-2012
20090326577PHYSICALLY MODIFIED EXTRACELLULAR MATRIX MATERIALS AND USES THEREOF - Described are expanded collagenous materials and methods for their preparation and use. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.12-31-2009
20090216267CLOSURE DEVICE WITH RAPIDLY DISSOLVING ANCHOR - Closure devices with a rapidly dissolving anchor, systems delivering closure devices, and methods for making and using the same. An example closure device for closing an opening in a body lumen may include a plug, a rapidly dissolving anchor, and a suture coupling the plug to the anchor. The rapidly dissolving anchor may be configured to dissolve within the body lumen within about 30 days or less. At least a portion of the plug may be disposed adjacent an exterior surface of the body lumen. At least a portion of the rapidly dissolving anchor may be disposed within the body lumen.08-27-2009
20090216266TISSUE CLOSING DEVICE - A tissue closing device includes a closure configured to close a hole penetrating a tissue membrane. The closure has a seal part for covering a hole penetrating a tissue membrane and a peripheral part of the hole from one surface side of the tissue membrane, and a deformable deformation part. The tissue closing device also comprises an arrangement device which removably retains the closure and closes the hole with the closure so as to arrange the closure in a living organism.08-27-2009
20090216265Tissue fasteners and related deployment systems and methods - Surgical tissue fasteners and related deployment systems and methods are disclosed. A tissue fastener used to join multiple tissue layers includes a first member, a second member, and a connecting member connecting the first and second members. In some embodiments, the first and second members are configured to expand from a delivered state to a deployed state in which the fastener secures the tissue layers together. Other tissue fastener embodiments include means for applying a substantially constant force on the tissue layers and/or means for adjusting a length of the connecting member between the first and second members.08-27-2009
20090216264IMPLANTABLE CLOSURE APPARATUS AND METHODS - Implantable closure apparatus and methods for sealing or closing openings at internal body locations. The apparatus and methods may involve the delivery and attachment of a patch, patch and plug, or plug only to seal or close the opening. The closure apparatus and methods may be used to close a patent foramen ovale (PFO).08-27-2009
20110082496Endovascular device and clotting system for the repair of vascular defects and malformations - A device for sealing damaged and defective vessels utilizes a surgical wire or similar appliance positioned and housed within a protective sheath, such as a catheter or needle. Stable thrombin and non-thrombin based solutions, gels, or biological glues are then used to coat the tip of a surgical appliance, such as surgical wires and trocars, with concentrations sufficient to cause clotting. The protective sheath around the wire and a one way valve provides a barrier which prevents clotting material to insinuate itself into healthy tissue. The protective catheter containing the wire is then inserted into the body of the patient and directed to the damaged site. The wire is then partially extended out of the sheath to allow the clotting material to be applied and deposited onto the damaged vessel, thereafter the wire and sheath are safely withdrawn from the body of the patient.04-07-2011
20110087272Wound Closure Device - Biocompatible wound closure devices including an elongate body and a plug member are useful for wound repair.04-14-2011
20110087270Vasculature Closure Devices and Methods - Vasculature closure devices, and systems and methods for their use, are provided. In one embodiment, the vasculature closure device includes an expandable support frame deployable within a vessel and a sealing membrane at least partially supported by the expandable support frame. Upon expanding the support frame, the vasculature closure device is configured to intraluminally position the sealing membrane against a puncture site existing in a vessel wall.04-14-2011
20110087274Wound Closure Device - Biocompatible wound closure devices including an elongate body and a plug member are useful for wound repair.04-14-2011
20110082497METHODS AND DEVICES FOR STERNAL CLOSURE - A method for closing a sternum separated into at least a first sternum portion and a second sternum portion includes preparing at least one cut surface of at least one of the first or second sternum portions to have an adhesive applied thereon. The adhesive is applied to at least a portion of the at least one cut surface. The at least one cut surface is approximated to a second cut surface of the other of the first sternum portion or second sternum portion. As the adhesive cures, it bonds with the first cut surface and the second cut surface. Preparing the at least one cut surface may remove contaminants that could inhibit adhesion of the adhesive. The adhesive may be applied through adhesive injection holes formed along an incision separating the first and second sternum portions. Devices for preparing the cut surfaces and applying the adhesive are also provided.04-07-2011
20110082495Apparatus And Methods For Excluding The Left Atrial Appendage - Apparatus and methods are provided for excluding and reducing the volume of the left atrial appendage (“LAA”) by deploying a first tissue capture element in contact with the pericardium and a second tissue capture element in engagement with the endocardial surface adjacent to the ostium of the LAA, such that the LAA tissue is retained in a collapsed, reduced volume state therebetween. Methods of using the apparatus of the present invention to reduce or occlude the LAA also are provided.04-07-2011
20110152924OXIDIZED REGENERATED CELLULOSE ADHESIVE TAPE - A novel ORC adhesive tape is disclosed. Specifically, the ORC adhesive tape is useful as an alternative to conventional mechanical and non-mechanical wound closure means. The ORC tape has a tape substrate made from neutralized ORC and it contains an adhesive composition such as a bioabsorbable alpha-cyanoacrylate.06-23-2011
20110071565APPARATUS AND METHODS FOR PROVIDING TACTILE FEEDBACK WHILE DELIVERING A CLOSURE DEVICE - An apparatus for sealing a passage through tissue includes a tubular member, a plug, and a locator member. The plug is disposed on a distal end of the tubular member and includes an external thread. The locator member is inserted into a lumen of the tubular member until a distal portion is disposed beyond the plug. The distal portion includes a helically wound wire and a tether coupled to the wire that is movable for causing the wire to buckle. To seal a passage communicating with a blood vessel, the distal portion of the locator member is inserted into the passage, and the plug is threaded into the passage until the distal portion extends into the vessel. The tether is pulled to buckle the wire, and the plug is unthreaded until the buckled wire contacts a wall of the vessel, whereupon the plug is released to seal the passage.03-24-2011
20110077683PUNCTURE CLOSURE APPARATUSES, SEALING PLUGS, AND RELATED METHODS - A puncture closure device is disclosed. Particularly, a puncture closure device may include an anchor support including a coupling feature and an anchor connected to the anchor support. Further, the puncture closure device may include a movable compression element configured to compress a sealing plug generally between the compression element and the anchor. Such a puncture closure device may be positioned at least partially within an insertion sheath to form a puncture closure assembly. A method of compressing a sealing plug and a method of sealing a puncture are disclosed. In addition, in one embodiment, a sealing plug may comprise a first, a second, and an intermediate end region, wherein the intermediate region has a density less than the first and second end regions. In another embodiment, a sealing plug may include a bore formed therethrough and a plurality of slits formed into an exterior surface of the sealing plug.03-31-2011
20110077682Hemorrhage Control Devices and Methods - The present invention is directed to a composition comprising a plurality of small, liquid-expandable articles and their use to induce hemostasis when applied to bleeding wounds.03-31-2011
20120035653MODIFIED PLUG FOR ARTERIOTOMY CLOSURE - The disclosure provides a modified arteriotomy closure plug, the modification consisting of subjecting a bioabsorbable foam closure plug to radial compression and/or axial bending until at least some struts of the foam have been torn or elongated within at least one axially disposed region.02-09-2012
20110071566METHODS, DEVICES, KITS AND SYSTEMS FOR DEFUNCTIONALIZING THE CYSTIC DUCT - The application discloses devices, systems, kits and methods for treating biliary disease. Devices comprise, for example, a component configurable for deployment between within a cystic duct of a patient which has a proximal end and a distal end. In some embodiments, a lumen may also extend therethrough.03-24-2011
20120203273Systems and Methods for Closing a Tissue Opening - The present invention is directed to tissue closure devices for closing a tissue opening, including one or more closure components, each closure component having a first member and a second member, each of the first and second members having a first surface that adheres to a tissue surface proximate to the tissue opening, each of the first and second members having a second surface substantially orthogonal to the first surface, and each of the first and second members having a transitional region between the first surface and the second surface which is contoured to evert an edge of the tissue opening upon the drawing together of the first and second members. The present invention is also directed to systems and kits, dressing systems, and methods for tissue repair and closure.08-09-2012
20120123468Wire-Like and Other Devices for Treating Septal Defects and Systems and Methods for Delivering the Same - Systems, devices and methods for treating internal tissue defects, such as septal defects, with implantable devices are provided. In some exemplary embodiments, these devices include one or more wires coupled together. The device can include deflectable anchors for engaging the septal tissue.05-17-2012
20120123467DEVICE AND METHOD FOR DISPENSING A MATERIAL WITH THERMOPLATIC PROPERTIES IN A FLOWABLE STATE AT AN OPERATION SITE IN A HUMAN OR ANIMAL PATIENT - For dispensing a material with thermoplastic properties in a flowable state at an operation site in a human or animal patient, a device is used, which includes the material having thermoplastic properties in a solid state and is equipped for bringing the material into a flowable state at a distal device end positioned at the site where dispensing is desired and for driving the flowable material from this distal device end. The device comprises a rotation drive, a consumable element and a dispenser element, wherein one of the two elements is coupled to the rotation drive and wherein the consumable element comprises the material to be dispensed. The two elements are arranged with parallel longitudinal axes and the dispenser element comprises a distal end piece with a proximal face against which a distal face of the consumable element is held and advanced during dispensing.05-17-2012
20110060361RECONSTITUTION AND APPLICATOR SYSTEM FOR WOUND SEALANT PRODUCT - A system for mixing or reconstituting agents including engageable syringe barrels, one of which having a male engagement region and the other a female engagement region. Each of the male and female engagement regions is provided with a screen. The screens are closely spaced from one another when the first and second syringe barrels are engaged with one another. The screens may take the form of a mesh, a plurality of protuberances, or cantilevered wedges having tapering thicknesses.03-10-2011
20120303056Thermosetting Shape Memory Polymers with Ability to Perform Repeated Molecular Scale Healing - A composition comprising thermoset shape memory polymer and a composition for molecular scale healing is disclosed; the composition has the ability to resolve structural defects by a close-then-heal mechanism. In use the shape memory polymer serves to bring opposing surfaces in a structural defect into proximity, whereafter heating the molecular scale healing composition to a level at or above its melting point allows for molecular scale healing. The composition has the ability to close macroscopic defects, and to do so repeatedly even if another wound occurs in a previously healed area.11-29-2012
20110034953SURGICAL STAPLING SYSTEMS - Interengaging surgical staples (02-10-2011
20100298866WOUND CLOSURE SYSTEM AND METHOD OF USE - Accordingly, a wound closure system for closing a puncture wound is provided. The system includes a housing for maintaining a vacuum about a wound, a sealing assembly including a working instrument having a distal end configured to be inserted through the housing and into the wound, wherein the working instrument is further configured to close and seal the wound as the working instrument is withdrawn therefrom.11-25-2010
20120277791Devices and Methods for Closure of a Patent Foramen Ovale - The present invention provides devices and methods for closing a physical anomaly comprising two overlapping layers of tissue, such as a patent foramen ovale (“PFO”). A PFO is comprised of two overlapping layers of malformed interatrial septa, the septum primum and the septum secundum, that form a tunnel between the right atrium and the left atrium. The closure device includes two wings connected to a central arm. The device is delivered through the PFO tunnel in a substantially linear configuration such that the central arm is seated within the PFO tunnel, the first wing extends into the right atrium, and the second wing extends into the left atrium. Once implanted, the closure device is reconfigured such that the arm is seated within the PFO tunnel, the first wing folds against the septum secundum, and the second wing folds against the septum primum, thereby sealing the defect.11-01-2012
20090292309System and workflow for diagnosing and treating septum defects - A system, method and workflow is described that may be used for the treatment of a patient having a cardiac syndrome characterized by an unwanted aperture in a structure of the heart. Images of the patient are obtained with a C-arm X-ray device, and the images are used to determine the size and location of the aperture. A catheter is used to insert an occluder into the patient and emplace the occluder in the aperture so as to close the aperture. The occluder may be guided using one of fluoroscopic images from the C-arm X-ray device, acoustic or magnetic sensors. Diagnosis of the syndrome and the minimally interventional treatment may be performed by the same treatment suite.11-26-2009
20080243182Vascular hemostasis device and deployment apparatus - A hemostasis device for percutaneously sealing a puncture in the wall of a blood vessel includes a rigid post, and a foot, a seal and a retaining member mounted on the rigid post. The hemostasis device may be deployed in the puncture so that the foot is positioned within the blood vessel. Tension is applied to the rigid post to hold the foot against the inside surface of the blood vessel. The retaining member is then pushed along the length of the rigid post, advancing the seal to a deployed state against the outside surface of the blood vessel. The puncture in the blood vessel is sandwiched between the foot and the seal in the deployed state. The rigid post, foot, seal and retaining member may all be formed from a resorbable polymeric material.10-02-2008
20110160765METHODS AND DEVICES FOR TREATMENT OF FISTULAS - This invention relates to methods and devices utilizing minimally invasive techniques for digestive system fistula closure using occluder devices and various securing and sealing means. The present subject matter expands upon the breadth of current endoscopic techniques by implementing novel occluder devices and techniques intended specifically for treatment of digestive fistulas.06-30-2011
20110257682MEDICAL DEVICES INCORPORATING FUNCTIONAL ADHESIVES - Methods for treating a wound at a surgical target site are provided which includes utilizing a surgical access device having a plurality of reactive members of a specific binding pair releasably contained on a surface of the access device, the reactive members having affinity for binding a cellular component of tissue cells located at the target site; contacting the surface of the access device with the tissue cells, wherein upon contact of the reactive members on the surface of the access device with the tissue cells, the reactive members are released from the surface of the access device and bind to the tissue. A surgical access device for use in the minimally invasive surgery is also provided.10-20-2011
20080215085Compliant Electrode for Patent Foramen Ovale Closure Device - A medical device for use in delivering RF energy to a tissue opening is disclosed. In one embodiment, the medical device comprises a compliant electrode. The compliant electrode can include a shape memory material, such as NITINOL, to facilitate the electrode having at least one relaxed orientation. The electrode can be deployed from a delivery shaft inside the left atrium, for example, of a heart through the delivery shaft. The electrode can be configured to substantially conform to the tissue proximate the tissue opening. After energy is applied to the tissue between the left and right electrodes, the left electrode can be removed from the left atrium by being received back into the delivery shaft and the delivery shaft thereafter removed from the opening.09-04-2008
