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With tubular injection means inserted into body

Subclass of:

604 - Surgery

604019000 - MEANS FOR INTRODUCING OR REMOVING MATERIAL FROM BODY FOR THERAPEUTIC PURPOSES (E.G., MEDICATING, IRRIGATING, ASPIRATING, ETC.)

604020000 - Infrared, visible light, ultraviolet, X-ray or electrical energy applied to body (e.g., iontophoresis, etc.)

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Entries
DocumentTitleDate
20100081987Vacuum-Stabilized Ablation System - Cardiac ablation systems include vacuum-stabilized, irrigated ablation devices that have ablating elements capable of providing regions of relatively low pressure to maintain the ablating element in a stable position relative to the tissue, or minimize relative movement of the ablating element relative to the tissue. The ablation elements have integrated structures for vacuum-stabilization. The devices also include one or more electrodes for both orienting the ablating element as well as for diagnostic purposes.04-01-2010
20090326439HIGH PRESSURE PRE-BURST FOR IMPROVED FLUID DELIVERY - A needle with multiple injection ports is used in connection with a high-pressure injection system to infuse a treatment solution into a treatment area below the dermis of the skin. The needle has multiple tines that extend outwardly from the injection ports while inside the treatment area to disrupt tissue in the treatment area and to create multiple pathways of infusion. The tines are withdrawn and the needle is partially withdrawn, and solution is injected from the needle into the treatment area at high pressure to infuse the tissue within the treatment area. The burst, infusion, and a treatment such as an energy or third solution may be interleaved and repeated multiple times.12-31-2009
20080269665CHEMOTHERAPY DELIVERY DEVICE - A system for delivering medicament to a patient is described. In a first embodiment, the system has a positive ion generator having an input and an output, a device for supplying a medicament, the device in fluid communication with the input, and a nebulizing catheter in fluid communication with the output, the nebulizing catheter configured to receive medicament ionized by the positive ion generator and to deliver the medicament to the patient. In another embodiment, the system has an intracorporeal catheter in fluid communication with the output, the intracorporeal catheter configured to receive medicament ionized by the positive ion generator and to deliver the medicament to the patient. In yet another embodiment, the system has a nebulizing catheter having an input and an output, a device for supplying a medicament, the device in fluid communication with the input, and a positive ion generator in fluid communication with the output, the positive ion generator configured to receive medicament nebulized by the by the nebulizing catheter and to deliver the medicament to the patient.10-30-2008
20130041310Oral Mucosal Electroporation Device and Use Thereof - The present invention relates to electroporation (EP) devices that are able to generate an electroporation causing electrical field at the mucosal layer, and preferably in a tolerable manner. Further, it includes the generation of a protective immune response, cellular and/or humoral, using the oral EP device along with a genetic construct that encodes an immunogenic sequence.02-14-2013
20090043246Magnetic Surgical Device to Manipulate Tissue in Laparoscopic Surgeries Performed with a Single Trocar or Via Natural Orifices - The present invention is related to surgical instruments incorporating the usage of magnets for application in minimally invasive surgery to perform abdominal surgery with a single incision through the navel which is the most widely used, this incision can also be done through some natural orifice like the vagina, mouth, etc.02-12-2009
20090043245DEVICE FOR ADMINISTERING AN INJECTION AND METHOD OF USING SAME - Device for administering an injection is generally discussed herein with particular discussions extended to devices for stimulating a cavity below the skin and administering a dosage in the stimulated cavity and method of using the same. The dosage can be medication for health and/or cosmetic treatments. The device includes a housing and a needle mounted thereto. A vacuum source is in communication with the housing for creating a vacuum inside the housing while a power source is in communication with the needle for supplying current to the needle. The combination current and vacuum stimulates a cavity for injection. A vacuum source may also be used to advance a piston to discharge medicament from a needle mounted on a syringe.02-12-2009
20110009807VARIABLE CURRENT DENSITY SINGLE NEEDLE ELECTROPORATION SYSTEM AND METHOD - This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.01-13-2011
20130072852SYSTEMS AND METHODS FOR TREATING PATHOGENIC INFECTION - An internal anatomic target that is infected by pathogenic microorganisms is treated using an applicator configured for delivering a therapeutic solution thereto and an UV light-emitting device transmits UV light thereon.03-21-2013
20130060188PHOTOCATALYTIC DISINFECTION OF IMPLANTED CATHETERS - An implantable catheter is provided that may be disinfected without removal from the body of a patient, using a photocatalytic method to activate a reaction on the catheter surface that generates oxidizing agents in the form of Reactive Oxygen Species (“ROS”) and thus destroy microorganisms in a biofilm that is present or forming. A catheter system includes the implantable catheter, a light source, and a source of power operably connected to the light source. Methods are also provided for disinfecting the implantable catheter in vivo.03-07-2013
20130102954CURRENT APPLICABLE MULTI-NEEDLE SYRINGE, AND AUTOMATIC INJECTION DEVICE - Disclosed is an electrical signal applicable multi-needle syringe. The present invention comprises: a hollow cylinder; a needle hub closely coupled to the rear end of the cylinder; a plurality of needles placed at regular intervals inside the cylinder in such a way that the front ends are further protruded compared with the front end of the cylinder and the drug which is injected through the needle hub is sucked through the rear ends; a first electrode stored inside the cylinder, and commonly connected to a part of the plurality of needles; and a second electrode stored inside the cylinder, and commonly connected with the rest of the plurality of needles. Therefore, it is possible to inject a drug and to simultaneously apply a high frequency directly into the skin through a multi-needle injected into the skin by applying a high frequency between the first electrode and the second electrode, thereby promoting the activation of the injected drug.04-25-2013
20090259167METHODS AND COMPOSITIONS FOR DOSE-DEPENDENT PHOTODYNAMIC THERAPY OF DISORDERS - The invention provides methods and compositions for treating a tissue disorder in a subject by parenterally administering a solution of aminolevulinic acid (ALA) or a derivative thereof that is not greater than 1.0 percent by weight into a local subcutaneous or dermal region of the subject; and administering high fluence light to said bodily area to produce a phototoxic species in said local region, thereby treating a tissue disorder in the subject.10-15-2009
20080294086Method and apparatus for delivering oxygen and/or other gases to tissue - A system comprising: a hollow tube having a distal end, a proximal end, and a lumen extending between the distal end and the proximal end; at least a portion of the tube comprising a porous membrane; and a gas-rich perfluorocarbon solution incorporated in the porous membrane; wherein the porous membrane has a porosity in the range of 0.001-200 microns, in order that: (i) the gas-rich perfluorocarbon solution is effectively incorporated into the porous membrane; and (ii) when the porous membrane is positioned in blood, the gas-rich perfluorocarbon solution elutes out of the porous membrane, in aggregations small enough to prevent the creation of embolisms in the blood, with the elution of the gas-rich perfluorocarbon solution into the blood varying between minutes and several hours, depending on the temperature and the hemodynamics of the blood.11-27-2008
20080287859Method and Apparatus to Monitor Patients and Treat with Intraosseous Fluids - Automatic external defibrillator apparatus may be provided for use in cooperation with an intraosseous apparatus. Apparatus and methods may also be provided to execute protocols calling for external defibrillation and drug delivery. The disclosure provides a medical apparatus including two electrodes, a processor, a display, a driver, a drug delivery slot, a drug delivery port, and a voltage source. The two electrodes may include an attachment operable to releasably connect the two electrodes to the patient. The processor may be operable to collect and analyze a rhythm associated with the patient's heart from the two electrodes. The display may be operable to communicate instructions to a user. The driver may be operable to insert an intraosseous device into a bone and associated bone marrow of the patient. The drug delivery slot may be operable to receive a drug. The drug delivery port may be operable to communicate the drug from the drug delivery slot to the patient via the intraosseous device. The voltage source may be operable to deliver an electric shock to the patient via the two electrodes.11-20-2008
