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Therapeutic material introduced or removed through a piercing conduit (e.g., trocar) inserted into body

Subclass of:

604 - Surgery

604019000 - MEANS FOR INTRODUCING OR REMOVING MATERIAL FROM BODY FOR THERAPEUTIC PURPOSES (E.G., MEDICATING, IRRIGATING, ASPIRATING, ETC.)

604048000 - Treating material introduced into or removed from body orifice, or inserted or removed subcutaneously other than by diffusing through skin

604500000 - Method

Patent class list (only not empty are listed)

Deeper subclasses:

Class / Patent application numberDescriptionNumber of patent applications / Date published
604507000 Therapeutic material introduced into or removed from vasculature 274
604513000 Including docking element, port or sealing means 25
604512000 For anesthetizing patient 18
604511000 Therapeutic material introduced into or removed from musculature 16
Entries
DocumentTitleDate
20130072900APPARATUS AND METHOD FOR SAFELY INSERTING AN INTRODUCER NEEDLE INTO EPIDURAL SPACE - An epidural needle assembly is provided, permitting the accurate introduction of a large bore introducer sleeve needle into the epidural space in the spinal column of a patient using the loss of resistance technique. The large bore introducer needle has a beveled side opening at its tip and with a tissue piercing point at the distal extension of the needle. A syringe needle is received within the introducer needle with a distal head of the syringe needle filling the beveled side opening at the distal end of the introducer needle when the syringe hub is fully seated. The lumen of the syringe needle exits the syringe needle head at the side opening of the introducer needle immediately adjacent the tissue piercing point of the introducing needle. The needle assembly may be inserted and advanced, with precise tactile feedback, into a patient, thus accurately detecting the introduction of the introducer needle into epidural space.03-21-2013
20110178500FIRING BUTTON FOR AUTOMATIC INJECTION DEVICE - Exemplary embodiments provide firing mechanism assemblies that minimize or eliminate a misfire of an automatic injection device that causes a delay in the delivery of an injection. Exemplary embodiments provide automatic injection devices including firing mechanism assemblies that minimize or eliminate a misfire that causes a delay in the delivery of an injection. Exemplary embodiments provide methods for minimizing or eliminating misfire that causes a delay in delivery of an injection in automatic injection devices. Exemplary embodiments provide methods for using automatic injection devices that are free of a misfire that causes delay in delivery of a therapeutic substance into a patient's body.07-21-2011
20120203199Method and apparatus for providing access to an internal body organ - Catheter systems and methods for facilitating the delivery of a therapeutic agent directly to the interior of a body organ, and/or the extraction of material from said organ. The catheter distal end is placed within the body organ to be treated. The catheter may carry a fixation device near the catheter distal end. When implanted, the fixation device retains the catheter distal end in the organ despite normal patient activity. The fixation device may include porous material to promote soft tissue ingrowth for anchoring the catheter distal end within the organ.08-09-2012
20130030409DRUG DELIVERY DEVICE, ASSEMBLY FOR A DRUG DELIVERY DEVICE AND METHOD FOR SETTING UP A DRUG DELIVERY DEVICE - The instant application is directed to an assembly for a drug delivery device which is arranged to operate in two distinct modes, a priming mode starting from a pre-priming state and a dispense mode operating in a post-priming state, and a drug delivery device comprising this assembly. The assembly comprises a dose member, an actuating member and a piston rod which is configured to act on a bung of an assembled cartridge containing the drug. In the pre-priming state the actuating member is configured to be moved by a user such that the movement of the actuating member causes a movement of the dose member and such that the movement of the dose member causes a movement of the piston rod. In the post-priming state the dose member is configured to be moved by a user without causing a movement of the actuating member in order to perform a set and dispense action of the drug delivery device.01-31-2013
20100160895Apparatus and Method for Transdermal Delivery of Parathyroid Hormone Agents - An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.06-24-2010
20120172834TISSUE SAMPLING, PROCESSING AND COLLECTION DEVICE AND METHOD OF USING SAME - Methods of collecting fat tissue samples in tissue collection syringes mounted in an in-line fat sampling device connected to a hand-held power-assisted tissue aspiration instrument.07-05-2012
20100087796Method For Controlling A Pump Drive - A syringe pump and associated computer are provided to achieve an ultra-low flow rate. The computer may generate syntax commands to a motion controller of the syringe pump to displace a plunger by a selected number of steps or increments and pause a period of time before repeating the displace and pause steps. The cycle may be repeated until a desired end condition has been reached. The syringe pump and computer may be embodied as separate linked units or as a standalone unit wherein the computer is an embedded controller located within the syringe pump housing. The invention may also be embodied as a method for achieving ultra-low flow.04-08-2010
20090192488SINUS DELIVERY OF SUSTAINED RELEASE THERAPEUTICS - The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.07-30-2009
20100121307Microneedles, Microneedle Arrays, Methods for Making, and Transdermal and/or Intradermal Applications - Embodiments are directed to microneedle array devices for intradermal and/or transdermal interaction with the body of patient to provide therapeutic, diagnostic or preventative treatment wherein portions of the devices may be formed by multi-layer, multi-material electrochemical fabrication methods and wherein individual microneedles may include valve elements or other elements for controlling interaction (e.g. fluid flow). In some embodiments needles are retractable and extendable from a surface of the device. In some embodiments, interaction occurs automatically with movement across the skin of the patient while in other embodiments interaction is controlled by an operator (e.g. doctor, nurse, technician, or patient).05-13-2010
20110196338CLOSURE CONTAINER FOR SINGLE DOSE DISPOSABLE PHARMACEUTICAL DELIVERY SYSTEM - Provided herein is a single dose disposable pharmaceutical delivery apparatus and methods of use and manufacture thereof. One aspect provides a single dose disposable pharmaceutical delivery apparatus that includes a needle hub seal attached to a needle hub and a bladder that can contain a pharmaceutical composition. Another aspect provides for dispensing a pharmaceutical composition from the delivery apparatus by rupturing the needle hub seal and fluidically connecting the needle and the bladder. Another aspect provides manufacturing the delivery apparatus according to steps including attaching a needle hub and a needle hub seal and combining the bladder and the needle hub, thereby forming an apparatus described herein.08-11-2011
20110196337Modular Drug Delivery Device for Administering Discrete Doses of a Medicament - There provided a drug delivery device adapted for providing a plurality of discrete doses of a medicament including a disposable delivery unit (08-11-2011
20090306624DEVICES AND METHODS FOR DELIVERING ACTIVE AGENTS TO THE OSTEOMEATAL COMPLEX - Described here are devices, methods, and kits for treating sinusitis and related respiratory conditions by locally delivering active agents to the osteomeatal complex over a sustained period of time. The devices may be passively fixed within the osteomeatal complex and/or include one or more features that actively fix it within the osteomeatal complex. The devices may optionally include a portion that extends into a sinus ostium, sinus cavity, and/or the nasal passage to deliver an active agent.12-10-2009
20090326511METHOD TO PROTECT THE ESOPHAGUS AND OTHER MEDIASTINAL STRUCTURES DURING CARDIAC AND THORACIC INTERVENTIONS - Devices and methods are disclosed for preventing injury to a target tissue in proximity to the heart. The methods may include the use a device to externally manipulate the heart to move a portion of the heart away from the target tissue. The methods may also include applying therapy to the heart with the device.12-31-2009
20100076400METHOD AND DEVICE FOR PAINLESS INJECTION OF MEDICATION - A method for providing a substantially painless injection of medication into a patient, including inserting an injection needle having an outside diameter greater than 0.20 mm and less than about 0.38 mm, and injecting a medicament through the needle and into the patient at a substantially constant volumetric flow rate of about 0.05 μL/s to about 50 μL/s that provides a painless injection. The method does not require the use of an anesthetic or that the medical personnel to spend a substantial amount of time performing the injection procedure, is relatively simple and inexpensive to perform and operate, and provides a relatively high degree of safety for both the medical personnel and for the patient.03-25-2010
20100076399Fluid dispenser - Dispensing assemblies, methods, and kits of parts for dispensing two separate fluids to an treatment site, including entraining non-atomized flow of a first fluid in an atomized flow of a second fluid, delivering a first fluid upstream from a second fluid, delivering a first fluid and a second fluid with re-shapeable malleable tubes, delivering first and second fluids with releasable connectors maintained by a handle assembly, and kits of parts with angularly offset pockets.03-25-2010
20130085472MICRONEEDLE NASAL DELIVERY DEVICE - The invention is directed to a nasal delivery device comprising one or more microneedles, and to methods of nasally administering a composition with a nasal delivery device comprising one or more microneedles. In certain embodiments, the nasal delivery device comprises a substrate for administration of a composition to the nasal and/or sinus mucosa, wherein the substrate is non-absorbent and comprises one or more microneedles. In some embodiments, the nasal delivery device comprises a reservoir comprising one or more therapeutic agents, wherein the reservoir is in fluid communication with one or more microneedles.04-04-2013
20130079748STEPPED CANNULA - Described herein are cannulas having a stepped exterior. Also described are methods of making and using these cannulas, for example to deliver one or more materials to the central nervous system of an animal.03-28-2013
20130079747DRUG DELIVERY DEVICE - A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocable chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to The device may also be provided with manually control for delivering a bolus dose of drug when necessary.03-28-2013
20130079746INTRODUCER SHEATH WITH THIN-WALLED SHAFT - A thin-walled introducer sheath is described. In some embodiments, the introducer sheath includes structural support components, such as wires, used in connection with a polymeric inner coating, a polymeric outer coating, or both. Further, in some embodiments, the wire components are annealed to reduce cold-work-related stresses and hardness. Use of annealed components may enable a reduction in the thickness of the polymeric outer coating in some applications.03-28-2013
20100145305LOW VOLUME ACCURATE INJECTOR - Substance-administration apparatus is provided, including a housing and a needle couplable to the housing, having a skin-insertion portion 0.3-2.5 mm in length and an outer diameter that is less than 0.23 mm. The apparatus also comprises a dosage regulator coupled to the housing, which regulates a dosage of the substance injected in a single injection through the needle. The dosage is selectable in accordance with a setting of the dosage regulator to be one of a plurality of selectable dosages. The plurality of selectable dosages includes at least one dosage that is less than or equal to 10 ul. The apparatus further includes an injection driver, activatable by a user to drive the substance through the needle. Other embodiments are also described.06-10-2010
20100145304THERMOCHEMICAL ABLATION OF BODILY TISSUE - Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.06-10-2010
20100145303DEVICE FOR DRUG DELIVERY - Delivery of more than one therapeutic fluid as a means to control symptoms of a health conditions is disclosed. More than one therapeutic fluid may be dispensed from more than one reservoir and delivered to a user's body via one or more cannula that penetrate the skin. The therapeutic fluids may be delivered by action of one or more pumping mechanisms that may be controlled by a processor in a portable, ambulatory device. The therapeutic fluids may optionally be insulin and one or more of an amylin analog, pramlintide acetate and an exenatide, and the health condition may optionally be diabetes.06-10-2010
20130035664DUAL CHAMBER MIXING DEVICE FOR A SYRINGE - A mixing device and a retractable syringe comprising same are provided. The mixing device comprises concentric outer and inner barrels that form an outer chamber, the inner barrel having an inner chamber. A mixing plunger is slidably located in the outer chamber. A seal located in the outer chamber is capable of axial movement, in response to depression of the mixing plunger, from a first position in sealing engagement with one or more apertures in the inner barrel to a second position intermediate the apertures and vents in the outer barrel. This allows depression of the mixing plunger to force a first substance from the outer chamber through the apertures to mix with a second substance in the inner chamber. The mixed substance in the inner barrel is then delivered by the syringe with subsequent needle retraction.02-07-2013
20090124997METHODS AND DEVICES FOR IMPROVING DELIVERY OF A SUBSTANCE TO SKIN - A method of delivery of a substance to a human subject's skin comprising deposition into a specific compartment of the skin, wherein the delivery occurs at a controlled rate and pressure. The methods of the invention provide accurate deposition of s pre-selected volume of the substance, e.g., greater than 90% of the pre-selected volume. The methods of the invention encompass varying one or more parameters including but not limited to configurations of the delivery device, volume, pressure, and flow rate of delivery, to enhance the efficacy of delivery of the substance to the human skin. Substances delivered in accordance with the methods of the invention result in a more efficacious deposition of the substance into the targeted compartment, improved delivery performance, i.e., completeness of delivery as measured by quantification of the substance not delivered or the amount of the substance leaked out from the injection site, and enhanced safety as measured by the occurrence of minimal adverse cutaneous events at the site of injection.05-14-2009
20130041346LOW VOLUME ACCURATE INJECTOR - Substance-administration apparatus (02-14-2013
20130041347MEDICAMENT DELIVERY DEVICE - The present invention relates to a medicament delivery device comprising a drive means configured to act on a medicament container for expelling a medicament; a holding means configured to hold said drive means in a pre-tensioned state; an activation means configured to interact with said holding means for releasing said drive means from the pre-tensioned state; wherein the device further comprises feedback means configured to interact both with said holding means and with said drive means for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.02-14-2013
20130041344Medication Delivery Device and Method for Dispensing a Medication - A medication delivery device (02-14-2013
20130041345STERNAL LOCATORS AND ASSOCIATED SYSTEMS AND METHODS - Apparatuses, systems, and methods for sternal locators for placement of an intraosseous device into the sternum of a human patient.02-14-2013
20120265166DEVICES AND METHODS FOR ENHANCING DRUG ABSORPTION RATE - Devices, systems and methods directed to a drug delivery device including a soft subcutaneously insertable cannula are disclosed. Some embodiments of the cannula include an elongated soft tube having a plurality of apertures spaced around and/or along a wall of the elongated soft tube. The plurality of apertures is configured for fluid flow therethrough resulting-in/causing an increase in an absorption rate of the fluid in the body of the user. The drug delivery device can be an insulin pump.10-18-2012
20100042068HYDRAULIC INJECTION SYSTEM AND INJECTION METHOD - Disclosed is an injection system (02-18-2010
20090157041Microneedel-based pen device for drug delivery and method for using same - A system and method is provided for an injectable substance delivery pen comprising a microneedle hub assembly removably engaged with a pen device body which includes a cartridge, a plunger, and a drive mechanism. The hub assembly includes at least one microneedle for intradermal or shallow subcutaneous injection of the contents of the cartridge. The cartridge, plunger and drive mechanism components of the pen body are fabricated of non-compliant and non-compressible materials to allow effective communication of the cartridge contents via the microneedle patient interface.06-18-2009
20100106134Inner Ear Drug Delivery Device and Method - A drug delivery device for the inner ear is described. A drug delivery member for the inner ear without any stimulation electrodes has an intra-cochlear portion that penetrates into the inner ear of the patient and contains a drug eluting polymer material having at least one therapeutic drug which is released over time in a therapeutically effective amount into fluid in the inner ear of the patient.04-29-2010
20100106132DRUG CARTRIDGE FOR DELIVERING A DRUG DEPOT COMPRISING SUPERIOR AND INFERIOR COVERS - A drug cartridge is provided for delivering a drug pellet to a site beneath the skin of a patient, the drug cartridge comprising: two or more chambers, each chamber holding a drug pellet and having a proximal end and a distal end, the proximal end of the chamber having an opening to receive the drug pellet and a plunger, the distal end of the chamber having an opening for receiving the plunger and passage of the drug pellet, superior and inferior locking covers disposed on at least one chamber opening, wherein movement of the plunger to an extended position moves the drug pellet within the chamber of the cartridge out the distal end of the chamber and out of the drug cartridge. Devices that utilize the drug cartridge are also provided.04-29-2010
20100106133DRUG CARTRIDGE FOR DELIVERING A DRUG DEPOT COMPRISING A BULKING AGENT AND/OR COVER - A drug cartridge is provided for delivering a drug pellet to a site beneath the skin of a patient, the drug cartridge comprising: two or more chambers, each chamber holding a drug pellet and having a proximal end and a distal end, the proximal end of the chamber having an opening to receive the drug pellet and a plunger, the distal end of the chamber having an opening for receiving the plunger and passage of the drug pellet, a bulking agent disposed within at least a portion of each chamber, wherein movement of the plunger to an extended position moves the drug pellet within the chamber of the cartridge out the distal end of the chamber and out of the drug cartridge. In some embodiments, instead or with the bulking agent pierceable superior and inferior covers are used to contain the drug pellets.04-29-2010
20090093790METHOD OF FLUID DELIVERY AND CATHETERS FOR USE WITH SAME - A pain management system for the infusion of drug to a wound site includes a pump connected to medical tubing which is connected to an improved infusion catheter for providing uniform delivery of fluid throughout an anatomical region. The infusion catheter is inserted into the body of a patient at a pierce site, spaced from an incision site, and extended to the wound site. The pump causes the drug to flow through the medical tubing, through the infusion catheter and to the wound site. One method by which the infusion catheter is advanced to the wound site includes a guide needle that is placed within an introducer tubing. The needle is pierced through the patient's skin, after which the guide needle is withdrawn and discarded, leaving the introducer tubing in place partially under the patient's skin. The infusion catheter is then threaded through the introducer tubing and advanced to the wound site. The introducer tubing is then withdrawn and the infusion catheter remains in place to provide drug to the wound site. The introducer tubing is preferably peeled off of the infusion catheter and discarded. In accordance with one embodiment of the catheter, the catheter comprises an elongated tube with a plurality of exit holes along an infusion section of the catheter, and an elongated flexible porous member residing within the tube and forming an annular space between the tube and the member. In accordance with other embodiments, the catheter includes a tube having a plurality of exit holes in a side wall of the tube. The exit holes may combine to form a flow-restricting orifice of the catheter. Advantageously, fluid within the catheter flows through all of the exit holes, resulting in uniform distribution of fluid within an anatomical region.04-09-2009
20090124998METHOD FOR DELIVERING THERAPEUTIC OR DIAGNOSTIC AGENTS - An agent delivery device includes an inner tubular body having a proximal end, a sharpened distal end, a delivery lumen extending therebetween, and one or more outlet ports on the distal end communicating with the delivery lumen. The device also includes one or more seals sealing the one or more outlet ports, the one or more seals capable of being melted to allow a fluid to be delivered from the delivery lumen through the one or more outlet ports. The agent delivery device may further include a monopolar or bipolar electrode and/or a radio-opaque marker carried at the distal end of the device. The inner tubular body can be made from a conductive material to thereby allow the inner tubular body to function as an electrode.05-14-2009
20090124996APPARATUS AND METHODS FOR INJECTING HIGH VISCOSITY DERMAL FILLERS - A method includes inserting a distal end portion of a needle of a medical injector into a skin of a body. An energy source operatively coupled to the medical injector is actuated such that a dermal filler is conveyed from the medical injector into the skin through the distal end portion of the needle. The distal end portion of the needle is moved within the skin during the actuating.05-14-2009
20090124995Backer Plate Adapter for a Syringe Plunger - A backer plate adapter (05-14-2009
20100094252SUBCUTANEOUS DELIVERY TOOL - Exemplary embodiments provide subcutaneous implantation tools and methods of implanting a subcutaneous micro-device using the same. Exemplary embodiments provide subcutaneous implantation tools including a syringe body, a dissection body, and a delivery assembly. Additional exemplary embodiments provide methods of implanting a subcutaneous micro-device, including inserting the dissection body of the tool described by the exemplary embodiments into an implantation site, where the dissection body includes a micro-device, and delivering the micro-device.04-15-2010
20120165784AUTOMATIC NEEDLE GUARD - A device for selectively protecting a needle includes an adapter holding the needle and a guard engaging the adapter for relative movement therebetween. Further, the device includes a means for guiding movement between the adapter and the guard. Structurally, the guiding means includes a “V” shaped slot in the guard and a radially-extending boss on the adapter. The boss is received in the slot to limit relative movement between the guard and the adapter. Specifically, in a first position of the device, the boss is in a first leg of the slot and the needle partially extends beyond the guard. In a second position, the boss is held at the apex of the slot and the needle fully extends beyond the guard. In a third position, the boss is in the second leg of the slot and the needle is retracted into the guard to protect the needle.06-28-2012
20090043279MICRONEEDLE ARRAYS FORMED FROM POLYMER FILMS - The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.02-12-2009
20090043278Body-insertable apparatus - A body-insertable apparatus that can reduce the apparatus size and perform projection operation of an injection needle in a power saving manner is provided. A body-insertable apparatus 02-12-2009
20090306623Multiple ratio fluid dispenser - A double syringe delivery system is disclosed for holding a pair of syringes in a manner so as to accommodate the simultaneous activation of the plunger of each syringe in order to effect simultaneous delivery of the contents of each syringe. The delivery system includes a delivery mechanism for delivering the contents of both syringes to a site of application. The delivery system further includes a support member that is positioned between the two syringe bodies. The elongated support member has resilient, C-shaped clamps on one end of the support member. The clamps are designed to be removably clamped onto the applicator so that the syringe barrels will be held together in a parallel manner. The elongated support member further comprises finger grips. A plunger connects the two syringe plungers so that they can also be simultaneously activated.12-10-2009
20090093788Thermal Coefficient Driven Drug Pellet Size For Ophthalmic Injection - A method of injecting a mixture into an eye includes: providing the mixture in a dispensing chamber with an air gap located between the mixture and an interior surface of a dispensing chamber housing, when the mixture and dispensing chamber housing are near room temperature; bringing the dispensing chamber housing and mixture to a temperature range at which the mixture expands and is in a more liquid state; maintaining air in a needle after the mixture expands and prior to an injection; and injecting the air in the needle and the mixture into the eye.04-09-2009
20090093787ERGONOMIC SYRINGE - The present embodiments relate to devices and methods for injection. More specifically, the devices and methods provide an ergonomic aspect. In some embodiments, the devices and methods are especially useful in the administration of low volumes of dermal fillers to a subject.04-09-2009
20130072902MICRONEEDLE ASSEMBLY FORMULATION FOR SKIN TREATMENT - A problem to be solved of the present invention is to provide a drug formulation and a method of administering an active ingredient which allow the active ingredient to be delivered evenly into the site of action in the skin with high efficiency while ensuring stability of the active ingredient over a long time, and which are easily handled and are less stressful for patients. Mean for solving the problem is a microneedle assembly formulation for skin treatment comprising a platform and a plurality of conical or pyramidal microneedles formed on the platform containing a base composed of a bio-soluble and thread-forming polymer substance and an objective substance retained in the base, wherein the objective substance is a substance effective for prevention or treatment of skin senescence, or treatment of skin scar.03-21-2013
20130072901Fixation and Protection of an Implanted Medical Device - Fixation and protective components for use with implantable medical devices, such as access ports and catheters, are disclosed. In one embodiment, a protective sleeve is employed about a catheter so as to distribute compressive loads and ensure patency of the catheter lumen, even in areas prone to pinch-off. A catheter assembly in one embodiment thus comprises an elongate catheter tube that defines at least one lumen. A protective mesh sleeve is disposed about an external portion of the catheter tube so as to cover at least a portion of the longitudinal length of the catheter tube. The protective sleeve is configured to distribute a compressive load on the catheter tube so as to ensure patency of the at least one lumen of the catheter tube.03-21-2013
20130060232AUTOMATIC RECONSTITUTION FOR DUAL CHAMBER SYRINGE - An automatic mixing device, an actuating device removably mounted to the automatic mixing device and a retractable syringe having the automatic mixing device are provided. The actuating device has an initially compressed spring and a trigger member that initiates spring decompression to drive depression of a mixing plunger of the automatic mixing device. A seal located in the outer chamber is capable of axial movement upon depression of the mixing plunger, from a first position in sealing engagement with one or more apertures in an inner barrel to a second position intermediate the apertures and vents in an outer barrel. This allows depression of the mixing plunger to force a first substance from the outer chamber through the apertures to mix with a second substance in an inner chamber of the inner barrel. The mixed substance in the inner barrel is then delivered by the syringe with subsequent needle retraction.03-07-2013
20130060233INSERTION MECHANISM FOR A DRUG DELIVERY PUMP - An insertion mechanism for a drug pump includes an insertion mechanism housing; a manifold guide; an insertion biasing members initially held in an energized state; a retraction biasing member and a hub connected to a proximal end of a needle, wherein the retraction biasing member is held initially in an energized state between the hub and the manifold guide; and a manifold having a septum and a cannula, wherein the annular space between the septum and the cannula defines a manifold header. The needle and cannula are inserted into the body of a user by the insertion biasing member(s), after which only the needle is retracted. Retraction of the needle may open a fluid pathway from the manifold header to the body through the cannula. A drug delivery pump includes an activation mechanism, a drive mechanism, a fluid pathway connection, and the insertion mechanism. Assembly and operation methods are provided.03-07-2013
20130060231AUTO-INJECTOR FOR RETRACTABLE PREFILLED SYRINGE - An actuation mechanism for an automatic injector includes a first actuation spring, a first actuation pill, a second actuation spring, and a second actuation pill. In an initial configuration the first actuation spring resides in a compressed, energized state substantially within an upper portion of first actuation pill and the second actuation spring resides in a compressed, energized state between the first actuation pill and the second actuation pill. An automatic injector includes a housing, an activation mechanism, an actuation mechanism, and a syringe cartridge having a plunger and a needle assembly. A retractable syringe may be utilized as a syringe cartridge, such as a prefilled retractable syringe with integrated safety features which retract the needle after use. The automatic injector may be utilized to inject the needle, deliver a drug treatment, and activate retraction of the needle. Methods of assembly and operation are also provided.03-07-2013
20130060230INJECTABLE FILLERS FOR AESTHETIC MEDICAL ENHANCEMENT AND FOR THERAPEUTIC APPLICATIONS - The present invention relates to a biocompatible injectable filler composition comprising calcium phosphate particles having a porosity of about 10% to about 90%, a BET surface area of about 1 m03-07-2013
20130060229DEVICES, SYSTEMS, AND RELATED METHODS FOR DELIVERY OF FLUID TO TISSUE - A fluid delivery system including a first balloon and a second balloon at least partially positioned within the first balloon, wherein the second balloon has an inner surface, an outer surface, and at least one micro-needle extending outwardly from the outer surface of the second balloon. The delivery system can further include a fluid source in communication with at least one of the micro-needles of the second balloon.03-07-2013
20120226260METHODS AND DEVICES FOR DRUG DELIVERY TO OCULAR TISSUE USING MICRONEEDLE - Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.09-06-2012
20120116349Medicated Module with Premix Medicament - A medicated module (05-10-2012
20120116348LIQUID MEDICINE INJECTION AMOUNT ADJUSTING METHOD, LIQUID MEDICINE INJECTION AMOUNT ADJUSTING APPARATUS, AND LIQUID MEDICINE INJECTING SYSTEM - In a liquid medicine injecting system, an open route is formed in which a liquid medicine flows from a container that contains the liquid medicine to a blood vessel of a biological body via a micro-pump, a flow volume sensor, and a tube. A back pressure from the biological body directly operates against the micro-pump via the open route. When the flow volume of the liquid medicine is constant, power of the micro-pump has a constant relationship with the back pressure. The flow volume of the liquid medicine is adjusted to be a target volume by controlling the power of the micro-pump, and the power of the micro-motor is monitored. An abnormal injecting state of the liquid medicine caused by such as pulling out of an injection needle from the biological body is immediately detected with high accuracy based on the monitored result of the power of the micro-pump.05-10-2012
20090036870INFUSION MEDIUM DELIVERY DEVICE AND METHOD WITH DRIVE DEVICE FOR DRIVING PLUNGER IN RESERVOIR - A delivery device includes first and second housing portions that selectively engage and disengage. A reservoir on one housing portion operatively engages a drive device and/or a needle inserting device on the other housing portion. Upon proper engagement of the housing portions, the reservoir operatively couples to the drive device and/or the needle inserting device. A first magnet on the first housing portion and a second magnet (or a magnetically-attractive material) on the second housing portion are positioned to magnetically interact with each other, upon operative engagement of the housing portions. A third magnet on the second housing portion may be opposed to the first magnet to help align the housing portions for connection. A magnet-responsive device may be on one or both housing portions to detect alignment and/or connection of the housing portions.02-05-2009
20100004626INTRAOSSEOUS DEVICE AND METHODS FOR ACCESSING BONE MARROW IN THE STERNUM AND OTHER TARGET AREAS - Apparatus and methods are provided to access bone marrow at various target areas. Such apparatus may include an intraosseous device operable to penetrate bone at a selected target area and a depth limiter operable to control depth of penetration of the intraosseous device into bone and associated bone marrow. A manual driver and a guide may be included to optimize optimum insertion of the intraosseous device at a selected insertion site on a sternum.01-07-2010
20130165902MICRONEEDLE ARRAY APPLICATOR AND METHOD FOR APPLYING A MICRONEEDLE ARRAY - A microneedle array applicator is configured to apply a microneedle array in cosmetic and medical applications. The microneedle array applicator has a holding apparatus configured to define detachable holding of a microneedle array comprising a planar substrate. The microneedle array applicator also has a drive mechanism for driving the microneedle array in a first direction perpendicular to the planar substrate and in a second direction parallel to the planar substrate. A method for applying a microneedle array includes the microneedle array applicator enabling safe breaking off of the microneedles, optionally laden with an active ingredient, in the skin.06-27-2013
20080294143BODY-INSERTABLE DEVICE AND LIQUID MEDICINE INJECTION METHOD - A body-insertable device is introduced into a desired part in a body for injecting a liquid medicine stored in a casing into the desired part. The body-insertable device includes a projecting portion which projects an injection needle injecting the liquid medicine toward the desired part; a detecting unit which detects a position relation between a biological tissue surface in the desired part and the injection needle; and a control unit. The control unit controls an amount of projection of the injection needle according to the position relation detected by the detecting unit, and controls a puncture depth of the injection needle from the biological tissue surface.11-27-2008
20080294142Removable Controller for an Infusion Pump - Some embodiments of an infusion pump system includes a controller device that is configured to removably attach to a pump device in a manner that provides a secure fitting, an overall compact size, and a reliable electrical connection. In particular embodiments, the controller device can be secured to the pump device in a generally side-by-side arrangement. The compact size can enhance the discreteness and portability of the infusion pump system.11-27-2008
20110034902INJECTION DEVICE FOR DELIVERING A FIXED DOSE OF LIQUID DRUG - An injection device (02-10-2011
20120130345RENAL NERVE STIMULATION METHOD FOR TREATMENT OF PATIENTS - A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug infusion or electrostimulation. Apparatus can be permanently implanted or catheter based.05-24-2012
20120065618Delivery system for injection through zone of body - A dispensing device which disperses medicate through a needle across a zone within a body with zero pressure differential. The device includes a needle which is, during use, becomes encapsulated within a tubular needle-receiving member, a therapeutic agent reservoir in fluid communication with the needle, positioned within said housing, and in communication with the needle, a second reservoir, a reservoir-connecting conduit in communication with the therapeutic agent reservoir, a fluid drive in communication with the fluid in the second reservoir and in communication with said reservoir-connecting conduit, and a linear drive attached to said needle or to said needle-receiving member.03-15-2012
20130023851System and method for administering medicaments to a patient - The invention relates to a system and method for administering medicaments to a patient. The system comprises: a mobile medicament container with a liquid medicament; an identification-element-generating device for generating a first identification element with first data relating to the patient, medication and/or treatment, in order to apply this identification element to the medicament container; a reading device for reading the first data; a delivery device for delivering the medicament to the patient from the medicament container inserted into the delivery device, wherein the reading device is suitable for reading second data provided on/in a second identification element assigned to the patient and connected to the delivery device, and a control device within the delivery device sends a first control signal for activating the delivery process to at least one of a plurality of delivery units of the delivery device if the first and second data at least partially match.01-24-2013