20080215086SINGLE DISC INTRALUMINAL FIXATION PATENT FORAMEN OVALE CLOSURE DEVICE - A device and method for deploying a mechanical closure device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart. The single disc mechanical closure device is comprise of a distal and proximal anchor constrained by a closure line to facilitate mechanical closure by bringing the distal and proximal anchors into close proximity along the closure line.09-04-2008
20110054520Devices and Methods for Occluding a Fistula - A method of occluding a fistula in a patient is provided. The method includes inserting a placement member having a coupling structure, such as a wire guide having a loop at one end, through the primary opening of a fistula and at least partially into the fistula tract; connecting the coupling structure to a medical device, such as a plug, graft, or other occluding member; and inserting the medical device into the fistula by pulling the placement member through the fistula until the medical device contacts the interior wall of the fistula. Medical devices and systems for occluding fistulas are also provided.03-03-2011
20110054519DEVICE FOR CLOSING DEFECTS IN THE VASCULAR SYSTEM - The invention relates to a self-expanding device, particularly an implant, for closing defect openings in the human or animal body, which device, in a first state, has the shape of an elongated tube (03-03-2011
20110054518BURR HOLE SEALING DEVICE FOR PREVENTING BRAIN SHIFT - A burr hole sealing device for preventing brain shift during a stimulation lead implantation procedure is provided. The device includes a suction cup ring and a self-sealing membrane positioned within the aperture of the ring. The sealing device is attached adjacent to a burr hole and over a dura layer that is exposed in the bottom of the burr hole. The stimulation lead is disposed through the burr hole, through the membrane, through the dura layer and into brain tissue. The membrane is configured to allow the lead to pass therethrough while maintaining a tight seal around the diameter of the lead, thereby hindering leakage of cerebrospinal fluid out of the cranial cavity and maintaining a substantially fixed intracranial pressure. In one embodiment, the sealing device includes a syringe for adding fluid to, or removing fluid from, the cranial cavity in response to a detected change in intracranial pressure.03-03-2011
20110022080SINGLE DISC INTRALUMINAL FIXATION PATENT FORAMEN OVALE CLOSURE DEVICE - A device and method for deploying a mechanical closure device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart. The single disc mechanical closure device is comprise of a distal and proximal anchor constrained by a closure line to facilitate mechanical closure by bringing the distal and proximal anchors into close proximity along the closure line.01-27-2011
20110022081HEMOSTASIS-ENHANCING DEVICE AND METHOD FOR ITS USE - The present invention advantageously provides devices, systems, and methods for percutaneous access and closure of vascular puncture sites. In an embodiment, the device for enhancing the hemostasis of a puncture site in a body lumen or tract comprises a catheter having one tubular member having a proximal end and a distal end with one inner lumen extending between at least a longitudinal portion of the catheter tubular member. The one tubular member includes external and internal tubular bodies each having proximal and distal ends. At least one of the external and the internal tubular bodies is longitudinally movable with respect to the other. An expansible member with proximal and distal ends is disposed on the distal end of the one tubular member. The distal end of the expansible member is connected to the distal end of internal tubular body and with its proximal end connected to the distal end of external tubular body.01-27-2011
20110029013Vascular Hole Closure Device - A device for closing an aperture in a vessel wall comprising a covering member having a longitudinal axis and positionable inside the vessel against the internal opening of the aperture and having a dimension to prevent egress of fluid through the aperture and having a first opening. A first retainer is positionable external of the vessel. A flexible connecting member operatively connects the covering member and the first retainer, wherein the first opening of the covering member is configured to restrict movement of the connecting member.02-03-2011
20110112572Hemostatic Tapes and Dispensers Therefor - The present disclosure relates to tapes and tape dispensers. The tapes include a porous substrate, a first hydrogel precursor, a second hydrogel precursor and a release sheet. The first and second hydrogel precursors are applied to the porous substrate. The release sheet is removably attached on the porous substrate.05-12-2011
20100292729Delivery System for Magnetic Anastomosis Device - A magnet delivery system for forming an anastomosis that comprises a wire guide; a catheter having a delivery portion for advancement into a visceral space, the delivery portion having a lumen extending at least partially therethrough and an expandable balloon for dilation and a lumen extending therethrough, a first port and a second port in communication with the lumen through which the wire guide is disposed; a magnet comprising a lumen therethrough wherein the magnet is removably secured to the delivery portion of the catheter between the first and second ports by disposing the wire guide through the lumen of the magnet, the first port and the second port.11-18-2010
20110125186FOAM INTRODUCTION SYSTEM INCLUDING MODIFIED PORT GEOMETRY - A surgical apparatus for positioning within a tissue tract accessing an underlying body cavity includes a seal anchor member including leading portion, a trailing portion, and an intermediate portion disposed between the leading and trailing portions. The leading portion of the seal anchor member is configured and adapted to ease insertion of the seal anchor member into the tissue tract. Subsequent to insertion of the seal anchor member, the leading portion of the seal anchor member is also configured and adapted to facilitate securing and/or anchoring of the seal anchor member within the tissue tract.05-26-2011
20110125185Wound Plugs - A medical device for wound closure, including an elongate body with a plurality of portions and a perforated region disposed therebetween. The medical device may also include an alignment member. The wound plug may also have a first position for insertion, the portions being mechanically coupled to each other, and a second position where one or more of the portions are spatially separated.05-26-2011
20100262183SYSTEMS DEVICES AND METHODS FOR ACHIEVING TRANSVERSE ORIENTATION IN THE TREATMENT OF SEPTAL DEFECTS - Systems, devices and methods for treating internal tissue defects, such as septal defects, with implantable devices are provided. Elongate delivery systems for these implantable devices are configured to achieve a transverse orientation with respect to the defect site, allowing the implantable apparatus to be delivered from an elongate device in an efficient manner.10-14-2010
20100324595DEVICES FOR REDUCING THE SIZE OF AN INTERNAL TISSUE OPENING - A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The closure device can include a body portion operatively associated with a first anchor and a second anchor. The body portion can include a plurality of segments defining a multi-cellular structure. The closure device can be configured to apply lateral force to tissue of the internal tissue opening to bring tissue together. The closure device can have a substantially flat aspect, and have a depth thickness that is substantially greater than the thickness or width of a majority of the members forming the closure device to reduce out of plane bending. The closure device can also include a member adapted to induce tissue growth.12-23-2010
20100185234CLOSURE DEVICES, SYSTEMS, AND METHODS - The present disclosure includes vessel closure devices, systems, and methods. A closure device configured to close an opening in a body lumen may include an elongate member having a distal end and a proximal end. An anchor member may be disposed on the elongate member proximate the distal end of the elongate member. A cap member may also be disposed on the elongate member a distance from the distal end of the elongate member. The anchor member and the cap member cooperate to close the opening in the body lumen.07-22-2010
20090171386PERCUTANEOUS CATHETER DIRECTED INTRAVASCULAR OCCLUSION DEVICES - Embodiments of the present invention provide an improved vascular occlusion device for occlusion of a passageway, cavity, or the like. According to one embodiment, a medical device for occluding a left atrial appendage is provided. The medical device includes a first portion having at least one plane of occlusion that is configured to be positioned outside of the left atrial appendage, and a second portion having at least one plane of occlusion that is configured to be at least partially positioned within a cavity defined by the left atrial appendage.07-02-2009
20090171387VASCULAR CLOSURE DEVICE HAVING AN IMPROVED PLUG - Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. The vascular closure device includes an improved plug that is configured to be positioned adjacent to the hole in the vasculature. The plug may be shaped to prevent the plug from moving away from the hole in the blood vessel due to pulsatile pressure from the blood. In one embodiment, the plug may include a plurality of projections that extend outward from the plug and contact surrounding tissue in the tissue puncture tract to prevent the plug from moving away from the hole in the blood vessel.07-02-2009
20110137338Hemostatic Device and Its Methods of Use - A hemostatic device is provided for sealing a puncture of a vessel. The hemostatic device includes a locator device and an injection tube coupled to the locator device. The locator device includes a device valve that is actuatable to selectively restrict access to a portion of the locator device. The hemostatic device is advanced into the vessel until a first fluid is channeled through the locator device. The device valve is actuated to selectively restrict the first fluid from being channeled through the locator device. A second fluid is injected through the injection tube to facilitate sealing a puncture of the vessel. The hemostatic device is withdrawn from the vessel.06-09-2011
20100082061APPARATUS AND METHOD FOR DRIVING A HEMORRHAGE OCCLUDER PIN INTO A HUMAN SACRUM - A method and apparatus to terminate sacral hemorrhaging in a patient having a sacrum and a pubic bone is disclosed and claimed. A C-shaped driver is positioned around the pubic bone of the patient and a hemorrhage occluder pin is driven into the sacrum of the patient by applying an impact force to a proximal end of the C-shaped driver. The driver includes a C-shaped shaft that defines a radius in the range 50 mm to 200 mm and a maximum span in the range 100 mm to 650 mm. A proximal end is attached to the C-shaped shaft. The proximal end has a blunt face with a breadth that is at least 2.5 times the diameter of the pin cap. A shaft distal end has a driver face defining a driver face diameter that is no less than 50% of the pin cap diameter.04-01-2010
20100191280TISSUE PUNCTURE CLOSURE DEVICE WITH MAGAZINE FED TAMPING SYSTEM - The present invention is directed to methods and apparatus for sealing a puncture or incision formed percutaneously in tissue separating two internal portions of the body of a living being with an anchor, a sealing plug and a filament connecting the anchor and sealing plug. The method and apparatus provide a magazine fed tamping system for automatic tamping and/or cinching of the sealing plug when the apparatus is withdrawn from the puncture site. The automatic tamping and/or cinching is facilitated by transducing a motive force generated by the withdrawal of the apparatus into a tamping and/or cinching force.07-29-2010
20110190812FIBRINOGEN-BASED TISSUE ADHESIVE CONTAINING AN ELASTASE INHIBITOR - The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.08-04-2011
20110190811SYSTEM AND METHOD FOR PROVIDING ACCESS AND CLOSURE TO TISSUE - Embodiments are described for creating and closing tissue access ports or defects, such as transapical access ports, which involve placement of an elongate prosthesis in a helical configuration across the tissue structure site to be crossed, and confirmation that such helical suture configuration is positioned appropriately, before further interventional steps. A plug member may be included to assist with closure of the ports of defects. The elongate prosthesis and plug member may comprise bioresorbable materials.08-04-2011
20100023051TISSUE PUNCTURE CLOSURE METHOD WITH DISENGAGABLE AUTOMATIC TAMPING SYSTEM - A method and apparatus for sealing a puncture or incision formed percutaneously in tissue separating two internal portions of the body of a living being with an anchor, a sealing plug and a filament connecting the anchor and sealing plug. The method and apparatus provide for disengagable automatic tamping and/or cinching of the sealing plug when the apparatus is withdrawn from the puncture site. The disengagable automatic tamping and/or cinching is facilitated by transducing a motive force generated by the withdrawal of the apparatus into a tamping and/or cinching force.01-28-2010
20110218567Systems and Methods for Treating Septal Defects - A system for treating a septal defect having an implantable treatment apparatus and devices for delivering the implantable treatment apparatus and methods for treating a septal defect are provided. The implantable treatment apparatus is preferably implantable through a septal wall or portion thereof. The treatment system can include a flexible elongate body member, a delivery device configured to deliver the implantable apparatus, a stabilization device configured to stabilize the body member and a positioning device configured to position the delivery device in a desired location.09-08-2011
20100016887PUNCTURE SEALS FOR CLOSING HOLLOW ORGANS HAVING A PUNCTURE OPENING - A puncture seal that seals a hollow organ having a puncture opening in a wall includes an inner bearing element that bears on an intraluminal side of the wall of the hollow organ, and a connection element connected to the inner bearing element and which, when the seal is fitted on the wall, protrudes through the puncture opening, wherein the inner bearing element has a surface area greater than the puncture opening, the inner bearing element is a continuous strip extending in an arc shape and strip sections lie substantially flat alongside one another in a fitted state, and the strip sections have a width that is smaller than the greatest length of the puncture opening, and the inner bearing element along the strip can be inserted into the hollow organ through the puncture opening and substantially parallel to the wall of the hollow organ.01-21-2010
20100016885Device to close openings in body tissue - Embodiments of the invention include a device for closing an opening in body tissue. The device may include a first end section and a second end section both including one or more anchoring members. Both end sections may be configured to transform in shape from a constrained configuration to an unconstrained configuration. The device may also include a midsection coupled between the end sections. The midsection may have at least one configuration that substantially prevents the flow of fluid therethrough.01-21-2010
20080287986Closure device - The present invention is for an arterial closure device which can be used to implement and augment the closure of a femoral artery or other related, adjacent or similar members of the vasculature and to reduce compression times associated therewith. A resorbable tubular plug is introduced through a delivery sheath subsequent to a procedure in which the delivery sheath is first utilized. The resorbable tubular plug is inserted through the delivery sheath and the distal tip of the resorbable tubular plug is positioned a short distance into the artery, whereby a suitable entry can be indicated by blood flow through and from the resorbable tubular plug. The delivery sheath is withdrawn to expose the resorbable tubular plug to the tissue track and to the arteriotomy and manual compression is applied to the wound site to foster and promote hemostasis.11-20-2008
20110152923INCISION CLOSURE DEVICE - A surgical instrument which can be inserted into an incision in a patient's stomach, wherein tissue-engaging members positioned within a lumen can be deployed therefrom and can engage the stomach wall surrounding the incision. Once engaged with the stomach wall, the tissue-engaging members can be retracted back into the instrument in order to pull at least a portion of the stomach wall into the instrument. In various embodiments, a cinching member can be utilized to cinch the stomach wall tissue and, as a result, seal the incision. The cinching member can comprise a loop and a pull member, wherein the loop can be disposed around a distal end of the surgical instrument such that it can be slid off of the distal end and around the tissue. The pull member can then be pulled proximally in order to decrease the size of the loop and cinch the tissue.06-23-2011
20110307006VASCULAR ACCESS CLOSURE DEVICES AND METHODS - Devices and related methods are disclosed that generally involve closing of an arteriotomy using a vascular access closure device that is deployed within the artery and closes the arteriotomy or arterial wound from the inside. The device can be biodegradable and/or self-expandable, and can optionally be formed of a shape memory polymer or a shape memory skeleton having a blood impermeable skin disposed therearound.12-15-2011