20090018486Diagnosis and treatment of vericocele and prostate disorders - A method for forestalling or therapy, at least partially, of BPH or prostate cancer comprising identifying a reflux of venous blood to the prostate and impeding the reflux by treating veins effecting or conveying the reflux, and related apparatus and kit.01-15-2009
20090281477ELECTROPORATION DEVICE AND METHOD - Disclosed herein are methods and devices configured for pulsed voltage ablation that have two or more voltage delivery regions separated along a probe by electrically insulating regions. The electrically insulating regions are of sufficient lengths to allow the voltage delivery regions to be oppositely energized for delivering voltage pulses to treat cells within a predetermined ablation volume that can be delineated through representations indicating pulsed voltage ablation thresholds for cells.11-12-2009
20110288469SURGICAL DEVICE AND METHOD FOR PERFORMING COMBINATION REVASCULARIZATION AND THERAPEUTIC SUBSTANCE DELIVERY TO TISSUE - A surgical device is provided for both ablating a channel in a patient's tissue and also delivering a therapeutic agent. The device includes an elongated multi-lumen tube, an elongated tissue ablating assembly, and a therapeutic agent delivery assembly. The therapeutic agent is capable of being delivered into the channel and/or to the surrounding tissue. The device may further include a second multi-lumen tube also capable of delivering therapeutic agents. A method is also provided for using such a surgical device to ablate a channel in a patient's tissue and also deliver a therapeutic agent to the tissue, for example, for transmyocardial revascularization or other procedures.11-24-2011
20110288468DRUG-DELIVERY ACCESSORY FOR AN IMPLANTABLE MEDICAL DEVICE - An implantable drug-delivery sleeve for an elongate component of an implantable medical device. The sleeve includes a tubular substrate having a lumen configured to receive the elongate component so as to allow relative displacement of the substrate and the elongate component, wherein the substrate is shaped so as to be retained stationary at a desired position along the elongate component, and a drug releasably carried by the substrate.11-24-2011
20100191175Thrombolysis Catheter - A thrombolysis catheter apparatus is disclosed comprising: (a) an elongated thrombolysis catheter portion comprising a plurality of independently controllable electroactive polymer actuators, which provide a curvature to the thrombolysis catheter based upon received control signals; (b) a control unit coupled to the plurality of actuators and sending the control signals to the plurality of actuators; and (c) an occlusion removal device. Also disclosed is a method of treating an arterial occlusion by advancing the thrombolysis catheter portion through the arterial vasculature of a patient to a position proximate the occlusion, while controlling the shape of the thrombolysis catheter portion using the control unit. The occlusion is then removed using the occlusion removal device.07-29-2010
20090171265Catheter-Based, Dual Balloon Photopolymerization System - A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes a catheter having a first inflatable member and a guidewire having a second inflatable member. The catheter has an extended tip distal to the first inflatable member that includes multiple perfusion ports. A light emission coil is disposed on the extended tip with individual coil loops interspaced with the perfusion ports. In a method, the guidewire is delivered to a treatment site within a vessel. The catheter is delivered to the treatment site over the guidewire. The inflatable members are inflated to form an enclosed treatment space within the vessel. A photoinitiator is delivered to the enclosed treatment space. Excess photoinitiator is flushed from the treatment space, and a prepolymer is delivered. The prepolymer is cured by light delivered by the light emission coil.07-02-2009
20120089078METHODS AND SYSTEMS FOR TOXIN DELIVERY TO THE NASAL CAVITY - Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.04-12-2012
20090275878Steerable Catheter Device and Method for The Chemoembolization and/or Embolization of Vascular Structures, Tumours and/or Organs - The steerable catheter comprises a flexible tube, inside of which different conducts are arranged: one or more conducts for drug administration, vacuum conducts associated with different radiofrequency electrodes, conducts for the conductive wires that conducts the radiofrequency energy to the distal end of the catheter, conducts for the fibre optic cable/s that conducts the laser energy to the distal end of the catheter, a guiding wire for the catherization, and another components; the steerable catheter being connected from the proximal end to a energy unit and other pressure and/or dosing devices; and the steerable catheter optionally including an inflatable balloon to help occluding the vessel; and it also incorporates one or two electrode/s or conductive layer/s in the distal end of the catheter; the objective of the steerable catheter being the obtaining of better results in the embolization and/or chemoembolization treatments.11-05-2009
20090030365Transdermal Drug Administration Apparatus Having Microneedles - It is intended to provide a transdermal drug administration apparatus having microneedles, which is capable of piercing the skin by a simple procedure in the transdermal administration of a biologically active substance (drug) and allows rapid absorption of the biologically active substance. The present apparatus comprises a microneedle device (01-29-2009
20090005724Device and Method for Delivery of a Physiologically Active Substance Depending on a Measured Physiological Parameter01-01-2009
20100268151Intracranial Implant Emitting Light Between 450 nm and 600 nm - An intracranial implant emitting light having a wavelength between blue and yellow light10-21-2010
20100125238Iontophoretic Therapeutic Agent Delivery System - A system for delivering one or more therapeutic agents contained on or within a delivery segment through a passageway, e.g., a blood vessel, for treatment of a localized region of the passageway, or for treatment of region adjacent to the localized region of the passageway, is provided.05-20-2010
20090287140ELECTRICAL STIMULATION AND INFUSION INTRODUCER ASSEMBLY - An electrical stimulation and infusion introducer assembly is provided for connection to an electrical electrode/electrode. The electrode extends through the lumen of an introducer needle of the introducer assembly. The introducer assembly includes a side port for introduction of liquids through the introducer needle without having to remove the electrode. The side port communicates with the central passageway of the introducer assembly, and the central passageway in turn communicates with the lumen of the needle.11-19-2009
20090299269VASCULAR STIMULATION TO AID INTRAVASCULAR CELL REPLACEMENT THERAPY - A system and method are described involving the use of a cell delivery catheter that incorporates a stimulating electrode to promote vasodilation prior to injection of cells at a target location within a blood vessel. The vasodilation may be produced locally and/or distally from the target location near the target organ. The technique may be applied not only to intra-coronary injection of cells to treat heart disease but to injection of cells in any blood vessel that feeds a target organ.12-03-2009
20080287857Device and method for single-needle in vivo electroporation - Described is a device and method for administration of molecules to tissue in vivo for various medical applications, the device comprising a single-needle electrode which provides for the ability, when the needle is inserted into tissue, such as skin or muscle, to pulse tissue with a non-uniform electric field sufficient to cause reversible poration of cells lying along or in close proximity to the track made by the needle upon its insertion into said tissue11-20-2008
20120143120METHOD AND DEVICE FOR TREATING MICROSCOPIC TUMORS REMAINING IN TISSUES FOLLOWING SURGICAL RESECTION - This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.06-07-2012
20100274178Fluid flowing device and method for tissue diagnosis or therapy - A device and method for safely securing a multilumen device to a tissue, organ or solid tumor within the body of a human during a diagnostic or therapeutic procedure is described. The device is capable of securing the tumor by touching or piercing its surface and providing a coolant to the distal tip. Cooling the tip forms a cryogenically induced region that tightly binds the tip to the tumor, temporarily sealing the entry-track of the instrument. The device further provides at least one injecting/aspirating lumen that can dispense or aspirate a fluid within the tumor, and an outer sheath or guide. Such construction allows injecting part or whole volume of the tumor while the cryogenically induced bond prevents back-flow of the injected substances through the entry-track.10-28-2010