20100249748NEEDLE SHIELD FOR INJECTIONS - A needle shield for hiding a needle from a patient during an injection is disclosed. The needle shield comprises an attaching portion for attaching the needle shield to a syringe and an opaque collapsible element extending from the attaching portion, the collapsible element having an orifice extending therethrough and being of a sufficient length to conceal a needle from view when the needle is disposed in the orifice, and wherein the collapsible element collapses and conceals the needle as the needle is inserted into a patient's skin and expands to retain its original shape as the needle is withdrawn from the patient's skin so that the patient does not see the needle during an injection.09-30-2010
20100249747Transdermal venous access locking solution - Compositions and methods of employing compositions in flushing and coating medical devices are disclosed. The compositions include combinations of a chelating agent, anticoagulant, or antithrombotic agent, with a C09-30-2010
20110172640Medical injector with ratcheting plunger - A medical injector has a body with a displaceable plunger. The plunger includes a plurality of spaced-apart ratchet teeth disposed along the length thereof. At least one indexer is provided to engage the plunger, wherein the indexer is configured to allow the plunger to displace distally toward a distal end of the body but not proximally toward a proximal end of the body. The medical injector also includes an actuator having an engagement portion formed to engage one or more of the ratchet teeth. The actuator is displaceable to a ready state, the engagement portion being displaced proximally relative to the plunger with the actuator being displaced to the ready state. The indexer prevents proximal movement of the plunger, thereby allowing the engagement portion to bypass one or more of the ratchet teeth with the actuator being displaced to the ready state. In addition, the actuator is displaceable from the ready state to cause actuation of the medical injector. The displacement from the ready state causes distal displacement of the engagement portion with the engagement portion engaging one or more of the ratchet teeth and causing distal displacement of the plunger with the engagement portion.07-14-2011
20090093789Method of Delivering A Rate And Temperature - Dependent Substance Into The Eye - A method of injecting a mixture into an eye includes: providing the mixture in a dispensing chamber with an air gap located between the mixture and an interior surface of a dispensing chamber housing, when the mixture and dispensing chamber housing are near room temperature; bringing the dispensing chamber housing and mixture to a temperature range, other than near room temperature, at which the mixture expands and is in a more liquid state; maintaining air in a needle after the mixture expands and prior to an injection; selecting a drug release rate; and injecting the mixture so as to form a shape with a surface area that results in the selected drug release rate.04-09-2009
20120239000Drug Delivery Method Via Brain Extracellular Space and a Device Thereof - The present invention relates to a method for drug delivery via brain extracellular space (ECS). It includes putting head of patient in an imaging apparatus; generating dynamic images of the brain via the imaging apparatus; delivering drugs into brain ECS of the patient according to the dynamic images and the drugs get to the therapeutic target by simple diffusion along concentration gradient. The present invention also relates to a device for drug delivery via brain ECS. Basing on the self-diffusion delivery (SDD) of drugs in brain ECS, the present invention can deliver drug into the ECS of the brain's relatively safe area in low speed, with small amounts of doses and without extra stress. Therefore, the present invention can reduce delivery time and dose of drugs, relieve injection pressure, decrease damages on normal brain tissue, and reduce the cost of treatment observably.09-20-2012
20090204103INJECTION DELIVERY SYSTEM - An injection delivery system for automatically injecting fluid into an injection site includes at least one support element and a carriage moveably mounted to the at least one support element so that the carriage can move linearly relative thereto. The carriage has a support structure for removably receiving and carrying a syringe assembly for movement with the carriage, and a carriage actuator is operable to cause such linear movement of the carriage. A plunger actuator is carried by the carriage so as to move with the carriage, and is adapted to be operably coupled to a syringe plunger for causing linear movement of the syringe plunger within a syringe barrel. The carriage actuator and plunger actuator include respective inputs for receiving movement instructions, and may be coupled to an electronic controller that provides such instructions.08-13-2009
20110301570KIT FOR INJECTING LIQUID INTO A PATIENT AND ASSOCIATED PREPARATION METHOD - This kit includes an injection device comprising a needle having a free end pricked into a septum of an implantable chamber and an intermediate tubing connected downstream to the needle. The kit includes an upstream conduit having an upstream end connected to a liquid dispensing apparatus and a downstream end removably connected to the intermediate tubing. The pressure loss through the upstream conduit is greater than 25% of the total pressure loss taken between the upstream end of the upstream conduit and the free end of the needle, upon injecting liquid through the upstream conduit and the injection device.12-08-2011
20120109103DEVICES AND METHODS FOR CONTROLLED-DEPTH INJECTION - Devices and methods for simultaneous injection or delivery of two or more substances from separate syringes. The syringes are loaded into a device that has a handle and a screw driven mechanism for simultaneously depressing the plungers of the syringes. The user grasps the handle and positions the device. Thereafter, the screw mechanism is used to simultaneously advance the plungers of the syringes thereby simultaneously expelling the substances from the syringes.05-03-2012
20110288525OCULAR SURGICAL PROCEDURE - Aspects of forming a wound-conforming pressure seal in the eye, such as upon completion of an ocular surgical procedure, are described herein. Forming the seal includes introducing a plug member into an opening formed in the eye to block vitreous from exiting from the eye through the opening. Consequently, the seal is operable to substantially reduce or eliminate hypotony (i.e., lowering of intraocular pressure below safe levels) and/or endophthalmitis (i.e., infections to the eye).11-24-2011
20110288528EXTRACTABLE FILLER FOR INSERTING MEDICINE INTO VERTEBRAL BODY - An extractable device is used to insert a medicinal filling into a vertebral body. The device comprises a filling member and a pasty medicine. The filling member is made of a flexible and permeable wall and is provided with a holding portion and an injection port via which the pasty medicine is injected into the holding portion after the filling member is inserted into the vertebral body. The holding portion is provided with an opening which is releasably lashed by one end of one or more threads so as to make the opening leakproof. Upon completion of solidification of the pasty medicine in the holding portion of the filling member, other end of the thread is pulled to unlash the opening of the holding portion, thereby enabling the filling member to be extracted from the vertebral body so as to leave only the medicine in the vertebral body.11-24-2011
20110288527DEVICE AND METHOD FOR DRUG DELIVERY - A therapeutic treatment device, system and method for improving administration of a temperature sensitive drug into a tissue on the body of a patient at a drug injection site are disclosed. The device includes a treatment element with a controllable heating element in temperature communicative contact with the tissue adjacent to the drug injection site. The controllable heating element is configured to heat the tissue adjacent to the drug injection site to a controllable temperature but does not heat the injected drug above a predetermined limiting temperature, above which degradation of the injected drug may occur.11-24-2011
20090171314MOLDED ARTICLES COMPRISING MICRONEEDLE ARRAYS - A molded article comprising at least one chain of microneedle arrays wherein adjacent arrays in the chain are interconnected by integrally formed runners. Such a molded article may further comprise two or more chains of microneedle arrays, wherein adjacent chains are interconnected to each other by integrally formed runners. Also, methods of making molded articles and positioning them for delivery to a patient.07-02-2009
20120191064METHODS AND APPARATUS FOR SUB-RETINAL CATHETERIZATION - Devices and methods are provided for access to the sub-retinal space that lies between the retina and the choroid in order to introduce therapies to the retina and more specifically to the sensory retina and RPE, particularly in the region of the macula. The devices comprise a catheter that incorporates advantageous size, flexibility and tip features to properly, accurately and atraumatically access the sub-retinal space. Ancillary devices to assist in placing catheters into the sub-retinal space are also provided. The catheter devices incorporate a lumen for delivery of therapeutic substances or devices into the eye.07-26-2012
20120191067Injection Device with Sealed Luer Fitting - The invention relates to an injection device (07-26-2012
20090287181CATHETER/FILAMENT STYLE DEVICE AND METHODS FOR TREATMENT OF WOUNDS BENEATH THE SURFACE OF THE SKIN - A reduced pressure treatment system includes a filament delivery conduit having a distal end positioned at a subcutaneous tissue site of a patient and a proximal end positioned extracorporeal to the patient. A continuous filament is positioned in the filament delivery conduit such that one end of the continuous filament extends from the proximal end of the filament delivery conduit and another end of the continuous filament extends from the distal end of the filament delivery conduit. The continuous filament forms a filament mass adjacent the tissue site. A reduced pressure delivery conduit is adapted to fluidly communicate with a reduced pressure source and the filaments mass to deliver a reduced pressure to the tissue site through the filament mass.11-19-2009
20110295232Device and Method for the Automatic Initiation of an Injection - A system and method to automatically initiate an injection procedure of a medicament into a patient. In the system, a delivery assembly includes an injector for infusing the medicament into the patient. Further, the system includes a monitor for detecting a parameter characteristic of the procedure, for instance, a pressure indicative of a partial vacuum between the injector and the injection site, a pressure exerted by the patient against the delivery assembly, a conductance, a capacitance, or an optical blood reading. Also, the system includes a timer for determining compliance of the parameter within a predetermined range during a first time interval. In response to the timer, an actuator initiates the injection procedure at the expiration of the first time interval. Further, the actuator may stop the injection procedure if the parameter is outside the predetermined range during a second time interval.12-01-2011
20110295231EXTRACTABLE FILLER FOR INSERTING MEDICINE INTO ANIMAL TISSUE - An extractable device is used to insert a medicinal filling into an animal tissue. The device comprises a filling member and a pasty medicine. The filling member is made of a flexible and permeable wall and is provided with a holding portion and an injection port via which the pasty medicine is injected into the holding portion after the filling member is inserted into the animal tissue. The holding portion is provided with an opening which is releasably lashed by one end of one or more threads so as to make the opening leakproof. Upon completion of solidification of the pasty medicine in the holding portion of the filling member, other end of the thread is pulled to unlash the opening of the holding portion, thereby enabling the filling member to be extracted from the animal tissue so as to leave only the medicine in the animal tissue.12-01-2011
20110295230FLUID TRANSFER DEVICE AND AN ACTIVE SUBSTANCE CARTRIDGE FOR THE FLUID TRANSFER DEVICE, AND A METHOD FOR CONTROLLING THE PRESSURE AT WHICH AN ACTIVE SUBSTANCE IS DELIVERED TO A SUBJECT FROM A FLUID TRANSFER DEVICE - A micro-needle device comprising an active substance layer (12-01-2011
20120191066Prefilled Cannula Assembly - A method and system for proving a cannula arrangement (07-26-2012
20120191065INTRADERMAL PEN ADAPTER - An intradermal injection adapter includes a body having a longitudinal axis and a central portion located distally relative to the body along the longitudinal axis. The central portion has a cannula channel therethrough extending generally parallel to the longitudinal axis. A cannula within the cannula channel has a sharpened tip for injection into a patient and a sharpened opposite proximal end for injection into a pen injector. A distal protrusion has a first skin contacting surface extending generally parallel to the longitudinal axis. The first skin contacting surface is spaced from the cannula such that a distal portion of the cannula extends generally parallel to the first skin contacting surface.07-26-2012
20090099544METHODS AND SYSTEMS FOR CONTROLLED DEPLOYMENT OF NEEDLES IN TISSUE - Needles are deployed in tissue under direct ultrasonic or other imaging. To aid in deploying the needle, a visual needle guide is projected on to the image prior to needle deployment. Once the needle guide is properly aligned, the needle can be deployed. After needle deployment, a safety boundary and treatment region are projected on to the screen. After confirming that the safety boundary and treatment regions are sufficient, the patient can be treated using the needle.04-16-2009
20090099545Self-contained portable apparatus for administration of a drug solution - A self-contained portable apparatus for administration of a drug solution is disclosed, comprising: a housing having an enclosure for receiving a flexible pouch containing a drug solution, the output of which is connectable to a conduit for delivering said drug solution to a recipient. A pressurization system is arranged for providing a constant and controllable gas pressure to the housing, wherein a controllable pressure is obtained for a controllable delivery of the drug solution. The pressurization system comprises: a pressure source for delivering positive pressure gas; a pressure accumulation tank connected to said source and to said second chamber, arranged to provide a positive pressure reservoir; a one-way valve arranged between said pressure source and said pressure accumulation tank, enabling gas to flow solely in the direction from the pressure source to the pressure accumulation tank; and a mechanical pressure regulator arranged between said pressure accumulation tank and said housing. Hereby, an extremely stable and well controllable output pressure and output flow is obtainable.04-16-2009
20090149830Intelligent needle technology for acupuncture and injection of cosmetic preparations subcutaneously - Intelligent needles comprise a needle for insertion into the skin to deposit a substance that causes plumping of the skin. The penetration depth of the needle may be adjusted automatically in conjunction with a sensor mechanism that determines a depth the needle can penetrate without contacting blood vessels. Methods of making and using the same for acupuncture and subcutaneous injection are also provided.06-11-2009
20100268190Medical device to be used by a patient - A medical device to be used by a patient, having release means for administering a drug, in particular subcutaneously, and lockable triggering means for triggering the administration of the drug, characterized by telecommunication means, which are connected to the lockable triggering means in order to activate the triggering means in response to the reception data from a remote unit. The device according to the invention in particular assists in the self-injection of therapeutic agents by a patient and reduces the risk of an improper application.10-21-2010
20090299328Injection device for soft-tissue augmentation fillers, bioactive agents and other biocompatible materials in liquid or gel form - Described herein are injection devices capable of automatically injecting substances into the soft tissue of a patient. The devices can inject low to high viscosity materials at predetermined, user selected injection rates, allowing the operator more control than a traditional syringe. The devices can allow mixing of more than one substance and/or reconstitution of a solid substance for injection. The injection devices described herein can allow the operator to easily inject one or more low to high viscosity liquid or gel soft-tissue augmentation fillers, one or more drugs, one or more other biocompatible materials, or combinations thereof.12-03-2009
20120035584Method and Apparatus for Delivering a Lead to a Heart - A method and apparatus for creating and accessing an anatomic space between a heart and a pericardial sac. The apparatus includes a catheter having a cryoadhesion member situated on the distal tip of the catheter. The cryoadhesion member is utilized to adhere to the pericardial sac and to retract the sac to create a tent like structure. The catheter allows introduction of an instrument to access the pericardial sac by puncture. The access to the pericardial sac allows delivery of a device, a drug, a biologic or other substance to the heart or the space around the heart.02-09-2012
20100036362Injection System with Hidden Needles - An auto-injector confines all functional components inside an enclosed housing, to keep its needle out-of-sight, at all times. Within the housing, a needle holder positions a needle at a location. A drive mechanism then simultaneously engages the needle with a fluid source and accelerates it with a predetermined momentum for insertion into a patient. After fluid delivery, the withdrawn needle is moved to storage within the housing for subsequent disposal.02-11-2010
20110270223Reconstituting Infusion Device - A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.11-03-2011
20100137831METHODS AND DEVICES FOR INTRADERMAL INJECTION - Devices and methods for intradermal (ID) administration of diagnostic and therapeutic agents, vaccines and other compounds into the dermal layer of the skin are disclosed. The devices and the methods simplify the ID injection process and increase the consistency of the placement of the needle tip in the dermal space close to the skin surface allowing for a shallow cannula placement in the dermis. Furthermore, the devices and methods broaden the number of sites suitable for ID injection and make the ID injection possible with limited training.06-03-2010
20100137830MEDICATION DELIVERY DEVICE COMPRISING A PLURALITY OF RESERVOIRS - The present invention relates to a medication delivery device for delivering a set dose of medicament, the medication delivery device comprising pump means having first and second pump chambers. The first pump chamber is adapted to transfer medicament from a first collapsible reservoir to an outlet arrangement, said outlet arrangement being in fluidic communication with an associated hypodermic needle. The second pump chamber is adapted to transfer substance from a second reservoir to the outlet arrangement, wherein the first pump chamber is adapted to deliver the set dose of medicament during one or more pump strokes, the stroke volume(s) of said one or more pump strokes being variable.06-03-2010
20120109104NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS - A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.05-03-2012
20120109102CANNULATED SYRINGE - A set of instruments configured to deliver a therapy to a bone can include a cannulated syringe. The cannulated syringe can extend along a longitudinal axis between a proximal and a distal end. The cannulated syringe can have an inner tube and an outer tube that are interconnected at the distal end as a single fixed unit. A first cannulation can be formed along the longitudinal axis of the cannulated syringe within the inner tube and a second cannulation can be formed within an annular space between the inner and outer tubes. The outer tube can define an opening through a sidewall thereof. The cannulated syringe can be closed from fluid communication between the inner and outer tubes.05-03-2012
20110196339AUTOMATIC INJECTION DEVICE FOR ADMINISTERING A FIXED DOSE - An injection device for administering a substance, including a housing, a plunger rod which can be moved relative to the housing, at least one retaining element associated with the rod to hold the rod relative to the housing, and a displaceable locking sleeve which can be displaced relative to the housing from one position in which the sleeve holds the at least one retaining element in a retaining position to a second position in which the at least one retaining element is released.08-11-2011
20080269718Method for pressure mediated selective delivery of therapeutic substances and cannula - Methods and devices are disclosed for selective delivery of therapeutic substances to specific histologic or microanatomic areas of organs. Introduction of the therapeutic substance into a hollow organ space (such as an hepatobiliary duct or the gallbladder lumen) at a controlled pressure, volume or rate allows the substance to reach a predetermined cellular layer (such as the ephithelium or sub-epithelial space). The volume or flow rate of the substance can be controlled so that the intralumenal pressure reaches a predetermined threshold level beyond which subsequent subepithelial delivery of the substance occurs. Alternatively, a lower pressure is selected that does not exceed the threshold level, so that delivery occurs substantially only to the epithelial layer. Such site specific delivery of therapeutic agents permits localized delivery of substances (for example to the interstitial tissue of an organ) in concentrations that may otherwise produce systemic toxicity. Occlusion of venous or lymphatic drainage from the organ can also help prevent systemic administration of therapeutic substances, and increase selective delivery to superficial epithelial cellular layers. Delivery of genetic vectors can also be better targeted to cells where gene expression is desired. The access device comprises a cannula with a wall piercing tracar within the lumen. Two axially spaced inflatable balloons engage the wall securing the cannula and sealing the puncture site. A catheter equipped with an occlusion balloon is guided through the cannula to the location where the therapeutic substance is to be delivered.10-30-2008
20080269717Method of deformity correction in a spine using injectable materials - A method is disclosed for increasing the stiffness of an intervertebral disc between vertebral bodies. The method includes providing a syringe with a needle approximately in the range of 16 to 25 gauge; providing a material having a first stage with a first viscosity adapted to flow through the needle, the material having a second stage with a second viscosity greater than the first viscosity, the second stage material having a stiffness in a range of 1.0-5.0 MPa; testing the annulus fibrosus of the disc to ensure that the annulus fibrosus has sufficient continuity so as to retain the first flowable stage material when subsequently injected into the disc; inserting the needle into the annulus fibrosus; injecting the first stage material into the disc; and permitting the first stage material to become the second stage material so as to form a load bearing implant in the disc.10-30-2008
20080269715Use of an Adhesive as an Intestinal Barrier for Bariatrics - An apparatus for achieving weight loss in a patient is disclosed. The apparatus has a barrier material and an applicator for dispensing the barrier material about the intestine. An injector is used to place the barrier material to block nutrient transfer from the intestine into the blood stream. The barrier material is a polymerizable adhesive that can be injected interstitially between layers of the intestine, or injected into vascular structures to partially block the flow of blood to the nutrient absorbing layers.10-30-2008
20110172639DEVICE AND METHOD FOR DELIVERY OF MICRONEEDLE TO DESIRED DEPTH WITHIN THE SKIN - A device for delivering a drug into the skin of a subject is provided. The device includes a drug reservoir and a microneedle having a tip, a length, and a tip sharpness. The microneedle is coupled to the reservoir. The device includes a microneedle actuator coupled to the microneedle configured to drive the microneedle into the skin of the subject upon activation. The tip sharpness and the actuator allow the microneedle to pass through an outer layer of the skin upon activation, and the length is limited such that the tip does not extend past a desired depth below the surface of the skin of the subject, wherein the desired depth is located in the papillary dermis or the reticular dermis.07-14-2011
20110172638DRUG DELIVERY DEVICE INCLUDING MULTI-FUNCTIONAL COVER - An apparatus for delivering a drug to a subject is provided. The apparatus includes a housing, a microneedle coupled to the housing and configured to extend from the housing when activated, an activation control coupled to the housing and an outer shell. The outer shell includes a top wall having an inner surface and a sidewall extending from the top wall, the sidewall having an inner surface. The outer shell includes a first attachment structure configured to attach to the housing. The outer shell covers the activation control when the first attachment structure is attached to the housing. The outer shell includes a second attachment structure configured to attach to the housing. The outer shell covers the activated microneedle when the second attachment structure is attached to the housing.07-14-2011
20110172636INJECTION APPARATUS AND SPECIAL NEEDLE FOR MAKING AN INJECTION AT A PREDETERMINED DEPTH IN THE SKIN - An injection apparatus for making an injection at a predetermined depth in skin comprises: a skin positioning member, an injection needle (07-14-2011
20090281520Ocular Implantation Device - An ocular implantation device comprises a housing having a longitudinal axis, a needle configured to receive an implant, and a plunger and a rod operatively coupled together. The plunger and the rod are disposed in the housing and are collectively, translationally moveable along the longitudinal axis of housing. The rod is configured to be receivable within at least a portion of the needle to enable the rod to move an implant therethrough. An actuator is operatively engaged with the plunger such that movement of the actuator in a direction aligned with the longitudinal axis of the housing results in translational movement of the plunger and the rod along the longitudinal axis of the housing in order to deliver the implant through the needle to a target site. An alternative embodiment of the device uses a retractable needle to deliver the implant.11-12-2009
20080287908Ethmoidotomy System and Implantable Spacer Devices Having Therapeutic Substance Delivery Capability for Treatment of Paranasal Sinusitis - Substance delivering spacer devices may comprise expandable reservoirs that are implantable in paranasal sinuses and other cavities, openings and passageways of the body to maintain patency and to provide sustained local delivery of a therapeutic or diagnostic substance. Also provided are sinus penetrator devices and systems for performing ethmoidotomy procedures or for creating other openings in the walls of paranasal sinuses or other anatomical structures.11-20-2008
20080269716MEDICAL DEVICE IMPLANTATION - The disclosure is directed to a method for implanting a medical device proximate to a target tissue site within an occipital region of a patient, such as proximate to an occipital nerve or a trigeminal nerve. The method comprises introducing an implant tool into a patient to define an insertion path to the target tissue site. The implant tool includes a shape memory cannula and a malleable needle at least partially disposed within an inner lumen of the cannula. The shape of the needle may be changed to accommodate different anatomical structures/features of the patient. Upon withdrawal of the needle from the cannula, the cannula may change shape, thereby changing the shape of the insertion path.10-30-2008
20080208162Device and Method For Thermophoretic Fluid Delivery - A method and device for thermolphoretic fluid or drug delivery through the creation of a thermal gradient in the skin. The device includes a heat generating mechanism capable of transdermal delivery of a beneficial agent, an insulating portion coupled with the heat generating mechanism, a cold generating mechanism coupled with the insulating portion, and wherein the heat generating mechanism and the cold generating mechanism create a thermal potential across dermal regions. The method includes generating a hot dermal region and transdermally delivering a beneficial agent, insulating, generating a cold dermal region, and creating a thermal potential across the hot dermal region and the cold dermal region.08-28-2008
20080208165METHODS, SYSTEMS, AND KITS FOR IMPLANTING ARTICLES - Methods, systems, and kits for subcutaneously implanting articles, such as drug inserts and reservoirs. The methods rely on percutaneously forming a tissue tract and radially dilating the tract to a diameter which permits introduction of the article. By fully expanding the lumenal diameter of the tissue tract prior to introduction of the article, damage to the article resulting from passage through a partially expanded tissue tract can be avoided. In the exemplary embodiment, a radially expandable sleeve is first percutaneously introduced to the subcutaneous target site. An assembly of a cannula and dilator is then passed through the sleeve, effecting radial expansion. The dilator is removed and the article is then introduced through a lumen of the cannula.08-28-2008
20080208164METHODS FOR THE TREATMENT OF ANAL INCONTINENCE - The present invention relates to methods of preventing or treating anal incontinence comprising injecting muscle-derived cells into a site of interest via an injection device, where the injection site of interest is, or is adjacent to, muscle-tissue providing for anal continence.08-28-2008
20090112180Method for Inserting a Medical Device Flexible Conduit into a User's Target Site - A method for inserting a medical device flexible conduit into a user's target site includes adhering a medical device to a user with the medical device including a medical device flexible conduit and an insertion mechanism. Moreover, the medical device flexible conduit has an elongated Nitinol strip with a distal end, a proximal end, a longitudinal axis running from the distal end to the proximal end, a sharp head extending from the distal end, and a channel etched therein. In addition, the channel is dispositioned along the longitudinal axis. The medical device flexible conduit also includes a flexible tube at least partially jacketing the elongated Nitinol strip between the distal end and the proximal end, the channel and flexible tube defining a conduit. The insertion mechanism is configured to insert a portion of the flexible conduit including the sharp head into a user's target site such that the conduit provides fluid communication to the target site. The method also includes inserting the medical device flexible conduit into the user's target site.04-30-2009
20090275916Medication Delivery Device - The present invention relates to a medication delivery device, to dosing mechanisms suitable for use in such medication delivery device, in particular in pen-type injectors, preferably having a dose setting member and a drive device enabling the dose setting and the administration of a medicinal product from a multi-dose medication cartridge, to methods using such device, and to methods of manufacturing and assembly of such device.11-05-2009
20090275914Medication Delivery Device - The present invention relates to a medication delivery device, to dosing mechanisms suitable for use in medication delivery devices, in particular in pen-type injectors, preferably having dose setting means and a drive device enabling the administration of a medicinal product from a single- or multi-dose medication cartridge, to a use of such device, and to a method of manufacturing or assembling such device.11-05-2009
20090275915Medication Delivery Device - The present invention relates to a medication delivery device, to dosing mechanisms suitable for use in medication delivery devices, in particular in pen-type injectors, preferably having dose setting means and a drive device enabling the administration of a medicinal product from a multi-dose medication cartridge, to a use of such device, and to a method of manufacturing or assembling such device.11-05-2009
20110172637DRUG DELIVERY DEVICE INCLUDING TISSUE SUPPORT STRUCTURE - A drug delivery device for delivering a drug to a subject includes a microneedle configured to facilitate delivery of the drug to the subject. The microneedle includes a tip portion and is moveable from an inactive position to an activated position. When the microneedle is moved to the activated position, the tip portion of the microneedle is configured to penetrate the skin of the subject. The drug delivery device includes a tissue support structure that includes a channel and an engagement element. The channel has a first end and a second end and is in axial alignment with the microneedle. At least the tip portion of the microneedle extends past the second end of the channel in the activated position. The engagement element is positioned adjacent to the channel, and the engagement element is configured to engage with the skin of the subject such that the engagement element resists downward deformation of the skin caused by the microneedle as the microneedle moves from the inactive position to the activated position.07-14-2011
20090118699Systems and methods for treating obesity and other gastrointestinal conditions - Systems and methods affect tightening of the pyloric sphincter and/or serve to mediate or moderate receptive relaxation of muscles in the stomach, to treat or mitigate various physiologic conditions, such as obesity, biliary reflex, GERD, and/or Barrett's esophagus. The systems and methods may be used as either a primary treatment modality, or applied as a supplementary treatment before, during or after a primary intervention.05-07-2009
20120289932DEVICE AND METHOD FOR COMBINING A TREATMENT AGENT AND A GEL - A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.11-15-2012
20110270221Nanopatterned Medical Device with Enhanced Cellular Interaction - Disclosed are nanotopography-based methods and devices for interacting with a component of the dermal connective tissue. Devices include structures fabricated on a surface to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Microneedles may be beneficially utilized for delivery of an agent to a cell or tissue. Devices may be utilized to directly or indirectly alter cell behavior through the interaction of a fabricated nanotopography with the plasma membrane of a cell and/or with an extracellular matrix component.11-03-2011
20100298808METHOD AND A DELIVERY DEVICE FOR ADMINISTERING AN ACTIVE SUBSTANCE TO A SUBJECT - A delivery device (11-25-2010
20080249502Apparatus and method of safe placement of bulking materials for gastroscopic vagus nerve bulking to reduce appetite and to effect weight loss - An apparatus for grasping the fundal mucosa and method for delivery of and safe placement of a tissue bulking agent adjacent to the right and left vagus nerve trunk in the lesser curvature of the of the stomach or at the gastroesophageal junction to compress the vagus nerve trunks that control both electrical stimulation of the gastric ghrelin cells, and the parastolic muscular tone of the smooth muscles of the stomach to effect appetite and effect weight loss.10-09-2008
20110270220LINEARLY ACTUATED DISPENSER AND THERAPEUTIC PACKAGE SUITABLE FOR ADMINISTERING A THERAPEUTIC SUBSTANCE AND RELATED METHOD - A device for administering a therapeutic substance includes a sealed package and an administration assembly. The sealed package includes a collapsible compartment containing the substance. The administration assembly includes a dispenser that is in fluid communication with the substance. At least one compression member is movable by linear actuation to progressively collapse the collapsible compartment and urge the therapeutic substance through the dispenser.11-03-2011
20110270219ADMINISTRATION DEVICE HAVING A BUTTON WITH TOUCH SENSOR - Administration devices for supplying an injectable or infusible product into an organism include a reservoir for storing the product, a supply device for supplying the product from the reservoir into the organism, a controller to control operation of the administration device, a button communicatively coupled to the controller to initiate at least one action of the administration device and a touch sensor that generates an activation signal, wherein the touch sensor is incorporated into the button or is disposed in the vicinity of the button and is communicatively coupled to the button and/or the controller.11-03-2011
20080287909METHOD AND APPARATUS FOR INTRA-CHAMBER NEEDLE INJECTION TREATMENT - A method is disclosed that enables intra-chamber needle injection treatment using a navigable interventional device. The method includes navigation steps to systematically inject cells, drugs, or other agents in diagnostically identified target tissues, such as ischemic heart wall tissues. Magnetic navigation of a specifically designed needle catheter permits safe access to remote structures of the heart and depth-adaptable needle injections.11-20-2008