20100137903BIOADHESIVE CONSTRUCTS - The invention describes substrates, such as prosthetics, films, nonwovens, meshes, etc. that are treated with a bioadhesive. The bioadhesive includes polymeric substances that have phenyl moieties with at least two hydroxyl groups. The bioadhesive constructs can be used to treat and repair, for example, hernias and damaged tendons.06-03-2010
20100280546BIOMATERIALS FOR TRACK AND PUNCTURE CLOSURE - Embodiments include coatings for adherence of biomaterials to a tissue. Systems and methods for adapting such coated materials to vascular access closure are further proved.11-04-2010
20120041480Systems and Methods for Treating Septal Defects - A system for treating a septal defect having an implantable treatment apparatus and devices for delivering the implantable treatment apparatus and methods for treating a septal defect are provided. The implantable treatment apparatus is preferably implantable through a septal wall or portion thereof. The treatment system can include a flexible elongate body member, a delivery device configured to deliver the implantable apparatus, a stabilization device configured to stabilize the body member and a positioning device configured to position the delivery device in a desired location.02-16-2012
20120041479Tissue Sealant Compositions, Vascular Closure Devices, and Uses Thereof - The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.02-16-2012
20120310277APPARATUS FOR SEALING A VASCULAR PUNCTURE - An apparatus for sealing a puncture through a vessel wall including an elongate tubular body, a balloon carried by the body, an outer tubular member carried over the tubular body, and a sealant carried by the tubular body adjacent the balloon. Retracting the outer tubular member exposes the sealant.12-06-2012
20120310276METHODS FOR SEALING A VASCULAR PUNCTURE - A method for sealing a puncture through a vessel wall using a sealing device including an elongate tubular body, a balloon carried by the body, an outer tubular member carried over the elongate tubular body, and a sealant carried by the elongate tubular body adjacent the balloon. Retracting the outer tubular member exposes the sealant.12-06-2012
20120310275SINGLE PIECE, DUAL COMPONENT SEALING PAD AND METHODS - A tissue puncture closure device includes a carrier tube and a sealing plug. The carrier tube includes a distal end configured for insertion into the tissue puncture. The sealing plug is positioned in the carrier tube and arranged for ejection from the distal end of the carrier tube into the tissue puncture. The sealing plug includes a first collagen portion having a first cross-linked chemical structure, and a second collagen portion positioned proximal of the first collagen portion in the carrier tube. The second collagen portion has a second cross-linked chemical structure that is different from the first cross-linked chemical structure.12-06-2012
20120310274METHOD OF PERFORMING MULTIPLE ORAL AND NASAL SURGICAL PROCEDURES - The method of performing multiple oral and nasal surgical procedures may be applied to various different but related medical procedures, but is particularly well adapted for the performance of multiple operations for correcting various ear, nose, and throat conditions that cause obstructive sleep apnea (OSA) in the patient. The method allows the surgeon to perform multiple operating procedures in the nose, mouth, and/or throat in a single operating session, due to the use of hemostatic sheet and gel treatments in lieu of suturing and post-operative nasal hemostatic packs that preclude nasal breathing. A tracheal breathing tube is placed in the patient during the operation, leaving the surgeon free to perform multiple operations in the nose, mouth, and/or throat with hemostatic packs being placed immediately following each specific operating procedure. The packs are removed at the end of the operations before removal of the tracheal tube.12-06-2012
20120046689Wound Closure Material Applicator - A wound closure material applicator is provided which includes a handle assembly having a movable handle, a body portion extending distally from the handle assembly and a tip assembly supported adjacent the distal end of the body portion. The tip assembly includes a housing defining a bore, a tip member and a seal member. The tip assembly housing defines an inlet channel and a valve seat positioned adjacent the outlet of the inlet channel. The seal member is movable distally within the housing bore from a closed position in which the valve member abuts the valve seat to an open position in which the valve member is spaced from the valve seat. The tip assembly is configured such that movement of the seal member from the open to the closed position causes a reduction of pressure within a discharge channel of the tip assembly to minimize drippage of wound closure material from the applicator.02-23-2012
20110087275CONNECTIVE TISSUE CLOSURE DEVICE AND METHOD - A device for closing wounds such as openings in blood vessels as well as a method of doing so are disclosed. The device employs a fabric wrapped around an expandable frame both of which are inserted into a blood vessel through an introducer sheath. Once inserted, the expandable frame expands thereby expanding the fabric therewith. The fabric is made from a bioabsorbable material and includes a plurality of microhooks extending therefrom. One suitable material is polylactic acid fiber. Upon retraction of the device, the microhooks engage the adventitia surrounding the blood vessel causing the fabric to remain in position sealing the opening even after the expandable member is retracted and removed as well as the introducer sheath As the fabric is made from a bioabsorbable material, the device can remain in place even after hemostasis is reached and eventually dissolve within the body.04-14-2011
20100016886HIGH SWELL, LONG-LIVED HYDROGEL SEALANT - A high swell, long-lived hydrogel sealant formed by reacting a highly oxidized polysaccharide containing aldehyde groups with a multi-arm amine is described. The hydrogel sealant may be particularly suitable for applications requiring high swell and slow degradation, for example, tissue augmentation, both cosmetic and reconstructive; void filling; tissue bulking, for example treatment of urinary incontinence and acid reflux; and embolization. The high swell, long-lived hydrogel sealant may also be useful as a tissue sealant and adhesive, and as an anti-adhesion barrier.01-21-2010
20120046690SELF-ADJUSTING MEDICAL DEVICE - A device for sealing a fistula includes a first flange for orienting against a first wall of the fistula, a second flange for orienting against a second wall of the fistula, and at least one stem coupling the first and second flanges. Illustratively, the at least one stem is elastomeric. The stem(s) exhibit(s) an elongation of greater than about 0.6 mm/N of force applied between the first and second flanges in the range of elongation of about 0 mm to about 15 mm. Additionally or alternatively illustratively, the stem(s) comprise(s) (an) elastomeric tube(s) including (a) wall section(s) having a varying radius along its (their) length(s). Additionally or alternatively illustratively, the stem(s) pass(es) through (respective) opening(s) provided in at least one of the first and second flanges to permit adjustment of the location of at least one of the first and second flanges along the length of the stem(s).02-23-2012
20120046688Clip-Based Systems and Methods for Treating Septal Defects - Systems and methods for treating internal tissue defects, such as septal defects, with clip-based devices are provided. An exemplary clip-based device includes a tubular body having at least a first and a second deflectable member coupled thereto. The first and second members are coupled on opposite ends of the tubular body and configured to deflect between an undeployed configuration and a deployed configuration. In the deployed configuration, each member extends outwardly away from the tubular body in a position configured to abut a tissue surface. The first and second members are preferably configured to maintain a tissue wall therebetween and at least partially close any opening in the tissue wall.02-23-2012
20120232582VASCULAR CLOSURE PLUG WITH PROXIMAL CAP AND METHODS OF USE - The disclosure pertains to a vascular closure plug having a reinforced proximal end and methods of use therefor. The reinforcement may comprise a proximal force distributing member and a plurality of plug restraining members thereby tending to limit tearing or spreading of at least the proximal end of the vascular closure plug. In some embodiments, the reinforcement may also comprise a distal force distributing member and a plurality of plug restraining members, a circumferential collar, and/or a supplemental force distributing member.09-13-2012
20120209322TACKING DEVICE - The present embodiments provide apparatus and methods suitable for coupling a graft member to tissue, closing a bodily opening, and the like. At least one proximal deployable member and at least one distal deployable member are provided, each having a contracted state suitable for delivery and further comprising an expanded state. In the expanded state, the proximal and distal deployable members are configured to secure the graft member to the tissue. Optionally, a loop member may be provided for receiving a suture for further securing the graft member to the tissue.08-16-2012
20120209319REINFORCED SURGICAL ADHESIVES AND SEALANTS AND THEIR IN-SITU APPLICATION - In situ application of reinforced adhesive: applying uncured and curable matter to a surface, applying biocompatible inert reinforcing agent comprising at least one curing agent to the uncured composition; allowing curing within subject, cured composition together with the added reinforcing agent being configured to have improved mechanical support and strength.08-16-2012
20120209318NATURAL ORIFICE TRANSLUMINAL ENDOSCOPIC DEVICES FOR CLOSURE OF LUMINAL PERFORATIONS AND ASSOCIATED METHODS - Devices include at least two spaced apart flexible legs formed of a shape memory material, each leg having a respective free end configured to engage local tissue. The devices can also include at least one resilient member having opposing end portions, a respective end portion being attached to each leg at a location away from the free end. The resilient member is configured to take on a stretched configuration inside an endoscope during delivery. Alternatively or additionally, the devices include a cinch that is configured to snugly hold portions of both legs to force the legs closer together.08-16-2012
20120209317VESSEL CLOSURE SYSTEM - A power driven vessel closure device is configured for closing a hole in a wall of a body lumen. The vessel closure device can include a power operated drive system and a closure element delivery system. The closure element delivery system can be removably, operably, couplable with the power operated drive system. That is, the closure element system can be directly or indirectly attached to and removed from the power operated drive system, or components thereof. The operation of the power operated drive system can operate the closure element delivery system so as to move the closure element within the vessel closure device and deploy the closure element to close the hole.08-16-2012
20090171388VASCULAR CLOSURE DEVICE - A biocompatible material may be configured into any number of implantable medical devices including a vascular closure device. The vascular closure device includes a fibrous structure formed from at least one randomly oriented fiber, the randomly oriented fiber comprising at least one polymer, and at least one agent, in therapeutic dosage, incorporated into at least one of the fibrous structure and the at least one randomly oriented fiber.07-02-2009
20120010654MEDICAL CLAMP - A medical clamp includes a lower arm assembly, an upper arm assembly, and a belt. The upper arm assembly is pivotally connected to the lower arm assembly. The lower arm assembly and the upper arm assembly are configured for clamping relative to one another. The belt is connected to the lower arm assembly and the upper arm assembly and is configured for forming a loop therebetween.01-12-2012
20120010653Soft Tissue Repair System - A soft tissue repair system is provided for covering or filling openings in the annulus of an intervertebral disc. The soft tissue repair system uses a single plug or a combination of a first plug and a second plug. The second plug is a flowable plug such as an adhesive material or a material that hardens to a flexible plug material. Each plug is configured to close the opening in the annulus and can be positioned within the opening, over the opening at the exterior surface or over the opening at the interior surface. The plug can also be combined with a clamping mechanism that engages the annulus to secure the plug in the opening.01-12-2012
20110166595METHOD AND SYSTEM FOR SEALING PERCUTANEOUS PUNCTURES - A puncture closure device operable to seal closed a vessel puncture in a vessel. The puncture closure device includes a delivery member insertable through a tissue tract to the vessel puncture, a sealing material, and an expandable member. The sealing material is deliverable through the delivery member to the vessel puncture and configured to seal closed the vessel puncture from outside the vessel. The expandable member is positionable within the vessel through a vessel access distinct from the vessel puncture and is operable to temporarily seal closed the vessel puncture from within the vessel to restrict passage of the sealing material into the vessel.07-07-2011
20120065670DEVICE FOR SEALING AN INCISION - The present invention provides a plug device or grommet (03-15-2012
20120059410WOUND CLOSURE DEVICE AND METHOD - A method and apparatus for closing a vascular wound includes an apparatus that can be threaded over a guidewire into place at or adjacent the wound. The apparatus includes a chamber that encloses a hemostatic material therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.03-08-2012
20120016412ENTERIC FISTULA TREATMENT DEVICES - Disclosed herein is an implantable fistula closure device. The device may include an expandable longitudinally segmented body including a proximal end and a distal end. The segmented body may further include a plurality of porous bodies and a connecting member operably joining together the plurality of porous bodies. The plurality of porous bodies includes a first porous body with a proximal end and a distal end and a second porous body with a proximal end and a distal end, and the connecting member operably connects the proximal end of the first porous body with the distal end of the second porous body.01-19-2012
20120016410BIOPSY INCISION CLOSURE DEVICE - A biopsy incision closure device comprises a base having a frame incorporated therein. Together, the base and frame define an opening for performing a biopsy incision when the device is placed over a tissue surface. The base is typically composed of an elastomeric material and the frame comprises resilient inelastic members which can be used to close the opening in a highly uniform manner with minimum distortion and stress introduced into the tissue edges being drawn together.01-19-2012
20120016411Apical Closure System - Aspects of the present invention provide apparatuses and methods for closing an apical hole in a heart of a subject, including a hole-closure device that includes a tissue-attachment portion configured to attach to cardiac tissue around the apical hole, and a collapsible portion coupled to the tissue-attachment portion and configured to close the hole by collapsing inwardly inside the apical hole.01-19-2012
20120116447DEVICES AND METHODS USEFUL FOR SEALING BODILY OPENINGS - Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.05-10-2012
20120022586TISSUE CLOSURE DEVICE AND METHOD - A device having a plurality of anchors configured to be driven into a tissue, and a closure element extending between the anchors and configured to urge the anchors from a first configuration in which the anchors are a first distance from each other, toward a second configuration in which the anchors are a second distance from each other, the second distance being less than the first distance, wherein the device is configured to maintain the anchors in the first configuration during a surgical intervention and to subsequently allow the anchors to be moved by the closure element toward the second configuration.01-26-2012
20120059411DEVICE AND METHOD FOR TREATMENT OF INCISION OR HERNIA - Devices and methods for treating an abdominal incision or hernia are described. An implant for the restoration or prophylactic treatment of an abdominal wall comprises an elongate element and at least one sheet connected to the elongate element along a longitudinal axis of the elongate element. The elongate element is positioned along the line of incision, and the at least one sheet is secured to the abdominal muscles surrounding the incision.03-08-2012
20110093008DEVICE TO BE IMPLANTED IN A HUMAN OR ANIMAL BODY FOR MATERIAL OR SIGNAL DELIVERY OR ACQUISITION WITHIN THE BODY, AND METHOD OF IMPLANTING THE DEVICE - For fixedly implanting a device for material or signal delivery or acquisition or a part of such a device in a human or animal body, an opening is provided in hard tissue of the body, the opening reaching through a hard tissue layer, e.g. through a cortical bone layer into cancellous bone underneath. The device includes a plug portion (P) and/or a cover portion (C) which includes a ring of a material having thermoplastic properties extending around the plug portion (P) or on a tissue facing surface of the cover portion (C). The opening provided in the hard tissue has a cross section at least in the area of its mouth that is adapted to the plug or cover portion such that the plug portion (P) can be introduced through the mouth of the opening or the cover portion (C) can be positioned over the mouth of the opening such that the ring extends around the opening, along its wall and/or on the hard tissue surface around its mouth.04-21-2011
