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Infrared, visible light, ultraviolet, X-ray or electrical energy applied to body (e.g., iontophoresis, etc.)

Subclass of:

604 - Surgery

604019000 - MEANS FOR INTRODUCING OR REMOVING MATERIAL FROM BODY FOR THERAPEUTIC PURPOSES (E.G., MEDICATING, IRRIGATING, ASPIRATING, ETC.)

Patent class list (only not empty are listed)

Deeper subclasses:

Class / Patent application numberDescriptionNumber of patent applications / Date published
604021000 With tubular injection means inserted into body 126
Entries
DocumentTitleDate
20130030354SYSTEMS, METHODS, AND DEVICES FOR IN VIVO DELIVERY USING REMOTE ACTUATION OF IMPLANTABLE HYDROGEL MEMS DEVICES - MicroElectroMechanical System (MEMS) devices can be fabricated completely of hydrogel materials. Such hydrogels can include polyethylene glycol with diacrylate functional groups (e.g., PEGDA), which are photopolymerizable in the presence of crosslinkers and photoinitiators. By using PEGDA monomers of different molecular weights and at different percentages, the mechanical properties of the polymerized gels and their respective permeabilities can be tuned. This spatial variation in properties and permeabilities can lead to different functionalities between different portions of the hydrogel MEMS device. Portions of the hydrogel device may be remotely actuated by applying wave energy, for example, a magnetic field, high intensity focused ultrasound, and/or infrared radiation. The remote actuation can allow the device to be actuated in vivo, for example, to allow the device to deliver a drug or other substance at a desired time and/or desired location within a patient.01-31-2013
20130030353NEUROMODULATION TRANSFECTION SYSTEM WITH PASSIVE FLUID DELIVERY - An implantable optical electrode having a thin film electrode array including a plurality of electrodes, a light source associated with the thin film electrode array, and a passive bioactive agent delivery module associated with the thin film electrode array. Also disclosed are methods of manufacturing the array and a neural interface system with passive fluid delivery.01-31-2013
20130030352NEUROMODULATION TRANSFECTION SYSTEM WITH ACTIVE FLUID DELIVERY - A neural interface array including an optical waveguide, a thin film electrode array associated with the optical waveguide, the thin film electrode array having a plurality of electrodes, and a fluid delivery channel attached to at least one of the optical waveguide and the thin film electrode array. Also disclosed are methods for optical stimulation and a neural interface system with active fluid delivery.01-31-2013
20100010418ELECTRICALLY ACTIVATED GEL ARRAY FOR TRANSDERMAL DRUG DELIVERY - A transdermal drug delivery system (01-14-2010
20100160849Methods for Identifying Areas of a Subject's Skin that Appear to Lack Volume - The present embodiments relate to methods and systems for identifying areas of a subject's skin that lack sufficient volume. In some embodiments, this can be used to direct the administration of filler compositions or the application of techniques that increase the volume or firmness of the area. In some embodiments, the methods and systems provide for improved aesthetic benefit as well as suitability for instruction and training. In some embodiments, the methods are especially useful in the administration of dermal fillers to a subject.06-24-2010
20100056983Treatment of cancer using photodynamic therapy - A method for treatment of cancerous tissue in the upper respiratory system including the steps of: injecting HPPH in a physiologically compatible medium into a patient having the cancerous tissue at a level of 3 through 5 mg/m03-04-2010
20100152644METHOD AND DEVICE FOR DRUG DELIVERY - Systems, devices and methods for delivery of a chemical substance to the body of the patient are provided. Such embodiments may include an infusion catheter configured to be inserted into tissue, a catheter securing element configured to be adhered to the skin of the patient and further configured to secure the infusion catheter to the skin, a drug delivery pump configured to infuse a drug into the infusion catheter for delivery to a drug infused region on the body of the patient, and a treatment element configured to apply a treatment to the drug infused region to improve pharmacodynamics of the drug during a period of delivery of the drug to the patient.06-17-2010
20110196285Hollow Mesoporous Silica Sphere Coated with Gold and Preparation Method Thereof and Use in Cancer Therapy - The present invention relates to the preparation method of a hollow mesoporous silica sphere coated with gold shell and its use in tumor therapy. In the present invention, the hollow mesoporous silica sphere is made as core and its surface is uniformly coated with the gold shell. The antitumor medicine is loaded in the hollow mesoporous silica sphere and the tumor specific targeting agent is coupled with the surface of the gold shell. The particle size of the hollow mesoporous silica sphere and the thickness of the gold shell are controllable. Based on the Mie Scattering Theory, the hollow mesoporous silica sphere coated with gold shell can adjust its absorption in near-infrared area and convert the light energy of infrared laser into peripheral heat which can kill the malignant tumor cells. The hollow mesoporous silica sphere can be used as a carrier for sustained/controlled release of therapeutic medicine, and the tumor specific targeting agent coupled with the surface of the gold shell can make the medicine have the function of targeting.08-11-2011
20110196284SYSTEMS AND METHODS FOR DETECTION OF WOUND FLUID BLOOD AND APPLICATION OF PHOTOTHERAPY IN CONJUNCTION WITH REDUCED PRESSURE WOUND TREATMENT SYSTEM - Wound fluid blood detection systems and methods are described that are operable in conjunction with reduced pressure wound treatment (RPWT) systems, as well as ancillary therapy and monitoring systems applied concurrently with RPWT systems. The blood detection monitor operates by optically characterizing the content of wound fluids to the extent of identifying percentage blood content. This identification relies upon the transmission of select wavelengths of light across a volume of wound fluid to a photo detector (connected to signal processing instrumentation) capable of quantifying the absorption characteristics of the fluid. The detection components may be implemented in conjunction with either a fluid flow conduit (i.e. the reduced pressure tubing directing fluid away from the wound dressing) or more directly in association with the materials that comprise the wound dressing positioned within the wound bed itself. In addition, the present invention is configured to operate in conjunction with blood gas monitoring, systems operating with the RPWT. Finally, the components of the systems that serve to illuminate the wound bed, lend themselves to use in conjunction with illumination in discreet electromagnetic wave wavelengths suitable for the application of phototherapy.08-11-2011
20110196283METHODS AND ARCHITECTURE FOR POWER OPTIMIZATION OF IONTOPHORETIC TRANSDERMAL DRUG DELIVERY - Embodiments of the invention provide an architecture, system and methods for optimizing power utilization for transdermal iontophoretic drug delivery which maintain a iontophoretic driving voltage at a reduced or even minimum value to support an iontophoretic delivery current. The reduced voltage reduces the power requirements for a transdermal iontohoretic delivery system during a period of drug delivery. Embodiments of an architecture for implementing this approach can utilize a controller which compares the desired current to the actual current and adjusts the voltage to reduce the amount of power used for iontophoretic drug delivery. The controller can comprise a state machine or microprocessor. Embodiments of the invention are particularly useful for extending the battery life of transdermal iontophoretic drug delivery systems.08-11-2011
20100049117Microporator for Porating a Biological Membrane and Integrated Permeant Administering System - A micro-porator (02-25-2010
20090099499INTELLIGENT SEQUENTIAL ILLUMINATING DEVICE FOR PHOTODYNAMIC THERAPY - Intelligent sequential illuminating device for photodynamic therapy of surface tumors that comprises: the module for illumination and detection, module for signal processing and control and module for power supply, of which the module for illumination and detection consists of the violet light emitting diodes (04-16-2009
20100130908METHOD OF USE OF PORPHYRINS IN PREPARING A MEDICAMENT FOR SONODYNAMIC THERAPY AND A METHOD OF SONODYNAMIC THERAPY USING PORPHYRINS - The invention provides method of use of a porphyrin compound as shown below in preparing a medicament for sonodynamic therapy, and a method of sonodynamic therapy using a porphyrin compound. Said therapy comprises administering a porphyrin compound to a patient and applying sonic wave to the patient,05-27-2010
20100076367IONTOPHORETIC DEVICE - The invention relates to an iontophoretic device for the enhanced transport of substances through the skin (03-25-2010
20120245507PHARMACOKINETICS OF IONTOPHORETIC SUMATRIPTAN ADMINISTRATION - Improved pharmacokinetic profiles for the iontophoretic delivery of sumatriptan are described.09-27-2012
20100160850GELS WITH PREDETERMINED CONDUCTIVITY USED IN ELECTROPORATION OF TISSUE - Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.06-24-2010
20130035629OPTICAL BANDAGE TO STERILIZE WOUNDS - A pad is provided that supplies light to a composite layer, which may be provided on a wound. The composite layer may include a combination including a form of collagen and a chromophore that releases a reactive oxygen species upon exposure to the light. The reactive oxygen species may then act to kill bacteria or other microorganisms in the wound.02-07-2013
20130035630Aptamer for the Capture, Diagnosis, Enumeration, and Eradication of Circulating Tumor Cells - Aptamers for use in the capture, diagnosis, enumeration and eradication of circulating tumor cells; an aptamer immobilized microfluidic chips for use in a rapid and non-invasive method of testing for cancer by capturing and detecting circulating tumor cells through the use of the aptamers immobilized microfluidic chips, and screening high risk patients for cancer thereby allowing the disease to be identified at the early stage where the prognosis of survival is the highest; and a non-invasive method of treating cancer by capturing and eradicating circulating tumor cells through the use of aptamer-photosensitizer conjugates injected into a patient's bloodstream and excited by a laser.02-07-2013
20090054828Systems for transient conduction control - The invention provides a system coupled to a heart having a right atrium (RA) and an atrioventricular (AV) node, which includes an implantable gene regulatory signal delivery device configured to deliver a light to a target site in the heart to transiently control an aberrant cardiac electrical conduction, the light having characteristics suitable for regulating a transcription control element; and an implantable medical device communicatively coupled to the implantable gene regulatory signal delivery device, the implantable medical device including: an atrial fibrillation (AF) detector configured to detect AF; and a control circuit configured to initiate an emission of the light from the implantable gene regulatory signal delivery device in response to the detection of AF. Also provided are methods to transiently control aberrant AV conduction or transiently control cardiac arrhythmias, which employ expression cassettes.02-26-2009
20100145257METHOD, APPARATUS, AND KIT FOR ONYCHOMYCOSIS TREATMENT - Methods, apparatus, and kits for onychomycosis treatment are presented. In one embodiment, a kit for treatment includes an anti-fungal agent, in a composition, and an electrically powered patch. Exemplary embodiments of the patch include a first electrode, a power source having a first and second terminal, a second electrode coupled to the second terminal of the power source, and a base member supporting the first electrode, the second electrode, and the power source. Embodiments include those where the first and second electrode and power source are printed on the base member. Anti-fungal agents may be unionized while the composition includes an ionizing agent. Home use may be practiced, as embodiments include those in which the voltage or current of the power source cannot be adjusted by a user. Exemplary methods include the selection of a nail or diseased area to which treatment is desired and administering the kit as described.06-10-2010
20100145255System And Method For Reducing The Appearance Of Fine Lines And Wrinkles And Improving the Skin Tone - The present invention provides a system for rejuvenating the skin, reducing the appearance of fine lines and wrinkles, and improving the skin tone, which includes both a topical composition and a phototherapy device. Specifically, the topical composition contains one or more skin rejuvenating agents selected from the group consisting of creatine, adenosine phosphate, acetyl carnitine, acetyl hexapeptide, and combinations thereof in a pharmaceutically or cosmetically acceptable carrier. The phototherapy device contains one or more light emitting diodes (LEDs) for emitting electromagnetic radiation effective for energizing the skin cells and enhancing skin absorption of the skin rejuvenating agents. More particularly, the topical composition is capable of transmitting at least 80% of the electromagnetic radiation emitted by the phototherapy device to the skin.06-10-2010
20100145254Systems and Methods for Treatment of Prostatic Tissue - A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe transurethrally. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Another feature of the prostate therapy system is that it can aspirate tissue from the prostate. Yet another feature of the prostate therapy system is that it can rotate during delivery of vapor and aspiration of tissue. Methods associated with use of the prostate therapy system are also covered.06-10-2010
20100145253METHODS FOR NON-THERMAL APPLICATION OF GAS PLASMA TO LIVING TISSUE - Method for the non-thermal treatment of human or animal tissue with high-voltage electrical discharge plasma is disclosed. The disclosed method employs current through plasma and through tissue not for the purpose of heating the tissue, but instead to maintain the plasma proximate to the tissue being treated. Also disclosed is a method of limiting the current through plasma and through tissue to minimize tissue heating by placement of an insulator or semiconductor between an electrode and tissue resulting in generation of a high-voltage discharge similar to a dielectric barrier discharge. The disclosed non-thermal plasma treatment can be employed to promote coagulation of blood, sterilization, disinfection, re-connection of tissue, and treatment of tissue disorders without causing significant thermal tissue damage.06-10-2010
20130041309APPARATUS AND METHOD FOR PERFORMING RADIATION ENERGY TREATMENTS - Method to apply photo-stimulation, photo-dynamic therapy and/or ablation laser treatment to biological tissue including directing radiation from at least one radiation energy source for supplying a treatment radiation; adjusting a collimator assembly for directing radiation from the at least one radiation energy source to the treatment site; collecting radiation not absorbed at the treatment site and reflecting the radiation back to the treatment site, while a contact surface of the collector is engaged with the surface of the biomass; maintaining a set distance between the adjustable collimator assembly and the contact surface; and moving a lens relative to an outlet aperture of the adjustable collimator assembly when the collector is adjusted to thereby produce a given spot size, shape or energy density of the treatment radiation emitted from the adjustable head assembly.02-14-2013
20130041308Laser Assisted Nail Avulsion - A method of treating inaccessible microbial infections, the method comprising the steps of exposing the microbe, irradiating the microbe with infrared radiation and cooling such that heat inactivates the pathogen and stimulates a wound healing response in the patient.02-14-2013
20130041307APPLICATION OF BETA-FUNCTIONALIZED DIHYDROXY-CHLORINS FOR PDT - The present invention provides methods to obtain biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders. An embodiment of the present invention consists of a method to synthesize diketo-chlorins as precursors. In yet another embodiment these precursors are converted to β-functionalized hydroxy- and dihydroxy-chlorins. Another embodiment is to provide amphiphilic compounds with a higher membrane affinity and increased PDT-efficacy. Another embodiment consists of the formulation of the desired isomer into a liposomal formulation to be injected avoiding undesirable effects like precipitation at the injection site or delayed pharmacokinetics of the tetrapyrrole systems.02-14-2013
20090270788MICROCURRENT-GENERATING TOPICAL OR COSMETIC SYSTEMS, AND METHODS OF MAKING AND USING THE SAME - The present invention relates to a topical or cosmetic system that includes a first element capable of acting as an electron donor and a second element capable of acting as an electron acceptor. Such first and second elements are spaced apart by a predetermined distance across a skin surface. The system also includes a third element extending over the predetermined distance across the skin surface, while the third element contains an electrically conductive medium for electrically connecting the first and second elements, thereby generating an electrical current that flows across the skin surface from the first element through the conductive medium to the second element in the absence of any power source. The present invention also relates to methods of using the above-described system for preventing or treating skin damage.10-29-2009
20100042040SYSTEM, DEVICE AND METHOD FOR THE ANTIBACTERIAL AND FUNGICIDE TREATMENT OF A HUMAN OR ANIMAL BODY - The invention relates to a system, a device, and a method for the antibacterial treatment of a patient, using a combination of light and dye. The invention is characterised in that the maximum intensity of the light is at a wavelength which is different to the wavelength of a maximum absorption of the dye. Such a device can be used to obtain especially good bactericide and/or fungicide results.02-18-2010
20090156981Flexible Catheter for High-Frequency Therapy of Biological Tissue and Method of Using Same - A catheter for the high-frequency therapy of body lumens has a flexible shaft tube (06-18-2009
20100106077Methods, Compositions and Apparatus for Treating a Scalp - A phototherapy light cap is a flexible, generally hemispherical cap having a light source to supply suitable dosage requirements of current and future light therapies. The phototherapy light cap may also include a rechargeable battery source, a light source or an array of light sources, a light diffuser and an interface to a recharging source that may be a docking station. A phototherapy light cap may alternatively be an insert for any commercial head dressing, preferably adapted for convenient recharging. Combining the use of a phototherapy light cap with gelatinized therapeutic agents provides a suitable treatment technique for a scalp utilizing phototherapy, heat and any suitable combination of active ingredients such as minoxidil.04-29-2010
20100106075Method for iontophoretic fluid delivery - A method is provided for low cost, accurate, iontophoretic fluid delivery. The method includes providing an electronic circuit coupling a plurality of electrodes, charging a chargeable electromotive cell to a selected potential and/or charge in response to a selected quantity of beneficial agent to be delivered, the chargeable electromotive cell being electronically coupled with the electronic circuit, applying the selected quantity of beneficial agent to at least one electrode, placing the at least one electrode in contact with skin, and delivering the selected quantity of beneficial agent. The method may also include preparing the skin using a skin preparation device in order to enhance the delivery of the beneficial agent.04-29-2010
20100106076DRUG ADMINISTRATION BASED ON A PATIENT'S ACTIVITY STATUS MEASURED BY ACCELERATION SENSORS - It is described a drug delivery system (04-29-2010
20100106074PHYSICAL, STRUCTURAL, MECHANICAL, ELECTRICAL AND ELECTROMECHANICAL FEATURES FOR USE IN ASSOCIATION WITH ELECTRICALLY ASSISTED DELIVERY DEVICES AND SYSTEMS - Provided are various embodiments of integrated electrode devices, assemblies and systems structured for use in association with electrically assisted delivery devices configured for delivery of a composition to a membrane. The integrated electrode devices, assemblies and systems include one or more of a variety of structural, physical, mechanical, electrical and electromechanical enhancements.04-29-2010
20090192438Use of Iontophoresis or Electrotherapy and Ultrasound to Deliver Melanin for Skin Rejuvenation - The method disclosed includes the combining of iontophoresis or electrotherapy and ultrasound to simultaneously deliver the appropriate chromophore to the skin for cosmetic or therapeutic treatment of the skin and skin conditions by the use of a laser, Intense Pulsed Light (IPL), a combination of laser and Radio Frequency (RF) energy, or a combination of IPL and RF.07-30-2009
20090124958DEVICE AND METHODS FOR TREATMENT OF TISSUE - A device and methods for treating tissue via laser energy to induce tissue reduction and/or necrosis are described herein. Laser energy may be applied to a tissue region via an optical fiber advanced through a lumen of at least one needle. Fluid may also be infused or injected into the tissue region through at least one needle. Tissue reduction and/or necrosis of a target tissue region in turn reduces the appearance of droopy, baggy and/or wrinkled skin.05-14-2009
20090124957Method of Producing an Ion-Exchange for Iontophoresis - A method of producing an ion-exchange membrane for iontophoresis by preparing a polymerizable composition containing monomer components and non-polymerizable components which are compatible with the monomer components but do not copolymerize therewith; forming the polymerizable composition into a membrane form; polymerizing the polymerizable composition in the obtained membrane form to thereby form a membrane of a structure in which the non-polymerizable components are dispersed in the polymer having a crosslinked structure; removing the non-polymerizable components from the obtained membrane; and, as required, introducing ion-exchange groups into the polymer. The ion-exchange membrane obtained by the above method is applied to an iontophoresis device. When an ionic medicine contained in a medicine-containing portion of the device is permeated into a living body by the electrophoresis through the ion-exchange membrane, not only ionic medicines having small formula weights but also medicinal ions of formula weights of about 500 to about 1,000 can be efficiently administered into the living body.05-14-2009
20120184895TREATING BACTERIA WITH ELECTRIC FIELDS - Cells that are in the process division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like bacteria, but does not harm normal cells that are not dividing. Since the vulnerability of the dividing cells is strongly related to the alignment between the long axis of the dividing cells and the lines of force of the electric field, improved results can be obtained when the field is sequentially imposed in different directions.07-19-2012
20120184894Patches and Methods for the Transdermal Delivery of Agents to Treat Hair Loss - Embodiments of the invention provide patches for the transdermal delivery of compositions to treat an individual suffering from hair loss. Many embodiments provide an iontophoretic patch for the transdermal delivery hair growth stimulating agents for the treatment of hair loss by stimulating the growth of new hair in areas of the scalp exhibiting hair loss. The patch comprises an electrode and a reservoir containing a composition comprising iron containing compound, such as a chelated iron compound for the delivery of the therapeutically effective amount of iron. The patch can be shaped to be placed and remain on the head. Various embodiments provide methods of using embodiments of the iontophoretic patch for delivering a hair growth stimulating agent such as a chelated iron compound, minoxidil and finasteride to the scalp and other areas exhibiting hair loss. Such methods can be used for re-growing hair, and/or preventing or slowing hair loss.07-19-2012
20090005721PACKAGED IONTOPHORESIS SYSTEM - Provided is a packaged iontophoresis system 01-01-2009
20100069823Iontophoresis-based medical device - An iontophoresis-based medical device includes a positive electrode section, a negative electrode section, a power source supplying an electric current to the positive electrode section and negative electrode section and a controller controlling the current value and conduction time of the electric current, wherein a writing brush is electrically connected to the positive electrode section, and a sponge is electrically connected to the negative electrode section, and the writing brush is formed of a large number of long soft hairs and a large number of short soft hairs such that the writing brush has a columnar shape at a base portion thereof and is gradually tapered toward a tip portion thereof from a middle portion thereof and the tip portion is made extremely fine to form an acute apex thus allowing the apex to touch an affected part in a pinpoint manner.03-18-2010
20130046227Devices and Methods for Recording Information on a Subject's Body - Embodiments disclosed herein relate to methods, devices, and computer systems thereof for visibly or non-visibly indicating a subject has received a medical treatment. In certain embodiments, a subject receives an information mark in conjunction with a medical treatment. In certain embodiments, the information mark includes unique information relating to the subject. In certain embodiments, the information mark is fluorescent or phosphorescent. In certain embodiments, the information mark includes one or more magnetic particles. In certain embodiments, the information mark includes a combination of magnetic particles, fluorescent particles, phosphorescent particles, and/or multi-spectral ink. In certain embodiments, devices, computer systems, and methods relate to reading an information mark on a subject, and optionally determining if further medical treatment of the subject is warranted. In certain embodiments, receipt of an information mark entitles a subject to a reward.02-21-2013
20130090592USE OF AMINOLEVULINIC ACID AND DERIVATIVES THEREOF - The invention provides the use of a photosensitiser which is 5-aminolevulinic acid (5-ALA) or a derivative (e.g. an ester) of 5-ALA, or a pharmaceutically acceptable salt thereof, in the manufacture of a composition for use in methods of photodynamic therapy (PDT) on an animal, wherein said PDT comprises: (a) administering to said animal a composition comprising said photosensitiser; and (b) photoactivating said photosensitiser, and wherein side-effects (e.g. pain and/or erythema) of said PDT are prevented or reduced by use of one or more of (i)-(iv): (i) said composition comprises said photosensitiser in a concentration of less than 10% wt (e.g. 0.5 to 8% wt), (ii) said composition is administered for less than 2 hours (e.g. 30 minutes to 90 minutes) prior to said photoactivation, (iii) said photoactivation is carried out with a light source having a fluence rate of less than 50 mW/cm04-11-2013
20130090591LOCALIZATION OF AGENTS AT A TARGET SITE WITH A COMPOSITION AND AN ENERGY SOURCE - A method for localizing delivery of an agent to a target site in a subject is provided. The method allows accumulation and/or release of the agent at the target site in the subject through the use of an energy source.04-11-2013
20110009805RING ELECTRODE ASSEMBLY AND APPLICATIONS THEREOF - A pair of electrodes having a concentric arrangement and a medium. One of the pair of electrodes known as the delivery electrode (typically the inner electrode), is coupled to an electrical current source. The other electrode, known as the floater electrode is electrically isolated from the delivery electrode. The medium is directly or otherwise electrically coupled to one of the electrodes.01-13-2011
20110009804Method and System for Delivering a Medicant - The present disclosure provides a method for administering chemotherapy to a patient. The method includes heating target tissue to a first temperature to cause hyperthermia, wherein the temperature is in the range of about 40° C. to about 45° C. The method includes allowing the body to compensate for the hyperthermia by causing hyperfusion and increased blood flow to the target tissue. The method includes administering a chemotherapeutic drug adjacent the target tissue and allowing the chemotherapeutic drug to perfuse the target tissue; and heating tissue to a second temperature to ablate the target tissue.01-13-2011
20090306579DELIVERY OF CORTICOSTEROIDS THROUGH IONTOPHORESIS - Disclosed herein are formulations of dexamethasone or a prodrug thereof suitable for delivery by ocular iontophoresis and methods of use thereof.12-10-2009
20090306578Artificial receptors - Antibodies are provided. For as example, an antibody capable of binding an artificial receptor which comprises a hydroquinone monolayer and is incapable of binding the artificial receptor when comprising a benzoquinone monolayer. Also provided are methods and systems using same for control delivery of a molecule-of-interest into a tissue.12-10-2009
20090306577SONIC APPLICATOR FOR SKIN FORMULATIONS - The applicator includes a housing and a motor contained therewithin which includes an output member, such as a shaft, which in operation moves in a reciprocating manner. A contact member is mounted for operation and moves in response to the action of the output shaft, such that the contact element in operation repeatedly contacts a selected skin area, moving toward and away from the skin area, substantially perpendicularly thereto. The contact member moves at a frequency within the range of 50 Hz to 200 Hz and with an amplitude of 0.010 to 0.075 inches. The repeated tapping action of the contact member against the skin increases the absorption of a skin formulation into the skin area being contacted.12-10-2009
20090306576System for Transmembrane Administration of a Permeant and Method for Administering a Permeant - A system for transmembrane administration of a permeant, the system comprising: a) at least one permeant (12-10-2009
20090118662Drug delivery devices - A drug delivery device for delivering a drug to a preselected treatment site, includes a rupturable film capsule enclosing a quantity of the drug to be delivered; an array of micro-needles formed with passageways therethrough carried by the device; a covering layer overlying the capsule and forming a fluid-tight seal with the perimeter of the micro-needle array such that when the device is located with the micro-needles facing the treatment site, the application of pressure to the device causes the micro-needles to penetrate the treatment site and the capsule film to rupture to deliver the drug via the passageways to the treatment site; and an open mesh layer adjacent to the array of micro-needles effective, upon rupture of the capsule film, to uniformly distribute the drug to the micro-needles and also to reduce the possibility of clogging of the passageways.05-07-2009
20090093749APPARATUS AND METHOD FOR SKIN TREATMENT - A device for treatment of skin tissue includes RF electrodes for applying RF energy to the skin and a dispensing unit for dispensing a depilatory substance onto the skin. The device may include a housing, an RF electrode assembly including RF electrodes for applying RF energy to the skin, one or more of the RF electrodes is movable relative to the housing and to the surface of the skin for distributing the RF energy to various parts of the skin and for spreading the depilatory substance along the surface of the skin. The RF electrodes are energized by an internal or external RF energy source. A method for treatment of skin tissue includes applying a depilatory substance to the skin and applying RF energy to the depilatory substance treated skin.04-09-2009
20130072849USE OF GREEN PORPHYRINS TO TREAT NEOVASCULATURE IN THE EYE - Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions.03-21-2013
20130072850TISSUE TREATMENT SYSTEMS AND METHODS HAVING A NON-TACTILE-STIMULUS-ACTIVATED, MACROSCOPICALLY-DEFORMING MATERIAL - A system for treating a tissue site of a patient includes a dressing filler adapted to be positioned at the tissue site. The dressing filler includes a base and a plurality of nodes extending from the base. The base further includes a plurality of openings disposed in the base. At least one of the plurality of nodes is comprised of a non-tactile-stimulus-activated, macroscopically-deforming (NTSAMD) material.03-21-2013
20130072851Therapeutic Micro-Current Delivery Devices And Methods Thereof - A therapeutic micro-current delivery device includes a first electrode in electrical contact with a user at a first user location, a second electrode in electrical contact with the user at a second user location, a power source operable to provide a first voltage potential at the first electrode and a second voltage potential at the second electrode, and a micro-current control circuit in electrical communication with the first electrode, second electrode and power source. Electrical contact of the first electrode at the first user location and electrical contact of the second electrode at the second user location completes an electrical circuit. The micro-current control circuit generates a micro-current I03-21-2013
20110060268NAIL TREATMENT DEVICE - Provided is a nail treatment device including an active delivery device for disposing on the nail and for promoting delivery of an active agent into the nail to treat a nail infection; and at least one means for preventing delivery of the active agent to the skin. Further provided is a method of treating a nail infection including applying onto an infected nail a nail treatment device including an active delivery device for promoting delivery of an active agent into the nail to treat a nail infection and at least one means for preventing delivery of the active agent to the skin.03-10-2011
20110060266ENHANCED STEM CELL THERAPY AND STEM CELL PRODUCTION THROUGH THE ADMINISTRATION OF LOW LEVEL LIGHT ENERGY - Methods of enhancing stem cell therapy through the administration of low level light energy are provided in several embodiments. Some embodiments comprise irradiating stem cells before or after implantation at a target tissue having loss of function due to damage or disease, with a resultant increase in the efficacy of the cell therapy. In some embodiments, light energy enhances one or more of the viability, proliferation, migration or engraftment of the stem cells, thereby enhancing the therapeutic effects of the irradiated cells during cell therapy.03-10-2011
20110015560Wound irrigation containment arrangement - A containment arrangement for safely and effectively treating a wound on a patient without contaminating attending personnel. The arrangement comprises a patient receiving first enclosure having a patient contacting periphery, a pressurizable source in communication with the patient through a wall of the enclosure for enlarging the enclosure, and a sealing means arranged in the patient contacting periphery. A hand manipulable fluid discharge nozzle is extendably arranged through the enclosure for providing controllable treatment fluid to the wound on the patient within the enclosure.01-20-2011
20130060187SYSTEMS AND METHODS FOR CORNEAL CROSS-LINKING WITH PULSED LIGHT - A method for controlling activation of Riboflavin applied to an eye includes applying the Riboflavin to a selected region of a cornea of the eye and initiating cross-linking activity in the selected region by activating the Riboflavin with pulsed light illumination. The pulsed light illumination has an irradiance, dose, and an on/off duty cycle. The irradiance, the dose, and the on/off duty cycle are adjusted in response to a determination of photochemical kinetic pathways for Riboflavin cross-linking activity and to control photochemical efficiency.03-07-2013
20090270787SYSTEMS AND METHODS FOR CREATING ENLARGED MIGRATION CHANNELS FOR THERAPEUTIC AGENTS WITHIN THE ENDOTHELIUM - A system for enlarging endothelium migration channels at a treatment site in a coronary vessel wall, to enable enhanced delivery of a therapeutic agent thereto. The system includes an enlarging agent, for enlarging endothelium migration channels at a treatment site in a coronary vessel wall. It also includes a delivery system, for delivering the enlarging agent to the treatment site, so that the enlarging agent will be delivered thereby to enlarge the endothelium migration channels at the treatment site, and for delivering the therapeutic agent to the delivery site. The therapeutic agent will thereby be delivered into the enlarged migration channels at the treatment site, to treat the treatment site with the therapeutic agent.10-29-2009
20120226217PHOTOSENSITIZING COMPOSITIONS - The invention relates to pharmaceutically acceptable salts of amphiphilic photosensitizing agents which have a water solubility of at least 0.5 mg/ml and to their use in methods of photochemical internalization. Such salts may be formed from a pharmaceutically acceptable base, for example an organic amine such as an amino alcohol, or from a pharmaceutically acceptable acid, for example a sulphonic acid or a sulphonic acid derivative. Due to their increased water solubility, such salts are particularly suitable for use in the preparation of parenteral pharmaceutical preparations, e.g. for use as solutions for injection or infusion.09-06-2012
20130165844METHODS FOR MODULATING CELL FUNCTION - Methods for modulating nerve function are disclosed. An example method for modulating nerve function may include providing a transgene including a neuron-specific promoter and a gene encoding a light-sensitive protein, delivering the transgene to a body tissue including one or more target neurons, implanting a light source adjacent to the cell bodies of the one or more target neurons, and emitting light from the light source. Light may be exposed to the cell bodies of the one or more target neurons and may cause a conformational change in the light-sensitive protein.06-27-2013
20130066255IONTOPHORETIC PATCH WITH SIDE TAB - The present disclosure relates to an iontophoretic device having a delivery portion and a control portion that are located on a common base layer but separated from one another so as to provide increased flexibility and interface with a wearer.03-14-2013
20130066256Treatment of Acne Using Derivatives of 5-Aminolevulinic Acid - The invention provides use of a photosensitiser, which is a derivative (e.g., an ester) of 5-aminolevulinic acid (5-ALA) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the prevention or treatment of acne.03-14-2013
20110021970NON-INVASIVE ENERGY UPCONVERSION METHODS AND SYSTEMS FOR IN-SITU PHOTOBIOMODULATION - Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ01-27-2011
