| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 604504000 | By measurement of a metabolite concentration (i.e., glucose) | 79 |
| 20100057043 | Method, System, and Computer Program Product for the Detection of Physical Activity by Changes in Heart Rate, Assessment of Fast Changing Metabolic States, and Applications of Closed and Open Control Loop in Diabetes - A method, system, and computer program product related to the detection of physical activity using changes in heart rate. The method, system, and computer program product evaluates short term glucose demand and long term insulin action due to physical activity. The method, system, and computer program product is further related to the improvement of open and closed loop control of diabetes by accounting for the metabolic changes due to physical activity. The method, system, and computer program product is directed to detecting in real time the short and long term effects of physical activity on insulin action via heart rate analysis, and recommending changes in insulin dosing to compensate for the effects of physical activity. With these recommendations, the open and closed loop control of diabetes can be improved and steps can be taken to prevent hypoglycemia that may result from increased insulin sensitivity due to physical activity. | 03-04-2010 |
| 20130041343 | INSULIN PUMP - The present invention relates to a controller unit and methods for controlling an insulin pump. The controller unit includes a user input that receives a gain factor. The gain factor has been calculated based on historical data in relation to a patient. The controller unit includes a measurement input for receiving data representative of a measured blood glucose level for the patient. Processing logic of the controller unit is configured to apply the measured blood glucose level to a pancreatic beta-cell insulin secretion computational model to predict an insulin output level, apply the gain factor to the predicted insulin output level to determine a patient insulin deficiency level, and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level. Methods are provided for optimising the gain factor based on the historical data in relation to the patient. | 02-14-2013 |
| 20130046281 | Closed Loop Infusion Formulation Delivery System - A closed loop infusion formulation delivery system for controlling a biological state in the body of a user includes a sensor for generating a signal representative of measured parameters and a computing element for processing the generated signal. The computing element adjusts control parameters within an algorithm, calculates a delivery rate of an infusion formulation and generates commands based on the calculated delivery rate. A remotely located monitoring station communicates with the computing element via radio or wire to further adjust the control parameters within the algorithm to meet changing needs in the body of the user. | 02-21-2013 |
| 20130090625 | COORDINATION OF CONTROL COMMANDS IN A MEDICAL DEVICE SYSTEM HAVING AT LEAST ONE THERAPY DELIVERY DEVICE AND AT LEAST ONE WIRELESS CONTROLLER DEVICE - A medical device system includes at least one controllable patient-worn or patient-carried medical device, and a plurality of controller devices that are capable of independently controlling features or functions of the patient medical device. Control commands and other data is wirelessly communicated among the patient medical device and the multiple controller devices. A number of techniques, protocols, and other measures are provided to coordinate wireless communication between the various devices in a medical device system. These control command coordination processes address situations where conflicting, redundant, or concurrent control commands might be independently issued by the multiple controller devices. | 04-11-2013 |
| 20130096530 | METHOD OF MONITORING SAFETY IN MEDICATION DELIVERY FOR DIABETES MANAGEMENT - Glucose sensor signals and medication delivery control signals are monitored and these signals are modified for compatibility and safety purposes. In one application, output control signals from a controller directed to a delivery device are modified as a function of an actual amount of insulin delivered to the user. The safety layer method allows for an increased level of safety in an integrated delivery management (“IDM”) system and permits the development of separate hardware and software upgrades for components of the IDM system while assuring that compatibility between components will continue and safety is increased. | 04-18-2013 |
| 20130131630 | PROGRAMMABLE INSULIN PUMP - An apparatus for delivering a bolus of a medical agent to a patient. The apparatus comprises a pump mechanism, a data input device, and a processor in data communication with the keypad and arranged to control the pump mechanism. The processor is programmed to receive data specifying a bolus amount through the data port, receive data regarding duration through the data port, receive a percentage through the data port, the percentage defining a portion of the bolus amount to deliver immediately upon executing a deliver command and a remainder of the bolus amount to deliver over the duration upon executing a deliver command, and execute the deliver command thereby controlling the pump mechanism to deliver the bolus. Also a method of temporarily adjusting the delivery rate of an infusion pump. The infusion pump is programmed to deliver a basal rate. The method comprises prompting a user to select whether to enter the temporary rate as a percent of the current delivery rate or as a new delivery rate; entering into the pump a period of time having a beginning and an end; entering into the pump a temporary basal rate; and delivering the therapeutic agent at a delivery rate substantially equal to the temporary basal rate during the period of time. | 05-23-2013 |
| 20130131631 | Diabetes Care Kit That Is Preconfigured To Establish A Secure Bidirectional Communication Link Between A Blood Glucose Meter And Insulin Pump - A diabetes care kit for providing diagnostics and therapy that is preconfigured to reduce initial setup by a user. The kit can include a handheld diabetes managing device and insulin pump. The handheld diabetes managing device and insulin pump can each be preloaded with an encryption key such that the handheld diabetes managing device and the insulin pump are paired and a secure bidirectional communication link exists between the handheld diabetes managing device and the insulin pump. | 05-23-2013 |
| 20110264071 | FLUID COMPONENT ANALYSIS SYSTEMS AND METHODS FOR GLUCOSE MONITORING AND CONTROL - Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. | 10-27-2011 |
