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By catheter

Subclass of:

604 - Surgery


604048000 - Treating material introduced into or removed from body orifice, or inserted or removed subcutaneously other than by diffusing through skin

604500000 - Method

604506000 - Therapeutic material introduced or removed through a piercing conduit (e.g., trocar) inserted into body

604507000 - Therapeutic material introduced into or removed from vasculature

Patent class list (only not empty are listed)

Deeper subclasses:

Class / Patent application numberDescriptionNumber of patent applications / Date published
604509000 With expanding member (i.e., balloon) 130
604510000 With associated advancing or guiding means 31
20100160896Blood Flow Bypass Catheters and Methods for the Delivery of Medium to the Vasculature and Body Ducts - A catheterization device that may be designed by use of an adaptive genetic algorithm computational fluid dynamics approach, as well as other Global Optimization methods that may include simulated annealing, multistart and interval methods, continuous branch and bound methods, evolutionary algorithms, and tabu search and scatter search methods, as well as other available Global Optimization methods that is able to maximize/optimize the dwell time of an infused agent in the vicinity of a vascular lesion. The device may have an internal by-pass channel that allows the blood upstream of the lesion to continue its pulsatile flow through the vessel in the part of it occluded by the lesion, while simultaneously allowing the disbursement and maximal dwell time of an antithrombolytic or other diagnostic or therapeutic agent needed to treat the lesion. Different embodiments of the catheterization device are disclosed and indications for the use of these devices in the treatment of vascular diseases are discussed.06-24-2010
20090018525Tapered catheter devices - Catheters, catheter systems, and methods of using catheters to deliver therapy are disclosed. Advantages include increased torqueability and control with catheters, having a soft distal tip. Catheter systems including a sheath and catheter are disclosed wherein the catheter fits the sheath with a dilator-like fit.01-15-2009
20100114063CATHETER INJECTION MONITORING DEVICE - A catheter is provided that has at least one lumen which extends from a proximal end of the catheter to a distal end of the catheter. The catheter also has a catheter hub that has a body with a proximal end, a distal end, an exterior surface, and defining an interior cavity. The exterior surface of the body further defines at least one opening. At least one opening is defined therein the proximal end, and at least one opening is defined therein the distal end. The catheter also has a means for measuring and displaying the number of times that the catheter is injected with an infusate at a pre-determined pressure.05-06-2010
20100114064MITIGATION OF CONTRAST-INDUCED NEPHROPATHY - A system, includes a pressurizing mechanism to pressurize a fluid including a contrast enhancement agent for delivery to a patient; and a control system in operative connection with the pressurizing mechanism. The control system includes a system to adjust control of fluid injection based upon a measurement of renal function of the patient.05-06-2010
20100145306Various Catheter Devices for Myocardial Injections or Other Uses - A catheter device comprising a proboscis shaft and a proboscis disposed within the proboscis shaft. In certain embodiments, the catheter device further comprises an elongate tubular member, wherein the proboscis shaft is disposed within the elongate tubular member. In certain embodiments, the catheter device comprises a tissue surface engagement structure, which has a first configuration and a second configuration. In the second configuration, the tissue surface engagement structure presents a larger transverse profile in comparison to the first configuration. The tissue surface engagement structure may have any of various designs, including an expandable assembly and a hinged assembly. In certain embodiments, a deformable cushion is positioned at the distal end of the proboscis shaft. The deformable cushion comprises a pocket that is filled with a reshapeable material. In certain embodiments, the proboscis shaft comprises a longitudinally compressible portion.06-10-2010
20130041348Catheter-Based Delivery of Skeletal Myoblasts to the Myocardium of Damaged Hearts - The present invention provides improved systems and methods for the minimally invasive treatment of heart tissue deficiency, damage and/or loss, especially in patients suffering from disorders characterized by insufficient cardiac function, such as congestive heart failure or myocardial infarction. In certain embodiments, a cell composition comprising autologous skeletal myoblasts and, optionally, fibroblasts, cardiomyocytes and/or stem cells, is delivered to a subject's myocardium at or near the site of tissue deficiency, damage or loss, using an intravascular catheter with a deployable needle. Preferably, the cell transplantation is performed after identifying a region of the subject's myocardium in need of treatment. The inventive procedure, which can be repeated several times over time, results in improved structural and/or functional properties of the region treated, as well as in improved overall cardiac function. In particular, the inventive therapeutic methods may be performed on patients that have previously undergone CABG or LVAD implantation.02-14-2013
20090076480Active Ingredient-Containing Silicone Elastomers - The invention relates to compositions comprising silicone elastomers and antimicrobially active substances in homogeneous distribution, a process for their production and their use in medical articles.03-19-2009
20100106135ANGIOCATHETER AND METHOD OF OPERATING THE SAME - An improved angiocatheter device for introducing intravenous fluids or drugs into the lumen of a patient through a sheath. At the point of the procedure where a needle needs to be removed but the sheath is to remain implanted, a spring in the needle portion of the device is expanded thereby retracting the needle and allowing the operator to remove the needle from the sheath and an introducer hub. This feature allows for quick insertion and removal from the patient without the necessity of sliding or otherwise removing the needle from the sheath in a multiple step process. In this manner, the catheter or lead can implanted quickly and safely while also protecting the operator from accidental exposure to the patient's blood and eliminating the need to apply positive pressure to the lumen while the needle is being removed.04-29-2010
20120184940BIOARTIFICIAL KIDNEYS - The present invention generally relates to improved bioartificial kidneys (BAKs), and in certain embodiments to improved bioartificial kidneys that are portable and/or wearable by a user. In some embodiments, the BAKs may comprise an ultrafiltration unit and a reabsorption unit. The reabsorption unit may contain a reabsorption membrane having a layer of renal proximal tubule cells disposed thereon, where the renal proximal tubule cells selectively allow solutes to pass through the reabsorption membrane. In some embodiments, at least the reabsorption unit may be configured as a substantially flat-plate filtration device, which can impart advantageous properties such as improved maintenance of the renal proximal tubule cell layer, more facile monitoring of the renal proximal tubule cell layer as well as enhanced profile for wearability.07-19-2012
20120184939TUBING SET HAVING AN INSERT FOR THE INFUSION OF DRUGS - The present invention refers to a tubing set (07-19-2012