20100280488APPARATUS AND METHODS FOR DELIVERING FLUID AND MATERIAL TO A SUBJECT - The present invention provides fluid and material delivery methods and devices for practicing the methods. The invention provides a method of delivering cellular material comprising injecting the cellular material into a subject such that the injected cells retain their inherent morphologic characteristics upon injection. The method comprises the steps of aspirating the cellular material into a fluid delivery device which incorporates a syringe arrangement. The cellular material is aspirated into the main body of the syringe until the desired amount of a material has filled the syringe body. The needle of the fluid delivery device is then inserted into the skin of a subject at an angle about parallel to the skin until a desired depth has been reached. The cellular material is then injected in the subject until the desired volume of material has been injected. The needle of the device is then rotated approximately 45 to 90 degrees and the needle is removed from the injection site.11-04-2010
20100280487METHOD OF REMOVING A STYLETTE FROM A CATHETER - A hydrophilic coated stylette is pre-loaded in an implantable catheter. The hydrophilic coated stylette is wetted with saline to activate the hydrophilic coating. The stylette loaded catheter is tunneled, typically through muscle and tissue, to a desired target site within the body. The hydrophilic coated stylette is then removed from the catheter while maintaining the catheter intact. The proximal end of the catheter can be connected to an outlet of an implantable infusion pump so that medicament can be delivered directly to the target site.11-04-2010
20130218129Intradermal Delivery Device - A system and method is provided for an injectable substance delivery device comprising a limiter, shoulder or post that controls how deep the needle is inserted into the tissue. The limiter is sized in proportions that control the maximum insertion depth of the needle into the tissue without excessively restricting the complete insertion of the needle. The system and method further comprises an normalization or stabilizer ring that prevents distortion of the tissue in the vicinity of the infusion, so that the needle length is the major determining factor as to how deep the infusion is delivered.08-22-2013
20090264857LIQUID INFUSION APPARATUS - An apparatus and method are disclosed for controlling infusion of liquid into a patient using a peristaltic pump. The liquid infusion apparatus includes a liquid conduit having a proximal segment, a distal segment and an intermediate segment. The liquid infusion apparatus also includes a flow valve in fluid communication with the intermediate and distal segments. The flow valve includes a shuttle member slidably disposed within a housing about the distal segment, the shuttle member being configured for lateral movement relative to an elongated axis of the distal segment. The shuttle member is configured to operate in a first configuration to impede fluid flow through the liquid conduit and in a second configuration for which fluid flow through the liquid conduit is unimpeded. The shuttle member includes a resilient grasper for selectively engaging and disengaging a mating actuator resiliently received by the grasper.10-22-2009
20100298807APPLICATOR FOR INSERTING AN IMPLANT - The invention pertains to an applicator (11-25-2010
20080319414Insertion device - An insertion apparatus and a method for use with a device for delivery of a therapeutic fluid into a body of a patient and/or for sensing of a bodily analyte are disclosed. The apparatus includes a housing adapted for loading therein at least one cannula cartridge unit having a protective member. The protective member accommodates at least one penetrating cartridge having a subcutaneously insertable element and a penetrating member. The apparatus includes a displacement mechanism capable of protracting the penetrating cartridge towards the body of the patient, where protraction of the penetrating cartridge results in insertion of the subcutaneously insertable element into the body of the patient.12-25-2008
20080249503METHODS AND DEVICES FOR LUNG TREATMENT - A method of treating a lung comprises deploying a delivery catheter through a bronchial tree into a targeted lung region and delivering a fibrinogen suspension through the delivery catheter so that the fibrinogen suspension exits the distal end of the delivery catheter into the targeted lung region. Thrombin is also delivered through the delivery catheter so that the thrombin exits the distal end of the delivery catheter into the targeted lung region. The lung is promoted to collapse.10-09-2008
20110208157NEEDLE CONSTRUCTED WITH A TRANSPARENT OR TRANSLUCENT MATERIAL - In general, the invention features needles, with or without lumens, that contain a barrel being transparent or translucent or having a transparent or translucent portion. Needles of the invention may further include a lumen, the interior of which is visualizable through the transparent or translucent portion. A needle may also include a portion to which a suture is capable of being attached.08-25-2011
20100137833Methodology for drug delivery device with sliding valve - Drug delivery devices adapted to receive liquid medication vials to fill a reservoir, utilize sliding through valves that are closed except when driven by force of liquid medication pushed by a plunger to an open position to feed the medication via needle to a patient or via a connection to an IV port. The devices have multiple seals and automatically close up when pressure on the plunger is released. The methodology is also included.06-03-2010
20090054867Device for Administering of Medication in Fluid Form - An infusion device for continuously infusion of medication is disclosed, in which infusion is controlled over two separate fluid communications. The infusion is in each fluid communication controlled by restricting means and valve means, and one of the fluid communications further contains a holding device for bolus rate of infusion for a short period. The device comprises a flow regulating device comprising a passage defined by at least a fact element is a primary deformable element adapted to be elastically deformed so as to change the cross sectional area of the passage. Furthermore the device comprises a container for storage and supply of a medication in fluid form, said container comprising a first and a second chamber being arranged relatively to each other so that when volume of the first chamber increases the volume of the second chamber decreases.02-26-2009
20120197233Injection Arrangement - The invention relates to a pump unit (08-02-2012
20120197232METHODS AND DEVICES FOR AUTOFLUSH SYRINGES - Described herein are syringe devices, systems and methods. In general, the syringe may include a first chamber and a cartridge movable within the first chamber. The cartridge may include a cartridge chamber and a valve in fluid communication with the cartridge chamber and the first chamber and having an open configuration and a closed configuration. The valve may allow movement of a liquid out of the cartridge chamber while in a open configuration. The cartridge may also include a second end, movable within the cartridge chamber, and a locking mechanism having a locked configuration and an unlocked configuration, the locking mechanism preventing movement of the second end within the cartridge chamber while in the locked configuration.08-02-2012
20110208158Apparatus and Method for Endoscopic Submucosal Dissection - A kit and a method for delivering an injectable solution to a tissue treatment site are provided. The kit includes a housing having a chamber, a proximal portion and a distal portion. An injectable solution having a viscosity greater than about 10,000 cP is provided in the chamber. A plunger is provided in the proximal portion of the housing. The kit also includes a pressure gauge operably connected to the housing. The kit may also include a handle connected to the housing and a plunger advancing member having a plunger handle connected thereto provided separate from the housing. The kit may also include an inner shaft provided separate from the housing and having a proximal end portion configured for operably connecting with the distal portion of the housing for receiving the injectable solution therethrough and a distal end of the shaft configured for insertion in to the tissue treatment site.08-25-2011
20090082754Cannula implantation instrument - A cannula implantation instrument for use with the delivery of guide wire based implants includes a handle having an open slot for receiving a guide wire and a cavity for receiving an implant pre-mounted on the guide wire, a cannula having an open slot for also receiving a guide wire and a sharpened tip for introducing the cannula and guide wire simultaneously into the vas deferens of a patient, and a guide wire on which an intra vas implant is pre-mounted. The instrument further includes a safety clip on the handle that secures the guide wire and/or implant to the handle until released by a physician. The cannula implantation instrument may be ergonomically formed to provide comfort and ease while being handled by the physician.03-26-2009
20090177183CELL DELIVERY CATHETERS WITH DISTAL TIP HIGH FIDELITY SENSORS - The present invention relates to over the wire cell delivery catheters with high fidelity sensors at their distal end. These catheters are comprised of flow rate sensors and/or pressure transducer sensors. These catheters can also be comprised of occlusion balloons. The catheters of the present invention allow for administration of the highest and safest dose of therapeutic agents, e.g., adipose derived regenerative cells, on an individualized basis.07-09-2009
20090177182Glass Drug Chamber For Automated Ophthalmic Injection Device - A dispensing assembly has a glass tube assembly, a chamber housing, a needle, and a temperature control device. The glass tube assembly includes a glass tube with inner and outer surfaces and distal and proximal ends. A plunger is fluidly sealed to the inner surface of the glass tube at the proximal end, and a seal is located at the distal end of the glass tube. The chamber housing has an inner surface and an outer surface. The inner surface partially defines a chamber for receiving the glass tube assembly. The needle has sharp distal and proximal ends, traverses the chamber housing, and is fluidly coupled to the chamber. The temperature control device at least partially surrounds the chamber housing. The proximal end of the needle is arranged to puncture the seal when the glass tube assembly is pressed against the proximal end of the needle.07-09-2009
20090177184METHOD AND APPARATUS FOR IMPROVING VENOUS ACCESS - Embodiments of the invention include a method and a device for increasing vasodilatation and/or controlling the temperature of a mammal by applying a desired vacuum pressure to the skin of the extremity of a mammal. In some cases it is also desirable to provide heat to regions of the extremity of the mammal to further dilate the veins or arteries in the patient. In some cases it is also desirable to apply a contact pressure to regions of the extremity of the mammal to improve perfusion of these regions. In one embodiment, the device includes a device that is adapted to rigidly enclose a portion of an extremity of the mammal therein so that a sub-atmospheric pressure can be applied to the mammal's extremity, which is further discussed below.07-09-2009
20090187160METHODS AND DEVICES FOR DELIVERING AGENTS ACROSS BIOLOGICAL BARRIERS - The invention provides for microneedle devices for delivering agents across biological barriers. The microneedles include agent reservoirs integrated into the bodies of the microneedles, themselves.07-23-2009
20090198215ADHESIVE PATCH SYSTEMS AND METHODS - Various embodiments of the present invention are directed to patches for medical devices. In various embodiments, an adhesive patch of a medical device may have selective areas with adhesive material of varying adhesion strengths. In other embodiments, an adhesive patch of a medical device may include adhesive material that may be activated by a catalyst to increase or decrease the adhesion strength of the adhesive material. In further embodiments, a medical device may include a pierceable membrane containing an agent, the pierceable membrane positioned to be pierced by a needle and to cause some of the agent to be carried to the user-patient.08-06-2009
20090198211Convenience IV kits and methods of use - A convenience kit which provides a basic configuration for use in measuring, filling and dispensing medication and flush solutions to IV sets and patient catheters through needleless connectors while improving safety and efficacy by requiring fewer post-sterilization makes and breaks compared to conventional filling and dispensing methods. Further, the kit improves flush compliance by facilitating dispensing of flush solutions and decreases likelihood of infections by providing for flushing of patient lines and catheter connecting fittings without line breaks. Convenience of operation is provided by a two-syringe assembly which is operable by a single hand for selective dispensing accomplished from either of the two syringes while obstructing flow from the other syringe. The kit comprises a clip for stabilizing the two syringe assembly.08-06-2009
20090198213METHOD OF OPHTHALMIC SURGERY AND KIT THEREFOR - A method of micro-incision ophthalmic surgery, comprising, in the order mentioned, the steps of:08-06-2009
20090054866Transcutaneous Device Assembly - A medical device is provided comprising a cannula having a distal portion adapted to be arranged through the skin of the subject, and an outer needle arranged coaxially with and being axially moveable relative to the cannula, the needle comprising a pointed distal end, wherein the device is adapted for advancing the cannula with the distal end of the needle projecting there from through the dermis of the subject, and subsequently retract the needle.02-26-2009
20090192492SINUS DELIVERY OF SUSTAINED RELEASE THERAPEUTICS - The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.07-30-2009
20090192491SINUS DELIVERY OF SUSTAINED RELEASE THERAPEUTICS - The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.07-30-2009
20090192490SINUS DELIVERY OF SUSTAINED RELEASE THERAPEUTICS - The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.07-30-2009
20090192486AUTOMATIC INJECTOR WITH ANTI-CORING NEEDLE - In one embodiment, an automatic injector comprises a cartridge adapted to contain a charge of medicament, a seal structure disposed toward a forward end of the cartridge, a plunger normally disposed in a generally rearward end of the cartridge and movable through the cartridge toward a generally forward end thereof in response to an actuating procedure. The movable plunger rearwardly confines the medicament within the cartridge. A needle normally disposed in communication with the medicament container provides a passage in which the medicament is released into an individual's flesh in response to an actuating procedure projecting the needle into the flesh of the individual. The cartridge having an increased friction region so as to slow the motion of the plunger when the forward end of the needle travels through the seal in order to eliminate coring.07-30-2009
20120078226INJECTION CATHETER FOR DELIVERING A THERAPEUTIC AGENT INTO A SUBSTRATE - The invention relates to an injection catheter for delivering a therapeutic agent into a substrate, comprising one or more lumens and a curved delivery element, said lumen serving as a guide for said curved delivery element outside of the substrate; said curved delivery element comprising openings on its distal tip, said distal tip comprising a distal zone and a proximal zone, said injection catheter being characterized in that the specific surface in said distal zone of said distal tip of said curved delivery element is higher than the specific surface in said proximal zone of said distal tip of said curved delivery element. The invention also relates to a process for delivering a therapeutic agent into a substrate.03-29-2012
20120078225Dual Chamber Syringe With Retractable Needle - Embodiments of a retractable syringe assembly are provided that include a dual syringe barrel configuration. One or more embodiments include reuse prevention features and features that prevent premature activation of the retraction mechanism. Methods for aspirating and expelling liquid from medical devices are also provided.03-29-2012
20120078224DEVICE AND METHOD FOR INTRAOCULAR DRUG DELIVERY - Devices for delivering pharmaceutical formulations into the eye are described. The devices may be integrated to include features that allow safe and atraumatic manipulation of the devices with one hand. For example, accurate placement, including proper angulation, of the device on the eye and injection of a pharmaceutical formulation into the eye can be performed using one hand. The devices may also include improved safety features. For example, the devices may include an actuation mechanism that controls the rate and depth of injection into the eye. Some devices include a dynamic resistance component capable of adjusting the amount of pressure applied to the eye surface. Related methods and systems comprising the devices are also described.03-29-2012
20120078223WARMING GARMENT AND METHOD FOR PROMOTING VASODILATION - A warming garment and method of making and using are provided. The warming garment may have an inner lining and an outer lining which may form an annular space in which an exothermic composition that is activated upon exposure to oxygen may be disposed. When worn, the warming garment may aid in inducing vasodilation upon a subject's limb through the emanation of heat from the exothermic composition. Once vasodilation is achieved, venipuncture or catheter insertion procedures may be properly initiated.03-29-2012
20120078222INFUSION PUMPS - Ambulatory infusion pumps, pump assemblies, cartridges, baseplates, cannulas, insertion tools, and related components as well as combinations thereof and related methods.03-29-2012
20110224647BODY CAVITY DRAINAGE DEVICES AND RELATED METHODS - Body cavity drainage devices and associated methods are disclosed herein. In some embodiments a body cavity drainage device comprises a drainage tube having a proximal end and a distal end; and an automated means to move the distal end of the drainage tube about a body cavity of a patient. In some embodiments, the distal end of the drainage tube may be moved by one or more of the application of a magnetic field, the insertion or withdrawal of fluid from a closed lumen, and manipulation by an external motion generator. In additional embodiments, a body cavity drainage device includes at least a second open lumen for the insertion of a fluid into a body cavity. In yet further embodiments, an internal tissue may be massaged from within a body cavity of a patient.09-15-2011
20110144619MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS - Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. A valve for maintaining a constant flow rate through the cannula independent of the pressure applied to the device may be included.06-16-2011
20090209939RECONSTITUTION MEANS FOR SAFETY DEVICE - The present disclosure describes a needle guard device or system that can be used with drugs requiring reconstitution. The needle guard is preferably a passive needle guard that can be used during reconstitution without activating the safety mechanism. Following administration of the medication, the needle guard shields a user from inadvertent needle sticks by extending a protective shield over the needle.08-20-2009
20090247984USE OF MICRONEEDLES FOR SMALL MOLECULE METABOLITE REPORTER DELIVERY - Systems that can include a microneedle array and a small molecule metabolic reporter are disclosed. The systems can be used to penetrate the epidermis and monitor the change in concentration of one or more metabolite or analyte.10-01-2009
20090204102INTRADERMAL SYRINGE AND NEEDLE ASSEMBLY - A method for using a needle assembly for an intradermal injection, and a drug delivery device is provided, which includes a needle cannula and a limiter surrounding the needle cannula and includes a skin engaging surface on the limiter. The limiter is moveable from a first position in which an elongate portion of the needle cannula is exposed for access to a medication vial, to a locked second position in which the limiter is not movable from the second position to the first position. In the second position, the needle tip extends beyond the skin engaging surface a distance of about 3 mm or less.08-13-2009
20090240232MULTI-CARTRIDGE FLUID DELIVERY DEVICE - A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments.09-24-2009
20090192489SINUS DELIVERY OF SUSTAINED RELEASE THERAPEUTICS - The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.07-30-2009
20090192487System and Method for Intracranial Implantation of Therapeutic or Diagnostic Agents - A system and related method for delivering the anti-tumoral agent carmustine or other types of diagnostic or therapeutic agents into the brain of a patient with a brain tumor includes an insertion device, a skull mount, and a reformulated geometry of the carmustine compound (or other material) optimized for use in the insertion device and for maximized biodegradation time. The insertion device may be front loaded with the carmustine material (or other material) and inserted through the mount on a skull, to the location of the brain tumor, where the carmustine (or other material) is then released. It should be appreciated that the diagnostic and/or therapeutic system and related method thereof are not necessarily limited to the brain of a subject. It may also be used in the organ structures or tubular structures, as well as portions and locations thereof.07-30-2009
20090254061METHOD AND APPARATUS FOR REMOVING CEREBROSPINAL FLUID - An apparatus for removing cerebrospinal fluid includes a first needle having a first end, a second end, and a passage extending between the first and second ends. The proximal end of the first needle has a handle and the distal end has a cutting tip adapted to penetrate skin. A second needle is slidably disposed within the passage of the first needle. The second needle has a proximal end, a distal end, and a lumen extending between the proximal and distal ends. The proximal end of the second needle has a handle. The distal end of the second needle has an atraumatic tip and a microfilter in fluid communication with the lumen for removing cerebrospinal fluid.10-08-2009
20090254060Motor assembly for injection control device - A spring motor mechanism for use in an injection control device having a metered/controlled injection rate proportional to the rate of withdrawal/injection suitable for cosmetic as well as other applications is described. After the cannula is advanced into an object (person) the cannula is withdrawn to create a tract or tunnel within the targeted area. As the cannula is withdrawn, filler material in the injection control device is uniformly deposited into the tract or tunnel via the automatic metering system. As one feature, the spring motor mechanism automatically retracts the positioning guide that is used in the metering systtem. The spring motor mechanism may be replaceable or customizable, offering the user enhanced safety and convenience of operation for the injection control device.10-08-2009
20100152700INTEGRATED STORAGE AND DELIVERY SYSTEMS FOR NUTRITIONAL COMPOSITIONS - Apparatuses, kits and methods useful in the storage and delivery of nutritional compositions and other fluids are described. In a general embodiment, an integrated storage and delivery system for nutritional compositions comprises a container defining a chamber, a finish, and a penetrable seal. The finish defines an opening and the penetrable seal separating the chamber from an external environment. A spike assembly is attached to the container. The spike assembly including a cap and a spike. The cap is engaged with the finish of the container and the spike defines a projection having a distal end defining a second opening. The projection is moveable between a first position in which the distal end is adjacent a first side of the penetrable seal and a second position in which the distal end is adjacent a second side of the penetrable seal.06-17-2010
20100152701METHODS AND DEVICES FOR DELIVERING AGENTS ACROSS BIOLOGICAL BARRIERS - The invention provides for microneedle devices for delivering agents across biological barriers. The microneedles include agent reservoirs integrated into the bodies of the microneedles, themselves.06-17-2010
20100179508PACKING FOR AN INFUSION SET AND METHOD OF APPLYING AN INFUSION SET - The present invention relates to a packing for an infusion set. An infusion set for intermittent or continuous administration of a therapeutical substance, such as insulin, comprises an infusion part having a cannula penetrating the skin of a patient and a connector which connects the infusion part with a medical device such as an adaptor for a syringe or an insulin pump. The insertion of the infusion part will be performed with an insertion needle which is delivered together with the infusion part under sterile conditions. The packaging comprises an impenetrable part (07-15-2010
20100174267HOLLOW CURVED SUPERELASTIC MEDICAL NEEDLE AND METHOD - A needle assembly 07-08-2010
20110238037GAS-PRESSURED MEDICATION DELIVERY DEVICE - The present invention relates to medical devices and particularly to a medication delivery device for self-injection of a medication, or for healthcare professionals to administer a medication. In one embodiment, a medication delivery device utilizes a source of gas pressure to deploy a needle, deliver a desired amount of medication through the needle, and retract the needle for disposal. Fluid flow paths from the source of gas pressure communicate the gas pressure to the needle and to the medication in order to accomplish these steps. In one embodiment, a valve is positioned to open and close the flow of the pressurized gas to the needle and the flow of the medication to the needle, so that the valve can be operated to deploy the needle and deliver the medication through the needle when the user is ready for the injection. The valve can also be operated to retract the needle when the dose is complete.09-29-2011
20100160894Automatic injection device - The invention provides an automatic injection device for providing a subcutaneous injection of a substance into a user, comprising: a housing having an open first end and a second end; a syringe movably disposed in the housing, the syringe including a barrel portion for holding the substance, a hollow needle in fluid communication with the barrel portion for ejecting the substance from the syringe, and a bung for sealing the barrel portion and selectively applying pressure to the substance to force the substance through the hollow needle; a plunger for first moving the syringe towards the first end such that the needle projects from the first end and subsequently applying pressure to the bung, the plunger including a rod connected at a first end to the bung, a compressible expanded central portion and a flange between a second end of the rod and the compressible expanded central portion; and a biasing mechanism for biasing the plunger towards the first open end of the housing, the biasing mechanism disposed about the second end of the rod between the flange and the second end of the housing. The present invention also provides methods and kits for using an automatic injection device, and methods and kits for promoting an automatic injection device comprising a medication based on advantageous properties of the device as compared to a pre-filled syringe. The invention also provides methods and kits for training a recipient on use of the automatic injection device.06-24-2010
20100241102INTRAVITREAL INJECTION DEVICES AND METHODS OF INJECTING A SUBSTANCE INTO THE VITREOUS CHAMBER OF THE EYE - Intravitreal injection devices include an injection assembly adapted to receive an injector, and an alignment guide adapted to facilitate placement of the injector relative to a patient's eye for injecting an injectant therein. The injection assembly, in response to a user input, is adapted to automatically and sequentially first, translate the injector into the patient's eye, and then second, dispense the injectant from the injector. In some embodiments the injector is a typical syringe. Some embodiments are adapted to receive syringes having different configurations. Methods of injecting an injectant into a patient's eye are also provided.09-23-2010
20100217231Device for administering an at least two-component substance - The device for administering an at least two-component substance comprises a concentric lumen arrangement including (i) an inner cannula having a lumen with an inlet opening at a first end and a tip with an outlet opening at a second end opposite its first end, and (ii) an outer sheath having opposite first and second ends facing the respective first and second ends of the inner cannula, and surrounding the inner cannula along an axial length between the first and second ends of the inner cannula, wherein the outer sheath at its second end is sealingly and fixedly connected to the inner cannula and defining an outer lumen around the inner cannula, and wherein the inner cannula is provided with at least one opening for providing fluid communication between the outer lumen around the inner cannula and the lumen of the inner cannula.08-26-2010
20100228226Inserter Having Two Springs - The invention relates to an inserter for a medical device e.g. an infusion set or the like for intermittent or continuous administration of a therapeutical substance, such as e.g. insulin. The inserter comprises a needle hub comprising an insertion needle and two elastic elements assuring automatic insertion and automatic retraction of the insertion needle. Activation of the first elastic element (09-09-2010
20100228225METHOD AND SYSTEM FOR DELIVERY OF NEUROTOXINS - A method and system for delivering a neurotoxin into the body of a subject is disclosed. The method includes sequentially applying one or more arrays of micro needles on a portion of the skin of the subject that requires treatment. The micro needles are pre-coated with the neurotoxin on an array comprised of 10 to 1,000 micro needles over an area of 1 mm09-09-2010
20100228227DUAL ACCESS SINUS SURGERY METHODS AND SYSTEMS - A method for sinus surgery includes piercing first and second access openings into the anatomy of a human subject to access an inaccessible sinus site for cooperatively manipulating respective first and second surgical instruments inserted through the openings. One instrument, for example an endoscope, can permit viewing of the sinus site while the other instrument is manipulated to effect a treatment at the sinus site. The maxillary and other sinuses can be accessed and anti-inflammatory and other treatments can be applied. Systems and instruments for performing such sinus surgery methods are also disclosed.09-09-2010
20130123749DRUG DELIVERY PUMP DRIVE USING LINEAR PIEZOELECTRIC MOTOR - A drug delivery pump drive which uses a linear piezoelectric motor to advance a syringe piston to deliver a liquid drug and a method thereof are disclosed. The pump drive, provided in a drug delivery pump, provides silent operation and very low energy consumption compared to electric motor-based drives. The small size of the motor helps also to reduce overall size of the pump drive and the resulting drug delivery pump.05-16-2013
20120130342AUTOINJECTOR HAVING AN OUTER PACKAGING AND A NEEDLE SHEATH REMOVING MEANS - An autoinjector device for delivering a dose of medicament including a syringe including a needle wherein, prior to use of the device, the needle is substantially covered by a needle sheath (05-24-2012
20100241103CARTRIDGE ADAPTER FOR USE IN AN INFUSION SYSTEM - Infusion systems for pumping fluid into a body of a user, and methods for providing infusion systems, are disclosed. The infusion systems include an infusion pump, wherein the infusion pump comprises an infusion pump housing including a cavity. A fluid storage is removably inserted into the cavity of the infusion pump housing wherein, the fluid storage comprises a cartridge and an adapter connected to the cartridge such that the adapter encases the cartridge, and an infusion set is removably connected to the fluid storage.09-23-2010
20100222768METHODS FOR CAPACITANCE VOLUME CORRECTION IN FLUID DELIVERY SYSTEMS - A method of capacitance volume correction in fluid-containing expandable bodies and associated fluid pathways is disclosed for application in fluid delivery systems used to supply fluids to patients during radiographic imaging procedures including angiography. One embodiment is directed to a method of controlling delivery of fluid to a downstream process, including providing a fluid-containing expandable body, including a pressurizing element and in fluid communication with the downstream process, pressurizing the expandable body by moving the pressurizing element forward in the expandable body to reduce volume therein, and ceasing movement of the pressurizing element after allowing the pressurizing element to over-travel a sufficient distance to compensate for expansion of the expandable body under pressure. The expandable body may be a syringe and the pressurizing element may be a plunger disposed within the syringe. Movement of the pressurizing element is controlled by an algorithm associated with a computer.09-02-2010
20100222767Markers for needles including temporary and pen injector types - A Marker on the dorsal (top) side of a needle allows a visually challenged user to maintain an orientation of the needle from a point within the user's comfortable visual focusing range to a desired injection site09-02-2010
20120130340Tissue Desensitization Instrument & Method - An automatic fluid injector (05-24-2012
20130218127Anchoring An Intravenous Cannula - Some embodiments of a medical system include a subcutaneous anchor device that extends outwardly from side wall of an intravenous cannula so as to secure the intravenous cannula in a position relative to a skin penetration point.08-22-2013
20130218128AUTOINJECTORS - An autoinjector includes a housing for receiving in use in a generally longitudinal loading direction a syringe assembly including a syringe carrier and a syringe, the syringe including a syringe body having a slideable internal piston for expressing a dose contained in the body through a needle at a forward end thereof; a drive mechanism for providing drive for operation of the autoinjector and being disposed generally within the housing and including a mechanical energy source and a winder element for being rotated to charge the energy source, and an input transmission train operational between the syringe assembly and the winder element in use, whereby loading of the syringe assembly into the housing rotates the winder element to charge the energy source.08-22-2013
20130218130Dose Setting Mechanism or Priming a Drug Delivery Device - A method and system for priming a drug delivery device. The drug delivery device includes a dose dial sleeve and an internal housing portion. The dose dial sleeve is coupled to the internal housing. The dose dial sleeve rotates on a substantially circumferential rotational path during priming of the drug delivery device. Further, the dose dial sleeve rotates on a helical path during dose setting of the drug delivery device.08-22-2013
20100211043METHODS FOR FIXING A GASTROINTESTINAL DEVICE IN THE GI TRACT - A method for fixing a gastrointestinal (GI) device in a GI tract, the method including introducing a substance into a tissue of the GI tract that reduces or eliminates the tissue's physiological capability to reject foreign bodies, and fixing a GI device into the tissue where the substance has been introduced.08-19-2010
20100211042Drug Delivery Device - Embodiments of the invention generally provide a device and method for minimizing injection pain and preventing needle clogging during injection of a drug formulation into skin. Generally, the invention provides a device comprising a needle having a point to penetrate skin on one end, a hub having a diameter larger than that of the needle attached to the opposite end of the needle and connectable to a housing defining a chamber for receiving a formulation, and a polymer wrap attached to the hub, wherein the polymer wrap is tapered to the needle so as to pass through skin when the point is inserted into the skin, and wherein a space between the needle and the polymer wrap lies in a flow path of the formulation into the skin, such that formulation is injected through the space between the needle and the polymer wrap.08-19-2010
20100137832Auto-Injector Apparatus - An auto-injector apparatus includes a flexible container containing a liquid medicant, a needle communicated with a container, a housing with a container being received in the housing, a pump disposed in the housing and positioned to engage the flexible container and expel the medicant from the container through the needle upon relative movement between the pump and the container, and a main drive spring operably associated with the needle to extend the needle from a first needle position wherein the needle is completely received in the housing to a second needle position wherein the needle protrudes from the housing. The pump may be a roller.06-03-2010
20110238038INTRADERMAL MINI - NEEDLE INTERFACE AND ASSOCIATED DEVICES AND METHODS - An intradermal mini-needle interface has a penetration limiter providing a skin contact edge and a hollow hypodermic needle having a beveled penetrating portion protruding forward beyond the skin contact edge by no more than 3 mm. At least one skin contact surface defines a skin contact plane parallel to, or at a shallow angle to, the needle axis. The skin contact plane intersects the skin contact edge substantially at a base of the penetrating portion. Preferably, the penetration limiter is asymmetric under rotation about the needle axis.09-29-2011
20100198189SPINAL MULTISEGMENTAL CELL AND DRUG DELIVERY SYSTEM - Delivery devices and methods related thereto may be used in humans for spinal delivery of cells, drugs or vectors. The patient population may include patients with spinal traumatic injury, amyotrophic lateral sclerosis, multiple sclerosis, spinal ischemia and any other spinal neurodegenerative disorders which will require spinal cell, vector or drug delivery. Unlike conventional methods which require multiple injection sites to make multiple, localized substrate deliveries, the delivery devices and methods of the present invention may allow for multiple substrate delivery locations with homogeneous substrate delivery with a single injection site.08-05-2010