| 20110282321 | MODEL PREDICTIVE METHOD AND SYSTEM FOR CONTROLLING AND SUPERVISING INSULIN INFUSION - A system and method for controlling and monitoring a diabetes-management system through the use of a model that predicts or estimates future dynamic states of glucose and insulin from variables such as insulin delivery or exogenous glucose appearance as well as inherent physiological parameters. The model predictive estimator can be used as an insulin bolus advisor to give an apriori estimate of postprandial glucose for a given insulin delivery profile administered with a known meal to optimize insulin delivery; as a supervisor to monitor the operation of the diabetes-management system; and as a model predictive controller to optimize the automated delivery of insulin into a user's body to achieve a desired blood glucose profile or concentration. Open loop, closed-loop, and semi-closed loop embodiments of the invention utilize a mathematical metabolic model that includes a Minimal Model, a Pump Delivery to Plasma Insulin Model, and a Meal Appearance Rate Model. | 11-17-2011 |
| 20110282320 | MODEL PREDICTIVE METHOD AND SYSTEM FOR CONTROLLING AND SUPERVISING INSULIN INFUSION - A system and method for controlling and monitoring a diabetes-management system through the use of a model that predicts or estimates future dynamic states of glucose and insulin from variables such as insulin delivery or exogenous glucose appearance as well as inherent physiological parameters. The model predictive estimator can be used as an insulin bolus advisor to give an apriori estimate of postprandial glucose for a given insulin delivery profile administered with a known meal to optimize insulin delivery; as a supervisor to monitor the operation of the diabetes-management system; and as a model predictive controller to optimize the automated delivery of insulin into a user's body to achieve a desired blood glucose profile or concentration. Open loop, closed-loop, and semi-closed loop embodiments of the invention utilize a mathematical metabolic model that includes a Minimal Model, a Pump Delivery to Plasma Insulin Model, and a Meal Appearance Rate Model. | 11-17-2011 |
| 20120191063 | INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR - Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction. | 07-26-2012 |
| 20120191062 | INSULIN PUMP HAVING A SUSPENSION BOLUS - A method of delivering insulin to compensate for suspension of basal insulin delivery and an insulin pump are disclosed. The method includes prompting a user to input a period in which to suspend delivery of insulin from an insulin pump. The method also includes calculating an amount of insulin to be delivered during the period. The method further includes prompting the user to select a portion of the amount of insulin. The method includes delivering the portion of the amount of insulin to the patient. The method also includes suspending basal delivery of insulin from the pump. | 07-26-2012 |
| 20100057040 | Robust Closed Loop Control And Methods - Methods, system and devices for monitoring a closed loop control operation including signal levels received from an analyte sensor and automatic delivery of medication at least in part in response to the received analyte sensor signals, determining whether the signal level received from the analyte sensor is associated with one of a fault condition or a potential fault condition, and dynamically adjusting a current infusion rate executed by the closed loop control operation when it is determined that the signal level from the analyte sensor is associated with one of the fault condition or potential fault condition, where medication delivery rate is adjusted to a first predetermined range when the signal level is associated with the fault condition, and adjusted to a second predetermined range when the signal level is associated with a potential fault condition, and where the first predetermined range is narrower compared to the second predetermined range are provided. | 03-04-2010 |
| 20090281519 | AUTOMATED SYSTEM AND METHOD FOR DIABETES CONTROL - An automated method and system of diabetes control. The method includes establishing a blood glucose target for an insulin user, measuring an existing blood glucose level for the insulin user, and inputting the existing blood glucose level into a computer processor formed to execute an algorithm designed to calculate a corrective amount of insulin to be administered intravenously in an integrated basal-bolus manner to the insulin user if the existing blood glucose level exceeds the blood glucose target. The algorithm is based on a plurality of factors that contribute to a non-linear glucose response. The method further includes automatically delivering the corrective amount of insulin to the insulin user, and further repeating the measuring, inputting, and delivering steps one or more times to maintain the insulin user within the blood glucose target range. | 11-12-2009 |
| 20110172635 | Infusion Pump Systems and Methods - Some embodiments an infusion pump system can be used to determine a user's total insulin load (TIL) that provides an accurate indication of the insulin previously delivered to the user's body which has not yet acted. In particular embodiments, the TIL can account for both the bolus deliveries and the basal deliveries that have occurred over a period of time. Such information may be useful, for example, when the infusion pump is operated in conjunction with a continuous glucose monitoring device. | 07-14-2011 |
| 20090264856 | SAFETY LIMITS FOR CLOSED-LOOP INFUSION PUMP CONTROL - A system and process for providing safety limits on the delivery of an infusion formulation by an infusion pump system in response to a sensed biological state. The safety limits may comprise user-initiated event signals corresponding to events that may significantly affect the biological state. The safety limits may further comprise user-initiated event ranking signals for respective events which specify a degree, quantity, or measure for the respective event. The user-initiated event and event ranking signals may be communicated to a computing element associated with the infusion pump by an associated communication device having a user interface which comprises a plurality of user-selectable operators for entering information about the events and event rankings. | 10-22-2009 |
| 20080200897 | MODULAR COMBINATION OF MEDICATION INFUSION AND ANALYTE MONITORING - Methods and systems for providing modular components in an integrated infusion device and analyte monitoring system where the components are independently replaceable are provided. | 08-21-2008 |
