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Sensor responsive to body condition

Subclass of:

604 - Surgery

604019000 - MEANS FOR INTRODUCING OR REMOVING MATERIAL FROM BODY FOR THERAPEUTIC PURPOSES (E.G., MEDICATING, IRRIGATING, ASPIRATING, ETC.)

604048000 - Treating material introduced into or removed from body orifice, or inserted or removed subcutaneously other than by diffusing through skin

604065000 - Material flow varying means controlled by condition responsive sensor

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DocumentTitleDate
20130030358METHOD AND DEVICE FOR IMPROVING GLYCEMIC CONTROL - Systems, devices and methods are presented in the subject disclosure for recommending an insulin dose adapted for use with an insulin delivery device. In some embodiments, the method may include receiving blood glucose (BG) data, determining one or more insulin sensitivity (IS) values associated with the BG data, and determining an insulin dose based on the determined one or more IS values. A system for carrying out such a method is also presented.01-31-2013
20100152651Frozen compositions and methods for piercing a substrate - Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.06-17-2010
20100114015Apparatus and method for controlling insulin infusion with state variable feedback - An infusion system, which may be a closed loop infusion system or “semi-closed-loop” system, uses state variable feedback to control the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The “semi-closed-loop” system further includes prompts that are displayed or sounded or otherwise provide indications to the user prior to fluid delivery. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The delivery system infuses a fluid into the user at a rate dictated by the commands from the controller. The system may use three state variables, subcutaneous insulin concentration, plasma insulin concentration, and insulin effect, and corresponding gains, to calculate an additional amount of fluid to be infused as a bolus and to be removed from the basal delivery of the fluid.05-06-2010
20100076371DEVICE AND METHOD EMPLOYING SHAPE MEMORY ALLOY - A system for the metering and delivery of small discrete volumes of liquid is comprised of a small or minimal number of inexpensive components. One such component is a movable member, such as a miniature precision reciprocating displacement pump head, which is driven by an actuator that comprises a shape memory alloy material. The operating mechanism of the system is of little or minimal complexity. The system facilitates the precise metering and delivery of the small discrete volumes of liquid. Potential applications for the system include subcutaneous, long-term, automated drug delivery, for example, the delivery of insulin to a person with diabetes. In such an application, the small, simple and inexpensive nature of the invention would allow for its use as both a portable and a disposable system.03-25-2010
20130079709INSULIN PUMP AND METHOD FOR CONTROLLING A USER INTERFACE OF AN INSULIN PUMP - An insulin pump comprises a pump device, a control for the pump device, a memory, an operating element for operating the insulin pump and a method for controlling a user interface of the insulin pump are disclosed. The control is designed and programmed such that options for the user of the insulin pump are displayed by the user interface as a function of a user-specific preference profile stored in the memory and as a function of a current time and are provided for selection by using the operating element. The insulin pump can be designed in an auto-adaptive fashion, such that the control continuously updates the user-specific preference profile based on analyzing operating inputs of the user. Embodiments of the invention allow a large range of functions and simple operation, even in the case of miniaturized pumps.03-28-2013
20130035632Decomposable Apparatus and Methods for Fabricating Same - The invention provides decomposing apparatus which comprises a first sub-component and a first micro device comprising a decomposable material, wherein the sub-component comprises a drug, a medical kit, a micro-disease detection system, or an auto-navigation system. Also within the invention are methods for fabricating such apparatus.02-07-2013
20130035633Selective Alarms for an Infusion Device - An infusion system to administer a fluid includes an infusion pump with a pump processor, a pump memory to store a plurality of configurable alarms and a pump radio to enable bi-directional communication. The infusion system further includes a controller that has a controller processor, a controller memory, a controller radio to transmit and receive communication from the pump radio. The controller further has a graphical user interface shown on a display along with controls to manipulate the graphical user interface. Furthermore, the bi-directional communication between the infusion pump and the controller establish an infusion pump relative proximity between the infusion pump and the controller such that when the infusion pump relative proximity exceeds a pump threshold distance at least one of the plurality of configurable alarm conditions of the infusion pump is modified.02-07-2013
20100145262SAFETY SYSTEM FOR INSULIN DELIVERY ADVISORY ALGORITHMS - A closed loop control system for a medical drug delivery device logs historical data such as drug delivered and corresponding physiological parameters such as blood glucose level. On the basis of the logged historical data, the system calculates an estimated event forecast on which basis the system further calculates the necessary, prudent future drug delivery profile in order to counter delay in the closed loop. The estimated event forecast is presented to the user, the user is thereby given the possibility to accept, reject or adjust the event forecast and the corresponding drug delivery profile. Dynamic and adaptive safety limits to the drug delivery and the physiological parameter can be set by the user and will dynamically follow the drug delivery profile and the event forecast and will further optimize based on the learned behavioural pattern of the user. The user can set the safety level as a percentage of deviation to the drug delivery profile.06-10-2010
20100042043AUTOMATIC DRUG ADMINISTRATION WITH REDUCED POWER CONSUMPTION - It is described a drug delivery system (02-18-2010
20100042042ENVIRONMENTAL STATE DETECTION WITH HYDROGEL BASED FULLY INTEGRATED TRANSDUCER DEVICE - It is described a hydrogel based transducer device for detecting an environmental state, in particular for detecting an environmental state within a biological material. The transducer device (02-18-2010
20090124964INTEGRATED DEVICE FOR CONTINUOUS IN VIVO ANALYTE DETECTION AND SIMULTANEOUS CONTROL OF AN INFUSION DEVICE - Systems and methods of use for continuous analyte measurement of a host's vascular system and the simultaneous control of a flow control device are provided. In some embodiments, an integrated system includes a vascular access device, a continuous analyte sensor, system electronics and an electronic cable for communication with a third-party infusion device, the system being configured for insertion into fluid communication with a host's circulatory system.05-14-2009
20100094202Device for the Time-controlled Intravenous Administering of the Anesthetic Propofol - The invention relates to a device for the time-controlled intravenous administering of the anesthetic propofol by means of a method used for determining an adequate dosage profile and adequately controlling an infusion pump as a metering apparatus.04-15-2010
20120165728COMMUNICATION PROTOCOL THAT SUPPORTS PASS-THRU COMMUNICATION - A private extension of the IEEE 11073 standard for enabling pass-thru communication between a external computing device and a medical device via a diabetes management device is disclosed herein. Within this context, a diabetes management system for configured to allow pass thru communication is described. The system includes a diabetes management device in communication with a external computing device and the first medical device. A pass-thru module of the diabetes management device uses a set of pass-thru commands for establishing a pass-thru communication path and enabling communication between the external computing device and the first medical device, and wherein the set of pass-through commands is defined in compliance with a communication protocol defined in accordance with IEEE standard 11073-20601.06-28-2012
20120296269INSULIN PUMP HAVING BASAL RATE TESTING FEATURES - Methods of establishing an insulin delivery rate in a pump and an insulin pump are disclosed. A method includes selecting a set of alerts from one or more sets of alerts. The method also includes initiating a test process based on the set of alerts. The method further includes, upon activation of each alert in the selected set of alerts, prompting a user to input a blood glucose level.11-22-2012
20090099507Device for Automatic Regulation of the Concentration of Glucose in the Blood of a Diabetes Patient - A device for regulating the concentration of glucose in the blood of a diabetes patient includes a measuring component for measuring the concentration, a pump component for selectively introducing glucagon, or glucose instead, or insulin into the body of the patient, for instance by way of at least one hypodermic needle to be inserted into the body of the patient; and a control component which receives signals from the measuring component which are representative of the concentration and which control the pump component on the basis of at least one reference value for the concentration pre-entered into the control component and a program; wherein the device is embodied such that the measuring component and the pump component can be in substantially permanent contact with the bodily fluid or the blood of a patient.04-16-2009
20110054390Extended Use Medical Device - Provided is an extended use self-contained, wearable medical device. The device is preferably configured with an infusion deployment mechanism for variably inserting and retracting an infusion needle to different depths, or completely retracting the infusion needle from the infusion site and then re-inserting the infusion needle after a predetermined period of time, throughout an infusion cycle for extending the viability of the infusion site. Another embodiment comprises dual needle deployment mechanisms which may also variably insert and retract the infusion needles. A flow sensor is preferably provided for detecting the stoppage of flow through the infusion cannula and signaling the needle deployment mechanism to attempt infusion at a different depth or to deploy a second infusion needle. A re-fillable reservoir assembly is preferably provided for supplying a drug over the extended use of the device. Another embodiment comprises a partially reusable and partially disposable medical device implementing the above features.03-03-2011
20110137238Disposable Wearable Insulin Dispensing Device, a Combination of Such a Device and a Programming Controller and a Method of Controlling the Operation of Such a Device - A wearable insulin dispensing device has features and operation characteristics supporting and easing compliance by the users of the device. For example, the device may provide capabilities of rendering a very specific and well-tuned dosage which may be altered according to the specific development of the individual user.06-09-2011
20110130716Activity Sensing Techniques for an Infusion Pump System - Some embodiments of a wearable infusion pump system can include a pump device having a drive system to dispense a medicine to a user, an activity sensor that detects a possible change in an activity level of the user, and a controller to activate the drive system to dispense the medicine to the user. The controller device can query the user to indicate whether a detected activity level of the user represents an actual change in the activity level of the user. The controller device can alter the medicine dispensing schedule based on the user indicated changes in activity level.06-02-2011
20090024079METHOD FOR CONTROLLING INSULIN PUMP USING BLUETOOTH PROTOCOL - A method for controlling an insulin pump using the Bluetooth protocol. The method comprises allocating IDs to insulin pumps and blood sugar level measuring devices, respectively; checking, in a corresponding insulin pump, whether or not blood sugar level data is inputted from a blood sugar level measuring device having a corresponding ID; cumulating inputted data and judging whether or not abnormality occurs; generating a command to allow the insulin pump to operate as it is, when abnormality did not occur; generating a command to change an insulin injection amount of the insulin pump when abnormality occurred, and then, returning to the third step; and determining a system to be out of order when data is not inputted in the checking step, and generating an alarm so that a qualified person can visit a corresponding patient to have a trouble to be directly addressed.01-22-2009
20130023820PATIENT-CONTROLLED ANALGESIA SAFETY SYSTEM - The patient-controlled analgesia (PCA) safety system includes a housing with a hollow compartment. A display and keypad are disposed on one side of the for display of monitoring data and selective commands respectively. An analgesic module and an antidote module are detachably mounted inside the compartment. A control module is disposed inside the housing. A vital signs monitor is connected to the control module to monitor a patient. In the event of abnormal readings due to, e.g., overdose or drug-related complications, the control module can automatically administer an antidote to the analgesia. The control module can also alert a nurse monitor and/or other personnel wirelessly to insure someone is notified of the potential emergency. The PCA safety system can also be provided in a separate safety module having a detachably mounted antidote module.01-24-2013