20130102952IONTOPHORETIC AND ELECTROOSMOTIC DISC TREATMENT - Apparatus for treating a body of a subject is provided. The apparatus includes (04-25-2013
20130102953Nano Mixed Metal Oxide Thin Film Photocatalyst Consisting Of Titanium, Indium and Tin - The present invention relates to a novel photocatalyst comprising Nano mixed metal oxides of titanium, Indium and tin as a thin film with nano sized grains, method of its preparation and applications. The photocatalyst disclosed herein can be used in oxygenation of human/mammalian blood along with all other applications of photocatalysts. A photocatalytic oxygenator for the oxygenation derives oxygen from the water content of mammalian blood. The photocatalyst disclosed herein can also be used for effluent treatments along with all other applications associated with photocatalysts.04-25-2013
20090264809METHOD AND APPARATUS OF LOW STRENGH ELECTRIC FIELD NETWORK-MEDIATED DELNERY OF DRUG, GENE, SIRNA, SHRN, PROTEIN, PEPTIDE, ANTIBODY OR OTHER BIOMEDICAL AND THERAPEUTIC MOLECULES AND REAGENTS IN SKIN, SOFT TISSUE, JOINTS AND BONE - The illustrated embodiments of the invention include four preferred embodiments: 1) a method and apparatus for the joint and its related soft tissue for bone gene, protein and drug delivery; 2) a method and apparatus for gene, protein and drug delivery to an extremity; 3) a method and apparatus for delivery of gene, protein and drug delivery to skin and soft tissue; and/or 4) a method and apparatus for delivery of a gene, protein and drug to soft tissue tumor.10-22-2009
20120197179PHOTOTHERAPY DEVICES AND METHODS COMPRISING OPTIONALLY SUBSTITUTED TERPHENYL AND QUATERPHENYL COMPOUNDS - Methods and devices related to the treatment of diseases using phototherapy are described. Some embodiments provide an organic light-emitting diode device, such as a light-emitting device for phototherapy, comprising Ring system 1, Ring system 2, Ring system 3, or Ring system 4. Methods of treating disease with phototherapy are also described.08-02-2012
20100121253Method and Apparatus of Low Strength Electric Field Network-Mediated Delivery of Drug, Gene, SI-RNA, SH-RNA Protein, Peptide, Antibody or Other Biomedical and Therapeutic Molecules and Reagents in Solid Organs - A methodology and apparatus for drug, gene, siRNA, shRNA shRNA peptide, protein, antibody or any other biomedical therapeutic reagents targeting in various of solid organs of large animals and humans ex vivo and in vivo is described. The delivery is assisted with the application of a low strength electric field network (LSEN). A low strength electric field network (LSEN) system is used for ex vivo or in vivo delivery of any therapeutic gene, siRNA, shRNA shRNA protein or drugs into a lung, pleura, breast, liver, spleen, pancreas, kidney, adrenal, prostate, testicle, ovary and tumors in chest, abdominal and pelvic cavity.05-13-2010
20090234271COMPOSITION COMPRISING siRNA-POLYCATION COMPLEX FOR IONTOPHORESIS - To provide a composition which is capable of efficiently delivering an siRNA intradermally and of effectively suppressing the expression of a target gene by an RNAi. Provided is a composition for iontophoresis including an siRNA-polycation complex which is charged negatively.09-17-2009
20090234270Therapy and device for treatment of nail infections - The present invention includes a method for treating fungal infections, particularly onychomycosis. The method includes: applying a composition includes a photosensitizer, an effective amount of antifungal agent, and a pharmaceutically acceptable delivery system to a locus and irradiating the locus with a light source at a wavelength absorbed by the photosensitizer so as to destroy microbes at the locus. The present invention also includes a light delivery device for use in photodynamic treatment of onychomycosis comprising (i) a housing adapted to cover a nail beneath which a locus is situated; (ii) a light source; (iii) an energy source in power communication to the light source; and a controller that controls amount of light to be applied to the locus by the light source.09-17-2009
20090234269System for tissue electroporation and method for use thereof - A device for electroporation of tissue is provided. The device includes a mist jet delivery nozzle arrangement that is connected to a pressurized gas source and also connected to a liquid source. The device also includes a charge generator in electrical communication with the liquid provided by the liquid source wherein the generator supplies charge to the liquid. The delivery nozzle arrangement is arranged and operative to accelerate and emit the pressurized gas and to accelerate and emit the liquid as a mist of accelerated charged droplets. The charged droplets alight, and then electrically discharge, on the tissue being treated. A system including the device and a method for using the device and system are also discussed09-17-2009
20090012446DEVICES, SYSTEMS AND METHODS FOR RELEASE OF CHEMICAL AGENTS - An electrode system includes at least one electrically conductive element to effect at least one of (a) delivery an electrical signal to living cells in the vicinity of the electrically conductive element or (b) measurement of an electrical signal from living cells in the vicinity of the electrically conductive element. The electrically conductive element includes a first conductive polymer which includes at least a first chemical agent to affect activity of the living cells. The first chemical agent is associated with the conductive polymer and is releasable from the first conductive polymer to interact with the living cells upon application of a first electrical potential to the electrically conductive element. As used herein, reference to a first electrical potential includes reference to a range or electrical potentials suitable to effect release of the chemical agent01-08-2009
20100087775METHODS AND SYSTEMS FOR TOXIN DELIVERY TO THE NASAL CAVITY - Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.04-08-2010
20130165845OXIDATITIVE PHOTOACTIVATED SKIN REJEUVENATION COMPOSITION COMPRISING HYALURONIC ACID, GLUCOSAMINE, OR ALLANTOIN - There is provided a skin rejuvenation composition which comprises at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmaceutically acceptable carrier.06-27-2013
20130165846METHODS TO REGULATE POLARIZATION AND ENHANCE FUNCTION OF EXCITABLE CELLS - Minimally invasive delivery with intercellular and/or intracellular localization of nano- and micro-particle solar cells within and among excitable biological cells to controllably regulate membrane polarization and enhance function of such cells. The cells include retinal and other excitable cells.06-27-2013
20120271220METHOD AND COMPOSITION FOR THE TREATMENT OR AMELIORATION OF FEMALE GYNECOLOGICAL INFLAMMATION - A method for treating inflammation of female genital area, the method including preparing a photo-active mineral composition of bischofite, aleurolite, magnesite and piezoquartz. The photo-active mineral composition is then inserted into a patient's rectum or vagina, where a piezo-electric current is generated and fed to the photo-active mineral composition, which generates infrared radiation in response to the fed piezo-electric current.10-25-2012
20090043244Electrotransport Drug Delivery Device Adaptable to Skin Resistance Change - Disclosed is a transdermal electrotransport drug delivery system having a constant current that can accommodate large resistance change in a body surface. A semiconductor circuit component such as a Zener diode or a PMOS FET is used to impose a voltage drop from the output of a voltage booster circuit to maintain a constant current for electrotransport. Methods for its use are also disclosed.02-12-2009
20110034858BATTERY-INTEGRATED IONTOPHORESIS PATCH - The present invention relates to an iontophoresis patch integrated with a battery, more specifically to an iontophoresis patch integrated with a battery which adopts the principle of iontophoresis as a means for infiltrating a substance of interest such as a medication or a cosmetic substance into skin. The iontophoresis patch of the invention comprises: a variable-shape substrate; a first electroconductive layer coming into contact with the substrate; a first electrode layer coming into contact with a part of the first electroconductive layer; a second electroconductive layer which comes into contact with the substrate and which is disposed on the same as the first electroconductive layer; a collector coming into contact with the second electroconductive layer; an electroconductive adhesive coming into contact with the second electroconductive layer and with the collector; a second electrode layer coming into contact with the collector and having a polarity opposite to that of the first electrode layer; an ion-conductive polymer electrolyte disposed between the first electrode layer and the second electrode layer; and an adhesive for sealing the ion-conductive polymer electrolyte.02-10-2011
20090024074Electrochemically degradable polymers - The present invention discloses polymeric materials that incorporate a modified quinone moiety, either to cross-link the polymer or as a monomeric unit of the polymer These polymeric materials can be efficiently degraded through electrochemical reduction of the quinone leading to rapid hydrolysis of the pendant chemical groups and degradation of the polymer. Quinone-containing compositions and methods of producing electrochemically degradable polymers are disclosed. The methods and compositions of the present invention can be used in a wide variety of applications, including, but not limited to, drug delivery, tissue regeneration, biomedical implants, and electronic systems.01-22-2009
20090048556IONTOPHORETIC DRUG DELIVERY SYSTEM - The iontophoretic drug delivery system includes electrodes controlled by a microprocessor controller to drive charged molecules contained in a drug reservoir through the skin into the issues of a patient. The iontophoretic drug delivery system further includes an antenna connected to the programmable microprocessor. The antenna allows for the programming of the microprocessor and for the exchange of patient, drug, and treatment related information between the microprocessor and an external device. The iontophoretic drug delivery system is also provided with buttons to allow a patient to manually activate the drug delivery system. The iontophoretic drug delivery system is housed within a thin polyester film membrane.02-19-2009
20090299264Electrode Assembly for Dry Type Iontophoresis - An iontophoresis device capable of stably holding a drug for a long time period and of transdermally administering the drug at a high transport number during use. The iontophoresis device includes a drug holding portion to store the ionic drug in a dry state and at least an aqueous medium holding portion to store an aqueous medium. The drug holding portion exhibiting ion conductivity in response to a needle inserted into the aqueous medium holding portion from outside the electrode assembly such that the drug holding portion is supplied with the aqueous medium during use and the ionic drug dissolves in the aqueous medium.12-03-2009
20090105632Electrotransport Of Lisuride - An electrotransport system for delivery of lisuride or a pharmaceutically acceptable salt thereof. The system has a donor electrode assembly, a counter electrode assembly, and a controller electrically connected to the donor electrode assembly and the counter electrode assembly. The donor electrode assembly has a donor reservoir that contains a lisuride salt. The controller is electrically connected to the donor and counter electrode assemblies and is operatable for controlling current for the electrotransport.04-23-2009
20120101427NOVEL PHOTOSENSITIZER FORMULATIONS FOR ORAL ADMINISTRATION - The present invention provides novel drug formulations for oral administration for diverse medical applications including anticancer, antimetastatic, antibacterial, antifungal, antiprotozoic, antiviral, antiprionic and PDT treatments for diagnostic and therapeutic purposes. In a preferred embodiment the oral drug formulation comprises a photosensitizer and suitable excipients and may be administered in multiple doses over an extended period of time with exposure to activating radiation occurring generally between individual doses or in a light-independent manner. In another preferred embodiment PDT methods for treating hyperplasia and neoplasia, for localizing hyperplasic and neoplasic tissues and pathogen bacteria by fluorescence, for treating infections caused by pathogen bacteria in complex body fluids and for fat reduction, skin disorders and vascular diseases are provided.04-26-2012
20120065575METHOD AND APPLIANCE FOR COSMETIC SKINCARE - The invention relates to the field of cosmetology. The invention relates to cosmetic or aesthetic skin treatment using an appliance, in particular for dermatological care, which combines applying pulsed electrical currents to the skin for treating the skin by electroporation in a first step, constant currents for electrophoretically treating the skin in a second step, with the simultaneous exposure of the skin under treatment to chromotherapeutic light emissions in which the colour changes from one step to the next. The colour red is preferred for electroporation; orange is preferred during the electrophoretic treatment. The appliance is programmed for automatic is programmed for automatic operation. The method advantageously comprises a third chromotheraphy step under blue light combined with the application of an electrophoretic current.03-15-2012
20100056982Photodynamic therapy for the treatment of acne - The present method involves the photodynamic treatment of acne vulgaris. The method involves the topical administration of a photosensitizer composition comprising hydrophobic green porphyrins such as lemuteporfin, polyethylene glycol and skin penetration enhancers such as oleyl alcohol and TRANSCUTOL™ to acne-affected skin and subsequent exposure of that skin to energy of a wavelength of activating the photosensitizer.03-04-2010
20100004583Hydrophobic Circuit Board Coating of Electrotransport Drug Delivery Devices - The present invention encompasses an improved electrotransport drug delivery device utilizing a hydrophobic modifier to prevent moisture condensation. Use of a hydrophobic modifier increases the hydrophobicity of coated parts of the device, reducing the amount of moisture uptake of the device during storage in a high humidity environment. In a further embodiment, a package of the improved electrotransport drug delivery device is provided. In addition, a method of reducing moisture condensation to an electrical device and a method of preserving an electrical device for an electrotransport drug delivery device are provided.01-07-2010
20090036821Iontophoretic Transdermal Delivery of Nicotine Salts - The present invention relates to iontophoretic transdermal delivery of nicotine salts useful for nicotine replacement therapy for an individual in need thereof. The present invention further relates to the iontophoretic transdermal delivery of nicotine maleate and nicotine citrate. Methods of reducing skin irritation generally caused by transdermal nicotine delivery by iontophoretic transdermal delivery of nicotine salts are also disclosed.02-05-2009
20120191032METHOD OF PROVIDING AGENTS TO THE COCHLEA - Provided is a method of transfecting cells of the cochlea with an agent by electroporation, and in certain embodiments using a cochlear implant to provide at least one electroporation electrode.07-26-2012
20110282266ILLUMINATOR FOR PHOTODYNAMIC THERAPY - An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. Adjustment of the ballast voltage controls the output power of the tubes. The tubes are supported by a sheet-metal or plastic housing and are covered by a polycarbonate shield which directs cooling airflow within the unit and prevents glass-patient contact in the vent of tube breakage. An aluminum reflector located behind the tubes increases both the output irradiance and the uniformity of the output distribution. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity. A light sensor monitors output from the U-shaped tubes to provide a signal for adjusting the output from the tubes.11-17-2011
20110282269WOUND CARE METHOD AND SYSTEM WITH ONE OR BOTH OF VACUUM-LIGHT THERAPY AND THERMALLY AUGMENTED OXYGENATION - A system for treatment of a wound area of a patient including a first treatment pad comprising a plurality of Light Emitting Diodes (LEDs) for cleaning and exposing a wound area to ultraviolet light, a second treatment pad comprising removal ports for exposing the wound area to a negative pressure, and a control unit interoperably connected to the first and second treatment pads for providing a negative pressure and the ultraviolet light to the wound area.11-17-2011
20110282268Methods and Systems for Delivery of Fluids and Aerosols to Tissue Surfaces, Cavities and Obstructed Passages such as Intranasal Ostia - Methods and systems for delivering fluids, aerosols, and/or acoustic energy to target sites on tissue surfaces and within body cavities or lumens, obstructions or undesired materials associated with body cavities and tissue surfaces and, particularly, target sites on tissue surfaces or at obstructions within natural orifices, such as ear, nose and throat passages and, particularly, nasal passages and cavities, are provided. In one aspect, methods and systems for delivering fluids and/or aerosols to target sites such as nasal passages at generally high frequency (e.g., sonic and ultrasound) pulsation rates and at multiple, alternating pulsation rates are provided.11-17-2011
20110282267FIBROBLAST GROWTH FACTOR-9 PROMOTES HAIR FOLLICLE REGENERATION AFTER WOUNDING - The present invention provides methods for treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, treating androgenetic alopecia (AGA), generating new hair follicles (HF), and increasing the size of existing HF. The methods comprise epidermal disruption or administration of wnt, and administration of a fibroblast growth factor-9 polypeptide or another compound that upregulates sonic hedgehog gene signaling.11-17-2011
20110282265METHOD AND APPARATUS FOR THE DELIVERY OF PLYNUCLEOTIDE VACCINES TO MAMMALIA SKIN - An object of the invention is to provide a method and apparatus for the delivery of polynucleotide vaccines into mammalian skin cells to increase T cell response and reduce pain and discomfort due to long electric waveform application and due to muscle contractions. The method includes administering a polynucleotide vaccine into the skin at an administration site, (b) applying a needle electrode to the skin in the vicinity to the administration site, and (c) applying a sequence of at least three single, operator-controlled, independently programmed, narrow interval electrical waveforms, which have pulse intervals that are less than 100 milliseconds, to deliver the 15 polynucleotide vaccine into the skin cells by electroporation.11-17-2011
20110125076PHOTOKINETIC OCULAR DRUG DELIVERY METHODS AND APPARATUS - The present invention relates generally to transscleral, transcorneal, and transocular delivery of biologically active substances through the tissues, blood vessels and cellular membranes of the eyes of patients without causing damage to the cellular surface, tissue or membrane. The invention provides compositions and methods for enhanced transscleral, transcorneal and transocular delivery of biologically active substances using pulsed incoherent light, and particularly the transcleral, transcorneal or transocular delivery of high molecular weight biologically active substances to a patient using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes of the eye of a subject using those compositions and methods.05-26-2011
20100016782Method of Regulating Hair Growth - Method for regulating hair growth, comprising the steps of applying a composition to keratinous tissue comprising the hair in need of regulation, said composition comprising at least one PARP-1 inhibiting compound; and delivering energy to the keratinous tissue by means of an energy delivery device.01-21-2010
20110301530MONITORING OF CHRONOBIOLOGICAL RHYTHMS FOR DISEASE AND DRUG MANAGEMENT USING ONE OR MORE IMPLANTABLE DEVICE - The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.12-08-2011
20110301525BIOMATERIALS FOR TISSUE REPLACEMENT - This invention relates to biomaterial compositions, methods and kits for producing hydrogels with tunable physico-chemical properties. Specifically, the invention relates to producing cellulosic hydrogels having optimized physico-chemical properties enabling support of cell growth or as replacement or filler for tissue repair, reconstruction or augmentation.12-08-2011
20080300529Skin Care Method and Kit Using Peltier Thermoelectric Device - One embodiment provides a method of treating the skin or body part, comprising contacting the skin or body part with a composition; and contacting the composition and heating and/or cooling the skin or body part with a thermoelectric Peltier device. Another embodiment provides a skin care kit, which comprises a composition suitable for application to the skin; and a thermoelectric Peltier device configured to contact the composition and to heat and/or cool the skin. Other embodiments are also disclosed.12-04-2008
20110301527Moist Heat Drug Delivery Apparatus and Method - A novel moist steam heating cabinet unit is used as a medical device for humidification, hydration and dispensing of medicinal Hot Packs. The technology provides multifunctional options for both medicinal and non medicinal hot pack treatment as well as for other applications and uses, for example—including creation, manufacturing and curing of pharmaceutical compounds that require a controlled steam process and method. A moist heating device is a unit designed and constructed to deliver a timed, heated fluidic steam coming from a moisture generating heating source. This moist heating by employing steam heat activates the therapeutic potential of a portable topical compress or hot pack wrap applicator, of various shapes and sizes, for transdermal use and neat applications of a “wet medicinal dressing.” The moisture provides the activating liquid and fluidic environment for the flowing through, titrating, and permeating delivery of drugs or medicaments held within a medicinal pack.12-08-2011
20110301526SYSTEM AND METHOD FOR OCULAR IONTOPHORESIS WITH BUFFERING - Compositions, devices, methods of manufacture, and methods of delivery of a therapeutic substance across a surface of an eyeball via iontophoresis including a therapeutic media reservoir and a buffer system within an iontophoretic chamber. When energized, an electrode provides an electromotive force that transfers a dosage of the therapeutic substance from the iontophoretic chamber across the surface of the eyeball. The buffering system includes a buffer media and at least one buffer element, or agent that regulates pH during iontophoretic transfer of the therapeutic substance. The buffer media includes at least one of a foam, a gel (solid or liquid), a membrane, and a plurality of multiparticulates. The buffer media can be included within the iontophoretic chamber, together with the therapeutic media reservoir, in various arrangements including one or more layers and one or more concentric cylinders.12-08-2011
20110301524CONTROL PROGRAM FOR CONTROLLING ELECTROMAGNETIC RADIATION FOR CROSS-LINKING EYE TISSUE - A control program for controlling a source of electromagnetic radiation, with which a cross-linking in eye tissue of a patient is implemented by means of a photosensitiser introduced into the tissue in order to bring about a change in the eye tissue with reference to its form and/or one of its mechanical properties, the control program having been produced with the following steps: 12-08-2011
20100004584Apparatus and Method for In Vivo Intracellular Transfection of Gene, SIRNA, SHRNA Vectors, and Other Biomedical Diagnostic and Therapeutic Drugs and Molecules for the Treatment of Arthritis and Other Orthopedic Diseases in Large Animals and Humans - An apparatus for in vivo intracellular transfection of gene, siRNA, shRNA vectors, and other biomedical diagnostic and therapeutic drugs and molecules for the treatment of arthritis and other orthopedic diseases in large animals and humans includes: a source of low voltage, short duration pulses in long duration bursts (LSEN); an electrode mesh system coupled to the source for generating distributed electric field network into a joint, including bones, cartilages, and related tissues; and means for transfecting the gene, siRNA, shRNA vectors, and other biomedical diagnostic and therapeutic drugs and molecules into a joint. The electrode mesh system includes alternatively arranged negative and positive electrodes in a first array which is capable of being inserted into a joint cavity, and either an alternatively arranged negative and positive or an all negative second electrode array which is positioned outside of the joint and in directly contact with overlying skin.01-07-2010
20090281476Method, Tool, and Kit for Making a Subcutaneous Pocket - The present disclosure generally relates to a tool, a kit including said tool, and a method of use of the tool or the kit for making a subcutaneous pocket in a layer of fat for the introduction of a subcutaneous medical device, and more specifically, a tool, kit, and method of use thereof using a calibrated inflatable volume with a guide to open a subcutaneous pocket at the appropriate location in a body by inflating the volume to the appropriate size. The tool is calibrated to rest against a layer of muscle using a guide wire and inflate in a specific shape to a specific volume to gently displace fatty tissue that may obstruct the implantation of a subcutaneous device between the skin and the ultimate resting place. The tools allows for creating localized lateral retraction in an area of interest without placing strain on the skin or the muscle. A kit using the tool further includes surgical equipment needed for the surgery.11-12-2009
20110288466SYSTEMS AND METHODS FOR ACTIVATING CROSS-LINKING IN AN EYE - Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.11-24-2011
20110288467METHOD AND APPARATUS FOR DELIVERY OF THERAPEUTIC AGENTS - Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a patient. The invention includes controlled administration of the therapeutic agent through an orifice to the patient, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and an electrical signal generator operatively connected to the electrodes.11-24-2011
20120191033CORRECTIVE METHOD FOR FINGERNAILS OR TOENAILS - The disclosure relates to a method for correcting a fingernail or toenail, comprising the application of at least one layer and the performance of at least one treatment step, wherein the at least one layer contracts or expands, as well as a fingernail or toenail that can be produced with the method.07-26-2012
20110295188IONTOPHORETIC ELECTRODE - An electrode for an iontophoretic drug delivery system includes a retainer having a malleable characteristic. The retainer and a conductor are connected to a platform. The conductor and a dose controller are electrically coupled to the iontophoretic drug delivery system. A drug delivery matrix is operably connected to the platform and proximate the conductor wherein the conductor, the drug delivery matrix, and the dose controller cooperate to deliver a drug to a user when the electrode is affixed to the user and operably connected to the iontophoretic drug delivery system.12-01-2011
20110295189IONTOPHORETIC PREPARATION FOR TREATMENT OF BREAST CANCER AND/OR MASTITIS - The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing them efficiently to arrive into the mammary gland. The present invention provides an iontophoretic preparation for treating breast cancer and/or mastitis which contains a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent as an active ingredient and has a donor to be applied on a nipple part for topical administration of the active ingredient from the nipple part to the mammary gland by application of electric potential.12-01-2011
20110295190Wound Dressing and Methods of Making and Using the Same - Anti-microbial wound dressings, methods of making anti-microbial wound dressings and methods of treating wounds with an anti-microbial wound dressing are provided. The anti-microbial wound dressings can include a water-soluble film-forming polymeric carrier material and a water-soluble glass-encapsulated anti-microbial agent, which is embedded within the carrier and/or coated on a surface thereof. Additional active agents useful in wound care can also be embedded in and/or coated on a surface of the carrier and/or water-soluble glass.12-01-2011
20110295187Fat Reduction Using External Laser Radiation and Niacin - The present invention is a non-invasive method for reducing fat or cellulite in a patient by administering a therapeutically effective amount of niacin and applying laser energy to targeted external regions of a patient's body. The present method helps create smooth contours.12-01-2011
20110295186IRRADIATION DEVICE - An irradiation device for insertion into an orifice of the body for providing photodynamic therapy or diagnosis comprises: a housing 12-01-2011
20110295185Intestinal Brake Inducing Intraluminal Therapeutic Substance Eluting Devices and Methods - Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems and ingestible pills. In one embodiment, a method of producing satiety comprising the steps of accessing a gastrointestinal tract of a patient and implanting an intraintestinal therapeutic substance eluting implant. The implant is capable of eluting a satiety inducing substance selected from at least one of a nutrient, a specific satiety inducing bio-active substance, pancreatic polypeptides, free fatty acids, cholecystokinin, amino acids, glutamine, lipids, linoleic acid, or a combination thereof, from the implant into the gastrointestinal tract.12-01-2011
20110295184Preparation and Iontophoretic Device for the Transdermal Application of Active Ingredients - The present invention relates to an iontophorectic device and a composition comprising active ingredients for the transdermal release of active ingredients, particularly of human insulin. Insulin, a blood sugar-lowering hormone inhibiting glycogen breakdown of the pancreas, can be made available as the most important pharmaceutical for the therapy of diabetes mellitus via the transdermal resorption route.12-01-2011
20120065572Corneal crosslinking methodology using custom etched contact lenses - An improved methodology for the treatment of corneal abnormalities involving the application of a crosslinking solution, such as riboflavin, to the surface of the cornea followed by exposure to UV light such that the rigidity of the cornea is increased and stabilized, the method improved by providing a transparent contact lens that is selectively etched to create areas on the lens that either preclude or reduce penetration of UV light, thereby eliminating or reducing crosslinking for areas of the cornea that do not require stabilization while allowing penetration of UV light to areas of the cornea that do require stabilization.03-15-2012
20080208106METHODS OF PREDICTING DOSE OF DRUG AND PROGRAM FOR PREDICTING DOSE OF DRUG - A migration M of a drug ion in a membrane type iontophoresis device for administering the drug ion through a first ion exchange membrane is predicted on the basis of a migration C of the drug ion from the first ion exchange membrane to the outside of the device in the case where a voltage is applied to an electrode by using the device under such a condition that the first ion exchange membrane is not brought into contact with the skin of a living organism and a migration R of the drug ion to a liposome caused by mixing a liposome solution having a predetermined concentration and a drug solution containing a predetermined concentration of the drug ion.08-28-2008
20090177139System, devices, and methods including actively-controllable electromagnetic energy-emitting delivery systems and energy-activateable disinfecting agents - Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.07-09-2009
20120191031WOUND CARE METHOD AND SYSTEM WITH ONE OR BOTH OF VACUUM-LIGHT THERAPY AND THERMALLY AUGMENTED OXYGENATION - A system for treatment of a wound area of a patient including a first treatment pad comprising a plurality of Light Emitting Diodes (LEDs) for cleaning and exposing a wound area to ultraviolet light, a second treatment pad comprising removal ports for exposing the wound area to a negative pressure, and a control unit interoperably connected to the first and second treatment pads for providing a negative pressure and the ultraviolet light to the wound area.07-26-2012
20100036310INTEGRATED PATIENT MANAGEMENT AND CONTROL SYSTEM FOR MEDICATION DELIVERY - An integrated patient monitoring and control system is provided which includes a sample set, the sample set being adapted for coupling to the patient to obtain a specimen from the patient, a sensor, the sensor being adapted to receive the specimen from the sample set and to analyze the sample, a medication control unit, the medication control unit receiving information from the sensor, and utilizing that information to determine medication dosing information for the patient, and a medication administration system, the medication administration system receiving the dosing information from the medication control unit, and adapted to cause administration of the medication to the patient. If the sample set is adapted for blood draw, the system advantageously is performed in conjunction with a pneumatic pressure cuff, inflated so as to aid in blood draw.02-11-2010
20100004582Wide-Area Parasystemic Treatment of Skin Related Conditions - Use of an immunomodulatory, immunostimulatory, or immunosuppressive drug in the manufacture of a medicament for treatment of a skin related disease or disorder, wherein the drug is formulated for topical administration to porated skin having a plurality of pores with predetermined geometry such that the concentration of the drug in combination with the predetermined geometry of the pores are effective in treatment of the skin related disease or disorder. The method of facilitating treatment of a skin related disease or disorder, comprising providing information that a drug is effective in treatment of the skin related disease or disorder; providing information to apply the drug to an area of porated skin comprising a plurality of pores; wherein the information specifies that the area is equal or greater than 1 cm01-07-2010
20100076368Electrotransport Delivery Device Having Improved Safety and Reduced Abuse Potential - An electrotransport device for delivering one or more therapeutic agents through the skin includes electrodes for contacting the skin, at least one electrode containing the agent, a power source for generating electrical current (I03-25-2010
20100114007DERMATOLOGICAL TREATMENT APPARATUS - An apparatus for dermatological treatments has a base equipment 05-06-2010
20100114008Controlled release transdermal drug delivery - Provided herein is a device for controlling the release of a substance at a site of interest in a biological membrane comprising a means of monitoring a physiological state at the site of interest; and a means of releasing a variable amount of the substance to the site of interest where the amount varies in response to the status of the monitored physiological state. Also provided are methods of using the device.05-06-2010
20110264027B RING REDUCED-D RING OXIDIZED TETRAPYROLLIC PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY AND TUMOR IMAGING - Tetrapyrollic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl10-27-2011
20110270151IMAGE-GUIDED ENERGY DEPOSITION FOR TARGETED DRUG DELIVERY - Disclosed are compositions and methods for targeted drug delivery using image-guided energy deposition to help localize active compounds to particular sites within the body of an animal. Also provided are compounds and formulations thereof for use in the targeted administration of therapeutically, prophylactically, and/or diagnostically effective amounts of such agents to a population of cells or tissues of a mammal in need thereof.11-03-2011
20100094195SYSTEMS AND METHODS FOR DELIVERING A MEDICAMENT - A medicament containment device (04-15-2010
20110125079Echogenic Polymer Microcapsules and Nanocapsules and Methods for Production and Use Thereof - Methods for producing echogenic polymer microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive compounds as well as targeted imaging and delivery to selected tissues and cells are provided. Compositions containing these echogenic polymer microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive agents are also provided.05-26-2011
20080269664System and Method For Controlling Traversal of an Igested Capsule - A treatment system (10-30-2008
20090149800IONTOPHORETIC DRUG DELIVERY DEVICE AND SOFTWARE APPLICATION - The iontophoretic drug delivery system includes electrodes controlled by a microprocessor controller to drive charged molecules contained in a drug reservoir through the skin into the issues of a patient. The iontophoretic drug delivery system further includes an antenna connected to the programmable microprocessor. The antenna allows for the programming of the microprocessor and for the exchange of patient, drug, and treatment related information between the microprocessor and an external device. The iontophoretic drug delivery system is also provided with buttons to allow a patient to manually activate the drug delivery system. The iontophoretic drug delivery system is housed within a thin polyester film membrane.06-11-2009
20090149798Implant system for chemical modulation of neural activity - Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Implantable systems for delivery of chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.06-11-2009
20090149797System for reversible chemical modulation of neural activity - Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.06-11-2009
20130218066FLUID DISPENSER - A fluid dispenser comprising: 08-22-2013
20120310140DIRECTED DELIVERY OF AGENTS TO NEURAL ANATOMY - The present invention is directed generally to systems, devices and methods for direct delivery of agents, e.g., pharmaceutical agents, to target spinal and neuronal anatomies, e.g., the dorsal root ganglia (DRG), for the treatment of various disorders, particularly pain and pain related disorders, such as chronic itch, sensory disorders, multiple sclerosis, post-herpetic neuralgia and the like. The system, devices and methods of the invention encompass the agents to be delivered to the target anatomy alone or in combination with electrical stimulation. The delivery device and systems and methods as disclosed herein place the distal end of the delivery element, which comprises at least one agent delivery structure, and optionally at least one electrode, in close proximity, or in contact with or next to the target spinal anatomy, e.g., DRG. A variety of agents can be delivered using the device, including sodium channel blockers, biologics, neuroinflammatory modulators, toxins etc., to selectively neuromodulate the neurons. Agent delivery and/or electrical stimulation can be automated and/or can be controlled automatically or by a pre-determined program, or by a patient control pump (PCA).12-06-2012