| 20110208156 | SYSTEMS, DEVICES AND METHODS TO DELIVER BIOLOGICAL FACTORS OR DRUGS TO A SUBJECT - A method, computer implemented method and associated apparatus for the management of diabetes is provided. | 08-25-2011 |
| 20080281290 | Reciprocating Delivery Of Fluids To The Body With Analyte Concentration Monitoring - A volume of an analyte-enriched fluid can be withdrawn out of a user's subcutaneous compartment using a patch unit that includes a reversible pumping mechanism. The volume can be withdrawn out of the body and into the patch unit through a cannula inserted into the subcutaneous compartment so that an analyte concentration in the volume can be measured using a sensing element within the patch unit. After analyte concentration analysis, at least the volume can be delivered back into the subcutaneous compartment by operating the pumping mechanism in a forward direction. biologically compatible fluid can optionally be pumped into the subcutaneous compartment from a reservoir in the patch unit and then allowed to partially or completely equilibrate with the analyte concentration in the interstitial fluid of the subcutaneous compartment via a permeable or semi-permeable cannula surface before being drawn back into the patch unit for analysis. Related systems, apparatus, methods, and/or articles are also described. | 11-13-2008 |
| 20120296311 | INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR - Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction. | 11-22-2012 |
| 20090030398 | Device and method for preventing hypoglycemia - A device and a method are provided that can be used for prevention of hypoglycemia. In one aspect, a device and a method for prevention of hypoglycemia can comprise receiving a target blood glucose (TBG) level corresponding to a desired level of glucose in a patient's body during a fasting time period; receiving a bedtime blood glucose (BBG) level corresponding to the level of glucose in the patient's body substantially at the beginning of the fasting time period; receiving a first set of parameters corresponding to a medical state of the patient; providing the levels of the TBG, BBG and the medical state of the patent to a therapeutic course of action determining means; and, providing means for administering the therapeutic course of action to the patient. | 01-29-2009 |
| 20080262469 | INTEGRATED MEDICAMENT DELIVERY DEVICE FOR USE WITH CONTINUOUS ANALYTE SENSOR - An integrated system for the monitoring and treating diabetes is provided, including an integrated receiver/hand-held medicament injection pen, including electronics, for use with a continuous glucose sensor. In some embodiments, the receiver is configured to receive continuous glucose sensor data, to calculate a medicament therapy (e.g., via the integrated system electronics) and to automatically set a bolus dose of the integrated hand-held medicament injection pen, whereby the user can manually inject the bolus dose of medicament into the host. In some embodiments, the integrated receiver and hand-held medicament injection pen are integrally formed, while in other embodiments they are detachably connected and communicated via mutually engaging electrical contacts and/or via wireless communication. | 10-23-2008 |
| 20100274220 | Method and System for Providing Basal Profile Modification in Analyte Monitoring and Management Systems - Method and system for providing basal profile modification in insulin therapy for use with infusion devices includes periodically monitoring the analyte levels of a patient for a predetermined period of time in order to determine, based on the monitored analyte levels, an appropriate modification factor to be incorporated into the underlying basal profile which was running at the time the periodic monitoring of the analyte levels were performed. | 10-28-2010 |
| 20110112505 | SYSTEM AND METHOD FOR PROVIDING CLOSED LOOP INFUSION FORMULATION DELIVERY - A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands. | 05-12-2011 |
| 20080269714 | CLOSED LOOP/SEMI-CLOSED LOOP THERAPY MODIFICATION SYSTEM - A closed loop/semi-closed loop infusion system provides therapy modification and safeguards against the over-delivery or under-delivery of insulin. A glucose sensor system is configured to obtain a measured blood glucose value. A controller is operationally connected with the glucose sensor system and configured to trigger an alarm based on a measured blood glucose value or amount of insulin delivered, selectively perform calibration of the glucose sensor system when the alarm is triggered, and adjust a therapy delivery parameter when the alarm is triggered, wherein the adjusted therapy delivery parameter is limited to be within a boundary. Thereafter, a delivery system delivers therapy at the adjusted therapy delivery parameter. | 10-30-2008 |
| 20110112506 | SYSTEM AND METHOD FOR PROVIDING CLOSED LOOP INFUSION FORMULATION DELIVERY - A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands. | 05-12-2011 |
| 20100262117 | PREDICTIVE CONTROL BASED SYSTEM AND METHOD FOR CONTROL OF INSULIN DELIVERY IN DIABETES USING GLUCOSE SENSING - A system and method for providing optimal insulin injections to a subject, using a controller, a continuous glucose monitor, and an insulin delivery unit is disclosed. The controller possesses a discrete-time, linear model predictive control law, means for sending information to the insulin delivery unit, and means for receiving information from the CGM. The control law implemented is derived from a discrete-time model of glucose insulin dynamics and an aggressiveness parameter. The result is that using only glucose measurements obtained from sensor readings and, prior values of external insulin infusion and meal and exercise announcement the optimal insulin injection necessary to safely regulate blood glucose can be calculated. | 10-14-2010 |
| 20110034901 | VAGINAL CARRIER FOR THE CONTROLLED RELEASE OF SUBSTANCES - A device that delivers one or more substances into a vaginal lumen according to one of a plurality of release patterns. The device comprises a supporting structure, substance dispensers, and/or coupling elements which are configured to release one or more substances, for example, drugs, in manner designed to optimize treatment of one or more medical conditions. | 02-10-2011 |