20110208112MEDICAL DEVICE FOR INJECTING LOCAL ANESTHETIC - A medical device for injecting a liquid medicine into an organism. The device comprises a needle, an injection tube attached to the posterior end of the needle and a housing having a conduit at the distal end. The needle being placed inside the housing in such a way that the needle can move from a position where entire length of needle is situated within the housing and the conduit to a position where the needle is protruded out of the housing. The device allows an anesthesia provider to perform a nerve block more safely and efficiently. In one embodiment of the device, an injection pad is used to single handedly inject syringes of liquid medicine into the injection tube.08-25-2011
20090099501Spinal Cord's Epidural Space Detection By Using Fiber Optic Technology - The present invention provides a device and a method for effectively processing epidural anesthesia by providing the needle-localization information in real time. The idea of this invention is derived from the concept that different tissues due to their different composition have different optical properties, such as absorbance and reflection, so we can discriminate the tissue types where the needle reaches by their distinctive optical properties. In this device, the inner solid needle of the puncture needle used before is replaced by a hollow needle which filled with optical fibers, and the distal end of those optical fibers are connected with two light sources of different wavelengths and a light analyzer. Thus, while qualifying and comparing the optical properties of those tissues, these device and method can be very helpful during epidural anesthesia and also reduce the risk of the surgery.04-16-2009
20080319373Compound Delivery Tube - A tube for selective administration of a compound.12-25-2008
20090082714Systems and methods for treating superficial venous malformations like spider veins - Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a light-reactive agent, e.g., verteporfin, at or near an inner wall of a vein. The systems and methods activate the light-reactive agent by applying non-thermal light energy at a wavelength that activates the light-reactive agent to cause localize injury to the inner wall of the vein.03-26-2009
20110144566Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component - Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.06-16-2011
20090099502Microneedle Device And Transdermal Administration Device Provided With Microneedles - The present invention provides a microneedle device having a coating, which is effective even with a low molecular weight active compound and can sustain the effect of the drug for a long period of time, and a transdermal drug administration apparatus with microneedles. The microneedle device (04-16-2009
20090082713METHOD OF ENHANCING IONTOPHORETIC DELIVERY OF A PEPTIDE - The present invention provides methods for the administration of a peptide to a body surface of the patient comprising treating said body surface by microporation and iontophoretically administering the peptide to the body surface. The present invention also encompasses a method of transdermally administering a peptide to the skin of a patient comprising treating the skin with microporation and iontophoretically administering said peptide to the skin. In one embodiment, the body surface or skin is microporated using one or more microneedles.03-26-2009
20090204060Flexible Application Device for the High-Frequency Treatment of Biological Tissue - The invention concerns a flexible application device (08-13-2009
20120078161Apparatus for electrically mediated delivery of therapeutic agents - Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes at least in their deployed state.03-29-2012
20120078163METHOD OF GENERATING CONNECTIVE TISSUE - A method of generating bone or connective tissue in a subject in need thereof, the method comprising: (a) implanting a scaffold in a damaged region of the subject, the scaffold comprising a tissue growth promoting agent; and (b) enhancing uptake of the tissue growth promoting agent into cells located on the scaffold, wherein the enhancing is effected by induced poration of the cells thereby generating bone or connective tissue in the subject. Kits for generating bone or connective tissue are also provided.03-29-2012
20120078162METHOD AND DEVICE FOR ELECTROMOTIVE DELIVERY OF MACROMOLECULES INTO TISSUE - Electromotive delivery of macromolecules can be provided using a delivery device including a first chamber for contacting a macromolecule delivery medium to a surface of a tissue or other anatomy of a patient; and a second chamber for contacting a receiving medium to the patient. A first electrode can be disposed in the first chamber so as to not directly contact the macromolecule delivery medium. A second medium having a buffering agent can be used to keep the first electrode from coming into direct contact with the macromolecule delivery medium. A second electrode can be disposed within the receiving medium in the second chamber such that the second electrode does not directly contact the patient. An electric field can be generated using the first and second electrodes in order to cause the macromolecule delivery medium to move into the tissue of interest from the first chamber of the delivery device.03-29-2012
20130012865CODON-OPTIMZED HEPATITIS B VIRUS CORE ANTIGEN (HBCAG) - A needle device for the delivery of therapeutic material into tissue comprising a connection to a pressure generation element, a lumen adapted for the passage of a therapeutic material, and a needle barrel, wherein each needle barrel comprises an opening adapted to control and deliver a pressure transmitted from the pressure generation element into a tissue to cause an increase in the permeability of a cell membrane to the therapeutic material.01-10-2013
20090254019ELECTRODE INTRODUCER DEVICE - An electroporation device 10-08-2009
20120035530DRUG RELEASING COATINGS FOR MEDICAL DEVICES - The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.02-09-2012
20100174226METHOD AND APPARATUS FOR THE ULTRASONIC CLEANING OF BIOFILM COATED SURFACES - To treat body surfaces, such as the sinuses, which are coated with biofilms, the surface is irrigated and suctioned with a fluid which may contain a biocide or other chemical agent for disrupting the biofilm while ultrasonic energy is applied to the fluid barrier formed over the biofilm. Action of the fluid enhanced by the ultrasonic energy tends to remove sections of biofilm which are suctioned out of the site. An electrical field may also be applied to the biofilm to enhance the disruptive action. Apparatus for practicing this method to treat chronic rhinosinusitis comprises an elongated tube adapted to be inserted into sinus cavities through the nose or mouth. The tube includes a first lumen which feeds an irrigating fluid containing biocides and/or biofilm-disruptive chemicals to the treatment site and a second lumen which suctions fluid from the site. An ultrasound horn extends through the tube and its distal end introduces ultrasonic energy into the fluid layer overlying the biofilm. In an alternative embodiment, the tube includes a pair of electrodes which establish an electric field across the biofilm, accelerating degradation.07-08-2010
20090018487Catheter-Based, Dual Coil Photopolymerization System - A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes an inner catheter received within an outer catheter and a fluid channeling structure mounted on the catheters with its proximal end attached to the outer catheter and its distal end attached to the inner catheter. The fluid channeling structure includes an elastomeric sleeve sandwiched between an inner elastic coil and an outer light emission coil. Light emission coil loops are interspaced with elastic coil loops. The light emission coil has a smaller diameter than the elastic coil, drawing the elastomeric sleeve down between loops of the elastic coil to form a helical channel. The coils and sleeve are stretched to provide a narrowed crossing profile for delivery, and are contracted at a treatment site to form a helical cavity between the sleeve and the vessel wall within which to perform interfacial photopolymerization.01-15-2009
20100191173TREATMENT SYSTEM FOR SURGERY AND CONTROL METHOD OF TREATMENT SYSTEM FOR SURGERY - A treatment system for surgery includes: a handpiece driving apparatus for supplying electric energy to a handpiece, the handpiece including a treatment portion insertable into a body cavity; a perfusion apparatus for perfusing liquid in the body cavity, the perfusion apparatus being capable of adjusting pressure in the body cavity; and a control circuit for controlling the pressure in the body cavity to a different level in conjunction with an output state of the handpiece driving apparatus and changing a flow rate of the perfusion liquid.07-29-2010
20100262069Photodynamic Bone Stabilization Systems and Methods for Reinforcing Bone - Photodynamic bone stabilization systems are disclosed herein. In an embodiment, a photodynamic bone stabilization system includes a catheter having an elongated shaft with a proximal end adapter, a distal end releasably engaging an expandable portion, and a longitudinal axis therebetween; a light-conducting fiber configured to transmit light energy to the expandable portion; a light-sensitive liquid monomer comprising an initiator, wherein the initiator is activated when the light-conducting fiber transmits the light energy to initiate polymerization of the light-sensitive liquid monomer; and a cooling medium configured to control polymerization temperature, wherein the catheter comprises an inner void sufficiently designed to pass the light-sensitive liquid monomer into the expandable portion, and wherein the catheter comprises an inner lumen sufficiently designed to pass the light-conducting fiber into the expandable portion and configured to circulate the cooling medium.10-14-2010