20120109042Methods of Treating Diseased Tissue - Two or three external therapeutic options such as clobetasol propionate spray, calcitriol ointment, and excimer laser phototherapy are used to treat generalized psoriasis with systemic safety and better efficacy than any systemic or biologic agent. Combinations of these agents, for example used in parallel and/or series for specific durations, can achieve a significant result: a PASI 75 response after only four weeks and/or a PASI 95-100 response after only six weeks.05-03-2012
20090259166Systems and Methods for Transdermal Photo-Polymerization - Systems and methods of polymerizing compositions with a light source may be provided. A device may include a handheld light source, which may include an LED, which may provide light at limited wavelengths to polymerize a composition. The device may be used to photo-polymerize dermal fillers transdermally via ex vivo applications. Dermal fillers may be compositions including PEODA 3400 and eosin Y, which may be polymerizable when exposed to light.10-15-2009
20090088679Electronically-Degradable Layer-by-Layer Thin Films - A decomposable thin film comprising a plurality of alternating layers of net positive and negative charge. At least a portion of the positive layers, the negative layers, or both, comprise a polyelectrolyte.04-02-2009
20090149799Method for chemical modulation of neural activity - Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.06-11-2009
20080208107TRANSDERMAL PORATOR AND PATCH SYSTEM AND METHOD FOR USING SAME - A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.08-28-2008
20080208105LASER ENERGY DEVICE FOR SOFT TISSUE REMOVAL - This invention relates to a device and method for improving the surgical procedure of soft tissue removal by aspiration and more particularly to a device and method utilizing laser energy directed substantially across the inlet port to more readily and safely facilitate the separating of soft tissue from a patient in vivo. This invention has immediate and direct application to the surgical procedure of liposuction or body contouring as well as application in the surgical procedures of other soft tissue removal such as brain tissue, eye tissue, and other soft tissue inaccessible to other soft tissue aspiration techniques.08-28-2008
20100100030Microbe Reductions with Photosensitizers - Methods, devices and composition are disclosed for treating oral, skin and nail diseases, including inflammatory periodontal disease, onychomycosis and dermatophytosis. In a preferred embodiment a method for treating oral, skin and nail infections comprises administering a photosensitizing compound in long term effect or timed release formulations, including local highly concentrated formulations, and activating the photosensitizer with radiation to selectively destroy bacteria, fungi and other microbial bodies. In another preferred embodiment, photosensitizers are housed within nanoparticles, and can be gradually released through biodegradation or periodically released by such processes as brushing, irradiation and chemically induced release. The diffusion speed of the photosensitizers can be accelerated by brushing. In another embodiment, the photosensitizer molecule is also modified to more effectively target the molecule to the unwanted oral bacterial and fungal species. In another embodiment devices for treating oral, skin and nail infections includes a laser radiation source and delivery apparatuses such as brush or teethed comb for nail and scalp infections respectively.04-22-2010
20100100029GLAND OR DUCT DIAGNOSTIC AND TREATMENT METHODS AND RELATED APPARATUS - A method is provided for treating a gland or duct of a patient. In a particular embodiment, an obstruction in a gland or duct and the orifice thereof can be alleviated; in another, a substance can be injected thereinto; in yet another, the gland can be aspirated. The method includes the step of inserting an elongated probe into a gland or duct via an orifice thereinto. In some embodiments the probe can have a longitudinal lumen therethrough, with at least one distal hole through the probe wall in fluid communication with the lumen. The lumen can be used in concert with a source of suction for removing debris from the gland or duct, and/or with a source of a fluid and pumping means, for injecting a substance into the gland or duct.04-22-2010
20090299266METHOD AND APPARATUS FOR SKIN ABSORPTION ENHANCEMENT AND TRANSDERMAL DRUG DELIVERY - A disposable head for attachment to a probe provides a substance to a patient's skin during a skin treatment procedure. The disposable head includes an attachment device for attaching the disposable head to a probe that provides at least electronic bursts of pulses to the patient's skin during the skin treatment procedure. The disposable head also includes at least one substance holding region for holding the substance prior to the skin treatment procedure. The disposable head includes a top part that includes at least one duct for providing the substance to the patient's skin. The disposable head also includes at least one piston that pushes the substance from the at least one substance holding region to the patient's skin via the at least one duct.12-03-2009
20090299263Near-Infrared electromagnetic modification of cellular steady-state membrane potentials - Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (ΔΨ-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ΔΨ of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ΔΨ, the affiliated weakening of the proton motive force Δp, and the associated lowered phosphorylation potential ΔGp. Within the area of irradiation exposure, the decrease in membrane potentials ΔΨ will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.12-03-2009
20090287137MUCOSAL ABLATION - An interventional device uses light to diagnose and treat tissue regions near the surface. A high intensity ultraviolet light is used. The interventional device includes a housing adapted for placement inside a body and a flash lamp placed inside the housing. The flash lamp is capable of generating high intensity ultraviolet light.11-19-2009
20090287138LASER ASSISTED THERAPEUTIC AGENT DELIVERY INTO A TARGETED TISSUE - The present invention involves selectively breaking down or altering a blocking tissue by irradiating the blocking tissue with a laser irradiation. Breaking down the blocking tissue allows the delivery of therapeutic agents through the blocking tissue to a target tissue. An area of the blocking tissue is selected for treatment. The selected area is irradiated with a laser to induce an alteration or breakdown of the blocking tissue. Areas not irradiated are not affected. Once the selected area of the blocking tissue is treated, a therapeutic agent can be delivered to the selected area and passed through the altered or broken down blocking tissue to the target tissue. The blocking tissue will then undergo a healing response after a period of time. The present invention may be used to treat the retina or subretinal space of a patient's eye through the blocking tissue of the Retinal Pigment Epithelium (RPE).11-19-2009
20090299262Microporator for Creating a Permeation Surface - There is disclosed a method for creating an initial permeation surface (A) in a biological membrane (12-03-2009
20090299267IONTOPHORETIC DRUG DELIVERY SYSTEM WITH PROCEDURE WINDOW - The current invention is directed to an iontophoretic drug delivery system which drives charged drug molecules into a tissue, which comprises a body configured to be disposed on the tissue; a procedure window extending through said body, said window being open to provide access to the tissue for performance of a medical procedure on the tissue; a drug reservoir for holding the charged drug molecules; an electrode for driving the charged drug molecules into the tissue; and a controller configured to control the electrode.12-03-2009
20110208110Moringa oil mediated activation of the alyternative cellular energy pathway in the therapy of diseases - A convenient method for activating the alternative cellular energy (ACE) pathway is described that uses ultraviolet (UV) light illumination of oil extracted from the leaves of the 08-25-2011
20130218067CONTENT REPRODUCTION APPARATUS, CONTENT REPRODUCTION METHOD, AND STORAGE MEDIUM - A content reproduction apparatus includes a storage unit storing a plurality of content files and performs treatments by playing the content files stored in the storage unit. The content reproduction apparatus also includes a treatment setting unit configured to set a treatment based on a treatment condition input by a user; a content file obtaining unit configured to obtain, from the storage unit, a content file corresponding to the treatment set by the treatment setting unit; and an edit-and-output unit configured to play the content file obtained by the content file obtaining unit or the content file edited according to an instruction of the user.08-22-2013
20090036822Electrotransport Agent Delivery Method and Apparatus - An electrotransport device for delivering or sampling an agent through a body surface by electrotransport, the device having a housing including an upper, exterior housing portion and a lower housing portion, the housing enclosing electronic components, and at least one hydratable or hydrated reservoir containing water or an at least partially aqueous solution of the agent. At least a portion of the housing is composed of an ethylene-octene copolymer.02-05-2009
20100137779SYSTEMS, DEVICES, AND METHODS FOR POWERING AND/OR CONTROLLING DEVICES, FOR INSTANCE TRANSDERMAL DELIVERY DEVICES - Systems, devices, and methods for powering and/or controlling active or electrically powered transdermal delivery devices employ a magnetic field blocker such as a ferrous disk between a magnetic coupler element and a battery to counter adverse affects on the battery by the magnetic coupler element.06-03-2010
20080255497Getter Device for Active Systems for the Transdermal Release of Drugs - A getter system (10-16-2008
20080255498Sensitizer Solutions, Systems, and Methods of Use - A kit cleaning system and method is disclosed. One embodiment of the present invention has a photosensitizer solution supplied by a pressurized nozzle to the target site. Specific application of the solution is to an oral or skin surface target site. The photosensitizer solution is illuminated with sensitizing light creating reactive chemical species. Pressure and a solvent having an elevated concentration of oxygen or oxygen species improve the efficiency of the killing of pathogens. Methods of using the system within an oral cavity are also disclosed.10-16-2008
20110270153CELL STIMULATION USING QUANTUM DOTS - The present invention provides methods for stimulating cells using quantum dots. In addition, the present invention provides methods for treating a variety of clinical conditions using stimulation of quantum dots to induce cell stimulation and/or function.11-03-2011
20080287856Process and apparatus for treating biological organisms - An apparatus for treating a biological organism comprising a device for emitting and delivering energy to the biological organism, a programmable controller for varying the type and amount of energy emitted, and apparatus for sensing a condition of the biological organism.11-20-2008
20080287855SYSTEM AND METHOD FOR MANAGING DETRIMENTAL CARDIAC REMODELING - A system and method for managing and inhibiting cardiac remodeling in MI patients. Bi-ventricular stimulation is constantly provided with and without sensing to encourage normal pumping of the heart on a consistent basis. Pulses are administered using an anodal pulse followed by a cathodal pulse to stimulate cardiac muscle contraction. Stem cells are administered to MI areas to encourage regeneration of cardiac tissue in the damaged area. Stimulation may be provided to both healthy and compromised cardiac tissue.11-20-2008
20080312579METHOD AND SYSTEM FOR MITIGATING CURRENT CONCENTRATION IN ELECTROKINETIC DRUG DELIVERY - An electrokinetic apparatus to apply medicament to a treatment site of a mammalian user, the apparatus including: a segmented active electrode; a medicament matrix having one side abutting the segmented active electrode and another side adapted to contact a surface of skin over the treatment site, wherein the matrix includes at least one current direction barrier suppressing transverse current flow through the matrix.12-18-2008
20100217176METERED GEL DISPENSER - The invention relates to a dermal flowable-composition dispenser that includes a body for retaining a supply of the composition, an application portion having an application surface, and a conduit connecting the supply chamber with the application surface for facilitating the reproducible delivery of a predetermined dose of the composition to the application surface. The application surface includes a concave application surface and a front side having an upper rim enclosing the application surface and forming a depression that has a volume that is greater than or equal to the volume of the predetermine dose. Also, the application surface is configured and dimensioned such it can receive the patient's skin to allow for removal of the predetermined dose of the composition, and wherein the concave application surface is shaped such that the entire application surface contacts the patient's skin when the application surface is pressed thereagainst.08-26-2010
20120296263TOPICAL AMINOLEVULINIC ACID-PHOTODYNAMIC THERAPY FOR THE TREATMENT OF ACNE VULGARIS - Light treatments of sebaceous gland disorders with 5-aminolevulinic acid and photodynamic therapy are disclosed. A preferred treatment includes topical application of 5-aminolevulinic acid to the skin followed by light exposures with repeated treatment at various intervals. At low doses of ALA and photodynamic therapy (PDT) in single or multiple treatments, improvement in the sebaceous gland disorder, e.g., acne, provides the discovery that diminishment in sebum secretion and the eradication of bacteria occurs. At high doses of ALA and a single high energy PDT treatment, permanent changes to the sebaceous gland and sebum secretion have been discovered.11-22-2012
20120296259SOLID DRUG DELIVERY APPARATUS AND FORMULATIONS AND METHODS OF USE - Embodiments provide apparatus and methods for delivering solid form medications such as pellets to various locations in the body. One embodiment provides an apparatus for in vivo delivery of medication pellets comprising a first chamber including an opening; a second chamber substantially surrounding the first chamber, a carriage disposed in the first chamber, a mechanism for transferring the medication pellets from the first chamber to the second chamber and a pusher plate. The carriage can hold and dispense a plurality of medication pellets. Each pellet contains a selected dose of drug to treat a medical condition. A catheter is positioned in the second chamber. The catheter has a lumen sized for the pellet, a proximal end inside the chamber and a distal end extending through chamber opening to deliver the pellet to a delivery site. The pusher plate engages and advances the pellet though the catheter to the delivery site.11-22-2012
20120296262ENERGY FACILITATED COMPOSITION DELIVERY - A device for delivering a composition to a hollow body region is disclosed. In one aspect, the device comprises a first longitudinal member and a second longitudinal member. Both of the longitudinal members may comprise conductive electrodes. The longitudinal members are further configured to be connected to an energy source such that the conductive electrodes are configured to generate an energy field. At least one of the longitudinal members further comprises a delivery element configured to deliver at least one composition to the body region, such that the composition is delivered in a direction that is influenced by the generated energy field. In one aspect, the body region is a vessel comprising an occlusion.11-22-2012
20120296260DEVICE AND METHOD FOR PHOTODYNAMIC THERAPY - The invention relates to an apparatus for photodynamic therapy and/or for destroying or reducing microorganisms, comprising an irradiation unit having at least one light source, by means of which a photosensitizer applied to a wound area to be treated is activated by way of irradiation, further comprising a camera for recording images of the wound, which is disposed in the irradiation unit, and a positioning unit, by means of which the irradiation unit can be oriented with respect to the wound area. The invention further relates to a method for operating such an apparatus. On a display for the images is a grid with visual indicia distinguishing fields to be irradiated by means of the light sources.11-22-2012
20090318846METHODS AND APPARATUS FOR SURFACE ABLATION - The various embodiments of the present invention relate generally to methods and apparatus for surface ablation. More particularly, various embodiments of the present invention are related to methods and apparatus for ablation of barrier surfaces, such as skin, to increase the permeability of the barrier surface. Embodiments of the present invention comprise rapid thermo-mechanical ablation of the skin by a microfluidic jet generated by an arc discharge to produce micron-scale holes localized to the stratum corneum, which increases skin permeability.12-24-2009
20120046598Contactless Electropermeabilization Electrode and Method - Devices and methods for delivering an electropermeabilizing pulse of electric energy to a tissue surface to enable delivery into cells in the tissue therapeutic substances. The device incorporates a source capable of generating a sufficient voltage potential to deliver a spark across a gap and delivers same to the tissue surface.02-23-2012
20090264810Transdermal Integrated Actuator Device, Methods of Making and Using Same - The invention provides for an integrated device for forming a cavity in a surface of a tissue of an animal comprising: a) a controller board connected to an energy source for actuating at least one porator; b) a fluid reservoir in fluid communication with the tissue; and c) a tissue interface layer, the tissue interface layer containing the at least one porator, the porator in contact with the tissue for forming the cavity. The invention also provides for methods of making and methods of using the same.10-22-2009
20120296261DELIVERY DEVICE AND DELIVERY METHODS - Various delivery devices and methods are disclosed, including a delivery device (11-22-2012
20100298760METHODS, KITS, AND COMPOSITIONS FOR ADMINISTERING PHARMACEUTICAL COMPOUNDS - The invention features methods, kits, and compositions for administering pharmaceutical compounds using microdermabrasion particles.11-25-2010
20100298758METHOD FOR NON-THERAPEUTIC OR THERAPEUTIC PHOTODYNAMIC SKIN TREATMENT - In a method for non-therapeutic or therapeutic photodynamic treatment of a skin target area, a photosensitizer fluid incorporating a photosensitizing agent or a precursor for a photosensitizing agent is delivered to the target area, the photosensitizing agent having at least one absorption wavelength in a wavelength range higher than 400 nm. The target area is then exposed to light energy in a range of wavelengths comprising at least one absorption wavelength of the photosensitizing agent, the light energy being supplied to the target area in the form of at least one light pulse producing in the target area an accumulated energy density sufficient for photodynamic activation of the photosensitizing agent. The photosensitizing agent or precursor is incorporated in the photosensitizer fluid with a concentration in the range from 0.1 to 2.0% preferably from 0.1 to 0.9%, and the photosensitizer fluid is delivered to the target area in the form of a number of repeated spray doses during an overall delivery time ranging from 0.25 to 8 hours. The method can be applied to cosmetic treatments for skin rejuvenation, reduction of wrinkles, treatment of telangiectasia or removal of hair as wells a medical treatment of dermatologic diseases such as acne vulgaris, acne scars, rosacea, psorieasis, actinic keratoses, basal cell carcinoma, Bowen's disease or eczema.11-25-2010
20100137780APPARATUS AND METHOD FOR DELIVERING A THERAPEUTIC AGENT TO OCULAR TISSUE - An apparatus for delivering at least one therapeutic agent to an ocular tissue of a subject includes at least one electrode, a medicament layer including the at least one therapeutic agent, an electrical signal source, and logic configured to control the electrical signal source. The at least one electrode has oppositely disposed, dome-shaped first and second major surfaces. The first major surface is curved such that the first major surface substantially conforms to the contour of the ocular tissue when placed in contact with the ocular tissue. The medicament layer is disposed on at least a portion of the second major surface. The electrical signal source provides a signal having certain characteristics and is electrically connected to the at least one electrode. The certain characteristics comprise at least one orienting frequency and at least one motivating frequency sufficient to motivate the at least one therapeutic agent into the ocular tissue.06-03-2010
20100145256METHODS AND COMPOSITIONS FOR TATTOO REMOVAL - Methods and formulations for removing a tattoo by using a cell disrupter in combination with a vasodilator, and optionally one or more of an osmotic modifying agent, a chelation agent, and an occlusive modifying agent. Embodiments optionally further include using one or more of an antibiotic, anesthetic, penetration enhancer, excipient, carrier and vehicle.06-10-2010
20110270152THERAPEUTIC AGENT DELIVERY DEVICE FOR DELIVERY OF A NEUROTOXIN - A therapeutic agent delivery device and method for eluting a therapeutic agent to a target location are disclosed. The therapeutic agent delivery device may comprise a first conductive element, a second conductive element, and an electrochemical layer including a neurotoxin located between the first conductive element and the second conductive element. The first conductive element and the second conductive element are adapted to be connected to a voltage source. When the first conductive element and the second conductive element are connected to the voltage source, an electrochemical reaction occurs causing the neurotoxin to release from the electroactive layer and elute to a target location.11-03-2011
20110208111Electrokinetic Delivery System for Self-Administration of Medicaments and Methods Therefor - The invention relates to systems and methods for treating a fungal infection of the nail of an individual. In various embodiments, the methods include applying a device to at least one nail of the individual that is infected by a fungus. In various embodiments, the devices include at least one active electrode and at least one counter electrode, with the at least one counter electrode in contact with the individual.08-25-2011
20090143714Regulation of Mammalian Keratinous Tissue Using Skin and/or Hair Care Actives - Personal care compositions containing an active selected from the group consisting of 06-04-2009
20100268150METHOD AND APPARATUS FOR OPTOGENETIC TREATMENT OF BLINDNESS INCLUDING RETINITIS PIGMENTOSA - An apparatus for in vivo electroporating a plasmid into a retina of any eye includes a first electrode with a first polarity of voltage placed in contact with a cornea of the eye, a second electrode with an opposite second voltage at least in part behind the retina, and a pulsed voltage source for providing a pulsed DC voltage with an optimized field strength amplitude, frequency, number of pulses, group repetition rate and duration of pulse and group repetition, which are optimized for transfection of the channelrhodospsin-2 (ChR2) gene into the retinal ganglion cells. An in vivo method for treating retinal ganglion cells in an eye without use of viral transfection includes the steps of nonviral in vivo delivering a channelrhodospsin-2 (ChR2) gene to target the specific (retinal ganglion) cells of a retina by intravitreous injection of plasmid DNA, electroporating the plasmid into the retina and use of image intensification device for stimulating the retinal ganglion cells with ambient lighting conditions.10-21-2010
20090005723Combination iontophoresis and detoxifying device and methods for use - A device for imparting a combination of therapies to a user's body or body parts has a first battery-powered array submerged into a liquid contained in a first reservoir and a second battery-powered array submerged into a liquid contained in a second reservoir. Each array has one or more degradable electrodes that release ions into the liquid in the reservoir. The electrodes can be copper, zinc, steel, silver, nickel, or a combination thereof. The solution in the reservoir may contain positively or negatively charged medicament ions. During a therapy session, the device is operated in one or both of an electrolysis mode and an iontophoresis mode. Direct current is applied to one or more of the electrodes depending on the mode selected and other session parameters. The device uses a current and voltage regulator to deliver a regulated amount of current through the arrays regardless of the conductivity of the liquid, and electronic circuitry is used to control the duration, polarity, electrode choice, and intensity of the treatment. Excessive heat is dissipated with a heat sink.01-01-2009
20090012445Device and method for In-Situ tissue regeneration - This invention describes a novel method and a novel device for In-Situ replacement of abnormal biomaterials with regenerated new biomaterials having preserved its original functionalities. For example, a scalp tissue with lost hair cells is replaced with a new regenerated scalp tissue having hair cells. The device comprising of an intrusive means to remove or destroy abnormal biomaterials from a body of an individual and a regenerative means to stimulate function-recognitive biomaterials in the body in places where was removed abnormal biomaterials, and then use the stimulated function-recognitive biomaterials to enable or to accelerate regeneration processes of new normally functional biomaterials. The described In-Situ biomaterial regeneration is performed without need of the use of the function-recognitive biomaterials harvested from other places in the body than from the places where were removed abnormal biomaterials.01-08-2009
20080319370Method and System for Transdermal Drug Delivery - The present invention relates to a method and a system for transdermal delivery of a physiologically active agent. The invention further relates to a method of treatment using the transdermal delivery system and the use of medicaments (12-25-2008
20090326436ELECTROPORATION TO DELIVER CHEMOTHERAPEUTICS AND ENHANCE TUMOR REGRESSION - A method is disclosed for disrupting capillary blood flow and trapping materials such as chemotherapeutic agents in undesirable tissue, including cells of a cancerous or non-cancerous tumor. The method involves the placement of electrodes into or near the vicinity of capillary vessels supplying blood to capillaries in the undesirable tissue, and application of electrical pulses causing capillary blood flow disruption. In some cases, the electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body's immune system. The process may further comprise monitoring blood flow and/or infusion of a material such as a chemotherapeutic agent or marker into the blood.12-31-2009
20090326438Method for sterilizing and disinfecting body tissues by ising iontophoresis and the medical device - An iontophoresis-based medical device comprising a positive electrode section, a negative electrode section, a power source supplying an electric current to the positive electrode section and negative electrode section and a controller controlling the current value and conduction time of the electric current, the iontrophoresis-based medical device for allowing the drug solution to permeate into a lesion based on ionphoresis obtained by conducting current between the positive electrode section and negative electrode section, wherein the positive and negative electrode section are respectively given a handleable stick shape, the positive electrode section is provided with a drug solution retainer which retains the drug solution and contacts with a lesion, and the negative electrode section is provided with a solution retainer which retains the solution and contacts with a part of the body in the vicinity of the lesion.12-31-2009
20090247934METHODS AND SYSTEMS FOR REDUCING INFLAMMATION BY NEUROMODULATION OF T-CELL ACTIVITY - Described herein are devices, systems and method of treating inflammation, including methods of treating a T-cell mediated disease. In particular, described herein are methods of treating inflammation including the steps of stimulating a subject's inflammatory reflex to inhibit the immune response and administering a T-cell modifying agent to modify the activity of splenic T-cells. Also described herein are systems for treating inflammation including an inflammatory reflex stimulation module and a T-cell response modifying module. The T-cell response modifying module typically modifies the response of splenic T-cells to enhance or otherwise regulate the effect of stimulation of the inflammatory reflex.10-01-2009
20090247933BALLOON CATHETER METHOD FOR REDUCING RESTENOSIS VIA IRREVERSIBLE ELECTROPORATION - Restenosis or neointimal formation may occur following angioplasty or other trauma to an artery such as by-pass surgery. This presents a major clinical problem which narrows the artery. The invention provides a balloon catheter with a particular electrode configuration. Also provided is a method whereby vascular cells in the area of the artery subjected to the trauma are subjected to irreversible electroporation which is a non-thermal, non-pharmaceutical method of applying electrical pulses to the cells so that substantially all of the cells in the area are ablated while leaving the structure of the vessel in place and substantially unharmed due to the non-thermal nature of the procedure.10-01-2009
20110224599COMBINATION OF AN OXIDANT AND A PHOTOACTIVATOR FOR THE HEALING OF WOUNDS - There is provided wound healing composition which comprises at least one oxidant, at least one photoactivator capable of actuating the oxidant and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin in association with a pharmaceutically acceptable carrier. In addition, a method of topically treating wounds using at least one oxidant and at least one photoactivator capable of activating the oxidant followed by illumination of said photosensitizer is disclosed.09-15-2011
20090024075Method and Device for Treating Abnormal Tissue Growth With Electrical Therapy - This invention relates generally to the electrical treatment of malignant tumors and neoplasms by applying a voltage to affected tissue. Devices and various adaptations therein are described for use in electrical therapy. Additionally, various chemotherapeutic agent and radiation therapies are described which may be advantageously used in conjunction with electrical therapy to ameliorate cancer.01-22-2009
20080306431METHODS OF REDUCING SURGICAL COMPLICATIONS IN CANCER PATIENTS - A method of treating irradiated tissue, such as for revascularizing and preventing or reducing wound healing complications in a human or other animal subject having cancer. The method comprises administering to the irradiated tissue a therapeutic composition comprising one or more of platelet rich plasma, platelet poor plasma or platelet concentrate. In some embodiments the complications sought to be prevented and/or reduced can include: fibrotic tissue, prolonged would drainage, hematomas, seromas, fistula formation infection, pain, poor coloration, deficient vascularity, and desensitization in or around the irradiated site.12-11-2008
20090198173Light Emitting Device for use in Therapeutic and/or Cosmetic Treatment - An ambulatory device for use in therapeutic and/or cosmetic treatment has a localised light source such as an LED (e.g. 08-06-2009
20110144565COMBINATION OF A TILIROSIDE AND A PEPTIDE - The invention relates to a combination including at least one bioflavonoid, in particular tiliroside, and at least one peptide, in particular palmitoyl Lysine-Valine-5 diaminohydroxybutyrate. The invention also relates to a cosmetic or dermatological composition containing said combination.06-16-2011
20110144564ENHANCED NONINVASIVE COLLAGEN REMODELING - A method and apparatus for treatment of skin or other tissue, using a source of thermal, electromagnetic radiation, electrical current, ultrasonic, mechanical or other type of energy, to cause minimally-invasive thermally-mediated effects in skin or other tissue which stimulates a wound-healing response, in conjunction with topical agents or other wound healing compositions, for application on the skin or other tissue which accelerate collagenesis, such as in response to wound healing. The dosage and time period of application of the compositions are adjusted to prevent external or surface tissue damage.06-16-2011
20110144563COSMETIC TREATMENT METHOD INVOLVING PHOTO-POLYMERIZATION OF A COMPOSITION - The present invention relates to a cosmetic treatment method comprising: a) depositing a composition on keratinous materials or on an artificial surface having relief that is based on that of keratinous materials, the composition being polymerizable under the action of a light stimulus; b) directing a light beam from a laser onto the composition, to cause biphotonic polymerization thereof.06-16-2011
20110144562Localized Pharmacological Treatment of Ocular Tissue Using High-Intensity Pulsed Electrical Fields - A high-intensity pulsed-electrical-field (HIPEF) apparatus treats ocular tissue within a localized portion of an eye with a pharmacological solution. To mitigate risk of damage to adjacent, healthy ocular tissue, the apparatus delivers the solution to only a portion of the eye and then alters the effectiveness of at least some of the solution delivered by applying a HIPEF. In some embodiments, for example, the apparatus delivers an inactive pharmacological solution and then activates at least some of the solution by applying a HIPEF to that solution. As the apparatus applies the HIPEF with high precision, the HIPEF only activates solution within select portions of the eye. In other embodiments, the apparatus delivers a pharmacological carrier encapsulating an active pharmacological solution and then penetrates the carrier by applying a HIPEF. Delivered with a high concentration, but low dose, the solution diffuses only to tissue within a localized portion of the eye.06-16-2011
20110230817DEVICES FOR LIGHT TREATMENT OF WOUNDS TO REDUCE SCAR FORMATION - An electromagnetic energy system configured to reduce scar formation associated with a skin wound includes: an electromagnetic energy source configured to generate an electromagnetic energy beam having a plurality of beam parameters; an optical energy conduit having a proximal and a distal end, said optical energy conduit coupled to said electromagnetic energy source at said proximal end; a handpiece coupled to the distal end of said optical energy conduit; and a memory, comprising predetermined, stored values of said plurality of beam parameters, said predetermined values of said beam parameters configured to reduce scar formation associated with a skin wound.09-22-2011
20120289884Fused Ring Diarylamino Photosensitizers for Phototherapy - The invention relates generally to optical agents and methods of using optical agents for biomedical applications, including phototherapy. Provided are methods of using diarylamino compounds having a fused ring backbone providing phototherapeutic agents, including Type 1 phototherapeutic agents. Optical agents of the invention enable a versatile phototherapy platform for treatment of a range of pathological conditions, including the treatment of cancers, stenosis and inflammation. The invention further provides preparations and formulations comprising the diarylamino optical agents and related methods of making and using diarylamino optical agents in an in vivo or ex vivo biomedical procedure.11-15-2012
20090192437WEARABLE PHOTOACTIVATOR FOR OCULAR THERAPEUTIC APPLICATIONS AND USES THEREOF - The invention provides a wearable device for delivery of light of a desired wavelength and power to the cornea of a subject. The device includes a frame for attachment of a light source housing which includes a light source and a lens positioned in the housing to allow light to be directed to the eye of the subject, and the light source is operably linked to a power source. The invention provides method for the prevention and treatment of ocular disease including infection, neoplasia, and corneal dystrophies. The device of the invention can be used in conjunction with photoactive therapeutic agents.07-30-2009
20110230816Gels for Transdermal Delivery - The present disclosure provides hydrogels that are suitable for drug delivery. In embodiments, hydrogels of the present disclosure may be used for transdermal delivery of bioactive agents, including drugs. The hydrogels of the present disclosure may also be useful as conductive compositions for use with electrodes.09-22-2011
20090204059METHOD AND APPARATUS FOR SKIN ABSORPTION ENHANCEMENT AND TRANSDERMAL DRUG DELIVERY - A system for enhancing absorption of a substance to be provided on a region of a patient's skin, includes a probe configured to provide the substance to the region of the patient's skin, the probe including a flexible tape with a plurality of cavities, and with an electrically conductive element, such as a conductive wire, provided at one end of each of the cavities. A substance holding material, such as gauze stripes, temporarily holds the substance to be provided on the region of the patient's skin, the substance holding material being provided in each of the cavities. A pulse generator generates a sequence of bursts of electrical pulses to the electrically conductive elements provided within the cavities, so as to provide the bursts of electrical pulses to the region of the patient's skin.08-13-2009
20080262411DYNAMIC NERVE STIMULATION IN COMBINATION WITH OTHER EATING DISORDER TREATMENT MODALITIES - A method for the treatment of obesity or other disorders by electrical activation or inhibition of nerves is disclosed. This activation or inhibition can be accomplished by stimulating a nerve using an electrode. The method further comprises performing a surgical procedure and/or administering a weight loss drug.10-23-2008
20080262414SINGLE USE APPLICATOR CARTRIDGE FOR AN ELECTROKINETIC DELIVERY SYSTEM AND METHOD FOR SELF ADMINISTRATION OF MEDICAMENTS - An applicator cartridge for use with a device for electrokinetically delivering a medicament to a treatment site, the cartridge including: an applicator head including an active electrode, and a conductive path extending between a pair of electrical contacts, wherein the electrical contacts electrically engage respective contacts on the device when the cartridge is inserted into the device; a matrix support surface of said applicator head adjacent the active electrode; a matrix attached to the matrix support surface and in contact with the active electrode, the matrix having an exposed surface adapted to be applied to the treatment site; a medicament or a medicament and an electrically conductive carrier carried by said matrix; a removable lid covering the exposed surface of the matrix and sealed to the applicator head, the lid is conductively coupled to the applicator head and completes the conductive path on the applicator head, wherein removal of the lid breaks the conductive path.10-23-2008