20110093006BIOCOMPATIBLE PHASE INVERTIBLE PROTEINACEOUS COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME - Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. The subject phase invertible compositions are prepared by combining a crosslinker and a proteinaceous substrate. The proteinaceous substrate includes one or more proteins and a polyamine, where the polyamine and a proteinaceous substrate are present in synergistic viscosity enhancing amounts, and may also include one or more of: a carbohydrate, a tackifying agent, a plasticizer, or other modification agent. In certain embodiments, the crosslinker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.04-21-2011
20120065668SYSTEM AND METHOD FOR VESSEL ACCESS CLOSURE - Embodiments are described for closing vascular access ports, such as arteriotomies, which involve placement and deployment of an expandable device configured to prevent blood flow across a subject arteriotomy while also keeping disturbance of intravascular flow to a minimum. Suitable prostheses may comprise one or more frames constructed from lengths of flexible materials, such as shape memory alloys or polymers. Such frames may be coupled to sheetlike or tube-like structures configured to spread loads, minimize thrombosis which may be related to intravascular flow, and maintain hemostasis.03-15-2012
20120065672Adhesive Laminates for Rapid Wound Occlusion - Provided herein are protective laminate devices comprising a biocompatible non-adherent substance and a fast-setting adhesive and methods of use. Also provided is a dispenser for an adhesive tape. The protective laminate devices and methods may be used for wound closure.03-15-2012
20120065671PLUG WITH COLLET AND APPARATUS AND METHODS FOR DELIVERING SUCH PLUGS - An apparatus for sealing a passage through tissue includes a plug including external threads, a lumen extending between its proximal and distal ends, and an annular collet slidably disposed within the lumen. The plug is carried on a distal end of a handle device that includes an inner member with a distal end that is slidable axially within the lumen of the body for moving the collet into a reduced cross-sectional region of the lumen, thereby compressing the collet to seal the lumen, and for deploying the plug from the handle device. During use, the plug is delivered into a passage through tissue over a guide wire. Once a desired location is reached, the plug is deployed from the handle device, thereby compressing the collet and sealing the lumen. The guide wire and handle device are removed, leaving the plug to seal the passage.03-15-2012
20120065669PINCH VASCULAR CLOSURE APPARATUS AND METHOD - A device for pinching an opening in a vessel wall, comprising an introducer sheath, a lumen having a distal opening and a bleed hole; an anchoring having a cylindrical shape in a first constrained state and a flared shape in a second unconstrained state; a pincher member slidably disposed between the anchoring member and the introducer sheath comprising at its distal end a plurality of elongate pincher arms, each of the plurality of elongate pincher arms having a free distal end such that when the pincher member distal end is unconstrained, the free distal ends of the elongate pincher arms are biased to expand radially; and an interior support member slidably disposed in the anchoring member comprising a plurality of elongate support legs, each having a free distal end such that when the distal end of the interior support member is unconstrained, the free distal ends curve outwardly.03-15-2012
20120158046APPARATUS AND METHOD FOR DRIVING A HEMORRHAGE OCCLUDER PIN INTO A HUMAN SACRUM - A method and apparatus to terminate sacral hemorrhaging in a patient having a sacrum and a pubic bone is disclosed. A C-shaped driver is positioned around the pubic bone of the patient and a hemorrhage occluder pin is driven into the sacrum of the patient by applying an impact force to a proximal end of the C-shaped driver. The driver may include a C-shaped shaft that defines a radius in the range 50 mm to 200 mm and a maximum span in the range 100 mm to 650 mm. The proximal end of the C-shaped shaft may have a blunt face with a breadth that is at least 2.5 times the diameter of the pin cap. A shaft distal end has a driver face facing away from an interior of the C-shape, and defining a driver face diameter that is preferably no less than 50% of the pin cap diameter.06-21-2012
20120065673SEPTAL DEFECT CLOSURE DEVICE - A device for closing a septal defect of a patient comprising a covering member and at least one retaining leg. The covering member has a first configuration for delivery and a second configuration for placement on the first side of the defect. The at least one retaining leg is configured to contact tissue on the second side of the defect to retain the covering member and has a first configuration for delivery and a second configuration for placement on the second side of the defect.03-15-2012
20120065667LEFT ATRIAL APPENDAGE OCCLUSION DEVICE - A left atrial appendage occlusion device including an occluder disk configured to substantially prevent blood from at least one of entering and exiting the left atrial appendage, a middle portion including a coiled element and a first anchoring element. The coiled element connects to the occluder disk, has a substantially constant cross section and allows for variable length, variable orientation, and/or varied angles. The first anchoring element connects to the coiled element and includes scalloped edges that are configured to anchor the occlusion device to inner walls of the left atrial appendage and reduce the risk of one of penetration and perforation of walls of the left atrial appendage. The left atrial appendage occlusion device may also include a self-centering element that connects to the occluder disk and middle portion and is configured to center the occlusion device within the orifice of the left atrial appendage.03-15-2012
20120209321APPARATUS AND METHODS FOR DELIVERING HEMOSTATIC MATERIALS FOR BLOOD VESSEL CLOSURE - Apparatus for sealing a vascular wall penetration disposed at the end of the tissue tract comprises a shaft, an occlusion element, a hemostatic implant, and a protective sleeve. The apparatus is deployed through the tissue tract with the occlusion element temporarily occluding the vascular wall penetration and inhibiting backbleeding therethrough. The hemostatic implant, which will typically be a biodegradable polymer such as collagen carrying an anti-proliferative agent or coagulation promoter, will then be deployed from the sealing apparatus and left in place to enhance closure of the vascular wall penetration with minimum scarring. The implant may be radiopaque to allow observation before release.08-16-2012
20120158047BODILY SEALANTS AND METHODS AND APPARATUS FOR IMAGE-GUIDED DELIVERY OF SAME - Generally, systems, methods, and apparatus related to the use of a dynamic imaging modality in an image guided intervention are disclosed herein. More specifically, the use of such modalities in sealing a bodily opening, such as those that may be formed during an invasive medical procedure are disclosed herein. In some embodiments, a method includes viewing a representation of an instrument within a body of a patient, adjusting a position of the instrument based on the viewing such that a portion of the instrument is at a location within the body of the patient, and delivering a sealant via the instrument to the location within the body of the patient. The sealant is configured to seal an opening in the body part.06-21-2012
20120158045VASCULAR CLOSURE DEVICE WITH AUTOMATIC SUTURE CUTTER - A tissue puncture closure device that includes an anchor (06-21-2012
20120109188Wound Closure Device Including Barbed Pins - A wound closure device includes an elongated body, a depth stop, and one or more barbs. The elongated body has first and second ends. The ends are configured and dimensioned for insertion within tissue on opposed sides of a wound. The depth stop is positioned on the elongated body to limit the insertion depth of at least a portion of the elongated body within tissue. The one or more barbs extend radially from the elongated body and define an inner surface. The inner surface includes a first portion, a second portion, and a third portion. The first portion is disposed at a first orientation relative to a longitudinal axis of the elongated body. The second portion is disposed at a second orientation relative to the longitudinal axis. The third portion disposed at a third orientation relative to the longitudinal axis.05-03-2012
20120071919VASCULAR SEALING DEVICE WITH HIGH SURFACE AREA SEALING PLUG - An internal tissue puncture closure method and apparatus. The method and apparatus provide a folded sealing plug that provides more surface area than conventional plugs to more fully cover and seal an external situs of an internal tissue puncture. The folded sealing plug may have a weave pattern that tends to cause the sealing plug to corkscrew into the internal tissue puncture as it is compressed toward an anchor placed inside of the tissue puncture.03-22-2012
20120071918Heart Occlusion Devices - The disclosure is directed to a heart occlusion device and a method for occluding an aperture defect in a heart. The heart occlusion device includes two separate wires 03-22-2012
20120109192CLOSURE DEVICE AND METHOD FOR SEALING A PUNCTURE IN A BLOOD VESSEL - A closure device for sealing a percutaneous puncture in the wall of a blood vessel includes: an insertion tool having an actuator which is operable in a first mode in which the actuator is configured for deployment of an inner seal inside the vessel and operable in a second mode in which the actuator is configured for tamping a locking member on an outside of the vessel, where the actuator is arranged to be set into the second mode in response to a pulling force acting on a filament connecting the inner seal and the locking member.05-03-2012
20120158044TISSUE PUNCTURE CLOSURE DEVICE - The present disclosure relates generally to methods and devices for closing and/or sealing an opening in a vessel wall and/or an adjacent tissue tract. In one illustrative embodiment, a device is provided for delivering and deploying an anchor, plug, suture, and/or locking element adjacent to the opening in the vessel wall and/or tissue tract.06-21-2012
20110087273Wound Closure Device - Biocompatible wound closure devices including an elongate body and a plug member are useful for wound repair.04-14-2011
20110066180Heart septal defect occlusion device - An occlusion device has a right disc made from a metal mesh having a plurality of openings, and a left disc having at least two skeletons that are covered by a membrane. Each skeleton passes through openings of the metal mesh to interlock the right and left discs, and a coil is wrapped around each opposing end segment of the skeletons. The skeletons can have a looped section where the skeleton is twisted or looped to cross or overlap itself. In addition, each skeleton can be formed from a braided strand of a plurality of wires.03-17-2011
20110066181TISSUE PUNCTURE CLOSURE DEVICE - The present disclosure relates generally to methods and devices for closing and/or sealing an opening in a vessel wall and/or an adjacent tissue tract. In one illustrative embodiment, a device is provided for delivering and deploying an anchor, plug, filament, and locking element adjacent to the opening in the vessel wall and/or tissue tract.03-17-2011
20110106149SEPTAL OCCLUDER AND ASSOCIATED METHODS - Devices are provided for closing septal defects such as PFOs. The devices generally include a proximal anchor member, a distal anchor member, and a flexible center joint connecting the two anchor members.05-05-2011
20110106148CLOSURE SYSTEM AND METHODS OF USE - A closure system and methods of use are provided for use in sealing an opening in a body tissue, such as a vascular puncture site. A method of closing the opening in the body tissue can be performed with the closure system having a closure clip. The method can include positioning the closure clip in a first closure clip position adjacent to the opening in the body tissue such that a plurality of spikes of the closure clip are inserted into the tissue at a location outward from a central axis of the opening. Subsequently, the closure clip can be positioned in a second closure clip position such that the plurality of spikes are pulled inward toward the central axis of the opening so as to pull the tissue between the opening and each of the spikes together and close the opening.05-05-2011
20110106147Percutaneous puncture sealing system - A method of sealing percutaneous punctures in a patient's body that open into an internal body cavity using a sealing material such as a fibrin adhesive while preventing the sealing material from entering the body cavity. An apparatus for delivering the sealing material is also disclosed.05-05-2011
20120271348SELF CLOSING OCCULSION DEVICE WITH A TWIST - An occlusion device and a method for occluding an opening in a body tissue with the occlusion device are provided. The occlusion device comprises a middle portion, a distal portion, and a proximal portion. The middle portion may be formed of non-woven wires and twisted about the longitudinal axis. The distal portion and the proximal portion may be comprised of a shape memory material. The occlusion device may be shape set to establish a preset configuration, and thus may be deformable to fit in and occlude the opening in the body tissue.10-25-2012
20100094335SYSTEMS AND METHODS FOR SUPPORTING OR OCCLUDING A PHYSIOLOGICAL OPENING OR CAVITY - Implantable devices for placement at a cavity or opening such as an aneurysm are disclosed. The implantable devices, in a deployed condition, have a generally inverted U-shaped profile with a curved or angled framework support structure sized and configured for placement in proximity to tissue surrounding the opening and anchoring legs extending proximally from the framework structure sized and configured to contact the wall of a neighboring lumen at opposed locations. Occlusive and semi-occlusive membranes may be associated with the framework support structure and deployed over the opening to provide exclusion of the opening and flow diversion. Proximal anchoring segments providing additional lumen wall surface area contact for the implantable device following deployment may be incorporated.04-15-2010
20090131978DEFECT OCCLUDER RELEASE ASSEMBLY & METHOD - A release assembly is provided to aid the reversible and repositionable deployment of a defect occluder. The release assembly includes an occluder tether having a distal portion comprising at least one suture loop, and a snare structure having a distal portion comprising a snare element. The at least one suture loop is receivable through at least a portion of the defect occluder, and reversibly looped over an anchor element so as to permit reversible collapse the defect occluder for selective ingress and egress from a delivery catheter. The snare element is reversibly engageable with the anchor element so as to reversibly retain the at least one suture loop upon the anchor element, and thereby hold the defect occluder in a posture for reversible free-floating tethered deployment in a defect while being observable in a final position prior to release.05-21-2009
20100249828INFLATABLE DEVICE FOR ENTERIC FISTULA TREATEMENT - Disclosed herein is an implantable fistula closure device. The device may include an expandable longitudinally segmented body including a proximal end and a distal end. The segmented body may further include a plurality of porous bodies and a connecting member operably joining together the plurality of porous bodies. The plurality of porous bodies includes a first porous body with a proximal end and a distal end and a second porous body with a proximal end and a distal end, and the connecting member operably connects the proximal end of the first porous body with the distal end of the second porous body.09-30-2010
20130012987IMPLANTABLE BIODEGRADABLE WOUND CLOSURE DEVICE AND METHOD - An implantable biodegradable device consisting of an inner button attached to a cylindrical segment, and an outer button attached to a retainment feature. The cylindrical segment is threaded on one end, with a surface groove. The retainment feature consists of radial strips with bent ends. The diameter of the radial strips is slightly larger than the outer diameter of the cylinder. The bent ends fit into the groove. An insertion tool can attach to the threads in the cylinder and push the inner button through a wound, then, holding the inner button in place, push the outer button toward the inner button until the bent ends engage with the groove. The top of the threaded end of the cylindrical segment is adjacent to the back surface of the outer button when the bent ends of the retainment feature are engaged with the groove.01-10-2013
20100249829Compartmented Syringe - A syringe includes a first fluid conduit and a second fluid conduit. The first fluid conduit includes two chambers for accommodating two substances of a plurality of substances. The second fluid conduit is disposed adjacent the first fluid conduit and has a chamber for accommodating one substance of the plurality of substances. The syringe may include a third fluid conduit. Each substance is intermixable to form a discharge material upon advancement of a plunger operably associated with each fluid conduit. The discharge material is defined by the intermixed composition of predetermined volumes of the substances the fluid conduits. The discharge material may be a hydrogel. A connecting tip may be operably associated with each fluid conduit. A syringe may include an end cap disposed on the end of each of the fluid conduits. The end cap may have a venting feature for enabling gas venting while preventing discharge until desired.09-30-2010