20110238002DEVICE FOR PHOTO-DYNAMIC THERAPY OF A LIVING ORGANISM'S TISSUES - Devices for photo-dynamic therapy of a living organism's tissues comprising an optical light exposure system (I) containing at least one source of light (09-29-2011
20100228182DISSECTION HANDPIECE AND METHOD FOR REDUCING THE APPEARANCE OF CELLULITE - A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.09-09-2010
20090076438Method for treating a sphincter - A method for treating a sphincter provides a polymer material having a liquid state. The method also provides a catheter having a distal end, a tissue piercing device carried by the distal end, and an energy delivery device coupled to the tissue piercing device. The tissue piercing device has a lumen. The method introduces the catheter into an esophagus and pierces an exterior sphincter tissue surface within with the tissue piercing device. The method advances the tissue piercing device into an interior sphincter tissue site and conveys the polymer material while in a liquid state through the lumen into the interior sphincter tissue site. The method delivers energy to the tissue piercing device to transform the polymer material into a less liquid state within the interior sphincter tissue site, to thereby remodel the sphincter.03-19-2009
20100210997Medical Device for Placement of Continuous Regional Anesthesia Catheters - A medical device for placement of regional anesthesia catheters. The device comprises a hollow shaft needle, a plunger attached to the posterior end of the needle, a housing dimensioned so that plunger can slide inside the housing with friction, a regional anesthesia catheter preloaded inside the needle, a protective cover sheath covering the catheter, and a catheter adaptor attached to posterior end of the sheath and the catheter. The medical device allows a practitioner to quickly and effectively place a regional anesthesia catheter inside an organism without the use of an assistant, and with minimal risk of contaminating the catheter before it enters the organism's body. At the end, the needle is withdrawn inside the housing and disposed.08-19-2010
20100125239Selective Drug Delivery In a Lumen - Methods and systems are disclosed for selective drug or fluid delivery in a lumen through a coating or fluid delivery channels. One system includes an elongate catheter having a proximal end and a distal end with an axis therebetween, the catheter having a radially expandable balloon near the distal end and an energy delivery portion proximate the balloon for transmission of energy, a thermally changeable coating having a releasable drug coupled to the balloon, the thermally changeable coating being oriented to be urged against the body tissue when the expandable balloon expands and an energy source operatively coupled to the energy delivery portion configured to energize the energy delivery portion to heat and liquefy the thermally changeable coating to release the drug to the body tissue.05-20-2010
20090287141Device and method for delivering therapeutic agents to an area of the body - A device, system and method deliver an agent to a soft mass, such as an area of the body, and more specifically the brain. One aspect includes creation of one or more channels, tunnels or grooves in tissue using a relatively small diameter, minimally-invasive stylet and then removing the stylet prior to infusion. The stylet-created channels become paths of increased hydraulic conductivity, through which the infusate will tend to flow and produce a predictable infusion pattern. Infusate will be carried into these channels with relatively low resistance, and then infuse outward from these channels into the surrounding tissue. By carefully positioning these channels, one can control and modify the preferred paths and duration of distribution.11-19-2009
20100198135SYSTEMS AND METHODS FOR ANESTHETIZING EAR TISSUE - A system and method for use in iontophoretic anesthesia of a tympanic membrane are disclosed. The system generally includes an earplug and an electrode device. The earplug includes at least one sealing member for sealing the earplug in an ear canal. The sealing member includes microholes which vent fluid above a certain pressure threshold. A headset may connect the earplug to a second earplug. The method involves using the system on a human or animal subject.08-05-2010
20110130709SYSTEMS AND METHODS FOR ELECTRIC FIELD ASSISTED DELIVERY OF THERAPEUTIC AGENTS - Methods of iontophoretically delivering therapeutic agents to diseased tissue, such as for tumor therapy, are disclosed. In one embodiment, the distal end of an endoscopic device is transorally introducing into the gastro-intestinal tract. A delivery element is advanced from the endoscopic device through a wall of the gastro-intestinal tract and into an adjacent pancreas. A therapeutic agent is delivered from the delivery element into the pancreas, an electric field is generated to drive the emitted therapeutic agent into surrounding tissue of the pancreas, causing the emitted agent to penetrate the surrounding tissue.06-02-2011
20090318850LEAKAGE-RESISTANT TISSUE TREATMENT APPARATUS AND METHODS OF USING SAME - Apparatus and methods for treating skin conditions that deliver high frequency energy to a patient's tissue. The apparatus has a treatment tip configured to be removably coupled with a handpiece and a conduit inside the handpiece. The treatment tip includes an electrode configured to deliver the high frequency energy to a region of the tissue, a channel for circulating heat transfer fluid proximate to the electrode, and an inlet passage to the channel. The conduit includes a tubular sidewall with a lumen used to transfer the heat transfer fluid from the handpiece to the inlet passage of the treatment tip. When the treatment tip is coupled to the handpiece, a septum covering the inlet passage is configured to be pierced by the conduit to define an opening for coupling the conduit with the inlet passage. When the treatment tip is removed from the handpiece, the septum substantially seals the opening.12-24-2009
20080287858Microneedle Arrays and Methods of Use Thereof - A method of treating a patient with a microneedle array having an active agent disposed on at least a portion of one or more of the microneedles, wherein the array with active agent is characterized by a first optical response when probed with a selected incident light spectrum. The array with active agent is applied to a skin surface, optionally allowed to remain on the skin surface for a specified time, and removed. The used array is probed with the selected incident light spectrum, a second optical response is sensed, and the difference between the first optical response and the second optical response is determined and compared to a predetermined threshold value.11-20-2008
20100331761Apparatus and Method for Dermatological Wound Healing - A method is provided for treating a dermatological wound. A first step of the method includes providing an iontophoretic apparatus. The iontophoretic apparatus includes at least one surface for contacting a surface of the dermatological wound, a current source electrically coupled to the apparatus, a suction mechanism operably coupled to the apparatus, and a source of therapeutic molecules. A second step of the method includes placing the at least one surface of the iontophoretic apparatus into contact with at least a portion of the dermatological wound surface. A third step of the method includes activating the current source so that a plurality of therapeutic molecules is delivered to the dermatological wound. A fourth step of the method includes activating the suction mechanism to remove fluid and/or debris from the dermatological wound. The second, third, and fourth steps of the method are repeated until the dermatological wound is sufficiently healed.12-30-2010
20110009806MEDICAL DEVICE HAVING ONE OR MORE ACTIVE STRANDS - The present embodiments provide an elongate medical device comprising a plurality of strands twisted in a generally helical manner to form a tubular shape having a longitudinal axis. A first strand of the plurality of strands is moveable with respect to at least a second strand of the plurality of strands. Actuation of the one or more strands may perform a medical function or actuate an associated distal component. A working lumen of the tubular member may remain unobstructed for delivery of medical components or fluids.01-13-2011
20100069824Photodynamic hyperthermic chemotherapy of cancer and therapeutic system therefor - A photodynamic hyperthermic chemotherapy of cancer comprising topically injecting a photosensitive dye agent, specifically indocyanine green, in the form of an acidic liquid formulation to a tumor or cancer tissue, or a surgically removed site thereof of a patient, and irradiating the tissue or site with light having such an output wavelength that the photosensitive dye agent absorbs the light and generates heat; and an apparatus and a system for photodynamic hyperthermic chemotherapy of cancer comprising a light source and a probe having a light introducing portion capable of topically irradiating a tumor or cancer tissue or a surgically removed site thereof of a patient with light derived from the light source by a continuous wave or a pulse wave at an output wavelength of 600 to 1600 nm and an output of 5000 mW or more.03-18-2010