20110275986Apparatus and System for Diabetes Management - An apparatus and system diabetes management. The apparatus comprises a body which houses: (i) at least a first memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen and the patient's blood-glucose-level measurements determined at a plurality of times; (ii) a processor operatively connected to the at least first memory, the processor programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components of the patient's present insulin dosage regimen; (iii) a display screen operatively connected to the processor; (iv) a quantity of insulin; (v) a needle communicating with the quantity of insulin for delivering insulin to the patient; (vi) means for effecting delivery of a portion of the quantity of insulin to the patient via the needle; and (vii) metering means for controlling the portion of the quantity of insulin delivered to the patient via the needle.11-10-2011
20110288475INFUSION PRESSURE CONTROL USING BLOOD PRESSURE - Methods, systems, and software for controlling infusion pressure, such as during a medical procedure, using systemic blood pressure are described. Systemic blood pressure, such as brachial arm blood pressure or radial artery blood pressure, may be used to estimate central retinal artery blood pressure to estimate critical closing pressure. Further, the disclosure relates to controlling infusion pressure to prevent an increase in intraocular pressure above the estimated critical closing pressure when such is not desired, and, when such is desired, using systemic blood pressure and infusion pressure to control an intentional increase in intraocular pressure above the estimated critical closing pressure to stop intraocular bleeding.11-24-2011
20090043251Blood flow control system, tension adjustable instrument and method thereof - A blood flow control system, tension adjustable instrument and a method are disclosed. The blood. flow control system comprises a detecting unit, a computing and a tension adjustable instrument. The detecting unit real-time monitors the biomolecular response condition of a living organ, and the computing unit dynamically controls the tension adjustable instrument to adjust the tension of the blood vessel based on the detecting result. Therefore the blood flow control system can maintain the biomolecular response condition over a predetermined range to reduce the risk of the liver organ being damaged and augment the curability.02-12-2009
20090099509System for Providing Blood Glucose Measurements to an Infusion Device - An infusion system includes a characteristic determining device and an infusion device. The characteristic determining device includes a receptacle for receiving and testing an analyte from the user to determine a concentration of the analyte in the user. The characteristic determining device also includes a communication system for transmitting a communication including data indicative of the determined concentration of the analyte in the user, and the infusion device includes a communication system for receiving the communication from the characteristic determining device. The infusion device further includes a bolus estimator for calculating an estimated amount of fluid to be infused into the body of the user based upon the received data indicative of the determined concentration of the analyte in the user and a target concentration of the analyte in the user, and an indicator to indicate when the estimated amount of fluid to be infused has been calculated.04-16-2009
20090099508DEVICE FOR DRUG ADMINISTRATION AND/OR MONITORING THE STATUS OF A PATIENT - The invention relates to a device for drug administration and/or monitoring the status of a patient, the device comprising a first and a second measuring means, and the time for using the second measuring means being set in accordance with the data of the first measuring means.04-16-2009
20110270157Sensing and interactive drug delivery - An interactive drug delivery system includes a drug delivery module, an optical probe, a local controller, and an optional central controller. The drug delivery module is constructed and arranged to deliver selected amounts of a drug into a subject. The optical probe is constructed and arranged to detect in a selected tissue region of the subject a manifestation caused by the delivered drug. The local controller is constructed and arranged to receive data from or transmit data to the optical probe and the drug delivery module. The local controller is arranged to correlate optical data, received from the optical probe, to selected data and provide signals to the drug delivery module for adjusting the amounts of the drug to be delivered into the subject.11-03-2011
20090177144MICROMACHINED NEURAL PROBES - A neural probe includes at least one shaft, at least one first electrode disposed on a first side of the at least one shaft, and at least one second electrode disposed on a second side of the at least one shaft. The at least one second electrode is separately addressable from the at least first electrode.07-09-2009
20090149803System for Providing Blood Glucose Measurements to an Infusion Device - An infusion system includes a characteristic determining device and an infusion device. The characteristic determining device includes a receptacle for receiving and testing an analyte from the user to determine a concentration of the analyte in the user. The characteristic determining device also includes a communication system for transmitting a communication including data indicative of the determined concentration of the analyte in the user, and the infusion device includes a communication system for receiving the communication from the characteristic determining device. The infusion device further includes a bolus estimator for calculating an estimated amount of fluid to be infused into the body of the user based upon the received data indicative of the determined concentration of the analyte in the user and a target concentration of the analyte in the user, and an indicator to indicate when the estimated amount of fluid to be infused has been calculated.06-11-2009
20100268157SYSTEM AND METHOD FOR CONFIGURING A RULE SET FOR MEDICAL EVENT MANAGMENT AND RESPONSES - A system and method to configure a rule set used in connection with a medical monitoring system for monitoring patients and patient care equipment, especially medication delivery pumps, based on a variety of conditions and parameters associated with monitored biometric information and equipment information and for providing user-defined responses to those conditions and parameters.10-21-2010
20120109047TAILORED BASAL INSULIN DELIVERY SYSTEM AND METHOD - Disclosed is a system to deliver insulin to a user's body. The system includes a dispensing unit to deliver the insulin to the body, and a control mechanism to control delivery of basal insulin according to a predetermined basal infusion pattern, the basal infusion pattern selected from a plurality of predetermined basal infusion patterns. In some embodiments, selection of the basal infusion pattern may be based on one or more personal characteristics of the user.05-03-2012
20090177146APPARATUS AND METHODS FOR CONTROLLING AND AUTOMATING FLUID INFUSION ACTIVITIES - The present invention provides apparatuses and methods to safely and economically deliver infusion fluid to a patient during a medical procedure. The infusion fluid may be a sedative, analgesic, amnestic or other pharmaceutical agent (drug) for alleviating a patient's pain and anxiety before, during and/or after a medical or surgical procedure. In general the apparatus comprises a microprocessor-based controller that receives inputs from a plurality of physiological monitors attached to a patient. The system controller processes the data from the physiological monitors and based upon a fluid infusion algorithm delivers infusion fluid to a patient. The physiological monitors monitor the patient throughout the course of the procedure and depending upon the health of the patient, drug delivery may be adjusted to optimize the procedure while ensuring the patient's health and pain level are maintained.07-09-2009
20090275886DISPLAY FOR AN INSULIN PUMP - This document discusses, among other things, an apparatus comprising a pump configured to deliver insulin, a processor, and a user interface including a bistable display. A display element of the bistable display is placed in one of two stable orientations upon application of a biasing voltage and stays in the stable orientation when the biasing voltage is removed. The processor includes a display module configured to display a non-blank reversion display screen on the bistable display when no input is received at the user interface after a specified time duration, and to recurrently change the reversion display screen until input is received at the user interface.11-05-2009
20080275384CLOSED LOOP/SEMI-CLOSED LOOP THERAPY MODIFICATION SYSTEM - A closed loop/semi-closed loop infusion system provides therapy modification and safeguards against the over-delivery or under-delivery of insulin. A glucose sensor system is configured to obtain a measured blood glucose value. A controller is operationally connected with the glucose sensor system and configured to trigger an alarm based on a measured blood glucose value or amount of insulin delivered, selectively perform calibration of the glucose sensor system when the alarm is triggered, and adjust a therapy delivery parameter when the alarm is triggered, wherein the adjusted therapy delivery parameter is limited to be within a boundary. Thereafter, a delivery system delivers therapy at the adjusted therapy delivery parameter.11-06-2008
20100298766Device for passively removing a target component from blood or lymph of a vertebrate subject - Devices, systems, and methods are described herein for controlling or modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject. Devices and systems are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to fluid flow into the at least one lumen; at least one first reservoir disposed within the body and configured to include one or more bifunctional tags, wherein the one or more bifunctional tags are configured to selectively bind to one or more target components in one or more of blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; and at least one second reservoir disposed in the at least one treatment region and configured to include one or more reactive components, wherein the one or more reactive components are configured to sequester the one or more bifunctional tags when bound to the one or more target components.11-25-2010
20100137786SYSTEM AND METHOD FOR ACTIVELY MANAGING TYPE 1 DIABETES MELLITUS ON A PERSONALIZED BASIS - A system and method for actively managing Type 1 diabetes mellitus on a personalized basis is provided. Models of glycemic effect for a Type 1 diabetic patient are established for both insulin time course and digestive response. A rise in postprandial blood glucose is estimated through food ingestion of a planned meal in proportion to the digestive response model. An amount of insulin necessary and timing of delivery to mediate transport of blood glucose into cells in proportion to the postprandial blood glucose rise is determined through the insulin time course model.06-03-2010
20110270159Communications System for an Implantable Medical Device and a Delivery Device - A method for monitoring drug dose, intake and effectiveness includes a drug delivery device in data communications with at least one implantable medical device. The method is preferably implemented in a web-enabled environment in which a remote data center communicates with the implantable devices (IMDs) in a patient via a programmer or the pill dispenser. The method may include facilitating access by a physician, clinician, or other user of the remote data center to review and monitor the IMDs or the drug delivery regime remotely. The method further provides a dynamic drug management system, compatible with a web-enabled interactive data communication environment that accurately monitors dose and specific drug effectiveness in a patient to enhance patient care.11-03-2011
20110270158INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR - Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.11-03-2011
20100137789DRUG DELIVERY PRESENTATION AND ARRANGEMENT FOR DRUG DELIVERY PRESENTATION - A drug delivery presentation is disclosed herein. The drug delivery presentation includes a display for showing a concentration of at least two different types of drugs including a first drug and a second drug for a subject, and also for showing a coordinate system for a variable first drug concentration and a variable second drug concentration. The drug delivery presentation also includes an optimal therapy mixture area presented on a coordinate system comprising a first border section determining a minimum concentration mixture for the first drug and the second drug. The optimal therapy mixture area further comprising a second border section determining a maximum concentration mixture for the first drug and the second drug. An arrangement for a drug delivery presentation is also disclosed.06-03-2010
20090264814DEVICE FOR MEDICAL TREATMENT DECISION SUPPORT AND/OR MONITORING THE STATUS OF A PATIENT - The invention relates to a device for medical treatment decision support and/or monitoring the status of a patient, the device comprising a first measuring means at the ipsilateral side and a second measuring means at the contralateral side and a comparison means in order to find the optimal and/or suboptimal time for drug treatment and/or other medical treatment steps.10-22-2009
20080243056Controllable release nasal system - Embodiments of devices and system for controllable nasal delivery of materials are described. Methods of use of such devices and system and software for controlling the operation of such devices and systems are also disclosed.10-02-2008
20080269672Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.10-30-2008