20110130743Re-Useable Auto-Injector with Filling Means - An injection device having a first sub-assembly comprises a housing and a chamber. The chamber is disposed within the housing and has proximal and distal ends, an inner surface and an exit aperture. The sub-assembly comprises a stopper movably disposed within the chamber. The stopper has an outer surface substantially in contact with the inner surface about its perimeter. The sub-assembly comprises a port adapted to receive a container containing a fluid. The stopper is fixed with respect to the housing and movement of the port causes movement of the exit aperture in relation to the stopper.06-02-2011
20090318888Prefillable Intradermal Delivery Device - An intradermal delivery method for use in intradermally injecting substances into the skin of an animal includes a needle cannula supported by a hub portion that is attachable to a prefillable container. A limiter portion surrounds the needle cannula and extends away from the hub portion toward a forward tip of the needle cannula. The limiter portion includes a skin engaging surface extending in a plane generally perpendicular to an axis of the needle cannula. The skin engaging surface is received against skin of an animal to administer an intradermal injection. The forward tip extends beyond the skin engaging surface a distance that enables penetration of the needle cannula into the dermis layer of the skin of the animal enabling injection of the substance into the dermis layer of the animal. The device includes enclosure means that is moveable for concealing the needle cannula after the injection has been administered.12-24-2009
20090112181Device and method for delivering or withdrawing a substance through the skin - An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid.04-30-2009
20110071493Flow-Induced Delivery from a Drug Mass - Drug solutions (or other combinations of vehicle with entrained drug) are prepared by removing drug from one or more masses of a solid form of the drug. The solid form of the drug may be sparingly soluble or insoluble in water. Examples of devices for holding solid drug and facilitating delivery of such drug to targeted regions are also described.03-24-2011
20110112507CURABLE MATERIAL DELIVERY SYSTEMS AND METHODS - A distal end of a cannula immediately proximate a target site within bone. A portion of a cavity-forming device is extended through the cannula and distally beyond the distal end, and then operated to form a cavity at the target site. A track is defined in tissue of the target site between the distal end of the cannula and the cavity. The cavity-forming device is removed from the cannula, and replaced with a delivery tube. A distal tip of the delivery tube is directed distally beyond the distal end of the cannula, through the track and into the cavity. Finally, a material (e.g., a curable material) is delivered through the delivery tube and into the cavity. The cannula can remain stationary following initial insertion, and curable material is not directly deposited into the normally occurring “dead space”.05-12-2011
20090069788System And Method For Delivering Fluid Into Flexible Biological Barrier - A system and method for delivering fluid into a flexible biological barrier employs a microneedle structure wherein a final position of microneedles (03-12-2009
20130138078INFUSION PUMPS AND INSERTERS FOR USE WITH SAME - Ambulatory infusion pumps, pump assemblies, and disposable assemblies, including cartridges, baseplates, cannulas, inserters, and related components therefor, as well as component combinations and related methods.05-30-2013
20130138079SYRINGE AND METHOD FOR RECONSTITUTION OF DRY-FORM DRUGS AND MEDICINES - A method of reconstituting and administering an injectable fluid distributed to practitioners in dry-form includes receiving a drug or medicine in dry form, selecting a reconstitution concentration for the drug or medicine, reconstituting a desired number of units of the drug or medicine by adding diluent to the dry-form drug or medicine, selecting a syringe having units marked according to the selected reconstitution concentration, drawing up a desired number of drug or medicine units using the selected syringe, and administering a desired number of units according to the unit markings on the selected syringe. Such a syringe includes a barrel, a plunger assembly that has a plunger handle and a piston, a needle, and a needle cap. The syringe includes a visual indicia, representing a first drug concentration contained in the barrel, that is distinguishable from a corresponding visual indicia, on a second syringe, representing a second drug concentration.05-30-2013
20090036868Spring Driven Ophthalmic Injection Device with Safety Actuator Lockout Feature - An ophthalmic injection device includes a dispensing chamber housing with an inner surface that partially defines a dispensing chamber for holding a substance, a plunger fluidly sealed to the interior surface of the dispensing chamber housing, and a needle fluidly coupled to the dispensing chamber. A temperature control device partially surrounds the dispensing chamber housing and alters a temperature of the substance. A piston is coupled to the plunger at one end and to a spring at the other end. The spring provides a force to drive the piston and the plunger. An actuator is coupled to the lockout bar with which a button is configured to interface. The actuator moves the lockout bar when the substance reaches a temperature, thereby allowing the button to be activated so that the spring provides the force to drive the plunger. An incorporated stop whose measurements may vary allow the expelled dosage to vary accordingly.02-05-2009
20130144262Package for Delivering Microdoses of Medicament - A primary package for simultaneously dispensing microdoses of from 5 to 500 microliters of one medicament contained in a medicated module and another medicament contained in an attached injection system is disclosed, where the primary package contains a single dose of medicament contained within a reservoir cavity sealed with closure caps that secure top and bottom septa.06-06-2013
20100331814Systems And Methods For Atraumatic Implantation Of Bio-Active Agents - Methods and apparatus are provided for delivering a bioactive agent in a needle track formed in a target tissue mass, following formation of the needle track, by avoiding impingement of the agent against target tissue at high velocity or by using capillary action to draw the bioactive agent out of the needle during needle withdrawal. The apparatus comprises a catheter and a needle disposed within the catheter and configured to be selectively extended into the tissue mass to a predetermined depth, while dispensing the agent simultaneously with retraction of the needle along the needle track. Alternatively, or in addition, the needle may be configured to create a tissue space surrounding a distal or lateral surface of the needle, into which the bioactive agent to be infused.12-30-2010
20100262123Pre-Filled Syringe Having Flexible Hinge - A method of using a syringe and a flexible member is described. In some versions, the method may involve providing a syringe, a needle, a pre-filled cartridge, an adapter, a flexible member, a biasing element, and a guard. The method may involve retaining the guard, releasing the guard by actuating the flexible member to translate the guard in the distal direction to cover the needle, and locking the guard. In some versions, the flexible member may have a first and second position for actuation. In some versions, the flexible member may engage and disengage the guard to retain and release the guard.10-14-2010
20100262122Pre-Filled Syringe Having Internal Guard - A method involving a syringe, a plunger, a needle, and a guard is described. The method may comprise the guard moving and/or translating within the syringe. In some versions, the plunger may be inserted into a syringe body of the syringe. The plunger may be moved within the syringe body. In some versions, the guard may have a retracted position, and the guard may travel axially within the syringe body. In some versions, the guard may translate within the syringe body such that it touches the skin of the patient. In some versions, the guard may cover the needle by axial translation within the syringe body.10-14-2010
20100262121Pre-Filled Cartridge Plunger Method - A method involving a syringe, a pre-filled cartridge, a needle, a guard, and a release mechanism is described. The method may involve inserting the cartridge into the syringe. In some versions, the method may involve releasing the guard to cover a portion of the needle. In some versions, the method may involve the release retaining the guard in a retracted position. In some versions, the release may be operable to be actuated to release the guard. In some versions, the guard may be extended and locked once extended to cover the needle.10-14-2010
20110009847SYSTEMS AND METHODS FOR CREATING AND USING SUCTION BLISTERS OR OTHER POOLED REGIONS OF FLUID WITHIN THE SKIN - The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.01-13-2011
20110040280INJECTOR - An injector includes a support tube having one end surface to be brought into contact with skin, a movable tube advanceable in the support tube in the direction of the skin, an injection needle communicating with the movable tube, a plunger advanceable in the movable tube in the direction of the skin to introduce medicinal liquid filled in the movable tube to the injection needle, and a sealing material provided at the tip of the support tube and penetratable by the injection needle to penetrate the sealing material. In an initial state, the tip of the injection needle is sealed by the sealing material.02-17-2011
20110040279Particle Delivery - A method for delivering particles to a target location of a subject includes slidably disposing a polymeric carrier in a lumen of a catheter. The lumen extends in the catheter from a proximal opening to a delivery region. The method further includes inserting the delivery region of the catheter in the target location of the subject and forcing the particles through the lumen of the catheter to cause the carrier and the particles to exit the delivery region of the catheter. The particles may be cells or drug-loaded microspheres. The carrier can serve to retain the particles in the target location for a period of time. For treatment of vertebral disc degeneration, the particles can be stem cells, the carrier can be formed from collagen, and the target location can be the nucleus pulposus.02-17-2011
20110245801IMMOBILIZING OBJECTS IN THE BODY - Stabilizing an object in the body of a patient involves the injection of a lower critical solution temperature (LCST) material or other flowable material into the body of the patient so that the material contacts the object. The LCST material or other flowable material then forms a gel in the body such that the object is contained at least partially within the gel and thereby stabilized by the gel such that the object can then be easily fragmented within the body and/or retrieved from the body.10-06-2011
20090062768Systems and methods for delivering medication - Systems and methods for delivering medication to a patient are disclosed. The system has a reservoir, a sequencer/monitor, and an insertion set which are mated during use.03-05-2009
20110245800DEVICES, SYSTEMS, AND METHODS FOR TRANSEPTAL ATRIAL PUNCTURE USING AN ENGAGEMENT CATHETER PLATFORM - Multichannel systems for engaging a bodily tissue and methods of using the same. In at least one embodiment of an exemplary multichannel system for engaging a tissue of the present disclosure, the system comprises an engagement catheter comprising a proximal end, a distal end, and defining a first lumen and second lumen extending between the proximal end and the distal end, an inducer sheath having a proximal portion and a distal portion, and defining a lumen extending therethrough, the inducer sheath configured for insertion into the second lumen of the engagement catheter, and a dilator defining a first channel and a second channel extending therethrough and a tapered tip at the distal end of the dilator, the dilator sized and shaped for inserted into the lumen of the inducer sheath.10-06-2011
20110245799SYSTEM AND METHOD FOR DELIVERY OF SUSPENSIONS AND OTHER MICROPARTICLE COMPOSITIONS - Disclosed herein are systems and methods useful for delivery of suspensions and other microparticle compositions, and, in particular, for delivering microparticles at desired dosing levels and eliminating blockages within microparticle suspensions positioned within a delivery device.10-06-2011
20110213333Hollow Curved Superelastic Medical Needle And Method - A needle assembly 09-01-2011
20110213335HOLLOW MICRONEEDLE ARRAY AND METHOD - Rapid, high-volume, intradermal infusion with minimal pain, is achived by applying an array of 10 to 30 hollow microneedles having a length of greater than 100 um to less than 1 mm into the skin of a patient, with a microneedle spacing of no less than 1.5 mm on average between adjacent microneedles, and pumping greater than 200 uL of fluid through the hollow microneedles at a rate of greater than 20 uL/min.09-01-2011
20110087189CONTROLLED DELIVERY OF SUBSTANCES SYSTEM AND METHOD - A fluid infusion system is described. Certain embodiments include an infusion syringe assessment device that assesses one or more characteristics of an infusion syringe coupled to a fluid infusion pump during use. The system may include a fluid infusion pump configured to accept the infusion syringe. The fluid infusion pump may advance an infusion fluid to a test subject in accordance with an infusion routine based on one or more of the assessed characteristics of the infusion syringe. The infusion routine may include at least one rate, at least one volume, at least one start time, at least one end time, and/or at least one duration.04-14-2011
20100022988INFUSION SET WITH A DATA STORAGE DEVICE - An infusion device, an infusion set and a system and method involving one or the other and/or both, wherein the infusion device interacts with the infusion set, and/or wherein the device, set, system and method ensure that deviations from the therapeutically suitable operating state of an infusion set attached to the infusion device can be detected and rectified in an automated manner or with the assistance of the person using the infusion device.01-28-2010
20090048575TROCAR WITH OBTURATOR HAVING LONGITUDINAL THROUGH HOLES FOR GUIDING WIRES - Surgical apparatus includes a trocar and obturator. The trocar has a hollow cylindrical body with a handle at the proximal end thereof. The obturator has a solid cylindrical body with a handle at the proximal end thereof. A central through hole is provided extending through the body and a slot is provided in the circumference of the body, extending parallel to the hole. Guide wires can selectively extend through either the central hole or along the slot.02-19-2009
20090312744Pulsatile flux drug delivery - A method of delivering a therapeutic fluid to the tissue of a mammal using pulsatile flux to prevent fluid backflow.12-17-2009
20120245559Grip for self-injectable device - The present invention, in one embodiment, is a gripping apparatus to ergonomically grip a self-injectable device (such as, for example, an insulin pen) to thereby provide a user's fingers with a gripping means on the self-injectable device so that the combination of the apparatus with the self-injectable device facilitates one-handed operation on various parts of the human body and comprises a complete operational self-injectable assembly. The apparatus is adapted to snap-fit the body of a self-injectable device (e.g., an insulin pen) by inserting the self-injectable device longitudinally through the flange apertures of the apparatus, and twisting the apparatus around the device's body until the apparatus is in snug engagement with the device. The apparatus assists the user in using the self-injecting device for injection on any portion of the human body.09-27-2012
20120245558SELF-INJECTION DEVICE - A self-injection device (09-27-2012
20100057045Apparatus, system and method for manipulating a surgical catheter and working device with a single hand - Systems and methods are disclosed that include a guide catheter apparatus insertable through a external body passage of a subject. The guide catheter apparatus includes a substantially rigid shaft and a handle. The shaft has a proximal opening, a distal opening, and a lumen extending between the proximal opening and the distal opening. The handle has a structure to allow a position of the guide catheter to be controlled by some or all of three fingers of one hand of an operator of the handle. The structure of the handle is adapted to permit the operator to position a thumb and index finger of the hand to manipulate a working device inserted into the lumen of the guide catheter, where the working device is manipulable via a portion of the working device immediately adjacent to the handle.03-04-2010
20120245557Laminar Injection Apparatus and Method - A laminar injection apparatus may include a slider layer, a needle flexibly coupled to the slider layer, a medication reservoir in fluid communication with the needle, and a needle guiding layer comprising an aperture for deflecting the needle from a substantially horizontal orientation to a substantially vertical orientation in response to moving the slider layer relative to the needle guiding layer. One or more spring layers may extend the laminar structure into an extended laminar structure. The needle may be thrust into a subject by compressing the extended laminar structure and causing the needle to protrude from the structure and penetrate a subject. In response to the compressive force on the laminar stack, medication may be forced from the medication reservoir through the needle and into the subject.09-27-2012
20090216216METHODS OF PERFORMING A POWER INJECTION PROCEDURE - Methods of performing a power injection procedure are described. One method includes taking an x-ray of a subcutaneously implanted access port in a patient to determine whether the access port includes a radiographic feature indicating that the access port is suitable for flowing fluid at a rate of at least about 1 milliliter per second through the access port, identifying the indicating radiographic feature on the x-ray, and flowing a fluid through the access port at a rate of at least about 1 milliliter per second.08-27-2009
20090216215INSERTION DEVICE FOR INSERTION HEADS AND INFUSION SETS - An insertion device for applying an infusion set to the body of a patient, wherein the device has two actuation members which have to be actuated simultaneously to trigger an insertion movement by which a cannula of the infusion set is introduced into the body and wherein, in some embodiments, one of the actuation members is a securing slide including a contact face to be placed on the body of the patient, the securing slide being actuated by the insertion device being pressed, via the contact face, against the body of the patient.08-27-2009
20100130958Device and Methods for Subcutaneous Delivery of High Viscosity Fluids - The present invention provides infusion devices and methods for subcutaneous delivery of high viscosity fluids. The devices and methods described are innovative subcutaneous infusion systems that allow for the rapid delivery of viscous therapeutic fluids while avoiding adverse side effects and promoting patient comfort. The devices and methods described are also useful for rapid delivery of high volumes of therapeutic fluids.05-27-2010
20110152832NEEDLE SAFETY MECHANISM - A syringe needle safety apparatus comprising a syringe barrel having an open end and an opposite end adapted for a needle and a needle safety cover displaceable between a un-deployed state wherein the cover is constrained and the needle exposed, and a deployed state wherein the cover covers at least the needle tip. A plunger is slidably engaged in the syringe barrel and at least one element secures the needle safety cover in the un-deployed state. Biasing means urge the needle safety cover from the un-deployed state to the deployed state, and a housing is coupled to the opposite end of the syringe barrel, the housing comprising a corresponding securing member and a deformable member, the deformable member releasing the at least one element from the corresponding securing member upon receiving a releasing force via the plunger. During deployment, the needle safety mechanism provides for the needle safety cover to avoid contact with the needle, reducing or eliminating blood contact.06-23-2011
20110098675DEVICE FOR INJECTING A SOLID04-28-2011
20130158506CATHETER AND NEEDLE SYSTEM AND METHOD OF INSERTING A CATHETER - A system and method for inserting a catheter into a patient, the system comprising a frame including a catheter hub configured to provide a first anchoring point on a patient and receive a catheter insertable in the patient at an insertion site, a stabilization hub configured to provide a second anchoring point on the patient, and a flexible tubular lateral member, extending between the catheter hub and the stabilization hub; a fluidic channel configured to fluidically communicate with the catheter and transfer fluid to the catheter; a flush fluid source configured to couple to the fluidic channel and supply flush fluid to the catheter; a housing comprising a needle mount and a flash chamber; and needle having a distal end insertable through the frame and the catheter and a proximal end coupled to the needle mount, wherein the needle is configured to provide a fluid path to the flash chamber.06-20-2013
20110251586Subconjunctival agent delivery apparatus, system and method - A subconjunctival injection apparatus for administering a pharmacological agent formulation to a subconjunctival compartment of an eye, the apparatus including a jet injector having force generating means that is adapted to generate sufficient force to expel the pharmacological agent formulation from the jet injector and through the conjunctiva. In one embodiment of the invention, the jet injector comprises a needleless jet injector. In one embodiment, the needleless jet injector provides a delivery pressure in the range of approximately 100-1000 psi.10-13-2011
20110251587Syringe Housing To Facilitate Medication Injection - A syringe (10-13-2011
20110251585Sub-mucosal agent delivery, apparatus, system and method - An agent delivery apparatus for administering a pharmacological agent formulation to a sub-mucosal compartment of a body organ, comprising injector means having an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein and an elongated agent delivery member having a first end that is in communication with the internal formulation chamber and a second ejection end, the injector means including force generating means that is adapted to generate sufficient force to expel the pharmacological agent formulation from the injector means and into and through the agent delivery member, and out of the ejection end of the elongated agent delivery member. In one embodiment of the invention, the delivery-member comprises a needleless delivery member.10-13-2011
20110082441Bone Marrow Aspiration Needle - Disclosed is an aspiration assembly including an outer cannulated needle having a tip, a threaded collar, and an inner aspiration needle. A material can be aspirated through at least the inner aspiration needle. The distance that the tip of the inner aspiration needle extends from the tip of the outer cannulated needle changes when the inner aspiration needle is rotated relative to the outer cannulated needle.04-07-2011
20110077617Device for implanting objects into animal tissue - A device for implanting an object into animal tissue and a method for using the same device is provided. The device includes a cannula having a longitudinal axis, a passageway extending therethrough, a proximal end, and an opposite distal end that is insertable into tissue and defines an exit aperture for discharge of the object from the cannula. The device also includes an axially movable plunger disposed and oriented in a non-coaxial relationship within at least a portion of the cannula and a partial barrier disposed within the cannula adjacent to its distal end and configured to at least partially block the passageway, where the partial barrier at least partially defining an object receiving opening that is in communication with the passageway and sufficiently sized to receive the object and the plunger. When the device is in a first position, the partial barrier prevents the object from entering the passageway even when the plunger is inserted into the object receiving opening. When the device is moved to a second position, the passageway is aligned with the object, such that, upon movement of the plunger towards the distal end of the cannula, the plunger engages the object and pushes it through the object receiving opening towards and through the exit aperture.03-31-2011
20110077618Methods and Compositions for Treating Post-Cardial Infarction Damage - Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.03-31-2011
20110071494Intradermal Delivery Device - A system and method is provided for an injectable substance delivery device comprising a limiter, shoulder or post, that controls how deep the needle is inserted into the tissue. The limiter is sized in proportions that control the maximum insertion depth of the needle into the tissue without excessively restricting the complete insertion of the needle. The system and method further comprises an normalization or stabilizer ring that prevents distortion of the tissue in the vicinity of the infusion, so that the needle length is the major determining factor as to how deep the infusion is delivered.03-24-2011
20110071492HUB ASSEMBLY HAVING A HIDDEN NEEDLE FOR A DRUG DELIVERY PEN - A hub assembly for a pen injection device prevents a patient from seeing a needle of a hub assembly during an injection. A hub is connected to the pen injection device. A needle is received by the hub. A compressible member is connected to the hub and is compressible between a first position that entirely covers said needle and a second position that exposes the needle for an injection.03-24-2011
20120203197METHOD AND APPARATUS FOR ASPIRATION - An aspiration apparatus is described that includes a guide and a set of needles. The guide preferably has an approximately conical shape with a decreasing diameter in the distal direction. A plurality of lumens extend between a distal end portion and a proximal end portion of the guide. The needles have a tubular wall and are slidingly positionable in the lumens. The needles include a longitudinal section of the tubular wall that has a plurality of apertures that decrease in size in the proximal direction. The apertures define an approximately conically shaped area of harvest. The aspiration apparatus can connect to an external source of reduced pressure through the guide or directly to each needle.08-09-2012
20120302994THROUGH TIP FOR CATHETER - Catheter having an elongate tubular shaft including an inflation lumen and a guidewire lumen defined therein, the guidewire lumen extending along at least a distal length of an inner tubular member of the elongate tubular shaft. The catheter includes a distal tip member having a proximal end and a distal end, wherein the distal tip member is monolithic and the proximal end of the distal tip member is secured to a distal end of the inner tubular member. The catheter includes a balloon having a proximal portion and a distal portion, the proximal portion of the balloon sealingly coupled to the distal portion of the elongate tubular shaft. The distal portion of the balloon is sealingly coupled to the distal tip member and the balloon defines an inner chamber in communication with the inflation lumen, wherein the proximal end of the distal tip member is disposed within the inner chamber.11-29-2012
20120302993ANESTHETIC DELIVERY DEVICE - According to an example embodiment, a delivery device may include a needle and a pump operatively coupled to the needle, the pump having an expanded configuration and a collapsed configuration, the pump being biased to its expanded configuration such that fluid stored in the pump will exit the pump via the needle in response to pressure being applied to the pump, and in response to the pressure being released from the pump, the pump is configured to receive fluid from outside of the delivery device via the needle.11-29-2012
20120302992PNEUMATIC INJECTOR - This document discloses, among other things, an air-powered auto-injector device for subcutaneous delivery of a rescue drug. The device is configured for self-administered treatment of anaphylactic shock. Air is compressed by relative movement of a piston and a cylinder and released to subcutaneously drive an hypodermic needle.11-29-2012
20100262118Methods for Identifying Areas of a Subject's Skin that Appear to Lack Volume - The present embodiments relate to methods and systems for identifying areas of a subject's skin that lack sufficient volume. In some embodiments, this can be used to direct the administration of filler compositions or the application of techniques that increase the volume or firmness of the area. In some embodiments, the methods and systems provide for improved aesthetic benefit as well as suitability for instruction and training. In some embodiments, the methods are especially useful in the administration of dermal fillers to a subject.10-14-2010
20100280486SYSTEM AND METHOD FOR DELIVERING AND MONITORING MEDICATION - A method of delivering medication to a patient utilizing a medication delivery system is provided. A first medication to be delivered to the patient is supplied. The patient's identity is verified. The first medication is selected on a user interface to be delivered to the patient. The volume of the medication the patient will receive is entered. The first medication is injected into the patient through a flow sensor assembly. The flow rate and the volume of the first medication delivered to the patient are monitored by the flow sensor assembly while the injection occurs. A visual display provides information related to the injection. The method updates the patient's electronic medical administration record to capture the information regarding the injection of the first medication.11-04-2010
20100262120METHOD AND DEVICE FOR CONTROLLING DRUG PHARMACOKINETICS - Methods and devices for administration of substances into at least two compartments of skin for systemic absorption and improved pharmacokinetics, based on biphasic or bimodel kinetic profiling.10-14-2010
20100262119RETRACTABLE NEEDLE ASSEMBLY AND SYRINGE UTILIZING THE SAME - An injection device including a barrel, a hollow plunger having a portion structured and arranged to move within the barrel, a needle unit, and a safety system that one of automatically causes the needle unit to retract into the plunger when the plunger reaches a substantially fully depressed position and utilizes a frangible or breakable seal arranged within the plunger. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.10-14-2010
20110178501AUTOINJECTOR - An autoinjector including a housing, in which can be mounted a syringe having a plunger, a barrel and needle at one end thereof through which medicament can be delivered to an injection site; a syringe support means capable of causing said syringe to move therewith along an axial path with respect to said housing; biasing means capable of biasing said syringe support means so that said needle is normally inside said housing, blocking means selectively moveable by a user from a first position in which rearward movement of the syringe along said axial path is substantially prevented, to a second position in which rearward movement of the syringe along said axial path relative to said housing is possible and said biasing means causes said needle to retract inside said housing.07-21-2011
20110046601PUNCTURABLE MEMBRANE FOR SAFETY SYRINGE - A safety syringe may define a variable fluid chamber and detached needle assembly. The variable fluid chamber may be hermetically sealed off from the environment or ambient air until the needle assembly is attached to a syringe body of the safety syringe. A proximal end of the variable fluid chamber is sealed off from the environment via a seal between a piston and syringe body. The distal end of the variable fluid chamber may be sealed off from the environment via a barrier covering the distal end of the syringe body. The barrier may be punctured to allow fluid to through therethrough at or about the same time when the needle assembly is attached to the distal end portion of the syringe body.02-24-2011
20100004625FLOATING SPINAL CANNULA AND METHOD OF USE - A spinal cannula for delivering a therapeutic agent to a spinal cord target includes proximal and distal end portions, a middle portion, and a deployable cannula member having distal and proximal end portions and a first lumen extending between the end portions. The spinal cannula includes a fluid delivery line operably connected to the proximal end portion of the deployable cannula member, and a fluid delivery line including a second lumen in fluid communication with the first lumen. The spinal cannula includes a support cannula proximally located from the deployable cannula member and securely connected to a portion of the fluid delivery line. Additionally, the spinal cannula includes a delivery cannula having distal and proximal end portions and a third lumen extending between the end portions for receiving the support cannula. The proximal end portion includes a locking mechanism for releasably engaging the proximal end portion of the support cannula.01-07-2010
20120203198Nighttime Basal Dosing Device - A basal hub for attaching to an infusion base is disclosed. The hub includes a fluid reservoir and pressure actuating device. A septum portion of the reservoir is configured to be opened by a flow cannula that is in fluid communication with an infusion cannula of the infusion base, when the basal hub is attached to the infusion base. The pressure actuating device applies pressure to the fluid reservoir, such that when the septum portion of the fluid reservoir is pierced by the by the flow cannula, liquid stored in the fluid reservoir is released from the fluid reservoir into the infusion cannula of the infusion base via the flow cannula. The basal hub is configured to deliver a basal dose of insulin during periods of inactivity, such as during sleep time.08-09-2012
20090118698DEVICE AND METHOD FOR APPLYING AN ACTIVE INGREDIENT TO THE SKIN - The invention relates to a device and a process for introducing an active ingredient into the skin. The device comprises a roller that is mounted to rotate around the longitudinal axis thereof and on whose outside peripheral surface a number of needles project radially outward. After the active ingredient has been applied on the skin, the roller rolls over the skin. In this case, the needles penetrate the skin and open up fine channels there, through which the active ingredient penetrates through the epidermis up to the dermis.05-07-2009
20090143763ROTATABLE INFUSION SET - An arrangement for introducing a liquid into the body of a patient or for withdrawing a liquid from the body of a patient, including a first structural part carrying a cannula for positioning in the body of the patient, and a second structural part with a connection port for detachably coupling a conduit for supplying or withdrawing a liquid, wherein the first and second structural parts are connected, can be rotated relative to each another and in relative rotational positions form a channel for introducing a liquid from the conduit to the cannula or for withdrawing a liquid from the cannula to the conduit, and whereby movement of the conduit for coupling and uncoupling is transverse to the longitudinal axis of the cannula.06-04-2009
20090143762Methods and Compositions for Enhancing the Viability Of Microneedle Pores - Described herein is a method of transdermally administering one or more pharmaceutically active agents to a mammal. The method comprises administering one or more active pharmaceutical agents to the skin of the subject, in conjunction with microneedles and one or more COX inhibitors, whereby the COX inhibitors facilitate the absorption of the active pharmaceutical agents by prolonging the pore opening created by the application of the microneedle.06-04-2009
20080275424METHODS AND DEVICES FOR TREATMENT OF OBESITY - The present invention provides methods and systems for treating obesity by creating an interruption of the vagal nerve, preferably in the region of the esophagus, by minimally or noninvasive means.11-06-2008
20090088722Straight Insertion Safety Infusion Set - An infusion set assembly comprising a cannula housing having a base surface and a septum housing adapted to be pivotally attached to the cannula housing for movement between a position where an axis thereof is substantially perpendicular to the base surface and a position where the axis is substantially parallel to the base surface. The infusion set assembly further comprises an insertion needle assembly including an insertion needle and a cannula supported by the needle assembly with a tip of the insertion needle extending from a distal end of the cannula. An insertion guide housing is configured to support the insertion needle assembly with the needle substantially perpendicular to the base surface and adapted for movement between a position where the needle tip and cannula distal end are spaced from the base surface and a position where the needle tip and cannula distal end extend beyond the base surface.04-02-2009
20080319413PERCUTANEOUS ARRAY DELIVERY SYSTEM - A system for treating tissue includes a cannula having a proximal end, a distal end, and a lumen extending between the proximal and the distal ends, and an array of delivery tubes at least partially disposed within the lumen, each of the delivery tube having a lumen, wherein each of the delivery tubes is slidable relative to the cannula, and has a first configuration when inside the lumen, and a second configuration when outside the lumen. A system for treating tissue includes a treatment device having a distal end, and an indexing device for controlling a longitudinal position of the distal end of the treatment device relative to a target tissue region, the indexing device having a tubular portion for receiving the treatment device.12-25-2008