20120165785Catheter System for a Needle Injector with an Automatic Needle/Barrier Extension - A catheter system includes a positioning catheter for receiving an injection needle into its lumen. The injection needle incorporates a web member mounted directly onto its shaft. As the injection needle is moved in a distal direction to exit from the lumen of the catheter, the web member is biased to transition from a folded configuration, and into a flared configuration. Specifically, this transition occurs when the injection needle is deployed more than a predetermined distance “d” beyond the distal end of the catheter. In its flared configuration, the web member is disk-shaped and is oriented perpendicular to the needle. Thus, it acts as a barrier to limit the depth of insertion of the needle into target tissue of a patient, to a depth less than “d”, and to prevent perforation of the target tissue by the catheter tip.06-28-2012
20130046282Method Of Treating An Intravascular Site In A Patient, And Thrombolysis Catheter Therefor - A method of treating an intravascular site in a patient includes spraying jets of treatment fluid out of spray orifices formed in an elongate catheter body, and changing an impingement pattern of the treatment fluid on material within the intravascular site in response to a torque induced by a back pressure of the jets. A thrombolysis catheter includes an elongate catheter body having a plurality of spray orifices formed in a body wall, and communicating with a fluid lumen longitudinally extending in the elongate catheter body. The plurality of spray orifices define a torque inducing spray jet pattern, whereby a back pressure of spray jets exiting the spray orifices induces a torque on the elongate catheter body.02-21-2013
20110125131ENDOLUMINAL DELIVERY OF ANESTHESIA - Described herein are methods and devices for selectively applying fluids (particularly anesthetics) to a target tissue from within a blood vessel while minimizing the amount of fluid applied to non-target tissue. The injection catheters described herein may include an elongate body, a directional injector, and one or more holdfasts for securing the catheter before extending the injector. The methods of selectively applying anesthetic to a target structure generally include the steps of inserting an injection catheter into a body vessel, positioning the injection catheter within the body vessel near the target structure, anchoring the injection catheter before extending a directional injector from the injection catheter, and applying anesthetic from the injection catheter to the target structure.05-26-2011
20080294144Touch Sensing Catheter - A touch sensing catheter having a strain sensor assembly that may resolve the magnitude and direction of a force exerted on a distal extremity of the catheter, the strain sensor assembly being substantially insensitive to bulk temperature changes. A deformable structure having a plurality of optical fibers associated therewith that are strained by the imposition of a contact force transferred thereto. The optical fibers cooperate with the deformable structure to effect variable gap interferometers, such as Fabry-Perot resonators, that vary in operative length when a force is exerted on the deformable structure. The strain sensor assembly is rendered insensitive to bulk temperature changes by matching the coefficient of thermal expansion of the deformable body with that of the optical fibers. The strain sensor assembly may also be configured to mitigate the effects of thermal gradients using various thermal isolation techniques.11-27-2008
20090088724Multiple Stage Fluid Delivery Device and Method of Use - Multiple stage fluid delivery devices are provided for dispensing a first fluid at a first flow rate and thereafter dispensing a second fluid at a second flow rate which is substantially lower than the first flow rate. The device may be used to inject a fluid into a catheter to flush the catheter and to thereafter slowly deliver fluid into the catheter to maintain patency of the catheter.04-02-2009
20120035586Infusion Catheter And Method - An infusion catheter includes an elongate catheter body having a proximal body component and a distal body component. The distal body component includes a distal body outer surface and a distal body inner surface defining an infusion lumen. The distal body component further includes a skeleton, and a porous infusion control textile contacting the skeleton and extending circumferentially about a longitudinal axis of the catheter and defining a fluid emission profile thereof. The porous infusion control textile further includes a fiber network having a higher density space filling configuration at a proximal textile end and a lower density space filling configuration at a distal textile end, and defining a pressure sensitive flow rate property and a pressure insensitive flow distribution property of the fluid emission profile.02-09-2012
20120035585TAPERED VENOUS ACCESS INTRODUCER - A system and method for vessel catheterization is provided, having an introducer sheath and a catheter. The introducer sheath can include a handle and a sheath body extending from the handle. An access lumen is provided in the introducer sheath, and can include a tapered portion that is sized to receive a tapered outer surface of the catheter. The catheter may be a central venous catheter, such as a peripherally inserted central catheter, including a hub, a catheter body with at least one lumen extending distally from the hub, and at least one tube extending proximally from the hub. The introducer sheath is preferably a splittable sheath. The catheter can be inserted into the access lumen, and translated until confronting surfaces of the tapered outer surface of the catheter body and the tapered portion of the introducer sheath contact one another. This arrangement can inhibit buckling and/or kinking of the catheter during insertion, and improve initial catheter tip positioning.02-09-2012
20100100071SYSTEM AND METHOD FOR CONTROLLING FLUID PRESSURE DURING A MEDICAL INFUSION - A system for controlling an infusion of fluid into living tissue includes a catheter shaped to be introduced within living tissue and operable to deliver a fluid to a location within the living tissue, a fluid infusion pump mechanically coupled to the catheter and operable to pump fluid through the catheter and, thereby, into the location, the fluid infusion pump having at least two fluid pumping states, a fluid pressure monitor fluidically coupled to the catheter and operable to measure a pressure of the fluid within the catheter, and a processor communicatively coupled to the fluid infusion pump and the fluid pressure monitor, the processor operable to select between the at least two fluid pumping states based upon the measured pressure of the fluid within the catheter.04-22-2010
20090264858Catheter Having a Detachable Tip - A catheter is disclosed that has a detachable tip for delivery of a therapeutic substance to a chronic total occlusion (CTO) within a body vessel. The tip is made from a biodegradable material and includes an active agent dispersed therethrough. The detachable tip pierces into the calcified lesion, detaches from the catheter, and remains embedded within the lesion as the tip degrades, thereby releasing the active agent. The active agent is a therapeutic substance effective to treat of a CTO. The active agent may be a drug, an enzyme, bacteria, or a parasite that degrades or softens the calcified lesion.10-22-2009