20090177143USE OF AN EQUILIBRIUM INTRAVASCULAR SENSOR TO ACHIEVE TIGHT GLYCEMIC CONTROL - A method for achieving tight glycemic control in a patient in need thereof is disclosed. The method comprises deploying an equilibrium glucose sensor within a blood vessel in the patient, coupling the sensor to a monitor that displays the blood glucose concentration, and administering a blood glucose regulator when the blood glucose concentration varies outside of the predetermined concentration range. The blood glucose regulator is administered in an amount sufficient to return the blood glucose concentration to within the predetermined concentration range, thereby achieving tight glycemic control.07-09-2009
20090131860Medical Skin Mountable Device And System - A medical device is provided comprising a transcutaneous device unit and a process unit. The transcutaneous device unit may comprise a transcutaneous device for transporting a fluid through a skin portion of a subject, and a mounting surface adapted for application to the skin of the subject. The process unit may comprise a reservoir adapted to contain a fluid drug, the reservoir comprising an outlet means allowing the transcutaneous device to be arranged in fluid communication with an interior of the reservoir, and an expelling assembly for expelling a fluid drug out of the reservoir and through the skin of the subject via the transcutaneous device. The transcutaneous device unit and the process unit further comprise coupling means allowing the reservoir unit to be secured to the transcutaneous device unit in the situation of use. By this arrangement a two-unit system is provided which can be used in a convenient and cost-effective manner.05-21-2009
20090005728THERAPY DELIVERY SYSTEM HAVING AN OPEN ARCHITECTURE AND A METHOD THEREOF - A therapy delivery system having an open architecture and method of providing thereof are disclosed. The present invention provides a therapy dosage module having a control algorithm that can be replaced with a predefined or independently defined control algorithm. The tools necessary to create and test such control algorithms in the therapy dosage module in a simulated environment before implementing it in a live therapy system are also disclosed.01-01-2009
20090177145MEDICAL DEVICE AND METHOD FOR MONITORING HEMATOCRIT AND SVO2 - A method, an implantable medical device, and a computer-readable medium encoded with programming instructions allow monitoring of a hematocrit value and an SvO2 level of a patient, making use of at least one medical lead connected to an implantable medical device that carries an optical sensor module that measures at least one hematocrit value and at least one SvO2 value using at least first, second and third light radiation wavelengths, by determining a present hematocrit value from at least one of the measured hematocrit values and determining a present SvO2 value from at least one of the measured SvO2 values, and determining a patient status by evaluating the present hematocrit value and the present SvO2 value, to allow a change in the patient status to be identified.07-09-2009
20090177142INSULIN PUMP WITH ADD-ON MODULES - This document discusses, among other things, an apparatus comprising a pump configured to deliver insulin, a wireless communication port, a controller, and a housing to enclose the apparatus. The controller is configured to communicate with a second device via the communication port using an open standard wireless communication protocol. The housing includes a mechanical coupling to slidably engage the second device which includes a second wireless communication port. Slidably engaging the second device positions the first and second communication ports opposite each other to allow communication via the first and second communication ports when slidably engaged.07-09-2009
20090143725Method of Optimizing Efficacy of Therapeutic Agent - Method and device for outputting one or more signals associated with a monitored analyte level of an individual, the one or more signals including a substantially real time monitored analyte level and a rate of change information associated with the monitored analyte level, outputting a carbohydrate intake event indication, determining one or more data associated with one or more therapy information related to the monitored analyte level and the meal event indication, and outputting the determined one or more data over the outputted one or more signals associated with the monitored analyte level and the carbohydrate intake event indication are provided.06-04-2009
20080319382METHOD AND APPARATUS FOR COUPLING A CHANNELED SAMPLE PROBE TO TISSUE - Sampling is controlled in order to enhance analyte concentration estimation derived from noninvasive sampling. More particularly, sampling is controlled using controlled fluid delivery to a region between a tip of a sample probe and a tissue measurement site. The controlled fluid delivery enhances coverage of a skin sample site with the thin layer of fluid. Delivery of contact fluid is controlled in terms of spatial delivery, volume, thickness, distribution, temperature, and/or pressure.12-25-2008
20110224602CARDIAC RELATED NEURAL ACTIVITY - The present invention relates to a medical device for analyzing cardiac related input signals. The device is capable of receiving an ECG-signal and a nerve activity signal, such as vagus nerve signal in order to detect a cardiac related neural activity, such as epilepsy. The device is programmed for detecting a trigger feature (e.g. the R-peak) in the signal and extracting a nerve activity signal segment from the nerve activity signal in response to detecting the trigger feature. An activity related feature is generated either based on a combined signal obtained from a number of nerve activity signal segments,or as a segment-based activity related feature obtained from a number of nerve activity signal segments. Moreover, the device is adapted for comparing the activity related feature to a predefine criterion in order to detect the cardiac related neural activity.09-15-2011
20080306435INTEGRATED MEDICAMENT DELIVERY DEVICE FOR USE WITH CONTINUOUS ANALYTE SENSOR - An integrated system for the monitoring and treating diabetes is provided, including an integrated receiver/hand-held medicament injection pen, including electronics, for use with a continuous glucose sensor. In some embodiments, the receiver is configured to receive continuous glucose sensor data, to calculate a medicament therapy (e.g., via the integrated system electronics) and to automatically set a bolus dose of the integrated hand-held medicament injection pen, whereby the user can manually inject the bolus dose of medicament into the host. In some embodiments, the integrated receiver and hand-held medicament injection pen are integrally formed, while in other embodiments they are detachably connected and communicated via mutually engaging electrical contacts and/or via wireless communication.12-11-2008
20080306434INTEGRATED MEDICAMENT DELIVERY DEVICE FOR USE WITH CONTINUOUS ANALYTE SENSOR - An integrated system for the monitoring and treating diabetes is provided, including an integrated receiver/hand-held medicament injection pen, including electronics, for use with a continuous glucose sensor. In some embodiments, the receiver is configured to receive continuous glucose sensor data, to calculate a medicament therapy (e.g., via the integrated system electronics) and to automatically set a bolus dose of the integrated hand-held medicament injection pen, whereby the user can manually inject the bolus dose of medicament into the host. In some embodiments, the integrated receiver and hand-held medicament injection pen are integrally formed, while in other embodiments they are detachably connected and communicated via mutually engaging electrical contacts and/or via wireless communication.12-11-2008
20090198175Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.08-06-2009
20110144573BIO-MEDICAL UNIT SYSTEM FOR MEDICATION CONTROL - A system includes bio-medical units, a wireless communication module, and a wireless power source. A bio-medical unit includes a power harvesting module, a communication module, a processing module, and a medication control module for performing a medication control function and generating a medication response. The wireless communication module is operable to wirelessly communicate inbound and outbound wireless signals with the bio-medical unit. The wireless power source is operable to generate the electromagnetic signal, which the power harvesting module converts into a supply voltage that powers the other modules of the bio-medical unit.06-16-2011
20110230824Burn Patient Resuscitation System - A method and system for operating a semi-closed loop and/or a closed loop resuscitation of a burn patient in view of patient information and other physiological data gathered as part of the method and/or by the system. The method in at least one embodiment includes receiving patient information, calculating an infusion rate based at least on part on a portion of the received patient information, outputting the infusion rate to an infusion pump, obtaining a urinary output, calculating a new infusion rate using infusion rate model based constants, and outputting the new infusion rate to an infusion pump. In some embodiments, the method includes notifying medical staff when problems arise, displaying information regarding the resuscitation, and setting limits regarding the infusion rates.09-22-2011
20080262418Automated Therapy System and Method - An automated therapy system having an infusion catheter; a sensor adapted to sense a patient parameter; and a controller communicating with the sensor and programmed to control flow output from the infusion catheter into a patient based on the patient parameter without removing fluid from the patient. The invention also includes a method of controlling infusion of a fluid to a patient. The method includes the following steps: monitoring a patient parameter with a sensor to generate a sensor signal; providing the sensor signal to a controller; and adjusting fluid flow to the patient based on the sensor signal without removing fluid from the patient.10-23-2008
20090137947System and method of wireless physiological signal integration - A system of a wireless physiological signal integration is provided. The system includes a wireless transmission sensor chip and a drug delivering system, wherein the wireless transmission sensor chip includes a sensor sensing a physiological signal of a patient, a signal conversion module converting the physiological signal into a converted signal, and a wireless transmission module wirelessly transmitting the converted signal, and the drug delivering system determines a dose of a drug and a timing for providing the drug according to the converted signal.05-28-2009
20090209904Diagnostic Radio Frequency Identification Sensors And Applications Thereof - An integrated passive wireless chip diagnostic sensor system is described that can be interrogated remotely with a wireless device such as a modified cell phone incorporating multi-protocol RFID reader capabilities (such as the emerging Gen-2 standard) or Bluetooth, providing universal easy to use, low cost and immediate quantitative analyses, geolocation and sensor networking capabilities to users of the technology. The present invention can be integrated into various diagnostic platforms and is applicable for use with low power sensors such as thin films, MEMS, electrochemical, thermal, resistive, nano or microfluidic sensor technologies. Applications of the present invention include on-the-spot medical and self-diagnostics on smart skin patches, Point-of-Care (POC) analyses, food diagnostics, pathogen detection, disease-specific wireless biomarker detection, remote structural stresses detection and sensor networks for industrial or Homeland Security using low cost wireless devices such as modified cell phones.08-20-2009
20090221956MULTI-PARAMETER MONITORING DEVICE FOR USE WITH CENTRAL AND INTRAVENOUS ADMINISTRATION OF MEDICATION - The invention generally relates to a multi-parameter monitoring device for in-line use to monitor a therapeutic agent solution passing therethrough prior to being centrally administered in connection with treatment of a CNS-related condition or disorder, e.g., a neuro-psychiatric disorder. In another aspect, the invention relates to a multi-parameter monitoring device for in-line use to monitor a therapeutic agent solution passing therethrough prior to being (a) intravenously administered to a patient in connection with a treatment, such as is the case where the therapeutic agent solution comprises an IV administerable solution, or (b) administered to a patient in connection with a treatment for diabetes, such as is the case where the therapeutic agent comprises insulin.09-03-2009
20090240194ENERGY BALANCE THERAPY FOR OBESITY MANAGEMENT - Techniques are described that allow an implantable device to sense gastric data and activity data from a patient, and estimate the patient's amount of energy consumed and energy expended based on the sensed data. A system provides feedback to the patient, a family member, or a doctor about the patient's energy consumed, energy expended, and net energy. The data may be provided in table or graphical format, and may show daily or weekly energy balance data or may show a trend of the daily or weekly energy data. The patient may receive feedback by an implanted alert module that provides and audio alert or a vibration alert. In addition, data acquired by the system may be used to adjust the patient's stimulation therapy parameters.09-24-2009
20090240193SYSTEMS AND METHODS FOR CUSTOMIZING DELIVERY OF SENSOR DATA - Systems and methods for continuous measurement of an analyte in a host are provided. The system generally includes a continuous analyte sensor configured to continuously measure a concentration of analyte in a host and a sensor electronics module physically connected to the continuous analyte sensor during sensor use, wherein the sensor electronics module is further configured to directly wirelessly communicate displayable sensor information to a plurality of different types of display devices.09-24-2009