20090043247Method and device for collagen growth stimulation - The invention provides an applicator for skin treatment having one or more RF electrodes. An article is located between the electrodes, such as a roller or flexible belt containing one or more protruding pins electrically isolated from the RF electrodes. The invention also provides a system for skin treatment comprising the applicator of the invention and a control unit. The invention further provides a method of treating skin disorders in which a section of the skin is heated while, essentially simultaneously, piercing one or more holes in the heated section of the skin. The method of the invention may be used, for example, in collagen remodeling.02-12-2009
20110087155TRANSMUCOSAL DRUG DELIVERY DEVICE AND METHOD INCLUDING ELECTRICALLY-ACTUATED PERMEATION ENHANCEMENT - Intralumenal devices and methods are provided for transmucosal drug delivery. The device may comprise a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and an electrically-actuatable portion configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the electrically-actuatable portion.04-14-2011
20100191174HAND-HELD ELECTRICAL STIMULATION DEVICE - Apparatuses and methods for the safe and efficient electrical stimulation of tissue. The apparatuses of the present invention are preferably hand-held and are capable of providing electrical waveforms that are effective in promoting wound healing, improving circulation, stimulating peripheral nerves, administering pharmaceutical compounds via electrophoresis, and electroporating DNA into tissue. The present invention also generally contemplates the safe and efficient transfection of DNA into mammalian tissue via electroporation. Particularly, apparatuses of the present invention are useful in the delivery of DNA vaccines and in gene therapy. The present invention also preferably provides for the direct measurement of in vivo tissue resistance. Tissue resistance measurements may then be used to adjust stimulation intensity during electroporation or electrostimulation, so as to avoid damaging tissue during operation of the unit.07-29-2010
20090312690SELECTIVE PERIPHERAL NERVE PLEXUS IMPLANTABLE INFUSION DEVICE AND METHOD - The present invention relates to a closed system and method for selectively infusing anesthetics into a peripheral nerve or plexus. A method of providing long term pain management is disclosed herein. In the method, a catheter is surgically implanted to create an infusion site at a peripheral neural structure. An implantable pump and reservoir are surgically implanted in subcutaneous tissue. The pump is then operated to deliver a predetermined dosage of medication through the catheter into the infusion site, whereby pain management is provided.12-17-2009
20090036823Fluid flowing device and method for tissue diagnosis or therapy - A device and method for safely securing a multilumen device to a tissue, organ or solid tumor within the body of a human during a diagnostic or therapeutic procedure is described. The device is capable of securing the tumor by touching or piercing its surface and providing a coolant to the distal tip. Cooling the tip forms a cryogenically induced region that tightly binds the tip to the tumor, temporarily sealing the entry-track of the instrument. The device further provides at least one injecting/aspirating lumen that can dispense or aspirate a fluid within the tumor. Such construction allows injecting part or whole volume of the tumor while the cryogenically induced bond prevents back-flow of the injected substances through the entry-track.02-05-2009
20100056985ELECTROACTIVE POLYMER ACTIVATION SYSTEM FOR A MEDICAL DEVICE - An activation circuit for selectively providing an electrical current to one or more electroactive polymers (EAPs) in a medical device is disclosed. The activation circuit may include a sensor for sensing a measure related to a parameter of an elongated member and/or a balloon of the medical device. The electrical current may be provided to the one or more EAPs according to the sensed parameter of the elongated member and/or the balloon of the medical device. In some cases, the activation circuit may include a comparator for comparing the sensed measure to a threshold to determine when the electrical current is applied to the EAPs. The parameter may be a pressure, a fluid flow, a temperature, and/or other suitable parameter.03-04-2010
20090216177CATHETER-TYPE IONTOPHORESIS DEVICE - A catheter-type iontophoresis device is adapted to cause a drug solution to permeate into a cancer site or the like of a digestive organ on a pinpoint basis by iontophoresis.08-27-2009
20110152749EYE INJECTION DEVICE - An injection device for injecting a product into an eye, said device comprising an injection needle and a support on which the injection needle is fixed, said device being characterized in that it comprises a locating mark disposed in such a way that the latter can be placed in contact with a defined bearing region of the surface of the eye, before any contact of the injection needle with said surface, and can then be kept in contact with said bearing region during a stage of penetration of said injection needle through said surface of the eye.06-23-2011
20110251545Cell Reservoirs Created by Polymer Plugs - Described herein generally are catheter systems used to deliver cells and other bioactive materials to a target location within the vascular system of the human body, and methods of delivering cells and other bioactive materials to such target locations.10-13-2011
20110152752Systems, devices, and methods including catheters having components that are actively controllable between transmissive and reflective states - Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.06-23-2011
20100262068Method for creating an autologous radiofrequency capsule for containing filling solutions - A method for creating an autologous radiofrequency capsule for containing filling solutions, whose particularity is that it comprises the combined use of bipolar radiofrequencies and of filling or bio-revitalizing solutions based on hyaluronic acid or similar products.10-14-2010
20100298762Methods and Devices for Improved Efficiency of RNA Delivery to Cells - The instant invention provides a method for improving efficiency of RNA delivery to cells. The method comprises applying a low strength electric field to the cells and then after a certain time period, administering the ribonucleic acid sequence to the cells. Devices, kits, and RNA molecules suitable for delivery and devices suitable for practicing the disclosed methods are also provided.11-25-2010
20110152748Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject - A method for enhancing an immune response in a vertebrate subject is described. The method includes providing at least one energy stimulus configured to modulate one or more nervous system components of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are provided in a combination and in a temporal sequence sufficient to enhance an immune response in the vertebrate subject.06-23-2011
20110152751Systems, devices, and methods including catheters having UV-Energy emitting coatings - Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.06-23-2011
20110152750Systems devices, and methods including catheters configured to monitor and inhibit biofilm formation - Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.06-23-2011
20120277661METHOD AND APPARATUS FOR DELIVERY OF THERAPEUTIC AGENTS - Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a patient. The invention comprises means for the controlled administration of the therapeutic agent through an orifice to the patient, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and means for generating an electrical signal operatively connected to the electrodes.11-01-2012
20080214986GELS WITH PREDETERMINED CONDUCTIVITY USED IN ELECTROPORATION OF TISSUE - Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.09-04-2008
20110264030DELIVERY APPARATUS AND ASSOCIATED METHOD - A delivery apparatus for delivering a cargo to a target site of internal body tissue is provided. The delivery apparatus comprises a flexible tubular member having a distal end adapted for insertion proximate to the target site. A first electrode is configured for insertion within the flexible tubular member such that the first electrode is capable of being disposed proximate to the target site. A second electrode is configured to cooperate with the first electrode to form an electric field. A delivery component has a cargo carried thereby and is coupled with the first electrode. The delivery component is configured to degrade when exposed to the electric field such that the cargo is released to the target site upon degradation thereof. An associated method is also provided.10-27-2011
20110125081Drug delivery apparatus guided by Micro Electrical Field Network for target cell of liver - A drug delivery apparatus guided by micro electrical field network for target cells of liver comprises a low-voltage micro- electrical field generator and a drug delivery catheter which gets into a liver through an endoscope or indwelling catheter along blood vessels, wherein at least two drug infusion holes and a first array of electrodes are provided at the front end of the drug delivery catheter; a second array of electrodes is set on the exterior of the liver; the first array of electrodes and the second array of electrodes are connected with the pulse output terminal of the low-voltage micro-electrical field generator; the drug delivery catheter is connected through with a drug transportation device.05-26-2011