20100249827INFLATABLE DEVICE FOR ENTERIC FISTULA TREATMENT - Disclosed herein is an implantable fistula closure device. The device may include an expandable longitudinally segmented body including a proximal end and a distal end. The segmented body may further include a plurality of porous bodies and a connecting member operably joining together the plurality of porous bodies. The plurality of porous bodies includes a first porous body with a proximal end and a distal end and a second porous body with a proximal end and a distal end, and the connecting member operably connects the proximal end of the first porous body with the distal end of the second porous body.09-30-2010
20100249830EXPANDABLE PLUGS AND RELATED DELIVERY APPARATUSES AND METHODS - The present invention provides, in certain aspects, devices and methods for plugging passageways and other open spaces in the body. In one embodiment, a plugging assembly comprises a first plug member and a second plug member, wherein the second plug member is configured to contact and move a portion of the first plug member in plugging a body passageway. These plug members may be formed with one or more of a variety of biocompatible materials including some that are naturally derived and some that are non-naturally derived. In another embodiment, such a plugging assembly is combined with a device that is suitable for delivering the assembly into a body passageway.09-30-2010
20120283773BARRIER DEVICE FOR OSTIUM OF LEFT ATRIAL APPENDAGE - A membrane applied to the ostium of an atrial appendage for blocking blood from entering the atrial appendage which can form blood clots therein is disclosed. The membrane also prevents blood clots in the atrial appendage from escaping therefrom and entering the blood stream which can result in a blocked blood vessel, leading to strokes and heart attacks. The membranes are percutaneously installed in patients experiencing atrial fibrillations and other heart conditions where thrombosis may form in the atrial appendages.11-08-2012
20100185233Occluding Device - An occluding device for closing a body passage comprises an occluding body (07-22-2010
20120316602Catching Mechanisms for Tubular Septal Occluder - A septal occluder, such as one made from a polymer tube, can have portions on either side of a patent foramen ovale (PFO) or other septal defect. The portions on either side can be held in place with a catching mechanism that can take one of many forms. The tube can be made of bioresorbable materials.12-13-2012
20100204728Extraluminal Sealant Applicator and Method - An apparatus for applying sealant to a target tissue of a surgical site is provided. The apparatus includes a handle, conduit and an end effector. The handle has means configured and adapted for operating the end effector and dispensing biological sealant to the surgical site via the end effector. The conduit stores and/or carries sealant towards the end effector. The end effector is configured to clamp around a body organ or tissue and apply and confine biological sealant in a substantially uniform manner thereto.08-12-2010
20120172929APPARATUS FOR CLOSURE OF A LUMEN AND METHODS OF USING THE SAME - A generally tubular endovascular prosthesis (07-05-2012
20120083832CLOSURE DEVICE AND METHODS AND SYSTEMS FOR USING SAME - Embodiments of the present disclosure are directed to apical closure systems, devices, and methods and systems for use thereof, for closing surgical openings or defects in the wall of the heart.04-05-2012
20120083831MECHANICAL METHOD AND APPARATUS FOR SEQUENTIAL TISSUE FASTENING - A mechanical system for rotatably, sequentially securing opposing sides of a tissue wound with a fastener. An applicator apparatus is capable of imparting rotatable motion to a falcate tissue penetrator that sequentially pierces and carries a fastener into a first side and a second side of the tissue wound. The first side and second side of tissue can be simultaneously captured and positioned with respect to a tissue definition member or alternatively, the first tissue side and second tissue side can be individually, sequentially captured and positioned relative to the tissue definition member. The applicator apparatus can comprise a single fastener for small tissue wounds or resections or alternatively, the applicator can comprise a plurality of staged fasteners for use in closing a larger wounds or wounds with increased tension.04-05-2012
20120083830APPARATUS AND METHODS FOR SEALING VASCULAR PUNCTURES - An apparatus for sealing a passage through tissue communicating with a blood vessel includes a bioabsorbable plug member coupled to the distal end of a carrier member. The plug member includes a lumen extending therethrough that communicates with a lumen extending through the carrier member. A sealing member is disposed in the plug member lumen for sealing the lumen. A guide member is slidable into the lumen such that edges of a groove extending between proximal and distal portions of the guide member engage a wall of the lumen to define a bleed back lumen. The guide member is inserted into the passage until the distal portion enters the vessel. The plug member is advanced over the guide member until the plug member enters the vessel, whereupon blood enters the bleed back lumen to identify the location of the vessel relative to the plug member.04-05-2012
20120083829SYSTEM AND METHOD FOR VESSEL ACCESS CLOSURE - Embodiments are described for closing vascular access ports, such as arteriotomies, which involve placement and deployment of an expandable device configured to prevent blood flow across a subject arteriotomy while also keeping disturbance of intravascular flow to a minimum. Suitable prostheses may comprise one or more frames constructed from lengths of flexible materials, such as shape memory alloys or polymers. Such frames may be coupled to sheetlike or tube-like structures configured to spread loads, minimize thrombosis which may be related to intravascular flow, and maintain hemostasis.04-05-2012
20120083828Apparatus and method for delivery of biological sealant - A device for delivery of biologic materials, comprising: a cartridge having at least two cylinder bores for fluids to be delivered, wherein each cylinder includes an exit port for a fluid, a plunger within each cylinder for pushing the fluids out of the cylinder, a housing adapted to receive the cartridge, wherein the housing or cartridge includes an adaptor to receive and lock a manifold that operably connects to the exit ports of the cartridge, at least two toothed rams, wherein each toothed ram is at least partially within a cylinder bore, a trigger connected to the housing, wherein the trigger includes a toothed drive rack, a toothed wheel assembly that cooperates with the toothed drive rack and with the toothed rams, as well as methods of making the device, methods of using the device to treat discs, kits including the device.04-05-2012
20120136386Heat-Generating Device, Heat-Generating Method and Biological Tissue-Bonding Device - The present invention provides: a heat-generating device which includes a heat-generating unit 05-31-2012
20100174312COMPRESSIBLE TISSUE ANCHOR ASSEMBLIES - Apparatus and methods for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.07-08-2010
20120172927LEFT ATRIAL APPENDAGE OCCLUSIVE DEVICES - An occlusive device for left atrial appendage occlusion that has a membrane component configured to inhibit passage of blood and an expandable frame formed from a plurality of wires having a cupped occlusive component at least partially covered with the membrane component, one or more anchors with looped ends and a hub component. The occlusive device can be delivered percutaneously. The occlusive device is useful in the occlusion of the left atrial appendage.07-05-2012
20120172928APPARATUS AND METHOD FOR SEALING A VESSEL PUNCTURE OPENING - A device for sealing a puncture opening may include a base frame having a delivery configuration, wherein the base frame is retracted to have a relatively smaller overall profile, and a deployed configuration, wherein the base frame is extended to have a relatively larger overall profile. The base frame is sized to engage an interior surface of the blood vessel wall in the deployed configuration. A sealing section is coupled to the base frame, the sealing section having an initial configuration, wherein the sealing section permits fluid flow, and a barrier configuration, wherein the sealing section prevents fluid flow. The sealing section in the barrier configuration is sized to block fluid flow through the puncture opening when the base frame is in the deployed configuration.07-05-2012
20120253387DEVICE SYSTEM AND METHOD FOR TISSUE ACCESS SITE CLOSURE - A system for closure of a vascular access site and a device for closure are provided. The system includes a radially expandable device sized and configured for positioning within a blood vessel and a delivery catheter. The catheter is designed for delivering the radially expandable device through the vascular access site and expanding the radially expandable device in a position that spans the vascular access site, thereby at least partially closing the vascular access site.10-04-2012
20100049246VOLUMETRIC GRAFTS FOR TREATMENT OF FISTULAE AND RELATED METHODS AND SYSTEMS - Described are devices, methods, and systems useful in the treatment of fistulae, and in certain embodiments those having openings extending into the alimentary canal, such as anorectal fistulae. Illustratively, an anorectal fistula can be treated by placing a volumetric construct within the primary opening of the fistula. In certain embodiments, the volumetric construct can include a rolled remodelable material processed to form a substantially unitary body. Advantageous such remodelable materials can include collagenous extracellular matrix materials, such as small intestine submucosa.02-25-2010
20100049245SHEATH-MOUNTED ARTERIAL PLUG DELIVERY DEVICE - A method of facilitating hemostasis of a blood vessel puncture. The method includes the steps of inserting a tubular device into a puncture in a blood vessel to establish access to the blood vessel, providing a vessel closure system around the tubular device, introducing a hemostatic material into a space between the tubular device and vessel closure system, and delivering the hemostatic material adjacent to the puncture to facilitate hemostasis of the puncture.02-25-2010
20100049244DOUBLE THREADED TISSUE TACK - There is disclosed a threaded tissue tack for use in approximating and securing a pair of tissue sections together. The threaded tissue tack has a central body portion and first and second screws extending from opposite ends of the central body portion. The first screw includes a left-hand thread and the second includes a right-hand thread. Engagement structure is provided on the central body portion to rotate the threaded tissue tack about its longitudinal axis and into the pair of tissue sections. There is also disclosed a tack driver for rotating the threaded tissue tack into the tissue. Guards are provided intermediate first and second ends of the central body portion and the first and second screws to protect surrounding tissue from the tack driver.02-25-2010
20100298867TISSUE CONNECTOR WITH TISSUE GRASPING PROTRUSIONS EQUALLY SPACED ABOUT THE PERIPHERY OF THE CONNECTOR AT SUCCESSIVE AXIAL LOCATIONS - A tissue connector has a first end, a second end, a body with a periphery and a plurality of tissue grasping protrusions extending from said periphery of said body. The plurality of protrusions are adapted to grasp tissue in one direction of movement of the connector through tissue and are not adapted to grasp tissue in an opposite direction of movement of the connector through tissue. At axial locations of said body, three of said protrusions are about equally located about the periphery of said body. At axial locations on a cylindrical periphery of the body, protrusions are located at about 120 degree spacings.11-25-2010
20100274281PLUG WITH DETACHABLE GUIDEWIRE ELEMENT AND METHODS FOR USE - An apparatus for sealing a passage through tissue includes a bioabsorbable, threaded plug carried by a delivery device. A guide wire is receivable through lumens in the plug and delivery device that includes wings on a bioabsorbable distal portion. With the wings collapsed, the guide wire is advanced through the passage into a blood vessel, the wings expanding once located within the vessel, and the guide wire is withdrawn until the wings contact the vessel wall. The plug is threaded into the passage over the guide wire until the plug is disposed adjacent the wings. The distal portion of the guide wire is secured to the plug, e.g., by compressing a collet within the plug lumen that seals the lumen, and is severed from a proximal portion thereof. Thus, the plug and distal portion are deployed with the plug sealing the passage.10-28-2010
20120221042Methods And Devices For Treating The Left Atrial Appendage - Methods and devices that treat the left atrial appendage by bringing the distal wall of the appendage to a position where the tissue of the wall blocks the ostium, thereby preventing blood from flowing into the appendage. The methods and devices are adapted to create a separation between the distal wall of the appendage and the adjacent pericardium such that the risk of rupturing the pericardium are minimized.08-30-2012
20120253385CLOSURE MEDICAL DEVICE AND DELIVERY MECHANISM - A delivery mechanism for deploying a closure device includes several slidable members, a plunger, and attachments to tension members of the closure device. Deployment of the closure device includes controlling placement and expansion of the device within tissue using the tension members, the plunger, and the slidable members.10-04-2012
20120221043SYSTEM AND METHOD FOR SEALING ACCESS - The present invention relates to an apparatus and a method for sealing a puncture in a tubular tissue structure or the wall of a body cavity. More specifically, the present invention is directed to an apparatus and method for sealing a puncture site in the wall of a tubular tissue structure, or in the wall of a body cavity with a stabilizer used to stabilize the material used to seal the puncture site as the material is positioned. The material is inserted into the puncture site as a ribbon or sheet on an introducer element such as a needle, a cannula, a guide wire, an introducer element adapted for dialysis, an introducer element adapted for catheterization, a trocar, or any other introducer element used to access the lumen of a tubular tissue structure or used to access a body cavity.08-30-2012
20120226309Device, Kit And Method For Closure Of A Body Lumen Puncture - A medical device and method for closure of a puncture in a body lumen are disclosed. The device has an aggregate (09-06-2012
20120226308SURGICAL CLOSURE SYSTEMS AND METHODS - A device for closing an opening in a tissue includes a closure body, a fastening element, and a capture strip coupleable to the closure body such that the capture strip is moveable from a first position to a second position relative to the closure body, the capture strip including a receptacle configured to receive the fastening element when the capture strip is in the first position such that movement of the capture strip from the first position to the second position causes the fastening element to urge the closure body toward the tissue.09-06-2012
20120232584Methods and Systems for Medializing a Turbinate - Methods and systems for medializing a turbinate. Exemplary embodiments comprise methods and systems for repositioning a turbinate proximal to a septum. Certain embodiments comprise an implant and a flexible member coupled to the implant. Embodiments may also comprise an insertion device to install the implant in a desired location.09-13-2012
20120232581Tamponade for Biopsy Surgery and Method of Operation - A device for a biopsy procedure using a probe is provided. The probe, such as a needle, has an inner bore. A tamponade device is provided having a stem portion and an expandable portion, the tamponade device is sized to fit within the probe inner bore. The expandable portion is changeable between a first size and a second size with the second size being larger than the first size. A sheath disposed about the expandable portion, the sheath sized to fit within the probe inner bore. The expandable portion applies direct pressure to a hemorrhage location when inflated to the second size.09-13-2012
20120232583VASCULAR HOLE CLOSURE DELIVERY DEVICE - A surgical delivery instrument for delivering a vascular hole closure device having a hole covering member. The delivery instrument comprises a housing, a plunger and an advancer movable within the housing, the advancer having a first portion and a distal portion hingedly connected to the first portion and forming a casing for supporting the hole covering member. Distal movement of the advancer pivots the casing from an angled position to a more linear position to change the orientation of the covering member from a transverse position to a more aligned position. The plunger is advanceable to advance the covering member into the vessel.09-13-2012
20120232585METHOD OF CLOSING AN OPENING IN A WALL OF THE HEART - Disclosed is a closure catheter, for closing a tissue opening such as an atrial septal defect, patent foreman ovale, or the left atrial appendage of the heart. The closure catheter carries a plurality of tissue anchors, which may be deployed into tissue surrounding the opening, and used to draw the opening closed. Methods are also disclosed.09-13-2012