20130190682METHODS AND SYSTEMS FOR CONTROLLING MEDICAL ENVIRONMENTS - A system for controlling an environment of a patient undergoing an surgical procedure is provided. The system includes a conduit configured to channel fluids towards the patient, a sensor configured to measure at least one operating parameter of the fluid being channeled to the patient, an effector configured to change the operating parameter of the fluid, and a controller configured to selectively activate the effector based on a signal received from the sensor.07-25-2013
20100274181SMART SENSOR PORTS AND METHODS OF USING SAME - The present disclosure provides an orientation-nonspecific sensor port for use in analyte meters designed to detect and quantify analyte levels in a fluid sample along with methods of using the same. The present disclosure also provides compositions and methods for facilitating the correct insertion of a sensor into a corresponding analyte meter.10-28-2010
20090254024ARRAY AND METHOD FOR DOSING A HORMONE REGULATING BLOOD SUGAR IN A PATIENT - The invention concerns an array and a method for dosing a hormone regulating the blood glucose, especially insulin, of a diabetic patient (10-08-2009
20100174230MODULAR EXTERNAL INFUSION DEVICE - A modular external infusion device that controls the rate a fluid is infused into an individual's body, which includes a first module and a second module. More particularly, the first module may be a pumping module that delivers a fluid, such as a medication, to a patient while the second module may be a programming module that allows a user to select pump flow commands. The second module is removably attachable to the first module.07-08-2010
20100174229SYSTEM AND METHOD FOR AUTHORIZED MEDICATION DELIVERY - A system and method for verifying identification of an authorized person by biometrics prior to a patient controlled analgesic medication delivery to the patient and for monitoring the delivery of medication to a patient is disclosed, along with a monitoring system and method for controlling medication delivery based on at least one monitored patient condition.07-08-2010
20100185142Systems and Methods for Fluid Delivery - A system for at least partial closed-loop control of a medical condition is disclosed. The system includes at least one medical fluid pump. The medical fluid pump including a sensor for determining the volume of fluid pumped by the pump. Also, at least one continuous analyte monitor, and a controller. The controller is in communication with the medical fluid pump and the at least one continuous analyte monitor. The controller includes a processor. The processor includes instructions for delivery of medical fluid based at least on data received from the at least one continuous analyte monitor.07-22-2010
20100160855PORTABLE DRUG ADMINISTRATION DEVICE AND METHOD FOR CONTROLLING A PORTABLE DRUG ADMINISTRATION DEVICE - A portable drug administration device includes a pump and a controller configured to control operation of the pump according to a standard administration mode and a suspend mode in which drug administration is temporarily suspended. The device is configured to generate an event trigger on the occurrence of at least one of an error condition and/or the beginning of a maintenance action by the user. The controller is configured to detect the occurrence of the event trigger, and to store, in response to the event trigger, administration data, the administration data comprising all information that characterizes the current administration according at the time of occurrence of the event trigger automatically in a memory and to switch the device from the standard administration mode to the suspend mode. The controller is further configured to detect the occurrence of a restoring trigger and to retrieve, in response to the restoring trigger, the administration data from the memory, to switch the device from the suspend mode to the standard administration mode and to control the pump to resume administration according to the retrieved administration data.06-24-2010
20100228186Operating A Portable Medical Device - Some embodiments of a portable medical device, such as an infusion pump, can receive an external reference signal (e.g., a radio, cellular and/or satellite signal) to provide an automatic time-setting and maintenance operation. In these circumstances, the medical device can maintain accurate time and date information even in the event of a power interruption, a time-zone change and/or an internal clock error, for example. In this manner, the portable medical device provides safe operation and added convenience to the user.09-09-2010
20100137787Delivery devices for modulating inflammation - Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that modulate at least one inflammatory response or reaction. According to various embodiments, the compositions, methods, devices, and systems relate to modulating one or more of Toll-like receptors, Src family kinases, NF-kB molecules, proteases, or proteasomes.06-03-2010
20100056993Medical Systems and Methods of Use - This invention provides ambulatory medical systems that include a monitoring device, a therapeutic substance administering device, and a receiver-controller for receiving a signal generated by the monitoring device and controlling the therapeutic substance administering device based on the information received from the monitoring device. The invention also provides methods for using the same.03-04-2010
20100198142Multi-Function Analyte Test Device and Methods Therefor - Methods, systems and devices for detecting an analyte sample, determining an analyte concentration associated with the detected analyte sample, retrieving stored one or more dose determination information and associated analyte concentration associated with the retrieved one or more dose determination information, and determining a current dose level based at least in part on the determined analyte concentration and the retrieved prior dose determination information, where the determined current dose level includes a predetermined type of medication classification are provided. For example, dosage determination of fast or rapid acting insulin, long acting insulin, intermediate acting insulin, or one or more combinations may be provided to assist in the management of diabetes and related conditions.08-05-2010
20100198143System for Providing Blood Glucose Measurements to an Infusion Device - An infusion system includes a characteristic determining device and an infusion device. The characteristic determining device includes a receptacle for receiving and testing an analyte from the user to determine a concentration of the analyte in the user. The characteristic determining device also includes a communication system for transmitting a communication including data indicative of the determined concentration of the analyte in the user, and the infusion device includes a communication system for receiving the communication from the characteristic determining device. The infusion device further includes a bolus estimator for calculating an estimated amount of fluid to be infused into the body of the user based upon the received data indicative of the determined concentration of the analyte in the user and a target concentration of the analyte in the user, and an indicator to indicate when the estimated amount of fluid to be infused has been calculated.08-05-2010
20090112154User Interface for Insulin Infusion Device - The invention relates to a device and method for treating diabetic patients on insulin therapy. More specifically, the invention includes apparatus for infusing insulin into a patient in an amount determined by the patient's carbohydrate intake, blood glucose level, and the amount of insulin calculated to be present in the patient at the time the therapy is to be administered. In one embodiment, an insulin infusion device having an on-board processor obtains a patient's blood glucose value from a remote sensor and receives input from a user indicating their recent meal intake. The device may include an on-board food database for determining the carbohydrate content of the patient's recent meals and compare that with recent insulin deliveries into the patient to determine the insulin present in the patient prior to determining an appropriate insulin dosage.04-30-2009
20090105636Closed Loop Control System With Safety Parameters And Methods - Methods, system and devices for monitoring a plurality of parameters associated with a closed loop control operation including continuously monitoring a physiological condition and automatic administration of a medication, detecting an adverse condition associated with the monitored physiological condition or the medication administration deviating from a predetermined safety level of the closed loop control operation, and initiating a non-zero pre-programmed medication delivery rate are provided.04-23-2009
20130131587MEDICAL EQUIPMENT SYSTEM - The invention is directed to a medical equipment system by means of which the provision of medication to a patient is adapted according to continuously recorded physiological measurement signals. The object of the invention is to find ways by which medication can be administered to a patient with a high degree of accuracy. This object is achieved, according to the invention, by a medical equipment system with a spectrometer for recording measurement signals from vital tissue of a patient, in particular for continuously determining the material composition of body liquids and also of tissue-bound substances possibly present only temporarily in the corresponding tissue area, with a signal processor for processing the measurement signals supplied from the spectrometer and for generating a medication signal, and with medication equipment for administering a medicament according to the medication signal.05-23-2013
20090069744Glucose Measuring Device Integrated Into A Holster For A Personal Area Network Device - A glucose meter module integrated into a holster device that can securely accommodate another device such as a portable server device or an insulin pump is described. The glucose measuring module and the health device communicate with each other by a short range wireless modality. In the case in which the accommodated device is a server, such as personal digital assistant or cell phone, the device stores data in a memory, displays data on a visual display, and can wirelessly transmit such data to other devices within a personal area network. In the case where the accommodated device is a cell phone, the phone can further transmit data to remote sites. In the case where the accommodated device is an insulin pump, wirelessly received data are stored in a memory, are available for visual display on the insulin pump, and can be incorporated into the electronic processes that regulate the performance of the pump.03-12-2009
20090069743INFUSION THERAPY SENSOR SYSTEM - A sensor system for use with an infusion system may include at least one sensor disposed within a catheter, the at least one sensor comprising at least one of an optical sensor, an electrical sensor or a chemical/biochemical sensor. The sensor system may instead include a sample cell that is in fluid communication with the infusion system, which sample cell may be used with an analyzer to determine a patient's condition. The sensor system may be integrated with a control system for an infusion pump to control operation of the pump.03-12-2009
20090036828Method and System for Self-Management of a Disease - The present specification discloses a method, system and program product that can be used for self-management of any chronic disease. The invention involves the use of a device to enter patient's disease related data. Based on this data patient's habits are detected and presented in a graphical format. The user also has the option of setting up a reminder based on the detected habits.02-05-2009
20110009813PANNING A DISPLAY OF A PORTABLE MEDICAL DEVICE - In a medical device having a display element, a method of providing an intuitive graphical display of patient data begins by obtaining measurement data corresponding to values of a physiological characteristic measured over a period of time. The method continues by rendering a graphical representation of a portion of the measurement data on the display element, resulting in a display of the values of the physiological characteristic measured during a first interval of the period of time. Thereafter, the method processes a user-initiated display panning command and, in response to the user-initiated display panning command, dynamically pans the graphical representation while updating the portion of the measurement data. Thereafter, the method renders a display of the values of the physiological characteristic measured during a second interval of the period of time.01-13-2011
20100331771INTEGRATED DEVICES HAVING EXTRUDED ELECTRODE STRUCTURES AND METHODS OF USING SAME - The present disclosure provides electrode structures and integrated electrode structures having one or more conductive materials coextruded with one or more dielectric materials. The disclosed electrode structures can be configured for use as analyte sensors. Also provided, are methods of making and using the electrode structures and integrated electrode structures described herein.12-30-2010
20110040246ANALYTE SENSOR PORTS - The present disclosure provides a contamination resistant sensor port which includes one or more sealing members positioned so as to limit and/or prevent internal contamination of the sensor port with fluids and/or particles present in the environment outside the sensor port.02-17-2011