20090275918PANCREATIC DELIVERY CATHETER - Pancreatic delivery catheters which facilitate direct intravascular access to the pancreas are described herein. A catheter which is configured particularly for pancreatic access may generally comprise a distal section which defines three curves each extending in an alternating pattern and a proximal section with an additional curve in an opposing direction. A primary curve defined along the distal section may define an acute angle with respect to a secondary curve and which also curves in an opposite direction. The secondary curve may define an acute angle with respect to both the primary curve and a tertiary curve which is proximal of the secondary curve. Similarly, a tertiary curve may extend in an opposite direction from the secondary curve. A quaternary curve along the proximal section may extend in an opposite direction from the tertiary curve.11-05-2009
20110208159Catheter Locking Composition - The present invention relates to locking compositions, kits containing the locking compositions and methods for maintaining the patency of vascular access devices or intravascular delivery devices employing the locking compositions. The locking compositions contain water, an anticoagulant and a viscosity agent and are free of heparin and alcohol.08-25-2011
20080287911CATHETER WITH LAMINAR FLOW DRUG DELIVERY PROPERTIES - Catheters with laminar flow bioactive agent delivery properties and methods of using for treating or preventing vascular disease are disclosed.11-20-2008
20080312636Systems and Methods for Needle Access to an Intervertebral Disc - A catheter with a balloon anchor may be sized to fit through an inner needle and introduced into the patient through the needle. The inner needle may comprise an atraumatic needle with a side port and/or a blunt tip. The catheter may include a radiopaque coil disposed over the distal portion of the catheter body to assist with catheter placement when viewed with fluoroscopy and/or x-ray. The distal portion of the catheter can be very flexible. A balloon inflation tube may terminate proximal to a proximal end of the expandable balloon anchor such that the distal portion of catheter can be flexible. This termination of the inflation tube may also position the inflation tube away from the annulus and nerve roots, so as to avoid irritation of the annulus and rubbing of the nerve roots that may potentially obscure FAD test results.12-18-2008
20120296312DEVICE AND METHOD FOR COMBINING A TREATMENT AGENT AND A GEL - A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.11-22-2012
20100137835DEPLOYMENT SYSTEM FOR MYOCARDIAL CELLULAR MATERIAL - A catheter-based deployment system for deploying cellular material (06-03-2010
20090088723APPARATUS AND METHODS FOR TREATING PSEUDOANEURYSMS - Apparatus and methods are provided for treating pseudoaneurysms using freeze-dried hydrogel particles that expand and/or absorb fluid within a pseudoaneurysm. An apparatus includes an elongate tubular member including a proximal end, a distal end sized for introduction through tissue into a pseudoaneurysm or other body cavity, and a lumen communicating with an outlet on the distal end. The particles are provided within the lumen and dischargeable through the outlet, e.g., using a plunger or other actuator. The apparatus may include one or more of a bled-back channel, flow sensor, pressure sensor, and markers for monitoring the distal end during introduction into the pseudoaneurysm.04-02-2009
20090024106Method and apparatus for maintaining access - An apparatus and a method for sealing a puncture in a tubular tissue structure or the wall of a body cavity are provided.01-22-2009
20110230858METHODS AND DEVICES FOR PROVIDING OXYGENATED BLOOD DISTAL TO AN OBSTRUCTION - The catheter is positioned within an obstruction so that the distal end is positioned distal to the obstruction and proximal openings are positioned proximal to the obstruction. Blood enters the proximal openings and passes through the lumen to the distal end to perfuse blood distal to the obstruction.09-22-2011
20080269720Cardiac repair, resizing and reshaping using the venous system of the heart - Structurally supportive material is implanted or injected into cardiac veins as discrete masses at various sites in the cardiac venous system to reinforce the myocardium for the purpose of preventing, moderating, stopping or reversing negative cardiac remodeling due to various adverse cardiac conditions, both acute and chronic, or for the purpose of treating localize anomalies of the heart, or for both purposes. The sites may be arranged in a pattern about one or more chambers of the heart such that the masses cooperatively reduce stress in the chamber wall and reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Patterns of distribution of discrete masses in the heart for global resizing and reshaping may also be used as is or augmented by supplemental patterns to treat localized conditions such as myocardial infarctions and overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.10-30-2008
20090247986Flapper Valve with Membrane Bypass for Power PICC - A bypass for power injection includes (a) a housing defining a lumen extending from a proximal end to a distal end coupled to a catheter; (b) a membrane valve mounted within the lumen, the membrane valve having an opening extending therethrough sized to tightly receive therethrough and seal around a power injection device; and (c) a flapper valve extending across the lumen distally of the membrane valve. The flapper valve includes a flap biased toward a closed position in which the lumen is sealed. The flap is rotatable away from the closed position when contacted by a power injection device to permit the device to extend therethrough.10-01-2009
20090254062Infusion catheters with slit valves and of simplified construction - The present invention relates to catheters to deliver a fluid to a patient. A catheter of the invention comprises a plurality of slits through which the fluid is delivered to the patent. A catheter of the invention is designed in a simple manner to lower costs and provide a reliable means to deliver fluids to a patient. The invention further comprises methods for making a catheter of the invention and methods of delivering a fluid to a patient with a catheter of the invention.10-08-2009
20100160898METHOD AND APPARATUS FOR STORAGE AND/OR INTRODUCTION OF IMPLANT FOR HOLLOW ANATOMICAL STRUCTURE - Apparatus for advancing a vascular implant into a blood vessel. The apparatus comprises a first elongate member, the first elongate member having sufficient column strength to function as a pusher member; and a second elongate member, the second elongate member being thinner than the first elongate member and extending to a distal end located at a first point which is at or near a distal end of the first elongate member. The elongate members form an implant retaining portion while the distal end of the second elongate member is located at the first point. The implant retaining portion is located proximal of the first point. The implant retaining portion comprises a space located between the elongate members and configured for receiving an implant portion, with the first elongate member on one side of the space and the second elongate member on another side. The implant retaining portion further comprises a proximal side and a distal side which further circumscribe the space. The proximal and distal sides are effective to prevent an implant received in the retaining portion from moving out of engagement with the retaining portion as the first elongate member is moved distally and proximally. The implant retaining portion is removable by withdrawing the second elongate member in a proximal direction with respect to the first elongate member, thereby moving the distal end of the elongate member proximally beyond the former location of the implant retaining portion. Associated methods, and other apparatus and methods, are also disclosed.06-24-2010