20080300624Tissue Stabilizer and Fastener - A surgical instrument for applying a fastener to tissue of a patient. The instrument includes an elongate shaft having a working end and a grip end opposite the working end. The instrument includes opposing stationary jaws mounted on the working end of the elongate shaft defining a gap between the jaws. The gap is sized and shaped for receiving tissue. At least one of the jaws includes a fastener ejector directed toward the gap for introducing a fastener into tissue received in the gap to selectively fasten the tissue with the fastener. The instrument includes a mechanism operatively connected to the fastener ejector for introducing the fastener into the tissue thereby applying the fastener to the tissue of the patient.12-04-2008
20120265243Hemostatic Device And Its Methods Of Use - A hemostatic device is provided for sealing a puncture of a vessel. The hemostatic device includes a locator device and an injection tube coupled to the locator device. The locator device includes a device valve that is actuatable to selectively restrict access to a portion of the locator device. The hemostatic device is advanced into the vessel until a first fluid is channeled through the locator device. The device valve is actuated to selectively restrict the first fluid from being channeled through the locator device. A second fluid is injected through the injection tube to facilitate sealing a puncture of the vessel. The hemostatic device is withdrawn from the vessel.10-18-2012
20110029011Clotting method for the repair of vascular defects and malformations - A method of sealing damaged and defective vessels utilizes stable thrombin and non-thrombin based solutions, gels, and biological glues to coat the tips of surgical appliances, such as surgical wires and trocars, with concentrations sufficient to cause clotting. The surgical wire or other appliance, with clotting material at its tip, is positioned within a protective sheath, such as a catheter or needle. The sheath provides a barrier which prevents clotting material to insinuate itself into healthy tissue. In the preferred embodiment, the protective catheter containing the wire is then inserted into the body of the patient and directed to the damaged site. The wire is then partially extended out of the sheath to allow the clotting material to be applied and deposited onto the damaged vessel, thereafter the wire and sheath are safely withdrawn from the body of the patient.02-03-2011
20110046665Closure Device, Deployment Apparatus, and Method of Deploying a Closure Device - The present invention relates a closure device implant for sealing an opening formed through biological tissue including a plug, a rigid wire including a plastically deformable portion configurable between an unrestrained position and a restrained position relative to the plug, wherein a distal end of the wire is substantially spherically shaped, and a footplate attached to the wire, wherein the footplate comprises an elongated plate portion including a wire channel. The present invention also relates to a closure device deployment device including an elongated housing, a sheath assembly connected to the housing, and at least two sliding members slidably connected to the housing.02-24-2011
20110046664VASCULAR WOUND CLOSURE DEVICE AND METHOD - A method and apparatus for closing a vascular wound includes a guidewire and/or other surgical implement extending from the wound. A hemostatic material is advanced over the surgical implement and into contact with an area of the blood vessel surrounding the wound. The surgical implement is removed. Blood soaks the hemostatic material, and blood clotting is facilitated by the hemostatic agent within the material. A sealing layer of adhesive can be applied to the hemostatic material, confining the blood flow to the material. Thus, the vascular puncture wound is sealed by natural blood clot formation.02-24-2011
20110046663POLYMER MEMBRANE LOCATOR WITH BUILT-IN STRESS RELIEF STRUCTURE - A tissue puncture locator device that includes an expandable member, a deformable membrane, and an actuator. The expandable member is movable between an unexpanded position and an expanded position. The deformable membrane extends around at least a portion of the expandable member. The membrane has a stress relief portion. The actuator is operable to move the expandable member between the unexpanded and expanded positions.02-24-2011
20110046662Occlusion Device And Method For Its Manufacture - The present invention relates to an occlusion device (02-24-2011
20120323271FISTULA CLOSURE DEVICES AND METHODS - Described are methods and systems for treating fistulae and other passageways and openings in the body. In certain aspects, an anchored suture is provided that extends from at or near a first fistula opening and through a fistula tract toward a second fistula opening. Various modes of anchoring may be used in this regard including, in some modes, having the suture extend from a deployed anchoring member positioned in and/or around the first opening. The anchored suture, which has a more slender cross sectional dimension relative to the fistula tract through which it extends, is capable of receiving an optional fill substance therealong in the tract. A fill substance can be or include a variety of biodegradable and/or non-biodegradable objects and materials including flowable and non-flowable materials.12-20-2012
20120323270LEFT ATRIAL APPENDAGE OCCLUDER - Systems and methods for occluding a left atrial appendage are disclosed. A left atrial appendage may be covered with a first occluder device to obstruct the passage of blood out of the left atrial appendage. The first occluder device may include an expandable member, a cover attached to and covering an end of the expandable member, and a one-way valve disposed in the cover. The cover may form a flexible pocket between the cover and the expandable member. The cover may be made of bioprosthetic material. A second occluder device may also be disposed within the left atrial appendage by inserting the second occluder device through the one-way valve in the cover of the first occluder device. The second occluder device may be used to stretch the left atrial appendage to obliterate the left atrial appendage.12-20-2012
20120330352TRANSAPICAL CLOSURE DEVICES AND METHODS FOR USE - Apparatus and methods are provided for sealing a puncture through the wall of a patient's heart into a heart chamber, e.g., at the apex of the heart into the left ventricle. A positioning member is advanced into the puncture until a positioning element thereon is disposed within the chamber, the positioning element is expanded within the chamber, and the positioning member is withdrawn until the expanded positioning element contacts the endocardial wall of the chamber. A cartridge carrying a solid sealant is advanced over the positioning member, and the sealant is deployed within the puncture, e.g., offset proximally from the endocardial wall, the sealant expanding upon exposure to fluid within the puncture to seal the puncture.12-27-2012
20100234881PFO CLOSURE DEVICES AND RELATED METHODS OF USE - Devices and methods for sealing a passageway formed by a patent foramen ovale (PFO track) in the heart are provided. One method includes providing an abrading device to the PFO track and abrading the tissue within the PFO track. The abraded tissue forming the PFO track is then held together under pressure, either via lowering right atrial pressure or via applying suction to the septum primum to pull it into apposition against the septum secundum. After a sufficient period of time, the pressure is released and the abraded tissue heals to form a robust seal over the PFO track. Additionally, several devices are provided which can be placed into the PFO track to apply adhesive to the walls of the PFO track. The devices may or may not be left within the PFO track. If the devices are not left within the PFO track, the walls of the PFO track, covered with adhesive, are brought into apposition with one another and adhered together. If the device is left within the PFO track, the device is flattened from an expanded configuration to a flattened configuration, and the walls of the PFO track, adhering to the outer surface of the device, are pulled toward each other as the device flattens. The device may also include interior structure to hold the device in a flattened configuration.09-16-2010
20100234879Systems and Methods for Treating Septal Defects - A system for treating a septal defect having an implantable treatment apparatus and devices for delivering the implantable treatment apparatus and methods for treating a septal defect are provided. The implantable treatment apparatus is preferably implantable through a septal wall or portion thereof. The treatment system can include a flexible elongate body member, a delivery device configured to deliver the implantable apparatus, a stabilization device configured to stabilize the body member and a positioning device configured to position the delivery device in a desired location.09-16-2010
20100234878CLOSURE DEVICE WITH STRING RETRACTABLE UMBRELLA - A repositionable closure device for occluding a body opening is provided. The closure device includes distal and proximal occluding bodies having expandable distal and proximal umbrella frames. Each umbrella frame includes a plurality of struts connected to a biocompatible sheet material. The distal and proximal umbrella frames expand to expanded configurations on opposite sides of the body opening. The struts of the distal umbrella frame terminate with an eyelet. The distal occluding body is connected to a distal end of a center rod and the proximal umbrella frame is slidable along the center rod via a center ring. At least one drawstring is threaded through the eyelets and the center ring, connecting the distal and proximal occluding bodies. The drawstring extends proximally from the center ring. Manipulation of the drawstring and the center rod is configured to collapse the closure device for at least partial retrieval during repositioning.09-16-2010
20100234885PATENT FORAMEN OVALE CLOSURE SYSTEM - A patent foramen ovale closure device, method of delivering and a delivery system are provided. The device may include a closure device releasably connectable to an actuator. The device may include a proximal segment, an intermediate segment and a distal segment. When delivered, the proximal segment and intermediate segment form a first clip-shaped portion sized and configured to be positioned over a septum secundum of the patent foramen ovale, and the intermediate segment and distal segment form a second clip-shaped portion sized and configured to be positioned over a septum primum of the patent foramen ovale.09-16-2010
20100234884CLOSURE DEVICE WITH TEXTURED SURFACE - A closure device closes an opening in a body cavity. The closure device includes a closure member that has an external, tissue-engaging surface formed with tissue engaging surface irregularities. An elongate member is disconnectably connected to the closure member.09-16-2010
20100234883FLEXIBLE TAMPING DEVICE - A method and apparatus for sealing a puncture or incision formed percutaneously in tissue separating two internal portions of the body of a living being with an anchor, a sealing plug and a filament connecting the anchor and sealing plug. The method and apparatus provide for a tamping device that is coilable in some configurations and stiff and straight in other configurations. The coilable tamping device may also automatically tamp the sealing plug when the apparatus is withdrawn from the puncture site. The automatic uncoiling and tamping is facilitated by transducing a motive force generated by the withdrawal of the apparatus into a tamping force.09-16-2010
20120277792VASCULAR WOUND CLOSING APPARATUS AND METHOD - Wound closure apparatus is provided including a body having an elongated, lowermost force-transmitting surface operable to be placed in a proximal, external, wound-closing position on a patient, together with a force-exerting assembly coupled with the body and operable to exert a downwardly directed force serving to generate wound-closing pressure against the patient's tissue. The force-transmitting surface is preferably three-dimensionally asymmetric so that forces of different magnitude are exerted at different locations along the length of the surface. The apparatus is especially designed for the closure of wounds attendant to endovascular interventions, e.g., a femoral artery puncture wound incident to percutaneous cardiac intervention (PCI), and is capable of quickly effecting wound closure with a time-to-ambulation (TTA) of approximately 60 minutes, and with a very low complication rate.11-01-2012
20120089179LOCATOR AND CLOSURE DEVICE AND METHOD OF USE - The present invention is directed to a device which is capable of both locating a punctured blood vessel wall and sealing the puncture in the vessel and to the method of using the device as well. In one embodiment, the device includes an elongate deployment member having a sealing element releasably disposed within a distal end thereof, said deployment member being coupled to a first actuator configured to retract said deployment member relative to said sealing element, and an elongated indicator member having a proximal end and a distal end, said indicator member extending through a lumen in said deployment member such that the distal end of said indicator member extends distally of the distal end of the deployment member, and said indicator member being coupled to a second actuator configured to retract said indicator member relative to said deployment member.04-12-2012
20120089178Device and Method to Facilitate Safe, Adhesion-Free Surgical Closures - Surgical devices and methods are provided for preventing the formation of post-operative adhesions. In one device, an envelope of bioabsorbable material defines at least one opening, and a layer of bioabsorbable adhesion-preventing material is disposed on an exterior surface of the envelope. A rigid or semi-rigid barrier member is at least partially disposed in a space inside the envelope, without adhering to the envelope such that the barrier member can be pulled out of the envelope through the opening. In another device, a rigid or semi-rigid barrier member is removably attached to a layer of bioabsorbable adhesion-preventing material by a controlled adhesive. In another device, a rigid or semi-rigid bioabsorbable barrier member, such as compressed cellulose, is attached to a layer of bioabsorbable adhesion-preventing material. The envelope of bioabsorbable material may include cellulose or oxidized regenerated cellulose. The adhesion-preventing material may include chemically modified sodium hyaluronate and carboxymethylcellulose.04-12-2012
20120089177CAM DRIVEN COMPACTION TUBE FOR VASCULAR CLOSURE DEVICE - A method and apparatus for sealing a puncture or incision formed percutaneously in a tissue. The apparatus including an anchor, a sealing plug, a filament connected between the sealing plug and the anchor, a compaction member assembly, a spool and a driving plate. The compaction member assembly being disposed adjacent the sealing plug and structured and arranged to apply an axially directed compressive force to automatically compact the sealing plug toward the anchor. The spool has a portion of the filament wound thereon. The driving plate being connected to the spool and having a cam surface portion. The cam surface portion is arranged to contact a proximal end of the compaction member assembly upon rotation of the spool to advance a distal end of the compaction member assembly.04-12-2012
20110276087METHOD AND APPARATUS FOR SEALING ACCESS WITH AN ANTI-INFLAMMATORY INFUSED MEMBER - An apparatus and a method for sealing a puncture in a tubular tissue structure or the wall of a body cavity are provided. The apparatus and method include a bioabsorbable member that contains an anti-inflammatory agent.11-10-2011
20110276086Atrial Septal Occluder Device and Method - An atrial septal occluder device for repairing an atrial septal defect in a human heart includes an elongated catheter for insertion into and moved along a blood vessel and into the heart of a patient. The catheter includes a head portion, a tail portion and a neck portion between the head and tail portions. The neck portion is about 1 cm in length and 2 to 4 mm in diameter. The device also includes an Amplatzer ASO removably fixed to the head of the device and a moveable neck portion for positioning the ASO with respect to the ASD and an activator for closing the ASO over the ASD from outside of the patient's body.11-10-2011
20110319930DEVICE FOR MIXING AND DISPENSING OF TWO-COMPONENT REACTIVE SURGICAL SEALANT - An applicator for mixing and applying multi-component compositions to a work surface, such as two-component surgical sealants, while avoiding clogs, preventing cross-contamination of the components until a point of intended mixing at a location within the apparatus immediately upstream of an application opening in a tip cap, decreasing pressure drop along the applicator to facilitate fluid delivery, and increasing efficiency of mixing of the components. A luer hub sub-assembly having a proximal hub and a distal hub, an elongate, four-lumened cannula, and a spray tip sub-assembly are provided, with interconnections between the sub-assemblies preserving isolation of the fluid components from one another. The tip cap sub-assembly includes registration structure to assure proper alignment between tip cap and tip insert. The end wall of the tip cap includes a spinner region with three feeders leading thereto, the fluid components remaining isolated from one another in two of the feeders, and initiating mixing with one another in a third of the feeders.12-29-2011