20110040248METHODS AND IMPLANTABLE DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS - A medication, method and device for cardiac treatment are provided, in particular, for treating supraventricular arrhythmias. Specifically, a method is provided for treating supraventricular arrhythmias, using a therapeutically effective amount of a cholinergic receptor agonist, for example, acetylcholine. This device may be part of universal device which provides pacing and defibrillation. In particular, the present invention can be used to treat atrial fibrillation, atrial flutter and atrial tachycardia by a bolus injection of a rapidly hydrolysable cholinergic receptor agonist such as acetylcholine.02-17-2011
20110040247INFUSION PUMP METHODS AND SYSTEMS - A medical remote controller device is disclosed. The device includes a display and at least one input switch dedicated to bolus delivery wherein a bolus delivery is programmed when the input switch receives an input and wherein the number of inputs received by the input switch determines the amount of bolus to be delivered.02-17-2011
20090062729CONTROLLING BODY FLUID CONDITION USING DIURETICS - The system for controlling body fluids overcomes the limitations of the prior art by automatically infusing diuretic and/or other drugs into a human patient. In one approach, the rate of infusion of the diuretic is adjusted based on the measured weight of the patient. For example, this weight can be transmitted wirelessly to a portable diuretic infusion device attached to the patient.03-05-2009
20090062730CONTROL OF BODY FLUID CONDITION USING DIURETICS, BASED ON BIOLOGICAL PARAMETERS - The system for controlling body fluids overcomes the limitations of the prior art by automatically infusing diuretic and/or other drugs into a human patient. In one approach, the rate of infusion of the diuretic is adjusted based on a measured biological parameter of the patient. For example, this biological parameter can be transmitted wirelessly to a portable diuretic infusion device attached to the patient.03-05-2009
20100063438Fluid Delivery Device With Integrated Monitoring Of Physiological Characteristics - The present application relates to a drug delivery device (03-11-2010
20100056992Variable Rate Closed Loop Control And Methods - Methods, system and devices for monitoring a closed loop control operation including signal levels received from an analyte sensor at a predetermined frequency, determining a variation in the monitored analyte level, determining a medication delivery rate adjustment frequency to deliver a medication based on the determined variation in the monitored analyte level, and adjusting the closed loop control operation to modify the medication delivery rate frequency are provided.03-04-2010
20110098638Sensor-Augmented Medication Infusion System - A sensor-augmented medication infusion system includes a sensor attached to a body of a user to detect an analyte level of the user. An infusion device is adapted to be carried by the user that includes a drive mechanism operatively coupled to a reservoir containing a fluid to infuse the fluid into the body of the user, a processor operatively coupled to the drive mechanism to control the drive mechanism, a communication receiver operatively coupled to the processor to receive data from the sensor corresponding to the analyte level of the user, and a display screen operatively coupled to the processor to display the data corresponding to the analyte level of the user, wherein the infusion device includes a user-selectable function to disable the infusion device from infusing the fluid into the body of the user while continuing to display the data corresponding to the analyte level of the user on the display screen.04-28-2011
20110098637Method and System for Configuring an Insulin Infusion Device - A method of configuring an insulin infusion device includes receiving body weight information of a patient or total daily dose (TDD) information of the patient. The insulin infusion device is programmed for operation based on the received information and default rules.04-28-2011
20110071464SEMI-CLOSED LOOP INSULIN DELIVERY - Subject matter disclosed herein relates to a semi-closed loop drug delivery system. In particular embodiments, an amount of insulin to be administered to a patient may be calculated based, at least in part, on one or more blood-glucose measurements obtained from said patient, and an alarm may be initiated in response to the calculated amount of insulin. At least a portion of the calculated amount of insulin may then be injected into the patient in the absence of a response to the alarm within a time limit.03-24-2011
20100298765SAFETY FEATURES FOR INTEGRATED INSULIN DELIVERY SYSTEM - Safety features are applied to an integrated insulin delivery system to enhance safety while accounting for glucose sensor bias and calibration errors. One safety feature includes comparisons of calibrations of the sensor to nominal sensitivity and taking action, such as limiting insulin delivery or taking a further calibration of the sensor. In another feature, an automatic resumption of a basal delivery rate is programmed into the delivery device to avoid the possibility of complete loss of delivery of insulin in the event that communication with the delivery device is disrupted. Other features include steps taken to avoid hypoglycemia in the event that the sensor is negatively biased.11-25-2010
20090299276INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR - Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.12-03-2009
20120203166APPARATUS AND METHOD FOR PROCESSING GLYCEMIC DATA - Apparatus for processing a glycemic value, having: a transformer for transforming the glycemic value into a transformed glycemic value, wherein the transformer is configured for applying a transform rule to the glycemic value, the transform rule having a combination of a first logarithmic term having a logarithm of the glycemic value, and of a second linear term having a linear contribution of the glycemic value, wherein the transform rule is such that, for each glycemic value of a set of glycemic values having more than one glycemic value, the first logarithmic term and the second linear term both influence the corresponding transformed glycemic value.08-09-2012
20110009814INFUSION PUMP - Described is an infusion pump comprising electronic infusion regulating means with wired or wireless communication means and a power source, a medicament bag (01-13-2011
20110054391ANALYTE SENSING AND RESPONSE SYSTEM - Electrochemical systems for measuring an analyte concentration, and correcting any surplus or deficiency in the measured concentration. More specifically, systems for measuring an analyte level in a fluid with an implantable sensor, processing the measurements with a front-loaded delivery algorithm having a fluid delivery period and a refractory period, and determining an appropriate fluid infusion rate in response to the measurements.03-03-2011
20110021978DRUG DELIVERY SYSTEM INCLUDING A DRUG-CONTAINER HOLDER AND A PUMP ASSEMBLY - A first drug delivery system includes first and second drug-container holders and first and second pump assemblies. The first (second) holder is adapted to receive a first (second) drug container having a first (a different second) dimensioned shape but not a second (first) drug container having a different second (a first) dimensioned shape. A second drug delivery system includes first and second bar code scanners, first and second drug-container holders, and first and second pump assemblies. The first (second) holder is adapted to receive a first (second) drug container having a dimensioned shape and to orient a positioned first (second) bar code of the first (second) drug container to face the first (second) bar code scanner because of the dimensioned shape. In one application, the first drug is a sedative drug, the second drug is an analgesic drug, and the drugs are used during a conscious sedation medical procedure.01-27-2011
20110264035Method and System for Adaptive Communication Transmission - Disclosed are methods, systems, devices and articles, including method for adaptive wireless communication transmissions between units of an ambulatory portable medical device. The method includes obtaining data relating to wireless transmissions between the units of the medical device, and setting one or more attributes of wireless transmission of one or more messages between the units of the medical device based, at least in part, on the obtained data.10-27-2011
20110118661Implantable system enabling responsive therapy for pain - An implantable neurostimulator system for treating pain includes scheduled and responsive therapy capabilities including responsive stimulation applied to the brain and peripheral sections of the nervous system. Methods for treating chronic nociceptive, neuropathic, and psychogenic pain employ an inventive system to advantageously reduce multiple symptoms and components of pain and to address underlying causes of pain.05-19-2011
20100168658Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.07-01-2010
20100280445Patient hydration system with taper down function - A patient hydration system including an infusion device for administering hydration fluid to a patient, and a hydration fluid measurement device responsive to a source of hydration fluid, a patient urine output measurement device. A controller is responsive to the hydration fluid measurement device and the patient urine output measurement device. The controller operates the infusion device, in response to the patient urine output measurement device and the hydration fluid measurement device, to hydrate the patient based on the patient's urine output. The controller also monitors the operation history of the infusion device thereby providing redundancy in the measurement of the amount of hydration fluid administered to the patient.11-04-2010
20100280444Patient hydration system with abnormal reading detection - A patient hydration system including an infusion device for administering hydration fluid to a patient, and a hydration fluid measurement device responsive to a source of hydration fluid, a patient urine output measurement device. A controller is responsive to the hydration fluid measurement device and the patient urine output measurement device. The controller operates the infusion device, in response to the patient urine output measurement device and the hydration fluid measurement device, to hydrate the patient based on the patient's urine output. The controller also monitors the operation history of the infusion device thereby providing redundancy in the measurement of the amount of hydration fluid administered to the patient.11-04-2010
20100280443Patient hydration system with redundant monitoring - A patient hydration system including an infusion device for administering hydration fluid to a patient, and a hydration fluid measurement device responsive to a source of hydration fluid, a patient urine output measurement device. A controller is responsive to the hydration fluid measurement device and the patient urine output measurement device. The controller operates the infusion device, in response to the patient urine output measurement device and the hydration fluid measurement device, to hydrate the patient based on the patient' s urine output. The controller also monitors the operation history of the infusion device thereby providing redundancy in the measurement of the amount of hydration fluid administered to the patient.11-04-2010
20100280442Replay device for transferring information between a sensor system and a fluid delivery system - A relay device transfers information between a sensor system, which measures a physiological characteristic level of a user, and a fluid delivery system, which infuses a fluid into a user. The relay device includes a sensor system receiver for receiving communications from the sensor system in a sensor system format. The relay device also includes a processor for processing the communications from the sensor system and converting the communications for transmission in a delivery system format. The relay device further includes a delivery system transmitter for transmitting the converted communications in the delivery system format to the fluid delivery system. The sensor system and delivery system formats may utilize different frequencies and/or different communication protocols for communications transmitted between the sensor system and the fluid delivery system through the relay device.11-04-2010
20100280441OVERNIGHT CLOSED-LOOP INSULIN DELIVERY WITH MODEL PREDICTIVE CONTROL AND GLUCOSE MEASUREMENT ERROR MODEL - A closed-loop system for insulin infusion overnight uses a model predictive control algorithm (“MPC”). Used with the MPC is a glucose measurement error model which was derived from actual glucose sensor error data. That sensor error data included both a sensor artifacts component, including dropouts, and a persistent error component, including calibration error, all of which was obtained experimentally from living subjects. The MPC algorithm advised on insulin infusion every fifteen minutes. Sensor glucose input to the MPC was obtained by combining model-calculated, noise-free interstitial glucose with experimentally-derived transient and persistent sensor artifacts associated with the FreeStyle Navigator® Continuous Glucose Monitor System (“FSN”). The incidence of severe and significant hypoglycemia reduced 2300- and 200-fold, respectively, during simulated overnight closed-loop control with the MPC algorithm using the glucose measurement error model suggesting that the continuous glucose monitoring technologies facilitate safe closed-loop insulin delivery.11-04-2010
20100280440POSTURE-RESPONSIVE THERAPY CONTROL BASED ON PATIENT INPUT - Patient efficacy inputs are received over a period of time during which posture-responsive therapy is delivered to the patient while the patient occupies a plurality of posture states. The patient inputs are correlated with the times at which the inputs were received, a sensed posture state of the patient, and a therapy program defining therapy delivery at each of the times the posture state was sensed. Posture-responsive therapy is adjusted based on the historical posture-responsive therapy information correlating the patient input, patient input time, sensed posture state, and therapy program.11-04-2010