20080275425METHOD OF CONTROLLING A MEDICATION DELIVERY SYSTEM WITH A REMOVABLE LABEL CONTAINING INSTRUCTIONS FOR SETTING MEDICATION DELIVERY RATE OVERLYING A SECOND LABEL WITH PATIENT INSTRUCTIONS - A method of controlling a medication delivery system is used to deliver medication to a patient. The system includes an electronic controller, at least one control button, a patient label, and a removable overlay label disposed on top of the patient label for controlling an amount of the medication to be delivered to the patient. The method comprises the steps of selecting the amount of the medication in accordance with a first set of explanatory indicia on the removable overlay label; locking the system such that the selected amount of the medication to be delivered to the patient is unable to be modified; removing the removable overlay label to reveal the patient label; and operating the system in accordance with a second set of explanatory indicia on the patient label.11-06-2008
20110257628INSTRUMENT FOR ALLEVIATING ADDICTIVE DRUG CRAVING, METHOD FOR USING SAME AND METHOD FOR TREATING ADDICTIVE DRUG DEPENDENCE - Provided is an instrument for alleviating addictive drug craving which can be safely administered to an addictive drug-dependent patient by a definite method in practice without causing any undesirable effects on therapy and terminate a series of behaviors through the administration so as to achieve an excellent effect on the therapy for alleviating addictive drug craving. An instrument for alleviating addictive drug craving (10-20-2011
20120203200DEVICE AND METHOD FOR DELIVERING MEDICINE INTO THE TYMPANIC CAVITY - A device for substance delivery to and/or extraction from the tympanic cavity, comprising: a housing, having a distal surface, a proximal surface that is opposite to the distal surface, and a circumscribed surface that connects the distal surface and the proximal surface; at least one piercing element having at least one proximal piercing end and at least one distal piercing end, disposed within the housing in such manner that the at least one distal piercing end is/are generally facing the distal surface of the housing; and a means for flexing the tympanic membrane toward the distal end of the at least one piercing element.08-09-2012
20110054442Cell Membrane Translocation of Regulated Snare Inhibitors, Compositions Therefor, and Methods for Treatment of Disease - Compositions and methods of modulating cellular function and treatment of disease in mammals comprising locally administering a regulated SNARE inhibitor and a translocating agent to the mammal. Regulated SNARE inhibitors include clostridial neurotoxins, tetanus neurotoxin and their free light chain portions and IgA protease. Translocating agents include acids, encapsulating vectors, and transduction domains.03-03-2011
20110054441METHODS, DEVICES, AND COMPOSITIONS FOR INTRAVITREAL INJECTION - Methods of treating disorders of the eye are disclosed. One or more substances are injected into the vitreous humor of the eye using a syringe. A needle of the syringe is inserted into the eye such that the tip of the needle is positioned inferior to the visual axis. The needle of the syringe is inserted into the eye at an injection point that is located from 3 mm to 5 mm posterior to the limbus of the eye. The tip of the needle is positioned at a depth from 1 mm to 10 mm from the retina of the eye at the injection point.03-03-2011
20110054440DISINFECTING MALE LUER CONNECTOR CAPS - A system and method for disinfecting an exposed portion of a female luer connector is disclosed. A male luer connector coupled to a male luer connector cap is provided where the male luer connector cap has a chamber containing a disinfectant and a sealing member for sealing the disinfectant in the chamber. The chamber is at least partly opened and the disinfectant exposed by movement of the sealing member. An exposed surface of a female luer connector is caused to come in contact with the disinfecting fluid in the chamber prior to the female luer connector mating with the male luer connector.03-03-2011
20110264072TRANSSEPTAL ACCESS DEVICE AND METHOD OF USE - Systems, devices, and methods are provided for transseptal access of septa within a patient. The device can be advanced to a septum, e.g., towards a fossa ovalis. Instead of applying positive pressure to “tent” the septum, a negative pressure is applied to a lumen within a sheath, e.g., within an elongated member slidable within the sheath, via a negative pressure source such as a syringe on the proximal end of the sheath. This results in the septum pulling inward. The sheath employs a stationary needle-like central core component contained within the lumen of the sheath that punctures the septum when the same is pulled passed it by the negative pressure. The stationary needle-like central core component may be hollow and may form a portion of the elongated member or may be coupled to a distal end thereof.10-27-2011
20080234655Electroporation device and injection apparatus - An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising: a hollow needle; and fluid delivery means, wherein the apparatus is adapted to actuate the fluid delivery means in use so as to automatically inject fluid into body tissue during insertion of the needle into the said body tissue.09-25-2008
20110118702DEVICE FOR LOCATING EPIDURAL SPACE WHILE SAFEGUARDING AGAINST DURAL PUNCTURE THROUGH DIFFERENTIAL FRICTION TECHNIQUE - A device for locating a cavity within two walls including a syringe including a syringe piston slideable in a first syringe barrel for discharging air or fluid contained in the first syringe barrel on forward movement of the syringe piston into the cavity, the first syringe barrel being attached to a hub of a needle cannula; and a frame which at least in part encases the syringe and which is solely connected to the back of the syringe piston.05-19-2011
20110118701Dose Dividing Delivery Device - A simple method and device enabling a unit dose from a reservoir is provided. The dose is drawn into the reservoir and is then expelled from the device by depressing the plunger. The plunger (05-19-2011
20110118700ADMINISTRATION DEVICE COMPRISING INDICATION UNIT AND METHOD FOR SETTING A DOSE - An administration device for the administration of a liquid drug in adjustable doses may comprise an injection unit and an electronic indication unit. The injection unit may comprise a dosing mechanism and a manually operated dose setting component. The manually operated dose setting component may adjust the dosing mechanism to administer an administration dose amount of the liquid drug. The electronic indication unit may indicate a relationship between the administration dose amount and a target dose amount. A method for setting a dose of a liquid drug for administration may comprise providing an administration device, operating a manually operated dose setting component of the administration device, and continuing to operate the dose setting component until an electronic indication unit indicates that the administration dose amount is equal to the target dose amount.05-19-2011
20110046606Catheter injectable depot compositions and uses thereof - Catheter injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions are have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.02-24-2011
20110046605NEEDLE SHEATHING DEVICE WITH FLEXIBLE END-PIECE FOR SYRINGE - The invention relates to a safe support device for a syringe, said support comprising a support sheath for the body of a syringe, and safety means which comprise an inner sheath suitable for sliding relative to said support sheath between a waiting retracted position, in which said inner sheath is substantially retracted inside said support sheath, and an active protection position, in which said inner sheath projects from said support sheath. The inner sheath has a free end portion formed by a flexible end-piece. The invention also relates to an assembly comprising such a safe support device and a syringe having a body, a piston and a needle disposed at one end of said body.02-24-2011
20110046604Syringe Assembly with Inverse Delivery - A reduced profile syringe assembly is provided that includes an overall profile that is substantially similar to the profile of the syringe barrel. The syringe assembly includes a plunger rod that is significantly disposed within the syringe barrel when filled for use, with the plunger rod adapted to be retracted from the syringe barrel during dispensing of the contents of the syringe barrel.02-24-2011
20110046603Syringe Assembly with Pivoting Plunger and Integral Tip Guard - The invention provides a syringe assembly comprising a syringe barrel having an inside surface defining a chamber, an open proximal end, and a distal end having an opening therethrough. An elongated plunger rod extends between a first end and a second end, with a cap or guard disposed on the first end of the plunger rod. A plunger head extends within the chamber of the syringe barrel, and is adapted for slidable movement within the syringe barrel between the proximal end and the distal end, with the second end of the plunger rod connected with the plunger head through a pivotable connection. The plunger rod is adapted to pivot with respect to the plunger head between a first position in which the guard is adjacent the distal end of the syringe barrel and a second position in which the plunger rod is in general axial alignment with the syringe barrel, and is further adapted for axial movement so as to cause sliding movement of the plunger head through the syringe barrel to expel the contents thereof.02-24-2011
20110046602DEVICES AND METHODS FOR FLUID ADMINISTRATION - Improved fluid delivery devices and systems are disclosed, including drug delivery devices and systems, and methods that permit, inter alia, the rapid sequential delivery of two or more fluids to a single external fluid flow or intravenous line.02-24-2011
20100217230Systems, Devices and Methods for Fluid/Drug Delivery - Fluid delivery systems, methods and devices for delivering a therapeutic fluid to the body of the patient are disclosed. A fluid delivery device for delivering fluid to the body of the patient includes a housing having an upper wall and a lower wall, wherein the upper wall includes an upper opening and the lower wall includes a lower opening, a well-arrangement mechanism configured to be disposed inside the housing and between the upper wall and the lower wall and including a tubular member having a bore, wherein the bore is configured to be disposed between the upper opening and the lower opening, and a penetrating cartridge for delivery of therapeutic fluid to the body of the patient, wherein the penetrating cartridge is configured to engage the bore following its insertion through the upper opening and the lower opening, wherein therapeutic fluid is configured to be delivered through the tubular member into the penetrating cartridge into the body of the patient when the penetrating cartridge engages the bore.08-26-2010
20100324531APPARATUS AND METHODS FOR INJECTING HIGH VISCOSITY DERMAL FILLERS - A method includes inserting a distal end portion of a needle of a medical injector into a skin of a body. An energy source operatively coupled to the medical injector is actuated such that a dermal filler is conveyed from the medical injector into the skin through the distal end portion of the needle. The distal end portion of the needle is moved within the skin during the actuating.12-23-2010
20100324529IMPLANT PELLETS AND METHOD USING SAME - A system comprising a plurality of implantable pellets, wherein one such implantable pellet delivers localized, controlled and sustained release of a predetermined quantity of one or more pain relief agents, in optional combination with one or more anti-inflammatory agents, one or more polymeric excipients, and/or one or more surfactants. An anesthetic/analgesic pellet is used in combination with one or more pharmaceutical pellets as part of a single procedure to provide desired a pharmaceutical to the animal while simultaneously alleviating pain and, optionally, inflammation at the injection site.12-23-2010
20100324528DOSE SETTING MECHANISM FOR PRIMING A DRUG DELIVERY DEVICE - A method and system for priming a drug delivery device. The drug delivery device includes a dose dial sleeve and an internal housing portion. The dose dial sleeve is coupled to the internal housing. The dose dial sleeve rotates on a substantially circumferential rotational path during priming of the drug delivery device. Further, the dose dial sleeve rotates on a helical path during dose setting of the drug delivery device.12-23-2010
20100179509INTRATHECAL CATHETER HAVING A STYLET WITH A CURVED TIP AND METHOD OF USE - An apparatus includes a catheter for an intrathecal drug delivery system and a stylet having a curved forward end. Preferably, the curved forward end has a shape in the form of a “J” or a “C.” Also preferably, the catheter has a distal end that conforms to the curved forward end of the stylet. Thus, the present invention provides a catheter having a blunt forward end that minimizes the risk of penetrating the substance of the spinal cord. Additionally, the curved forward end of the stylet can be formed of a springy material so that it straightens out during the processes of insertion through a guide needle and retraction from the needle.07-15-2010
20110152831Peristaltic Pump with Linear Flow Control - A peristaltic pump includes a conduit having a first end for receiving a fluid from a reservoir and a second end for delivering the fluid. A plurality of fingers are disposed at respective locations along a segment of the conduit and are configured to alternately compress and release the conduit at the locations. A cyclical pump mechanism is coupled to move the fingers between respective compressed and released positions in a spatio-temporal pattern so as to drive a predetermined quantity of the fluid through the segment of the conduit in each pump cycle. A motor is coupled to drive the pump mechanism. A controller is coupled to activate and deactivate the motor in alternation during each pump cycle with a duty cycle that varies within the pump cycle.06-23-2011
20110137287MULTI-CARTRIDGE FLUID DELIVERY DEVICE - A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments.06-09-2011
20110137286INJECTION DEVICE FOR SOFT-TISSUE AUGMENTATION FILLERS, BIOACTIVE AGENTS AND OTHER BIOCOMPATIBLE MATERIALS IN LIQUID OR GEL FORM - Described herein are injection devices capable of automatically injecting substances into the soft tissue of a patient. The devices can inject low to high viscosity materials at predetermined, user selected injection rates, allowing the operator more control than a traditional syringe. The devices can allow mixing of more than one substance and/or reconstitution of a solid substance for injection. The injection devices described herein can allow the operator to easily inject one or more low to high viscosity liquid or gel soft-tissue augmentation fillers, one or more drugs, one or more other biocompatible materials, or combinations thereof.06-09-2011
20110137285KIT OF TAMPONING LIQUIDS AND A METHOD FOR THE TREATMENT OF TEARS AND/OR DETACHMENTS OF THE RETINA USING SUCH LIQUIDS - A kit of tamponing liquids comprising a first liquid having a density lower than 1.00 g/cm06-09-2011
20110178502CELL THERAPY FOR LIMITING OVERZEALOUS INFLAMMATORY REACTIONS IN TISSUE HEALING - Cells of the B cell lineage including pre-pro-B cells, pro-B cells, pre-B cells, immature B cells, and some mature B cells, and/or cells of the T cell lineage, especially those with helper or regulatory function, most preferably autologous to the recipient, can be transplanted into damaged tissue to enhance recovery following injury. In a preferred embodiment, the cells are selected based on those cells which appear at the site of injury a few days after injury, such as macrophages, lymphocytes, which accelerate clean up and repair of the injured site and to mitigate the overzealous inflammatory response, presumably by inhibiting the inflammatory cells such as neutrophils and signals released thereby immediately following injury.07-21-2011
20120209249Injection Arrangement for a Flowable Drug - The invention refers to an injection arrangement (08-16-2012
20120209246System and Method for Pain-Free Injections - A system for administering pain-free injections includes an electric current source having at least two electrodes attached adjacent an injection site, the electric current source producing a variable numbness pattern and providing a frame of reference for identifying a plurality of sub-areas of the injection site; and a probe applied to the plurality of sub-areas of the injection site for pain-response testing, wherein one or more areas of numbness in the variable numbness pattern are identifiable according to the plurality of sub-areas of the injection site. A fence may be removably applied to the injection site and provide a frame of reference for identifying a plurality of sub-areas of the injection site, and may aid in identifying one or more areas of numbness in the variable numbness pattern. The fence may be removably applied to the injection site via a belt or manual pressure.08-16-2012
20100191217INJECTION DEVICE WITH A SPRING FOR A NEEDLE PROTECTING SLEEVE - An injection device including a housing, a needle guard sleeve displaceable relative to the housing, and a spring coupled to the guard sleeve such that the guard sleeve can be moved by the spring distally from a proximal position to an end position, the spring also being coupled to a forward drive element displaceable relative to the housing in a drive direction wherein the spring is tensioned upon a movement of the forward drive element in the forward drive direction.07-29-2010
20100191218INFUSION DEVICE AND METHOD FOR INFUSING MATERIAL INTO THE BRAIN OF A PATIENT - A fluid infusion device and a method of using the same. The device includes an outer, flexible guide catheter having a distal end for introduction beneath the skull of a patient and a proximal end remaining external of the patient. A flexible infusion fiber is located within the guide catheter and has a distal end extending outwardly from the guide catheter to be located in a target area within the patient's brain. The infusion fiber can be fixed or axially movable within the guide catheter. In the latter embodiment, the proximal end of the infusion fiber extending outwardly from the guide catheter can be manipulated to locate the distal end of the infusion fiber in the target area. An infusion pump is connected to the proximal end of the infusion fiber to infuse a minute quantity of fluid at an extremely low flow rate into the brain of the patient.07-29-2010
20110190726Method and apparatus for micro-needle array electrode treatment of tissue - Systems and methods for revitalizing aging skin using electromagnetic energy that is delivered using a plurality of needles that are capable of penetrating the skin to desired depths. A particular aspect is the capability to spare zones of tissue from thermal exposure. This sparing of tissue allows new tissue to be regenerated while the heat treatment can shrink the collagen and tighten the underlying structures. Additionally, the system is capable of delivering therapeutically beneficial substances either through the penetrating needles or through channels that have been created by the penetration of the needles.08-04-2011
20110190725METHOD FOR ALTERING DRUG PHARMACOKINETICS BASED ON MEDICAL DELIVERY PLATFORM - A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm.08-04-2011
20110152834SAFETY DEVICE FOR DRUG DELIVERY DEVICES AND CONTAINERS - A drug administration safety device having a label configured to be attached to a drug container such as a syringe or IV bag, an adhesive on the back face of the label, and a backing or substrate for holding the label and protecting the adhesive prior to the application of the label to the drug container. In one embodiment, the label includes a first drug name section in a first orientation, a second drug name section in a second orientation, a third drug name section in a third orientation, a drug concentration section, a variable information section, and a gradiation viewing section. The first orientation, second orientation, and third orientation are different from each other to enable a user to readily see the drug name regardless of the position and orientation of the drug container.06-23-2011
20110202035Syringe Assemblies Having Detachable Needle Assemblies and Low Dead Space - The present invention is directed to syringe assemblies comprising detachable needle assemblies, that are configured in such a manner as to minimize the dead space after deployment of the syringe piston and injection of the material in the syringe into a patient's body, as well as with bevel indicators that provide guidance as to optimal angles at which to inject the needles into patients.08-18-2011
20120172836IMPLANTABLE DEVICE FOR PRODUCTION OF INTERLEUKIN-1 RECEPTOR ANTAGONIST - Treatments and devices for generating and using interleukin-1 receptor antagonist (IL-1ra). An implantable device is loaded with adipose tissue and/or white blood cells and inserted into an inflammation site in a patient to produce interleukin-1 receptor antagonist in vivo. The implantable device has an enclosed or substantially enclosed body that defines an internal space. At least a portion of the body comprises a first bioresorbable material and a second bioresorbable material is within the internal space along with one or more voids. The second bioresorbable material includes an activation surface to activate adipose tissue and/or white blood cells loaded into the device to produce IL-1ra.07-05-2012
20100016830Injection of Anticoagulant Into Bone Marrow Space - A method for aspirating bone marrow includes the step of injecting anticoagulant into the area Of the bone marrow cavity surrounding the entry site of the aspiration needle. The amount of anticoagulant may be relatively small because the primary objective is to address the damage caused by entry of the needle into and through regions of the bone marrow cavity. As little as 0.5 ml heparin is injected prior to aspiration. Additional anticoagulant is provided in the collection syringe to facilitate further processing, as by centrifugal fractionation of the marrow to obtain desired components.01-21-2010
20100016829APPARATUS AND METHODS FOR RETAINING A NEEDLE ON A MEDICAL INJECTOR - Medical injectors are described herein. In some embodiments, an apparatus includes a medicament container, a needle assembly, a coupler, and a retainer. The medicament container has a distal end and a proximal end and is configured to contain a medicament. The coupler is configured to couple the needle assembly, which includes a needle and a hub, to the distal end of the medicament container. The retainer is configured to be coupled to the needle assembly and the medicament container. The retainer is configured to limit the movement of the needle assembly when the coupler fails to maintain the position of the needle assembly relative to the distal end of the medicament container.01-21-2010
20130012918STEADY GRIP OPHTHALMIC SURGICAL SYRINGE AND METHOD - A disposable hypodermic syringe for stable one-handed dispensing of fluids and precision positioning comprises a hollow barrel for retaining fluid. The barrel has proximal end, a midpoint, and a distal end, and a proximal end. At least one forward barrel flange is fixedly formed around or connected to the barrel and positioned at a point between the midpoint and the distal end of the barrel.01-10-2013
20090198214Butterfly Needle Devices and Methods Relating Thereto - In accordance with one embodiment of the present disclosure, a butterfly needle device is described. The device comprises a needle having a proximal end and a distal tip, a base positioned over the needle, a first wing and a second wing each extending from the base and being configured to move between a generally abducted position and a generally adducted position, a spacer element extending from the first wing, a sleeve positioned over the needle, and a bridge element connecting the sleeve to the base.08-06-2009
20110152833APPARATUS AND METHODS FOR TREATING TISSUE USING PASSIVE INJECTION SYSTEMS - Methods and apparatus are provided for treating damaged tissue using apparatus that atraumatically delivers a bioactive agent within the tissue, wherein the apparatus provides a column of stem cells may be advanced simultaneously with a needle during needle insertion, and then held stationary or injected at low pressure while retracting the needle. Alternatively, the needle may employ electromotive forces, or to change a dimension of the needle, to expel the bioactive agent into the needle track.06-23-2011
20110306947MEDICATION DELIVERY DEVICE AND METHOD FOR OPERATING A MEDICATION DELIVERY DEVICE - A medication delivery device comprises a housing having a proximal end (P) and a distal end (D), a cartridge for holding a medication (M), the cartridge having an outlet, a moveable piston being retained within the cartridge, a drive member moveable in a proximal direction with respect to the housing for setting a dose of medication (M) to be delivered and in the distal direction with respect to the housing for delivering the dose and a piston rod adapted to drive the piston in a distal direction with respect to the cartridge for delivering the dose. The drive member is releasably coupled to the piston rod. The medication delivery device further comprises a resilient member which is arranged to move the drive member in the proximal direction with respect to the housing after dose delivery, thereby reducing pressure of the piston rod on the piston.12-15-2011
20080208163Use of Reverse Thermosensitive Polymers to Control Biological Fluid Flow Following a Medical Procedure - One aspect of the present invention relates to a method to control biological fluid flow at a site in a mammal by use of an in situ formed polymer plug. In certain embodiments, the present invention relates to a method to control bleeding following a catheterization procedure, a method to control leakage of cerebral spinal fluid following a lumbar puncture, a method to seal a fistula, or a method to control the flow of serous fluid after a lymphadenectomy. In certain embodiments, the polymer plug is generated in situ by temperature changes, pH changes or ionic interactions. In certain embodiments, the polymer plug comprises at least one optionally purified reverse thermosensitive polymer.08-28-2008
20120041417User-Actuated Storage Assembly For Injection Device - A storage assembly is removably connectable to a drug delivery device. A first chamber is disposed in the housing. A plurality of penetrating members are stored in the first chamber. A second chamber is disposed in the housing for storing the plurality of penetrating members after being used in an injection. A transfer drum disposed in the housing transfers one of the penetrating members from the first chamber to an injection position and from the injection position to the second chamber following an injection.02-16-2012
20110306946CELL COMPOSITIONS AND USES THEREOF - The present invention relates to blood serum and dermally-derived cells for use in tissue repair. Particularly it relates to blood serum and collagen producing cells for use in the treatment of connective tissue injuries. Preferably the cells and the blood serum are autologous and the connective tissue to be repaired is a tendon or ligament. Also provided is a method of treating connective tissue injuries by the administration of blood serum and collagen producing cells directly to the site of injury. It also relates to the use of blood serum and muscle-like cells for use in the treatment of muscle injury, particularly skeletal muscle injury.12-15-2011
20090275917SKIN TREATMENT SYSTEM AND METHOD - A skin treatment system is provided for applying liquid medication through a controlled intra-dermal injection. The skin treatment system includes a microinjector unit with a proximal end and an opposing distal end. The proximal end of the microinjector unit may be press fitted or twist fit to a distal end of a tube via a luer lock mechanism. A fluid moving chamber is disposed within the microinjector unit. The fluid moving chamber is configured to receive liquid medication and distribute the liquid medication to a plurality of hypodermic needles. The plurality of hypodermic needles are operative for receiving the liquid medication from the fluid moving chamber and delivering the liquid medication to the skin of the patient. The plurality of hypodermic needles extends from the distal end of the microinjector unit. The distal end of the microinjector unit may encompass a variety of different shapes while the needles are maintained equidistantly spaced apart.11-05-2009
20100318060Injection Device With Rotatable Dose Setting - An injection device comprising a housing and a dose setting mechanism including a dose setting element. Contrary to prior art injection devices, the dose setting element can only be set at a few different dose settings. This is established by forming the dose setting element as a rotatable dish concealed within the housing and having a number of projections projecting outside the boundaries of the housing through a slot in the housing. A dose is set by activating a projection which in addition provides the user with a tactile guidance. Usually one projection is provided for one dose setting limiting the number of doses to be set to the number of projections.12-16-2010
20110112509MICRONEEDLE DEVICE, AND METHOD FOR ENHANCING THE EFFICACY OF INFLUENZA VACCINE BY USING MICRONEEDLE DEVICE - The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.05-12-2011
20110112508Drug Delivery Devices, Systems, and Methods - This disclosure relates to drug delivery devices, systems, and methods. In some aspects, a drug delivery device includes an elongate member defining a fluid passage and an opening in fluid communication with the fluid passage, and a projection extending radially from the elongate member. A portion of the elongate member extending axially from the projection to a distal end of the elongate member has a length sufficient to allow the distal end of the elongate member to reach subdermal tissue of a patient when the elongate member is inserted into the patient and the projection is in contact with an outer surface of skin of the patient, and the opening is positioned at a location along the elongate member such that the opening is disposed within a dermis of the patient when the elongate member is inserted into the patient and the projection is in contact with the outer surface of the skin of the patient.05-12-2011
20120041416DRUG DELIVERY DEVICE FOR FLUID RESTRICTED PATIENTS - A syringe assembly for connecting to an intravenous (“IV”) line includes: a syringe barrel having an actuation end and a discharge end; a syringe plunger moveable within the syringe barrel, the syringe plunger including a plunger head connected to a plunger arm; a seal between the plunger arm and the syringe barrel, the seal residing on an actuation end side of the syringe plunger; and a tube in fluid communication with the syringe barrel at a location between the seal and the plunger head, the tube having a distal end configured to be connected to the IV line.02-16-2012
20100324530HOLLOW NEEDLE - The present invention is a hollow needle for attachment to a syringe, through which a liquid can be delivered to the stratum granulosum and/or beneath the epidermis, preferably to an area consisting from the stratum granulosum (included) to reticular dermis (included) and more preferably beneath the papillary dermis during a cosmetic procedure, the needle comprising a distal tip and including a lateral aperture adjacent to the distal tip, wherein the liquid exits the needle via the lateral aperture, and wherein the needle is flexible. Apparatus comprising a needle of the invention and a syringe, and a method of use thereof, is also provided.12-23-2010
20090204101METHOD OF APPLYING AN INJECTABLE FILLER - Methods for applying injectable fillers are provided. In some embodiments, the methods can result in a reduced risk of an adverse event occurring from the administration of the injectable filler. Also disclosed are devices and kits related to this method.08-13-2009
20120209248DEVICES AND METHODS FOR TISSUE TRANSFER - Devices and methods for tissue transfer are described where a cannula may be inserted into the breast of a subject at one of several points of entry. Insertion of the cannula into the breast may be accomplished by using a guidance system to distinguish between tissue types. Once desirably positioned, the cannula may be withdrawn from the breast while automatically (or manually) injecting the fat in multiple deposits of adipose tissue or fat such that the deposited fat remains within the tract formed by the withdrawn cannula. Multiple tracts of the deposited fat may be injected within the breast until the breast has been desirably remodeled and/or augmented.08-16-2012
20120046643INJECTION DEVICE - An injection device (02-23-2012
20120004641DUAL-CHAMBERED DRUG DELIVERY DEVICE FOR HIGH PRESSURE INJECTIONS - A dual-chambered drug delivery device (01-05-2012
20120004640OPEN AND CLOSED VALVE MEDICATION DELIVERY SYSTEM FOR HIGH PRESSURE INJECTIONS - A dual-chambered drug delivery device (01-05-2012
20120004639MULTI-STROKE DELIVERY PUMPING MECHANISM FOR A DRUG DELIVERY DEVICE FOR HIGH PRESSURE INJECTIONS - A dual-chambered drug delivery device (01-05-2012
20120004638DRUG DELIVERY DEVICE WITH NEEDLES AND ROLLER - A delivery device including a roller rotatably mounted on an axle, a reservoir, and at least one hollow needle positioned in the roller are in fluid communication with the reservoir, wherein as the roller rotates about the axle, contents of the reservoir pass through the at least one hollow needle.01-05-2012
20120310208DEVICE FOR ADMINISTERING A FLUID PRODUCT - An administering device for a fluid product includes a product receptacle that accommodates the product to be administered, a fluid reservoir for a driving fluid, a driving means, a product chamber, and a fluid connection. The product receptacle includes an opening at a forward end and a product stopper at a rear end. The driving means acts upon the fluid reservoir, the pressure chamber adjoins the product stopper while the fluid connection is located between the fluid reservoir and the pressure chamber, and the driving means acts upon the fluid reservoir in such a way that the pressure chamber is impinged upon by pressure which affects the product stopper and the product is discharged from the product receptacle.12-06-2012
20120310207SYRINGE WITH NEEDLE GUARD INJECTION DEVICE - The present invention provides for an injection device including a syringe with a proximal end, a distal end, a needle extending from the distal end, and a plunger inserted into the proximal end. A guard is slidable on the syringe, has a proximal end, a distal end, and is biased from a first position wherein the needle is exposed towards a second position wherein the guard covers the needle. The injection device includes first and second sets of cooperating detents for retaining the guard and syringe in the first and second positions, respectively. A latch member extends proximally from the guard that is engageable by the plunger as the plunger is depressed to release the first set of cooperating detents. Upon release, a spring element biases the guard towards the second position until the second set of cooperating detents engage and secure the guard in the second position.12-06-2012
20120310206Injection Device - An injection device (12-06-2012
20120209247Safe Disposable Injector with Changeable and Automatically Retractable Needle - A safe disposable injector with a changeable and automatically retractable needle includes a needle cylinder (08-16-2012
20090043280Vaccine Delivery Service - The present invention relates to novel methods of vaccination and vaccine delivery. In particular, the invention relates to methods of vaccination and pre-filled vaccine delivery devices designed to deliver the vaccine into the dermis of an individual02-12-2009
20120010594Drug Delivery Device - A drug delivery device includes a housing having an interior space, a needle having retracted and deployed states, an injector to move the needle between retracted and deployed states, and a reservoir disposed within the interior space, the reservoir configured to receive a volume of a drug and to be in fluid communication with the needle. The drug delivery device also includes a controller coupled to the injector and the reservoir, and configured to actuate the injector to move the needle from the retracted state to the deployed state only once, and to actuate the reservoir to deliver the volume of the drug to the patient as a single bolus after a preselected time period has elapsed, the controller disposed within the interior space and configured prior to being disposed within the interior space. The delivery device is wearable, disposable, and single-use.01-12-2012
20120010595IMMOBILIZING OBJECTS IN THE BODY - Stabilizing an object in the body of a patient involves the injection of a lower critical solution temperature (LCST) material or other flowable material into the body of the patient so that the material contacts the object. The LCST material or other flowable material then forms a gel in the body such that the object is contained at least partially within the gel and thereby stabilized by the gel such that the object can then be easily fragmented within the body and/or retrieved from the body.01-12-2012
20120010593Method and apparatus for a strategic nerve antidote pouch - A strategic nerve antidote pouch includes a backing, a loop panel secured to the backing, first and second straps secured to the backing, and an injector pouch member secured to the backing. The injector pouch member includes first, second, and third injector pouches that receive single nerve antidote injectors therein thereby providing the maximum allowable number of single nerve antidote injectors. The first, second, and third injector pouches provide a visual indication of the number of single nerve antidote injectors employed once a single nerve antidote injectors has been removed, injected, and discarded. The loop panel aids in preventing an accidental injection by a single nerve antidote injector, while the first and second straps along with the loop panel facilitate securing of the strategic nerve antidote pouch with a wearer's body. The strategic nerve antidote pouch further includes a protection edge mounted over a lower portion of the first, second, and third injector pouches to aid in preventing an accidental injection by a single nerve antidote injector.01-12-2012