20110130708Directional Delivery of Energy and Bioactives - Systems and methods are disclosed for the treatment of a target tissue by directionally delivering energy and/or bioactive materials to achieve a therapeutic effect. A balloon catheter system having a balloon portion and a plurality of electrodes may be energized to selectively deliver energy, bioactive materials, or a combination thereof to target tissue including tissues disposed about a lumen. The tissue may be targeted by applying energy, making tissue impedance analysis, and further selectively energizing electrodes through the use of an energy source with a controller.06-02-2011
20100174225DRUG DELIVERY DEVICE - The present disclosure presents systems, devices and methods for injection of drugs, substances and/or chemicals to a patient and for improving their effectiveness once they are injected are disclosed. Additional treatment can be applied to a tissue region on the patient into which a drug (e.g., insulin) is injected, to expose the tissue region to various forms of energy or a substance to improve the drug's pharmacokinetic and/or pharmacodynamic profile.07-08-2010
20100121256Implantable and Refillable Drug Delivery Reservoir - Implantable drug delivery apparatuses and methods are described. An input port septum receives a therapeutic drug. An implantable delivery catheter holds a volume of the therapeutic drug and includes a proximal end in fluid communication with the input port septum, a distal end including an output septum for removing fluid from the catheter, and a drug permeable surface for diffusion of the therapeutic drug into nearby tissue.05-13-2010
20110190689INTRAVAGINAL THERAPY DEVICE - An intravaginal treatment device (ITD) provides therapeutic light and fluid treatments. Vision systems throughout supporting networks and devices allow for directed control of the treatment processes. The ITD uses illumination to gather various types of imager data that is used to identify and conditions, monitor the treatment process, and evaluate treatment efficacy. Specific frequency light emissions and associated fluids are used to reduce overabundant flora, at least assist in elimination of fungal, viral and bacterial invaders, and enhance the detection process. Several configurations and sizes of ITDs with light and fluid therapy, also have a built in optics assembly (camera, light sources, etc.) for capturing intravaginal still images and video of vaginal channels, cervix, cervical channels, uterus and fallopian tubes. Some ITD configurations are also wearable and include full fluid delivery infrastructure unlike some other ITDs with external components. Supporting devices include local and remotely located computing devices such as laptops, smart phones, and independent monitors. ITDs can be fully or partially inserted via the vaginal channel, and operate in a stand-alone mode or pursuant to remote control. Therapy procedures may be preset or programmed to deliver continuous, periodic and scheduled performance with various underlying parameters defined in the preset or programming processes.08-04-2011
20100280433PROSTATE GLAND ELECTROCHEMICAL-THERAPEUTIC DEVICE - A prostate gland electrochemical-therapeutic device is provided. The prostate gland electrochemical-therapeutic device includes a probe unit and an electrode unit. The probe unit is adapted for introducing a saline solution into a patient's prostate gland. The electrode unit then conducts an electrochemical reaction on the saline solution introduced in the prostate gland to generate a strong acid solution and/or a strong alkaline solution for curing the prostate gland thereby.11-04-2010
20100030131SYSTEMS AND METHODS FOR ANESTHETIZING EAR TISSUE - A system and method for use in iontophoretic anesthesia of a tympanic membrane are disclosed. The system generally includes an earplug and an electrode device. The earplug includes at least one sealing member for sealing the earplug in an ear canal. The method involves using the system on a human or animal subject.02-04-2010
20110118656Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject - A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more sheaths configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more applicators supported by the one or more sheaths and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.05-19-2011
20130012867METHODS AND APPARATUS FOR PERFORMING A NON-CONTINUOUS CIRCUMFERENTIAL TREATMENT OF A BODY LUMEN - Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.01-10-2013
20130012866APPARATUSES FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS - Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.01-10-2013
20080269666Microneedles and Methods for Microinfusion - Methods and devices are provided for delivering a drug to or withdrawing a fluid from a biological tissue, such the skin, sclera, cornea, and conjunctiva. One method includes the steps of inserting at least one microneedle into the biological tissue; partially retracting the at least one microneedle from the tissue; and then delivering at least one drug formulation into the biological tissue via the partially retracted at least one microneedle. The microneedle deforms and penetrates the biological tissue during the insertion step, and the retraction step at least partially relaxes the tissue deformation while maintaining at least part of the tissue penetration, facilitating drug delivery or fluid withdrawal.10-30-2008
20090088680OPTICAL TISSUE INTERFACE METHOD AND APPARATUS FOR STIMULATING CELLS - In one example, a system electrically stimulates target cells of a living animal using an elongated structure, a modulation circuit and a light pathway such as provided by an optical fiber arrangement. The elongated structure is for insertion into a narrow passageway in the animal such that an end of the elongated structure is sufficiently near the target cells to deliver stimulation thereto. The modulation circuit is for modulating the target cells while the elongated structure is in the narrow passageway, where the modulation circuit is adapted to deliver viral vectors through the elongated structure for expressing light responsive proteins in the target cells. The light pathway is used for stimulating the target cells by delivering light to the light-responsive proteins in the target cells.04-02-2009
20120059308PERIPHERAL NERVE BLOCK CATHETER - An anesthetic nerve block catheter and methods of using the anesthetic nerve block catheter to perform a nerve block or continuous nerve block procedure are disclosed.03-08-2012
20120016291ROBOTICALLY CONTROLLED INTRAVASCULAR TISSUE INJECTION SYSTEM - A robotic catheter system includes a controller including a master input device and instrument driver in communication with the controller. An elongate flexible guide instrument is operatively coupled to the instrument driver. A fluid injection needle may be advanced from, or retracted into, a distal portion of the guide instrument.01-19-2012
20110092884Device for Skin Treatment - Disclosed herein is a device for skin treatment, which precisely transmits high-frequency energy to a target portion of skin tissue without causing a burn on the outer layer of the skin, thus artificially damaging the portion and inducing a wound curing reaction, therefore leading to the regeneration of skin and the propagation of collagen. The device prevents the surface of skin from suffering an injury during insertion, alleviates pain, and keeps the depth to which the needle is inserted into the skin uniform. The device includes a plurality of needles coated with an insulator except for sharp ends. A needle holding unit holds the needles. A drive unit directly or indirectly transmits a force to the needle holding unit, thus allowing the needles to be inserted into the skin. An electromagnetic wave transmitting unit is electrically connected to the needles and transmits electromagnetic waves to the needles.04-21-2011
20110092883TRANSDERMAL DRUG ADMINISTRATION APPARATUS AND TRANSDERMAL DRUG ADMINISTRATION UNIT - According to one embodiment, a transdermal drug administration apparatus includes a first member having a protrusion on a facing surface opposed to a skin and a guide hole in the protrusion and a second member having a needle portion located in the guide hole and movable in a first direction across a surface of the skin.04-21-2011
20090131855APPARATUS AND METHODS FOR DRUG RELEASE IN TISSUE ABLATION PROCEDURES - Tissue ablation probes and methods for treating tissue are provided. The tissue ablation probe comprises an elongated probe shaft, at least one electrode carried by the distal end of the probe shaft, and a pharmaceutical agent carried by the probe shaft. The pharmaceutical agent may be disposed on the electrode(s), the probe shaft, or a releasable portion associated with the electrode or the probe shaft. A method for treating tissue comprises introducing a tissue ablation probe to a tissue site, operating the tissue ablation probe to ablate tissue at the tissue site, and releasing a pharmaceutical agent from the tissue ablation probe at the tissue site.05-21-2009