20080262413Method For Supplying Oxygenated Water To Promote Internal Healing - Oxygenated aqueous fluids are provided by passing aqueous hydrogen peroxide through a device containing a hydrogen peroxide decomposition catalyst. The oxygenated fluid is then used to elevate oxygen tension in a patient in need thereof.10-23-2008
20080262412Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power - The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.10-23-2008
20120078160METHOD AND APPARATUS FOR CANCER THERAPY - Disclosed herein are methods and apparatus for treating bladder cancer. Example apparatus include a laser or other source that generates visible or near-infrared radiation and a cytoscope to deliver and apply the radiation to a treatment site, such as the urothelial surface of the bladder. The radiation alters the permeability of at least one layer of the bladder wall, allowing more efficacious administration of chemotherapeutic or anticancer agent to the bladder lumen during or after application of the radiation. Permeability of the bladder wall may be altered by damaging suburothelial blood vessels, such as those of the lamina propria of the bladder wall, or by damaging the urothelium and suburothelial blood vessels of the bladder in a patient with bladder cancer. Damage to the urothelium induced by the radiation may be of a continuous or discontinuous nature. Treatment may also cause regression or destruction of (pre)malignant tissue in the urothelium and suburothelium.03-29-2012
20090005722Skin-contacting-adhesive free dressing - A dressing having a flexible sleeve shaped to accommodate a substantially cylindrical body portion, the sleeve having a lining which is substantially non-adherent to the body part being bandaged and having a peripheral securement means which attaches two peripheral portions to each other without those portions being circumferentially adhered to the sleeve portion.01-01-2009
20090204058Device For Removing Deleterious Charged Molecules From Brain Tissue - Methods and devices for removing cationic glutamate or anionic aluminum complexes from brain tissue by applying a voltage to the brain tissue.08-13-2009
20090204057METHOD AND DEVICE FOR PHOTODYNAMIC THERAPY - The present invention relates to a photodynamic therapy method and uses thereof for treating an individual in need thereof, comprising administering a photosensitizer to an individual and activating the photosensitizer with a chemiluminescent light source, and/or a light-emitting diode light source, wherein the light source is in dermal contact with the individual. The present invention also relates to a device for photodynamic therapy comprising a permeable reservoir, for containing a photosensitizer formulation for skin application, the device is adapted to deliver the photosensitizer to the individual. The present invention also relates to a device for photodynamic therapy, comprising a permeable reservoir for containing a photosensitizer formulation for skin application and a light source. The light source is a chemiluminescent light source or a light-emitting diode light source and the device is adapted to deliver the photosensitizer to the individual and to irradiate a part of an individual to activate the photosensitizer.08-13-2009
20090204056CONSTANT CURRENT TREATMENT DEVICE - The present invention provides a device for treatment of a nail condition comprising, at least one active electrode disposed on the nail, at least one counter electrode, at least one power source for providing power to the device, wherein the at least one power source is electrically coupled to the at least one active electrode and the at least one counter electrode; a controllable voltage converter coupled to the at least one power source; and a sensing means coupled to the nail and to the controllable voltage converter, wherein the sensing means is configured to facilitate adjustment of the output voltage of the power source according to the nail resistance to facilitate providing a constant current to the nail with high efficiency. The present invention is also directed to a method of providing a constant current to treat a nail condition.08-13-2009
20090209899DELIVERY SYSTEM AND PROCESS - A delivery system, including: a material for storing molecules and/or nanoparticles by substantially binding said molecules and/or nanoparticles to said material; means for applying an electric field to said material to release said molecules and/or nanoparticles; and means for applying an ultrasonic signal to said material to transport said molecules and/or nanoparticles through said material to a surface for delivery to an entity.08-20-2009
20090221953COMPOSITION COMPRISING PROTEIN-LIPOSOME COMPLEX FOR IONTOPHORESIS - Provided is a composition for iontophoresis comprising a negatively-charged protein-liposome complex, in which the protein-liposome complex is formed of a negatively-charged protein and a cationic liposome. Such may provide a composition capable of efficiently delivering a protein having a large molecular weight intradermally and inducing an immune response effectively by iontophoresis.09-03-2009
20090221952Device for Transdermal Preparation - To provide an easily producible mass-production type transdermal drug device having a structure that a dissolution liquid and a drug can be mixed by simple operations. The device comprises an electrode holder (09-03-2009
20090221951IONTOPHORESIS DEVICE AND ELECTRIC POWER SOURCE FOR AN IONTOPHORESIS DEVICE - A drug may be administered in accordance with a daily living pattern of a patient and/or a circadian rhythm of the drug.09-03-2009
20120197180Drug Delivery from Electroactive Molecularly Imprinted Polymer - A device delivers a chemical or biological agent, the device comprises an imprint molecule (IM) to be delivered by the device; an electroactive molecularly imprinted polymer (EMIP) imprinted with the imprint molecule, the EMIP having a plurality of binding sites capable of binding the imprint; and an electric potential producing member (EPM), the EPM being capable of producing an electric potential between the EPM and the EMIP; whereby when the EMIP has a predetermined density of imprint molecule bound at the binding sites, and whereby when a sufficient potential is produced between the EPM and the EMIP, the imprint molecule is released from the binding site and thereby delivered by the device.08-02-2012
20090247932Method for the treatment of skin tissues - A method for treating skin tissues, the skin tissues defining an epidermal layer and a sub-epidermal layer, the epidermal layer defining a skin surface and the sub-epidermal layer extending from the epidermal layer substantially opposite to the skin surface, the method comprising: positioning a radiation source outside of the skin tissues at a predetermined distance from the skin surface; powering the radiation source so as to produce infrared radiation having a predetermined spectrum and a predetermined power; and irradiating the sub-epidermal layer with the infrared radiation through the epidermal layer, the predetermined spectrum and the predetermined power being such that the infrared radiation is absorbed to a larger degree in the sub-epidermal layer than in the epidermal layer.10-01-2009
20090240188Subdermal material delivery device - A method may include placing a first device on a first side of a skin portion of a subject and transferring a material through the skin portion of the subject from the first device to a subdermal second device disposed on a second side of the skin portion of the subject.09-24-2009
20090254018Electrode assembly for freezing-type iontophoresis device - An iontophoresis device capable of stably holding a drug during a storage period and of transdermally administering the drug to an organism at a high transport number during use. The iontophoresis device includes an electric power source. A first electrode assembly may be electrically coupled to the electric power source to store and transdermally administer an ionic drug to an organism via iontophoresis. The first electrode assembly stores the ionic drug at a temperature less than or equal to zero degrees Celsius and administers the ionic drug at a temperature greater than zero degrees Celsius. A second electrode assembly may be electrically coupled to the electric power source as a counter electrode to the first electrode assembly.10-08-2009
20100274175METHOD AND APPARATUS FOR SKIN ABSORPTION ENHANCEMENT AND TRANSDERMAL DRUG DELIVERY - A method and apparatus for enhancing absorption of a substance to be provided on a region of a patient's skin, includes outputting, by an electronic burst pulse generator, bursts of electronic pulses to the patient's skin, wherein the electronic pulses are generated by an electronic pulse generator. The method and apparatus also includes outputting, by a mechanical burst pulse generator, bursts of mechanical vibrations to the patient's skin at the same time the electronic pulses are applied to the patient's skin. The bursts of electronic pulses are output at a first burst rate, and the mechanical vibrations are output as bursts of vibrations at a second burst rate.10-28-2010
20100179469Organic Light Emitting Diode Phototherapy Lighting System - A lighting system includes a plurality of organic light emitting diode (OLED) devices. By selecting the plurality of OLED devices, or by selectively controlling the plurality of OLED devices, the color characteristics of the lighting system can be tuned. The lifespan of the lighting system can be improved.07-15-2010
20090018485CONTROL OF MICROORGANISMS IN THE SINO-NASAL TRACT - Disclosed are methods and apparatus for safe, simple and effective broad-spectrum treatments of chronic rhinosinusitis and other common and less common infections of the sino-nasal tract which may implicate not only a wide range of bacterial species but also fungi and viruses. Electromagnetic radiative energy including visible, and optionally, thermal RF, microwave or other longer wavelengths, is applied to target internal surfaces of the sino-nasal tract to destroy or incapacitate superficial microorganisms without the use of antibiotics. The treatment can be controlled to permit regrowth of healthy microflora. A handheld energy applicator has a light output head receivable into, or engageable with, the treatment subject's nostril which may be provided with extensions to reach the sinuses. Useful embodiments of the invention include pretreatment of target sino-nasal surfaces with a photosensitizing agent such as an oxidizing agent or a complementary stain. For example methylene blue can be used with orange or red light. The combination treatment of photosensitizer and application of visual wavelength energy provides a flexible treatment regimen which enables low concentrations of stains to be employed, minimizing aesthetic problems.01-15-2009
20100152645Facial Hair-Growth Device and Facial Hair-Growth System - Compared to a conventional halogen lamp and optical filter, wavelength range of a light is narrowed, throughput of a desired wavelength range is increased, and irradiation of a light of a different wavelength range is enabled. The present apparatus for facial treatment and hair restoration is a combination of a light source means, which is a light source of a monochromatic light of an ultra narrow bandwidth having a half bandwidth of 10 nm or less emitted from a monochromatic LED light source, a monochromatic laser diode light source, or a laser light source, and a diffusion means. Specifically, in a case where the LED light source is used, the apparatus includes a bandpass filter for focusing the wavelength range of each light emitted from the light source and a diffusion lens for diffusing a light which passed through the filter and has an ultra narrow bandwidth with a half bandwidth of 10 nm or less.06-17-2010
20090299265Electrode Assembly for Iontophoresis Having Shape-Memory Separator and Iontophoresis Device Using the Same - An electrode assembly for iontophoresis including an electrode coupled to an electric power source device having a same polarity as that of the ionic drug in the electrode assembly, an electrolyte solution holding portion holding an electrolyte solution by being impregnated with the electrolyte solution, the electrolyte solution holding portion being placed adjacent to the electrode, a first ion exchange membrane operable to substantially pass ions having a polarity that is same as a polarity of the ionic drug and substantially block ions having a polarity that is opposite the polarity of the ionic drug, the first ion exchange membrane being placed adjacent to the electrolyte solution holding portion, a drug solution holding portion holding the ionic drug by being impregnated with the ionic drug, the drug solution holding portion being placed adjacent to the first ion exchange membrane, a second ion exchange membrane operable to substantially pass ions having a polarity that is opposite the polarity of the ionic drug and substantially block ions having a polarity that is the same as the polarity of the ionic drug, the second ion exchange membrane being placed adjacent to the drug solution holding portion, and a shape-memory separator capable of being transformed between a first and a second configuration to respectively allow passage of a substance and blocking of the substance, the shape-memory separator placed adjacent to at least one surface of the first ion exchange membrane.12-03-2009
20100262067Method for Treatment of Neoplastic Cells in the Prostate of a Patient - An apparatus and a method for treatment of benign prostatic hyperplasia are disclosed. The apparatus includes an applicator piece carrying a set of electrodes shaped and positioned to create a substantial electric field in the volume of hyperplasia and a pulse generator adapted for delivery of electrical pulses above the upper electroporation limit for the neoplastic cells. The amplitude, duration and number of the electrical pulses are generally selected to cause necrosis of a significant fraction of the volume of benign prostatic hyperplasia. The apparatus may include a high frequency system for heating the prostatic tissue and a cooling system for cooling the urethra. The combined action of heating and cooling may increase the temperature of the prostate cells to 45 degrees C. to 55 degrees C., while keeping the urinary tract at a temperature 15 degrees C. to 20 degrees C. This temperature distribution can increase the selectivity of the treatment by increasing susceptibility of the neoplastic cells to the electroporation treatment and decreasing it for the normal urethral tissues.10-14-2010
20100262066ELECTRONIC CONTROL OF DRUG DELIVERY SYSTEM - In an exemplary embodiment, a drug delivery device for driving an electrotransport current through a body surface of a user is provided. The device includes a patch with two electrodes and one or more reservoirs storing a therapeutic agent. The one or more reservoirs release the therapeutic agent into the body surface of the user when the reservoirs are positioned over the electrodes to form an electrical path for the electrotransport current. The device includes a controller which controls a controllable power supply to drive the electrotransport current through the body surface of the user in a predetermined profile.10-14-2010
20110060269METHOD FOR KILLING CELLS USING PHOTOCATALYTIC TITANIUM DIOXIDE PARTICLES - Photocatalytic titanium dioxide particles are disclosed having improved dispersibility into an aqueous solvent not only under neutral physiological conditions in vivo but also over a wide pH range, and improved cell affinity and cell uptake property. The photocatalytic titanium dioxide particles comprise particles comprising photocatalytic titanium dioxide and a cationic hydrophilic polymer modifying surfaces of the photocatalytic titanium dioxide particles, wherein the hydrophilic polymer is bonded to the photocatalytic titanium dioxide particles. The particles are very useful for medical applications, such as destruction of cancer cells, e.g., when administered to a mammal the titanium dioxide particles are taken up by cells of the mammal, and if then irradiated with UV light the particles kill the cells via photocatalytic degrading capability.03-10-2011
20110060267ULTRAVIOLET IRRADIATION TO TREAT CORNEAL WEAKNESS DISORDERS - Methods of strengthening the biomechanical properties of the cornea by exposing the cornea to ultraviolet light in the presence of a photoinitiator are described. These methods can be used to treat keratoconus. They can also be used to treat ectasia following a surgical procedure, or to strengthen the cornea prior to a surgical procedure.03-10-2011
20110130704COMBINATION OF A LIGHT RAY AND A LIPASE-BIOCONVERTIBLE COMPOUND FOR IMPROVING SKIN AND/OR HAIR APPEARANCE - The present invention relates to a cosmetic method intended in particular to improve the appearance of the skin and/or hair comprising the simultaneous and/or sequential administration: 06-02-2011
20100228180Power Source Electrode Treatment Device - The present invention provides a powered treatment device comprising at least one power source for supplying electrical energy to the device, and wherein at least one component of the power source is also configured as a power source treatment device electrode to facilitate electrical contact with a body region. In an embodiment wherein one component of the power source is configured as a power source treatment device electrode, the powered treatment device may further comprise at least one non-power source device electrode of opposite polarity from the power source treatment device electrode, wherein the at least one non-power source device electrode is electrically coupled to the at least one power source to facilitate electrical contact with a body area.09-09-2010
20100228181USE OF GREEN LIGHT TO ACTIVATE L-AMINO ACID OXIDASE - The present invention relates more specifically to the use of a source of green light for activating L-amino acid oxidase in the presence of at least one substrate of this enzyme in order to stimulate the energy metabolism of the cells of the skin, to stimulate their replacement and thus to improve the appearance of the skin and hair, in particular to prevent and/or treat cutaneous signs of ageing of the skin and hair.09-09-2010
20090076437Drug Delivery from Electroactive Molecularly Imprinted Polymer - A device delivers a chemical or biological agent, the device comprises an imprint molecule (IM) to be delivered by the device; an electroactive molecularly imprinted polymer (EMIP) imprinted with the imprint molecule, the EMIP having a plurality of binding sites capable of binding the imprint; and an electric potential producing member (EPM), the EPM being capable of producing an electric potential between the EPM and the EMIP; whereby when the EMIP has a predetermined density of imprint molecule bound at the binding sites, and whereby when a sufficient potential is produced between the EPM and the EMIP, the imprint molecule is released from the binding site and thereby delivered by the device.03-19-2009
20100210996METHOD FOR LASER CORRECTION OF REFRACTIVE ERRORS OF AN EYE WITH A THIN CORNEA - The present invention relates to a method of altering the refractive properties of the eye, the method including applying a substance to a cornea of an eye, the substance configured to facilitate cross linking of the cornea, irradiating the cornea so as to activate cross linkers in the cornea, and altering the cornea so as to change the refractive properties of the eye.08-19-2010
20100210995SYSTEMS AND METHODS FOR TREATING SUPERFICIAL VENOUS MALFORMATIONS LIKE SPIDER VEINS - Systems and methods treat superficial venous malformations, such as spider veins. The systems and methods distribute a reactive agent, e.g., a light-reactive agent such as talaporfin sodium or verteporfin, at or near an inner wall of a vein. The systems and methods activate the reactive agent by applying energy, e.g. non-thermal light energy at a wavelength that activates the reactive agent to cause localized injury to the inner wall of the vein.08-19-2010
20100210994DELIVERY OF THERAPEUTICALLY/DERMATOLOGICALLY ACTIVE SPECIES INTO THE SKIN VIA ELECTROPORATION - A regime or regimen for treating a skin disease, disorder or condition afflicting a patient in need thereof includes forming at least one micropore to a predetermined depth through a surface of the afflicted skin of such patient; positioning at least a first electrode on the surface of the afflicted skin electrically coupled to the at least one micropore and a second electrode on the surface of the afflicted skin spaced apart from the first electrode; applying an electrical voltage from the first and second electrodes to produce a desired electroporation in the skin, and further including the step of delivering a biologically active species to the afflicted skin at the at least two micropores formed therein, wherein the biologically active species is therapeutically/dermatologically active against the skin disease, disorder or condition.08-19-2010
20120035528LOW-PERMEABILITY, LASER-ACTIVATED DRUG DELIVERY DEVICE - An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.02-09-2012
20110112462PHARMACEUTICAL AGENT DELIVERY IN A STIMULATING MEDICAL DEVICE - A stimulating medical device comprising a stimulating assembly implantable proximate to nerve cells of a recipient having at least one agent delivery port and a plurality of electrical contacts; an electrical stimulation controller configured to generate electrical stimulation signals for application to a first population of the nerve cells via one or more of the plurality of electrical contacts; a pharmaceutical agent source configured to provide a pharmaceutical agent to the at least one delivery port for application to a second population of the nerve cells; and a pharmaceutical agent controller configured to control one or more of the pharmaceutical agent source and the at least one delivery port to cause selective application of the pharmaceutical agent to the second population of nerve cells.05-12-2011
20110112464MESO-SUBSTITUTED PORPHYRINS - Meso-substituted porphyrins of general formula (I)05-12-2011
20110112461Textile Product - Improvements applied to a textile product, and more particularly wherein the improved product is a woven textile product—fabric containing bioceramic microparticles embedded into the fibers thereof with high capacity of irradiation in the infrared region, provided to be used both in humans and animals, more particularly the invention is related to a textile product containing bioceramic microparticles with high capacity of infrared irradiation which, in contact with the heat of the human body, is capable of transmitting infrared radiation in the range between 3 μm and 14.8 μm, preferentially in the 14.8 micron range, said infrared radiation at this wavelength being capable of regulating the blood microcirculation, as the result of its high protection, the blood microcirculation being the nervous center of human and/or animal metabolism.05-12-2011
20100222734Double-sided patch - The present invention provides a double-sided patch comprising a first side and a second side, wherein each of the first side and the second side of the double-sided patch is configured as a treatment patch. Furthermore, the present invention provides a double-sided patch, wherein each side of the double-sided patch shares at least one common patch component with the other side of the double-sided patch.09-02-2010
20100210993SKIN TREATMENT APPARATUS FOR PERSONAL USE AND METHOD FOR USING SAME - An apparatus for personal skin treatment includes an RF generator and an applicator with at least a pair of electrodes mounted on the distal end of the applicator. The electrodes are configured for applying an RF voltage to a subject skin. The RF voltage generator supplies the electrodes with the RF voltage. The applicator includes a source of illumination illuminating the treated skin segment.08-19-2010
20100204637IONTOPHORETIC SYSTEM FOR TRANSDERMAL DELIVERY OF ACTIVE AGENTS FOR THERAPEUTIC AND MEDICINAL PURPOSES - An embodiment of a system includes a power source and at least two electrode assembles. The power source that an output current that alternates between a maximum current value and a minimum current value; a pair of electrode assemblies. Each electrode assembly is configured to be held in contact with a skin layer of a user. Additionally, each electrode assembly includes an electrode that is coupled to the power source to receive the output current from the power source. At least one of the electrode assemblies in the pair includes a medium that carries an active agent having a charge, the medium being provided on the at least one electrode assembly to enable the output current to repel the active agent into the skin layer for a duration in which the output current has a polarity that is the same as a polarity of the active agent.08-12-2010
20100094196Systems and methods for delivering agents into targeted tissue of a living being - The systems basically comprise a delivery system for accessing the targeted tissue within the living being and introduction of at least one agent at select locations in the into the myocardium and other select tissues. The delivery systems are arranged to access the tissues of the heart. One or more of the systems can be utilized during transluminal, transthoracic and direct surgical access procedures. Where appropriate, for example in the case of intraventricular access, portions of the system are steerable to properly orient the device. The instruments may pierce the heart tissue and create channels extending from the endocardium, the epicardium, or the cardiac vessels. When tissue penetration is utilized, the device may include a feature to control the depth of penetration. To minimize bleeding through the channels the device can dilate small initial punctures that later contract down after device removal. When the formation of channels is required, this can be achieved, by way of example, with a rotary-tipped device, pressurized fluid jet devices, vibratory instruments and piercing needle-like tip devices. The system may utilize some form of mechanical action or application of energy (e.g. electrical, sonic, thermal, optical, pressurized fluid, radio frequency (RF), nuclear) in the process. The mechanical action or energy application may affect the surroundings tissues at a distance from the device. The agent delivered to the tissue may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc.04-15-2010
20110130706SEQUENTIAL BODY SURFACE TREATMENT - The present methods and systems provide treatment of a preselected body surface by injuring a portion of the body surface, optionally applying a composition such as a pharmaceutical agent to the injured portion of the body surface, and selection of a further portion on the body surface for the same or different injury and optional contacting with the same or different composition, wherein the further portion has a preselected geometry with respect to the first injured portion. The repetition of the selection, injury, and optional exposure to a composition with respect to successive portions of the body surface, optionally under partial or total computer control, provides efficient treatment of the body surface pursuant to the objective of regeneration, remodeling, resurfacing, restoration, follicular neogenesis, neocollagenesis, stem cell recruitment, activation, or differentiation, reepitheliazation, wound healing, or any other desired biological or physical modification.06-02-2011
20110237999SYSTEMS AND METHODS FOR APPLYING AND MONITORING EYE THERAPY - Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye 09-29-2011
20090326435Systems and methods for treating superficial venous malformations like varicose or spider veins - Systems and methods treat superficial venous malformations, such as varicose or spider veins. The systems and methods distribute a reactive agent, e.g., a light-reactive agent such as talaporfin sodium or verteporfin, at or near an inner wall of a superficial feeder vein leading to the varicose or spider veins. The systems and methods activate the reactive agent by applying energy, e.g. non-thermal light energy at a wavelength that activates the reactive agent to cause localized injury to the inner wall of the superficial feeder vein to close the feeder vein to interrupt blood flow to the varicose or spider veins, which consequently shrink.12-31-2009
20100198134HAIR REMOVAL APPARATUS FOR PERSONAL USE AND THE METHOD OF USING SAME - Hair or partial hair removal system and hair growth deterrent that includes mechanical process for cutting, plucking or shaving hair follicles, along with pre and/or post skin treatment techniques. The skin treatment techniques can include the application of energy to the skin surface before, after and/or during the application of the mechanical process. Such techniques include the application of heat and/or energy from illumination sources and/or RF emitters. Further skin treatment techniques include the application of solutions before, after and/or during the mechanical process and/or the application of heat and/or energy. Overall, the system operates to treat an area of skin to facilitate the removal of all or a portion of hair, retard further growth, and recovery of skin surface.08-05-2010
20090326437DEVICE FOR TREATING THE SKIN - A device for treating the skin, for instance for removing body hair. The device includes a working head, which includes an irradiating device for irradiating the skin surface to be treated, preferably by means of light; a contact surface surrounding the irradiating device for supporting the working head on the skin surface; and a safety device for controlling the irradiation and/or for providing a safety signal. The safety device includes a recording device for recording the support of the working head on the skin surface. The contact surface defines a bell-like pressure and/or sound chamber and the recording device encompasses an impermeability sensor device for determining the over-pressure and/or sound impermeability of the pressure and/or sound chamber.12-31-2009
20120245508SYNTHESIS OF CHLORINS AND PHORBINES WITH ENHANCED RED SPECTRAL FEATURES - The present invention provides compounds of the general Formula DI:09-27-2012
20090240190Iontophoresis Device and Method for Producing Same - To provide an easily producible mass-production type iontophoresis device having a structure that a dissolution liquid-storing container is integrated with an iontophoresis electrode, a dissolution liquid and a drug can be mixed by simple operations, and it is free from a risk of leakage of electricity. The device comprises an electrode film having an electrode layer (09-24-2009
20090318849Device and Method for the Ablation of Fibrin Sheath Formation on a Venous Catheter - An indwelling venous catheter and method capable of destroying undesirable cellular growth is provided. The catheter includes a shaft having at least one lumen and adapted to be placed inside a vein for long term use. A plurality of electrodes are positioned near a distal section of the shaft and are adapted to receive from a voltage generator a plurality of electrical pulses in an amount sufficient to cause destruction of cells in the undesirable cellular growth that have grown around the shaft. In one aspect of the invention, a probe is configured to be removably insertable into the at least one lumen and the electrodes are positioned near the distal section of the probe.12-24-2009
20090318848MEDICAL DEVICES EMPLOYING CONDUCTIVE POLYMERS FOR DELIVERY OF THERAPEUTIC AGENTS - In accordance with one aspect, the invention relates to medical devices which comprise at least one reservoir, a therapeutic-agent-containing region disposed within the reservoir and an electrode comprising a conductive polymer. The devices of the invention are configured such that a rate of release of the therapeutic agent from the reservoir changes upon a change in the oxidation state of the conductive polymer.12-24-2009
20110130703SYNCHRONIZED WATER AND PRODUCTION AND USE THEREOF - A synchronized water is disclosed, in which all single water molecules at the same time are arranged in an identical way to a stable homogeneous microstructure, wherein said synchronized water in a distilled condition and at atmospheric pressure has a) a density of from 0.997855 to 0.998836 g/ml at 22° C., b) a water temperature at the freezing point of from −6.7° C. to −8.2° C., c) a melting point of from 0.1° C. to 0.2° C., d) a surface tension of from 72.3 to 72.7 dyn/cm at 22 and e) a dielectric constant of from 82.4 to 82.6 F/m, as well as a method for preparation thereof and different uses thereof.06-02-2011
20090318847Polyamine enhanced formulations for triptan compound iontophoresis - A patch and compositions for iontophoresis of triptan compounds are described.12-24-2009
20090318845Iontophoresis Device and Method for Producing Same - To provide an easily producible mass-production type iontophoresis device having a structure that a dissolution liquid-storing container is integrated with an iontophoresis electrode, a dissolution liquid and a drug can be mixed by simple operations, and it is free from a risk of leakage of electricity. The device comprises an electrode film having an electrode layer (12-24-2009
20080312580CURRENT CONCENTRATION SYSTEM AND METHOD FOR ELECTROKINETIC DELIVERY OF MEDICAMENTS - An electrokinetic apparatus to apply medicament to a treatment site of a mammalian user, the apparatus including: a flux concentrator including an active electrode and a counter electrode adapted to be applied to the surface of a toenail or fingernail of the user, and a medicament matrix adjacent the active electrode and arranged to be sandwiched between the active electrode and nail.12-18-2008
20090143715Feedback control device for transcutaneous drug delivery and uses therefor - Provided herein is a device for altering a biological membrane in an individual comprising a means for delivering energy to the surface of the biological membrane, a means for monitoring a physiological state of the biological membrane during delivery of said energy, a means for modulating delivery of the energy to the biological membrane where the modulating is in response to a change in the monitored physiological state. Also provided is a device to control the permeation of substance across a biological membrane and methods for use of these devices.06-04-2009
20080281252Apparatus for Body Cavity Delivery with Medium, Body Cavity Leading-in and Ultrasound Block - The present invention generally relates to a medical apparatus. More particularly, the present invention relates to an apparatus for delivering a medium to body cavity of mammals including a human, especially to an apparatus for expanding rectum. Specifically, the present invention relates to the field of focused ultrasound treatment with a main purpose to provide an auxiliary device for ultrasound therapy applied to uterine myoma so as to avoid damage by ultrasound after focused within body. Therefore, the present invention provides an apparatus for blocking ultrasound, comprising (1) lead-in means for entering into said body cavity; and (2) accommodation means for containing ultrasound blocking medium, which enwraps the lead-in means outside.11-13-2008
20120143119Delivery of Serotonin Receptor Antagonists By Microinjection Systems - In an aspect of the invention, serotonin receptor antagonist formulations are provided for subcutaneous, transdermal or intradermal delivery to a subject. In an embodiment, serotonin receptor antagonist formulations include ondansetron or ondansetron-containing formulations. In another embodiment, serotonin receptor antagonist formulations include palonosetron or palonosetron-containing formulations. In another aspect of the invention, microinjection devices are provided for delivering a serotonin receptor antagonist formulation to a subject.06-07-2012
20090105634Anodic Reservoir for Electrotransport of Cationic Drug - An electrotransport system for delivery of a cationic drug. The system has a donor anodic reservoir having an insoluble biocompatible polymeric anion source embedded in the reservoir. The anion source has precipitating anions that can precipitate out metal ions generated from sacrificial metal of the anode during electrotransport.04-23-2009
20110112463COMPOSITIONS AND METHODS FOR TREATING A NEURONAL INJURY OR NEURONAL DISORDERS - A method of improving the efficacy of denervated, quiescent, or dormant motor neurons includes expressing light sensitive G protein coupled receptors in the motor neurons, the light sensitive G protein coupled receptors modulating cellular activity in the motor neurons upon exposure to a wavelength of light and exposing the motor neurons expressing the light sensitive G protein coupled receptors to the wavelength of light.05-12-2011
20090069739METHODOLOGY FOR NON-SURGICAL FACIAL SCULPTING AND LIFT - Non-surgical methods and systems of facial restoration, and more particularly a multi-technique method utilizing tissue tightening, collagen shortening and remodeling with long term fillers to provide for non-surgical facial sculpting and lift are provided. The methods and systems address the predictable pattern of multi-layered volume loss of tissue from the skin to the bone as a result of aging.03-12-2009
20090069740PROTECTED DONOR ELECTRODES FOR ELECTRO-TRANSPORT DRUG DELIVERY - This invention provides new and novel devices and methods for administering donor ions to a mammalian subject, especially the delivery of alkali, alkaline earth, transition metal ions and simple anions (donor ions) to a body component, for example across a body or tissue surface such as skin or a mucosal membrane, or for delivery of donor ions directly to bodily fluids in a controllable and reproducible manner. In certain embodiments the device comprises a donor electrode that is a source of a donor ion; a protective architecture that is ionically conductive to the donor ion, configured for application to a skin surface and positioned to isolate the donor electrode from the skin surface; and a counter electrode assembly configured for application to a skin surface, where the counter electrode assembly comprises a counter electrode operably coupled to the donor electrode.03-12-2009
20090069738Electrode Structures Having Anti-Inflammatory Properties And Methods Of Use - Electrode structures for implantation include an electrode, an elastic backing attached to the electrode, and a sequestered drug on the backing or the electrode which is released to control and/or limit the growth of scar tissue. The elastic backing includes a tissue contacting side which contacts a tissue structure, and an exposed side away from the tissue contacting side. The electrode structure can be used to activate baroreceptors, and the backing is elastic and can stretch and retract with the tissue structure, for example the carotid sinus. The electrode and the sequestered drug can be positioned on the tissue contacting side so the drug is released near the electrode. The backing can be made from an insulating material and limit diffusion of the drug toward the exposed side, permitting scar tissue to grow near the exposed side to maintain positioning of the electrode.03-12-2009