20120016338CHEMOABLATION OF TISSUE USING BIODEGRADABLE, SOLID SALT DOSAGE FORMS - Novel methods for the chemical ablation of tissue (e.g. prostatic tissue) are described. These methods include the steps of: (a) providing one or more solid salt dosage form comprising 50-100% w/w salt; and (b) inserting one or more of such solid salt dosage forms into the tissue. The solid salt dosage form is optionally inserted into the tissue under real-time ultrasonic observation. An advantage of the present invention is its ability to eliminate toxic byproducts. For example, where NaCl-based solid salt dosage forms are used to effect localized chemical ablation, the concentration is ultimately reduced to the level of normal saline (i.e., about 0.9%) upon absorption by the body of the subject being treated.01-19-2012
20120016337Collection canister apparatus for closed loop fat harvesting system and method of use thereof - An improved collection canister and method of its use for a closed loop fat harvesting system is disclosed. The collection canister comprising of a main body with inner cavity, handles on each sides, a detachable lid that includes at least two liposuction lure ports, a vacuum port to provide suction within the main body and an additional port for adding additive via a syringe as needed to treat the fat cells such as growth factors. Furthermore, the collection canister has an open/close valve for draining and withdrawing fat cells into syringes.01-19-2012
20120022499WEARABLE AUTOMATIC INJECTION DEVICE FOR CONTROLLED DELIVERY OF THERAPEUTIC AGENTS - Exemplary embodiments provide wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates, for example, in a single bolus. Exemplary embodiments provide methods for assembling wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates. Exemplary embodiments provide methods for using wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates.01-26-2012
20120022498Retractable Safety Syringe with Non-Loaded Seal - A retractable safety syringe may have a needle, needle holder, syringe body, a shaft seal, and a plunger assembly. A proximal portion of the body and a piston of the plunger may define a vacuum chamber. The plunger assembly may comprise a shaft coupled to a piston. The shaft may have at least one non-engaging portion and at least one engaging portion. The plunger assembly is movable between a storage position and working positions. In the storage position, little or no force is exerted on the shaft seal by the non-engaging portion. In the working positions, the engaging portion is in sealing engagement with the shaft seal to seal the vacuum chamber. Stopper movement of the retractable safety syringe may be reduced or eliminated if the retractable safety syringe is prefilled.01-26-2012
20120059354METHODS OF IMPROVING FLUID DELIVERY - A method of reducing cell damage can include inserting device into a blood vessel, wherein the device includes a hollow shaft, a lumen, a fluid directing portion comprising a U-shaped lateral orifice extending between the exterior and interior surfaces and a corresponding U-shaped diverter adjacent to the U-shaped lateral orifice, wherein the diverter is disposed within the lumen and transverse to the central axis, and decreasing free plasma hemoglobin levels, thereby reducing damage to circulating blood cells or endothelium during dialysis.03-08-2012
20120157966Drive Mechanism for a Drug Delivery Device - A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing (06-21-2012
20110092954Reusable Auto-Injector - An injection device comprises a first sub-assembly comprising a chamber for holding a fluid and a transfer assembly moveably disposed within the chamber. The chamber comprises an exit aperture and an inner surface and the transfer assembly has an outer surface substantially in contact with the inner surface about its perimeter. The transfer assembly is adapted to transfer fluid into the chamber when the transfer assembly is moved within the chamber.04-21-2011
20110092953Flowable Carrier Matrix - A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.04-21-2011
20110092952Shield Apparatuses and Methods For Storing Syringe Assemblies and Needle Assemblies - The present invention is directed to shield apparatuses configured to hold syringe assemblies in a manner that preserves their ease of use and convenience. In some embodiments, the syringe assemblies are detachable, and the shield apparatuses provide for convenient interchanging of the needle assemblies, as well as methods for administering injections to a patient.04-21-2011
20120157965HAZARDOUS AGENT INJECTION SYSTEM - Injection systems comprising a powered injector and one or more hazardous agents are disclosed.06-21-2012
20120209245Process for using a needle having multiple apertures for injections into subcutaneous tissue - The present invention discloses a process for using needle having multiple apertures for insulin injections into subcutaneous tissue, whereby the insulin dispersion pattern is such that insulin is absorbed at an optimal rate even when the needle is inserted too deeply into the muscle layer or when the insulin is injected into lipohypertrophic tissue.08-16-2012
20090012494INTRADERMAL DELIVERY OF BIOLOGICAL AGENTS - The present invention relates to methods for intradermally delivering one or more biologically active agents such as vaccines and therapeutic agents into the dermis layer of the skin of a subject to obtain systemic delivery or an immune response using a microneedle drug delivery device containing the agent to be delivered. The methods employ a microneedle device with a row of hollow microneedles. The microneedles penetrate the skin of the subject and assume an anchored state in which the microneedles are anchored in the skin and project laterally from the device. A pivotal motion is then performed with the device so that the skin in which the microneedles are engaged is lifted above the initial plane of the surface of the skin while the biologically active agent is delivered. The methods of the invention elicit increased humoral and/or cellular response as compared to conventional vaccine delivery routes, facilitating dose sparing.01-08-2009
20120157967SYSTEM AND METHOD FOR MINIMALLY INVASIVE DISEASE THERAPY - A system for treating a lesion site of a patient is disclosed. The system includes a cannula having a lumen, a conduit in communication with said lumen, an introducer stylet removably disposed within said cannula, a resecting device selectively insertable within said cannula, and an adjuvant treatment device selectively insertable within said cannula.06-21-2012
20100137829Injection Gateway - The current invention relates to an injection gateway (06-03-2010
20120157964DEVICE AND METHOD FOR THE DELIVERY OF MEDICINAL LIQUID DIRECTLY FROM A SMALL BOTTLE (VIAL) - A device for the delivery of medicinal liquids, in which the device includes a base configured for sealing attachment to a container pre-filled with liquid medicine and a displaceable actuator element associated with the base. The association is that of a piston and a cylinder such that the base and the displaceable actuator element define between them a pressure generating volume. The base includes a piercing element having at least one air delivery passage providing fluid communication between the pressure generating volume and an interior of the container, the piercing element also includes at least one liquid delivery passage providing fluid communication between the interior of the container and a medicinal delivery element.06-21-2012
20110066135SINUS DELIVERY OF SUSTAINED RELEASE THERAPEUTICS - The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.03-17-2011
20120123385DEVICES, SYSTEMS, AND METHODS FOR MEDICAMENT DELIVERY - An apparatus includes a housing, a medicament container, an actuator, and a biasing member. The actuator is configured to move the medicament container within the housing when the actuator is moved from a first configuration to a second configuration. The actuator includes a gas container and a puncturer. When the actuator is in the first configuration, a portion of the puncturer is disposed apart from the gas container. When the actuator is in the second configuration, the portion of the puncturer is disposed within the gas container. The gas container has a longitudinal axis offset from a longitudinal axis of the medicament container. The biasing member is configured to bias the actuator toward the second configuration.05-17-2012
20100094255CANNULATED SENSING DEVICE - A cannulated sensing device is disclosed and can include a housing that can have a proximal end and a distal end. A cannula can extend from the proximal end of the housing to the distal end of the housing. Further, a sensor can be attached to the distal end of the housing.04-15-2010
20100094253Drive mechanisms suitable for use in drug delivery devices - The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device.04-15-2010
20100094254Formulation Delivery Device - The present invention provides a device for injection of formulations into a patient. In one embodiment the injection is sub-cutaneous. The device is convenient for injecting viscous formulations that would otherwise clog conventional injection devices, for example formulations containing microspheres, suspensions, and other viscous substances. Generally, the device features a needle for piercing the skin, an internal chamber for holding and transmitting fluid, a plunger for applying pressure to the internal chamber, a switch for triggering withdrawal of the needle, a sheath at least partially encompassing the needle and having a flow path within the sheath, and a spring that expands when the switch is triggered, and which thereby at least partially withdraws the needle from the sheath.04-15-2010
20120123387HOLLOW MICRONEEDLE ARRAYS - The present disclosure relates to apparatus, assemblies, combinations, and methods for infusing fluids by hollow microneedles.05-17-2012
20120123386INTRADERMAL INJECTION ADAPTER - An intradermal injection assembly for injecting a medicament into skin could form an intradermal needle with an adapter, an intradermal syringe with an adapter or an adapter for a merger with a syringe with a cannula. The intradermal adapter in these devices has a body having a longitudinal axis, a central portion having a cannula channel and a distal protrusion extending generally parallel to the longitudinal axis. The distal protrusion of the adapter has a first skin contacting surface extending generally parallel to the longitudinal axis. At least a portion of the distal protrusion is generally transparent such that the portion of the cannula that extends distally relative to a demarcation plane can be viewed through the distal protrusion during insertion of the cannula into a patient's skin.05-17-2012
20090131907Endoscopic Cardiac Surgery - Apparatus and surgical methods establish temporary suction attachment to a target site on the surface of a bodily organ for enhancing accurate placement of a surgical instrument maintained in alignment with the suction attachment. A suction port on the distal end of a supporting cannula provides suction attachment to facilitate accurate positioning of a needle for injection penetration of tissue at the target site on the moving surface of a beating heart. Force applied via the suction attachment to the surface of the heart promotes perpendicular orientation of the surface of the myocardium for enhanced accuracy of placement of a surgical instrument thereon. A hollow needle and a supporting channel therefor, each include a slot along an outer wall between ends thereof, are selectably rotatable to align the slots for releasing a cardiac lead from within the needle through the aligned slots.05-21-2009
20120165783DEVICE FOR AT LEAST ONE OF INJECTION OR ASPIRATION - Micro-volume devices, systems, and associated methods that facilitate the injection or aspiration of precisely controlled volumes of materials at precisely controlled rates are provided. In one embodiment, a micro-volume device includes a syringe and a lead screw connected to a plunger of the syringe. A mechanical interface is connected to the lead screw and includes a first set of cams adjacent a proximal portion and a second set of cams adjacent a distal portion. A mechanism is configured to oscillate a structure in a direction parallel to a longitudinal axis of the lead screw such that one or more projections of the structure to alternatively engage cams of the first and second sets of cams in a manner that results in rotation of the mechanical interface in a single direction for highly controlled linear displacement of the plunger.06-28-2012
20110125130RETRACTABLE NEEDLE ASSEMBLY AND SYRINGE UTILIZING THE SAME - An injection device including a barrel, a hollow plunger having a portion structured and arranged to move within the barrel, a needle unit, and a safety system that one of automatically causes the needle unit to retract into the plunger when the plunger reaches a substantially fully depressed position. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.05-26-2011
20120130341COMBINED IV BAG AND PUMP SYSTEM AND METHOD - An intravenous fluid container is disclosed, wherein the fluid container comprises a bag, a fluid reservoir formed within the bag, an outlet, and a pumping element formed within the bag and fluidically coupled between the fluid reservoir and the outlet.05-24-2012
20120130343Tissue penetration device - An agent injection device is provided that is capable of injecting an agent to a known predetermined tissue depth. An injection member has an elongate injection shaft with an outlet port configured to dispense an agent at a controllable time. A controllable driver is coupled to the elongate injection shaft and is configured to drive the injection member into target tissue. A velocity control system is in communication with the controllable driver and is configured to control the velocity of the elongate injection shaft.05-24-2012
20120130346Medicated Module for a Drug Delivery Device - A medicated module (05-24-2012
20120130344Skin Gripping Means, Injector Including the Skin Gripping Means and Method of Performing a Subcutaneous Injection - A skin gripping means for use with an injector (05-24-2012
20120136337HYPODERMIC NEEDLE SYSTEM AND METHOD OF USE TO REDUCE INFECTION - A hypodermic needle system and method for reducing the incidence of infections due to administering fluids by injection to humans or animals is provided. The hypodermic needle system may include a needle with an insert disposed within its hollow channel to substantially prevent bacteria, fungi and/or other organisms/contaminants, which may be present on the exterior surface to be penetrated, from adhering to the inner surfaces of the needle's channel or become trapped in the needle bore. The hypodermic needle system may include a film that covers at least one surface of the needle or insert, and/or have a bent or curved tip to reduce the ability of infectious agents to adhere to said surface/space within the needle. Additionally, the hypodermic needle system may include an anti-infection agent, such as an antibiotic or antiseptic to further reduce the incidence of infections, and may include an attachment member which reduces the risk of infection.05-31-2012
20110184381REPAIR OF DEFECTS OR LESIONS IN CARTILAGE AND BONE USING A CHONDRO-REGULATIVE MATRIX - Methods and compositions are provided for the treatment and repair of defect in the cartilage in partial- or full-thickness defects in joints of animals, in particular humans. To induce cartilage formation, a defect in cartilage is filled with layers of thin flaps of synovium or of peritendineum, which contains chondro- and osteo-progenitor cells, with interposed layers of a matrix. The matrix contains a chondrogenic factor, which induces chondrogenesis of chondroprogenitor cells in the flaps, and an anti-hypertrophic agent, which arrest differentiation of chondrocytes in an early phase, in an appropriate delivery system. The matrix filling the bone area of a full-thickness defect may contain an osteogenic factor, which induces osteogenesis of osteoprogenitor cells. The layer of a flap between cartilage and bone areas may work as a barrier, which prevents blood vessels and associated cells from penetrating from the bone area into the cartilage area. To promote the induction of chondro- and osteo-genesis of the progenitor cells in the flaps of synovium or peritendineum effectively, the flaps may be treated with enzymes, e.g., matrix metalloproteinases or be punched by a needle before filling a defect.07-28-2011
20110184383SYRINGE PUMP - A syringe pump includes: a syringe mounting part on which to mount a syringe outer cylinder of a syringe; a clamp which is pulled downward by an elastic member, contacts an upper surface of the mounted syringe outer cylinder and thereby fix the syringe outer cylinder; a slider which holds a plunger flange of a plunger of the mounted syringe by levers and which pushes out the plunger; and a display or monitor of which the display is controlled by the computer. Regarding an operation of mounting the syringe outer cylinder onto the syringe mounting part, an operation of setting the plunger flange into the slider, and an operation of fixing the syringe outer cylinder with the clamp, the display or monitor alternately displays the respective states before and after the operations at a predetermined interval.07-28-2011
20110184382MULTI-PURPOSE ARTICLES FOR SANITIZING AND CAPPING LUER ACCESS VALVES - Multi-purpose devices for capping fluid reservoirs and sanitizing accessible surfaces of fluid-transporting medical fittings (e.g., luer access valves) at risk of contamination with infectious agents are described, as are methods for making and using such devices.07-28-2011
20120083762METHOD OF DELIVERING MATERIAL OR STIMULUS TO A BIOLOGICAL SUBJECT - A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. A spacing between projections is also at least partially determined based on an arrangement of the targets within the body.04-05-2012
20100174268METHODS OF VENTING, SEALING, AND DISPENSING FROM A MEDICAMENT CONTAINER - A sealing assembly movable within an opening of a medicament container allows (1) gases to be vented from the container, (2) medication to be stored in the container, and (3) medication to be dispensed from the container. Methods of limiting exposure of the medication to oxygen to prevent degradation of the medication while in the medicament container are also disclosed.07-08-2010
20120172835Multi-Conduit Balloon Catheter - A suctioning and irrigating sinus balloon catheter is provided for treating a patient's paranasal sinus system, including dilating prepared openings, and natural ostia and ducts and excising sinus cavities and choana. The catheter has a number of fluid carrying conduits to provide irrigation, suction and inflation/deflation to the distally mounted balloon. The catheters have sufficient stiffness and column strength that the balloon carrying distal segment of the catheter can be pushed into the prepared opening, natural ostium or duct, choana or sinus to be excised. Some catheters can be hand bendable by the surgeon. Some catheters provide the capability of threading an endoscope through one of the conduits. The methods use the balloon catheters to dilate prepared openings to selected parts of the sinus system, to dilate natural ostia and ducts of the sinus system, choana, and/or to dilate sinus cavities to remove them.07-05-2012
20110202034MODULAR MEDICAL FLUID HEATING APPARATUS - A controller and a plurality of concatenated heating modules in electrical communication with the controller. The controller controls the flow of current to the plurality of heating modules in response to temperature measurements from at least one of the plurality of heating modules. In one embodiment, each of the plurality of heating modules concatenated with another heating module is connected by Luer-Lok™ connectors. In another embodiment, the modular medical fluid heating system further includes an auxiliary heating unit in electrical communication with the controller and in physical juxtaposition with the plurality of heating modules. The invention also relates to a heating module for a modular medical fluid heating system including a fluid input port; a fluid output port; and serpentine tubing through which fluid passes from the fluid input port to the fluid output port. In one embodiment, the heating module can be concatenated with other heating modules.08-18-2011
20120220981Transcutaneous Multimodal Delivery System (TMDS) - A transcutaneous multimodal delivery device for drug delivery and the methods of making and using the same are provided.08-30-2012
20120220980Transdermal Patch Containing Microneedles - A transdermal patch that can easily deliver a controlled volume of a fluidic drug compound to the skin is provided. More particularly, the patch contains a microneedle assembly that is configured to be placed in fluid communication with a drug delivery assembly. The microneedle assembly contains a support and a plurality of microneedles that extend outwardly from the support. The microneedles are formed with one or more channels of a certain dimension such that passive capillary flow drives the flow of the drug compound. The drug delivery system contains a reservoir for the drug compound that is in fluid communication with a rate control membrane that helps control the flow rate of the drug compound by modulating its pressure downstream from the reservoir. A release member is also positioned adjacent to the microneedle and drug delivery assemblies. Prior to use, the release member acts as a barrier to the flow of the drug compound and thus inhibits premature leakage. In this manner, the patch can initially be provided in an “inactive” configuration in which the drug compound is securely retained. When it is desired to release the drug compound, the patch can simply be activated by at least partially separating the release member from the drug delivery and microneedle assemblies.08-30-2012
20100298809Method of Using Prefilled, Single Dose, One Time Use Self-Destructing, Auto-Disabling Safety Syringe - The present invention relates to the method of use for a single dose, single use, self-destructing, auto-disabling safety syringe. The invention successfully addresses and solves the problems of the prior art by combining the use of COC injection molding with the advantages presented by the ampoule cartridge and the traditional safety syringe all integrated into a single device. A pre-filled ampoule or barrel is molded with minimal draft enabling the syringe's piston plunger to be partially self-lubricated by the syringe's contents. The addition of an internal auto disabling coupler to the piston plunger allows the device to be used only a single time. In addition, the present invention's structure is such that its safety sleeve necessarily moves forward to cover the syringe's needle after use. The invention's elements solve the biocompatibility and safety problems of the prior art and provide an exact dose, prefilled, single use, safety syringe.11-25-2010
20120179137Compact Device That Rapidly Mixing and Deliverings Substances To a Patient - Injection devices are disclosed for injections of substances. The disclosed devices separately may hold two separate substances, e.g., solid, liquid or gas substances, in separate compartments which are interrupted so that the separate substances come into contact during the activation of the device. One disclosed device includes a needle for injection and two substances that are mixed with only a few actions by the operator of the device. The device may or may not activate mixing by the removal of a sleeve which triggers compartment interaction through movement of pins, pegs, springs, wires, string, or other mechanisms which allow the materials held in separate chambers to come into contact with each other. Operator error during mixing and checking the dosage of substances to be injected is avoided with the disclosed devices. Also, the needle is maintained in a sterile state because the needle is held internally of the device until the sleeve is removed and the device begins to activate.07-12-2012
20120259312METHODS AND DEVICES FOR BONE PREPARATION - A manifold has at least one manifold aperture extending therethrough and selectively placed in fluid communication with a fluid source. An insertion structure has at least one interior cavity at least partially defined by a structure shell and is selectively placed in fluid communication with a corresponding manifold aperture. The insertion structure is configured for selective placement in a penetrating relationship with a patient tissue below a surface of the patient tissue. At least one shell perforation extends through the structure shell and places the interior cavity in fluid communication with a surrounding ambient space. At least one fluid path extends from the fluid source, through the manifold aperture, into the interior cavity, through at least one shell perforation, and at least one of a proximate relationship and a contacting relationship with the patient tissue beneath the outer surface thereof. A fluid is directed along the fluid path.10-11-2012
20100274222METHODS AND DEVICES FOR PARANASAL SINUS DRUG DELIVERY - Described herein are methods and devices for delivering a drug to the frontal sinus system. An inflatable implant is positioned within the frontal sinus system using an anchoring means secured within the frontal sinus cavity. A drug-containing fluid is released directly into the frontal sinus drainage system.10-28-2010
20100010468Retrobulbar Needle and Methods of Use - A syringe and needle assembly includes a needle that extends through the barrel of the syringe and is attached to a proximal portion of the syringe. The distal end of the needle extends through a sleeve attached to the distal end of the syringe. The proximal end of the needle includes a spring which biases the needle proximally, so that the distal tip of the needle is normally retracted within the sleeve. The assembly can be used for injections in portions of a patient's body including delicate tissues that could be damaged if contacted by the needle tip01-14-2010
20120253317ADIPOSE TISSUE MANAGEMENT SYSTEMS - The utilization of stored fat cells is provided. Fat cells removed from a patient may be subdivided into a number of fat cell subdivisions for utilization in a series of medical procedures. The fat cell subdivisions can be prepared for short term storage for use in medical procedures to be performed within a defined period time or long term storage for use in one or more medical procedures to be performed in the future. Medical practitioners can utilize stored fat cell subdivisions in a series of procedures on a patient.10-04-2012
20120253315INJECTION NEEDLE FOR FRACTURES - A cannula having proximal and distal ends defines a hollow body. A tissue-piercing tip is formed at the distal end of the cannula and is fluidically sealed from the hollow body. At least one opening is formed in a sidewall of the cannula and fluidically coupled to the hollow body. A fracture may be treated by advancing the tip through soft tissue so that the at least one opening is at least partially disposed within or adjacent to the fracture. The needle is oriented so that the at least one opening faces an exposed end of fracture or within the plane of the fracture line. Then, a therapeutic composition, such as a bone growth factor, is pressured through the hollow body to exit from the at least one opening.10-04-2012
20120253314PALM-CONTROLLED INJECTORS - A palm-controlled device is disclosed for injection of a substance into an organism. The device includes a palm-receiving surface for receiving a palm of a hand, the palm receiving surface being shaped so that the palm is substantially parallel to a surface of an injection site of the organism while operating the device. The palm receiving surface can also be shaped so that the palm is substantially perpendicular to a surface of the injection site. The device also includes an injector having at least one pre-filled syringe, the palm-receiving surface being cooperative with the injector such that when pressure is applied to the palm-receiving surface, the injector is actuated so as to inject contents of the at least one pre-filled syringe. Actuation of the injector is by gradual pressure; not sudden motion. Single or multiple doses of same or different medications can be included in a single injector.10-04-2012
20100268189SYRINGE SYSTEM FOR CONTROLLED DELIVERY OR REMOVAL OF MATERIAL - Embodiments disclosed herein relate to syringe systems for delivering and removing materials, instrument kits that include the syringe systems provided herein, and methods of using the syringe systems and kits provided herein.10-21-2010
20090036869CANNULA SYSTEM - The present disclosure provides a cannula useful for introducing a thermally responsive polymer in situ. In embodiments, the cannula possesses more than one cannula, with the thermally responsive polymer introduced in one cannula, and a material such as a coolant in a second cannula which prevents premature gelling of the thermally responsive polymer.02-05-2009
20120259311FAT REMOVAL DEVICE AND OBESITY TREATMENT - A method for treatment for obesity comprising a medical device attached or implanted in patient's target body organs, wherein in each one of the device attachments, or daily in the case of long continuous attachment, the device removes up to 100 grams of energy containing materials from the body. The medical device optionally contains needles or alternatively contains crawling worm like arm. The energy containing materials may be fat cells, fatty acid molecules driven out from the fat cells or lipids or carbohydrates molecules such as glucose from the blood stream.10-11-2012
20120259313APPARATUS AND METHODS FOR LIMITING PRESSURE AND FLOW WITHIN A MEDICAL INJECTOR - A medical injector (10-11-2012
20090018522TISSUE MODIFICATION BY TARGETED DELIVERY OF HEAT - A method for manipulating a tissue by targeted delivery of heat by heating a liquid contained in an injecting means to a predetermined temperature level and injecting a predetermined volume of said heated liquid into a predetermined depth of the tissue through a needle attached to the injecting means, to thereby manipulate the tissue in the injected area. An apparatus adapted for manipulating a tissue by targeted delivery of heat having a heating means adapted to heat a liquid contained in an injecting means to a predetermined temperature level; an injecting means adapted to contain liquid to be injected said tissue and to inject a predetermined volume of said liquid into a predetermined depth of the tissue through a needle; a temperature sensor adapted to identify the temperature level of the liquid contained in the injecting means and to produce a signal indicating said temperature level; a controller adapted to monitor the sensor signal and to activate or deactivate said heating means and an electromechanical element according to the temperature sensed, and an electromechanical element either integrated or non-integrated to the apparatus that is adapted to allow the injection of the heated liquid.01-15-2009
20090018524EXPANDABLE DELIVERY DEVICE - An expandable drug delivery device that can be implanted or otherwise delivered in and/or adjacent to a bone and/or soft tissue (e.g., connective tissue) for orthopedic applications is disclosed. Devices and methods are described herein for delivering agents for orthopedic and other uses. In particular such devices and methods can be useful for delivering agents to heal damaged tissue or prior to more invasive and traumatic orthopedic procedures.01-15-2009
20090018523DEVICES, SYSTEMS AND METHODS FOR TREATING BENIGN PROSTATIC HYPERPLASIA AND OTHER CONDITIONS - Devices, systems and methods for compressing, cutting, incising, reconfiguring, remodeling, attaching, repositioning, supporting, dislocating or altering the composition of tissues or anatomical structures to alter their positional or force relationship to other tissues or anatomical structures. In some applications, the invention may be used to used to improve patency or fluid flow through a body lumen or cavity (e.g., to limit constriction of the urethra by an enlarged prostate gland).01-15-2009
20120232523DEVICES FOR DELIVERING SUBSTANCES THROUGH AN EXTRA-ANATOMIC OPENING CREATED IN AN AIRWAY - Devices and methods for delivering substances to lung tissue through an extra-anatomic passage created in an airway.09-13-2012
20120232522METHODS AND DEVICES FOR DRUG DELIVERY TO OCULAR TISSUE USING MICRONEEDLE - Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.09-13-2012
20080312635Chemical Applicator - The present invention relates to a device and method for a chemical applicator used applying chemicals to Irving organism's internal tissue, including the internal tissue of plants and animals, for organisms which reside in mediums such as land, air or water. The device of the present invention is predicated, in part, on the piercing elements being engageable with the chemical reservoir in order to effect the coating of the piercing elements with the chemical. Once coated, these piercing elements are then used to pierce the living organism's tissue such as plant tissue to deliver the chemical.12-18-2008
20110004191DOSING MECHANISM FOR A DRUG DELIVER DEVICE - A maximum settable dose feature is disclosed that is set by a user or health care professional one time that prevents future injections from exceeding the desired maximum dose. The feature includes a locking band initially in an unlocked configuration, which transforms to a locked configuration when activated after setting a desired maximum dose. The feature can include a trigger mechanism to transform the locking band to the locked configuration.01-06-2011
20120265167BIOCOMPATIBLE MATERIAL FOR ORTHOPEDIC USES - Biocompatible material for bone repair, especially vertebral bone repair, preferably has three components. The first component is silicon nitride ceramic spheres or shells that can be polyhedral in shape. When grouped together, these ceramic spheres or shells form tessellates having a similar degree of stiffness, strain and stress resistance to cancellous bone. The second component comprises various bioactive factors that are preferably osteoconductive, osteoinductive and osteogenic. The third component is a liquid or gel that combines with the first and second components to form a composite.10-18-2012
20120323216NEEDLESHIELD ASSEMBLY - A needleshield assembly including a needle hub, hypodermic needle and protective cover is disclosed in which the protective cover can both secure and disable the needle following use.12-20-2012
20120271275MEDICAL DEVICES AND METHODS COMPRISING AN ANABOLIC AGENT FOR WOUND HEALING - Improved medical devices and methods are provided comprising an anabolic agent for wound healing. These improved medical devices and methods can enhance wound healing in wounds from cuts, abrasions, lesions, burns including sunburn, surgical incisions, pressure ulcers, diabetic ulcers, traumatic wounds, or other injuries or maladies, which can be chronic or non-chronic in origin. In some embodiments, the medical device comprises a drug depot that releases the anabolic agent over at least 3 days to enhance wound healing.10-25-2012
20120271276SAFETY ASSEMBLY FOR A SYRINGE - A safety support device for a syringe comprises a support sheath for the body of the syringe and an inner sheath suitable for sliding relative to the support sheath between a waiting, retracted position and the extended position for protecting the needle of the syringe. The device has means for holding the syringe body relative to the support sheath and retaining means suitable for being activated to retain g the inner sheath in the waiting, retracted position inside the support sheath and for being deactivated by the piston of the syringe to allow the inner sheath to extend into its protective, extended position.10-25-2012
20120323219DELIVERING DRUGS TO DESIRED LOCATIONS WITHIN A MAMMAL - This document provides materials and methods related to delivering drugs to desired locations within a mammal. For example, materials and methods for implanting a guide wire and a drug eluting implant into a mammal are provided.12-20-2012
20120323218DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of an implantable electrolytic pump include an electrolysis chamber, a drug chamber and an osmosis chamber, the osmosis chamber having a first portion in contact with the drug chamber and a second portion exposed to facilitate contact with a surrounding fluid. The pump further includes a cannula for conducting liquid from the drug chamber and electrolysis electrodes within the electrolysis chamber for causing generation of a gas therein, the electrolysis and drug chambers being in contact such that gas electrolysis within electrolysis chamber forces fluid from the drug chamber into the cannula, contact between the drug chamber and the osmosis chamber permitting fluid admitted into the osmotic chamber from the surrounding fluid to offset volume loss from the drug chamber and prevent buildup of vacuum pressure thereon.12-20-2012
20120323217Cranial Evacuation System and Use Thereof - The present invention relates to a method and device for removing solid matter from a brain and controlling bleeding associated with the removal of the matter. The method involves securing a cranial anchor to a region of the skull in which an opening has been created to expose brain matter and introducing through a passage defined by the anchor a channel member that displaces brain tissue and exposes the solid matter. After removing the solid matter, a flowable hemostat is introduced into the cavity created by removal of the matter. A balloon introduced into the working channel is then inflated to compress the hemostat against the wall of the cavity to control bleeding from blood vessels around the cavity. The device includes a cranial anchor, a channel member defining a working channel, an optional removable trocar, and a catheter for introducing the hemostat and the inflatable balloon into the cavity.12-20-2012
20110238036SUSTAINED RELEASE DELIVERY DEVICES - An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as “coatings,” “skins,” or “outer layers”). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles.09-29-2011