20100160897Apparatus and Methods for Containing and Delivering Therapeutic Agents - The present embodiments provide apparatus and methods suitable for containing and delivering a therapeutic agent to a target site. The apparatus generally comprises at least one container for holding a therapeutic agent, and a pressure source for facilitating delivery of the therapeutic agent. In one embodiment, the pressure source may be placed in selective fluid communication with a proximal region of the container and fluid from the pressure source may flow through at least a portion of the container to urge the therapeutic agent through the container towards the target site. In an alternative embodiment, the pressure source may be selectively in fluid communication with either a first hollow tube and the container so that therapeutic agent is urged into a catheter, or with a second hollow tube and a catheter so that a fluid from the pressure source bypasses the container and enters the catheter.06-24-2010
20100191219Bacteriostatic Catheter Lock Containing Glycerol - A catheter lock composition for preventing bacterial infection having an effective amount of glycerol and sodium chloride solution. The effective amount of glycerol is between about 35-60% and sodium chloride is in a concentration range between 0.5-0.9%. The composition further includes an anticoagulant and/or an antimicrobial agent.07-29-2010
20120035587METHODS AND SYSTEMS FOR PROVIDING THERAPIES INTO THE PERICARDIAL SPACE - Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver a pharmacologic agent, particularly a NO-donor drug, to the heart are disclosed. A proximal connector of an infusion catheter is coupled to an infusion pump, and a distal catheter segment having a distal infusion catheter lumen end opening is disposed in the pericardial space. The implantable infusion pump is operable in conjunction with an implantable ischemia monitor to monitor the ischemic state and trigger delivery or regulate the periodic delivery of the pharmacologic agent to optimally treat ischemia. The patient may operate a patient activator that the patient when feeling ischemia symptoms to transmit a signal that is received by the implantable infusion pump and triggers delivery of a bolus and/or continuous infusion.02-09-2012
20100137834SYRINGE ASSEMBLY - A syringe assembly comprises a syringe barrel having an elongated body defining a chamber for retaining fluid, an open proximal end, a distal end and a frusto-conically shaped tip extending from the distal end and having a passageway therethrough in fluid communication with the chamber. The chamber has an inside diameter of at least 13.5 mm. A stopper is in fluid-tight engagement inside the barrel. An elongated plunger rod extends proximally from the stopper through the open proximal end of the barrel. A flange is positioned at the proximal end of the plunger rod. The flange is shaped and positioned to limit the distal motion of the plunger rod in the barrel by contacting the proximal end of the barrel. A tip cap is releasably connected to the tip for sealing the passageway and the chamber contains injectable liquid.06-03-2010
20130131636METHODS OF TREATING MEDICAL CONDITIONS BY TRANSVASCULAR NEUROMODULATION OF THE AUTONOMIC NERVOUS SYSTEM - The present invention is directed to a method of treating a respiratory or pulmonary condition by transvascular neuromodulation of a target site adjacent to an adrenal gland. A method for treating a respiratory or pulmonary condition via transvascular neuromodulation incorporating a closed-loop feedback system is also provided.05-23-2013
20100318061Catheter - The invention relates to rigid surgical devices formed from rigid ceramics such as zirconium dioxide. In particular, the invention relates to a neurosurgical catheter formed from extruded zirconium dioxide. The invention also relates to an advancement means for advancing or retracting such a device along an axis of insertion into a patient.12-16-2010
20130138080MEDICAL ARTICLE WITH ROTATABLE WINGS - A medical article is configured to provide access to a patient's vasculature. The medical article includes an elongated body and a pair of stabilizing wings that extend from the elongated body and are configured to stabilize the medical article on a patient. The stabilizing wings are configured to rotate together or independently about the longitudinal axis of the elongated body between at least a first configuration and a second configuration. The elongated body can include a one-way valve disposed therein. The medical article can also one or more adhesive layers configured to releasably attach at least a portion of the wings to a patient.05-30-2013
20110130744DEVICES, SYSTEMS, AND METHODS FOR ACCESSING THE EPICARDIAL SURFACE OF THE HEART - Devices, systems, and methods for accessing the internal and external tissues of the heart are disclosed. At least some of the embodiments disclosed herein provide access to the external surface of the heart through the pericardial space for localized delivery of leads to the heart tissue. In addition, various disclosed embodiments provide devices, systems, and methods for closing a hole in cardiac tissue.06-02-2011
20100217232BYPASS VALVE - An intravenous fluid administration apparatus may include a proximal conduit having a spiked first end for attaching to a reservoir of fluid and a second end, a distal conduit, an intermediate conduit network providing fluid communication from the proximal conduit's second end to the distal conduit and including first and second constituent conduits that provide parallel paths from the proximal conduit to the distal conduit, a flow regulator so engaged with the first constituent conduit as to enable control of fluid flow therethrough, and a pressure-responsive valve so interposed in the second constituent conduit as to permit flow from the proximal conduit to the distal conduit through the second constituent conduit when a fluid pressure difference across the valve exceeds a threshold and to prevent such flow when the difference does not exceed the threshold.08-26-2010
20090048576Managing Cross-contamination in Blood Samples Withdrawn from a Multilumen Catheter - The present invention comprises methods and apparatuses that can provide accurate measurement of glucose or other analytes from a multilumen catheter in the presence of infusion of substances, including glucose. Examples of “multilumen catheters” include central venous catheters having multiple lumens, midline catheters having multiple lumens, multiple catheters configured or emplaced such that their lumens are in proximity to each other, and, in the case of indwelling analyte sensors, a catheter with a lumen for infusion and an indwelling sensor spaced apart from the infusion lumen. For blood withdrawal, anti-cross contamination controls can prevent the entrainment of blood which might be contaminated with feeding fluids or medications that are administered through other lumens within the catheter and in proximity of the blood sampling port. Cross contamination can occur under various situations, and is known to occur when the patient is connected to a ventilator. The ventilator cyclically raises the intra-thoracic pressure and diminishes blood flow rate in the central veins returning to the heart. The diminished flow can increase the chances for cross-contamination when additional lumens are introducing fluids during a draw sample.02-19-2009
20110251589Catheter With Distensible and Frangible Cap - A catheter for delivering a medical implant in a patient's vasculature includes an elongate catheter having a distensible and frangible cap mounted across the open distal end thereof. The cap is distendable by pressure within the catheter to provide a bumper tip for guiding the catheter through a patient's vasculature. At the desired site for deploying the medical implant, the cap is ruptured to permit the implant to be advanced through the distal opening. Methods of using the catheter are also disclosed.10-13-2011