| 20090062767 | Combined sensor and infusion set using separated sites - Embodiments of the invention provide a dual insertion set for supplying a fluid to the body of a patient and for monitoring a body characteristic of the patient. Typical embodiments of the invention include a base, an infusion portion coupled to a first piercing member and a sensor portion coupled to a second piercing member. The infusion portion includes a cannula coupled to the piercing member for supplying a fluid to a placement site. The sensor portion includes a sensor coupled to and extending from the base having at least one sensor electrode formed on a substrate and is coupled to the piercing member in a manner that allows the sensor to be inserted at the placement site. The base is arranged to secure the dual insertion set to the skin of a patient. Typically the infusion portion and sensor portion piercing members are arranged such that when they are operatively coupled to the base, they are disposed in a spatial orientation designed to inhibit sensor interference that may be caused by compounds present in fluids infused through the cannula. | 03-05-2009 |
| 20110178498 | Infusion Pump System - Some embodiments of a portable infusion pump system can be configured to can be configured to adjust the sensitivity of particular detectors or alert systems based (at least in part) on information received from a monitoring device. For example, a glucose monitoring device can communication with an infusion pump assembly used to supply insulin or another medication to a user. In such circumstances, the data received from the monitoring device can be used to adjust the sensitivity of an occlusion detection system. | 07-21-2011 |
| 20120245556 | System, Method and Computer Program Product For Adjustment of Insulin Delivery in Diabetes Using Nominal Open-Loop Profiles - A method, system and computer program product for correcting a nominal treatment strategy of a subject with diabetes. The method, system and computer program product may be configured for providing input whereby the input may include: open-loop therapy settings for the subject, data about glycemic state of the subject; and (optionally) data about meals and/or exercise of the subject. The method, system and computer program product may be configured for providing output, whereby the out-put may include an adjustment (correction) to the open-loop therapy settings for the subject for insulin delivery to the subject. | 09-27-2012 |
| 20100057044 | Robust Closed Loop Control And Methods - Methods, system and devices for monitoring a closed loop control operation including signal levels received from an analyte sensor and automatic delivery of medication at least in part in response to the received analyte sensor signals, determining whether the signal level received from the analyte sensor is associated with one of a fault condition or a potential fault condition, and dynamically adjusting a current infusion rate executed by the closed loop control operation when it is determined that the signal level from the analyte sensor is associated with one of the fault condition or potential fault condition, where medication delivery rate is adjusted to a first predetermined range when the signal level is associated with the fault condition, and adjusted to a second predetermined range when the signal level is associated with a potential fault condition, and where the first predetermined range is narrower compared to the second predetermined range are provided. | 03-04-2010 |
| 20090216214 | Therapeutic agent treat to target system - A method of calculating doses of insulin for a person with diabetes and administering the calculated doses to the person with diabetes is presented. Blood glucose values are provided to an insulin dosing calculator which implements a Treat to Target protocol to calculate appropriate doses of insulin. An insulin dispenser is also provided to fill an insulin administration device with the calculated dose. | 08-27-2009 |
| 20100057042 | Closed Loop Control With Improved Alarm Functions - Methods, system and devices for monitoring control parameters in a closed loop control operation including continuously monitoring glucose level and automatic administration of a medication, detecting a condition associated with hypoglycemia, determining whether a probability of the detected condition associated with hypoglycemia exceeding a threshold level, and outputting a notification based upon the determination are provided. | 03-04-2010 |
| 20100057041 | Closed Loop Control With Reference Measurement And Methods Thereof - Methods, system and devices for monitoring a plurality of parameters associated with a closed loop control operation including continuously monitoring a physiological condition and automatic administration of a medication, detecting an impending administration of the medication level exceeding a predetermined threshold level, retrieving one or more signals associated with the monitored physiological condition, determining an accuracy indication of the retrieved one or more signals associated with the monitored physiological condition, and executing the administration of the medication level based on the accuracy indication are provided. | 03-04-2010 |
| 20110251584 | METHOD AND APPARATUS FOR DELIVERING CONTINUOUS INTRAVENOUS INFUSION OF METOPROLOL - A system for automatically providing a continuous flow of metoprolol intravenously to a patient, including a supply of metoprolol solution, a pump connected in fluidic communication with the supply of metoprolol solution, an electronic controller operationally connected to the pump, a vascular access device connected in liquid communication to the pump, and at least one sensor operationally connected to the pump. The pump provides a continuous flow of metoprolol through the vascular access device and the at least one sensor provides data regarding a patient's physical condition to the electronic controller. The electronic controller may control the pump to vary the flow rate of metoprolol in response to data from the at least one sensor and may generate an alarm signal in response to data from the sensor falling outside of predetermined parameters. | 10-13-2011 |
| 20110098674 | Method and System for Programming an Infusion Device - A method of programming an infusion device includes receiving an infusion rate for a time period, wherein the time period overlaps with a predefined start of a predefined period of the infusion device. The time period is converted into (1) a first converted time period extending from a start of the time period to the predefined start of the predefined period, and (2) a second converted time period extending from the predefined start of the predefined period to an end of the time period. The infusion device is programmed with the infusion rate for the first converted time period and the second converted time period. | 04-28-2011 |