20100234828Methods and Compositions for Facilitating Arterial Access - Provided are methods and compositions for locally increasing arterial diameter and providing local anesthesia in a subject. The methods include applying to a skin site of the subject a topical composition that includes a vasodilation agent and an anesthetic agent in a manner sufficient for locally increasing arterial diameter and providing local anesthesia in the subject. In some embodiments, the method includes inserting a cannula into an artery at the skin site of the subject. Also provided are topical compositions that find use in performing the subject methods.09-16-2010
20120089119SYSTEM AND METHOD FOR AN INJECTION USING A SYRINGE NEEDLE - An auto-injector for injecting a fluid medicament into a patient from a pre-filled syringe requires a disposable cassette that is selectively engageable with the reusable injector. The syringe is latched onto the cassette, and the cassette is then engaged with the injector. Activation of the injector causes a first motor to move the syringe so its needle is extended from a concealed position inside the cassette for injection of the medicament. A second motor on the injector is then activated to expel fluid medicament from the syringe. Then, the first motor is again activated to withdraw the syringe into the cassette for disposal of the cassette/syringe after an injection.04-12-2012
20120089118DELIVERY OF BISPHOSPHONATES BY MICROINJECTION SYSTEMS - A system for the administration of a bisphosphonate to a subject comprises a bisphosphonate formulation and a microinjection device. In an embodiment, the bisphosphonate formulation includes ibandronate sodium. In some cases, the bisphosphonate formulation includes an excipient. The bisphosphonate formulation may be delivered to the subject subcutaneously, transdermally or intradermally.04-12-2012
20120089117APPARATUS THAT INCLUDES NANO-SIZED PROJECTIONS AND A METHOD FOR MANUFACTURE THEREOF - An apparatus that includes a nano-projection array and an application unit configured to displace the nano-projection array to thereby deliver a composition (e.g., vaccine) to a controlled depth within the skin. The nano-projection array includes nano-projections carried by a carrier substrate. The application unit includes a peripheral structure and a displaceable carrier. The nano-projection array can be disposed within the peripheral structure. Displacement of the displaceable carrier causes a corresponding displacement to the nano-projection array. The displacement of the displaceable carrier can be controlled. For instance the distance of displacement of the displaceable carrier can be controlled. A method or process for manufacturing the apparatus is also provided.04-12-2012
20120089116DEVICES FOR DELIVERING SUBSTANCES THROUGH AN EXTRA-ANATOMIC OPENING CREATED IN AN AIRWAY - Devices and methods for delivering substances to lung tissue through an extra-anatomic passage created in an airway.04-12-2012
20120095440INJECTION PORT SYSTEM FOR INTRA-MARROW INJECTION/INFUSION - An injection port system for placement in or on an individual includes a first port (04-19-2012
20120095439IMPLANTABLE THERAPEUTIC DEVICE - A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.04-19-2012
20120095438MEDICATION DELIVERY DEVICE WITH FOLDABLE FINGER PAD - A medication delivery device is configured to deliver medication when a button element is moved, the medication delivery device having a folding finger pad.04-19-2012
20120330275Syringe Evacuator - A syringe evacuator configured to discharge a syringe at a controllable rate. In one embodiment, the syringe evacuator includes a threaded shaft and a syringe depressor platform threaded onto the threaded shaft. The syringe evacuator also includes a spiral spring coupled to the threaded shaft configured to rotate the threaded shaft.12-27-2012
20110295229In-plane electromagnetic mems pump - A micromechanical pumping system is formed on a substrate surface. The pumping system uses a pumping element which pumps a fluid through valves which move in a plane substantially parallel to the substrate surface. An electromagnetic actuating mechanism may also be fabricated on the surface of the substrate. Magnetic flux produced by a coil around a permeable core may be coupled to a permeable member affixed to a pumping element. The permeable member and pumping element may be configured to move in a plane parallel to the substrate. The electromagnetic actuating mechanism gives the pumping system a large throw and substantial force, such that the fluid pumped by the pumping system may be pumped through a transdermal cannula to deliver a therapeutic substance to the tissue underlying the skin of a patient.12-01-2011
20110319865MICRONEEDLE ROLLER (MNR) INFUSION SYSTEM - A micro-needle roller (MNR) infusion system for transdermal delivery of active agents, skin-care products, and other topical formulations is described herein. The infusion system of the instant invention comprises a needle roller assembly with 0.25 mm needles enclosed in a housing with a vacuum line and a disposable cartridge having the active agent, the skin-care product or the topical formulation. The vacuum delivers the fluid and ensures that the skin is being pulled against the needle wheel surface to ensure that penetration of the needles is complete into the skin, simultaneously the fluid is flowing to the wheel and to skin as it rolls along with the outer housing of the tip cap assembly being occluded to the skin surface.12-29-2011
20110319864INJECTOR FOR AUTO-INJECTION OF MEDICATION AND ASSOCIATED METHOD OF USE - A key-shaped portable injector for delivering a dose of medication, the injector preferably including a cap, a body having an internal cavity, a syringe or cartridge with an attached needle within the internal cavity, a protective sleeve, an activation mechanism and a safety mechanism wherein the injector is reconfigurable from a first, non-deployed configuration where the activation mechanism, syringe or cartridge and a safety mechanism are all in a first position with respect to the body to a second, deployed configuration where the safety mechanism, activation mechanism, and syringe or cartridge are all in a second position with respect to the body and to a third, depleted configuration where the activation mechanism is back to its first position and a protective sleeve is in its second position.12-29-2011
20120101475High Efficiency Auto-Injector - An auto-injector apparatus and associated methods utilizing specific dimensions and parameters of use for the auto-injector are provided for achieving increased effectiveness of the auto-injector device in delivering medicament into the patient's body, and in dispersion of the medicament from the initial injection site into the surrounding bodily tissues.04-26-2012
20120289929Drive Mechanisms Suitable for Use in Drug Delivery Devices - The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device.11-15-2012
20120289931MEDICAMENT KIT AND METHOD OF USE - A medicament delivery system and method of use. A medicament delivery system comprising a medicament, a medicament delivery device, an alerting device, operating instructions, and a carrying case. The medicament can be glucagon for use with Type 1 diabetics. A method where a person assisting a patient in medical distress locates the patient's medicament injection pen by using an alerting device that sends a signal to the pen's carrying case, and where a triggered alarm in the case alerts the assisting person of the pen's whereabouts. A method where a person assisting a patient in medical distress provides a medicament to the patient by pushing an actuator on a medicament injection pen until a diaphragm separating two chambers in the pen breaks allowing medicament and diluting solution to mix, and where the assisting person then injects the mixture into a soft tissue of the patient.11-15-2012
20120289930AUTOMATIC-LOCKING SAFETY NEEDLE COVERS AND METHODS OF USE AND MANUFACTURE - A single-use needle cover configured to obscure, protect, or hide at least a portion of a needle from view before, during, and/or after an injection and/or aspiration procedure is disclosed. In some embodiments, the cover includes a housing at least partially containing the needle and configured to couple to a syringe, wherein the housing includes an axis and a guide member. In some embodiments, a sleeve has a plurality of tracks configured to slidingly receive the guide member, wherein the sleeve is configured to retract, extend, and rotate with respect to the housing. In some embodiments, after the sleeve has been retracted and extended one time, a first locking member inhibits further retraction of the sleeve and a second locking member inhibits rotation of the sleeve.11-15-2012
20100185178INJECTION DEVICE - An injection device including a syringe having a needle, a barrel and a plunger. The device is configured to provide an automatic injection cycle and includes a drive coupling arrangement between a driving spring and the syringe. In operation, a drive force can be selectively transmitted between the respective first and second parts of the drive coupling arrangement depending upon their relative rotational positions such that, when the first and second parts are in a first relative rotational position during the dispensing stage, a driving force is transmitted to the plunger to drive the plunger into the barrel, and, when the first and second parts are in a second relative rotational position during the retraction stage, no force is transmitted to the plunger to allow the plunger and the syringe to retract.07-22-2010
20100185177HANDS-FREE INTRAMUSCULAR INJECTION DEVICE - An injection device for hands-free, transdermal injection of a liquid medicament, configured for easy handling and for manipulation by the use of the hand or fingers of the medical technician The device includes a housing having a base for attachment of the housing to the skin of a patient, an injection needle, and a reservoir for containing a vaccine. The device also has a means for expressing the vaccine from the reservoir through the injection needle that includes a mechanical force means for storing potential energy and exerting a mechanical force, and a hydraulic force means for transmitting the mechanical force into a hydraulic force. The hydraulic force is exerted onto the vaccine in the reservoir, thereby pressurizing and passing the vaccine through the injection needle. The mechanical force means is typically a mechanical spring, and the hydraulic force means is typically a closed hydraulic circuit.07-22-2010
20130012919RETROBULBAR SYRINGE AND METHODS OF USE - A device useful for making retrobulbar injections includes an inner syringe contained within an outer syringe. A spring retained within the outer syringe biases the inner syringe proximally, which a catch mechanism on the two syringes prevents the inner syringe from moving out of the outer syringe. A distal needle on the inner syringe is movable within a distal sheath of the outer syringe, and can be extended beyond the distal end of the sheath to permit the device to piece more resilient tissues, and can be withdrawn by action of the spring within the sheath to protect more delicate tissues from the needle.01-10-2013
20120150146Syringe Devices, Components of Syringe Devices, and Methods of Forming Components and Syringe Devices - A syringe device includes a syringe barrel and piston having a fluid passageway extending from a vial port. Another syringe device includes a syringe barrel, a piston sleeve and an insert. A channel extends along a side of the insert. A valve controls fluid communication between the channel and the syringe barrel. Another syringe device has a syringe barrel, a piston sleeve and an insert. A valve controls fluid communication between a compartment within the insert and the syringe barrel. A method of preparing a medication includes providing a component within a syringe barrel and another component within a compartment of a piston insert. A seal is over-molded onto a tip of the insert and an end of a piston sleeve. The sleeve is rotated relative to the insert to establish fluid communication between the compartment and the barrel chamber.06-14-2012
20120150145METHODS OF TISSUE SAMPLING, COLLECTION, PROCESSING AND RE-INJECTION USING MODULAR, DISPOSABLE TISSUE ASPIRATION, PROCESSING, COLLECTION AND/OR RE-INJECTION COMPONENTS - Methods of tissue sampling, collection, in situ processing and re-injection using modular, disposable tissue aspiration, processing, collection and/or re-injection components.06-14-2012
20130018357MEDICATION RESERVOIR - A method and apparatus for a connection interface between a reservoir or syringe, infusion set tubing, and an infusion pump is provided. A base is provided which is adapted to receive a reservoir. The base has a base engagement member, such as a detent, projecting therefrom. A cap is provided which is adapted to receive the base. The cap includes a first cap engagement member, such as a detent opening, which is adapted to removably engage the base detent. The cap further includes a second cap detent opening which is adapted to removably engage the base detent. A piercing member, such as a needle, is disposed in the interior of the cap in such a manner that the needle is separated from the reservoir septum when the base detent is in the first cap detent opening, and the needle pierces the reservoir septum when the base detent is in the second cap detent opening. When the reservoir, the base and the cap are connected to form an integrated unit, this unit is then capable of being inserted and secured in the infusion pump housing.01-17-2013
20130018356CHARACTERIZING MEDICATION CONTAINER PREPARATION, USE, AND DISPOSAL WITHIN A CLINICAL WORKFLOW - Data characterizing a medication container (e.g., an identifier, etc.) is received from a manually administrable medication device within a clinical workflow. Thereafter, one or more data records are generated, modified, or appended to include a portion of the received data. Subsequent requests that include the medication source from remote sources are answered by transmitting data stored in the one or more data records. Related apparatus, systems, methods, and articles are also described.01-17-2013
20110160697DEVICE AND METHOD FOR ENHANCED SUBCUTANEOUS INSULIN ABSORPTION - Products and methods directed to the improved infusion of fluids are disclosed. Such products and methods can be used to more efficiently and efficaciously administer therapeutic pharmaceuticals to a subject in need of treatment. In many instances, the systems comprise a therapeutic fluid delivery system and a mechanism for enhancing the absorption of the therapeutic fluid. The enhancement of the absorption of the therapeutic fluid is generally performed locally i.e., at or near the site of administration of the therapeutic fluid. The system and methods can be used to deliver any number of therapeutic fluids including but not limited to insulin.06-30-2011
20110160696INJECTION PORT DEVICE ADAPTED FOR USE WITH INSULIN PUMP - An injection port comprises a body having an outlet delivery cannula configured to pierce subcutaneous tissue of a patient to deliver medication. The port includes multiple injection sites, each of which can be used multiple times, and each of which is sealed. Each injection port is configured to temporarily receive a delivery device and reseal itself when the delivery device is removed. In one embodiment, a seal includes a pierceable stationary septum that reseals itself when a sharp cannula is removed. One injection site also includes locking features to receive a locking device of a delivery device and temporarily lock the delivery device in place at the injection site. The locking device may later be unlocked when delivery is complete and removed. In one application, a diabetic may use one injection site for syringes during the day and the locking injection site for a insulin pump during sleeping hours.06-30-2011
20080255537BIOCOMPATIBLE NANOPARTICLE COMPOSITIONS AND METHODS - Various compositions, methods, and devices are provided that use fluorescent nanoparticles, which can function as markers, indicators, and light sources. The fluorescent nanoparticles can be formed from a fluorophore core surrounded by a biocompatible shell, such as a silica shell. In one embodiment, the fluorescent nanoparticles can be delivered to tissue to mark the tissue, enable identification and location of the tissue, and/or illuminate an area surrounding the tissue. In another embodiment, the fluorescent nanoparticles can be used on a device or implant to locate the device or implant in the body, indicate an orientation of the device or implant, and/or illuminate an area surrounding the device or implant. The fluorescent nanoparticles can also be used to provide a therapeutic effect.10-16-2008
20080249501Methods for Simultaneous Injection and Aspiration of Fluids During a Medical Procedure - Methods for simultaneous injection and aspiration of fluids during a medical procedure are disclosed. Embodiments include methods for operating medical devices within the subarachnoid space of the spinal column to gain access to the ventricles of the brain, as well as the surrounding cranial subarachnoid space. A dual lumen constant volume aspiration catheter is disclosed that injects a volume of injectable fluid to break up an obstruction within the brain or cranial subarachnoid space while simultaneously aspirating a same volume of aspirated fluid from the treatment site. Methods hereof include constant volume re-circulation of cerebral spinal fluid to and from a treatment area within one of the brain and the surrounding cranial subarachnoid space, which may be desirable during a ventriculostomy.10-09-2008
20080249500APPARATUS AND METHOD FOR TREATMENT OF ETHMOIDS - A method of treating diseased ethmoid sinuses in a patient with a therapeutic agent includes providing an injection device comprising an elongate member having a proximal end, a distal tip or end, and a lumen extending between the distal tip and the proximal end, the proximal end being operatively coupled to a source of the therapeutic agent. The distal tip of the injection device is inserted at least partially within an interior portion of an ethmoid air cell. The therapeutic agent is then injected into the interior portion of the ethmoid air cell using the injection device, the therapeutic agent being delivered via the lumen in the elongate member.10-09-2008
20080243101ABSORBABLE POLYMER FORMULATIONS - A co-polyester which includes the reaction product of a polycondensation polyester and epsilon-caprolactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and a diol. The co-polyester is injectable and absorbable into animal, such as human, tissue and can be used for facial cosmetic or reconstructive surgery of soft tissue. Another embodiment is directed to a method for preventing adhesion using a co-polyester comprising the reaction product of a polycondensation polyester and epsilon-caprolactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and a diol, and the co-polyester comprises about 40 to 50% by weight of the polycondensation polyester based on the total weight of the co-polyester.10-02-2008
20080234656METHOD FOR ALTERING DRUG PHARMACOKINETICS BASED ON MEDICAL DELIVERY PLATFORM - A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm.09-25-2008
20080228164Implant delivery system - An embodiment includes a site marker deployment system that includes a deployment device having an inner cannula and a site marker that may be selectively interposed within the inner cannula. The site marker includes at least one generally elongated filament member. The filament member is selectively configurable between a first configuration, where the site marker can not be interposed within the inner cannula, and a second configuration, where the site marker may be interposed within the inner cannula. A portion of the site marker is elastically deformed when the site marker is interposed within the inner cannula. The site marker deployment system also includes a restraining member selectively interposed within the inner cannula and selectively engaging the site marker such that a force exerted on the restraining member may urge the site marker at least partially into the inner cannula.09-18-2008
20130178827COMPOSITIONS AND METHODS FOR TREATING JOINTS - Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluraonic acid (“HA”), in combination with a lyophilized second component that is effective to at least temporarily reduce the viscosity of the HA. In an exemplary embodiment, the second component is one or more glycosaminoglycans (“GAG”), such as chondroitin sulfate (“CS”), including CS4 and/or CS6, dermatan sulfate, heparin, heparan sulfate, and keratan sulfate. The composition can optionally include other joint supplements, such as glucosamine (“GlcN”)07-11-2013
20080221549RAPID INJECTION DEVICE - A rapid injection device including a hand-held injection unit having multiple needles to inject at least one subject, and an injection manager to control at least the injection unit according to injection parameters, such as for performing rapid injections by receiving a mode of operation, receiving a dosage amount, receiving a needle extension length, extending a needle the length of the needle extension length out a needle storage unit, and pumping the dosage amount of fluid through the needle.09-11-2008
20080221548Eradication of Pigmentation and Scar Tissue - The invention is a non-surgical method for the eradication of pigmentation and scar tissue from an area of skin. The method comprises repeatedly puncturing the area of skin with an array of needles. As the needles are inserted into the skin, the needles and surface of the skin are washed with a clean solution. As the needles are withdrawn from the skin, the flow of clean solution ceases and the dirty solution, which contains cellular fluids and pigments released by the action of the needles, is removed from the surface. The invention is also a solution, which is used to clean the needles and to aid in destroying the pigment containing cells, and an apparatus, which is especially designed to move the needles into and out of the surface of the skin and to provide synchronization of the motion of the needles and flow of the solution such as to maximize the effectiveness of the method.09-11-2008
20130178822DELIVERY AND EXTRACTION DEVICES - This invention provides a device for delivering substances such as medical implants and tissues. The device comprises a mandrel and a mandrel guide whereby substances are delivered by retracting the mandrel guide relative to the mandrel. Included among the various embodiments are devices specialized for delivering retinal pigment epithelial (RPE) cells or nanoplates containing RPE cells to the retina, devices with precise control of delivery, devices with specialized mandrels and/or nozzles, and multifunctional devices adapted to provide additional functions such as infusion and/or suction, illumination, and diathermy.07-11-2013
20130178830DEVICES FOR TRANSDERMAL DRUG DELIVERY - A transdermal drug delivery device comprises needles or other means for piercing the skin of a patient to form pores in a predefined pattern; and carriers in the same pattern that may be loaded with a drug for delivery. Means are provided for applying the carriers to the pores to deliver the drug through the pores to a location beneath the surface of the skin. The carriers may remain outside the pores, be introduced into the pores after the needles have been removed, or be inserted alongside the needles while they are still in place.07-11-2013
20130178823AUTOMATIC MIXING DEVICE AND DELIVERY SYSTEM - A wet/dry auto-mixing injector having a mixing device containing at least one microfluidic channel for mixing or dissolving a dry component with a wet component stored in the injector device.07-11-2013
20130178824RENAL NERVE DENERVATION VIA THE RENAL PELVIS - Apparatus, systems, and methods provide access to the renal pelvis of a kidney to treat renal nerves embedded in tissue surrounding the renal pelvis. Access to the renal pelvis may be via the urinary tract or via minimally invasive incisions through the abdomen and kidney tissue. Treatment is effected by exchanging energy, typically delivering heat or extracting heat through a wall of the renal pelvis, or by delivering active substances.07-11-2013
20130178825CATHETER-DRESSING SYSTEMS WITH INTEGRATED FLUSHING MECHANISMS - Methods and devices are disclosed herein that generally involve a sterile catheter-dressing system that allows for integrated injection of fluids, e.g., a saline flush, during the process of catheter insertion and sterile dressing placement. Such methods and devices can be used as a fully integrated catheter insertion system, or to convert existing catheter insertion devices and methods into integrated flush and sterile sealing catheter-dressing systems. Such methods and devices can greatly simplify the catheter insertion process, and can allow the reproducible placement of a fully sterile and flushed vascular catheter, as well as the placement of a durably sterile circumferentially sealing and securing dressing.07-11-2013
20130178826ACCURATE FLOW CONTROL IN DRUG PUMP DEVICES - The accuracy of drug delivery with drug pump devices may be improved by a combination of pump operation at high flow resistances and pump pressures, pressure-relief mechanisms, and sensor-based feedback for pump control.07-11-2013
20130178828DEVICE FOR MEDICAL TREATMENT - A medical treatment device enables an injection needle to accurately puncture brain tissue at a prescribed position and a drug solution to be injected into brain tissue, while avoiding damage to the brain tissue as the injection needle is handled. The use of the medical treatment device involves inflating a first balloon located on the outside of a catheter, directing a distal portion of a puncture needle, which is located inside the catheter, to outside the catheter through an opening in the catheter, after which the first balloon is deflated and a second balloon is inflated, and moving the catheter towards the brain tissue located on the opening side so that the injection needle projecting from the opening punctures the brain region.07-11-2013
20130178829METHODS OF TREATING MEDICAL CONDITIONS BY TRANSVASCULAR NEUROMODULATION OF THE AUTONOMIC NERVOUS SYSTEM - The present invention is directed to a method of treating a respiratory or pulmonary condition in a patient by transvascular neuromodulation of an adrenal gland or neural structures that innervate the adrenal gland or components thereof. Methods also include implanting a controller in the patient to control delivery of a therapy signal to the patient's adrenal gland. The therapy signal can be an electrical and/or chemical signal.07-11-2013
20120253316PERCUTANEOUS BIOLOGIC DELIVERY SYSTEM - A bone grafting delivery device, method and kit is provided. The bone grafting material delivery device may include a needle having a cutting edge located at a distal end of the needle. The needle may be configured to be inserted within a bone via an entry point created through the skin of a patient. Additionally, the bone grafting material delivery device may include a plurality of dilators attachable sequentially to the needle using a swivel assembly. The plurality of dilators may be configured to articulate relative to needle in a plurality of directions via the swivel assembly. Furthermore, a final dilator of the plurality of dilators may include an opening at a distal end of the final dilator for depositing bone grafting material onto the bone or in a void.10-04-2012
20090198212Endoscopic injection needle assembly inluding an endoscopic hood - An endoscopic injection needle assembly and method of using the same. According to one embodiment, the assembly includes an endoscope, an injection needle, an endoscopic hood and a suction source. The endoscope is shaped to include a proximal end, a distal end, and a plurality of longitudinal channels. The distal end of the injection needle is positioned within a working channel of the endoscope. The injection needle is sized relative to the working channel to permit fluid to flow around the injection needle in the working channel. The endoscopic hood is mounted on the distal end of the endoscope and extends distally therefrom, the endoscopic hood being in fluid communication with the working channel and having an opening through which fluid may be drawn into the endoscopic hood. The suction source is applied to the proximal end of the working channel to cause fluid to be drawn into the endoscopic hood through the opening and then proximally through the working channel. In addition, suction causes tissue to be drawn into the endoscopic hood. The injection needle may then be operated to penetrate the suctioned tissued.08-06-2009
20110270222Injection Pen For Intradermal Medication Injection - A pen body assembly (11-03-2011
20130172850APPARATUS AND METHOD FOR DISPENSING BONE CEMENT - An apparatus and method for dispensing bone cement includes a cartridge for containing the bone cement. The apparatus also includes a plunger insertable into the cartridge. An impedance sensor is coupled to the plunger and configured to produce an output signal indicative of an impedance of bone cement contained in the cartridge. The apparatus may also include a processing circuit configured to determine an impedance value of bone cement contained within the cartridge based on the sensor signal. The processing circuit may activate a visual indicator based on the impedance value to indicate that the dough time, the end-of-work time, and/or setting-time of bone cement contained in the cartridge has been reached.07-04-2013
20130096534Drug Delivery Systems and Methods - A delivery system includes a housing along with a tip connected to one end of the housing. A first cannula extending from the tip is provided for inserting a rod implant into tissue. A second cannula, concentrically disposed within the first cannula, is utilized to force the rod implant from the first cannula and for ejecting a fluid behind the inserted rod implant in the tissue.04-18-2013
20130096533Tissue penetration device - An agent injection device is provided that is capable of injecting an agent to a known predetermined tissue depth. An injection member has an elongate injection shaft with an outlet port configured to dispense an agent at a controllable time. A controllable driver is coupled to the elongate injection shaft and is configured to drive the injection member into target tissue. A velocity control system is in communication with the controllable driver and is configured to control the velocity of the elongate injection shaft.04-18-2013
20130096531HYPODERMIC NEEDLE ASSEMBLY HAVING A TRANSITION HUB FOR ENHANCING FLUID DYNAMICS AND MICROSPHERE INJECTABILITY - A hypodermic needle assembly and a method of delivering a microsphere drug. A hypodermic needle assembly includes an injection needle; an injection device; and a hub defining a cavity including a transition portion having a first end and a second end between the first end and an inlet of the injection needle and having a gradually decreasing diameter from the first end to the second end, wherein the hub is coupled between the injection needle and the injection device such that the first end is in fluidic communication with an outlet of the injection device and the second end is in fluidic communication with the inlet of the injection needle, wherein the diameter of the cavity at the first end is larger than an outlet diameter of the injection device, and wherein the diameter at the second end is substantially the same as an inlet diameter of the injection needle.04-18-2013
20130102994SEALING ARRANGEMENT FOR SYRINGE - A syringe containing a high water content product and for use in a drug infusion system is provided. The syringe includes a plunger carrying front and rear o-rings made of a diene rubber compound such as chlorobutyl rubber or bromobutyl rubber to impart very low gas permeability characteristics to the o-rings. The plunger may be molded as a single part or in two parts. If molded as one part with radially-engaging mold portions, the seal glands in the plunger may include parting lines from the mold. If molded as two parts with axially-engaging mold portions, the front seal gland may include a sealing surface and under cut that has no parting line. The o-rings may be surface treated with a lubricant to improve sealing where the molding process gives rise to parting lines in the seal glands.04-25-2013
20130123747Device and method for preparing tissue, particularly adipose tissue - A device and a method for preparing adipose tissue for transplantation from lobular fat extracted, for instance by liposuction, the fat including a fluid component that have an oily component, a blood component and/or sterile solutions, and a solid component including cell fragments, cells and one or more cell macroagglomerates of heterogeneous size, wherein the device includes at least one washing and separating container having a washing chamber, the container has an inlet and an outlet for the liposuctioned material to enter the washing chamber through the inlet and for at least part of the material to exit the washing chamber through the outlet, the washing chamber including stirring means for forming an emulsion of fluid components.05-16-2013
20130123746TATTOO REMOVAL SYSTEM - Described is a system and associated materials and methods for delivering a fluid to a subject's skin, e.g., for tattoo removal. In one embodiment, the fluid is provided in a continuous flow by associating the fluid with a pump. In another embodiment, a disposable template is provided that allows for precise and ideal placement of eschar-inducing material fluid for, for example, tattoo removal.05-16-2013
20130131634Nucleus Augmentation Delivery Device and Technique - A method of performing a procedure on an intervertebral disc includes inserting a cannulated delivery tube through an opening in an annulus fibrosus of the intervertebral disc, positioning an expandable portion of the tube within the opening in the annulus fibrosus, expanding the expandable portion into contact with the annulus fibrosus about the opening to create a seal between the expandable portion and the annulus fibrosus, performing a procedure through the cannulated delivery tube within the annulus fibrosis, removing the tube, and closing the opening in the annulus fibrosus.05-23-2013
20130131633MODULAR INJECTION SYSTEM AND METHOD FOR DILUTING AN INJECTABLE FLUID - A modular injection system enables a user to control the dilution ratio of mixed injectable fluid. In one embodiment, modular injection system includes a handheld injection device operatively connected to a separate control device. In one embodiment, the control device includes a drive unit configured to apply extrusion forces to fluids. In another embodiment, the handheld injection device includes the drive unit. In one embodiment, the modular injection system produces the mixed injectable fluid based on a selected dilution ratio. In one embodiment, the modular injection system produces the mixed injectable fluid based on selected injection rates.05-23-2013
20130131632INJECTION DEVICE AND METHOD FOR DILUTING AN INJECTABLE FLUID - An injection device enables a user to control the dilution ratio of mixed injectable fluid. In one embodiment, the injection device includes a drive unit configured to apply extrusion forces to fluids. In one embodiment, the injection device produces the mixed injectable fluid based on a selected dilution ratio. In one embodiment, the injection device produces the mixed injectable fluid based on selected injection rates.05-23-2013
20130131635TISSUE TRANSFER SYSTEMS - Devices and methods for tissue transfer are described where a cannula may be inserted into the breast of a subject at one of several points of entry. Insertion of the cannula into the breast may be accomplished by using a guidance system to distinguish between tissue types. Once desirably positioned, the cannula may be withdrawn from the breast while automatically (or manually) injecting the fat in multiple deposits of adipose tissue or fat such that the deposited fat remains within the tract formed by the withdrawn cannula. Multiple tracts of the deposited fat may be injected within the breast until the breast has been desirably remodeled and/or augmented.05-23-2013
20130144259Catheter having proximal heat sensitive deflection mechanism and related methods of use and manufacture - Deflectable catheter systems, apparatuses and methods utilizing thermal expansion to influence catheter deflection. A representative embodiment includes a catheter having one or more pull wires or other tensioning elements. One end of the tensioning element(s) is connected at a distal portion of the catheter to facilitate shaft deflection upon pulling the tensioning element(s). A heat-sensitive control member(s) is coupled to a proximal portion of the tensioning element(s). The elongate tensioning element(s) is pulled in a proximal direction to deflect the distal portion of the catheter in response to a temperature change applied to the heat- sensitive control member.06-06-2013
20130144260DEVICE AND METHOD FOR THE CONTROLLED DELIVERY OF OPHTHALMIC SOLUTIONS - The present disclosure is directed to an injector device for delivering an ophthalmic solution to a cornea of an eye. The device may include a base configured to contact part of the eye, and a needle connected to the base, wherein needle may deliver the ophthalmic solution to the cornea.06-06-2013
20130144261STRUCTURES FOR TRANSDERMAL DRUG DELIVERY - A preparation for the transdermal delivery of a biologically active substance into the body of a patient comprises particles of a formulation comprising the active substance. The particles are irregular in size and shape and may be produced by a low cost manufacturing method such as grinding from a thin film. The particles are angular, i.e. they have sharp edges and corners that allow them to penetrate the outer layer of the skin when subjected to pressure from a roller or an array of blunt-tipped microstructures. Sucrose may be used as an excipient with the active substance to form suitably rigid and angular particles.06-06-2013
20130144256MEDICAL MARKING APPARATUS AND METHODS - The present invention provides the materials and methods related to marking the injection site on a patient's skin. Specifically, the present invention provides the materials and methods for applying a medical marking tattoo containing at least one injecting targeting site, injecting a medical substance into the area of the injection target site, and marking the injecting targeting site using a tattoo activation element. The present invention also provides the materials and methods for a medical marking apparatus that can be used to perform the methods of the present invention to mark the injection site on a patient's skin.06-06-2013