20110071496BIOLOGICS INFUSION SYSTEM - A system for moving particles suspended in a first fluid, and for infusing them into the stream of a second fluid, includes a catheter with a multi-lumen distal tip. The tip is formed with a plurality of parallel lumens, wherein each lumen has a predetermined diameter. Importantly, the diameter of each lumen is dimensioned to sequentially receive particles therethrough, to prevent the particles from flocculating before they enter the stream of the second fluid. A valve, affixed to the outside of the catheter, can be provided to regulate flow of the second fluid and thereby facilitate entry of the particles into the stream of the second fluid.03-24-2011
20110071495SHAPE MEMORY EMBOLIC PARTICLES HAVING A HIGH PACKING FRACTION - An embolization system having a high packing fraction of embolic particles for use in occluding the flow of body fluid through a body vessel and a method for using such an embolization system are described. The embolic particles, which are made from a shape memory material, exhibit both a collapsed state and an expanded state. The embolic particles exhibit at least a bimodal particle diameter distribution in the collapsed state and expanded state with a particle packing fraction of at least about 0.85. The mixture of embolic particles is delivered into the body vessel in the collapsed state. The particle packing fraction of the mixture in its expanded state causes the occlusion of the flow of body fluid through the body vessel.03-24-2011
20120302995Localized Therapy Delivery and Local Organ Protection - A system for perfusing a localized site within a body includes a catheter assembly having a venous access line that is adapted to deliver perfusate to the localized site, a venous or arterial drainage line adapted to drain perfusate from the localized site, and an occlusion device adapted to prevent some or substantially all physiological blood flow between the localized site and the systemic circulation of the body during and in the course of perfusing and draining perfusate to and from the localized site. The system may include a blood circuit associated with the catheter assembly to facilitate blood conditioning for use as the perfusate, in the course of a controlled perfusion and/or drainage of untreated, treated, or inactivated treated blood to and from the localized site. A delivery machine may control the blood circuit and catheter assembly in order to both deliver perfusate to, and drain some or all perfusate from, the localized site in a manner that provides perfusate to substantially only the localized site.11-29-2012
20100114062Methods and devices for providing oxygenated blood distal to an obstruction - The catheter is positioned within an obstruction so that the distal end is positioned distal to the obstruction and proximal openings are positioned proximal to the obstruction. Blood enters the proximal openings and passes through the lumen to the distal end to perfuse blood distal to the obstruction.05-06-2010
20100004627NEEDLE CATHETER WITH AN ANGLED DISTAL TIP LUMEN - A needle catheter configured for injecting an agent into a wall of a patient's body cavity, which directs a needle from the distal tip of the catheter into the wall of the body cavity at an angle relative to the axis of the shaft. The resulting angled injection pathway improves the retention of the agent in the body cavity wall, while keeping a distal section of the catheter substantially perpendicular to the body cavity wall for optimal push against the tissue at the injection site.01-07-2010
20120203202METHOD AND APPARATUS FOR DELIVERING AN AGENT TO A KIDNEY - A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.08-09-2012
20120203201Methods for Preparing a Heat Exchange Catheter System and for Heating and/or Cooling a Subject's Body - Closed loop heat exchange catheter systems and methods for preparing and using such systems wherein a reservoir or fluid bag is connected to the catheter system and used for at least priming of the system with a heat exchange fluid.08-09-2012
20080269719IMPLANTABLE MEDICAL DEVICE DELIVERY SYSTEM WITH A FRANGIBLE PORTION AND METHODS OF MAKING AND USING THE SAME - An implantable medical device delivery system is provided with a carrier member having a proximal portion, a distal portion, and a frangible portion intermediate the proximal and distal portions. The frangible portion includes at least one notch providing a break hinge. A locking member is fixedly secured to the proximal portion of the carrier member and is releasably connected to an implantable medical device at or adjacent to the distal portion of the carrier member. In use, the implantable medical device is positioned generally adjacent to a target location of a body vessel and the frangible portion is broken about the break hinge. The proximal portion of the carrier member is then moved away from the distal portion to retract the locking member, thereby deploying the implantable medical device.10-30-2008
20100324533CATHETER SYSTEM AND METHOD FOR DELIVERY OF THERAPEUTIC COMPOUNDS TO CARDIAC TISSUE - This is a method and an apparatus for the treatment or introduction of contrast fluids into tissue, particularly cardiac tissue. The apparatus includes a catheter having an elongated flexible body and a tissue infusion apparatus including a hollow infusion needle configured to secure the needle into the tissue when the needle is at least partially inserted into the tissue to help prevent inadvertent removal of the needle from the tissue. This permits the selected treatment or contrast fluid to be confined to a specific site. The catheter may also include a visualization assembly including a transducer at the distal end of the body.12-23-2010
20110218517IN VIVO CHEMICAL STABILIZATION OF VULNERABLE PLAQUE - Procedures for the stabilization of vulnerable plaque can comprise identification of the vulnerable plaque and the delivery of a stabilization composition to the location of the vulnerable plaque. For example, the stabilization composition can be delivered to an isolated portion of the vessel with the vulnerable plaque and/or alternatively or additionally using a profusion balloon that delivers the stabilization composition at the vessel wall near the vulnerable plaque. Suitable stabilization compositions can comprise a collagen crosslinking agent, an elastin stabilization agent, VEGF or a combination thereof. Vascular endothelial growth factor (VEGF) can be used to encourage endothelialization of the vessel wall near the vulnerable plaque.09-08-2011
20100016831Catheter Having an Oblong Slit - A catheter (01-21-2010
20100016832SPIRALLY CONFORMABLE INFUSION CATHETER - An infusion catheter includes a catheter body having a proximal end, a distal end, and two or more lumens extending therethrough. The infusion catheter also includes an infusion tube having a proximal end, a distal end, and one or more ports disposed therethrough. The first lumen of the catheter body is in fluid communication with the lumen of the infusion tube. A central member has a distal end connected to the distal end of the infusion tube, a proximal end, and a proximal portion slidably received in the second lumen of the catheter body. The infusion tube is disposed relative to the central member such that axial advancement of the central member relative to the catheter body radially collapses the infusion tube over the central member and axial retraction of the central member relative to the catheter body radially expands the infusion tube about the central member.01-21-2010