20110190692VASODILATOR DELIVERY REGULATED BY BLOOD PRESSURE OR BLOOD FLOW - The effectiveness of a vasodilator delivered to a patient and/or the operation of the fluid delivery device from which the vasodilator is delivered are evaluated based on feedback from one or more sensors implanted within the patient. A fluid delivery system includes a fluid delivery device, a sensor, and a processor. The fluid delivery device is configured to deliver a vasodilator. The sensor is configured to sense at least one of blood pressure or blood flow in one of a ventricle or an atria of a heart, a pulmonary artery, and a renal vessel. The processor is configured to trigger a therapeutic action when the sensed at least one of blood pressure or blood flow traverses the threshold.08-04-2011
20100030137APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES - An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength λ. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.02-04-2010
20110218489Method and System for Providing Sensor Redundancy - A closed loop system or semi-closed loop system for infusing insulin using sensor values applies a redundant sensor system as a fail-safe method against sensor failure. The redundant glucose sensors are used corroborate each other and a failing sensor is detected if the sensors no longer corroborate each other. The use of redundant sensors has the additional benefit of producing better sensor signals compared to the use of a single sensor.09-08-2011
20100016788Analyte Meter Protectors and Methods - Analyte meter protectors, meters that include the same, and methods.01-21-2010
20090118666Method and implantable device for measuring hematocrit - In a method for detecting a change of a condition of a patient using an implantable medical device being connectable to the patient in at least one electrode configuration, at least one impedance measurement session is initiated to obtain at least one impedance value corresponding to an impedance of whole blood of the patient. At least one relative or absolute value of an amount of hematocrit in the blood of the patient is calculated using the at least one impedance value. A present hematocrit level is determined dependent on the at least one hematocrit value, with a change of the condition being derived from the present hematocrit level of the patient.05-07-2009
20120046606Integrated glucose monitor and insulin injection pen with automatic emergency notification - A portable insulin injection pen and blood glucose monitoring device is integrated into a single unit for testing and treating diabetes symptoms. The device has a housing of a size suitable for transport in a user's clothing pocket or handbag. Within the housing is a blood glucose monitoring system for receiving a sample of the user's blood and detecting its glucose level, an insulin injection mechanism for administering an insulin injection, and a microprocessor that calculates an insulin dosage appropriate to the detected blood glucose level and sets the insulin injection mechanism to administer the calculated insulin dosage. A communication device automatically informs a remote emergency service provider, such as 911 or an emergency service to which the user has subscribed, if the microprocessor determines that the detected blood glucose level presents a potential danger to the user. The microprocessor also calculates treatment regimens specific to a particular user based on the detected blood glucose level and displays the treatment regimens on an LCD display. In a particularly advantageous embodiment, a GPS receiver within the housing detects the location of the device, and the communication device, which can be a cellular telephone separate from the housing connected wirelessly to the unit via a Bluetooth connection or cellular telephone circuitry within the housing itself, transmits information regarding the location to the remote emergency service.02-23-2012
20120109048PROTOCOL IMPLEMENTATION FOR TELEMETRY COMMUNICATIONS INVOLVING IMPLANTABLE MEDICAL DEVICES - Embodiments of the invention relate to optimizing telemetry communication involving one or more medical devices and one or more electrical devices. The telemetry communication is optimized by implementing software and/or one or more additional circuits within at least one medical device and at least one electrical device to provide one or more modes or functions of optimizing transfer of data between the medical device and the at least one electrical device, minimizing interference of the data transfer, and reducing data transfer time and/or preserving electrical energy sources of one or more of the medical device and the at least one electrical device.05-03-2012
20100298764Fluid delivery system with optical sensing of analyte concentration levels - A system for continuous monitoring of body analytes and controlling delivery of fluids to a body of a user. The system includes a sensing apparatus configured to detect concentration level of analyte in the body of the user using optical means and a dispensing apparatus configured to infuse fluid into the body of the user based on the detected concentration level of analyte.11-25-2010
20120310152SYSTEM AND METHOD FOR CONFIGURING A RULE SET FOR MEDICAL EVENT MANAGEMENT AND RESPONSES - A system and method to configure a rule set used in connection with a medical monitoring system for monitoring patients and patient care equipment, especially medication delivery pumps, based on a variety of conditions and parameters associated with monitored biometric information and equipment information and for providing user-defined responses to those conditions and parameters.12-06-2012
20120010562INFUSION DEVICE - An infusion system that includes a controller device and a communication system to provide for two-way communication between the controller device and an infusion device that controls delivery of fluids to a user's body. Either the controller device or the infusion device may be integrated with a characteristic determining device in a single housing. The housing, in turn, may include a test-strip receptacle and an illuminator disposed so as to illuminate an area covering the receptacle and a test-strip inserted therein. The illuminator may be configured to be activated automatically when a test strip is inserted into the receptacle, selectively by the user via a button, key, or similar mechanism, and/or when the ambient light level, measured, e.g., with a light sensor, falls below a predetermined intensity. The illuminator may be a LED emitting white light, and may provide illumination at various levels of intensity.01-12-2012
20120016295PUMP INFUSION SYSTEM - In a pump infusion system comprising a pump adapted to be attached to a user and to cause infusion of pharmaceutical substances into the user's body, questions regarding the effects of administration of the pharmaceutical substances are provided, answers to said questions are transmitted to an attending staff, said answers are recorded, and said pump is controlled so as to adjust the dose of the pharmaceutical substances in accordance with said answers. Further, for a safe remote programming of such a pump infusion system, a predetermined program is assigned, a protocol to be programmed is compared with a protocol coming from the pump, possible errors of non-medically certified intervening devices and means are eliminated, and the programming is executed.01-19-2012
20110092897Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.04-21-2011
20100137788METHODS AND SYSTEMS FOR DETERMINING AN INTRAVENOUS INSULIN INFUSION RATE TO CORRECT HYPERGLYCEMIA OF A PATIENT, TO MAINTAIN EUGLYCEMIA OF A PATIENT, AND TO PREVENT HYPOGLYCEMIA OF A PATIENT - Methods and systems for determining an intravenous infusion rate to correct hyperglycemia of a patient, to maintain euglycemia of a patient, and to prevent hypoglycemia are disclosed. In one aspect, a method for determining an intravenous insulin infusion rate to correct hyperglycemia of a patient includes estimating an insulin infusion maintenance rate to maintain euglycemia in a patient. Further, a relationship between a current blood glucose concentration of the patient and a target blood glucose concentration may be determined. An insulin infusion rate may be determined based on the estimated insulin infusion maintenance rate and based on the relationship between the current blood glucose concentration and the target blood glucose concentration. A glycemic response of the patient may be measured while using the determined insulin infusion rate. The insulin infusion maintenance rate is re-estimated based on the glycemic response of the patient at a previous insulin infusion rate.06-03-2010
20100094204ACS THERAPY SYSTEM - An ACS therapy system for continuously monitoring Intra-Abdominal Pressure (IAP) and preventing the onset of ACS. The automated ACS therapy system includes a urine withdrawal device, an IAP regulation circuit, an IAP monitor connected to the urine withdrawal device to supply an IAP value to the IAP regulation circuit, and an abdominal fluid removal device The abdominal fluid removal device may be connected to an active suction device, which withdraws fluid from the abdominal cavity through the abdominal fluid removal device when activated by the IAP regulation circuit. Based on the IAP value, the IAP regulation circuit may send a control signal that controls the active suction device to turn on and drain fluid from the abdominal cavity. When the IAP value reaches certain levels, the IAP regulation circuit may cause the active suction device to be turned off.04-15-2010
20100094203Special purpose fluid dispenser - A compact, nonelectric fluid dispenser for use in controllably dispensing beneficial agents such as propofol and dexmedetomidine hydrochloride to patients. The dispenser includes a fluid flow control assembly that precisely controls the flow of the medicament solution to the patient and embodies a collapsible drug container that can be filled in the field with the beneficial agents to be delivered to the patient. The unit-dose fluid dispenser of the invention is presented in a sterile and aseptic manner, where the drug has been pre-filled in the system, so that the practitioner cannot mistakenly give the wrong drug to the patient. The dispenser uniquely provides a more efficient medicament delivery system for procedure rooms, such as the endoscopy center, so that a greater number of patients can be treated per day at a higher standard of care with increased profits for the healthcare provider.04-15-2010
20100241064 Automatic Anaesthesia Delivery System - This invention relates to an improved automatic anaesthesia delivery system comprising: (a) at least one of a bispectral index monitor and an anaesthesia vital sign monitor interfaced with a computer to receive input from patient; (b) at least one pump for controlling delivery of drug based on the feedback from patient; (c) said computer having specific software for controlling said pump(s) and for fine tuning the dosage based on patient's response and requirements.09-23-2010
20100241063Liquid Flow Sensing System - A liquid flow sensing system comprises a pump system configured to deliver a pre-determined volume V of liquid, and a measuring system comprising a chamber connected to the pump system and to an outlet system, the chamber bounded by an elastic membrane configured to be displaced elastically by an amplitude that enables said pre-determined volume V of liquid to be injected in the chamber. The measuring system further comprises a membrane displacement sensor configured to measure at least a portion of a decay characteristic of said membrane displacement amplitude after injection of the pre-determined volume V, into a value that may be used for determining absolute or relative viscosity of the liquid or changes in flow resistance downstream of the sensing system or for determining the presence of gas bubbles in a liquid flow circuit.09-23-2010
20090131861FLUID COMPONENT ANALYSIS SYSTEM AND METHOD FOR GLUCOSE MONITORING AND CONTROL - Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g. insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.05-21-2009
20120220928System for Providing Blood Glucose Measurements to an Infusion Device - An infusion system includes a characteristic determining device and an infusion device. The characteristic determining device includes a receptacle for receiving and testing an analyte from the user to determine a concentration of the analyte in the user. The characteristic determining device also includes a communication system for transmitting a communication including data indicative of the determined concentration of the analyte in the user, and the infusion device includes a communication system for receiving the communication from the characteristic determining device. The infusion device further includes a bolus estimator for calculating an estimated amount of fluid to be infused into the body of the user based upon the received data indicative of the determined concentration of the analyte in the user and a target concentration of the analyte in the user, and an indicator to indicate when the estimated amount of fluid to be infused has been calculated.08-30-2012
20120136297ENTERAL FEEDING APPARATUS - Embodiments of the present invention include a enteral feeding apparatus and/or system in which an enteral feeding pump can be configured to deliver enteral formula to a patient in accordance with a delivery parameter determined using patient information associated with a patient to be treated and formula information associated with an enteral formula to be delivered to the patient. Exemplary embodiments can determine an estimated daily caloric intake for a patient and can configure the enteral feeding pump to satisfy the caloric requirements of the patient. Exemplary embodiments are also able to monitor the delivery of the enteral formula to ensure that the patient is being properly treated.05-31-2012