| 20110152830 | Systems and methods for managing and delivering patient therapy through electronic drug delivery systems - In example methods and systems described, a medical device can store information locally and in a separate database on a server, for example. If the device fails, or a patient is moved to a second device, information may be transferred to the second device such that the second device can resume a complex therapy at a point where the initial medical device left off. The data necessary to restart the complex therapy system may include certain underlying patient-specific parameters according to a model capturing the patient's physiological response to the medication in question. As a result, it is not necessary for the second device to restart the complex therapy or regress to an initial set of baseline assumptions. | 06-23-2011 |
| 20120203196 | MODULAR EXTERNAL INFUSION DEVICE - A modular external infusion device that controls the rate a fluid is infused into an individual's body, which includes a first module and a second module. More particularly, the first module may be a pumping module that delivers a fluid, such as a medication, to a patient while the second module may be a programming module that allows a user to select pump flow commands. The second module is removably attachable to the first module. | 08-09-2012 |
| 20120302991 | INFUSION PUMP WITH ADD-ON MODULES - This document discusses, among other things, an apparatus comprising a pump configured to deliver a fluid, a wireless communication port, a controller, and a housing to enclose the apparatus. The controller is configured to communicate with a second device via the communication port using an open standard wireless communication protocol. The housing includes a mechanical coupling to slidably engage the second device which includes a second wireless communication port. Slidably engaging the second device positions the first and second communication ports opposite each other to allow communication via the first and second communication ports when slidably engaged. | 11-29-2012 |
| 20110178499 | METHODS TO PAIR A MEDICAL DEVICE AND AT LEAST A REMOTE CONTROLLER FOR SUCH MEDICAL DEVICE - A disease management system, methods, and devices are shown and described. In one embodiment, the system includes an infusion pump and a remote controller with the ability to be paired to each other. A method to verify a wireless connection between an infusion pump and a remote controller is shown and described herein. In a further embodiment, a method to verify a wireless connection between an infusion pump and a remote controller is provided. In addition, a method of operating a diabetes management system is provided in which the system includes an infusion pump and at least a remote controller. | 07-21-2011 |
| 20110257627 | SUBSTANCE MONITORING AND CONTROL IN HUMAN OR ANIMAL BODIES - Diabetes management apparatus comprising a sensor providing measurements of glucose level in a human or animal; an insulin pump for delivering a dose of insulin to said human or animal; and a processor. The processor is adapted to perform the following steps: receive said measurements of glucose level from said sensor; calculate a insulin dose to be delivered by said insulin pump based on said received measurement; assess the validity of the status of the apparatus; and send a command to said insulin pump to deliver said calculated insulin dose, dependent on said assessing step confirming that the status is valid. The insulin pump is configured to deliver a preset dose of insulin unless said processor sends a command to said insulin pump and wherein a said command sent to said insulin pump is valid only for a predetermined time interval so that if no further commands are sent to said insulin pump during said predetermined time interval, said insulin pump reverts to delivering said preset dose of insulin at the end of said predetermined time interval. | 10-20-2011 |
| 20080275423 | METHOD OF MAKING AN ELECTROCHEMICAL SENSOR - A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line. | 11-06-2008 |
| 20100286653 | REMOTE CONTROL DEVICE FOR USE WITH INSULIN INFUSION SYSTEMS - Methods and apparatuses providing accessibility options for the blind and poorly sighted for use with insulin therapy systems. A remote control device, with speech output capability and comprehensive speech menu system, may monitor or intercept data generated by a blood glucose meter, and delay, modify and retransmit said data to an insulin pump. The remote control device may also be used to program and set operating parameters of an insulin pump and also record data received from an insulin pump. The remote control device may also be used in conjunction with a personal computing device. | 11-11-2010 |
| 20100305545 | APPARATUS AND METHOD FOR CONTROLLING INSULIN INFUSION WITH STATE VARIABLE FEEDBACK - An infusion system, which may be a closed loop, or “semi-closed-loop”, infusion system, uses state variable feedback to control the rate at which fluid is infused into a user's body. The closed loop system includes a sensor system, a controller, and a delivery system. The “semi-closed-loop” system further includes prompts that provide indications to the user prior to fluid delivery. The sensor system includes a sensor for monitoring a condition of the user and produces a sensor signal which is representative of the user's condition. The delivery system infuses a fluid into the user at a rate dictated by the commands from the controller. The system may use three state variables, e.g., subcutaneous insulin concentration, plasma insulin concentration, and insulin effect, and corresponding gains, to calculate an additional amount of fluid to be infused with a bolus and to be removed from the basal delivery of the fluid. | 12-02-2010 |
| 20110118699 | Methods and Apparatuses for Selecting a Bolus Delivery Pattern in a Drug Delivery Device - Methods, systems and devices for sustained medical infusion of fluids are described. Some implementations describe portable infusion methods, systems and devices for selecting a pattern of fluid delivery. Some implementations describe skin securable insulin dispensing methods, systems and devices for selecting a delivery pattern according to the nutritional characteristics (e.g. glycemic index, GI, fat content, etc.) of caloric intake of the user. | 05-19-2011 |