20090131854Methods and Devices for Thermally Degrading Bacteria and Biofilm - Described herein are various implantable devices that include a heat generating element for degrading bacterial. In particular, the device can include a catheter having a heat generating element proximate to a distal end of the catheter for heating an outer surface of the catheter.05-21-2009
20100204640MEDICAL DEVICE, IN PARTICULAR FOR ELECTROPORATION TREATMENT - A medical device, in particular for electroporation treatment, characterized by having: 08-12-2010
20100204639DIAGNOSIS AND TREATMENT OF VARICOCELE AND PROSTATE DISORDERS - A method for forestalling or therapy, at least partially, of BPH or prostate cancer comprising identifying a reflux of venous blood to the prostate and impeding the reflux by treating veins effecting or conveying the reflux, and related apparatus and kit.08-12-2010
20090030364Electroporation gene therapy gun system - A cartridge for administration of a bioactive agent may include a plurality of chambers, including at least a first chamber and a second chamber. Each of the chambers may contain a component of a composition to be administered to a tissue site of a subject. For example, the first chamber may contain the bioactive agent and the second chamber may contain a liquid for suspending the bioactive agent prior to administration to the tissue site. An apparatus for administering or delivering a bioactive agent may include the cartridge and may further include an energy source for providing an electrical pulse to the tissue site. The apparatus may further cause mixing of the bioactive agent with the liquid in the cartridge. For example, the apparatus may impact the cartridge to result in mixing of the bioactive agent with the liquid. A method for combining a bioactive agent with a liquid forms a composition for delivering to a tissue site.01-29-2009
20120316488Method and Devices for Treating Atrial Fibrillation by Mass Ablation - Apparatus and method for ablating target tissue including a non-linear area of tissue in the left atrium of a patient. The method can include selecting an ablation apparatus having an ablator with a tissue engagement section, penetrating a chest cavity of the patient, and identifying the target tissue. The method can also include positioning the ablation apparatus adjacent to the target tissue so that the tissue engagement section can transfer ablation energy to the target tissue. The method can further include energizing the tissue engagement section with ablation energy in order to create a footprint on the non-linear area of tissue in the left atrium and to reduce an overall mass of excitable tissue in the left atrium.12-13-2012
20120316489METHOD AND SYSTEM FOR TREATING CANCER - A method and system for treating cancer of a patient are disclosed. In a first aspect, the method comprises injecting bleomycin into the patient and administering excorporeal ultrasound to a localized area of the cancer, wherein the bleomycin more readily enters the localized area to treat the cancer of the patient. In a second aspect, the system comprises an injection unit for injecting bleomycin into the patient and an ultrasound module for administering excorporeal ultrasound to a localized area of the cancer, wherein the bleomycin more readily enters the localized area to treat the cancer of the patient.12-13-2012
20120259269IONTOPHORESIS DRUG DELIVERY SYSTEM AND METHOD FOR DENERVATION OF THE RENAL SYMPATHETIC NERVE AND IONTOPHORETIC DRUG DELIVERY - A system for denervation of the renal sympathetic nerve and iontophoresis drug delivery includes an iontophoresis catheter fitted with a drug coated balloon. The balloon contacts the vessel wall when inflated. One or more electrodes are associated with a surface of the balloon, and may be disposed on an outer surface of the balloon. The electrodes are operably coupled to an energy source configured to produce a bipolar or monopolar electric field between two balloon electrodes and/or between one balloon electrode and another electrode placed in contact with the patient's body. The drug-delivery catheter produces an electric potential gradient within adjacent tissue, that, facilitates iontophoresis delivery of a drug. The catheter can also include a store of one or more drugs to be delivered to the targeted tissue.10-11-2012
20120259268PHOTODYNAMIC THERAPY FOR TUMORS WITH LOCALIZED DELIVERY - Methods and systems for treatment of hypoxic tumors are provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering an oxygenating agent to the tumor tissue via the delivery device and radiating the tumor tissue with radiation. Methods and systems of treatment of tumors are also provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering a photosensitizing agent to the tumor tissue via the delivery device, and radiating the tumor tissue with light.10-11-2012
20100331762Refillable Reservoir Lead Systems - Medical electrical lead systems and related methods are described. The medical electrical lead systems may be configured to be at least partially implanted in a body of a subject. Some variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and a lumen extending at least partially therebetween, at least one electrode in the proximity of the distal end of the lead body, and a reservoir in fluid communication with the lumen, where the reservoir is located at a position removed from the distal end of the lead body. Certain variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and first and second lumens extending at least partially therebetween, and at least one electrode in the proximity of the distal end of the lead body.12-30-2010
20080300530STIMULATING CATHETER - An apparatus for delivery of a substance to an anatomical region in a body can include a catheter comprising a catheter body, and one or more electrically conductive elements supported by the catheter body and in electrical communication with one or more sources of electrical stimulus. The catheter body can comprise a lumen therein, a substantially closed distal end, and an infusion section configured to permit fluid to pass through the catheter body and that can have a length that is less than or equal to the length of the catheter body. In some embodiments, the apparatus can comprise a coiled member positioned within the lumen of the catheter body. The coiled member can comprise adjacent coils and can permit the uniform flow of the substance through one or more holes formed in the catheter body.12-04-2008
20120238945Device for Actively Removing a Target Cell from Blood or Lymph of a Vertebrate Subject - Devices, systems, and methods are described herein for controlling the level of one or more target cell types in the blood fluid and/or lymph fluid of a vertebrate subject. Devices, systems, and methods are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to the at least one lumen; one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; at least one reactive component disposed in the at least one treatment region; and at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen.09-20-2012
20120238944Device for Actively Removing a Target Cell from Blood or Lymph of a Vertebrate Subject - Devices, systems, and methods are described herein for controlling the level of one or more target cell types in the blood fluid and/or lymph fluid of a vertebrate subject. Devices, systems, and methods are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to the at least one lumen; one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; at least one reactive component disposed in the at least one treatment region; and at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen.09-20-2012
20120238943METHODS OF ELECTRIC FIELD INDUCED DELIVERY OF COMPOUNDS, COMPOSITIONS USED IN DELIVERY, AND SYSTEMS OF DELIVERY - In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of delivering a compound, a composition, and the like.09-20-2012
20110046540Apparatus for Trans-Cerebral Electrophoresis and Methods of Use Thereof - The present invention provides apparatus and methods for the delivery of therapeutic agents to target tissues by electromigration. The utilization of electric fields according to the methods of the invention aids in the distribution and targeting of therapeutic agents, in particular, where standard means of agent application in the target tissue is insufficient to achieve prophylactic or therapeutic results. In particular embodiments, the present invention utilizes a convective force in combination with the developed electric fields to further increase the flux of the therapeutic agent or to further improve distribution of the therapeutic agent within the target tissues.02-24-2011
20110160644Systems, devices, and methods including catheters configured to release ultraviolet energy absorbing agents - Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.06-30-2011
20110160643Systems, devices, and methods including catheters having acoustically actuatable waveguide components for delivering a sterilizing stimulus to a region proximate a surface of the catheter - Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.06-30-2011