20110184343DRUG DELIVERY WITH EVENT NOTIFICATION - Devices, systems and methods are provided for drug delivery and the monitoring thereof.07-28-2011
20100174228Hypoglycemia prediction and control - A system for predicting hypoglycemia based on continuous blood glucose monitor values is provided. The hypoglycemia detection algorithm is a set of individual alarms that are combined through a voting system into one combined alarm. The system could have five components and an overall voting algorithm that produces a binary alarm outcome depending on the number of constituent algorithms that report an alarm. A controller system automatically shuts off the insulin pump when pending or real hypoglycemia has been reached. The algorithms operate in a closed loop and automatically take action when the subject is asleep.07-08-2010
20130172808MEDICAL INFUSION DEVICE PRODUCING ADENOSINE TRIPHOSPHATE FROM CARBOHYDRATES - A medical infusion system which increases adenosine triphosphate from carbohydrates by a pump delivering precisely timed and calculated boluses of hormones such as insulin resulting in oscillations of hormones in whole blood sufficient to cover a carbohydrate load equal to no less than forty percent (40%) of the minimum daily allowance for carbohydrates where the blood glucose is from 60 mg/dl to 300 mg/dl. The system comprises a pump and optimally a cassette or cartridge where the plunger rotates as it advances in reference to the cartridge to provide additional accuracy and overcome the forces of inertia and slip-stick as well as eliminate backlash. The system can also use an encoded area and an opening for connection to an infusion tube with an in-line sensor area where sampling probes can be located to optimized adenosine triphosphate production from the mitochondria in the cells.07-04-2013
20120172792OBESITY THERAPY AND HEART RATE VARIABILITY - Methods and devices are provided for delivering obesity therapy to a patient. In general, the methods and devices allow for onset of a patient eating solid food, e.g., the patient beginning a meal, to trigger delivery of an obesity therapy to a patient. The obesity therapy can be delivered to the patient for a limited period of time such that the patient stops receiving the obesity therapy prior to a second onset of the patient eating solid food, e.g., the patient beginning a second meal, which can trigger a second delivery of the obesity therapy to the patient for a limited period of time.07-05-2012
20100049120DESIGN OF SWALLOWABLE MULTI-NOZZLE DOSING DEVICE FOR RELEASING MEDICINES IN THE GASTROINTESTINAL TRACT - A capsule and methodology for dispensing a medicament in the gastrointestinal tract of a mammal is disclosed, the gastrointestinal tract having tissue sites of interest. The capsule may include a medicament reservoir; medicament dispensing means such as a plurality of piezoelectric droplet jet nozzle dispensers; a power source; electronic control circuitry means and/or detecting means capable of communicating with a medicament dispensing means for regulating the amount and time interval for dispensing of the medicament into the gastrointestinal tract by the medicament dispensing means; and a non-digestible outer protective shell housing, e.g., the medicament reservoir, medicament dispensing means and electronic control circuitry means. A plurality of the nozzle dispensers of the medicament dispensing means can be positioned tangentially to a surface of the housing such that during release of a medicament, the capsule is caused to rotate and/or translate so as to discharge the medicament homogeneously onto tissue sites of interest. In addition, by using multiple nozzles and releasing medicament at high speed, this facilitates medicament absorption by the intestines in the gastrointestinal tract.02-25-2010
20120179093SYSTEM AND METHOD FOR CLOSED-LOOP PATIENT-ADAPTIVE HEMODYNAMIC MANAGEMENT - A system and method for patient-adaptive hemodynamic management is described. One embodiment includes a system for hemodynamic management including transfusion, volume resuscitation with intravenous fluids, and medications, utilizing monitored hemodynamic parameters including the described dynamic predictors of fluid responsiveness, and including an intelligent algorithm capable of adaptation of the function of the device to specific patients.07-12-2012
20100010432ASSOCIATING THERAPY ADJUSTMENTS WITH PATIENT POSTURE STATES - A therapy adjustment received from a patient is associated with a sensed patient posture state. Thereafter, a stability indication can be associated with the sensed posture state to indicate that a therapy adjustment specific to the sensed posture state was received and implemented. In addition, therapy parameter values associated with related patient posture states are updated based on the therapy adjustment. In some examples, only the related posture states that are not associated with respective stability indications are updated based on the therapy adjustment. The absence of a stability indication indicates that the patient has not inputted a therapy adjustment specific to the respective related posture state. As a result, the therapy parameter values associated with the related posture states that are not associated with stability indications may float until the patient adjusts the therapy parameter value associated with the respective related posture state.01-14-2010
20100010433MEDICAL SYSTEM WHICH CONTROLS DELIVERY OF A DRUG - A first medical system includes a controller, a plurality of predetermined patient monitors, and a predetermined drug-delivering medical effector. The controller is adapted to choose different groups of the patient monitors for different medical procedures involving the medical effector. A second medical system includes a controller which is adapted to identify, by querying, connected ones of a multiplicity of medical effectors and connected ones of a plurality of patient monitors and is adapted to control at least one connected medical effector using at least some of the connected patient monitors for a predetermined medical procedure.01-14-2010
20120259278Algorithm Sensor Augmented Bolus Estimator for Semi-Closed Loop Infusion System - An infusion system is for infusing a fluid into the body of a patient. The infusion system includes at least one sensor for monitoring blood glucose concentration of the patient and an infusion device for delivering fluid to the patient. The sensor produces at least one sensor signal input. The infusion device uses the at least one sensor signal input and a derivative predicted algorithm to determine future blood glucose levels. The infusion device delivers fluid to the patient when future blood glucose levels are in a patient's target range. The infusion device is capable of suspending and resuming fluid delivery based on future blood glucose levels and a patient's low shutoff threshold. The infusion device suspends fluid delivery when future blood glucose levels falls below the low shutoff threshold. The infusion device resumes fluid delivery when a future blood glucose level is above the low shutoff threshold.10-11-2012
20080300534INSULIN PUMP BASED EXPERT SYSTEM - An apparatus comprising a pump configured to deliver insulin, an input configured to receive blood glucose data, a user interface, and a controller communicatively coupled to the pump, the input, and the user interface. The controller includes a blood glucose data module to compare the blood glucose data to a target blood glucose level for an insulin pump user. The controller is configured to present a question related to the blood glucose level via the user interface when the blood glucose level is different than the target blood glucose level, receive a response to the question via the user interface, and present a recommended user action based at least in part on the response. Other devices, systems, and methods are disclosed.12-04-2008
20100168659Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.07-01-2010
20120265126Infusion Pump Systems and Methods - Some embodiments an infusion pump system can be used to determine a user's total insulin load (TIL) that provides an accurate indication of the insulin previously delivered to the user's body which has not yet acted. In particular embodiments, the TIL can account for both the bolus deliveries and the basal deliveries that have occurred over a period of time. Such information may be useful, for example, when the infusion pump is operated in conjunction with a continuous glucose monitoring device.10-18-2012
20120265125Infusion Pump System - There is provided an infusion pump system for delivering a predetermined medical solution at a preset reference infusion speed. The system comprises a medical solution container; an infusion line through which the medical solution is drawn out of the medical solution container; an infusion pump configured to discharge the medical solution via the infusion line. The infusion pump is controlled so that the discharge speed of the infusion pump is computed on the basis of a current discharge speed of the infusion pump and the infusion speed of the medical solution, the resulting discharge speed is corrected by a predefined correction coefficient, and the medical solution is discharged at the corrected discharge speed.10-18-2012
20110238005FLUID INJECTION SYSTEM - A fluid injection system includes: a first apparatus which is attached to a human body and injects a fluid into the human body; and a second apparatus which is attached to a wrist of the human body and remotely controls the first apparatus, wherein the second apparatus includes an entry section accepting an entry of an operation command to the first apparatus and a first communicating section transmitting the operation command to the first apparatus, and the first apparatus includes a second communicating section receiving the operation command, a storing section storing the fluid, and a transporting section transporting the fluid from the storing section and injecting the fluid into the human body based on the operation command.09-29-2011
20100234797Patient hydration system with bolus function - A patient hydration system including an infusion device for administering hydration fluid to a patient, and a hydration fluid measurement device responsive to a source of hydration fluid, a patient urine output measurement device. A controller is responsive to the hydration fluid measurement device and the patient urine output measurement device. The controller operates the infusion device, in response to the patient urine output measurement device and the hydration fluid measurement device, to hydrate the patient based on the patient's urine output. The controller also monitors the operation history of the infusion device thereby providing redundancy in the measurement of the amount of hydration fluid administered to the patient.09-16-2010
20100234796SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA - Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.09-16-2010
20120277668SELECTIVE ALARMS FOR AN INFUSION DEVICE - An infusion system to administer a fluid includes an infusion pump with a pump processor, a pump memory to store a plurality of configurable alarms and a pump radio to enable bi-directional communication. The infusion system further includes a controller that has a controller processor, a controller memory, a controller radio to transmit and receive communication from the pump radio. The controller further has a graphical user interface shown on a display along with controls to manipulate the graphical user interface. Furthermore, the bi-directional communication between the infusion pump and the controller establish an infusion pump relative proximity between the infusion pump and the controller such that when the infusion pump relative proximity exceeds a pump threshold distance at least one of the plurality of configurable alarm conditions of the infusion pump is modified.11-01-2012
20100168657SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA - Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.07-01-2010
20100168660Method and apparatus for determining and delivering a drug bolus - An electronic device may be configured to prompt a user via an on-board display to measure user glucose via an on-board glucose meter, to compute a first drug bolus value based on the measured user glucose, to display the first drug bolus value on the display and prompt the user via the display to enter carbohydrate information into the device, to compute a second drug bolus value based on the entered carbohydrate information, to display the second drug bolus value on the display and prompt the user via the display to enter user health information into the device, to compute a third drug bolus value based on the entered health information and a total drug bolus value as a sum of the first, second and third drug bolus values, and to display the third and total drug bolus values on the display.07-01-2010
20110295196SYSTEM FOR CONTROLLING MEANS FOR INJECTION OF ANESTHETICS OR SEDATIVES - A system comprising means for obtaining a signal representative of the electrocortical activity of the patient, means for analyzing this signal in order to derive from it a signal of depth of anaesthesia, means for monitoring the value and development over time of this signal of depth of anaesthesia, these means being associated with means for calculation of control commands of the injection means, in order to regulate automatically in closed loop the signal of depth of anaesthesia in a predetermined range around a target value, and in that the means for injection of anaesthetics comprise first means for injection of a hypnotic that receive control commands at a first frequency, and second means for injection of a morphinomimetic that receive control commands at a second frequency higher than the first frequency.12-01-2011