| 20110313394 | Sensor Controlled Flow Path For Providing Fluids To Patients - An outflow line is connected to an infusion pump that is programmed to run at a fixed rate. The outflow line has a bypass line that leads from the pump outlet back to the pump inlet. A line downstream of the entrance to the bypass line leads to the patient. The system has two valves. The fluid en route to the patient passes through the first valve. The bypass line passes through the second valve. When one valve is open, the other is closed. The valves' flow states are controlled by a signal from a control instrument. The system allows the pump output to be directed to the patient or to a bypass circuit that returns fluid leaving the pump back to the pump inlet. The system makes it possible to vary the amount of fluid delivered to a patient by an infusion pump set at a constant pumping rate by varying the open and closed state of valves in response to a signal from a patient monitoring instrument. | 12-22-2011 |
| 20110313395 | DRUG DELIVERY MANAGEMENT SYSTEMS AND METHODS - Various embodiments of a “smart” drug delivery pen are provided which include a drug delivery pen having an inertial sensor or accelerometer. A system is also provided that includes the smart drug pen in conjunction with a data management unit(s) DMU. Various exemplary methods for use of the pens and systems are also described and illustrated. | 12-22-2011 |
| 20120232520 | Multi-Function Analyte Monitor Device and Methods of Use - Methods, systems and devices for detecting an analyte sample, determining an analyte concentration associated with the detected analyte sample, storing the determined analyte concentration and a time associated with the determined analyte concentration, retrieving two or more stored analyte concentrations, and determining an adjusted dose level based at least in part on a current dose level and data associated with the two or more retrieved analyte concentrations are provided. For example, adjustments to dosage levels of long-acting insulin may be provided to assist in the management of diabetes and related conditions. | 09-13-2012 |
| 20120004637 | DRUG DELIVERY MANAGEMENT SYSTEMS AND METHODS - Various embodiments of a “smart” drug delivery system are provided which includes an add-on module and a reusable or disposable drug pen in conjunction with a data management unit(s) DMU. Upon attachment to the pen, the add-on module may: determine dosage selected, injection of selected dosage, duration of injection, time of injection, whether the pen has been primed or shaken to thoroughly mix up insulin mixtures, transmit information relating to insulin dosage and injection to a data management unit, provide reminders, error warning or messages on improper usage or reuse of needles, track amount of drug remaining on board the pen or duration of usage of pen with respect to expiry of the drug on board, or provide an audible alarm for locating misplaced pen and module. Methods of using the drug delivery system are also described. | 01-05-2012 |
| 20120209244 | ADHESIVE AND PERIPHERAL SYSTEMS AND METHODS FOR MEDICAL DEVICES - A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems. | 08-16-2012 |
| 20120116347 | THERAPY DELIVERY SYSTEM HAVING AN OPEN ARCHITECTURE AND A METHOD THEREOF - A therapy delivery system having an open architecture and method of providing thereof are disclosed. The present invention provides a therapy dosage module having a control algorithm that can be replaced with a predefined or independently defined control algorithm. The tools necessary to create and test such control algorithms in the therapy dosage module in a simulated environment before implementing it in a live therapy system are also disclosed. | 05-10-2012 |
| 20120010592 | DIABETES CARE MANAGEMENT SYSTEM - A diabetes care management system for managing blood glucose levels associated with diabetes comprising a computing device and an insulin delivery device. The computing device generally includes (i) a memory comprising one or more optimal blood glucose values, one or more self care values of a patient, one or more measured blood glucose values, and one or more scaling factors for weighting the impact on a future blood glucose value and that are customizable to an individual patient to predict the effect on the blood glucose of self care actions performed by the individual patient; (ii) a microprocessor, in communication with the memory, programmed to (A) determine the one or more scaling factors from one or more physiological parameters including body mass, metabolism rate, fitness level or hepatic or peripheral insulin sensitivity, or combinations thereof, and (B) calculate a further value, the further value being based on the self care values, and on the one or more optimal blood glucose values, and on the one or more scaling factors; and (iii) a display configured to display information according to the further value; and (iv) a housing, wherein the memory and the microprocessor are housed within the housing, thereby providing a hand-held, readily transportable computing device. The insulin delivery device may deliver insulin in response to information associated with the further value. | 01-12-2012 |
| 20120022497 | DIABETES MANAGEMENT SYSTEM - A method of diabetes management, comprising (a) providing a glucose meter in communication with a portable microprocessor-based unit; (b) transmitting blood glucose level data into the hand-held microprocessor-based unit from the blood glucose meter; (c) running a program of instructions on the portable microprocessor-based unit or the glucose meter or both; (d) inputting data based upon the blood glucose level data as input data for the program of instructions; and (e) providing a signal to inject insulin when the blood glucose level data indicates. | 01-26-2012 |
| 20120059353 | CGM-Based Prevention of Hypoglycemia Via Hypoglycemia Risk Assessment and Smooth Reduction of Insulin Delivery - An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually. | 03-08-2012 |
| 20110092951 | Method and Apparatus for Cardiac Tissue Monitoring and Catheter-Based Perfusion for Mitigating Acute Reoxygenation Injury - A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes or other ischemic conditions. A method and apparatus is described that allows mitigation of oxygen-related injury by precisely modulating the level of oxygen re-exposure during reoxygenation by a controlled feedback loop based on parameters of the tissue measured by a real-time tissue sensor or probe. | 04-21-2011 |
| 20110106050 | Method for Selecting Bolus Doses and Bolus Delivery Patterns in a Drug Delivery Device - Embodiments of the present disclosure include methods, systems and devices for selecting a bolus configuration and may include one or more of providing a user interface for selection of one or more user interface elements, where each element corresponds to a bolus configuration of a drug, each element is spatially positioned within a multi-dimensional space corresponding to at least three dimensions and the element's position corresponding to each dimension. | 05-05-2011 |