20110160642PEGYLATED LIPOSOMAL FORMULATIONS FOR PHOTODYNAMIC TREATMENT OF INFLAMMATORY DISEASES - A PDT treatment system designed to treat all types of human inflammatory disorders. A suitable drug delivery system is developed to target proliferating cells, at inflamed sites, populated with macrophages and other inflammatory mediators. The hydrophobic photosensitizer is loaded into the liposomal bilayer formed of synthetic phospholipids; at least one of the synthetic phospholipids is conjugated to polyethylene glycol (PEG) molecules, to prevent accumulation in the liver and spleen. Further, (PEG) formulated photosensitizer increases the circulatory half-life of the drug, enhances solubility, and modifies pharmacokinetic and pharmacodynamic properties. The formulation, thus, leads to a higher amount of delivered drug to the diseased target synovial tissue, increasing clinical effectiveness. In one embodiment, pegylated liposomes loaded with mTHPC are administered to diseased synovial joints, followed by light irradiation. Activated photosensitizer induces cytotoxic effect in the diseased synovial cells, thus preventing further inflammation and joint erosion and minimizing joint damage.06-30-2011
20120289888Irreversible Electroporation and Tissue Regeneration - A method and device are herein described to treat a target region of tissue, using at least one energy delivery device coupled to a power source and positioned in a treatment position so as to irreversibly electroporate tissue to ablate a target region, and introduce regenerative materials into a treated region.11-15-2012
20110319809CATHETER DEVICE FOR DELIVERY ENERGY TO A VEIN - The present disclosure relates to devices, systems, and methods associated with a catheter device for delivering energy to a vein. One or more catheter devices include a cooling device, an infusion device, and an energy delivery device for delivering energy to a vein to treat incompetent valves.12-29-2011
20100168647NON-CONTACT ELECTRODE BASKET CATHETERS WITH IRRIGATION - Catheter systems and methods are disclosed. An exemplary catheter includes an outer tubing housing and an inner fluid delivery tubing, the inner fluid delivery tubing having at least one fluid delivery port. The catheter also includes a deployment member movable axially within the inner fluid delivery tubing. A plurality of splines are each connected at a proximal end to the outer tubing and at a distal end to deployment member. A seal is provided between the outer tubing and the inner fluid delivery tubing. A gasket is provided between the deployment member and the inner fluid delivery tubing. Both the seal and the gasket are configured to prevent blood or other fluid from ingressing into the outer tubing.07-01-2010
20100130912Patches and methods for the transdermal delivery of a therapeutically effective amount of iron - Embodiments of the invention provide patches for the transdermal delivery of iron-containing compositions to an individual suffering from an iron deficiency. Many embodiments provide an iontophoretic patch for the transdermal delivery of a therapeutically effective amount of iron. The patch comprises an electrode and a reservoir containing a composition comprising ionic iron for the delivery of the therapeutically effective amount of iron. Various embodiments provide methods of using embodiments of the iontophoretic patch for delivering a therapeutically effective amount of iron to an individual suffering from one more forms of iron deficiency including iron deficiency anemia. Such methods can be used for treating and/or preventing the iron deficiency. The amount of delivered iron can be adjusted depending upon various treatment parameters such as patient weight and type and amount of iron deficiency.05-27-2010
20100130913INTEGRATED CATHETER AND PULSE GENERATOR SYSTEMS AND METHODS - Disclosed herein, among other things, is a system for providing pacing during revascularization. An embodiment of the system includes an angioplasty or stent delivery catheter system having a catheter, a balloon and an inflation device adapted to inflate and deflate the balloon for delivery of a stent. The embodiment also includes a programmable pulse generator and at least one electrode integrated with the angioplasty catheter system, where the pulse generator is connected to the electrode. In various embodiments, at least one integrated sensor is connected to the angioplasty catheter system. The sensor is adapted to sense a parameter indicative of flow restoration and trigger the pulse generator to begin pacing based on the parameter.05-27-2010
20110264029IONTOPHORETIC DELIVERY SYSTEM - Methods, systems and other embodiments associated with administering ionotophoretic medicines are presented. A method of administering ionotophoretic medicines includes applying a voltage across a body tissue and an iontophoretic solution including medicine. At least some of the iontophoretic solution including medicine is then injected into the body tissue without requiring the iontophoretic transportation of the iontophoretic solution including medicine through the skin. The iontophoretic solution is typically injected while the voltage is applied. The voltage causes an ionic current of iontophoretic medicine to flow which disperses the medicine within the body tissue toward body tissue connected to the voltage.10-27-2011
20130178788ELECTROOSMOTIC CONVECTION-ENHANCED DELIVERY SYSTEM - Apparatuses and methods for electrokinetic transport of fluids to patients. Drug-containing solutions may be placed in vial-like reservoir, which is connected to an apparatus such as a traditional catheter or other device capable of holding a drug-containing solution. Instead of a vial-like reservoir, a doped infusion pad or a gel may be used as a source of the drug-containing solution. The reservoir and apparatus may thus be the same component. The methods and apparatuses disclosed herein may also be used to transport fluid alone to achieve a clinical effect. The apparatus is placed at the point of drug delivery. The counter-electrode may be placed in or on a patient. Current is passed from the reservoir to the counter-electrode. Through electrokinetic transport, drug-containing solution is delivered along a current path from the drug source to the counter-electrode. A hollow fiber catheter for use in electrokinetic transport is also disclosed.07-11-2013
20080214988Methods And Devices For Fractional Ablation Of Tissue - Methods and devices for ablating portions of a tissue volume with electromagnetic radiation (EMR) to produce lattices of EMR-treated ablation islets in the tissue are disclosed, including lattices of micro-holes, micro-grooves, and other structures. Also, methods and devices for using the ablated islets are disclosed, including to deliver chromophores, filler, drugs and other substances to the tissue volume.09-04-2008
20080214987Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances - A system and method of using a high-aspect ratio microdevice for treating, preventing or ameliorating a medical condition is provided.09-04-2008
20100030130PHARMACEUTICAL INTERVENTION FOR MODULATION OF NEURAL PLASTICITY - A stimulating medical device. The stimulating medical device comprises: a stimulating assembly implantable proximate to a recipient's neural system, the assembly having at least one agent delivery port and a plurality of electrical contacts; an electrical stimulation controller configured to generate electrical stimulation signals for application the neural system via one or more of the plurality of electrical contacts; a pharmaceutical agent source configured to provide a plasticity modulating agent to the at least one delivery port for application to the neural system; and a pharmaceutical agent controller configured to control one or more of the pharmaceutical agent source and the at least one delivery port to cause selective application of the plasticity modulating agent to the neural system to at least one of reinforce and activate one or more neural pathways within the system.02-04-2010
20100318020ELECTROCHEMICAL THERAPEUTIC AGENT DELIVERY DEVICE - A therapeutic agent delivery device and method for eluting a therapeutic agent to a target location are disclosed. The device may comprise a first conductive element, a second conductive element, an electrochemical composition including an electrolyte and a therapeutic agent, and a permeable membrane covering the electrochemical composition. The first conductive element and the second conductive element are adapted to be connected to a voltage source. When the voltage source is connected to the first conductive element and the second conductive element, an electrochemical reaction occurs causing the therapeutic agent to pass through the permeable membrane and thereby to elute to a target location.12-16-2010
20100318019ELECTROPHYSIOLOGY DEVICES EMPLOYING ELECTRICALLY CONDUCTIVE POLYMER CONDUCTORS AND METHODS OF MANUFACTURING SUCH DEVICES - A medical tubular body that may be used in an implantable medical lead, a catheter, a sheath and introducer is disclosed herein. The medical tubular body may include a tubular layer formed of an electrically insulating polymer and an electrically conductive polymer strip imbedded in and longitudinally extending through the insulating polymer.12-16-2010
20130197426SYSTEMS AND METHODS FOR ANESTHETIZING EAR TISSUE - A system and method for use in iontophoretic anesthesia of a tympanic membrane are disclosed. The system generally includes an earplug and an electrode device. The earplug includes at least one sealing member for sealing the earplug in an ear canal. The method involves using the system on a human or animal subject.08-01-2013

Patent applications in class With tubular injection means inserted into body