20100312167Cosmetic Rejuvenation by Photodynamic Therapy - A PhotoDynamic Therapy (PDT) method is presented for cosmetic rejuvenation, which is exemplified by a two phase approach for treating facial and neck skin aging while minimizing damage to the underlying region of skin being treated. To obtain best results a combination of treatments are used. This includes applying photosensitizer and light energy for stimulating the collagen within the skin, thereby restoring the elasticity of skin. The treatment procedures take about six weeks consisting of impair(damage) and repair (recovery) sessions involving skin preparation by peeling, skin detoxification, application and distribution of photosensitizer to the skin, irradiation of pre-sensitized skin followed by removal of mask. Results of long lasting improvement, especially in comparison with most cosmetic treatments, are obtained upon completion of the series, with marked changes being observed after individual sessions, which provide added incentive to complete a treatment program. These results eliminate the need for repetitive treatments after the six week series, unlike most current approaches which require repeat sessions semi-annually or annually.12-09-2010
20130138032ANTICANCER AGENT DELIVERY SYSTEM USING pH-SENSITIVE METAL NANOPARTICLES - The present invention relates to a method for effectively delivering an anticancer drug into cancer cells by binding the anticancer drug to pH-sensitive metal nanoparticles so as to be separated from cancer cells. The pH-sensitive metal nanoparticles according to the present invention may be heated by photothermal therapy, thereby effectively killing cancer cells in conjunction with the isolated anticancer drug.05-30-2013
20130138033LASER ASSISTED SCLEROTHERAPY METHOD FOR TREATING VARICOSE VEINS - The present invention relates to a method for treating varicose veins, which comprises: pre-treating a target vein segment with a pulsed laser radiation having a wavelength of from 1400 to 2300 nm, thereby causing a substantial diameter reduction of the target vein segment;05-30-2013
20110172587METHOD AND SYSTEM FOR DRUG DELIVERY TO THE EYE - Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the patient's eye.07-14-2011
20110172586Treatment of Microbial Infections Using Hot and Cold Thermal Shock and Pressure - A method of treating microbial infections, which consists of the steps of sequentially and repeatedly irradiating the microbe with continuous or pulsed infrared radiation and continuous or pulsed cooling such that heat and cold alternatively penetrates to the site of the infection in order to inactivate the pathogen.07-14-2011
20110004148DEVICE FOR LOCAL INTRALUMINAL TRANSPORT OF A BIOLOGICALLY AND PHYSIOLOGICALLY ACTIVE AGENT - Provided herein is a drug delivery device and the method of us for the intraluminal controlled delivery of a biologically active agent comprising a dilating member comprising a proximal end and a distal end, and an inner surface and an outer surface, wherein a part of the outer surface of the dilating member is coated with a gold surface layer; a biodegradable substrate comprising the biologically active agent, wherein the substrate is covalently bonded to the gold surface layer by a gold-sulfur (Au—S—) bond; an electrical lead having a first end and a second end, the first end connected to the gold surface layer, wherein the electrical lead is configured to pass an electrical current to the gold surface layer; and wherein the controlled delivery and release of the sub strate comprising the biologically active agent is initiated by an electrical current reduction and cleavage of the Au—S bond.01-06-2011
20100331759CORROSION RESISTANT ELECTRODES FOR IONTOPHORETIC TRANSDERMAL DELIVERY DEVICES AND METHODS OF USE - Embodiments of the invention provide electrode assemblies and associated methods for the iontophoretic transdermal delivery of therapeutic agents. Many embodiments provide a corrosion resistant electrode for the iontophoretic transdermal delivery of various therapeutic agents. Such embodiments allow for the iontophoretic transdermal delivery of therapeutic agents such as iron compounds for prolonged periods without any substantial corrosion of the electrode, impedance increases or discoloration or irritation of the skin. Embodiments of the invention are particularly useful for the long term treatment of various chronic medical conditions such as iron deficient anemia.12-30-2010
20100331758IRREVERSIBLE ELECTROPORATION USING NANOPARTICLES - The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors. In embodiments, the methods comprise the use of high aspect ratio nanoparticles with or without modified surface chemistry.12-30-2010
20100331760BIODEGRADABLE IMPLANT FOR TREATING OR PREVENTING REPERFUSION INJURY - A biodegradable implant for iontophoretic therapeutic agent delivery is provided. The implant comprises a biodegradable battery and at least one biodegradable iontophoresis electrode assembly. The biodegradable battery comprises first and second biodegradable electrodes and a biodegradable polymer electrolyte layer between the first and second biodegradable electrodes. The biodegradable iontophoresis electrode assembly comprises a biodegradable iontophoresis electrode and a charged therapeutic agent. When the biodegradable battery is electrically connected to generate an electric current through the biodegradable iontophoresis electrode assembly, the charged therapeutic agent is delivered by iontophoresis to a target location. The charged therapeutic agent may be a scavenger for reactive oxygen species. The electrical connection of the biodegradable battery may be controlled remotely.12-30-2010
20110034855NONINVASIVE THERAPIES IN THE ABSENCE OR PRESENCE OF EXOGENOUS PARTICULATE AGENTS - Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.02-10-2011
20110034856DEVICE AND METHOD FOR ENHANCED WOUND TREATMENT - An apparatus for facilitating the healing of a wound on a limb of a body of a subject, including: (a) a wound treatment assembly having: (i) a sealing arrangement adapted to cover an area above the wound, and to contact and at least partially seal a volume from an ambient environment, and (ii) a vacuum mechanism fluidly communicating with the volume, and adapted to produce a sub-atmospheric pressure therein; (b) a muscle contraction device having at least first and second electrodes, each adapted to operatively contact the limb; (c) a control unit, adapted to connect to a power supply and operatively connected to each electrode, and further adapted to provide, via the electrodes, a sequence of electrical impulses to points associated with the limb, whereby muscle tissue associated with the points contracts to effect a localized increase in afferent and efferent flow of blood through blood vessels in the limb, the control unit being operatively connected to the assembly and further adapted to control an operation thereof.02-10-2011
20110034859IONTOPHORESIS PREPARATION FOR TREATING BREAST CANCER AND/OR MASTITIS - Provided is to enhance the therapeutic effect of an iontophoretic preparation for treatment of breast cancer or mastitis.02-10-2011
20110034857Implantable Fluid Delivery Apparatuses and Implantable Electrode - An electrode for an implantable prosthesis includes a flexible front end including one or more metal contacts and a back end including one or more metal contacts. The electrode has a cross-sectional shape along the electrode, and the cross-sectional shape has a discontinuity between the flexible front end and the back end. The cross-sectional shape does not have a substantially constant diameter and does not have a continuously growing diameter. The cross-sectional shape of the flexible front end is substantially smaller than the cross-sectional shape of the back end such that forces required to bend the flexible front end are less than forces required to bend the back end.02-10-2011
20110034854PDT ASSISTED VISION CORRECTION AND SCAR PREVENTION - A method and formulation are disclosed for improving the results of corneal refractive surgery, and generally reducing post-operative scarring and scarring arising from other traumas. In the vision examples, after completion of a procedure, including Photorefractive Keratotomy (PRK) or Laser-In-Situ Keratomileusis (LASIK), a photosensitizer or photosensitizer precursor is applied to the treatment site. After allowing sufficient time for the photosensitizers to accumulate among proliferating cells that occur as a result of ablation, radiation appropriate to activate the photosensitizers is administered to the treatment site. The photosensitizer is thus activated to destroy only those proliferating cells. In this way, proliferating tissue is eliminated and the cornea maintains the shape created during the surgery. As a result, instances of regression and the need for follow-up treatments, is minimized. This method is also useful for preventing post-surgical scarring that can lead to vision problems such as corneal haze. Likewise the method and formulations, presented here, are suitable for reducing post-operative scarring, and trauma cased scarring in general. For such scars, a photosensitizer or photosensitizer precursor is topically applied to the treatment site. After allowing sufficient time for the photosensitizers to attach to proliferating cells, radiation appropriate to activate the photosensitizers is administered to the treatment site. The photosensitizer is activated to destroy only those proliferating cells.02-10-2011
20110040235Multi-Modal Drug Delivery System - A device for the transdermal delivery of a therapeutic agent at a treatment site comprising a housing containing: a mechanical vibration element; a light source; a heating and/or cooling clement; a power source for powering said mechanical vibrational element, light source, and heating element; and an electronic control module.02-17-2011
20110040236MICRONEEDLE ROLLER - The invention provides a microneedle roller comprising a rotatable drum, the drum including a plurality of radially projecting microneedles, wherein the microneedles are provided in substantially linear arrays, each array being carried by a support, and each array being arranged in a substantially axial direction relative to the drum.02-17-2011
20110040237DRILL DEVICE AND METHOD FOR FORMING MICROCONDUITS - The present invention relates to methods and devices for formation of microconduits in tissue, particularly using an impedance sensing drill to form microconduits. One embodiment of the invention is an impedance sensing drill comprising a drilling assembly, a control module, mechanically connected to the drilling assembly for controlling the depth of drilling by the drilling assembly; and a sensor, electrically connected to the drilling assembly and control module for detecting a change in an electrical impedance of a material being drilled. Another embodiment is a method of forming a microconduit in a material, which comprises the steps of drilling into the material, monitoring an electrical impedance of the material, and stopping the drilling into the material when a change in the impedance is detected, thereby forming microconduit.02-17-2011
20110118652Device,system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject - A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more microjet applicators supported by the one or more substrates and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.05-19-2011
20090062722Drug sheet - A drug sheet includes a base fabric carrying a therapeutic agent containing an electrolytic drug component and applied to or impregnated into a skin-abutting surface of the base fabric. Small needle members carrying small needle-shaped protrusions are scattered on the skin-abutting surface so that the needle-shaped protrusions protrude from the skin-abutting surface. The needle members include a first group of needle members made of aluminum and provided on a first area of the skin-abutting surface, and a second group of needle members made of silver and provided on a second area of the skin-abutting surface. Due to a difference in standard electrode potential between the first and second groups of needle members, electric current flows between the first and second groups of needle members through skin when the needle-shaped protrusions are stuck in the skin. This improves the absorption rate of the drug component.03-05-2009
20090062719Enhanced PhotoDynamic Therapy with Immune System Assist - A photodynamic therapy (PDT) method to treat primary sites of hyperproliferative tissue and induce long term, tumor specific immunity for regression and eradication of distant metastases is disclosed. The improved treatment regimen comprises the partial or fractional application of PDT with several applications, spaced in time, to permit a patient's immune system to react to dead tissue generated by each fractional application. Once activated, the immune system can help reduce or eliminate secondary stage tumors and metastasis stage tumors.03-05-2009
20090062720Transdermal Methods and Systems for the Delivery of Corticosteroid Compounds - An integrated iontophoresis skin-worn patch and method for delivering a therapeutically effective amount of a corticosteroid drug compound in a systemically-safe and skin-safe manner for site-specific treatment of inflammation pain is disclosed.03-05-2009
20090062721IONTOPHORESIS DEVICE AND METHOD OF MANUFACTURING THE SAME - An iontophoresis device including an electrode assembly which holds a drug solution containing a salt of a first drug with an acid dissolved therein and has a polarizable electrode to be in contact with the drug solution, in which the polarizable electrode to which a second drug of the same kind as that of the first drug is adsorbed. A method may include adsorbing the second drug to the polarizable electrode; and then bringing the drug solution into contact with the polarizable electrode. As a result, the iontophoresis device is capable of suppressing a change in the pH value of the drug solution in the case where the drug solution containing the salt of the first drug with the acid dissolved is held in contact with the polarizable electrode.03-05-2009
20110245755Sacrificial Electrode Design and Delivery Species Suitable for Prolonged Iontophoresis Application Periods - A wearable iontophoresis device for the prolonged delivery of a positively charged pharmaceutical species from a salt formulation is disclosed that includes a readily oxidizable metal-based sacrificial anode in the form of a generally planar layer having a connecting area that has a width that is sufficient to insure complete consumption of the oxidizable metal wherein the anode is configured to have a minimum operating life of at least 6 hours under skin-safe conditions, and a drug delivery gel pad in electrical contact with said anode for accommodating a gel containing a positively charged pharmaceutical species in salt form formulated for transdermal delivery.10-06-2011
20110092882SYSTEMS AND METHODS FOR PATIENT INTERACTIVE NEURAL STIMULATION AND/OR CHEMICAL SUBSTANCE DELIVERY - Systems and methods for patient interactive neural stimulation and/or chemical substance delivery are disclosed. A method in accordance with one embodiment of the invention includes affecting a target neural population of the patient by providing to the patient at least one of an electromagnetic signal and a chemical substance. The method can further include detecting at least one characteristic of the patient, with the characteristic at least correlated with the patient's performance of an adjunctive therapy task that is performed in association with affecting the target neural population. The method can still further include controlling at least one parameter in accordance with which the target neural population is affected, based at least in part on the detected characteristic.04-21-2011
20110213294TRANSDERMAL METHODS AND SYSTEMS FOR THE DELIVERY OF ANTI-MIGRAINE COMPOUNDS - Iontophoretic patches for the delivery of anti-migraine compounds and methods of using the patches are described.09-01-2011
20110130707Thiadiazole Compounds and Uses Thereof - Thiadiazole compounds, compositions, bioconjugates, and methods for targeting and photoactivation at target sites.06-02-2011
20110130705THERAPY FOR VITILIGO - The present invention relates to a therapy for vitiligo. In particular the present invention provides a pharmaceutical composition comprising an alpha melanocyte stimulating hormone (alpha-MSH) analogue either alone or in combination with one or more corticosteroids, immunosuppressants, anti-inflammatory agents and/or photochemotherapeutic agents for the treatment or prevention of vitiligo.06-02-2011
20110125077OPTICAL STIMULATION THERAPY - Methods of delivering optical stimulation to a target tissue from an optical stimulation device are provided. One method comprises sensing a temperature at the optical stimulation device or proximate to the optical stimulation device, and adjusting the delivery of light to the target tissue based on the sensed temperature. Another method comprises delivering the light to the target tissue with an optical light guide and sensing bioelectric signals with a sense electrode, wherein the optical light guide and the sense electrode each comprise a material that produces substantially no induced current in an electromagnetic field. Another method comprises delivering light from a light source of an optical stimulation device to a window of the optical stimulation device, delivering the light from the window to an optical light guide optically connected to the window, and delivering the light to a target tissue via the optical light guide.05-26-2011
20110087153Transdermal Methods And Systems For The Delivery Of Rizatriptan - Iontophoretic patches for the delivery of rizatriptan and methods of using the patches are described.04-14-2011
20110105998SYSTEMS, METHODS AND COMPOSITIONS FOR OPTICAL STIMULATION OF TARGET CELLS - Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to a light stimulus. The method includes engineering the light-activated ion channel molecule in a cell; and activating the ion channel molecule, in response to light stimulus that is provided to the ion channel molecule and that has properties that do not activate a ChR2 ion channel, to allow ions to pass through the light-activated ion channel molecule. 05-05-2011
20110105997ELECTRICALLY CONTROLLED ION TRANSPORT DEVICE - A device for electrically controlled of ions, comprises a first electrolyte; a first electrode, which is arranged in direct or indirect contact with the first electrolyte, an encapsulation; and an ion conductor, which is arranged to receive and/or deliver ions from/to the first electrolyte. The encapsulation is arranged to effectively enclose the first electrolyte, and the ion conductor is arranged to transport ions from/to an outside of the encapsulation.05-05-2011
20110245756DEVICES FOR MATERIAL DELIVERY, ELECTROPORATION, SONOPORATION, AND/OR MONITORING ELECTROPHYSIOLOGICAL ACTIVITY - The invention relates generally to systems and devices for material delivery, energy delivery, and/or monitoring electrophysiological activity, and method of use thereof. In particular, the present invention provides devices and systems, and methods of use thereof, configured to deliver therapeutic compositions, to provide electroporation and/or sonoporation to increase therapeutic efficiency, and to monitor electrophysiological activity, for example, before and after treatment.10-06-2011
20100262065Liquid submersed light emitting fiber optic handle apparatus system - This is an illuminating Liquid Submersed Light Emitting Fiber Optic Cable(s) which can use a variation of colors that are passed through the fiber optics and used in conjunction with a closed loop vacuum using a liquid or dry abrasion system for treatment to the surface of the skin. The illuminating light emitting color or multi color fiber optic cable(s) provides an on or pulse state of optic light that is submersed in a liquid and vacuum at the end of a replaceable end cap or tip. This is a safe way of transferring submersed fiber optic light with no electricity contact to the skin. The fiber optic light cable(s) are used in conjunction with a type of liquid that is passed or pulled through the handle apparatus. At the end of the handle apparatus is a replaceable end cap or tip.10-14-2010
20100036311ENHANCEMENT OF LIGHT ACTIVATED THERAPY BY IMMUNE AUGMENTATION USING ANTI-CTLA-4 ANTIBODY - The efficacy of light activated therapy treatment is enhanced by stimulating the immune system of the patient substantially above a normal level. Abnormal tissue that is destroyed by the light activated therapy releases factors that stimulate the immune system, leading to systemic reductions in abnormal tissue (i.e., reduction beyond the region treated using light). By further stimulating the immune system using an anti-CTLA-4 antibody, the systemic destruction of abnormal tissue is enhanced.02-11-2010
20090221954IONTOPHORESIS DEVICE - An iontophoresis device (includes a working electrode assembly and a non-working electrode assembly, each having respective organism contact surfaces. A release liner may be peeled off when it is pulled in one direction along the contact surfaces. A base film may be coupled to a front surface of the release liner and may be sized to cover the front regions of the contact surfaces. A paste layer is attached to the front surface of the base film. The paste layer is peeled from the skin by pulling the base film via the release liner. The paste layer retains a part of the stratum corneum or sebum when removed from the skin.09-03-2009
20090048557DEVICE AND METHODS COMBINING VIBRATING MICRO-PROTRUSIONS WITH PHOTOTHERAPY - Method and device for therapeutic or aesthetic treatment of the skin performs a combination of dermabrasion to mechanically modify at least an outer layer of the skin in a first region and phototherapy. The device preferably employs a skin interface element with projections protruding from a substrate which is moved in a vibratory motion by a vibration generating mechanism. This is combined with an illumination system deployed to direct a therapeutically relevant dosage of light towards a surface of the skin against which the skin interface unit is in contact.02-19-2009
20090048555DRUG DELIVERY SYSTEM - A drug delivery system including a chamber, which is configured for enclosing or covering at least a surface of a patient, a source of a drug and a pressure source, which selectively pressurizes the chamber. In addition, the system includes a controller for controlling the transfer of the drug to the chamber wherein the drug is administered to the surface of the patient under pressure.02-19-2009
20090312689Adjustable Current Electrotransport Fentanyl Delivery Device - A transdermal electrotransport fentanyl delivery system having relatively stable fentanyl flux. The system has a controller that controls a current through a donor reservoir wherein the current is generally changed nonlinearly with time with conductance or resistance as a factor to result in a relatively stable fentanyl flux.12-17-2009
20120245506COMBINATION OF AN OXIDANT, A PHOTOSENSITIZER AND A WOUND HEALING AGENT FOR ORAL DISINFECTION AND TREATMENT OF ORAL DISEASE - The present document describes methods of use of photo activated compositions for oral disinfection and/or treatments which comprise at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmacologically acceptable carrier.09-27-2012
20100056984LOW FREQUENCY GENERATION POULTICE - A low frequency generating poultice includes a poultice sheet; a contact fabric that is adhered to a non-medicated surface of the poultice sheet; a release sheet that is attached to a medicated surface of the poultice sheet; a low frequency oscillator; a pair of left and right first through holes; a pair of left and right second through holes that are formed in the poultice sheet, the contact fabric, and the release sheet; and a left clip portion and a right clip portion that have one end fixed to a bottom surface of the low frequency oscillator and the other end passing through the pair of left and right first through holes to be coupled to the poultice sheet through the pair of left and right second through holes and electrically connected to the low frequency oscillator.03-04-2010
20090216176ELECTRONICALLY-CONTROLLED DEVICE FOR RELEASE OF DRUGS, PROTEINS, AND OTHER ORGANIC OR INORGANIC CHEMICALS - A device for drug release including a drug reservoir including a gate, wherein opening of the gate releases a drug stored in the drug reservoir, an electronic command and control (C & C) unit in communication with the gate that produces a gate bias voltage and time profile supplied to the gate for controlling opening of the gate, and a power source for supplying power to the electronic command and control unit.08-27-2009
20090216175Transdermal Administration Device and Method of Controlling the Same - To provide a transdermal administration device capable of increasing the speed at which a drug is transferred into a skin and the amount of the drug to be transferred into the skin. A transdermal administration device is constituted by: an electrode supplied with a voltage of a first conductivity type; an electrolyte solution holding portion holding an electrolyte solution energized by the electrode; and a bipolar membrane that is placed on the front surface side of the electrolyte solution holding portion, and is composed of a first ion exchange membrane that selectively passes an ion of the first conductivity type and a second ion exchange membrane that selectively passes an ion of a second conductivity type.08-27-2009
20100069822System for ex vivo modification of medicament release state - Described embodiments include a system. A described system includes a computer-readable storage medium configured to indicate a stimulus to modify ex vivo a bioavailability of a medicament carried by a final dosage form based upon a selected medicament bioavailability of the final dosage form. The system also includes a holder configured to establish ex vivo of the animal a location of the final dosage form to receive the indicated stimulus from a stimulus source. The system further includes the stimulus source operable to provide the indicated stimulus. The system also includes a stimulation controller operable to regulate an ex vivo exposure of the final dosage form to the indicated stimulus.03-18-2010
20100069821Ex vivo modifiable medicament release-sites final dosage form - Described embodiments include a final dosage form, an article of manufacture, and method. A described final dosage form includes a dosage portion having a medicament, and a site and the medicament in a first association. In the first association, the medicament has a first bioavailability. The first association of the site and the medicament is modifiable ex vivo to a second association an exposure to a stimulus, wherein the medicament has a second bioavailability. The final dosage form includes another dosage portion having another medicament, and another site and the another medicament in another first association. In the another first association, the another medicament has another first bioavailability. The another first association is modifiable ex vivo to another second association of the another site and the another medicament by an exposure to another stimulus, wherein the another medicament has another second bioavailability.03-18-2010
20110082412Device for actively removing a target component from blood or lymph of a vertebrate subject - Devices, systems, and methods are disclosed herein for modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject for treatment of a disease or condition in the vertebrate subject. An implantable device is provided which includes a body defining at least one lumen configured for fluid flow; at least one first reservoir in communication with at least one lumen; one or more energy sources configured to provide energy to elicit one or more signal responses associated with one or more labels that bind to one or more target components in one or more of blood fluid or lymph fluid of the vertebrate subject; one or more sensors configured to detect the one or more signal responses associated with one or more labeled target components; and one or more reactive components in communication with the at least one lumen for release responsive to the one or more sensors.04-07-2011
20110152743IONTOPHORESIS DEVICE ACTIVATED IN USE - An iontophoresis device activated in use, which is capable of supplying a dissolution liquid in an amount that depends on the amount of a drug when it is used, is provided.06-23-2011
20120035529TUMOR VASCULAR MARKER-TARGETED VACCINES - The present invention provides methods of immunizing a subject against a tumor, inhibiting tumor growth, inhibiting tumor recurrence, treating, suppressing the growth of, or decreasing the incidence of a tumor, overcoming tolerance to a tumor vasculature marker (TVM) in a subject comprising the step of administering a vaccine comprising a TVM or a nucleic acid encoding a TVM and related vaccines. The present invention also provides a method of targeting a tumor vasculature in a subject having a tumor comprising the step of contacting said subject with a labeled compound that binds a) a tumor vasculature marker (TVM) or b) a nucleic acid molecule encoding said TVM.02-09-2012
20120035527PHOTOCHEMICAL TISSUE BONDING - The exemplary embodiments of the present invention provides exemplary methods for adhering biological membranes to luminal anatomical structures using photosensitizing agents and electromagnetic energy. The exemplary embodiments of the present invention also provides method for stabilizing luminal anatomical structures. Further, exemplary embodiments of the present invention provide arrangements for coupling to a luminal anatomical structure.02-09-2012
20110098632DEVICE DELIVERING MEDICINES BY TRANSPALPEBRAL ELECTROPHORESIS - The invention concerns a device for ocular application of an active principle (04-28-2011
20110082413ELECTRODE ARRAYS AND METHODS OF MAKING AND USING SAME - Described herein are improved electrode array devices and improved active agent delivery devices. Further described are methods of making and using the improved devices. An improved electrode array device includes a substrate and a plurality of probes disposed on the substrate, wherein the probes are formed from a plurality of aligned carbon nanotubes that are not encapsulated by a structure-providing material. An active agent delivery device includes a substrate having an aperture therein, an active agent delivery member disposed on a first surface of the substrate and having an aperture therein, and an active agent chamber disposed on a second surface of the substrate configured to deliver an active agent through the aperture of the substrate and the aperture of the active agent delivery member.04-07-2011
20110082410Method for Reducing Pain during Photodynamic Therapy - The present invention provides a method for application of photodynamic therapy which results in a reduction of pain experienced by a patient during treatment. An irradiation pattern of short pulses is applied to a treatment site. The same total energy dosage and light intensity parameters for a specific application, as known in the state of the art is used, but the radiation is applied in a series of short pulses. In a preferred embodiment, radiation is applied with about 350 millisecond pulses, and each pulse is separated by about 100 to 500 millisecond intervals. Application of radiation in pulses rather than continuous wave application reduces pain during treatment without sacrificing the therapeutic effect.04-07-2011
20110082409SKIN FORMULATION DISPENSER FOR USE WITH OR AS PART OF A SONIC APPLICATOR - The skin formulation dispenser includes a housing and a reservoir positioned within the housing containing a skin formulation. The dispenser includes an outlet nozzle from which the skin formulation exits and a pump assembly connecting the reservoir to the nozzle. An actuator is provided by which a user can mechanically apply pressure to the pump assembly to move the formulation from the reservoir to the nozzle. The nozzle extends from an end portion of the dispenser into a mating opening in an infuser portion of the applicator in such a manner to insure that the dispenser is authorized for use in the applicator, wherein the nozzle is configured so as to permit movement of the formulation by reasonable force from the reservoir through the nozzle while also preventing overly rapid evaporation of the formulation exiting from the nozzle.04-07-2011
20110152745PDT TREATMENT METHOD FOR CELLULITES AND COSMETIC USE - Methods of treating cellulite by means of percutaneous application of a photosensitizer composition into the area of cellulite buildup followed by light illumination are presented. The photosensitizer can be combined with one or more cellular products including adipose cells and/or collagen that have been previously removed by liposuction. The cosmetic treatment method substantially reduces or removes localized lipodystrophies and/or flaccidity and/or cellulite by localized laser, LED, or other light irradiation of the area of treatment containing a photosensitizer, while minimizing trauma.06-23-2011
20110077582INTRAOCULAR IONTOPHORETIC DEVICE AND ASSOCIATED METHODS - The present invention includes methods and devices for non-invasively delivering an active agent to the eye of a subject. In one aspect, for example, a device for delivering an active agent to an eye of a subject may include an ocular lens-shaped housing configured to contact a surface of the eye, and a reservoir coupled to the housing and configured to deliver an active agent to the eye, wherein the reservoir is located entirely within a 180 degree section of the housing. In another aspect, the reservoir is located entirely within a 150 degree section of the housing.03-31-2011
20110077581TARGETED CELLULAR DELIVERY OF NANOPARTICLES - The various embodiments of the present disclosure relate generally to compositions and methods for the targeted cellular delivery of nanoparticles. More particularly, the various embodiments of the present invention are directed to the cellular delivery of nanoparticles tethered to a ligand by way of a poly(ethylene glycol) linkage, wherein the ligand demonstrates a binding specificity for a cellular target. In an exemplary embodiment, the ligand is tamoxifen and the cellular target is the estrogen receptor, which is upregulated in many breast cancer cells.03-31-2011
20110077579Cochlear implant with localized fluid transport - An apparatus for providing fluid communication with a cochlear lumen, the apparatus includes a delivery-tube configured for insertion into the cochlear lumen. Delivery-tube orifices on the delivery-tube provide fluid communication between a lumen defined by the delivery-tube and the cochlear lumen.03-31-2011
20110077580BIO-MEDICAL UNIT AND APPLICATIONS FOR CANCER TREATMENT - An in vivo cancer treatment system includes a plurality of bio-medical units, a communication control device, and a wireless power source device. A bio-medical unit of the plurality of bio-medical units includes a power harvesting module operable to convert a wireless power source into a supply voltage; a communication module operable to communication data, wherein the communication unit is powered by the supply voltage; and a field generation module operable to generate a type of electromagnetic field, wherein the field generation module is powered by the supply voltage. The communication control device communicates with the plurality of bio-medical units to facilitate treatment of cancer cells within the body. The wireless power source device generates the wireless power source.03-31-2011
20120203161DEUTERATED WATER AND RIBOFLAVIN SOLUTION FOR EXTENDING SINGLET OXYGEN LIFETIMES IN TREATMENT OF OCULAR TISSUE AND METHOD OF USE - A solution of deuterated water containing a riboflavin-based photosensitizer is provided in order to extend life-times of UVA/Rf photo-generated intra-stromal singlet oxygen, in combination with UVA delivery profiles of pulsing, fractionation, and optionally auxiliary stromal/Rf hyper-oxygenation in order to accelerate protein cross-linking density rates in ocular tissue. A 100% deuterated water solution with 0.1% riboflavin in solution increases singlet oxygen lifetimes by at least an order of magnitude without inducing endothelial cell apoptosis, thereby also permitting use of some combination of lower percentages of deuterated water, lower concentrations of riboflavin or lower dosages of UVA on intact (un-debrided) epithelium for equivalent cross-link densities compared to current acceptable corneal cross-linking procedures. Lower concentrations of deuterated water with regular water, for example, yields shorter singlet oxygen lifetimes in approximately linear proportion to concentration, which are considered acceptable in therapies known or being developed in the art of corneal cross-linking.08-09-2012
20120302940Popcorn Shape Gold Nanoparticle For Targeted Diagnosis, Photothermal Treatment and In-Situ Monitoring Therapy Response for Cancer and Multiple Drug Resistance Bacteria - The present invention provides multifunctional popcorn-shaped gold nanomaterial for sensing, treatment and for a unique way of monitoring treatment effectiveness during therapy process of different human cancer cells and pathogenic bacteria. It consists of the following steps 1) Synthesis of popcorn-shaped gold nanoparticles of different sizes. 2) Design of multifunctional popcorn-shaped gold nanoparticle for targeted sensing, therapy and monitoring therapy effectiveness for different human cancer cells (liver, breast, skin and prostate) and drug resistance bacteria. 3) Design of portable SERS sensor for cancer detection, treatment and for monitoring treatment effectiveness using the same instrument. and 4) Application of our approach to detect and kill MDRB from food sample.11-29-2012
20120302939Means and method to painlessly puncture skin - A means and a method is disclosed to diminish or eliminate the pain associated with a sharp object penetrating the skin, during such procedures as an injection, biopsy, or deriving a blood sample. To this end, repeated tapping, pressing, or rubbing is performed over the skin at or near the site of penetration of the sharp object in conjunction with applying electricity on the skin. The invention discloses a method of using a skin-puncturing means, with enhanced features, to provide local anesthesia at the site of penetration of a sharp object.11-29-2012
20120277660COMPOSITION AND METHOD FOR TREATMENT OF MRSA - The present invention provides a photosensitizing composition for treatment of MRSA comprising a photosensitizer and chlorhexidine and a pharmaceutically acceptable carrier. The present invention also provides a method for reducing disease causing microbes comprising: applying the composition comprising a photosensitizer, chlorhexidine at a concentration of more than about 0.01% and less than about 2% v/v, and a pharmaceutically acceptable carrier to a treatment site; and applying light to the treatment site at a wavelength absorbed by the photosensitizer so as to reduce the microbes at the treatment site.11-01-2012
20110257585Medical Apparatus - There is herein described medical apparatus. More particularly, there is herein described medical apparatus capable of adapting and/or conforming to a non-planar surface on a patient's body.10-20-2011
20110213293LIGANDS TO RADIATION-INDUCED MOLECULES - A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.09-01-2011