| 20110106049 | FULLY AUTOMATED CONTROL SYSTEM FOR TYPE 1 DIABETES - An augmented, adaptive algorithm utilizing model predictive control (MPC) is developed for closed-loop glucose control in type 1 diabetes. A linear empirical input-output subject model is used with an MPC algorithm to regulate blood glucose online, where the subject model is recursively adapted, and the control signal for delivery of insulin and a counter-regulatory agent such as glucagon is based solely on online glucose concentration measurements. The MPC signal is synthesized by optimizing an augmented objective function that minimizes local insulin accumulation in the subcutaneous depot and control signal aggressiveness, while simultaneously regulating glucose concentration to a preset reference set point. The mathematical formulation governing the subcutaneous accumulation of administered insulin is derived based on nominal temporal values pertaining to the pharmacokinetics (time-course of activity) of insulin in human, in terms of its absorption rate, peak absorption time, and overall time of action. The MPC algorithm is also formulated to provide control action with an integral effect, and in essence minimizes overall drug consumption. When employed as a modulator in an automated integrated glucose-control system for type 1 diabetes, the control algorithm provides the system with self-learning capability that enables it to operate under unrestricted activity of the subject. | 05-05-2011 |
| 20100094251 | Infusion Pump System and Methods - Some embodiments an infusion pump system can be configured to modify alarm limit parameters as the user's insulin load increases or decreases. Moreover, in particular embodiments, the infusion pump system can be configured to provide a “missed bolus” or “missed meal” alarm in response to the user's blood glucose characteristics, the user's insulin load information, or the like. | 04-15-2010 |
| 20120220979 | INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR - Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction. | 08-30-2012 |
| 20120136336 | Closed Loop/Semi-Closed Loop Therapy Modification System - A closed loop/semi-closed loop infusion system provides therapy modification and safeguards against the over-delivery or under-delivery of insulin. A glucose sensor system is configured to obtain a measured blood glucose value. A controller is operationally connected with the glucose sensor system and configured to trigger an alarm based on a measured blood glucose value or amount of insulin delivered, selectively perform calibration of the glucose sensor system when the alarm is triggered, and adjust a therapy delivery parameter when the alarm is triggered, wherein the adjusted therapy delivery parameter is limited to be within a boundary. Thereafter, a delivery system delivers therapy at the adjusted therapy delivery parameter. | 05-31-2012 |
| 20110184380 | SYSTEM AND METHOD FOR PROVIDING CLOSED LOOP INFUSION FORMULATION DELIVERY - A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands. | 07-28-2011 |
| 20100174266 | Infusion Pump System and Methods - Some embodiments an infusion pump system can provide a suggested bolus dosage based on particular parameters (e.g., the user's recent blood glucose characteristics, food intake data, an amount of insulin already delivered to the user which has not yet acted on the user, or other factors). In some circumstances, the infusion pump system can receive information indicative of the user's blood glucose level and suggest an insulin bolus dosage that is at least partially dependent upon the recent rate of change in the user's blood glucose level. Such a feature can be helpful to a user when the infusion pump is operated in conjunction with a glucose monitoring device because the suggested bolus dosage can be at least partially based on recent data indicative of the user's blood glucose level. | 07-08-2010 |
| 20120215201 | INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR - Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction. | 08-23-2012 |
| 20100049164 | Infusion Pump Systems and Methods - Some embodiments an infusion pump system can be used to determine a user's total insulin load (TIL) that provides an accurate indication of the insulin previously delivered to the user's body which has not yet acted. In particular embodiments, the TIL can account for both the bolus deliveries and the basal deliveries that have occurred over a period of time. Such information may be useful, for example, when the infusion pump is operated in conjunction with a continuous glucose monitoring device. | 02-25-2010 |
| 20100274219 | ACQUIRING NERVE ACTIVITY FROM CAROTID BODY AND/OR SINUS - An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and corgestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed. | 10-28-2010 |
| 20100274218 | COMMUNICATIONS FOR MEDICINAL FLUID DELIVERY SYSTEM - Disclosed are methods, devices, systems and computer program products for communicating between at least one unit of a therapeutic fluid dispensing device and at least another unit of the dispensing device. The method includes performing a determination whether a first frequency can be used to transmit a message related to operations of the dispensing device, and transmitting the message based on the determination. | 10-28-2010 |
| 20120232521 | INSULIN PUMP HAVING CORRECTION FACTORS - Methods of regulating blood glucose levels using an insulin pump are disclosed. A method includes receiving a current blood glucose level, and determining whether the current blood glucose level is above a threshold value. The method also includes calculating a correction bolus value based upon the current blood glucose. | 09-13-2012 |
| 20120232519 | Glucagon pump controller - According to a first aspect of the present invention there is provided a controller for controlling a glucagon pump. The controller comprises an input | 09-13-2012 |
| 20080300572 | WIRELESS MONITOR FOR A PERSONAL MEDICAL DEVICE SYSTEM - A monitor device for a fluid infusion system and its operating, display, and data processing characteristics are described herein. One embodiment of the monitor device is used in an insulin infusion system having an insulin infusion pump and a continuous glucose sensor transmitter. The monitor device is configured as a wireless bedside monitor that wirelessly receives status data from a device in the fluid infusion system, such as the infusion pump or the sensor transmitter. The monitor device supports a number of user interface features, alarm/alert features, and graphical display features, where such features enhance the overall operation and user-friendliness of the monitor device. For example, the monitor device can generate status icons that graphically indicate the time remaining for an exhaustible operating quantity of a device in the infusion system (e.g., a battery charge, a fluid reservoir volume, or a calibration or replacement period). The monitor device can also estimate future measurements of a physiological characteristic of a monitored patient, based upon empirical measurement data received by the monitor device. | 12-04-2008 |