20110152835METHODS AND COMPOSITIONS FOR THE REPAIR AND/OR REGENERATION OF DAMAGED MYOCARDIUM - Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration cytokines are disclosed and claimed. Methods and compositions for the development of large arteries and vessels are also disclosed and claimed. The present application also discloses and claims methods and media for the growth, expansion, and activation of human cardiac stem cells.06-23-2011
20110144620INTRAVASCULAR CATHETER WITH POSITIONING MARKERS AND METHOD OF PLACEMENT - An intravascular catheter may include a distal end for insertion and a proximal end. The distal end for insertion may terminate with a tip. It may define at least two openings, of which one is proximal-most in the distal end. The distal tip may include a first radiopaque marker that is discretely positioned at the proximal-most opening and radiographically distinguishes the proximal-most opening from the rest of the distal end. The distal tip may also include a second radiopaque marker that marks the tip.06-16-2011
20090118700METHOD FOR TREATING CORONARY VESSELS - A method is provided including introducing a delivery device through a vessel wall to a treatment site within one of a peri-adventitial space or a pericardium adjacent a coronary blood vessel and delivering a treatment agent through the delivery device. The treatment agent is delivered through the delivery device according to conditions that hydraulically dissect tissue planes within the peri-adventitial space. A kit is provided including a delivery device having a needle to be advanced through one of an epicardium of a heart and a wall of a coronary blood vessel into a peri-adventitial space and a treatment agent comprising particles having an average diameter on the order of 15 microns or more to be delivered through the delivery device into the peri-adventitial space.05-07-2009
20120310209Catheter And Treatment Methods For Lower Leg Ischemia - A method of treating lower leg ischemia includes advancing a wire guide upstream through a vascular access sheath extending into an artery, and increasing a downstream flow of blood at least in part by dilating a constriction in the artery with a treatment mechanism guided into the constriction via the wire guide. The method further includes withdrawing a catheter which is coupled with the treatment mechanism from the patient at the percutaneous entry point via sliding the catheter downstream through the vascular access sheath. A low profile balloon may be used as the treatment mechanism, and is advanced through the artery while the vascular access sheath protects the artery from irritation such that spasm of the artery is less likely to occur. Reduced risk of spasm advantageously enables retrograde access to chronic total occlusions such that multiple entry points into a patient's body are not necessary.12-06-2012
20120059355METHODS OF MODIFYING MYOCARDIAL INFARCTION EXPANSION - A reinforcement region is formed within the myocardium by introducing a delivery device through a vessel wall to a treatment site within a myocardium. A biomaterial is then delivered to the treatment site as the delivery device is withdrawn from the treatment site to form the reinforcement regions. Formation of the reinforcement region may further include introducing a delivery device through a vessel wall to a region within a myocardium such that the delivery device is positioned within the myocardium substantially parallel to a wall of the myocardium. A biomaterial may be delivered into a space formed within the region by the delivery device. The reinforcement region may be formed around an infarct tissue region of a myocardium to reinforce the damaged tissue.03-08-2012
20120116351Method of Operating a Microvalve Protection Device - An endovascular valve device for use in a vessel during a therapy procedure includes a catheter having at its distal end a valve. The valve is constructed of a braid of elongate first filaments coupled together at their proximal ends in a manner that the first filaments are movable relative to each other along their lengths. The first filaments have a spring bias that radially expands the valve. A filter is provided to the braid formed by electrostatically depositing or spinning polymeric second filaments onto the braided first filaments. The lumen of the catheter is in communication with the center of the valve. The device is used to provide a therapy in which a therapeutic agent is infused into an organ.05-10-2012
20120116350TRANSLATION DILATOR AND STAND ALONE VASCULAR GUIDE CATHETER - Systems and methods for delivering implantable devices, catheters, or substances in or near and/or restoring flow through body lumens, such as blood vessel lumens are described. A catheter having a proximal portion of a first diameter and a distal portion of a second diameter (smaller than the first diameter) is advanced into a body lumen. The distal portion of the catheter is caused to expand to a diameter that is larger than the second diameter but no larger than the first diameter. A working device is then advanced out of the distal end of the catheter and used to remove obstructive matter, deliver an implantable device or substance and/or restore flow. The distal portion can be reduced in diameter prior to removal from the body. A stand alone, guide catheter is also disclosed possessing high resistance to kinking even with a very thin wall.05-10-2012
20120172837METHODS FOR INHIBITING RENAL NERVE ACTIVITY VIA AN INTRA-TO-EXTRAVASCULAR APPROACH - Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.07-05-2012
20100049165DETACHABLE TIP MICROCATHETER - A microcatheter for delivering embolic agent to a vascular site is provided. The microcatheter has a biocompatible or biocompatible and biodegradable tip which can be detachably engaged to the microcatheter body by a thermoplastic sleeve. Once the embolic agent is delivered to the desired vascular site, the tip of the microcatheter is often entrapped within the mass of the liquid embolic fluid. Using the microcatheter, the clinician can retract the microcatheter at a predetermined retraction force thereby disengaging the tip from the microcatheter body allowing for easier removal of the microcatheter.02-25-2010
20090318890Portable Medical Foam Apparatus - An apparatus for producing medical foam having a foam generation unit including a fluid reservoir, a fluid delivery line and a foam generation tip; and a compressed gas unit including at least one container of compressed gas, a source of electric power, and a gas regulator valve.12-24-2009
20100305547Method of use of fibroblast growth factor, vascular endothelial growth factor and related proteins in the treatment of acute and chronic heart disease - Disclosed herein is a rational, multi-tier approach to the administration of growth factor proteins in the treatment of heart disease. Also disclosed is a method to evaluate the effectiveness of the administration of growth factor proteins comprising the clinical assay of CPK-MB levels in a patient undergoing treatment with growth factor proteins. In addition, there is disclosed a method for treatment of heart disease comprising administration of a therapeutically effective amount of a growth factor protein by oral inhalation therapy.12-02-2010
20100010469PRE-FORMED DELIVERY CATHETERS - A delivery catheter includes a pre-formed and resilient heart-wrapping segment. The segment may have a relaxed span that allows the segment to wrap around a left side of a heart from an anterior epicardial surface to a posterior epicardial surface, when the catheter is advanced along the epicardial surface, having been inserted from a sub-xiphoid access site.01-14-2010