20110178456ASSISTING TRANSDERMAL DRUG DELIVERY BY MEANS OF TISSUE FREEZING, VACUUM PRESSURE AND PHOTOHEATING PROCEDURES - This disclosure relates generally to methods for increasing the permeability of tissue. More particularly, it relates to increasing the permeability of a skin tissue or other epidermal tissue to promote delivery of active substances locally and systemically, and to control the delivery of active substances topically.07-21-2011
20110152746METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL - The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.06-23-2011
20110160641BATTERY PACK AND ELECTRONIC DEVICE ASSEMBLY INCLUDING BATTERY PACK - This invention relates to an improvement in battery packs. The invention intends to provide a highly flexible battery pack and an electronic device assembly using the same. The battery pack of the invention includes an elastic sheet and at least one coin battery embedded in the elastic sheet. In a preferable embodiment of the invention, the electronic device assembly includes a laminate of the battery pack and a flexible electronic device. The electronic device is driven by power supplied through positive and negative terminals of the battery pack. In another preferable embodiment of the invention, the electronic device assembly includes the battery pack and a device embedded in the elastic sheet of the battery pack, and the device is driven by power supplied by the at least one coin battery.06-30-2011
20110152744MODULATOR OF VASCULAR PERMEABILITY USING PULSED LASER AND METHOD FOR MODULATING VASCULAR PERMEABILITY USING THE SAME - Disclosed herein is a modulator of vascular permeability using pulsed laser and a method for modulating vascular permeability using the same. More specifically, because the pulsed laser effectively induces vascular permeabilization, effectively delivers intravascular materials into tissues and minimizes insult to the tissues by the induced vascular permeabilization, and locally targets a subcutaneous tissue for noninvasive modulation due to its nonlinearity, it may be usefully used for modulation of permeability.06-23-2011
20120203162METHOD FOR TREATING NEOVASCULARIZATION - The present invention describes an improved photodynamic treatment to treat subfoveal choroidal neovascularization (CNV).08-09-2012
20100004581METHODS AND DEVICES FOR MINIMALLY-INVASIVE EXTRAOCULAR DELIVERY OF RADIATION TO THE POSTERIOR PORTION OF THE EYE - Methods and devices for minimally-invasive delivery of radiation to the posterior portion of the eye including a cannula comprising a distal portion connected to a proximal portion and a means for advancing a radionuclide brachytherapy source (RBS) toward the tip of the distal portion; a method of introducing radiation to the human eye comprising inserting a cannula between the Tenon's capsule and the sclera of the human eye and emitting the radiation from the cannula on an outer surface of said sclera.01-07-2010
20090281475IONTOPHORETIC ELECTROTRANSPORT DEVICE - An electrotransport device for transdermal drug delivery has a number of electrodes and driving circuitry for supplying driving signals to the number of electrodes. The electrodes are connected to the driving circuitry in rows and columns. The driving circuitry has row driving circuitry for supplying a row signal to a row of electrodes, and column driving circuitry for supplying a column signal to a column of electrodes. A predetermined electrode is individually addressable by supplying a row signal to a corresponding row of electrodes and a column signal to a corresponding column of electrodes.11-12-2009
20090062723CURRENT PRODUCING SURFACE FOR TREATING BIOLOGIC TISSUE - In an embodiment, an article includes a primary surface, and a pattern of spaced dissimilar materials, on the primary surface. The pattern is to spontaneously produce electrical surface currents when brought into contact with an electrically conducting solution.03-05-2009
20110257582MEDICATED SHEET - An object of the present invention is to safely discard the electrode plate having pin holder-shaped projections of a medicated sheet by incineration. An electrode plate with pin holder-shaped projections is made from a conductive resin in which carbon black serving as a conductive substance is mixed to a thermoplastic resin, so that the electrode plate including the pin holder-shaped projections can be safely discarded by incineration.10-20-2011
20110257587Iontophoretic Delivery of Curcumin and Curcumin Analogs for the Treatment of Alzheimers Disease - A device for iontophoretically delivering a charged curcuminoid across the skin of an Alzheimer's Disease patient.10-20-2011
20090118663SYSTEMS AND METHODS FOR ENHANCED OCCLUSION REMOVAL DURING OPHTHALMIC SURGERY - A method and apparatus for performing a surgical procedure is provided. The surgical procedure may be a phacoemulsification procedure but other procedures may employ the techniques disclosed. The design includes sensing, within the surgical site, for a material change in fluid flow relative to a predetermined threshold. Upon sensing the fluid flow materially differs from the predetermined threshold, the design temporarily increases aspiration vacuum pressure to the surgical site above a predetermined upper threshold toward a maximum vacuum level. The design applies electrically generated disruptive energy, including but not limited to laser and/or relatively low power ultrasonic energy, to the surgical site from a first point in time measured from when aspiration vacuum pressure is above the predetermined upper threshold to a second point in time where pressure falls below a predetermined lower threshold.05-07-2009
20120277659SENSOR-LOTION SYSTEM FOR USE WITH BODY TREATMENT DEVICES - Controls improve skin and/or eye safety for use of a light based photocosmetic device. The sensors having high spatial resolution and the low probability of sensor failure and improve skin and/or eye safety by differentiating safe and unsafe firing conditions. The system and/or the device is able to identify a topical present on the skin due to characteristics indicative of that topical that are sensed by the system. The topical can be identified by, for example, impedance level, marker(s), and/or multiple characteristics in a multi-phase system. The sensor(s) can improve safety by checking the presence of contact and the uniformity of contact with the identified topical throughout the treatment cycle.11-01-2012
20080214985Active transdermal medicament patch - An active transdermal medicament patch includes a planar substrate with a therapeutic face releasably retainable against the skin of a patient. A return electrode and a medicament matrix susceptible to permeation by medicament are secured at separated locations on the therapeutic face. Each electrically conductively engages the skin, when the substrate is retained thereon. A power source carried on the substrate is electrically coupled between the medicament matrix and a programmed microprocessor also carried on the substrate. A substantially invariant voltage presented at an output contact of the microprocessor is applied during a predetermined therapy period across the skin between the medicament matrix and the return electrode, inducing transcutaneous migration of medicament into the skin at a substantially constant rate. A light-emitting diode carried on the substrate and coupled to the microprocessor communicates that the patch is operating.09-04-2008
20110054383INSTRUMENT FOR CONTINUOUS DISCHARGE OF ANESTHETIC DRUG - The present invention is directed towards instruments and methods for discharging an anesthetic drug on a continuous basis for use as a nerve block. In accordance with the present invention, a catheter assembly is provided that comprises an electrically conductive wire, a protective sheath and an inflatable balloon. The inflatable balloon is at the distal end of the catheter capable of being inflated and deflated. A balloon channel terminates within the inflatable balloon at the distal end of the catheter and extends proximally along the length of the catheter to the proximal end of the catheter. The balloon channel has a balloon channel opening at a distal end of the balloon channel within the inflatable balloon, capable of releasing an injected substance into the inflatable balloon. The balloon channel further has a balloon channel injection opening at a proximal end of the balloon channel, capable of receiving an injected substance.03-03-2011
20110021973FORMULATIONS FOR COSMETIC AND WOUND CARE TREATMENTS WITH PHOTOSENSITIZERS AS FLUORESCENT MARKERS - Photoactive materials, such as photosensitizers, are used as fluorescent markers for in vivo detection of the distribution of the injected filler material during cosmetic treatments. In one preferred embodiment, liposomal formulated temoporfin is used, as the photoactive component, in very small concentrations along with fillers for cosmetic and wound healing applications. Fillers, which can be used in the invention, include collagen, hyaluronic acids and other synthetic or natural products which are generally used in wound healing, scar reduction and other such medical applications. In a preferred embodiment, the formulated photosensitizer is coupled to the filler so that tracking is possible over longer periods of time A liposomal formulated photosensitizer is injected with the fillers into the treatment area, and is irradiated with laser light shortly after injection. The emitted fluorescence is measured by a special non-invasive device. Thereby it is possible to monitor the injection site and the distribution of the injected solution around the injection site. When irradiated with laser or other light source, the fluorescence of the photosensitizer is detected using a fluorescence detector, which permits tracking the filler at injection site and in the injection volume.01-27-2011
20110021971SELECTIVE TREATMENTS FOR CHRONIC RHINOSINUSITIS - Method for treating chronic rhinosinusitis in a human patient. In the method a photosensitizing agent such as indocyanine green can be applied to color a nasal or sinal treatment site harboring infectious microorganisms. The photosensitizing agent can have an energy absorption peak in a near infrared wavelength region of the electromagnetic spectrum. The method can also include applying light energy from a laser source at a near infrared red wavelength or wavelengths to the colored treatment site, for a duration sufficient to control the microorganisms. Apparatus for performing the method is also disclosed.01-27-2011
20110264028Active transdermal drug delivery system and the method thereof - The present invention relates to an active transdermal drug delivery system performing transdermal drug delivery comprising of a patch capable of being attachable to the skin of the subject; at least one electrical energy power input; a plurality of converters/energy transducers configured for converting the electrical energy to different forms of energy; and a controller including a programmable microprocessor configured for providing the intensity, sequence, nature, and timing information for the different energies supplied and thereby providing activating signals to the said converters for the transdermal drug delivery by the said patch, and a method for performing transdermal drug delivery using said electronic patch.10-27-2011
20110257586CALCIUMPHOSPHATE-BASED NANOPARTICLES AS CARRIER-SYSTEMS FOR PHOTODYNAMIC THERAPY - The present invention provides pharmaceutical photosensitizer-loaded nanoparticle formulations and their methods of preparation for photodynamic therapy, comprising a hydrophobic or hydrophilic photosensitizer, nanoparticulate calcium phosphate and in certain cases auxiliary reagents such as stabilizers. The calcium phosphate-based nanoparticle formulations of the present invention provide excellent storage stability and therapeutically effective amounts of photosensitizer for intravenous or topical administration. In a preferred embodiment, tetrapyrrole derivatives such as porphyrins, chlorins and bacteriochlorins, are the preferred hydrophobic photosensitizers to be formulated in calcium phosphate nanoparticle formulations for photodynamic tumor therapy. Additionally, 5,10,15,20-tetrakis(4-phosphonooxyphenyl)porphine (pTPPP) is a preferred hydrophilic photosensitizer for photodynamic tumor therapy. In another preferred embodiment, hydrophilic cationic and anionic photosensitizers, especially those of the phenazinium, phenothiazinium and xanthenes series have been found to inactive pathogen bacteria and are the preferred photosensitizers to be formulated in calcium phosphate nanoparticle formulations for antibacterial photodynamic therapy. In another embodiment, photosensitizing nanoparticle formulations are useful to locate cells, tissues or bacteria by using fluorescence imaging methods.10-20-2011
20110257584METHODS AND DEVICES FOR INJECTION OF A SUBSTANCE INTO TISSUE - Substances are injected (e.g. laser injected) into skin tissue in order to change optical and/or mechanical properties of the tissue. Methods include ablating one or more micro-holes into tissue, pushing a substance into the one or more micro-holes with energy from the creation of the mirco-holes, with acoustic energy, and/or with laser energy. A container component is filled with the substance to be injected into the skin tissue.10-20-2011
20110087154Transdermal Systems for the Delivery of Therapeutic Agents Including Granisetron Using Iontophoresis - A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.04-14-2011
20100292630Meibomian Gland Intraductal Diagnostic and Treatment Methods - A method is provided for treating a meibomian gland of an eyelid of a patient. In a particular embodiment, an obstruction in a meibomian gland and the orifice thereof can be alleviated; in another, a substance can be injected thereinto; in yet another, the gland can be aspirated. The method includes the step of inserting an elongated probe into a meibomian gland via an orifice thereinto. In some embodiments the probe can have a longitudinal lumen therethrough, with at least one distal hole through the probe wall in fluid communication with the lumen. The lumen can be used in concert with a source of suction for removing debris from the meibomian gland, and/or with a source of a fluid and pumping means, for injecting a substance into the meibomian gland.11-18-2010
20110118655GALVANIC SKIN TREATMENT DEVICE - A galvanic device for treatment of skin is provided. The device comprises a substrate comprising a plurality of discrete galvanic couples, each galvanic couple comprising a first conductive electrode that is an anode in electronic communication with a second conductive electrode that is a cathode.05-19-2011
20110118653Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject - A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes an enclosure including one or more sensors, a controller, and one or more applicators configured to surround one or more joints of articulating bone of a mammalian subject, wherein the one or more sensors are configured to detect one or more physiological conditions of the one or more joints of the mammalian subject, and the controller, configured to communicate with the one or more sensors, is configured to activate the one or more applicators, and wherein the one or more applicators are configured to inject one or more medicaments to one or more joint tissues of the mammalian subject.05-19-2011
20110028886Catheter - An apparatus for treatment of tissue within a body requiring thermotherapy includes a catheter to be inserted into a bodily conduit, an energy-emitting source disposed within the catheter, a compression balloon surrounding the energy-emitting source where the compression balloon has an inflated diameter that is greater than that of the bodily conduit in a relaxed state and an outside surface of the balloon is coated with one of gene modifiers and drug or medication, and means for activating the energy-emitting source to radiate energy to heat the drug-coated compression balloon and tissue to be treated whereby the heated drug-coated compression balloon effectively delivers the one of the gene modifiers and drug or medication to a target area of the diseased tissue. In addition, methods for using the above apparatus to treat diseased tissue are disclosed.02-03-2011
20110125080ULTRASOUND MEDIATED DRUG DELIVERY - Described is a method for the delivery of a therapeutic agent to a mammal, particularly a human person, comprising (i) the administration of ultrasound particles that undergo a physical change when subjected to ultrasound; (ii) the administration of the therapeutic agent in an ultrasound dosage form allowing release of the therapeutic agent to be affected by the application of ultrasound, (iii) the application of ultrasound so as to affect a physical change in at least some of the ultrasound particles, and (iv) the application of ultrasound so as to stimulate release of the therapeutic agent. According to the invention the ultrasound particles are subjected to detection of their acoustic responses via echoes and/or emissions. The information thus obtained is processed and the processed information is used to adapt or adjust the ultrasound-mediated delivery of the therapeutic agent. This can be carried out using a single set of particles (that serve both as ultrasound imaging tracers and as drug delivery vehicles) or by applying separate sets of particles.05-26-2011
20110125078OPTICAL STIMULATION THERAPY - A method for delivering optical stimulation comprises transfecting a target tissue with a light-sensitive channel protein sensitive to light in a wavelength range, delivering light in the wavelength range to the target tissue via an optical stimulation device, substantially simultaneously with delivering light to the target tissue, sensing bioelectric signals, determining a patient therapeutic state based on the bioelectric signals, and adjusting the delivery of the light to the target tissue based on the sensed patient therapeutic state.05-26-2011
20110125075METHOD FOR CONTROL OF ELECTROPORATION APPARATUS - A method for controlling an electroporation apparatus for use in an animal such as human and a non-human animal, the method comprising a step of applying a voltage to an electrode of the electroporation apparatus placed in/on a biological sample of the animal in the presence of a nucleic acid construct capable of inhibiting the expression of a gene in the animal. In this manner, a nucleic acid construct can be introduced into a cell of a living body with good efficiency.05-26-2011
20110137230Method and Apparatus for Medical Treatment Utilizing Long Duration Electromagnetic Radiation - A method and apparatus are provided for performing a medical procedure on a patient, for example a dermatological procedure, by use of electromagnetic radiation (EMR) having a relatively low peak power, and in particular a peak power low enough so as not to result in a phase change in the heater or chromophore absorbing radiation which would result in a significant reduction in its absorption, and of relatively long duration which is generally greater than, sometimes significantly greater than, the thermal relaxation time of the irradiated target.06-09-2011
20100305495METHOD AND APPARATUS FOR DERMAL DELIVERY OF A SUBSTANCE - The present invention is directed to a method and apparatus for delivering substances, e.g., therapeutic substances, into openings on or near a skin surface, such as hair follicles, pores and/or into sebaceous glands. This can be achieved by using an apparatus to direct a substance into the openings under pressure via one or more nozzles or slits. A portion of the sebum present in the hair follicle is optionally heated and/or removed, e.g. using low-pressure conduit located on the lower surface of the apparatus, before introducing the therapeutic substance.12-02-2010
20100305494METHOD FOR PHOTODYNAMIC THERAPY AND APPARATUS THEREFOR - Photodynamic therapy is used in the treatment of orthopaedic infections. Particularly, it is used in the treatment of infections related to orthopaedic conditions and surgery and includes treatment of sites of deterioration or trauma, such as prior to and after prosthetic fixation such as joint replacement or treatment of trauma sites such as pinning of bone fractures. An orthopaedic disinfection apparatus includes a photosensitiser and a light delivery system capable of producing and delivering light at a wavelength which is capable of being absorbed by the photosensitiser. Methods of treatment of orthopaedic infections are also disclosed.12-02-2010
20110082411PATCH AND PATCH ASSEMBLY FOR IONTOPHORETIC TRANSDERMAL DELIVERY OF ACTIVE AGENTS FOR THERAPEUTIC AND MEDICINAL PURPOSES - Embodiments of the invention provide patch assemblies for iontophoretic transdermal delivery of therapeutic agents. An embodiment provides a patch assembly comprising a conformable patch for delivery of the agent and having a tissue contacting side including an adhesive. The housing has a bottom surface for engaging a non-tissue contacting side of the patch, a current source such as a battery and a controller for controlling the delivery of the agent. The housing has sufficient flexibility such that when it is engaged with the patch to form the patch assembly and the patch is adhered to a target site on the patient's skin, the assembly has sufficient flexibility to deform with movement of the patient's skin to remain sufficiently adhered to the skin over an extended period of time to transdermally deliver a desired dose of the agent. Embodiments of the assembly may used to deliver a variety of therapeutic agents.04-07-2011
20100324470Dosage Control Electrode for Iontophoresis Device - An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species has a base layer of including a linking conductive base material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the linking conductive base material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, connected by a narrow exposed linking area of the base layer material remaining exposed therebetween. During operation of an associated iontophoresis device, the sacrificial material will be sequentially consumed; the first upper layer will be fully consumed followed by the linking conductive base material of the exposed linking area of the base layer which severs the base layer thereby breaking circuit continuity disabling activity in the device. A visual indicator may be provided allowing a wearer to monitor the state of reaction of the linking area.12-23-2010
20090171263System, devices, and methods including actively-controllable superoxide water generating systems - Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.07-02-2009
20090171264Medical Devices Based On Poly(Vinyl Alcohol) - Provided are orthopedic implants and scaffolds comprising poly(vinyl alcohol) which has a degree of hydrolysis of at least 90% and a weight average molecular weight of at least 50,000. Also provided are methods for making same.07-02-2009
20090171262Method and Mixture for In Vivo Photochemical Cross-Linking of Collagen - A method and a composition for photochemical cross linking of collagen by photoactive agent in-vivo are presented. The method includes a non-toxic photoactive formulation of the composition with collagen, which is administered to treatment area locally; followed by irradiation with suitable wavelength. In one of the embodiment liposomal formulated mTHPC is added to the collagen and is irradiated with a 652 nm laser, resulting in producing efficient collagen scaffolds with strengthen and stabilized microstructure, thus improving the physiochemical properties of the collagen scaffold. It improves the thermo stability, mechanical property and swelling ratio of newly formed scaffold. Photochemical cross-linked collagens shows antimicrobial effect, when irradiated with suitable wavelength it disinfects the treatment site and curbs microbial growth.07-02-2009
20110166501Method and apparatus for the delivery of polynucleotide vaccines to mammalian skin - An object of the invention is to provide a method and apparatus for the delivery of polynucleotide vaccines into mammalian skin cells to increase T cell response and to reduce pain and discomfort due to long electric waveform application and due to muscle contractions. The method for the delivery of polynucleotide vaccines into mammalian skin cells includes the steps of: (a.) administering a polynucleotide vaccine into the skin at an administration site, (b.) applying a needle electrode to the skin in the vicinity to the administration site, and (c.) applying a sequence of at least three single, operator-controlled, independently programmed, narrow interval electrical waveforms, which have pulse intervals that are less than 100 milliseconds, to deliver the polynucleotide vaccine into the skin cells by electroporation. The sequence of at least three waveforms has one, two, or three of the following characteristics (1) at least two of the at least three waveforms differ from each other in waveform amplitude, (2) at least two of the at least three waveforms differ from each other in waveform width, and (3) a first waveform interval for a first set of two of the at least three waveforms is different from a second waveform interval for a second set of two of the at least three waveforms.07-07-2011
20100121252NON-INVASIVE VASCULAR TREATMENT SYSTEMS, DEVICES, AND METHODS OF USING THE SAME - An energy treatment system to treat a patient includes an energy delivery device having a plurality of energy emitters used in combination with an energy activatable drug. A mask can be used to define a treatment area. Energy from the energy emitters passes through an optical window of the mask to activate a cosmetically and/or therapeutically effective amount of the activatable drug at the target site to bring about a desired change of tissue, for example, to reduce visibility of one or more blood vessels, while energy from the energy emitters directed outside of the target site is blocked by the mask.05-13-2010
20110137229TREATING BACTERIA WITH ELECTRIC FIELDS - Cells that are in the process division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time at particular frequencies with particular filed strengths. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like bacteria, but does not harm normal cells that are not dividing. Since the vulnerability of the dividing cells is strongly related to the alignment between the long axis of the dividing cells and the lines of force of the electric field, improved results can be obtained when the field is sequentially imposed in different directions.06-09-2011
20100130911PLASMA SOURCE - The invention relates to a plasma source (05-27-2010
20100121254Method and apparatus for skin treatment - Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the use of multiple light sources for treating skin with or without the use of a topical compositions or photomodulation enhancing agents. Dual light emitting diodes may, for example, be used at relatively low power (less than about 10 J/cm2) to photomodulate skin or living tissue to reduce wrinkles, fine lines, acne, acne bacteria, and other skin disorders.05-13-2010
20120041357METHOD OF CONTROLLED DRUG RELEASE FROM A LIPOSOME CARRIER - Disclosed are methods and compositions for the controlled release of a drug or agent from a liposome using light or radiation. Also disclosed are compositions comprising liposomes having a lipid layer, wherein the liposomes contain an agent, an enzyme capable of releasing the agent from the liposome, and an enzyme activator sequestered by a molecular cage. In another aspect, methods of delivering an agent to a target in a subject are disclosed.02-16-2012
20100191172ILLUMINATOR FOR PHOTODYNAMIC THERAPY - An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. Adjustment of the ballast voltage controls the output power of the tubes. The tubes are supported by a sheet-metal or plastic housing and are covered by a polycarbonate shield which directs cooling airflow within the unit and prevents glass-patient contact in the vent of tube breakage. An aluminum reflector located behind the tubes increases both the output irradiance and the uniformity of the output distribution. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity. A light sensor monitors output from the U-shaped tubes to provide a signal for adjusting the output from the tubes.07-29-2010
20110190688Permeant Delivery System and Methods for Use Thereof - Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.08-04-2011
20110264026Azo Derivatives and Uses Thereof in Phototherapy - The invention relates generally to optical agents, including Type 1 phototherapeutic agents, for biomedical applications, such as phototherapy. Provided are fused ring azo and diaza compounds comprising a plurality of fused rings including a first ring having an intra-ring azo or intra-ring diaza group capable of activation upon exposure to electromagnetic radiation in visible and/or infrared regions of the electromagnetic spectrum. Optical agents of the invention enable a versatile phototherapy platform for treatment of a range of pathological conditions, including the treatment of cancers, stenosis and inflammation. The invention further provides preparations and formulations comprising the fused ring azo and diaza compounds and methods of making and using the fused ring azo and diaza compounds as optical agents in in vivo or ex vivo biomedical procedures.10-27-2011
20110137228Use of Green Porphyrins to Treat Neovasculature in the Eye - Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions.06-09-2011
20110152747MEDICAL DEVICE WITH ELECTROACTIVE POLYMER POWERED BY PHOTOVOLTAIC CELL - Medical devices comprising an electroactive polymer powered by a photovoltaic cell. In one embodiment, the medical device has an electroactive component comprising an electroactive polymer. The medical device further comprises a photovoltaic cell as a source of electrical power for electrically stimulating the electroactive polymer. The medical device further comprises a first electrode and a second electrode, both of which are electrically connected to the photovoltaic cell. The electroactive component covers over at least a portion of the first electrode. Also disclosed is a method of treating a patient using a medical device having an electroactive polymer powered by a photovoltaic cell.06-23-2011
20100280432BIOSYNCHRONOUS TRANSDERMAL DRUG DELIVERY - Systems and methods for treating diseases, addictions and disorders in humans and animals involving synchronizing and tailoring the administration of drug compounds with the body's natural circadian rhythms, in order to counteract symptoms when they are likely to be at their worst. Automated and pre programmable transdermal drug administration system are used. This system can also utilize a pump or pressurized reservoir, and/or a system for removing depleted carrier solution, or other modulated dispensing actuator, in conjunction with micro-fabricated structures commonly referred to as Micro-needles, or heat, or iontophoresis, sonophoresis, or a wide range of chemical permeation enhancers.11-04-2010
20110201994METHODS TO REGULATE POLARIZATION OF EXCITABLE CELLS - Minimally invasive delivery with intercellular and/or intracellular localization of nano- and micro-particle solar cells within and among excitable biological cells to controllably regulate membrane polarization of such cells. The cells include retinal and other sensory cells, muscle cells, and nerve cells.08-18-2011
20110201993DETECTING APPARATUS AND MEDICAL CONTROL METHOD - A detecting apparatus includes: a first detecting unit that acquires drug accumulation information concerning a drug which has a been dosed to a subject and has accumulated in a lesion region of the subject; a calculating unit that calculates, on the basis of the drug accumulation information, a change with time of the drug accumulation information in the lesion region as change-with-time information; a threshold setting unit for setting, on the basis of the change-with-time information, a threshold for detecting the drug accumulated in the lesion region; and a second detecting unit for detecting, on the basis of the threshold, the drug accumulated in the lesion region.08-18-2011
20100030128IONTOPHORESIS DEVICE - The transport efficiency of a drug using an iontophoresis device is increased using a negative pressure device.02-04-2010
20100022941WOUND TREATMENT SYSTEM AND METHOD OF USE - A wound treatment system includes a vessel that is sized to receive a human limb. The vessel includes a chamber with an opening leading into the chamber A removable liner lines the chamber of the vessel and forms a treatment zone. A humidifier in fluid communication with the treatment zone humidifies a solution of water and antibacterial agent. An oxygen source is in fluid communication with the treatment zone. A speaker is coupled to the vessel and emits low frequency sound waves to the chamber. a first array of light emitting diodes that emits ultraviolet light is coupled to the vessel near the opening of the treatment chamber. A second array of light emitting diodes that emits pulsed light into the chamber is coupled to the chamber. The system also includes a control panel.01-28-2010
20100022942DEVICE FOR PERCUTANEOUS ABSORPTION PREPARATION - The invention provides a device for a percutaneous absorption preparation, provided with a solution storage container which can exhibit good solution migration independently of the level of force. The device for a percutaneous absorption preparation comprises an electrode film comprising a base member (01-28-2010
20110218482OXIDATITIVE PHOTOACTIVATED SKIN REJEUVENATION COMPOSITION COMPRISING HYALURONIC ACID, GLUCOSAMINE, OR ALLANTOIN - There is provided a skin rejuvenation composition which comprises at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmaceutically acceptable carrier.09-08-2011
20100016781Iontophoresis device selecting drug to be administered on the basis of information form sensor - An iontophoresis device including an electric power source. A first electrode assembly is electrically coupled to the electric power source to transdermally administer an ionic drug to an organism via iontophoresis while a second electrode assembly is electrically coupled to the electric power source as a counter electrode to the first electrode assembly. A sensor may be positioned proximate an internal or external portion of the organism and operable to determine information used to select and deliver the ionic drug to the organism.01-21-2010
20110021974RETINITIS PIGMENTOSA TREATMENT AND PROPHALAXIS - The invention relates to a method of instilling insulin ophthalmic drops in the conjunctival sac for treating retinitis pigmentosa due to any etiological factors both genetic and non genetic. The retinitis pigmentosa is treated with Insulin and/or IGF-I with or without known anti-retinitis pigmentosa therapeutic, pharmaceutical, biochemical, and biological agents or compounds. The invention furthermore uses this method as prophylactic on patients where the patients are predisposed to develop retinitis pigmentosa. The invention additionally treats other oculopathies associated with and/or contributing to retinitis pigmentosa.01-27-2011
20080319372TREATING BACTERIA WITH ELECTRIC FIELDS - Cells that are in the process division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like bacteria, but does not harm normal cells that are not dividing. Since the vulnerability of the dividing cells is strongly related to the alignment between the long axis of the dividing cells and the lines of force of the electric field, improved results can be obtained when the field is sequentially imposed in different directions.12-25-2008
20100100031IONTOPHORESIS DEVICE - The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.04-22-2010
20080208104Laser Microporator - The laser micro-porator (08-28-2008
20100010417Radiation sensitizer or anti-cancer chemotherapy sensitizer - The present invention provides a novel radiosensitizer or anti-cancer chemotherapy sensitizer. In particular, the invention provides a radiosensitizer or anti-cancer chemotherapy sensitizer that can relieve the irritation of an affected area caused by hydrogen peroxide, is safe when injected into a human body, and can delay or reduce the degradation of hydrogen peroxide and thereby can efficiently exert a radiation sensitizing effect and an anti-cancer chemotherapy sensitizing effect. The radiosensitizer or anti-cancer chemotherapy sensitizer comprises a combination of (a) hydrogen peroxide and (b) hyaluronic acid or salt thereof.01-14-2010
20110118654Eye Therapy - Embodiments apply a cross-linking agent to a region of corneal tissue. The cross-linking agent improves the ability of the corneal tissue to resist undesired structural changes. For example, the cross-linking agent may be Riboflavin or Rose Bengal, and the initiating element may be photoactivating light, such as ultraviolet (UV) light. In these embodiments, the photoactivating light initiates cross-linking activity by irradiating the applied cross-linking agent to release reactive oxygen radicals in the corneal tissue. The cross-linking agent acts as a sensitizer to convert O05-19-2011
20080262415ENHANCED WOUND HEALING - A method comprising non-systemic localized administration of a pharmaceutically acceptable formulation and effective concentration of at least one neurostimulatory and/or neuroprotective macrolide or other agent for a duration sufficient to enhance viability, confer protection, reduce scar formation, reduce degeneration and/or enhance regeneration of neural cells, and/or stimulate sensation. The method may be used to reduce scarring in a burn or a surgically created wound or a due to infection with an agent that results in scarring.10-23-2008
20110021972Composition and Device Structure For Iontophoresis - Device structure 01-27-2011
20110306922LIGHT-EMITTING DEVICES FOR PHOTOTHERAPY - Some embodiments provide a compound represented by Formula 1. Other embodiments provide an organic light-emitting diode device, such as a light-emitting device for phototherapy, comprising a compound of Formula 1. Other embodiments provide an organic light-emitting device optionally comprising a wavelength convertor. Methods related to the treatment of diseases using phototherapy area also described.12-15-2011
20110306918Phototherapy patch - A phototherapy patch is disclosed, which includes: an adhesive layer, having a first surface and an opposite second surface; a pharmaceutical drug layer, disposed on the first surface of the adhesive layer; and a spontaneous emission layer, disposed over the pharmaceutical drug layer and capable of emitting therapeutic light by light illumination or a chemical reaction. Accordingly, the phototherapy patch according to the present invention has no power supply disposed therein, and thereby is suitable to be manufactured as a particularly thin and thus inconspicuous device.12-15-2011
20110306921THERAPEUTIC DEVICE AND METHODS OF USING AND MAKING SAME FOR MULTIMODAL STIMULATION OF LIVING TISSUE - Therapeutic devices for stimulation of living tissue are provided. Multimodal stimulation may be mechanical, electrical, chemical, sensory and combinations thereof. The devices have a matrix sufficiently elastic so that when attached to the tissue, the matrix is capable of applying force upon the tissue and compliantly responding to force resultant from motion of the tissue. The devices also have an electrically conductive region contained within the matrix, so that, selectable locations of the device are capable of being in electrical communication with a power source and with the tissue. Methods of stimulating tissue as well as methods of making the devices are also provided.12-15-2011