20130144257DEVICE FOR DELIVERY OF RHEUMATOID ARTHRITIS MEDICATION - Disclosed are devices for delivering a rheumatoid arthritis drug across a dermal barrier. The devices include microneedles for penetrating the stratum corneum and also include structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The pattern of structures on the surface of the microneedles may include nano-sized structures.06-06-2013
20130144258METHOD FOR DELIVERY OF ANTIMICROBIAL TO PROXIMAL END OF CATHETER - Systems, methods, and articles for delivering an antimicrobial composition into the lumen of a trans-dermal catheter and to proximal elements of the transdermal catheter are disclosed. In an embodiment, the system comprises an elongate member configured for insertion into a lumen of a catheter, the elongate member containing an antimicrobial. In an alternative embodiment, an antimicrobial composition placed on an interior surface a cap element, and transfers antimicrobial to the exterior of the proximal end of the transdermal catheter.06-06-2013
20110060310INTRACUTANEOUS INJECTION - The delivery of biopharmaceutical and other therapeutic agents parenterally to an animal via a minimally invasive, low pain administration is provided. The agents are delivered to the patient via, e.g., the epidermal, dermal, or subcutaneous layer of the skin in a concentrated fours of injectable paste of slurry.03-10-2011
20090247985EMBOLIC PARTICLE MIXING SYRINGE - A syringe device for agitating and delivering a liquid medication to a patient is provided. The device includes an injecting member, a first syringe, a second syringe and an accumulator. The first syringe is configured to provide the liquid medication to the device. The second syringe is configured to receive the liquid medication from the first syringe. The accumulator is biased to an empty position and cooperates with the second syringe to agitate the liquid medication back and forth between the second syringe and the accumulator. The second syringe is configured to move the liquid medication to the injecting member for patient delivery.10-01-2009
20130144255SYRINGE ASSEMBLIES INCLUDING A SAFETY SHIELD FOR A NEEDLE - A safety shield for use with a hypodermic syringe device is disclosed. The safety shield is moveable relative to the syringe barrel between refracted position and a needle containing position. In the retracted position, the syringe device may be used to inject the needle into the patient. After the needle has been withdrawn or as the needle is withdrawn from the patient, in its operative mode, the shield extends from its retracted position to a needle containing position to shield the point of the needle to prevent accidental sticks and to render the syringe unuseable after a single injection.06-06-2013
20130158507Biliary System Catheter - A catheter system and a method for accessing the bile duct are provided. The catheter system includes an elongate shaft having a proximal portion and a distal portion. The catheter also includes a first lumen extending at least partially through the elongate shaft, a distal portion of the first lumen extending generally parallel to a longitudinal axis of the elongate shaft and a distal port operably connected to the first lumen. The catheter system also includes a second lumen extending at least partially through the elongate shaft and a side port operably connected to the second lumen, the side port positioned proximal to the distal port and operably connected to the second lumen. The second lumen includes an angled wall portion adjacent to the side port. A marker is included on the distal portion of the elongate shaft, the marker configured to indicate the position of the side port.06-20-2013
20110213334SAFETY ASSEMBLY FOR A SYRINGE - A safety support device for a syringe comprises a support sheath (09-01-2011
20100286655Targeted Drug Delivery Device and Method - A targeted drug delivery device is provided. The device comprises an elongated member with proximal and distal ends, a plurality of infusion ports associated with the distal end of the elongated member, and a selector mechanism for selectively placing an introducer port into fluid communication with at least one infusion port. A method for treating tissue is also provided. The method comprises introducing a medical device into the tissue, selecting a region of the tissue to treat, positioning the medical device in proximity to the region, and introducing a medicament through the device to treat only that region.11-11-2010
20100286654Multiple Thermal Sensors in a Multiple Processor Environment for Temperature Control in a Drug Delivery Device - In various embodiments, an ophthalmic injection device may include a dispensing chamber, a first thermal sensor coupled to the dispensing chamber, a temperature control layer coupled to the dispensing chamber, a second thermal sensor coupled to the dispensing chamber, and a first processing device. The first processing device may be configured to receive temperature information from the first thermal sensor and the second thermal sensor and control the temperature control layer using the received temperature information. In some embodiments, the first processing device may receive temperature information directly from the second thermal sensor (e.g., in analog form) and may compare the temperature information from the first thermal sensor (e.g., received from the second processing device in digital form) and the second thermal sensor to detect temperature offsets between the two sensors.11-11-2010
20110276029NEEDLE BASED HELICAL COIL SAFETY DEVICE - The present disclosure describes anti-needle stick safety mechanism that is passively activated during the normal course of giving an injection. In one embodiment, the device includes a spring member coupled at a proximal end to a needle member and at a distal end to a needle cover. The passive activation of the device is triggered when the needle is inserted to a minimum depth into the patient's tissue to unleash the force of a compressed spring to urge a needle cover towards the distal end of the needle. As the needle is withdrawn from the tissue, the needle cover advances to the end of the needle and as it partially clears the end of the needle, it adopts an orientation that prevents the needle tip from re-emerging from the needle cover.11-10-2011
20110276028METHOD AND DEVICE FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE USING A MICROPROJECTION ARRAY - A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.11-10-2011
20110276027APPLICATORS FOR MICRONEEDLES - An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.11-10-2011
20110276026EXTENDED FINGER FLANGE FOR SYRINGE SYSTEMS - The present disclosure describes an extended finger flange that facilitate use of syringe systems. The extended finger flange increases the surface area available for an end user's fingers thereby allowing a more secure grip on the device and providing greater control during administrations of the medication.11-10-2011
20120277724Disposable Double Point Injection Needle and an Insulin Injection System Comprising a Disposable Double Point Injection Needle - A disposable double pointed injection needle has a needle hub to which a thin needle cannula is permanently fastened and which needle hub can be mounted on to a syringe comprising a dose setting and injection mechanism and a cartridge containing a liquid medicine to be injected subcutaneously into a human body. The needle hub is provided with a safety shield guided on the needle hub. The safety shield is urged in a direction away from the needle hub by a spring located between the needle hub and the safety shield. After injection the shield is moved away from the needle hub by the spring and locked in an irreversible position where the safety shield covers the needle cannula and prevents accidental needle stick injuries.11-01-2012
20130150825TISSUE TRANSFER SYSTEMS - Devices and methods for tissue transfer are described where a cannula may be inserted into the breast of a subject at one of several points of entry. Insertion of the cannula into the breast may be accomplished by using a guidance system to distinguish between tissue types. Once desirably positioned, the cannula may be withdrawn from the breast while automatically (or manually) injecting the fat in multiple deposits of adipose tissue or fat such that the deposited fat remains within the tract formed by the withdrawn cannula. Multiple tracts of the deposited fat may be injected within the breast until the breast has been desirably remodeled and/or augmented.06-13-2013
20130150826APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF BIOACTIVE SOLUTION - Apparatus for transdermal or subcutaneous delivery of a bioactive solution, including a plurality of needles fixed on a needle carrier in a spaced apart relationship and projecting from the needle carrier, each needle having a tip zone adapted to receive an amount of bioactive solution from a reservoir coupled to the needle carrier and to deliver the bioactive solution upon penetrating a skin.06-13-2013
20130150827MEDICAL DEVICE SECUREMENT SYSTEM - A securement device, system, and method for use with a medical article. The securement device, system, or method may include a body that has a top surface and a bottom surface. The bottom surface has an adhesive compound thereon. A resilient retainer formed from a soft, tacky elastomeric gel or foam is supported by the bottom surface of the body. The resilient retainer receives and secures a medical device. The medical device is secured to the skin of a patient upon affixing the bottom surface to the patient via the adhesive compound.06-13-2013
20090030399Drug Delivery Device and Method - The present invention is directed to a medical device and method for delivering a drug. The medical device includes a deformable body configured to be implanted between a first vertebra and a second vertebra for providing shock absorption and stabilization of the vertebras. The deformable body comprises an impermeable inner layer forming an interior volume and an outer layer at least a portion of which is permeable. The outer layer is at least partially outside the inner layer and forms an exterior volume between the inner and outer layers. The medical device further includes a drug reservoir connected to the deformable body and in fluid communication with the exterior volume. The medical device is capable of delivering the drug from the reservoir into the exterior volume and releasing the drug through the permeable portion of the outer layer.01-29-2009
20120283698SYRINGE GUARD WITH SELECTED NEEDLE CONFIGURATIONS - A device for expelling a fluid through a needle mounted on a hub includes an elongated luer member that has a distal portion dimensioned to engage the needle hub to provide fluid communication between the luer member and the needle. An adapter anchors the luer member within the device. Slidingly mounted on the adapter is a cylindrical-shaped inverted plunger that is movable thereon between an advanced position and a withdrawn position. A needle guard is biased by a biasing member to extend distally from the luer member when the plunger is in the advanced position. The guard is selectively engageable with the plunger to be retracted to expose the distal portion of the luer member for fluid engagement with the needle hub when the plunger is moved to the withdrawn position.11-08-2012
20120283697METHODS FOR STIMULATING A DORSAL ROOT GANGLION - Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.11-08-2012
20120283696Self-Injection Device with Multi-Position Cap - A self-injection device (11-08-2012
20120283695TRANSDERMAL DRUG DELIVERY PATCH AND METHOD OF CONTROLLING DRUG RELEASE OF THE SAME BY NEAR-IR - A transdermal drug delivery patch and a method of controlling the drug release of the transdermal drug delivery patch by near-IR are disclosed. The transdermal drug delivery patch comprises a substrate, carriers and drugs. The drugs are encapsulated in the carriers, and the carriers having the drugs are disposed on a surface of the substrate. The carriers are formed of biodegradable polymers, and nano-particles with a photothermal conversion effect are loaded in the carrier. When the carriers are punctured into the skin and the nano-particles in the carrier absorb the near-IR, the near-IR is converted into heat by the nano-particles to melt the carrier and thus releasing the drugs encapsulated in the carrier into the skin. Accordingly, the speed of releasing the drugs encapsulated in the carrier can be controlled accurately by the near-IR.11-08-2012
20130158508MULTIPLE DOSAGE INJECTOR - A medicament dispensing mechanism is disclosed that is configured to eject successive doses of the medicament from a medicament chamber. An embodiment of the dispensing mechanism includes a housing and a plunger rod configured for ejecting the doses of medicament from the chamber. The dispensing mechanism further includes an actuation mechanism that comprises a trigger associated with the housing and having a ready and a fired position with respect thereto. The trigger is configured for manipulation by a user for successive movement in a generally axial dosing motion from the ready position to the fired position in which the trigger is associated with the plunger rod to cause the plunger rod to eject one of the doses of a predetermined volume and a resetting motion from the fired position to the ready position that comprises axial rotation, wherein the trigger is uncoupled from the plunger rod during the resetting motion.06-20-2013
20130158505MEDICAL DEVICES FOR DELIVERY OF siRNA - Disclosed are medical devices that incorporate siRNA. In addition to one or more siRNA constructs, devices include nanostructures fabricated on a surface to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Microneedles may be incorporated on devices. The pattern including nanostructures may be formed on the surface of the microneedles.06-20-2013
20130184677Multiple Dose Syringe and Method - A multiple dose syringe has a first valve defining a first valve opening pressure and a second valve defining a second valve opening pressure. A storage chamber in fluid communication with the second valve stores multiple doses of a substance therein and includes an outlet for dispensing multiple doses of the stored substance therethrough. A compression surface is movable between first and second positions and defines a compression chamber between the compression surface and the first valve. Movement of the compression surface in a direction from the first position toward the second position dispenses substance in the compression chamber through the first valve and out of the syringe. Movement of the compression surface in a direction from the second position toward the first position causes substance to flow from the storage chamber through the second valve and into the compression chamber.07-18-2013
20130184678DUAL ACTION SYRINGE - In one aspect, a dual action syringe includes an external body having a distal end defining an anesthetic gel receptive concavity surrounding a needle passage through the distal end. The external body also includes a proximal end defining a plunger receptive passage. An internal body is slidably disposed in the external body. The internal body receives a needle in a distal end of the internal body and an anesthetic carpule to provide fluid flow communication between the carpule and the needle in response to pressure on the plunger. A biasing member is disposed in the external body, between the external body and the internal body, biasing a distal end of the needle away from the distal end of the external body into the external body; whereby, pressure on the plunger first moves the needle through the needle passage and subsequently provides fluid flow communication between the carpule and the needle.07-18-2013
20130184675Infusion Monitoring Device and Method for Monitoring the Infusion Dripping Rate and Alarming for the Irregularities of the Infusion - The present invention discloses an intravenous infusion monitoring device for monitoring the infusion dripping rate. This device is attached to an infusion tube above the dripping chamber, including two polar plates forming a capacitor, a capacitance measurement unit electrically connected to the capacitor, a micro control unit (MCU) configured to collect data from the capacitance measure unit and analysis and display the infusion dripping rate. A method for monitoring infusion rate includes setting the infusion solution surface to a specific height in the dripping chamber so that the infusion solution in the tube is conducted and have a pulse change of the capacitance at the moment when a droplet drips down, determining the cycle of the pulse corresponding to the infusion rate and displaying the dripping rate by LCD screen, and alarming when the infusion irregularities occurs such as too fast, too slow or fully stop.07-18-2013
20130184676System, Method, and Apparatus for Estimating Liquid Delivery - A pump for administering an agent to a patient includes a housing, a motor, a gearbox, a sensor, and a controller. The motor may be coupled to housing. The gearbox is operatively connected to said motor. The sensor senses a rotation of said motor. The controller acts to control operation of said motor and monitor the quantity of said agent delivered to said patient. The pump also includes a pump assembly such that the pump is configured such that the pump assembly may be interchangeable from a syringe pump assembly and a peristaltic pump assembly.07-18-2013
20110282323INFILTRATION CANNULA - An infiltration cannula and method of using the infiltration cannula during a tumescent infiltration procedure are disclosed herein. The infiltration cannula may have an outwardly flaring hub which may be wedged into an adit of a patient to minimize leakage of fluid being infiltrated into the patient. Also, the infiltration cannula may be utilized to hydrate a dehydrated patient by a medically untrained person. The infiltration cannula may also be used to deliver an antibiotic/vasoconstrictive drug solution to minimize surgical site infections.11-17-2011
20110282322Hemodialysis Access Needle Assembly System and Method - An access needle assembly for use with implanted hemodialysis access ports is disclosed. In some embodiments, the assembly includes the following: a tubular needle having an internal cavity including an open leading end having a beveled edge and an open trailing end opposite the leading end, the cavity including a side outflow opening adjacent the trailing end; an obturator configured to be removably positioned within the tubular needle; an interface portion including a central cavity so that the interface portion is positioned adjacent the opening, the interface including a flanged portion extending substantially perpendicular from the central cavity and positioned concentrically over the opening; a conduit portion fluidly connected with the cavity via the flanged portion; and a depth block joined with the interface portion below the flanged portion, the depth block including a lower end opposite the interface portion.11-17-2011
20110288526Pen Needle Assembly For Intradermal Injection - A pen needle assembly (11-24-2011
20130123748TOOLS AND METHODS RELATED TO CATHETER DELIVERY - A syringe adapter tool facilitates inline connection of a syringe with a catheter lumen, as well as torque transfer between the syringe and catheter. The adapter tool may further facilitate passage of an instrument through a seal zone portion of the catheter lumen, which seal zone portion is located in a proximal section of the catheter.05-16-2013
20130096532Polymer-Based Micro-Needle Array Designs, Fabrication Processes, and Methods of Use Thereof for Drug Delivery - A micro-needle array is provided that may be used to deliver a bioactive agent to a therapeutic target. The micro-needle array preferably includes a substrate, a plurality of micro-needles integral with the substrate, and a bioactive agent. At least one micro-needle preferably includes a top surface, a bottom surface, a side surface, and a cavity defined by an inner surface. The bioactive agent may be disposed on the substrate and the plurality of micro-needles. The at least one micro-needle may further include a slit connecting the cavity to an aperture, the slit extending from the top surface to the bottom surface. A plurality of micro-needles on a patch is also disclosed for transdermal drug delivery applications.04-18-2013
20110313399INTRAVENOUS CANNULA - An intravenous (IV) cannula comprising an elongated body including a distal section for insertion into a blood vessel; at least one channel extending along at least a portion of a longitudinal axis of said cannula section, the at least one channel configured to maintain an amount of at least 10% of a blood flow in the blood vessel; and a central lumen configured to allow an IV fluid flow into the blood vessel.12-22-2011
20110313398AUTOMATIC INJECTION DEVICES - An injection device comprises a syringe extendible against a spring bias from a retracted position in a housing to a projecting injecting position. A spring biased plunger has collapsible elbows which, when the plunger is released, initially engage the end of the syringe to drive it to the projecting position, whereupon arresting of the syringe movement causes the elbows to collapse inside the syringe to allow the plunger to engage and drive the bung.12-22-2011
20110313397Adjustable plunger dose stop - A syringe includes a body for receiving a liquid medicament and a collar rotatably disposed in or on the body. The collar is rotatable to set a desired dose. A plunger is movably disposed in the collar. The plunger is movable to draw in and dispense the liquid medicament. An end of the collar limits movement of the plunger such that an accurate dose is drawn.12-22-2011
20110313396Adjustable dose setting plunger for syringe - A syringe includes a body for receiving a medicament and a plunger movably connected to the syringe body. The plunger is moved with respect to the syringe body to draw in and dispense the medicament. A plurality of dose setting indicators are disposed on the plunger. The plunger is rotated outwardly from the syringe body to draw medicament into the syringe body. The plunger can be pushed or rotated into the syringe body to dispense the medicament.12-22-2011
20130190718BONE GRAFT DELIVERY DEVICE - Aspects of the claimed invention relate generally to devices for delivering bone graft compositions to implants that have been positioned between vertebral bodies during surgery and methods of using such devices. Embodiments of the invention provide ease of bone graft delivery in situ while providing an environment for the mixing of bone graft, insertion of the bone graft, and packing of the graft into the voids above and below the implant.07-25-2013
20130190722AUTO-INJECTOR - The invention refers to an auto-injector for administering a medicament (M) and to a method for operating it, the auto-injector comprising of a tubular chassis and a carrier subassembly, comprising a tubular carrier slidably arranged in the chassis. The carrier contains a syringe, a drive spring and a plunger for forwarding load of the drive spring to a stopper arranged in the syringe. The syringe is locked for joint axial translation with the carrier. A control spring is connectable to the carrier by first interlock means for needle insertion, wherein the whole carrier subassembly is advanced. Second interlock means are arranged for releasing the drive spring when the carrier has at least almost reached an injection depth thus delivering the medicament (M). The first interlock means are arranged for decoupling the control spring from the carrier and coupling it to the chassis for advancing it over the needle into a needle safe position.07-25-2013
20130190719DRUG DELIVERY DEVICE WITH DRIVE MEMBER HAVING INDICATION ELEMENTS - A drug delivery device is proposed, which comprises a housing, a drive member which is movably retained within the housing, a piston rod which is operatively coupled to the drive member, wherein the drug delivery device is configured to convert movement of the drive member with respect to the housing into movement of the piston rod with respect to the drive member, wherein a surface of the drive member is provided with one or a plurality of indication elements, and wherein the drug delivery device is adapted to display at least one of the indication elements through the housing. Furthermore it is proposed to use a single member in a drug delivery device for driving movement of a piston rod of the device and for displaying dose related information to a user of the device.07-25-2013
20130190721AUTO-INJECTOR - The invention refers to an auto-injector and to a method for operating it, the auto-injector comprising of a tubular chassis; a carrier subassembly comprising a tubular carrier slidably arranged in the chassis, the carrier containing a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe; a wrap-over trigger sleeve arranged over the distal end (D) of the auto-injector; the trigger sleeve extending at least almost over the whole length of the auto-injector; a control spring arranged around the carrier; first interlock means for coupling a proximal end of the control spring to either the carrier for advancing it for needle insertion or to the chassis for needle retraction; second interlock means arranged for releasing the drive spring for injection; third interlock means arranged for coupling the chassis to the carrier for joint axial translation relative to the trigger sleeve; and fourth interlock means arranged for coupling a distal end of the control spring to either the carrier for needle retraction or to the trigger sleeve otherwise.07-25-2013
20130190720BULKING AGENTS - The invention relates to bulking agents and apparatus and methods for using the disclosed bulking agents. The bulking agents can be used to treat such conditions as urinary and fecal incontinence, gastro-esophageal reflux, aneurismal blockages, and cosmetic deformities. The invention also relates to an injection method that reduces the injection pressure required to place the bulking agents.07-25-2013
20120022500Compositions and Methods for Induced Brown Fat Differentiation - The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of both Prdm1β and C/EBPβ activity and/or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of both Prdm1β and C/EBPβ expression and/or activity. Further provided are methods for identifying compounds that are capable of modulating both Prdm1β and C/EBPβ expression and/or activity.01-26-2012
20120029470POSTERIOR SEGMENT DRUG DELIVERY - A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.02-02-2012
20120029469Lubricated pen needle - A pen needle (02-02-2012
20130197475INJECTOR - An injector for delivering medicament comprises a collapsible container (08-01-2013
20130197477NEEDLE ASSEMBLY WITH RELEASE MECHANISM - A needle assembly comprises a body configured for attachment to a drug delivery device. The body defines a cavity. A septum is positioned within the cavity and a stopper positioned within the cavity such that the cavity, septum, and stopper define a reservoir. A double ended needle is positioned in the stopper and septum, the needle comprising a proximal end and a distal end. A release mechanism is positioned near a distal end of the body. A biasing element is positioned to drive the stopper. During a dose dispensing step, the release mechanism drives the proximal end of the needle out of the septum so that the proximal end resides in said reservoir. The biasing element may also drive the stopper proximally.08-01-2013
20130197474Medicated Module Having a Double Needle Guard - A medicated module (08-01-2013
20130197476Catheter for Positioning a Wire Guide - A system and a method of positioning a wire guide are provided. The method includes inserting a wire guide in a first configuration into a lumen of a catheter, distally advancing the wire guide to a distal portion of the lumen so that a distal end of the wire guide is distal to an opening in a wall of the catheter and advancing a distal portion of the wire guide through the opening by distally advancing the distal portion relative to the catheter so that the distal end remains in the lumen as the distal portion of the wire guide extends out of the opening. The method includes advancing the distal portion of the wire guide further out of the opening so that the distal end exits through the opening so that the distal portion is distal to the distal end of the wire guide in a second configuration.08-01-2013
20130197478DOSE SETTING MECHANISM AND METHOD OF USING SAME - The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a drug delivery device housing, a dose dial sleeve positioned at least partly in the housing and being rotatable during dose setting and dose delivery, a clutch rotatable during dose setting and non-rotatable during dose delivery, and a clutch nut, that is threadedly engaged with the clutch and is splined to the housing to prevent rotation of the clutch nut.08-01-2013
20130197479Dose Setting Mechanism and Method of Setting a Dose - A method and system for preventing delivery of less than a predetermined minimum dose of a medicament by providing a dose setting mechanism having a spindle nut and a sprung lock nut. The mechanism includes a housing and a dose dial component positioned in the housing. The dose dial component is rotatable during a dose setting step. The mechanism further includes a drive sleeve positioned within the dose dial component. The drive sleeve is configured to drive a rotatable spindle during a dose administration step. The spindle nut is coupled to the spindle and the sprung lock nut is removably coupled to the drive sleeve and rotationally fixed to the housing. In one arrangement, when the dose dial component is rotated to select a dose less than a preselected minimum dose, the sprung lock nut allows the spindle nut to rotate thereby preventing the dose from being administered.08-01-2013
20130204229PALM ACTIVATED DRUG DELIVERY DEVICE - A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.08-08-2013
20130204224CONTROLLING A MOTOR OF AN INJECTION DEVICE - In order to improve the energy efficiency of an injection device 08-08-2013
20130204225SAFETY SYRINGE AND SAFETY DOSE COMBINATION KIT - Methods, apparatuses, and systems are disclosed for reducing Medical Administered Errors, (MAE) in the administration of injectable medications to patients by using a syringe device that is designed, labeled, and calibrated to decrease the risk of such errors. The syringe may be designed for a specific medication, and labeled to indicate the name of the medication for which it was designed. The syringe is calibrated to deliver a specific amount of the medication that is the appropriate dosage for a patient of a particular weight or other feature, thereby making it unnecessary for the user to perform calculations to determine the correct dosage volume for the particular patient. The syringe may also be calibrated with additional measurement scales that enable the user to verify that the correct dosage.08-08-2013
20130204226Pressure Actuated Catheter Valve - This invention provides catheter assemblies and methods for insertion of a catheter into a vessel. The assemblies include a resilient valve in the hub of the catheter that can be opened by pressure from a male luer fitting. The methods include piercing a vessel with the needle and catheter of the assembly, retraction of the needle component thus closing the resilient valve. Finally the catheter can be accessed by applying a male luer fitting to the catheter hub and a shoulder of the resilient valve.08-08-2013
20130204227Medication Injection Site and Data Collection System - A medication delivery apparatus for use with a medication container includes a housing, a fluid conduit at least partially extending within the housing and configured to deliver medication within the medication container to a patient, a medication port extending from the housing and configured to be coupled to a fluid outlet of the medication container, the medication port being fluidically coupled to the fluid conduit, and at least one sensor disposed within the housing to generate information characterizing administration of the medication for processing by a remote data collection system. The housing can have a size and shape that enables it to be supported by a first hand of a user while the user administers the medication from the medication container via the medication port using a second hand of the user. Related apparatus, systems, and techniques are also described.08-08-2013
20130204228PUNCTURABLE MEMBRANE FOR SAFETY SYRINGE - A safety syringe may define a variable fluid chamber and detached needle assembly. The variable fluid chamber may be hermetically sealed off from the environment or ambient air until the needle assembly is attached to a syringe body of the safety syringe. A proximal end of the variable fluid chamber is sealed off from the environment via a seal between a piston and syringe body. The distal end of the variable fluid chamber may be sealed off from the environment via a barrier covering the distal end of the syringe body. The barrier may be punctured to allow fluid to through therethrough at or about the same time when the needle assembly is attached to the distal end portion of the syringe body.08-08-2013
20120095441STEM CELL DELIVERY DEVICE FOR ORTHOBIOLOGICS APPLICATIONS - A method and apparatus for thawing and delivery of cryogenically frozen biological material, such as stem cells includes a housing for receiving a pouch of frozen cells, a heating element against which the pouch is placed for applying defrosting heat to the pouch, and a squeezing apparatus for applying a squeezing force to the pouch after or upon thawing of the cells. The squeezing force may be applied by a roller pressing the pouch against the heating element, which forces the thawed cells from a needle or tube connected to the housing and/or to the pouch. A rechargeable battery in the housing supplies power to the heating element and the squeezing apparatus.04-19-2012
20130211373Method of Managing History of Injection of Medicinal Fluid - The present invention relates to a method of managing a history of the injection of a medicinal fluid. More particularly, the present invention relates to a method of managing a history of the injection of a medicinal fluid, which is capable of managing the history of the injection of a medicinal fluid in an apparatus for injecting a medicinal fluid that automatically injects a predetermined volume of medicinal fluid into a vein or epidural space of a patient in order to manage the pain of the patient.08-15-2013
20130211374Injection Control Device for Proportional Injection, Extraction during the Syringe's Insertion, Retraction - An injection control device (ICD) for a syringe, injects/extracts material into/from at a rate controllably proportional to the rate of movement of the syringe. The device has body with a first and opposite second side, syringe holder, first aperture in the first side to accommodate a cannula of the accommodated syringe, second aperture in the first side, and third aperture in the second side. A positionable transmission reference member may be linearly extendable from the second aperture; a spooling rotating member with an axle is coupled to the body; a clutch is coupled to the rotating member; and a transmission system is interior to and coupled to the body which translates body motion, in relation to a fixed state of the reference member, to move the plunger of the syringe, causing injected/extracted of material into/from a subject as the syringe's cannula is traveling with the moving body.08-15-2013
20130211375Syringe Devices, Components of Syringe Devices, and Methods of Forming Components and Syringe Devices - Syringe assemblies are provided that can include a valve within a plunger having a fluid channel extending longitudinally therethrough and along the channel, the valve including a piston extending substantially normally to the channel and configured to slidably engage the plunger along the extension. Syringe assemblies can also include: a syringe barrel having a first cross sectional diameter; a syringe piston configured to operatively couple with the barrel; a fluid channel extending the length of the piston; a vial port extending from an end of the piston, the vial port having a second cross sectional diameter, the second diameter being greater than the first diameter. Methods for controlling fluid along a fluid channel within a syringe plunger are also provided. The methods can include extending a piston in one direction normally to the fluid channel to provide fluid communication between two sections of the fluid channel.08-15-2013
20130211376CLOSURE CONTAINER FOR SINGLE DOSE DISPOSABLE PHARMACEUTICAL DELIVERY SYSTEM - Provided herein is a single dose disposable pharmaceutical delivery apparatus and methods of use and manufacture thereof. One aspect provides a single dose disposable pharmaceutical delivery apparatus that includes a needle hub seal attached to a needle hub and a bladder that can contain a pharmaceutical composition. Another aspect provides for dispensing a pharmaceutical composition from the delivery apparatus by rupturing the needle hub seal and fluidically connecting the needle and the bladder. Another aspect provides manufacturing the delivery apparatus according to steps including attaching a needle hub and a needle hub seal and combining the bladder and the needle hub, thereby forming an apparatus described herein.08-15-2013
20130211377Dose Setting Mechanism for a Drug Delivery Device - The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a housing, a mechanism member movable in a first axial direction relative to the housing during dose setting and movable in a second, opposite axial direction relative to the housing during injection, wherein the mechanism member is designed and arranged such that the mechanism member is able to change its condition between a first condition preventing movement in the second axial direction and a second condition allowing movement in the second axial direction, and a switching member forcing the mechanism member to change from its second condition into its first condition at a predefined position of the movement in the first axial direction during dose setting.08-15-2013

Patent applications in class Therapeutic material introduced or removed through a piercing conduit (e.g., trocar) inserted into body

Patent applications in all subclasses Therapeutic material introduced or removed through a piercing conduit (e.g., trocar) inserted into body