20130172851DISTAL ACCESS ASPIRATION GUIDE CATHETER - Distal access aspiration guide catheter system and methods for delivering implantable devices, catheters, or substances in or near and/or restoring flow through body lumens, such as blood vessel lumens are described. A distal access aspiration guide catheter having a proximal, medial, and distal possessing high flexibility, high resistance to kinking and a large lumen to wall thickness ratio.07-04-2013
20090018526Devices and Methods for Perfusing an Organ - The present invention provides devices and methods for use in the perfusion of organs and anatomical regions. In one aspect the present method provides a percutaneously deliverable device for supporting a vessel in a human or animal subject including means for supporting the vessel during delivery of a fluid thereto or collection of a fluid therefrom. In another aspect the invention provides a method for delivery or collection of a fluid to or from an organ or anatomical region in a human or animal subject, the method including the step of supporting a vessel associated with the organ or anatomical region. The devices and methods may be used to deliver, remove or recirculate a therapeutic agent to an organ or anatomical region.01-15-2009
20110238039Method and Apparatus for Improving Delivery of an Agent to a Kidney - Methods for more uniformly delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These methods use one or more strategies to facilitate rapid mixing with the blood flowing past a device or otherwise improve the uniformity of drug delivery. Some of these strategies employ medical devices with diffusion members.09-29-2011
20120277725SYSTEMS AND METHODS FOR ENGAGING HEART TISSUE - A system for engaging heart tissue includes an engagement catheter defining a first lumen therethrough and having a suction port at or near a distal end and a vacuum port at or near a proximal end, a delivery catheter defining a delivery catheter lumen therethrough and configured for slidable insertion into the first lumen of the engagement catheter, and an implantable device capable of insertion into the delivery catheter lumen such that at least part of the implantable device extends from a delivery catheter distal end upon implantation into a patient, where the suction port is operable to removably attach to a targeted tissue on an interior wall of a heart of the patient after the engagement catheter has been advanced through a blood vessel and into the heart, thereby forming a reversible seal with the targeted tissue when a vacuum source is operatively coupled to the vacuum port.11-01-2012
20100185179NEEDLED CANNULA WITH FILTER DEVICE - An apparatus may include a cannula. The cannula may be operable to be percutaneously advanced through a blood vessel. The cannula may have a proximal end and a distal end. At least one needle may be coupled to the distal end of the cannula. A filter device may be coupled at a position proximal to the at least one needle. The filter device may have a distal portion that is operable to have a first diameter under a first condition and a second, different diameter under a second condition. Methods of using such an apparatus are also disclosed.07-22-2010
20100168713CATHETER FOR INTRODUCTION OF MEDICATIONS TO THE TISSUES OF A HEART OR OTHER ORGAN - A positionable, direct-injection catheter that can access a specific region of the heart or other organ. The catheter is provided with one or two needle shafts, which may be located within respective sheaths that extend axially along the interior of the lumen of a main catheter shaft. Each needle shaft carries, at a distal end thereof a penetrable element or “needle” that is normally retracted within the distal tip of the main shaft during travel to the target organ, but is subsequently deployed by action of a handle-mounted trigger mechanism to extend the needles into the organ's wall. Each extended needle is curved to relative to the shaft's axis to enter the organ wall in a flattened trajectory that both reduces the chance of puncture through the wall and anchors the needles into the wall during injection (for reduced chance of pullout under pressure). A plurality of apertures which provide for more complete agent delivery rapidly, while maintaining a low delivery velocity to effect treatment delivery in as short a period of time as possible without the problems caused by high velocity delivery. The needles are typically arranged to exit the tip at contralateral orientations relative to each other.07-01-2010
20130023852Flow Protection Device - A catheter for provides protection to the brachiocephalic and left common carotid arteries against embolic delivery associated with transcatheter aortic valve implantation (TAVI). A catheter having two lumens is introduced into the radial artery and the distal end is delivered to the aorta and an intermediate end is delivered to the brachiocephalic artery. Blood is taken from the aorta and is delivered to the intermediate end via a pump. Fluid flow out of the brachiocephalic artery prevents embolic debris from entering the brachiocephalic artery; streamlines of blood flow into the aorta prevent embolic debris from entering the neighboring left common carotid artery.01-24-2013
20130172852ENDOLUMINAL DELIVERY OF ANESTHESIA - Described herein are methods and devices for selectively applying fluids (particularly anesthetics) to a target tissue from within a blood vessel while minimizing the amount of fluid applied to non-target tissue. The injection catheters described herein may include an elongate body, a directional injector, and one or more holdfasts for securing the catheter before extending the injector. The methods of selectively applying anesthetic to a target structure generally include the steps of inserting an injection catheter into a body vessel, positioning the injection catheter within the body vessel near the target structure, anchoring the injection catheter before extending a directional injector from the injection catheter, and applying anesthetic from the injection catheter to the target structure.07-04-2013
20080234658Device and Methods for Controlling Blood Perfusion Pressure Using a Retrograde Cannula - Devices and methods are disclosed for the control of blood perfusion pressure within a blood vessel that undergoes arterialization. A cannula is introduced that contains a stenosis that either resorbs or is removed in time, allowing a gradual increase in blood pressure between two blood passages connected at either ends of the cannula. Particular emphasis has been made with the use of the cannula for the vessels in the heart.09-25-2008
20080234657METHODS FOR CONTRIBUTING TO CARDIOVASCULAR TREATMENTS - Disclosed herein are methods that can contribute to cardiovascular treatments. The methods are designed to provide bioactive materials to the first proximal third of coronary arteries, the portion of these arteries most likely requiring treatment.09-25-2008
20110264073DEVICE AND METHOD FOR CONTROLLING INJECTION OF LIQUID EMBOLIC COMPOSITION - A liquid embolic delivery system is provided for trapping an injected liquid embolic composition to prevent the liquid embolic from solidifying or otherwise passing outside of an embolization area. The delivery system includes a catheter for delivery of a liquid embolic composition and a containment member positioned at a distal end of the catheter which is shaped to trap the liquid embolic composition delivered through the lumen of the catheter. The containment member is formed as a brush, nest, sponge, swab, flexible sack, or other shape into and around which the liquid embolic composition is injected. The liquid embolic composition is trapped or meshes with the containment member during solidification containing the liquid embolic and preventing the embolic composition from passing into the blood stream.10-27-2011