20110306920MEDICAL DEVICE AND METHOD FOR INCREASING ANTI-OXIDATION CAPABILITY - A medical device and a method of increasing an anti-oxidation capability of an animal cell are provided. The method of increasing the anti-oxidation capability of the animal cell comprises steps of providing the animal cell, and disposing a far-infrared (FIR) emitter in a certain distance from the animal cell. Particularly, the FIR emitter includes a mineral oxide.12-15-2011
20110306919Selective Photostimulation to Induce Cell Proliferation - The invention is based, at least in part, on the discovery that if a tissue is irradiated with a sublethal dose of radiation, e.g., from a laser, that pigmented cells in the tissue are selectively stimulated to proliferate and to produce higher levels of certain mitogenic factors and growth factors such as platelet derived growth factor (PDGF). In particular, the various parameters of a pulsed laser beam, such as power, pulse duration, total radiation energy (‘fluence’), wavelength, and if multiple pulses are used, the pulse rate and total number of pulses, are carefully selected and controlled to minimize killing the irradiated pigmented cells.12-15-2011
20110306917Activation of the alternative cellular energy (ACE) pathway in the therapy of diseases - Alternative cellular energy pigments (ACE-pigments) provide a source of cellular energy other than that provided through the oxidative metabolism of foods, or in the case of plants and certain bacteria, through the process of photosynthesis. In some patients, ACE pigments exist in a form that can be further energized or activated using ultraviolet (UV) light, especially if the reaction is initially triggered by the presence of suitable dyes, such as neutral red. An alternative method has been described to activate the ACE pathway in humans and animals deprived of ACE by using natural or man-made sources of ACE products (enerceuticals), with or without the inclusion of a suitable dye, such as neutral red; and applying the material(s) to the skin, either directly or separated by an impermeable barrier; and illuminating the enerceutical with a UV light source. The process of activating the ACE pathway is evidenced by UV inducible fluorescence seen within areas of the patients' skin and/or mucus membranes. This fluorescence fades as the ACE pathway becomes fully activated. The present patent application shows that neutral red by itself in ethyl alcohol can be used as a suitable enerceutical. Activating the ACE pathway can have therapeutic benefits in various infectious and non-infectious diseases.12-15-2011
20090062718Skin Wound Treatment System, Dressing and Biochemical Activation Device for the Use of Such a System - The present invention relates to a system for treatment of skin wounds, comprising an energy source for activation of a biochemical healing effect, and at least one dressing intended to be placed on the wound before the step of activation by said energy source, characterized in that said dressing comprises an identification means interacting in a contactless manner with a sensor that triggers the function of the energy source only when the distance between the sensor and said identification means is below a threshold value.03-05-2009
20100324469DRUG PRODUCT, A METHOD OF ADMINISTRATING A VACCINE USING THE DRUG PRODUCT, AND AN APPARATUS FOR IONTOPHORESIS - It is an object of the present invention to provide a method and an apparatus capable of noninvasively administrating vaccine through the skin, and thereby making the immune response activate. A drug product according to the present invention is characterized in that the drug product has a support medium, an electrode formed on the support medium and protected partly by an insulating material for avoiding a direct cutaneous contact, a vaccine containing layer for containing a vaccine, wherein the vaccine is an antigen for inducing an immune suppression protein. A method of administrating a vaccine according to the present invention is characterized in that the vaccine is administrated by the iontophoresis using the drug product according to the drug product of the present invention as an electrode. An apparatus for the iontophoresis according to the present invention is characterized in that the drug product according to the present invention is used as an electrode.12-23-2010
20110112465Transdermal Systems for the Delivery of Ionic Agents Directly to Open Wounds and Surgically Repaired Incisions - A transdermal system for the delivery of an anesthetic or other active therapeutic agent directly to a selected site of injured skin tissue by iontophoresis is disclosed, which utilizes a transdermal skin-worn patch including a donor electrode chamber containing a donor electrode and an amount of an active agent in a form suitable for transdermal delivery in electrical communication with the donor electrode and a return electrode. The patch also contains a source of electric current connected in a circuit with the donor and return electrode, a current regulating device is optionally provided in the circuit for controlling the electrical output of the patch and at least the donor electrode chamber includes a provision for absorbing a quantity of fluid associated with weepage from adjacent injured skin tissue.05-12-2011
20110087152FLUIDIC TISSUE AUGMENTATION COMPOSITIONS AND METHODS - Compositions and method for augmenting tissue after delivery to localized area. The compositions include a hydrogel and a dermal filler. The hydrogel can polymerize and/or crosslink upon a first trigger event. The dermal filler can also optionally crosslink upon a second trigger event.04-14-2011
20090312688IONTOPHORESIS DRUG DELIVERY FORMULATION PROVIDING ACCEPTABLE SENSATION AND DERMAL ANESTHESIA - A shelf-stable electrically assisted transdermal drug delivery system for highly effective electrotransport of an anesthetic and a vasoconstrictor producing clinically acceptable dermal anesthesia and sensation is provided. In certain embodiments the anesthetic includes lidocaine and the vasoconstrictor includes epinephrine. Medicament delivery is affected to provide dermal anesthesia with little or no sensation during delivery, as measured by a variety of indicator tests. Methods of producing dermal anesthesia in patients are also provided.12-17-2009
20120041355MULTIPLE SECTION PARENTERAL DRUG DELIVERY APPARATUS - The invention relates to a parenteral therapeutic agent delivery device. The therapeutic agent delivery device has a disposable section and an implant section suitable for long term implantation within the tissue of a subject. When necessary, the disposable section can be detached from the implant section, and a new disposable section can be attached. The disposable section may contain a reservoir containing the therapeutic agent, a pump for dispensing the therapeutic agent, controlling circuitry for regulating the dispensing of the therapeutic agent, and transceiver circuitry and an antenna for wireless communication with external devices.02-16-2012
20120041356PHOTODYNAMIC THERAPY FOR CONDITIONS OF THE EYE - The use of a combination of photodynamic therapy and an anti-VEGF agent in the treatment of conditions characterized by unwanted choroidal neovasculature is described. These conditions include wet age-related macular degeneration Preferred anti-VEGF agents are antibodies such as bevacizumab or ranibizumab Photosensitizers may be selected from green porphyrins such as BPD-MA (verteporfin) and the photodynamic activation of the photo sensitizer may be accomplished using a reduced fluence rate. The use may further comprises an anti-inflammatory agent such as dexamethasone.02-16-2012
20090105633ULTRASOUND ASSEMBLY FOR USE WITH LIGHT ACTIVATED DRUGS - A kit and method for causing tissue death within a tissue site is disclosed. The kit includes a media with a light activated drug activatable upon exposure to a particular level of ultrasound energy. The kit also includes an ultrasound transducer that is configured to transmit the level of ultrasound energy which activates the light activated drug with sufficient power that the ultrasound energy can penetrate the tissue site. The method includes providing the media comprising a light activated drug, delivering the media systematically into a patient's body, providing sufficient time for the light activated drug to localize within the tissue site, and directing ultrasound energy to the light activated drug within the tissue site to thereby activate the light activated drug.04-23-2009
20120150099IONTOPHORETIC TRANSDERMAL DEVICE - An iontophoretic transdermal device includes an applicator, an electric pathway and at least one electrode. The applicator has a first surface and the electric pathway is on the first surface. The electrode is also disposed in the first surface. The electric pathway is electrically connected with the electrode in order to carry the electric current into the electrode. Moreover, the electrode protrudes above the first surface in order to have a direct or indirect contact with the covered skin area substantially without gap.06-14-2012
20090287139IRRITATION-REDUCING OCULAR IONTOPHORESIS DEVICE - The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a pH lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.11-19-2009
20090240189Subdermal material delivery device - A method may include placing a first device on a first side of a skin portion of a subject and transferring a material through the skin portion of the subject from the first device to a subdermal second device disposed on a second side of the skin portion of the subject.09-24-2009
20100174222METHOD AND APPARATUS FOR ACNE TREATMENT USING LOW INTENSITY LIGHT THERAPY - Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the reduction of acne and acne related bacteria using low-intensity light therapy. In an illustrative embodiment, skin containing acne bacteria is treated with a series of pulses of light from a light emitting diode. The LED has a dominant emissive wavelength of about 660 nm and an energy output of about 4 m W. The acne bacteria-containing tissue is exposed to pulses from the light source about 100 times for about 250 milliseconds per pulse, with an interpulse interval of about 100 milliseconds.07-08-2010
20100016783NON-INVASIVE SYSTEMS AND METHODS FOR IN-SITU PHOTOBIOMODULATION - Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.01-21-2010
20100274177Pulsed electromagnetic field and negative pressure therapy wound treatment method and system - A method for treating a wound of an individual and for enhancing a rate of wound healing by applying, for a first period of time, a negative pressure treatment to the wound without applying a pulsed radio frequency treatment; and applying, for a second period of time subsequent to the first period time, a pulsed radio frequency energy treatment to the wound while maintaining the negative pressure treatment to enhance the rate of wound healing. The negative pressure treatment and the pulsed radio frequency energy treatment are applied concurrently for the duration of the second period of time.10-28-2010
20120046597ELECTRODE ARRANGEMENT FOR GENERATING A NON-THERMAL PLASMA - The invention relates to an electrode arrangement (02-23-2012
20120004591METHOD AND APPARATUS FOR FOCUSED RESONANCE NANOPERMEABILIZATION (FORN) - This Invention relates to a method for achieving Focused Resonance Nanopermeabilization (FORN), which can be utilized in a novel anticancer therapy, and other selective permeabilization therapy and a machine to carryout the said method, where the transient permeabilization of cells by Focused Resonance pulses induces a significant increase of anti-tumor drug concentration in tumor or other interested cells. This invention can be successfully applied to the treatment of tumors in humans and Animals by using antimitotic drugs, chemotherapy. The invention is also useful in transpermeabilization of drug molecules for non cancer applications like vaccine and delivery of genetic materials for therapeutic purposes. Focused Resonance Nanopermeabilization (FORN), would enable a practical solution to a whole body application in its natural environment, without implanting electrodes or external probes, FORN is completely non-invasive. This invention also relates to an apparatus for carrying out the above method.01-05-2012
20120109043Integrated skin-treatment specimen dispenser - A device for skin treatment by concurrently applying a series of physical movement such as ultrasound vibration and dispensing a specimen to a target kin area is disclosed. The device includes a skin treatment surface for treating the target skin area, a cartridge containing specimen to be dispensed to the target skin area, an ultrasound generator, a control unit and a power supply. A specimen outlet is on the kin treatment plate. The outlet is coupled to the cartridge.05-03-2012
20100121255COMPOUND - The present invention provides photosensitizing agents obtained by reducing a single double bond in the porphyrin macrocycle of a sulphonated meso-tetraphenylporphyrin, preferably a disulphonated meso-tetraphenylporphyrin such as TPPS05-13-2010
20120310145SYSTEM AND METHOD FOR THE SIMULTANEOUS BILATERAL INTEGRATED TYMPANIC DRUG DELIVERY AND GUIDED TREATMENT OF TARGET TISSUES WITHIN THE EARS - Systems and methods for treating a patient having a head with a first ear and a second ear function by mounting a support system to the head of the patient so that the support system is aligned with a target tissue of the first ear; applying a therapeutic agent to the first car by energizing an iontophoresis electrode supported by the support system; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear.12-06-2012
20120310144VISION THROUGH PHOTODYNAMIC THERAPY OF THE EYE - Photodynamic therapy of conditions of the eye, especially those conditions characterized by unwanted neovasculature, such as age-related macular degeneration, results in enhanced visual acuity for treated subjects.12-06-2012
20120310143IONTOPHORESIS PATCH - An iontophoresis patch is equipped with a donor gel and a reference gel which are disposed to contact an external conductor, for example, the skin of a patient and thereby output current from a current-carrying device to the external conductor. The iontophoresis patch includes: a donor portion having the donor gel containing a medical agent to be penetrated into the external conductor; a reference portion having a reference gel, mounted with the current-carrying device on the surface on the side opposite to the reference gel, and disposed on the external conductor apart from the donor portion; and an electrode film for supplying current from the current-carrying device to the donor gel and the reference gel.12-06-2012
20120310142Drug Delivery System And Method Of Treatment Of Vascular Diseases Using Photodynamic Therapy - This invention relates to photodynamic therapy (PDT) of vulnerable plaque using two pluralities of nanoparticles, one plurality comprising a PDT agent that is sensitive to blue-green light wherein the nanoparticles are capable of penetrating only into the fibrous cap of the vulnerable plaque and one plurality comprising a PDT agent that is sensitive to red light wherein the nanoparticles are capable of penetrating into the core of the vulnerable plaque.12-06-2012
20120310141LIGHT DELIVERY DEVICE AND RELATED COMPOSITIONS, METHODS AND SYSTEMS - Devices and systems for delivering light to a target are described. Methods of using such light delivery device and system are also described. A method of using a photosensitizing compound with the light delivery device is also described.12-06-2012
20120010559ANGIOGENESIS INITIATION AND GROWTH - Methods for promoting angiogenesis comprising administering platelet-rich plasma to a site and stimulating the site with an electromagnetic field. Platelets include platelet-rich plasma and compositions can further include stem cells such as adipose stromal cells and cells derived from bone marrow aspirate. Methods also comprise isolating platelets from a patient's blood, forming a composition including the platelets, delivering the composition to a site in need of treatment, and electrically stimulating the site.01-12-2012
20120010557Drug Delivery System for Use in the Treatment of Vascular and Vessel-Related Pathologies - The present invention relates to a drug delivery system for use in the treatment of vascular and vessel-related pathologies, comprising a drug delivery platform that comprises at least one compound capable of exerting an effect on the formation and/or maintenance of a thrombus in the vessel to be treated. The platform is preferably formed by liposomes that are sterically stabilized by grafting of poly(ethylene glycol) onto the liposome surface. The liposomes may further comprise photosensitizers and targeting molecules. The liposomes may be thermosensitive. The compound is suitably tranexamic acid. The drug delivery system is preferably used for the treatment of port wine stains.01-12-2012
20120010558PHOTOSENSITIZING ANTIBODY-FLUOROPHORE CONJUGATES - The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm01-12-2012
20090149796Use of Iontophoresis and Ultrasound to Deliver Melanin or Other Chromophores for Laser Hair Removal - The method disclosed includes combining iontophoresis and ultrasound to deliver the appropriate chromophores to blonde, grey, white, vellus, and other non-pigmented or laser resistant hair follicles to facilitate photothermolysis hair removal using a laser, Intense Pulsed Light (IPL), a combination of laser and RF energy, or a combination of IPL and RF. This technique preferentially ultra-exposes the hair follicles to light energy which is absorbed preferentially by naturally and synthetic elements in and around the hair follicle. The result is focused photothermolysis damage resulting in death of the hair producing tissue. The combined use of iontophoresis and ultrasound with the appropriate chromophore and laser light allows for immediate and permanent removal of unwanted hair in selected locations on the body of mammals. This combination is so effective that the patient can be treated with single, or at least minimal, office visitations, thereby eliminating the need to continuously prepare and re-prepare the skin with melanin or other chromophores prior to multiple—in office—laser or IPL treatments for completing desired hair removal results. Additionally, this method discloses the use of iontophoresis together with High Intensity Focused Ultrasound (HIFU) and also Radio Frequency (RF) energy combined with High Intensity Focused Ultrasound (HIFU) to specifically provide necrotizing energy doses to target the regenerative zones of the hair and accomplish hair removal.06-11-2009
20120116287PHOTOLABILE COMPOUNDS - The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In one embodiment, the light is visible light, which is not detrimental to the viability of biological samples, such as cells and tissues, in which the released organic molecule is bioactive and can have a therapeutic effect.05-10-2012
20110166500IRRITATION-REDUCING OCULAR IONTOPHORESIS DEVICE - The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.07-07-2011
20110166499METHODS AND APPARATUS FOR INDUCING CONTROLLED RENAL NEUROMODULATION - Methods and apparatus are provided for inducing, monitoring and controlling renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. In some embodiments, tissue impedance, conductance or conductivity may be monitored to determine the effects of pulsed electric field therapy, e.g., to determine an extent of electroporation and its degree of irreversibility. Pulsed electric field electroporation of tissue causes a decrease in tissue impedance and an increase in tissue conductivity. If induced electroporation is reversible, upon cessation of the pulsed electric field, tissue impedance and conductivity should approximate baseline levels; however, if electroporation is irreversible, impedance and conductivity changes should persist. Thus, monitoring of impedance or conductivity may be utilized to determine the onset of electroporation and to determine the type or extent of electroporation. Furthermore, monitoring data may be used in one or more manual or automatic feedback loops to control the electroporation.07-07-2011
20110166498METHODS FOR REDUCING PAIN USING A TRANSDERMAL LOCAL ANESTHETIC PATCH WITH INJECTION PORT IN COMBINATION WITH AN ELECTROMOTIVE FORCE - Described herein are transdermal delivery devices composed of at least one resealable injection port and at least one local anesthetic reservoir. The device effectively delivers anesthetic to the skin of the subject prior to puncturing the skin by syringes, needle sticks, or other instruments intended to be inserted into the skin. In addition, the transdermal delivery device may include a single use patch that does not include a local anesthetic refill port. The devices are used in combination with an electromotive force in order to enhance pain reduction when a subject is injected with a needle. Devices for imparting an electromotive force to a subject are also described herein.07-07-2011
20120065576DRUG DELIVERY SYSTEM - A drug delivery system including a chamber, which is configured for enclosing or covering at least a surface of a patient, a source of a drug and a pressure source, which selectively pressurizes the chamber. In addition, the system includes a controller for controlling the transfer of the drug to the chamber wherein the drug is administered to the surface of the patient under pressure.03-15-2012
20120065573Methods of Treating Vascular Lesions - Described are methods of treating virus-associated lesions using administration of an anti-angiogenic compound, or a combination of angiolytic or ablative therapy and administration of an anti-angiogenic compound.03-15-2012
20120016290LED-BASED SKIN TREATMENT SYSTEM AND METHOD - Provided are an LED-based skin treatment system capable of performing a skin treatment in consideration of individuals' respective skin properties and a reaction of skin to a change in a patient's emotional state by using an LED light source, and a method thereof. The LED-based skin treatment system includes a skin diagnosis unit ascertaining a patient's skin properties and an extent of a skin reaction to a change in a patient's emotional state by using multiple sensors, and diagnosing a skin lesion and an extent thereof and a skin lesion occurrence location; a skin treatment unit controlling an output state of an LED light source according to the skin lesion and the extent thereof and the skin lesion occurrence location; and a hardware control unit driving the multiple sensors and the LED light source.01-19-2012
20120016289ARTICLES, COMPOSITIONS, AND METHODS FOR KILLING OR PREVENTING THE GROWTH OF MICROBES - Described herein are methods and compositions for killing or preventing the growth of microbes. It has been discovered that a class of porphyrins can kill or prevent the growth of microbes. The porphyrins can be used in a number of different applications where microbes grow.01-19-2012
20120022431Iontophoretic Drug Delivery Packaging - The present invention relates generally to iontophoretic drug delivery systems for transdermal delivery of therapeutic agents and, more particularly, to packaging such systems for long shelf life and easy assembly for use. The system package includes an iontophoretic skin worn patch component that accommodates a power source, electronics, electrodes and a drug pack component that carries a therapeutic agent which is contained as a separate sealed component. The packaged system further provides for ease of assembly at the time of use.01-26-2012
20120022432GAS MIST PRESSURE BATHING SYSTEM - The present invention is to provide a gas mist pressure bathing system enabling to cause a gas mist to be absorbed into the skin and the mucous membrane of the living organism under an optimum condition of controlling the amounts of gas and liquid. The system comprises a gas supply means 01-26-2012
20120022433METHODS FOR INCREASING TRICHOGENICITY OF DERMAL CELLS - Methods for increasing trichogenic activity of populations of dermal cells by inducing local trauma to skin tissue that serves as a source of the dermal cells are provided. Methods for obtaining dermal cells with increased trichogenic activity and for using the disclosed dermal cells to implant into a mammalian host at a site of desired follicle generation are also provided.01-26-2012
20120059307Compositions and Methods for Targeted Thermomodulation - Provided are nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans.03-08-2012
20120065574ISOFORM NELL-1 PEPTIDE - This application generally relates to an isoform Nell-1 peptide, compositions thereof, and methods of using the same.03-15-2012
20120116288ELECTROPORATION DEVICE WHICH REDUCES MUSCLE CONTRACTION AND PAIN SENSATION - An electroporation device comprising pulses generating circuit (05-10-2012
20110092881IONTOPHORETIC DEVICE WITH CONTACT SENSOR - The present application discloses an iontophoretic device with a contact electrode for detecting placement of the device and/or characteristics of the wearer's tissue.04-21-2011
20110092880ENERGETIC MODULATION OF NERVES - A method of treatment includes delivering an agent into a patient, and providing energy inside the patient so that the energy can interact with the agent to treat a nerve. A system for treatment includes a source of agent for delivery into a patient, and an energy source for providing energy inside the patient so that the energy can interact with the agent to treat a nerve.04-21-2011
20120071810PHOTODYNAMIC THERAPY INCLUDING LIGHT PRETREATMENT - A method of photodynamic therapy is described that includes administering a therapeutically effective amount of a photosensitizer to an area of tissue such as the skin of a subject, delivering a first photoirradiation with light having a wavelength suitable to activate the photosensitizer to the area of skin, allowing a sufficient interval of time to pass for an effective amount of the photosensitizer to penetrate the tissue, and then delivering a second photoirradiation with light having a wavelength suitable to activate the photosensitizer to provide a therapeutic effect. Use of multiple photoirradiations increases the speed with which the photosensitizer can penetrate the tissue to reach the area where the source of the disease is present.03-22-2012
20120071811STIMULATION METHOD FOR THE SPHENOPALATINE GANGLIA, SPHENOPALATINE NERVE, OR VIDIAN NERVE FOR TREATMENT OF MEDICAL CONDITIONS - A method is provided for suppressing or preventing pain in a patient. One step of the method includes positioning first and second electrodes, without penetrating the cranium, on or proximate to at least one of the sphenopalatine ganglia, the sphenopalatine nerves, or the vidian nerves on both sides of the patient's face. At least one of a medication solution, an analgesic, or an electrical signal is then applied to at least one of the sphenopalatine ganglia, the sphenopalatine nerves, or the vidian nerves through the first and second electrodes. Pain signal generation in, or transmission through, the at least one of the sphenopalatine ganglia, sphenopalatine nerves, or vidian nerves is disrupted on both sides of the patient's face.03-22-2012
20120109041APPLICATOR DEVICE FOR COSMETIC AND/OR MEDICAL USE - The invention relates to an applicator device, comprising an applicator element (05-03-2012
20110066101NON-INVASIVE OCULAR DRUG DELIVERY - The present invention is drawn to a pharmaceutical compound for the treatment of posterior retinal diseases through topical application of the compound. The compound includes an effective amount of a therapeutic compound, and at least one additional agent that helps to prolong the residence time of the therapeutic compound within the extraocular space, or increase the transport of the therapeutic compound across a tissue of an eye toward and into a posterior ocular region, or both. The invention is additionally drawn to a device and method for delivering the compound.03-17-2011
20110066100METHODS FOR IONTOPHORETICALLY TREATING NAUSEA AND MIGRAINE - Methods for treating nausea and migraine by iontophoretically administering triptan compounds are provided.03-17-2011
20110105996METHODS FOR SCAR PREVENTION - Provided herein are compositions and methods for preventing or reducing scar formation (e.g., hypertrophic scars). For example, provided herein are methods of administrating HMG-CoA-inhibiting agents for preventing or reducing scar formation.05-05-2011
20110105995UNIFORM-SIZED, MULTI-DRUG CARRYING, AND PHOTOSENSITIVE LIPOSOMES FOR ADVANCED DRUG DELIVERY - Uniform-sized liposome populations can improve both the efficacy and safety of drug delivery. The present invention utilizes the techniques of extrusion with polycarbonate-membrane-based large-pore dialysis to create uniform-sized liposome populations. These uniform-sized liposome populations may comprise different sizes such that smaller liposome populations contain specific drugs that are compartmentalized within a larger liposome population. These uniform-sized liposomes can be lysed upon photoillumination and release the encapsulated drugs and/or smaller liposomes, and can be used as a new version of photodynamic therapy.05-05-2011
20100094197EYE THERAPY SYSTEM - In a system for stabilizing a pattern of structural changes in corneal fibrils, an eye treatment system causes corneal fibrils of a cornea of an eye to transition from a first structure to a second structure. An application device applies a cross-linking element to the corneal fibrils. An activating device applies an initiating element to the corneal fibrils and activates the cross-linking element. The cross-linking element causes cross-linking in the corneal fibrils to preserve the second structure of the corneal fibrils. Another application device may apply a cross-linking breaker to the corneal fibrils. The cross-linking breaker halts or reverses at least partially the cross-linking in the corneal fibrils. Another activating device applies an initiating element to the corneal fibrils and activates the cross-linking breaker. Advantageously, the cross-linking breaker provides greater control over the amount and progress of cross-linking that occurs in the corneal fibrils.04-15-2010
20120150098Method and System for Mitigating Current Concentration in Electrokinetic Drug Delivery - An electrokinetic apparatus to apply medicament to a treatment site of a mammalian user, the apparatus including: a segmented active electrode; a medicament matrix having one side abutting the segmented active electrode and another side adapted to contact a surface of skin over the treatment site, wherein the matrix includes at least one current direction barrier suppressing transverse current flow through the matrix.06-14-2012
20120123319 SONOTRODE - Disclosed are a sonotrode and its use for transdermal delivery of therapeutic or cosmetic compounds. The sonotrode 05-17-2012
20120123318MICROELECTRODE AND MULTIPLE MICROELECTRODES - A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use.05-17-2012
20100241059METHOD AND PORTABLE DEVICE FOR TREATING SKIN DISORDERS - A device for treating a skin condition is provided. The device comprises a delivery system for administering a composition to the skin disorder. The delivery system includes an electrode for delivering a composition to the skin of a person and a counter electrode. The device also includes a drainage system which includes a channel for removing material from a person's skin and a pump in communication with the channel The device further includes a control system for powering and controlling the electrode system.09-23-2010
20100241058OCT GUIDED TISSUE ABLATION - A method and system of ablating tissue under optical coherence tomography guidance including inserting an optical coherence tomography catheter into a patient's vasculature; navigating the catheter to a target site; imaging and mapping target tissue at the target site using the catheter; delivering a light-activated therapeutic agent into the target tissue; and illuminating the light-activated therapeutic agent with light emitted from the catheter, thereby activating the therapeutic agent and ablating the target tissue; establishing coordinates of the target tissue under computer tomography imaging whereby the catheter provides a marker visible under computer tomography imaging for establishing a positional relationship between the catheter and the target tissue, establishing a localized magnetic field in the target tissue on the basis of the coordinates obtained during the computer tomography imaging and where the light-activated therapeutic agent is magnetized and substantially retained within the target tissue by way of the localized magnetic field.09-23-2010
20100241057 APPARATUS FOR IONTOPHORESIS - The present invention relates to an iontophoresis apparatus, and more particularly, to an iontophoresis apparatus detachable from a mask or patch, wherein after skin condition is previously diagnosed before an iontophoresis is performed, the amount of current is adjusted according to the skin condition to absorb effective components contained in functional cosmetics or medicines into the skin, and a plurality of electrode pairs are applied to use interference current generated between the electrode pairs thereby accelerating absorption of the effective components and improving the skin condition.09-23-2010
20100241056FACE MASK - A face mask for cleansing of facial skin. The face mask 09-23-2010
20120172783OBESITY THERAPY AND HEART RATE VARIABILITY - Methods and devices are provided for delivering obesity therapy to a patient. In general, the methods and devices allow for onset of a patient eating solid food, e.g., the patient beginning a meal, to trigger delivery of an obesity therapy to a patient. The obesity therapy can be delivered to the patient for a limited period of time such that the patient stops receiving the obesity therapy prior to a second onset of the patient eating solid food, e.g., the patient beginning a second meal, which can trigger a second delivery of the obesity therapy to the patient for a limited period of time.07-05-2012
20120232464IONTOPHORETIC SYSTEM FOR TRANSDERMAL DELIVERY OF ACTIVE AGENTS FOR THERAPEUTIC AND MEDICINAL PURPOSES - An embodiment of a system includes a power source and at least two electrode assembles. The power source that an output current that alternates between a maximum current value and a minimum current value; a pair of electrode assemblies. Each electrode assembly is configured to be held in contact with a skin layer of a user. Additionally, each electrode assembly includes an electrode that is coupled to the power source to receive the output current from the power source. At least one of the electrode assemblies in the pair includes a medium that carries an active agent having a charge, the medium being provided on the at least one electrode assembly to enable the output current to repel the active agent into the skin layer for a duration in which the output current has a polarity that is the same as a polarity of the active agent.09-13-2012
20120232463DE NOVO SYNTHESIS OF BACTERIOCHLORINS - A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II09-13-2012
20120130302ACTIVE RETINAL IMPLANT - An active retinal implant (05-24-2012
20120130303RATE CONTROL DURING AF USING CELLULAR INTERVENTION TO MODULATE AV NODE - A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K05-24-2012
20120238942Transdermal therapeutic System for the Administration of Peptides - The invention relates to a transdermal therapeutic system (TTS), which is suited for the administration of a peptide to a patient through skin treated with ablation. The transdermal therapeutic system includes a back layer and an active substance-containing layer that contains at least one peptide and a carrier substance, preferably as a textile web material.09-20-2012
20120215155CONTROLLED CROSS-LINKING INITIATION AND CORNEAL TOPOGRAPHY FEEDBACK SYSTEMS FOR DIRECTING CROSS-LINKING - Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.08-23-2012
20100204638IRREVERSIBLE ELECTROPORATION AND TISSUE REGENERATION - A method and device are herein described to treat a target region of tissue, using at least one energy delivery device coupled to a power source and positioned in a treatment position so as to irreversibly electroporate tissue to ablate a target region, and introduce regenerative materials into a treated region.08-12-2010
20120136296METHODS TO REGULATE POLARIZATION AND ENHANCE FUNCTION OF EXCITABLE CELLS - Minimally invasive delivery with intercellular and/or intracellular localization of nano- and micro-particle solar cells within and among excitable biological cells to controllably regulate membrane polarization and enhance function of such cells. The cells include retinal and other excitable cells.05-31-2012
20120215154SYNTHESIS OF 2-(4-AMINOPHENYL) BENZOTHIAZOLE DERIVATIVES AND USE THEREOF - The present invention provides a method of preparing a compound of formula 608-23-2012
20120136295PHARMACEUTICAL COMPOSITION - To provide a pharmaceutical composition containing a 2-nitroimidazole derivative, which has high solubility in an aqueous carrier and high stability.05-31-2012
20110184336DEVICE FOR PHOTODYNAMICAL THERAPY OF CANCER - A photodynamic therapeutic device for treating cancer is disclosed. The therapeutic device comprises at least one light emitting diode attachable to a patient's body adapted to provide an effective light fluence to a lesion area. The therapeutic device further comprises an annular structure embracing the patient's body and a passage connectable to a cooling loop providing a coolant circulative into the passage. The light emitting diode is secured to an inner surface of the annular structure. The coolant accommodated in the passage is adapted for removing heat generated by the light emitting diode.07-28-2011
20110184335MULTI-CHANNEL CONNECTOR FOR BRAIN STIMULATION SYSTEM - An implantable connector for use with a neurological device and a lead extension includes a male connector having a plurality of electrical contacts axially arranged along the connector, insulated from each other. The connector also includes a female connector having one or more channels axially disposed therein and a plurality of conductors axially arranged on the female connector. The plurality of conductors are electrically insulated from each other, and at least one indexing element is disposed adjacent to one or more of the channels. The indexing element allows the male connector to be received into the one or more channels in a defined orientation relative to the channel, thereby forming at least two electrical connections along two or more axial positions. Often the neurological device is a brain stimulating and recording lead. The male and female connectors are often fastened together with a screw or by twist-locking the two members together.07-28-2011