| 20120238999 | Infusion Pump Systems and Methods - Some embodiments of an infusion pump system can include a controller in which one or more features sets to be provided by the controller are enabled or disabled based upon the particular pump device that is connected to the controller. For example, in some embodiments, one or more advanced features of the controller are available to the user only when a first type of pump device (e.g., having predefined settings stored therein) is connected to the controller, and those advanced features of the controller are disabled when a second type of pump device is connected to the controller. | 09-20-2012 |
| 20110224646 | Methods and Devices for Tailoring a Bolus Delivery Pattern - Methods and devices for delivering therapeutic fluid to the body are described. The method may include determining a bolus delivery pattern based on a specific dietary intake of a patient and delivering the therapeutic fluid into the patient's body based, at least in part, on the determined bolus delivery pattern. The devices used in conjunction with the disclosed methods may include a controller to determine a bolus delivery pattern based on a specific dietary intake of the patient and an infusion pump to deliver the therapeutic fluid into the patient's body based, at least in part, on the determined bolus delivery pattern. | 09-15-2011 |
| 20120277723 | SYSTEM AND METHOD FOR THE INTEGRATION OF FUSED-DATA HYPOGLYCAEMIA ALARMS INTO CLOSED-LOOP GLYCAEMIC CONTROL SYSTEMS - Methods and systems are described for controlling a flowrate of insulin infused into the body of a patient. An insulin infusion device infuses insulin into the body of the patient. A first sensor generates blood glucose level (BGL) data indicative of a blood glucose level of the patient. A second sensor generates autonomic nervous system (ANS) data such as heart rate data dependent on at least one parameter of the patient's autonomic nervous system. A data fusion processor receives the BGL data and the ANS data and generates an output alarm signal if a hypoglycaemic event is inferred. A flowrate of insulin of the insulin infusion device may be modified dependent on the output alarm signal. | 11-01-2012 |
| 20110276025 | IMPLANTABLE-GLUCOSE RESPONSIVE INSULIN DELIVERY DEVICE - A biocompatible insulin delivery device is provided comprising an insulin reservoir sealed with a glucose-responsive plug or membrane. The plug functions to release insulin from the reservoir in response to a hyperglycemic glucose concentration and to prevent insulin release from the reservoir in response to hypoglycemic glucose concentration. In one embodiment, the plug is made of a biocompatible polymeric matrix comprising an inorganic component, a stimulus-responsive component and a catalytic component. | 11-10-2011 |
| 20120283694 | DEVICES, SYSTEMS AND METHODS FOR QUANTIFYING BOLUS DOSES ACCORDING TO USER PARAMETERS - Devices, systems and methods for determining a recommended bolus dose of therapeutic fluid to be delivered to the body are disclosed. Such a recommended bolus dose may be provided by establishing an initial bolus dose for a user based on one or more first parameters relating to the user and adjusting (e.g., increasing or decreasing) this initial bolus dose amount based on one or more second user parameters by multiplying the initial bolus dose by one or more multiplier values that correlate to at least one of the second parameters and/or by adding or subtracting an absolute value of at least one of the second parameters from the initial bolus dose amount. | 11-08-2012 |
| 20120101474 | MODULAR EXTERNAL INFUSION DEVICE - A modular external infusion device that controls the rate a fluid is infused into an individual's body, which includes a first module and a second module. More particularly, the first module may be a pumping module that delivers a fluid, such as a medication, to a patient while the second module may be a programming module that allows a user to select pump flow commands. The second module is removably attachable to the first module. | 04-26-2012 |
| 20100185175 | SYSTEMS AND METHODS FOR FLUID DELIVERY - A system for at least partial closed-loop control of a medical condition is disclosed. The system includes at least one medical fluid pump. The medical fluid pump including a sensor for determining the volume of fluid pumped by the pump. Also, at least one continuous analyte monitor, and a controller. The controller is in communication with the medical fluid pump and the at least one continuous analyte monitor. The controller includes a processor. The processor includes instructions for delivery of medical fluid based at least on data received from the at least one continuous analyte monitor. | 07-22-2010 |
| 20120150144 | CALCULATING INSULIN ON BOARD FOR AN EXTENDED BOLUS BEING DELIVERED BY AN INSULIN DELIVERY DEVICE - A system and method may be used to calculate insulin on board (IOB) for an extended bolus being delivered by an insulin infusion pump. In general, the system and method calculates an extended bolus IOB value for the extended bolus, which takes into account the insulin currently on board from the extended bolus and the insulin scheduled to be delivered by the extended bolus over a subsequent time period equivalent to a duration of insulin action. The extended bolus IOB value may be used to calculate a suggested bolus. | 06-14-2012 |
| 20110160695 | AMBULATORY INSULIN INFUSION SYSTEM WITH BOLUS ADMINISTRATION DELAY - In one embodiment, an ambulatory insulin infusion system may include an administration module for insulin administration, a data collection module for collecting data relevant for the bolus amount, and a delay module. The administration module may administer insulin continuously according to a basal profile and a bolus on demand. The bolus has a bolus amount. The data collection module may be operatively coupled to the administration module. The delay module may trigger administration of the bolus a therapeutically significant delay interval after the data is collected. | 06-30-2011 |