20120101520VASCULAR PLUG HAVING COMPOSITE CONSTRUCTION - This invention relates to apparatus and methods used to seal a vascular puncture site, particularly sites of punctures that are the result of catheterization or other interventional procedures. The sealing device includes a sealing member and a tether. The sealing member occupies a space in an incision, puncture, or other wound and sealing the space that it occupies, to prevent further blood flow. The tether is attached to the sealing member, and provides the user with the ability to withdraw the sealing member if necessary. The sealing device further includes a restraining member associated with the sealing member. The restraining member provides the ability to more securely restrain the sealing member to prevent it from migrating from the deployment location within a tissue tract. The restraining member also provides an additional capability of manipulating the sealing member after deployment.04-26-2012
20120101519POROUS VASCULAR CLOSURE PLUG WITH STARCH POWDER - The disclosure provides a composite plug for vascular closure including a hemostatic material, and a method of manufacturing the composite plug including a hemostatic material. The composite plug may comprise one or more materials having varying porosity, density, or composition, and may include a powdered hemostatic material.04-26-2012
20120290001APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - An apparatus for sealing a puncture through tissue having an introducer sheath therein includes an elongate positioning member including a housing on a proximal end and an expandable member on a distal end, and a cartridge advanceable along the positioning member from a proximal position to a distal position. The cartridge includes a tubular member including a sealant and an advancer member disposed within lumen of the tubular member. A sleeve is slidably disposed over the tubular member distal end such that, when the tubular member is advanced over the positioning member, the tubular member distal end enters the introducer sheath while the sleeve is stopped and slides over the tubular member to expose the tubular member distal end within the introducer sheath. The introducer sheath and cartridge are then withdrawn, exposing the sealant within the puncture.11-15-2012
20100168789APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - An apparatus for sealing a puncture includes a cartridge, a pusher member, a sealant, and a tamping device on a proximal end of the cartridge. During use, the cartridge, sealant, and pusher member are advanced over a positioning member and into the puncture by advancing a cartridge hub carrying the tamping device. When further distal advancement of the cartridge is limited, the cartridge hub is further advanced, activating the tamping device, and causing the pusher member to advance relative to the sealant to compress the sealant within the puncture.07-01-2010
20100168790CURVED CLOSURE DEVICE - Devices and methods are disclosed herein for a closure device. A closure device includes a body movable from a pre-deployed configuration towards a deployed configuration, a plurality of tissue-engaging portions extending from the body. At least two of the tissue-engaging portions are separated by a first distance in the deployed configuration and a second distance in the pre-deployed configuration in which the first distance is smaller than the second distance. The closure device also includes a plurality of device capture features secured to the body. The device capture features are configured to move the tissue-engaging portions to a separation greater than the first distance.07-01-2010
20100168791SYSTEMS AND METHODS FOR CLOSING A HOLE IN CARDIAC TISSUE - Systems and methods for closing a hold in cardiac tissue. In at least one embodiment of a system for closing a hole in cardiac tissue, the system comprises an engagement catheter having a first and second lumen extending therethrough, an elongated wire capable of insertion into the second lumen of the engagement catheter, a plug capable of insertion into the second lumen of the engagement catheter; an elongated shaft capable of insertion into the second lumen of the engagement catheter, wherein the elongated wire is sized for slidable insertion through the lumen of the shaft and the hole of the plug.07-01-2010
20100131006SPLIT ENDS CLOSURE DEVICE - A device closes a patent foramen ovale (PFO), thus reducing or eliminating blood flow through the defect. The device is formed from a tubular structure having split ends, such that, after insertion, struts defined by the split ends pivot in a radial direction away from the tube, thereby securing the device within the septal defect.05-27-2010
20120150219METHOD AND APPARATUS FOR SEALING ACCESS - An apparatus and a method for sealing a puncture in a tubular tissue structure or the wall of a body cavity are provided. The apparatus and method include a bioabsorbable member that is partially external to and partially internal to an introducer sheath before and during placement thereof.06-14-2012
20120150218MEDICAL DEVICE FOR OCCLUDING A HEART DEFECT AND A METHOD OF MANUFACTURING THE SAME - An implantable device for occluding a septal defect has interleaved frame sections that allow flexibility to conform to a variety of defect geometries and provide reliable occlusion during endothelialization. Left and right frames connect to opposite ends of a floating connection post. The device is resiliently deformable and is biased into a natural state wherein, in situ in a variety of defect geometries, the device applies a sandwiching force to the tissue surrounding the defect that is relatively uniform across its diameter, improving stability and promoting occlusion.06-14-2012
20130018413Multimodality Left Atrial Appendage Occlusion Device - A left atrial appendage occlusion device is provided that acts in conjunction with a wireless transponder unit. The occlusion device provides a seal of the left atrial appendage opening, while the transponder is inserted into the left atrial appendage to sense one or more physiological conditions and relay the sensed information over wireless communication. Further, all or part of the left atrial appendage may be filled using a biocompatible inert filling material injected into the left atrial appendage as part of deployment of the transponder unit.01-17-2013
20130023926Catch Member for PFO Occluder - Delivery (and recovery) devices and techniques for delivering an implant into a desired location within the body and catch systems for such implants. The devices and techniques relate particularly to, but are not limited to, a patent foramen ovale (PFO) occluder made from a polymer tube. A catch system maintains an occluder in a deployed configuration by holding it in a reduced axial length position. Some embodiments have a compressible tip. Some embodiments have temporary catching mechanisms.01-24-2013
20100087851Methods and Compositions for Sealing and Adhering Biological Tissues and Medical Uses Thereof - Compositions and methods for sealing, coating and adhering tissues are provided that utilize a polymeric system comprising at least a Polymer and a crosslinking agent; and, optionally, (i) a Gelation Disrupting Agent, (ii) an Augmentative Polymer or Monomer, (iii) an Adjunct Compound (iv) an Antimicrobial Agent (v) an Adhesion Enhancer, (vi) a Crosslink Augmentating Agent or any combination thereof. Additionally, a Therapeutic Agent may be incorporated.04-08-2010
20080234726Low profile chest seal - A chest seal for treating an open pneumothorax that is low profile and thus unobtrusive so that the chest seal can be effectively maintained in position to seal a chest wound while allowing the pleural cavity to vent.09-25-2008
20080221615LOCATOR AND CLOSURE DEVICE AND METHOD OF USE - The present invention is directed to a method for sealing a puncture in a wall of a lumen of a body comprising the steps of deploying a deployment member of a sealing device through an elastic membrane adjacent the wall of the lumen and the puncture, wherein the sealing device includes a sealing element; positioning the sealing element adjacent the wall of the lumen; retracting the deployment member relative to the sealing element to stretch the membrane away from the wall of the lumen; retracting the deployment member relative to the sealing element to allow the elastic nature of the membrane to force the sealing element against the puncture; and retracting the device from the puncture.09-11-2008
20080221614Method for Closing an Arteriotomy - A method for closing an arteriotomy includes providing a guiding system and a closure system. The guiding system advanced through a sheath extending through the arteriotomy and into the blood vessel lumen. The guiding system includes a pair of stabilization wire guides, each guide including a retention foot disposed at a distal portion thereof. The retention feet are deployed within the lumen. With the entire sheath outside of the vessel, the closure device is then further advanced along the guiding system, or the sheath is pulled proximally over the closure device, thereby stretching or tearing a distal portion of the sheath. The closure system includes a closure device, such as a stapler including a staple that is actuated to close the arteriotomy. The retention feet are undeployed and the guiding system is removed from the body.09-11-2008
20130178896LIQUID APPLICATOR - The present invention provides a liquid applicator comprising: a hollow body portion incorporating a reservoir portion for containing a liquid to be applied by the applicator; an outlet portion having first and second ends, the first end being connected to an outlet mouth of the reservoir; an applicator tip assembly provided on the second end of the outlet portion for discharge of liquid from the reservoir portion via said outlet portion; a plug located in the mouth of the reservoir portion; and actuator means for applying an actuating force to the mouth wall to effect movement of the plug towards the outlet portion and for squeezing the walls of the reservoir portion to effect discharge of liquid from the reservoir portion via the outlet portion and the applicator device. The liquid to be dispensed is retained in a reservoir that is sealed by a plug until usage.07-11-2013
20120253386APICAL PUNCTURE ACCESS AND CLOSURE SYSTEM - A device, system, and method for providing access to, and sealing of, a body organ includes an implant device. An implant device has a main body having an internal access lumen, with a plurality of prongs extending from a distal end of the main body. The main body can include two lumens, one slidable within the other, to form a single continuous lumen with an adjustable length. The main body has an expanded configuration with an expanded diameter, and an unexpanded configuration with an unexpanded diameter. The prongs have a generally straight configuration where they extend distally of the distal end of the main body, and a bent configuration where the prongs bend around so that their tips extend proximally of the distal end of the main body. The device may include a hemostatic barrier to prevent fluid leakage therethrough when the main body is in the unexpanded configuration.10-04-2012
20110270303SYSTEMS AND METHODS OF TISSUE CLOSURE - Apparatus, systems, and methods are described for closing the base of a left atrial appendage or other tissue structure. A tissue closure device comprises a pair of legs having compliant surfaces for engaging against opposite sides of the tissue structure. A plurality of axially spaced-apart tissue-penetrating fasteners are delivered from one leg to the other to pierce the intervening tissue and hold the closure device in place on the tissue structure.11-03-2011
20110270302TISSUE PUNCTURE CLOSURE DEVICE WITH AUTOMATIC TORQUE SENSING TAMPING SYSTEM - Methods and apparatus for sealing a puncture or incision formed percutaneously in tissue separating two internal portions of the body of a living being with an anchor, a sealing plug and a filament connecting the anchor and sealing plug are disclosed. The methods and apparatus provide for automatic tamping of the sealing plug. In addition, torque required to tamp the sealing plug is automatically sensed and gear ratios of an automatic tamping device are automatically changed in response to sensed changes in torque. A planetary transmission may be used to automatically change gear ratios in response to the changes in torque.11-03-2011
20130138148BIOCOMPATIBLE SURGICAL COMPOSITIONS - Biocompatible macromer compositions are provided including an isocyanate-functional polyalkylene oxide combined with at least one multi-functional isocyanate as a first component, and a multi-amino functional compound possessing multiple primary amines as a second component. The isocyanate-functional polyalkylene oxide has pendant polyalkylene oxide groups. The resulting biocompatible macromer composition can be employed as an adhesive or sealant for medical/surgical uses.05-30-2013
20130090684TRANS-CATHETER VENTRICULAR RECONSTRUCTION STRUCTURES, METHODS, AND SYSTEMS FOR TREATMENT OF CONGESTIVE HEART FAILURE AND OTHER CONDITIONS - Embodiments described herein include devices, systems, and methods for reducing the distance between two locations in tissue. In one embodiment, an anchor may reside within the right ventricle in engagement with the septum. A tension member may extend from that anchor through the septum and an exterior wall of the left ventricle to a second anchor disposed along a surface of the heart. Perforating the exterior wall and the septum from an epicardial approach can provide control over the reshaping of the ventricular chamber. Guiding deployment of the implant from along the epicardial access path and another access path into and through the right ventricle provides control over the movement of the anchor within the ventricle. The joined epicardial pathway and right atrial pathway allows the tension member to be advanced into the heart through the right atrium and pulled into engagement along the epicardial access path.04-11-2013
20130178895SURGICALLY CLOSING PERCUTANEOUSLY PUNCTURES - A closure device for sealing a percutaneous puncture in a wall of a body passageway, the closure device including at least one of a toggle configured to engage an interior surface of the body passageway or a plug configured to engage an exterior surface of the body passageway and a guide wire configured to extend from an outside of the body to inside the body passageway, wherein at least one of the toggle and the plug is associated with the guide wire.07-11-2013
20130103076CELLULOSE-CONTAINING MEDICAL DEVICE HAVING A MULTI-LAYER STRUCTURE PRODUCED WITHOUT ADHESIVE - Implants include a film layer containing cellulose secured to a surface of the porous layer that also contains cellulose, wherein the film layer is secured to the porous cellulose without the use of an adhesive.04-25-2013
20130123838CLOSURE DEVICES, RELATED DELIVERY METHODS AND TOOLS, AND RELATED METHODS OF USE - A device for sealing a patent foramen ovale (PFO) in the heart is provided. The device includes a left atrial anchor adapted to be placed in a left atrium of the heart, a right atrial anchor adapted to be placed in a right atrium of the heart, and an elongate member adapted to extend through the passageway and connect the left and right atrial anchors. The right atrial anchor preferably includes a plurality of arms and a cover attached to the arms. The left atrial anchor also includes a plurality of arms and preferably does not include a cover. Preferably, the elongate member has a first end of fixedly connected to the left atrial anchor and a portion, proximal to the first end, releasably connected to the right atrial anchor. Preferably, the elongate member is flexible.05-16-2013
20130131720APPLICATORS, DISPENSERS AND METHODS FOR DISPENSING AND APPLYING ADHESIVE MATERIAL - An applicator/dispenser assembly for dispensing and/or applying an adhesive material comprises: a first body portion and a second body portion, at least one of the first and second body portions being movable relative to the other of the first and second body portions; a cavity in at least one of the first and second body portions; and a piercing or breaking member arranged on one of the first and second body portions. Movement of one of the first and second body portions relative to the other of the first and second body portions moves the piercing or breaking member into the cavity. When a container of adhesive material is at least partially disposed within the cavity, movement of one of the first and second body portions relative to the other moves the piercing or breaking member to rupture the container for dispensing and/or applying the adhesive material.05-23-2013
20130144331INTRODUCER SHEATH - The invention provides an introducer sheath (06-06-2013
20130158595ENTERIC FISTULA TREATMENT DEVICES - Disclosed herein is a non-vascular fistula treatment system. The system may include a collapsible member, at least one tether, and a bioresorbable material. The collapsible member may be configured for positioning through a fistula tract and may comprise first and second disc members. The outer perimeter of the second disc member may be larger than the outer perimeter of the first disc member, and the first disc member may comprise a tether attachment structure. The at least one tether may be attached to the tether attachment structure. The bioresorbable material may be configured for placement in the fistula tract and may comprise a coupling structure configured to couple to the at least one tether. The second disc member may be configured to seal to a surface of a body lumen at a distal opening of the fistula tract and occlude the fistula tract at the distal opening.06-20-2013
20130158594FISTULA TREATMENT DEVICES AND METHODS - Disclosed herein are implantable fistula treatment devices and related methods. In some embodiments, an anorectal fistula treatment device may comprise a disc-shaped distal anchor comprising a concave side and a convex side, an outer edge region, an inner sealing region protruding from the concave side, and an attachment region configured for attachment to a connecting member. The inner sealing region may have a greater thickness than at least a portion of the attachment region and the outer edge region may be oriented at an acute angle to the inner sealing region. The distal anchor may have a tapered edge and the outer edge region and inner sealing region may be configured to form separate seals against tissue about a distal opening of an anorectal fistula.06-20-2013