20110319813INFUSION PUMP APPARATUS, METHOD AND SYSTEM - An infusion pump system is disclosed. The infusion pump system includes an infusion pump and a controller device in wireless communication with the infusion pump, wherein the controller including instructions for controlling the infusion pump, wherein the instructions may be synchronized with a secure web portal.12-29-2011
20120330227INTEGRATED INSULIN DELIVERY SYSTEM HAVING DELIVERY SAFETY FEATURES - An integrated insulin delivery system having safety features for controlling medication delivery includes automatic resumption of basal rate after a particular event, such as termination of a bolus, expiration of a time period, delayed resumption after the bolus has terminated, IOB comparison, and others. Other safety features include overriding a delivery control that may result in hypoglycemia, terminating an extended bolus or temporary basal rate in view of a glucose signal indicating imminent carbohydrate deficiency, and controlling the delivery rate to take an asymmetrical bias range of a glucose sensor into account to avoid hypoglycemia.12-27-2012
20120101430Body-Associated Receiver and Method - Receivers, which may be external or implantable, are provided. Aspects of receivers of the invention include the presence of one or more of: a high power-low power module; an intermediary module; a power supply module configured to activate and deactivate one or more power supplies to a high power processing block; a serial peripheral interface bus connecting master and slave blocks; and a multi-purpose connector. Receivers of the invention may be configured to receive a conductively transmitted signal. Also provided are systems that include the receivers, as well as methods of using the same. Additionally systems and methods are disclosed for using a receiver for coordinating with dosage delivery systems.04-26-2012
20090062728Control of Body Fluid Condition Using Diuretics, Based on Weight Measurement - The system for controlling body fluids overcomes the limitations of the prior art by automatically infusing diuretic and/or other drugs into a human patient. In one approach, the rate of infusion of the diuretic is adjusted based on the measured weight of the patient. For example, this weight can be transmitted wirelessly to a portable diuretic infusion device attached to the patient.03-05-2009
20100168661DRUG DELIVERY WITH EVENT NOTIFICATION - Devices, systems and methods are provided for drug delivery and the monitoring thereof.07-01-2010
20110160653INFUSION PUMP INCLUDING PAIN CONTROLLED ANALGESIC ("PCA") APPARATUS - An infusion pump includes: a housing, a pump actuator supported by the housing, electronics configured to control the pump actuator, a pain controlled analgesic (“PCA”) input device, a cord having a remote end connected to the PCA input device and a local end connected to the housing, a remote integrated circuit; and a local integrated circuit in communication with the electronics and the remote integrated circuit so as to provide operational information concerning the PCA input device to the electronics.06-30-2011
20110160652MODULAR SKIN-ADHERABLE SYSTEM FOR MEDICAL FLUID DELIVERY - Disclosed is a portable therapeutic fluid dispensing device. The fluid dispensing device includes a reusable part (06-30-2011
20130023819System and method for monitoring at least one blood parameter - The invention relates to a system and a method for monitoring at least one blood parameter of the blood from a predetermined patient, with an access device for setting up access to the patient's blood, a removal device for removing an amount of blood in order to obtain a blood sample, a blood analysis device for analysing the blood sample, and a calculation device for calculating drug parameters of a drug to be administered to the patient as well as a supply device for supplying the drug having the calculated drug parameters. The system identifies the blood samples using bar codes, as a result of which there are no errors when assigning the blood to be analysed to the respective patient.01-24-2013
20080228133DELIVERY OF A SYMPATHOLYTIC CARDIOVASCULAR AGENT TO THE CENTRAL NERVOUS SYSTEM - A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine).09-18-2008
20130178791Method and system for detecting and treating biological and chemical warfare agents - The present invention generally relates to radio-enabled devices for detection and remedy of biological and chemical warfare attack. More particularly, this invention relates to an on-body apparatus that provides a means of treatment which is innocuous to the wearer, but capable of injecting antidotes within seconds and preferably also combines multiple means of sensing chemical and biological agents as well as monitoring user's physiological response to the antidotes thereby to enable tailored and continuous infusion of antidotes while minimizing the side effect of the antidotes themselves. A key embodiment of this invention is the incorporation of an electronically-controlled needle or cannula that will deploy only when commanded to. When not deployed, the device sits inertly against the patient's skin, affixed by adhesive and or elastic materials.07-11-2013
20130144206Medical Device With Contextual Awareness - A medical device, such as an infusion pump, obtains a contextual awareness of its operation by communicating with centralized patient records and or other medical equipment communicating with a common patient, and/or provides real time advisory information, at care point or remotely. A protocol obtained by the medical device from a protocol server provides context-aware protocols and necessary predicate information for those protocols. This predicate information may be discovered by the medical device communicating with electronic medical records and the associated medical equipment.06-06-2013
20080294096Delivery of Agents Such as Cells to Tissue - A system for delivering a fluid comprising cells to tissue of a patient, includes: a least a first container for holding an injection fluid in which the agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system; and a communication system in connection with at least the control system and the sensor system. The communication system is adapted to provide information to the control system. The control system in adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system. The cells can for example be pregenitor cells or stem cells.11-27-2008
20130102957CONTROLLED NEEDLE-FREE TRANSPORT - A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.04-25-2013
20110218490ANALYTE MONITORING SENSOR SYSTEM FOR MONITORING A CONSTITUENT IN BODY TISSUE - The invention generally relates to a sensor system. In particular to a sensor for glucose monitoring. The invention also also relates to an arrangement and a method for monitoring a constituent and in particular glucose in body tissue using a sensor system.09-08-2011
20100286601MAINTAINING GLYCEMIC CONTROL DURING EXERCISE - Devices, apparatuses and methods for controlling blood-glucose levels during exercise are described. For example, an insulin infusion apparatus can include a control module to regulate a rate of therapeutic fluid release into a body of a patient based on a determined therapeutic fluid requirement profile, and a dispensing unit to release therapeutic fluid at the regulated rate. The methods and devices can be implemented by receiving a first value corresponding to a first glucose concentration before an exercise activity of a user; receiving a second value corresponding to a second glucose concentration after the exercise activity for the user; determining a glucose concentration change based on a difference between the second value and the first value; modifying a basal rate based on a comparison of the glucose concentration change with a predetermined threshold value; and, recording the modified basal rate in a computer-readable memory device.11-11-2010
20100286600TRANSDERMAL PATCH DEVICE - A patch device worn by a user is disclosed that is configured to sense the presence of a harmful substance in the environment and to deliver an antidote to that substance into the user without the intervention of the user. The patch device incorporates a sensing mechanism configured to sense a presence of the harmful substance in the environment surrounding the patch device. On sensing the presence of the harmful substance, the sensor triggers a delivery mechanism, which causes the therapeutic agent to be injected into the user. The therapeutic agent acts to antidote the effects of the harmful substance within the user. The patch device could be used for protection against exposure to substances such as nerve gas and pesticides. The patch could be used to deliver the therapeutic agent either subcutaneously or transdermally.11-11-2010
20110275985MAGNETIC NANOSENSOR COMPOSITIONS AND BIOANALYTICAL ASSAYS THEREFOR - Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.11-10-2011
20120277669BLOOD SUGAR LEVEL CONTROL SYSTEM - A blood sugar level control system for measuring a blood sugar level and administering insulin into a body. The blood sugar level control system includes a blood sugar measuring device having a first wireless data transmitting part to transmit data relating to the blood sugar level; an insulin dispensing device having a wireless data communication unit including a second wireless data transmitting part to transmit data to a second blood sugar measuring device, and a wireless data receiving part to receive data from the first wireless data transmitting part and the second blood sugar measuring device; and an attachment mechanism to couple the insulin dispensing device and the blood sugar measuring device so that the blood sugar measuring device is movable, without separating from the insulin dispensing device at least three specific positions.11-01-2012
20100292634SYSTEM, METHOD AND ARTICLE FOR CONTROLLING THE DISPENSING OF INSULIN - A system and method for automatically adjusting parameters for predicting blood glucose levels and/or controlling the dispensing of insulin. In one embodiment, the system is a stand-alone system. In one embodiment, the system is part of a system for controlling the dispensing of insulin.11-18-2010
20120283631Burn Patient Resuscitation System - A system for operating a semi-closed loop and/or a closed loop resuscitation of a burn patient in view of patient information and other physiological data gathered by the system. The system in at least one embodiment includes an urine sensor, an infusion pump and a processor that controls the operation of the infusion pump at least in part from a signal received from the urine sensor.11-08-2012
20130158473APPARATUS AND METHOD FOR CONTROLLING INSULIN INFUSION WITH STATE VARIABLE FEEDBACK - An infusion system, which may be a closed loop infusion system or “semi-closed-loop” system, uses state variable feedback to control the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The “semi-closed-loop” system further includes prompts that are displayed or sounded or otherwise provide indications to the user prior to fluid delivery. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The delivery system infuses a fluid into the user at a rate dictated by the commands from the controller. The system may use three state variables, subcutaneous insulin concentration, plasma insulin concentration, and insulin effect, and corresponding gains, to calculate an additional amount of fluid to be infused as a bolus and to be removed from the basal delivery of the fluid.06-20-2013
20130184639TREATMENT OF MOOD AND/OR ANXIETY DISORDERS BY ELECTRICAL BRAIN STIMULATION AND/OR DRUG INFUSION - A system and method for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to treat mood and/or anxiety disorders uses an implantable system control unit (SCU), specifically an implantable signal/pulse generator (IPG) or microstimulator with one or more electrodes in the case of electrical stimulation, and an implantable pump with one or more catheters in the case of drug infusion. In cases requiring both electrical and drug stimulation, one or more SCUs are used. Alternatively and preferably, when needed, an SCU provides both electrical stimulation and one or more stimulating drugs. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters.07-18-2013
20130197430MONITORING AND DELIVERY SYSTEM FOR SUPPLYING PATIENT WITH CONTROLLED DOSAGE OF SUBSTANCE REVERSAL AGENT - The present disclosure involves a system for monitoring patients, and more specifically post-operative patients receiving narcotics/sedatives/opioids, and a novel apparatus for automatically delivering one or more substances such as a reversing agent, including but not limited to the agent commonly known as naloxone, in response to dangerous respiratory conditions such as respiratory depression or other undesired consequences caused by reaction to another dosage being delivered to the subject.08-01-2013
20120095393USE OF A HANDHELD MEDICAL DEVICE AS A COMMUNICATIONS MEDIATOR BETWEEN A PERSONAL COMPUTER-BASED CONFIGURATOR AND ANOTHER NETWORKED MEDICAL DEVICE - A handheld diabetes managing device that provides a secure and efficient communication link between an insulin pump and an external computing device. The handheld diabetes managing device can include a blood glucose meter, a processor and first and second communication modules. The handheld diabetes managing device can be configured to deliver data between an insulin pump and an external computing device over a secure communication path without a direct communication link between the insulin pump and the external computing device. The secure communication path can include a first secure bidirectional communication link between the handheld diabetes managing device and the insulin pump and a second secure bidirectional communication link between the handheld diabetes managing device and the external computing device.04-19-2012

Patent applications in class Sensor responsive to body condition