20080221551ACUTE KIDNEY INJURY TREATMENT SYSTEMS AND METHODS - Systems and methods for the clinical treatment of individuals susceptible to or suffering from acute kidney injury are provided. Drugs, biologics, or other therapies or treatments are administered by fluid agent delivery directly to the kidneys via their arterial blood supply. Bifurcated renal artery infusion catheter devices and methods can treat kidney injury in patients with locally-delivered drugs, biologics, and other agents, so as to increase the ability of the kidneys to excrete nitrogenous waste products from the blood, and prevent or ameliorate azotemia.09-11-2008
20080221550RAPID EXCHANGE INFUSION CATHETER - An infusion catheter and method, with an elongated shaft having a guidewire lumen which has a proximal section and a common distal section extending to a distal port at a distal end of the shaft, and an infusion lumen which is in fluid communication with the distal port of the guidewire lumen and which joins the common distal section of the guidewire lumen at a location distal to the guidewire proximal port. A restricted passage from the infusion lumen to the common distal section of the guidewire lumen has a smaller transverse dimension than the guidewire lumen and a guidewire slidably disposed in the guidewire lumen.09-11-2008
20130204231METHOD FOR APPLYING ANTIMICROBIAL TO PROXIMAL END OF CATHETER - Systems, methods, and articles for delivering an antimicrobial composition to the proximal elements of a trans-dermal catheter and into the lumen of the transdermal catheter are disclosed. In an embodiment, an antimicrobial composition placed on an interior surface a cap element, and transfers antimicrobial to the exterior of the proximal end of the transdermal catheter. The system comprises an elongate member configured for insertion into a lumen of a catheter, the elongate member containing an antimicrobial.08-08-2013
20100286657HIGH-FLOW TAPERED PERIPHERAL IV CATHETER WITH SIDE OUTLETS - A high-volume peripheral intravenous (IV) catheter and method includes an elongate stylet removably disposed in the lumen of an elongate catheter with the stylet having a beveled distal end forming a piercing tip that protrudes from the outlet port of the catheter. The catheter has a proximal cylindrical shape from the inlet port transitioning at a transition to an inner lumen conical taper terminating at the outlet port, and having a larger internal diameter at the inlet port and a tapering smaller internal diameter between the transition and the outlet port. A plurality of side outlet ports is formed laterally through the catheter in the inner lumen conical taper. A cross-sectional area of the outlet port and the side outlet ports together is equal or greater than a cross-sectional area of the inlet port.11-11-2010
20110251588Infusion Mechanism And Method - An infusion mechanism for treating an intraluminal site in a patient includes an infusion catheter having an elongate body with a proximal body end defining at least one fluid supply orifice, and a distal body end. The elongate body defines a high head loss lumen in fluid communication with a first set of side ports defining a proximal infusion zone. The elongate body further defines a low head loss lumen in fluid communication with a second set of side ports defining a distal infusion zone.10-13-2011
20130158509SYSTEM, APPARATUS, AND METHOD FOR DENERVATING AN ARTERY - The present disclosed subject matter is directed to a less invasive surgical system, apparatus and method including a guidable catheter for providing electroporation therapy to a subject suffering from heart or kidney disease. The system includes an electrical generator and an apparatus for denervating an artery. The apparatus includes a catheter having a proximal end, a distal end, a first lumen with a first exit port, a second lumen having a second exit port. The apparatus also includes a first needle including a first electrode. The apparatus also includes a displacement mechanism engaged to the catheter near the proximal end such that the displacement mechanism controls the linear position and angular position of the catheter.06-20-2013
20130184679DEVICE FOR DELIVERY OF ANTIMICROBIAL AGENT INTO TRANS-DERMAL CATHETER - A system, method, and article for delivering an antimicrobial agent into the lumen of a trans-dermal catheter are disclosed. In an embodiment, the system comprises an elongate member configured for insertion into a lumen of a catheter, and the elongate member containing an antimicrobial. In the alternative an antimicrobial agent can be placed on an interior surface of a retaining ring.07-18-2013
20130190724PREVENTION OF INDWELLING DEVICE RELATED INFECTION: COMPOSITION AND METHODS - Catheters used for medical treatment, e.g., hemodialysis are filled with a locking solution, usually heparin between treatments. To prevent infections, antimicrobial or antibiotic substances have been used as locking solution alone or in combination with antithrombotic substances. It has been found that these locking solutions are rapidly washed out from the catheter tip. The invention describes a thixotropic gel that can be used as locking solution. Beneficial substances, e.g., antimicrobial or antibiotic substances can be added to the gel. A preferred antimicrobial substance is taurolidin alone or in combination with salicylic acid or one of its salts.07-25-2013
20130204230Expandable Catheter - A fluid delivery mechanism that has a substantially cylindrical sleeve and an actuator coupled to the sleeve for controlling a circumference of the sleeve.08-08-2013
20130211378PUMP AND MONITOR FOR IV PRESSURE INFUSERS - A pumping device that can be used with currently-available pressure bag infusers is disclosed. The pumping device is hand-held and lightweight. The device is controlled by a microprocessor. Thus constant pressure to the bag is maintained through automatic adjustment of pumping and venting functions. In addition, a novel, new pressure bag infuser and a modified Luer Lock fitting for use with the pumping device are described.08-15-2013
20130211379CATHETER ASSEMBLY AND METHOD OF TREATING A VASCULAR DISEASE - A catheter assembly comprises a catheter including a catheter wall and a lumen extending lengthwise of the wall. The wall has inner and outer surfaces. The wall includes plural openings that extend through the wall and communicate with the lumen. An elongated hollow needle includes a proximal end portion and a distal end portion. The needle is movable in the lumen to move the distal end portion between the openings. The distal end portion is directed radially outward so as to extend into an adjacent opening. The distal end portion has a configuration that stores potential energy when in the lumen. The potential energy is converted to kinetic energy to produce movement of the proximal end portion as the distal end portion moves from the inner surface of the catheter wall across an edge of an opening. The movement of the proximal end portion is haptically perceptible.08-15-2013
20130211380Compartmentalized method of nucleic acid delivery and compositions and uses thereof - Provided herein is a method of delivering nucleic acid molecules to a compartmentalized tissue or organ of a subject. Also provided herein are uses and processes for delivering a nucleic acid molecule to the parenchyma of a compartmentalized tissue or organ. The methods and uses can be used in the treatment of diseases and conditions and in industrial, agricultural and veterinary applications. Also provided herein are compositions containing an adenovirus or adeno-associated virus or other recombinant virus formulated for administration to the parenchyma of a tissue or organ.08-15-2013

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