20110213414VASCULAR HOLE CLOSURE DEVICE - A device for closing an aperture in a vessel wall, the aperture having an external opening in an external region of the vessel wall and an internal opening in an internal region of the vessel wall. The device includes a covering member positionable inside the vessel against the internal opening of the aperture and having a dimension to prevent egress of fluid through the aperture. First and second retainers are positionable external of the vessel and have a tip of a smaller transverse dimension and facing in a direction toward the covering member for advancement toward the covering member. A flexible connecting member operatively connects the covering member and the first retainer and moves the first retainer toward the covering member.09-01-2011
20100286727TISSUE PUNCTURE CLOSURE DEVICE WITH ACTUATABLE AUTOMATIC SPOOL DRIVEN COMPACTION SYSTEM - A tissue puncture closure device includes an anchor, a sealing plug, a suture coupled to the sealing plug, a compaction arrangement, and an automatic driving assembly. The automatic driving assembly includes first and second spool members and an actuation member. The first spool member is configured to coil a portion of the suture. The second spool member is configured to coil a portion of the compaction arrangement. The actuation member is coupled to the first and second spool members. Activation of the actuation member releases the first spool member for rotation to apply a tension force in the suture, and releases the second spool member for rotation to distally advance a portion of the compaction arrangement to compress the sealing plug.11-11-2010
20100286726Hemostasis Device and Method for Using the Same - A hemostasis device is disclosed. The hemostasis device includes a stem portion including a top end and a bottom end, a handle portion connected to the top end of the stem portion, and a base portion connected to the bottom end of the stem portion. A method for utilizing the hemostasis device is also disclosed.11-11-2010
20100286725Systems and Methods for Closing a Percutaneous Vascular Puncture - A system and method for closing a percutaneous vessel puncture at the conclusion of a vascular catheterization procedure includes placement of an intravascular closure device having a radially and axially expandable tubular membrane and a radially expandable anchor at the distal sad of the membrane. The closure device is placed, by a delivery catheter extending through the puncture site, with its anchor radially expanded in a location upstream of the puncture site to enable the force of a patient's blood flow to deploy the tubular membrane to a proximally extended configuration closing the puncture from within the vessel.11-11-2010
20130150883HEMOSTATIC DEVICE - A hemostatic device, method of making, and method of using for internal and external applications to wounds in the body of a patient to induce hemostasis at an anatomical site.06-13-2013
20130150884BALLOON INSERTION APPARATUS AND METHOD OF SEALING A TISSUE PUNCTURE - The present invention provides apparatus and methods of closing internal tissue punctures. The apparatus and method provide for an introducer sheath having at least one side port enabling aspiration of an internal tissue puncture site and injection of a sealant.06-13-2013
20100318121DEVICE AND METHOD FOR ATTACHING AN IMPLANT TO BIOLOGICAL TISSUE - This invention generally relates to devices and methods for repairing an aperture in biological tissue. In certain embodiments the invention provides as system for closing an aperture in a biological tissue including a handle, an elongate shaft connected to the handle, a deployment scaffold connected to the shaft, in which the scaffold is configured to releasably retain a surgical implant, and at least one adhesive dispensing system.12-16-2010
20100318120HEMOSTATIC MATERIAL AND DELIVERY DEVICE - A hemostatic material, production method, delivery method, and apparatus are disclosed. The hemostatic material includes a peptide that preferentially selects exposed endothelial cells for bonding. The peptide is conjugated with a hemostatic agent (e.g., chitosan) to produce a peptide conjugated hemostatic agent. The peptide conjugated hemostatic agent is suspended in a flowable delivery medium that delivers the material to the endothelial cells to stop or reduce bleeding. An apparatus for delivering the hemostatic material includes a conformable covering for sealing off and maintaining an internal pressure in an injury cavity, a delivery port for delivering hemostatic material into the cavity, and a check valve that opens when a predetermined pressure is reached. Methods for producing the hemostatic material and using the apparatus are also disclosed herein.12-16-2010
20120283772TISSUE CLOSURE AND TISSUE CLOSING DEVICE - A living body tissue closing device includes an elongated body element, a clip (living body tissue closure) for closing a wound hole which penetrates a living body tissue membrane, and a thread. The body element includes a sheath, and elongated feeding and deformation arrangement. The elongated feeding and deformation arrangement includes a covered tube, a pusher tube, a thread anchoring cap, a guide wire, and a stopper. The clip includes a seal portion for covering the wound hole and a peripheral portion of the wound hole from one side of the living body tissue membrane, a deformation portion deformable between a first form in which the deformation portion can pass through the wound hole and a second form in which the deformation portion cooperates with the seal portion to sandwich the living body tissue membrane therebetween, and a fastener portion for retaining the deformation portion in the second form.11-08-2012
20120283771Craniotomy Plugs - Described herein is a cranial plug for a burr hole or a cranial perforation made in a skull during brain surgery, the cranial plug being flexible and having a bottom portion and side walls extending upwards from the bottom portion, the bottom portion and the side walls formed in a concave or substantially concave shape, or alternatively, forming a concave or substantially concave shape when inserted into a burr hole or cranial perforation.11-08-2012
20120283770COMPRESSIBLE ARTERIOTOMY LOCATOR FOR VASCULAR CLOSURE DEVICES AND METHODS - A tissue puncture locator device includes a temporary anchor configured for placement through a vascular puncture into a vessel. The temporary anchor includes a column member that defines a lumen. The temporary anchor is movable between an uncompressed position and a compressed position, wherein in the compressed position a portion of the column member protrudes radially outward. The column member may include a reduced thickness portion, wherein the column member protrudes radially outward at the reduced thickness portion. The column member, when expanded radially outward within the vessel, is sized to limit retraction of the temporary anchor through the vascular puncture.11-08-2012
20110313452CLOSURE DEVICE AND METHODS FOR MAKING AND USING THEM - A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.12-22-2011
20110313451CLOSURE DEVICE WITH STRING RETRACTABLE UMBRELLA AND METHOD FOR CLOSING A BODY OPENING WITH THE SAME - A method for closing a body opening in a patient is disclosed. The method comprises positioning a delivery catheter within the body opening. The delivery catheter includes a closure device comprising a distal occluding body and a proximal occluding body. The closure device is collapsibly disposed within a distal end of the delivery catheter. The method further includes deploying the closure device from the delivery catheter about the body opening such that a distal frame of the distal occluding body expands to its expanded configuration at a distal end of the body opening and a proximal frame of the proximal occluding body expands to its expanded configuration at an opposing proximal end of the body opening.12-22-2011
20110313450HEMOSTATIC PATCH - The present disclosure relates to a surgical patch and methods of using the same. The surgical patch includes a body having a substrate, a longitudinal slit bisecting at least a portion of the body, and at least one additional slit extending from the longitudinal slit defining a retractable section. The surgical patch of the disclosure may be used, for example, to provide hemostasis at a site of anastomosis.12-22-2011
20130190810CLOSURE DEVICE - A device for closing an opening in a wall of a body lumen includes a closure element with a first flange and a second flange. Both the first flange and the second flange may have a delivery cross-sectional dimension and a deployed cross-sectional dimension. The device for closing an opening further includes a first coupler element disposed on the first flange and a second coupler element disposed on the second flange, the first and second coupler elements cooperating to couple the first flange to the second flange.07-25-2013
20130190811SINGLE DISC OCCLUSIONARY PATENT FORAMEN OVALE CLOSURE DEVICE - The present invention is a method and device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart, and related methods of using such closure devices for closing the passageway.07-25-2013
20130190808BIOADHESIVE DELIVERY CATHETER MANIFOLD WITH MIXING FIXTURE AND METHODS - A bioadhesive delivery catheter includes a manifold, a dual lumen tube, and a mixing member. The manifold includes a delivery device passage and an injection port. The tube is insertable into the delivery device passage and includes first and second lumens positioned side-by-side. The first lumen extends proximal of the second lumen within the delivery device passage, and the second lumen is in flow communication with the injection port. The mixing member is positioned between a proximal inlet of the injection port and the second lumen and is configured to help mix a bioadhesive material that is delivered through the injection port into the second lumen.07-25-2013
20120016409SYSTEMS AND METHODS FOR FACILITATING CLOSURE OF BODILY OPENINGS - The present embodiments provide a system for facilitating closure of a bodily opening. In one embodiment, the system comprises an anchor having a deployed state dimensioned for engaging tissue surrounding the opening, a first tether coupled to the anchor and extending proximally therefrom, and a graft member comprising a first bore disposed therein. The anchor may comprise a width that is larger than a width of the opening such that the anchor is disposed securely within or distal to the opening. The first tether is dimensioned to be disposed through the first bore in the graft member, such that the graft member is advanced distally over the first tether. The graft member then may be secured to the anchor. Various anchor designs are provided along with a supporting framework that may be coupled to the graft member.01-19-2012
20120022587Systems and Methods for Treating Septal Defects - A system for treating a septal defect having an implantable treatment apparatus and devices for delivering the implantable treatment apparatus and methods for treating a septal defect are provided. The implantable treatment apparatus is preferably implantable through a septal wall or portion thereof The treatment system can include a flexible elongate body member, a delivery device configured to deliver the implantable apparatus, a stabilization device configured to stabilize the body member and a positioning device configured to position the delivery device in a desired location.01-26-2012
20120022585VASCULAR CLOSURE DEVICE WITH BIODEGRADABLE ANCHOR - This disclosure pertains to controllably bioabsorbable devices, particularly anchors for vascular closure plugs and to methods of use thereof.01-26-2012
20120029558Methods and Kits for Treating Lacerations and Puncture Wounds Using Inverse Therosensitive Polymers - In certain embodiments, the present invention relates to methods and kits for treating wounds, comprising the step of introducing into said wound a composition comprising at least one optionally purified inverse thermosensitive polymer, wherein said at least one optionally purified inverse thermosensitive polymer forms a gel in said wound, thereby temporarily occluding said wound. In certain embodiments, the present invention relates to the aforementioned method wherein a wound to a blood vessel or a segment of the GI tract is occluded, thereby preventing exsanguination and/or septicemia. In other embodiments, the inventive methods and kits described herein may be used to ameliorate (e.g., fill) temporarily a defect in a biological lumen, thereby strengthening said defect, preventing rupture of, or maintaining, improving or optimizing fluid flow through said lumen.02-02-2012
20120029557METHOD AND APPARATUS FOR IMPEDING MIGRATION OF AN IMPLANTED OCCLUSIVE STRUCTURE - A method of treating a hollow anatomical structure of a patient comprises implanting a bioabsorbable fibrous body in a hollow anatomical structure. The body is secured in the hollow anatomical structure to limit migration of the body within the hollow anatomical structure.02-02-2012
20120029556SEALING DEVICE AND DELIVERY SYSTEM - The invention relates to a sealing device for repair of cardiac and vascular defects or tissue opening such as a patent foramen ovale (PFO) or shunt in the heart, the vascular system, etc. and particularly provides an occluder device and trans-catheter occluder delivery system. The sealing device would have improved conformity to heart anatomy and be easily deployed, repositioned, and retrieved at the opening site.02-02-2012
20120029555EXPANDABLE BIOABSORBABLE PLUG APPARATUS AND METHOD - An apparatus for occluding a venous or arterial puncture site is disclosed including a plug insertable within, or adjacent to, a puncture site in a wall of a body lumen. An insert is forced into an aperture within the plug to cause expansion thereof. The insert may be drawn into the aperture by applying tension to a line passing therethrough and secured to the insert. Barbs may secure to the plug to engage the wall of the body lumen or adjacent tissue tract. Elongate members passing through the wall of the plug may be forced outwardly into the wall of the body lumen or adjacent tissue as the insert is forced into the aperture.02-02-2012
20130197571MINIMALLY INVASIVE SURGICAL TECHNIQUES - Apparatus and methods are described including a trocar (08-01-2013
20130197570DEVICE FOR CLOSING LUMINAL CAVITY AND METHOD THEREFOR - A luminal cavity closing device can include a flexible shaft, a lid member, and a detachment mechanism. The flexible shaft extends in an axial direction. The lid member which is attached to a distal end of the shaft, can be rotated according to a torque transmitted from the shaft. Thus, a lock section can be thrust into a periphery of an opening of a luminal cavity formed in a living body lumen, to thereby lock the lid member to the periphery. The detachment mechanism can be configured to detachably attach the lid member to the shaft. The torque can be transmitted to the lid member, and the shaft can be detached from the lid member by the detachment mechanism while the lid member is locked to the periphery of the opening of the luminal cavity.08-01-2013
20130103077VASCULAR SEALING DEVICE WITH LOCKING HUB - An internal tissue puncture closure method and apparatus. The method and apparatus provide a locking device for compressing and holding an external component such as a collagen sponge at a puncture situs. The locking device facilitates compression of the external component in a first direction, but prevents or locks against retraction.04-25-2013
20120065666SEAL-LESS DEVICE FOR DISPENSING MICROLITER QUANTITIES OF A MATERIAL INTO A SITE - A seal-less, hand-held dispensing device includes a support platform having a pair of finger gripping surfaces; first and second hollow members on the platform; and a compatibly sized plunger disposed in each hollow member. Each hollow member has a largest inside dimension in the range from about 0.2 mm to about 0.3 mm and each plunger has a largest outside dimension that is sized for compatible receipt within a hollow member. The largest outside dimension of each compatibly sized plunger is from about eighty percent (80%) to about ninety-five percent (95%) of the largest inside dimension of a hollow member. An actuator having a thumb actuating surface thereon is operatively engagable with each plunger. When fully extended a predetermined maximum finger span is defined between the actuating surface and the gripping surfaces, the maximum finger span being not greater than about 150 mm.03-15-2012
20120078294Vascular Hole Closure Delivery Device - A surgical delivery instrument for delivering a vascular hole closure device having first and second flexible members and a first and second engagement members extending from the respective flexible member. The delivery instrument includes a housing having first and second longitudinally extending openings and first and second projecting surfaces, the first projecting surface extending into the first opening for engagement by the first engagement member and the second projecting surface extending into the second opening for engagement by the second engagement member. The first engagement member is held by the first projecting surface until a predetermined force is applied to the first engagement member during placement of the closure device at a target site.03-29-2012

Patent applications in class Sutureless closure

Patent applications in all subclasses Sutureless closure