20110184334PHOTOTREATMENT DEVICE FOR USE WITH COOLANTS AND TOPICAL SUBSTANCES - Methods and systems are disclosed for phototreatment in which replaceable containers comprising one or more adjuvant (consumable or re-usable) substances are employed. The adjuvant substance can be, for example, a topical substance or a coolant. Systems are disclosed for using a topical substance to detect contact of a phototreatment device with a tissue, detect speed of a phototreatment device over the tissue, detect regions of tissue that have been treated by a phototreatment device and/or to provide other benefits to the tissue such as improved skin tone and texture, tanning, etc. Safety systems are also disclosed that ensure that a proper consumable substance and/or container is connected to a phototreatment device and/or directed to a proper target. Additionally, cooling systems and methods that utilize phase change materials for extracting heat from a light generating device are disclosed.07-28-2011
20110184333PHOTOLABILE CAGED TRANSITION METAL COMPLEXES AND METHODS OF USING THE SAME - The present invention provides compounds of Formula I: (I) along with compositions comprising the same and methods of using the same, such as for photodynamic therapy in the treatment of cancer.07-28-2011
20090187134Iontophoresis Device Controlling Amounts of a Sleep-Inducing Agent and a Stimulant to be Administered and Time at Which the Drugs are Administered - An iontophoresis device includes an electric power source device, a drug administration device and a current control device. The drug administration device may include at least two or more electrode assemblies each holding an ionic drug. The drug administration device may be coupled to the electric power source device. The current control device may control current flowing to respective ones of the electrode assemblies. An amount of the ionic drug is releasable from each of the electrode assemblies at a defined time when transdermally administered to an organism in accordance with the current flowing from the current control device, wherein at least one of the two or more electrode assemblies holds a sleep-inducing agent as the ionic drug, and at least another one of the two or more electrode assemblies holds a stimulant as the ionic drug.07-23-2009
20100174223METHOD AND APPARATUS FOR OPTICAL INHIBITION OF PHOTODYNAMIC THERAPY - A system and method are provided for preventing damage to the epidermis or other epithelial or non-target tissue during photodynamic therapy treatment. For example, an inhibiting radiation can be used to control formation of a photosensitizer from a precursor photosensitizer in the epidermis or epithelial tissue. Subsequent application of a treatment radiation can activate the photosensitizer to damage or destroy target sites while the non-target tissue remains substantially unaffected.07-08-2010
20120172784DEVICE FOR TREATING TISSUE - An apparatus for use in carrying out a prophylactic or treatment procedure on tissue comprises a head piece 07-05-2012
20120215156SELECTIVE RESONANCE OF BODILY AGENTS - Chemical compositions may be selectively or preferentially excited by the application of scores comprising a series of energy inputs.08-23-2012
20120220923Iontophoresis Methods - A method of anesthetizing a tympanic membrane of an ear of a patient using iontophoresis is disclosed. The method involves delivering an anesthetizing drug solution to an ear canal of the patient's ear, wherein the drug solution includes an anesthetic and a buffer, and wherein the drug solution has a pH in the range of about 6.5 to about 7.5; and applying an amount of current to the drug solution, wherein the amount of applied current is increased at a rate of less than about 0.5 milliamp per second until a maximum current is achieved.08-30-2012
20120220922PHOTOLABILE COMPOUNDS - The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In some embodiments, the Photolabile Compounds comprise a light antenna, such as a labeling molecule or an active derivative thereof. In one embodiment, the light is visible light, which is not detrimental to the viability of biological samples, such as cells and tissues, in which the released organic molecule is bioactive and can have a therapeutic effect. In another embodiment, the photoreleasable ligand can be a labeling molecule, such as a fluorescent molecule.08-30-2012
20120220921IMMUNOLOGICALLY MODIFIED CARBON NANOTUBES FOR CANCER TREATMENT - A method for constructing a compound of immunologically modified nanotubes and method for using the compound to deliver immunoadjuvants to tumor cells and to produce targeted, synergistic photophysical and immunological reactions for cancer treatment. To prepare the immunologically modified nanotubes, carbon nanotubes are dissolved in a solution of glycated chitosan, an immunostimulant, hence using glycated chitosan as a surfactant for rendering the aqueous solution of nanotubes stable. The compound can be used for treatment of cancer. The method includes steps of intratumorally administering immunologically modified nanotubes and administering laser irradiation of the target tumor. The nanotube serves as a carrier to deliver immunoadjuvants to the tumor cells and serves as a light-absorbing agent in a cell body of a tumor in a host. Upon laser irradiation of target tumor cells, immunologically modified nanotubes inside the tumor cells can produce spatially and temporally synchronized photothermal and immunological reactions for cancer treatment.08-30-2012
20100298761ELECTROPORATION DEVICE WITH IMPROVED TIP AND ELECTRODE SUPPORT - An electroporation device having a handle section, a set of electrodes, and an electrode guide assembly. The handle section is operatively connected to an elongate introducer shaft, which has a longitudinal axis and a distal tip. The set of electrodes includes respective distal electrode tips. The electrode guide assembly is arranged inside the elongate introducer shaft and includes a set of electrode channels with each electrode channel guiding one or several electrodes. Each electrode is slidably arranged within an electrode channel between (a) a retracted position, where the distal electrode tips are enclosed inside the introducer shaft, and (b) an advanced position, where the distal electrode tips project to an outside of the introducer shaft. A set of longitudinally extending tip electrode channels are arranged in the distal tip and adapted to guide respective travel trajectories of the distal electrode tips during electrode advancement and retraction. The set of longitudinally extending tip electrode channels includes a set of electrode grooves disposed around a circumferential contour of a rotationally symmetrical member of the distal tip.11-25-2010
20100298759 ELECTROPORATION DEVICE FOR IMPROVED ELECTRICAL FIELD CONTROL - An electroporation device and method having a plurality of electrotherapeutic devices for insertion into and surrounding a sensitive target tissue e.g. the brain of a patient where the electroporation device and the electrotherapeutic devices are adapted for applying a precisely controlled electrical field, and to avoid or limit damages to the healthy tissue surrounding the target tissue to be treated.11-25-2010
20100298757ADJUVANT ENHANCED ABLATION - An adjuvant applicator comprises a balloon coupled to a distal end of a tube. The balloon has an inflated state and a deflated state. The exterior surface of the balloon includes a coating of an adjuvant. In one embodiment, the adjuvant is configured to absorb energy from laser light. In a method, the adjuvant applicator is provided. The balloon is inserted into the patient adjacent target tissue. The coating of adjuvant is then applied to the target tissue using the adjuvant applicator by inflating the balloon to the inflated state, which places the adjuvant in contact with the target tissue. Next, the balloon is removed from the patient and the adjuvant coated tissue is exposed to laser light. In one embodiment, the exposure of the adjuvant coated tissue to the laser light ablates the target tissue.11-25-2010
20120179089SUBSTITUTED BIPYRIDINES FOR USE IN ORGANIC LIGHT-EMITTING DEVICES - Optionally substituted bipyridine compounds, optionally substituted phenylbipyridine compounds, or optionally substituted bis-phenylbipyridine compounds may be useful in light-emitting devices. Some examples include, but are not limited to, optionally substituted 4-(5-(6-(4-(diphenylamino)phenyl)pyridin-3-yl)pyridin-2-yl)-N,N-diphenylbenzenamine, optionally substituted 9-(4-(5-(6-(4-(9H-carbazol-9-yl)phenyl)pyridin-3-yl)pyridin-2-yl)phenyl)-9H-carbazole, optionally substituted 4-(5-(6-(benzo[d]thiazol-2-yl)pyridin-3-yl)pyridin-2-yl)-N,N-diphenylbenzenamine, optionally substituted 4-(5-(6-(benzo[d]oxazol-2-yl)pyridin-3-yl)pyridin-2-yl)-N,N-diphenylbenzenamine, optionally substituted N,N-diphenyl-4-(5-(6-(1-phenyl-1H-benzo[d]imidazol-2-yl)pyridin-3-yl)pyridin-2-yl)benzenamine, optionally substituted 4-(5-(6-(4-(9H-carbazol-9-yl)phenyl)pyridin-3-yl)pyridin-2-yl)-N,N-diphenylbenzenamine, optionally substituted 2-(5-(6-(benzo[d]thiazol-2-yl)pyridin-3-yl)pyridin-2-yl)benzo[d]thiazole, optionally substituted 2-(5-(6-(benzo[d]thiazol-2-yl)pyridin-3-yl)pyridin-2-yl)benzo[d]oxazole, optionally substituted 9-(4-(5-(6-(benzo[d]thiazol-2-yl)pyridin-3-yl)pyridin-2-yl)phenyl)-9H-carbazole, optionally substituted 9-(4-(5-(6-(benzo[d]oxazol-2-yl)pyridin-3-yl)pyridin-2-yl)phenyl)-9H-carbazole, optionally substituted 9-(4-(6′-(1-phenyl-1H-benzo[d]imidazol-2-yl)-3,3′-bipyridin-6-yl)phenyl)-9H-carbazole, and 6,6′-bis(9-phenyl-9H-carbazol-3-yl)-3,3′-bipyridine.07-12-2012
20120179091GELS WITH PREDETERMINED CONDUCTIVITY USED IN ELECTROPORATION OF TISSUE - Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.07-12-2012
20120179090TRANSMUCOSAL DELIVERY OF THERAPEUTIC AGENTS AND METHODS OF USE THEREOF - Described herein is a transmucosal delivery device and their use for delivering bioactive agents across a mucosal membrane. The delivery devices contain a pharmaceutically acceptable oxidizing and agents that facilitates the delivery of the blood stream across the mucosal membrane.07-12-2012
20100274176WOUND CARE SYSTEM AND BACTERICIDAL METHODS AND DEVICES - A variety of article and systems including wound care systems, methods for making the wound care systems, bactericidal, and methods for treating wounds using these systems are disclosed. The wound care systems may include a first material comprising one or more fibers or porous media. The one or more fibers or porous media may be coated with a second material that is capable of inhibiting the growth of bacteria and killing the bacteria to render the wound care system sterile, increasing the absorbency of the first material, or both upon exposure to light. The first material may be cotton, or any suitable fibrous material, the second material may be TiO10-28-2010
20100174224HANDHELD TRANSDERMAL DRUG DELIVERY AND ANALYTE EXTRACTION - Apparatus is provided for facilitating delivery of a substance through skin of a subject. The apparatus includes a handle and a cartridge, removably coupled to the handle. The cartridge includes one or more electrodes and a patch comprising the substance, the electrodes adapted to be applied to a region of the skin, and the patch adapted to be applied to at least a portion of the region of the skin by removal of the electrodes therefrom.07-08-2010
20100030129DERMAL PATCH - The invention is generally directed to a kit and patch for transdermal or intradermal delivery of at least one substance into the skin. The kit includes a dermal patch having an electrochemical cell with two electrodes and a retainer for retaining a conductive fluid which further includes an active substance. The conductive fluid can be deposited on at least one of the two electrodes. Alternatively, the conductive fluid can be applied topically to the skin.02-04-2010
20120253264PHOTOCHEMICAL INTERNALIZATION METHOD - The invention relates to methods of introducing drugs into cells which are located in body cavities. In particular, it provides a photosensitizing agent for use in a method of introducing a drug molecule into the cytosol of a cell located within a body cavity, said method comprising the step of contacting said cell with said photosensitizing agent and said drug molecule, and irradiating the cell with light of a wavelength effective to activate the photosensitizing agent. Such methods are particularly suitable for use in the delivery of cytotoxic drugs in the treatment of cancer, especially bladder cancer, ovarian cancer, cervical cancer, lung cancer, brain cancer, colorectal cancer and cancers of the oral and nasal cavity.10-04-2012
20120253262Switch Validation Circuit and Method - A switch operated therapeutic agent delivery device is described. Embodiments of the operated therapeutic agent delivery device include a switch that can be operated by a user, a device controller connected to the switch through a switch input where the device can actuate the device when certain predetermined conditions are met, and a switch integrity subcircuit which is used to detect a fault or a precursor to a fault.10-04-2012
20120253263Two-Part Electrotransport Device - A switch operated therapeutic agent delivery device is described. The device comprises two parts, which are assembled by a user prior to use. A first part contains a power supply and circuitry for the device; and a second part comprises electrodes and reservoirs containing the therapeutic agent to be delivered. The action of combining the two parts of the device causes the two parts to be irreversibly coupled together, completes an electrical connection between the two parts, and closes one or more switches, thereby connecting a power source, such as a battery, into the device's circuitry, thereby powering the device on so that it is ready for use. The device can then be attached to a patient, who can operate the device by pressing a button in a proper sequence.10-04-2012
20090326434Anti-Microbial Photodynamic Therapy - Antimicrobial molecular conjugates for the treatment and prevention of infectious diseases caused by pathogenic microorganisms in human and animals are provided. The key to these conjugates is a special spacer connecting at least one photosensitizer to a microorganism receptor (vector) which in turn binds selectively to the surface of a microorganism bringing about photo-destruction upon irradiation. Spacers having hydrophilic structure such as ethylene glycol units and amino carboxyl end capped ethylene glycol units must be used for linking the vector to the photosensitizer. In a preferred embodiment a spacer would have at least 3 ethylene glycol units and be end capped with a carboxyl group on one end and a amino group at the other end. The present invention effectively works to combat bacterial infection in the real patient-related environments where blood, serum and other body fluids are always present or at least nearby. Spacers of selected length and structure, in preferred embodiments, are used for linking the vector to the photosensitizer. These conjugate are found to be very effective in combating bacterial infection in the real patient-related environments where blood, serum and other body fluids are always present or a least nearby. A method of use is also provided.12-31-2009
20120220920METHOD OF STIMULATING HAIR GROWTH - A method of stimulating growth of a hair shaft from a hair follicle on a scalp of a human includes supplying a hair growth system. The hair growth system includes a vitamin complex ingestible by the human, a cleansing agent suitable for washing the scalp at least once every 48 hours and substantially free from each of sodium lauryl sulfate, palmitoyl ethanolamide, and dehydroepiandrosterone, and a plurality of laser diodes disposed in a fixture. The fixture is configured for surrounding the scalp and applying electromagnetic radiation to the scalp. The method also includes applying electromagnetic radiation having a wavelength of from about 380 nm to about 1,000 nm to the scalp at a radiant flux of from about 600 nW to about 700 nW via the plurality of laser diodes to stimulate growth of the hair shaft from the hair follicle. A hair growth system is also disclosed.08-30-2012
20120226219DEVICE AND IONTOPHORESIS PATCH COMPRISING THIN FILM BATTERY - An apparatus having a thin film battery includes: a device electrically operating and including a substrate; and the thin film battery for supplying power to the device. The thin film battery includes: a first electrically conductive layer formed on the substrate; a second electrically conductive layer formed on the substrate while being spaced apart from the first electrically conductive layer and positioned on an identical plane to the first electrically conductive layer; a first electrode layer formed on the first electrically conductive layer and electrically connected to the first electrically conductive layer; a second electrode layer formed on the second electrically conductive layer, electrically connected to the second electrically conductive layer, disposed while being spaced apart from the first electrode layer in a side direction, and having a polarity opposite to a polarity of the first electrode layer; an ion conductive polymer electrolyte for covering both the first electrode layer and the second electrode layer; and a sealing film for sealing the ion conductive polymer electrolyte.09-06-2012
20120226218EXTRACELLULAR MATRIX MATERIAL CREATED USING NON-THERMAL IRREVERSIBLE ELECTROPORATION - Extracellular matrix material is disclosed which is created by subjecting a target area to non-thermal irreversible electroporation (NTIRE) with a pulsed electrical field to kill cells in the absence of thermal damage. The dead cellular material may be removed and the remaining non-cellular matrix material may be implanted into a repair site to be treated medically or cosmetically.09-06-2012
20120259266WOUND CARE METHOD AND SYSTEM WITH ONE OR BOTH OF VACUUM-LIGHT THERAPY AND THERMALLY AUGMENTED OXYGENATION - A combination therapy pad that includes a first layer and a second layer operatively coupled to the first layer. A fiber-optic array is disposed between the first layer and the second layer. A third layer is operatively coupled to the first layer. The third layer includes a vacuum tube in fluid communication with a vacuum source and a therapeutic fluid tube in fluid communication with a therapeutic fluid source. The third layer provides at least one of vacuum therapy and therapeutic fluid treatment to a wound area.10-11-2012
20120238940CYCLOOXYGENASE INHIBITOR AND CALCIUM CHANNEL ANTAGONIST COMPOSITIONS AND METHODS FOR USE IN UROLOGICAL PROCEDURES - Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.09-20-2012
20120259267Chemically Amplified Response Strategies for Medical Sciences - Compositions are provided in which dendrimers and/or nanoparticles are synthesized with multi-photon responsive elements and self-immolative oligomers. The compositions may be utilized to selectively deliver Payloads within tissue by irradiating the compositions. The compositions may also be used to amplify sensitivity to irradiation.10-11-2012
20100191171Iontophoresis device - The iontophoresis device according to the exemplary embodiment of the present invention may concentrate care skin to where liver spots and freckles exist, and may be compact, portable, and convenient. An iontophoresis device according to an exemplary embodiment of the present invention may include: a housing providing an inner space; a battery installed in the housing for supplying power; a control circuit for controlling a current output from the battery; a first contact portion electrically connected with the battery and contacting the skin; a second contact portion electrically connected with the battery and disposed to the housing; and an operation portion for turning the power on and off.07-29-2010
20100312168LONG LIFE HIGH CAPACITY ELECTRODE, DEVICE, AND METHOD OF MANUFACTURE - Electrodes, particularly electrochemically active electrodes, may benefit from one or more pretreatment cycles in which the electrode is substantially oxidized, reduced or otherwise exhausted prior to use in an end use application, for example active agent delivery via iontophoresis. For instance, electrode lifetime may be advantageously increased, even when used to delivery relatively high currents or used at high current densities. Such may be necessary to delivery therapeutically effect dosage regimes, for instance of oxycodone. Use of a nonwoven fibrous substrate printed with a sacrificial ink may be advantageous relative to other substrates. Use of certain Ag/AgCl inks may be advantageous over other Ag/AgCl inks.12-09-2010
20120238941Treatment of Alopecia By Micropore Delivery of Stem Cells - A method of restoring hair to skin that has suffered hair loss includes optically ablating an array of spaced-apart microchannels or voids into the skin and transplanting into the voids stem cells, a scaffold and a differentiation factor for causing the stem cells to differentiate into hair follicles.09-20-2012
20120238939DEVICE FOR IRRADIATING ACTINIC RADIATION OF DIFFERENT WAVELENGTHS - Described is a device for irradiating a body with actinic radiation. The device comprises one or more elements allowing the person to stand, sit or lie in a position allowing said actinic radiation to impinge on at least a part of the body; one or more elements allowing control of the intensity, irradiance, dose, and/or time of irradiation of said actinic radiation; and one or more elements comprising at least one source of radiation that emits radiation of at least two different wavelengths, at least one of the wavelengths being in the visible range.09-20-2012
20120238938METHOD AND APPARATUS FOR THE DELIVERY OF PHOTO-CHEMICAL (CROSS-LINKING) TREATMENT TO CORNEAL TISSUE - Systems and methods for delivering and infusing formulations containing riboflavin or its analogues, or other ophthalmic formulations, into corneal tissue are disclosed. Systems and methods are further disclosed to cross-link the corneal tissue through exposure to UVA irradiation. The systems and methods for formulation delivery employ micro-needle array delivery devices.09-20-2012
20120238937METHOD OF TREATING KELOIDS OR HYPERTROPHIC SCARS USING ANTISENSE COMPOUNDS TARGETING CONNECTIVE TISSUE GROWTH FACTOR (CTGF) - This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described.09-20-2012
20120265121PHTHALOCYANINE-BASED ANTIFUNGAL AGENTS - A method is described for the photodynamic treatment of a fungal infection in a subject by administering a therapeutically effective amount of a phthalocyanine compound or a pharmaceutically acceptable salt thereof to the subject and activating the phthalocyanine compound with light. The method is useful for treating various dermatophyte infections such as onychomycosis, and in particular fungal infection by 10-18-2012
20120265122Production of Graphene and Nanoparticle Catalysts Supposrted on Graphen Using Laser Radiation - Methods and apparatuses to produce graphene and nanoparticle catalysts supported on graphene without the use of reducing agents, and with the concomitant production of heat, are provided. The methods and apparatuses employ radiant energy to reduce (deoxygenate) graphite oxide (GO) to graphene, or to reduce a mixture of GO plus one or more metals to to produce nanoparticle catalysts supported on graphene. Methods and systems to generate and utilize heat that is produced by irradiating GO, graphene and their metal and semiconductor nanocomposites with visible, infrared and/or ultraviolet radiation, e.g. using sunlight, lasers, etc. are also provided.10-18-2012
20120265120Systems and methods for reducing the proliferation of microorganisms - Systems and methods are provided that reduce the likelihood of infection caused by microorganisms. In general, microorganism population control can be achieved by exposing the population to an effective dose of electromagnetic radiation sufficient to cause a reduction in proliferation of the microorganism, wherein the electromagnetic radiation has a center wavelength between about 385 nm and about 425 nm. In preferred embodiments, the systems and methods described herein can be embodied in catheterization systems.10-18-2012
20120265119Transdermal Delivery of Medicinal Cetylated Fatty Esters using Phonophoresis or Iontophoresis - The use of phonophoresis or iontophoresis to enhance transdermal delivery of medicinal Cetylated fatty esters when applied in cream or gel compositions is disclosed. These compositions provide hydrophilic salt forms and penetration-enhancing vehicles that work in conjunction with phonophoresis or iontophoresis to increase the efficacy of the medicinal actives.10-18-2012
20110046539INTERNAL MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH A SOURCE OF ELECTRICAL POWER - The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.02-24-2011
20110046538COMBINATION OF A LIGHT RAY WITH A CYTOCHROME C OXIDASE SUBSTRATE PARTICULARLY FOR IMPROVING THE APPEARANCE OF THE SKIN AND/OR HAIR - The invention relates to the combination of a light ray with a cytochrome C oxydase substrate particularly for improving the appearance of the skin and/or the hair. The invention more particularly relates to a method for a cosmetic treatment particularly for improving the appearance of the skin and/or the hair that comprises the simultaneous and/or sequential administration of a) at least one cytochrome C oxydase substrate and/or at least one agent increasing the expression of said substrate; and b) at least one light radiation having at least one predominant wavelength that activates the cytochrome C oxydase. More particularly, said light radiation has at least one predominant wavelength activating the cytochrome C oxydase, that ranges from 550 to 1000 nm, in particular from 550 to 800 nm, preferably from 620 to 700 nm, and more preferably from 640 to 680 nm; the method comprises applying a dose preferably ranging from 0.01 to 200 J/cm2, preferably from 0.1 to 30 J/cm2, more preferably from 1 to 30 J/cm2, or even from 5 to 30 J/cm2. The invention also relates to a composition containing at least one cytochrome C oxydase substrate and/or one agent increasing the expression of said substrate, and at least one compound emitting and/or filtering, in particular under light exposure, a light radiation having at least one predominant wavelength that activates the cytochrome C oxydase. The invention also relates to a kit including at least one composition containing at least one cytochrome C oxydase substrate and/or one agent increasing the expression of said substrate, and at least one device and/or compound emitting and/or filtering a light radiation having at least one predominant wavelength that activates the cytochrome C oxydase.02-24-2011
20120323165MULTIPLE TISSUE LAYER ELECTROPORATION APPLICATOR AND DEVICE - The present invention relates to dual depth electroporation devices capable of electorporating both muscle tissue and skin tissue in a single application in order to generate a broad immune response in a subject, and uses of the same.12-20-2012
20120323164PHOTODYNAMIC THERAPY WITH PHTHALOCYANINES AND RADICAL SOURCES - The use of phthalocyanines together with a free radical source for photodynamic therapy is described. The free radical sources cause the photodecomposition of the phthalocyanines, which can be useful for various reasons such as allowing light to penetrate to lower tissue levels that would otherwise be obscured. The nature of the phthalocyanine and the free radical source chosen can both have an influence on the rate of photodecomposition. The free radical sources can be provided along with the phthalocyanines either in free unattached form, or they can be attached to the phthalocyanines themselves.12-20-2012
20120323163METHODS OF USING DUAL-EFFECT LIPOSOME IN THERAPY - The invention provides a method for treating target in need of such a treatments in a subject, comprising (a) administering a liposome containing a photosensitizer and a drug to a subject and (b) irradiating targets at least one time at appropriate time(s). In particular, the irradiation is performed at least two times.12-20-2012
20120271219Combined Energy and Topical Composition Application For Regulating the Condition of Mammalian Skin - A method for regulating the condition of mammalian skin by the steps of applying a first personal care composition to an area of skin where regulation is desired. The first personal care composition contains a gel composition. In another step energy is delivered to the dermis to heat collagen in the dermis such that the heated collagen in the dermis heats the epidermis and stratum corneum until the stratum corneum reaches an external temperature of from about 37° C. to about 48° C. The energy delivery to the dermis is then controlled to maintain the temperature of the stratum corneum in the range of from about 37° C. to about 48° C.10-25-2012
20120271218DRUG DELIVERY DEVICES AND METHODS WITH COLLIMATED GAS STREAM AND RELEASE-ACTIVATABLE TAPE - Drug delivery devices and methods are provided for delivering a substance into a human or animal tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas. The device also includes a drug source positioned and configured to release a drug into the gas. The drug source includes a release-activatable tape having the drug disposed thereon. The device also includes a first collimator fluidly connected with the gas source. The first collimator, which has an inlet end and an outlet end, is adapted to form a collimated gas stream comprising the drug in the gas.10-25-2012
20120323162Methods and Compositions for Treating Conditions of the Eye - Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature.12-20-2012
20110160640Operation management of active transdermal medicament patch - A transdermal medicament patch includes a flexible substrate having a therapeutic face configured for releasable retention against the skin of a patient, a medicament matrix susceptible to permeation by medicament and secured to the therapeutic face of the substrate, and a return electrode secured to the therapeutic face spaced from the medicament matrix. The return electrode and the medicament matrix effect electrically conductive engagement with the skin of the patient when the substrate is retained thereupon. A power source is carried on substrate so electrically coupled between the medicament matrix and the return electrode as to cause iontophoretic migration of medicament from the medicament matrix into the skin of the patient. A dosage control circuit carried non-removably on said substrate limits to a predetermined medicament quantity the total medicament administered into the skin of the patient by iontophoretic migration during a predetermined therapy period.06-30-2011
20110160639COSMETIC IONTOPHORESIS SYSTEM - Iontophoretically administering a cosmetic agent requires an active electrode and a return electrode secured to the skin (06-30-2011
20110238001NANOPARTICLE BASED PHOTODYNAMIC THERAPY AND METHODS OF MAKING AND USING SAME - A novel method for cancer treatment that combines radiotherapy and photodynamic therapy (PDT). More particularly, luminescent nanoparticles with attached photosensitizers, such as porphyrins, are used as a new type of agent for photodynamic therapy. Upon exposure to ionizing radiation, light will emit from the nanoparticles to activate the photosensitizers; as a consequence, a singlet oxygen is produced to augment the killing of cancer cells by ionizing radiation. No external light is necessary to activate the photosensitizing agent within tumors. The combination of radiotherapy and PDT is more efficient than either used alone.09-29-2011
20110238000POLYMER-CONJUGATED ALBUMIN HYDROGELS FOR CONTROLLED RELEASE OF THERAPEUTIC AGENTS - A hydrogel system comprising polymer-conjugated albumin molecules is provided for controlled release delivery of therapeutic agents. The polymer is a functionalized synthetic polymer, preferably PEG-diacrylate. The polymer-conjugated albumin is preferably mono-PEGylated albumin. The hydrogel system may comprise a matrix to which the polymer-conjugated albumin molecules are linked via a functional group of the polymer. The matrix may be formed from the same polymer of the polymer-albumin conjugate.09-29-2011
20100234794SYSTEM AND METHOD FOR REDUCING SURGICAL SITE INFECTION - A system and method for performing a surgical procedure that are based on delivering air to a surgical site to prevent contamination of a wound or surgical instrument. A curtain of air above the surgical site prevents pathogens or pathogen laden particulates eminating from sources such as the skin of health care professionals including operating room staff, room air, and ceiling from contaminating the surgical site. The curtain of air may be turbulent or laminar and heated or humidified with a solution of anti-microbial agent such as an antibiotic or anti-microbial such as triclosan. Optional incorporation of a UV or blue light source into the system may also prevent infection. The system is designed to be ergonomically compatible with existing surgical substrates such as a retractor, bed, or drape. Sources of sterile air can be brought to a manifold pivotably coupled to a shaft that is attached to a bedrail or instrument stand to deliver the air directly over a surgical site.09-16-2010
20120089077OCULAR IONTOPHORESIS DEVICE - The invention relates to a device of ocular iontophoresis for delivering active substances, comprising a reservoir having an outer wall and a hollow body at least partly delimited by the outer wall, wherein the hollow body is capable of receiving an electrical conductive medium and active substances contained in the medium and has an outlet defining a surface, so-called “application surface”, intended to received a determine part of an eyeball surface, the application surface being at least partly limited by an outer line concave towards the optical axis of the eyeball, wherein the outer wall extends from the outer line with a global outwardly with respect to the said optical axis.04-12-2012
20120089076METHOD FOR TREATING INFLAMMATION - A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.04-12-2012
20120330216METHODS AND APPARATUS FOR SKIN REJUVENATION - Apparatus and methods are provided for the purpose of applying topical treatment on the skin in a standardized and fractionated way. In one aspect of the inventive subject matter, a device includes a trigger activating a pump, which is continuous with a passageway that drains fluid from a reservoir to nozzle. The trigger is operatively coupled to the pump. The pump forces a predetermined volume of fluid to leave the nozzle at a predetermined distance from the skin.12-27-2012
20110301529SYSTEMS, METHODS AND COMPOSITIONS FOR OPTICAL STIMULATION OF TARGET CELLS - Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated NpHR-based molecule comprising a nucleic acid sequence that codes for light-activated NpHR-based molecule and a promoter. Either a high expression of the molecule manifests a toxicity level that is less than about 75%, or the light-activated NpHR-based proteins are expressed using at least two NpHR-based molecular variants. Each of the variants characterized in being useful for expressing a light-activated NpHR-based molecule that responds to light by producing an inhibitory current to dissuade depolarization of the neuron. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion pumps or for controlling inhibitory currents in a cell (e.g., in in vivo and in vitro environments).12-08-2011
20110301528ADMINISTRATION OF ANTIBIOTICS AND THERAPEUTIC AGENTS - Antibiotics are administered in a surgical site subcutaneously via a small or stab incision in the surgical field. Transcutaneous ultrasonic vibrations are applied across the surgical field, which is then opened in the usual manner, to thereby provide a surgical field which contains a vastly higher and more effective level of antibiotic. At the same time the underlying tissue is hydrated.12-08-2011
20110306923IRRITATION-REDUCING OCULAR IONTOPHORESIS DEVICE - The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a pH lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.12-15-2011
20120330219IRRADIATION DEVICE - An irradiation device for insertion into an orifice of the body for providing photodynamic therapy or diagnosis comprises: a housing 12-27-2012
20110319808ANTIMICROBIAL COMPOSITION - A composition for use on skin and wounds, comprising a photo-catalyst which is capable of preferentially staining biofilms the composition being for use in the diagnosis and treatment of biofilms in wounds.12-29-2011
20120330218METHOD FOR IMPROVING FAR-FIELD ACTIVATION IN PERIPHERAL FIELD NERVE STIMULATION - A method of providing therapy to a patient having a disorder using an electrode located adjacent a peripheral target neural region. The method comprises conveying electrical stimulation energy from the electrode that stimulates a first set of nerve endings in the peripheral target neural region. The method further comprises increasing an activation threshold of a second set of nerve endings in the peripheral target neural region, thereby rendering the second set of nerve endings less excitable to the electrical stimulation energy. The first set of nerve endings are relatively far from the electrode and the second set of nerve endings are relatively near the electrode.12-27-2012
20120330217ELECTRODE DEVICE USED IN IONTOPHORESIS TREATMENT - The present invention provides an electrode device used in iontophoresis treatment, in which an electrode layer used for introduction of medication can be contacted to a medication reservoir layer with a simple manner, and in which the medication reservoir layer can be reliably held when the medication is introduced into a skin. A main-electrode layer 12-27-2012
20120101426Method for Transdermal Delivery of Permeant Substances - A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.04-26-2012
20090054829Electrogenic pump molecule control - Activation of electrogenic pump molecules can be realized by a dynamic entrainment procedure which includes two steps: synchronization of individual pump molecules to work at the same pumping pace, and gradual modulation of the synchronization frequency. We studied synchronization of the Na/K pump molecules in a physiological running mode by applying the concept of an electronic synchrotron to the biological system. Both theoretical analysis and experimental results showed that individual Na/K pump molecules can be synchronized by a well designed oscillating electric field. The synchronized pump currents show separated inward and outward pump currents and a magnitude ratio of 3:2 reflecting stoichiometric number of the pump molecules.02-26-2009
20120289885PHOTOTHERAPY SYSTEM - The present application is directed to a phototherapy system for treating a treatment region having a treatment surface. The phototherapy system comprises an optical device. The optical device includes a light source generating source light, an emission surface emitting emitted light, and a sheet waveguide. The light source is coupled to direct the source light into the sheet waveguide. The sheet waveguide has a plurality of light extraction features that direct light out of the sheet waveguide. The emitted light has a wavelength to activate a photoactive compound; the emitted light has a therapeutic radiant emittance. The phototherapy system may comprise a feedback component that measures the light intensity near the treatment surface and provide feedback to adjust the source light. The phototherapy system may further comprise a treatment patch and a photoactive compound within the treatment region.11-15-2012
20120289886CONTROLLED APPLICATION OF CROSS-LINKING AGENT - Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.11-15-2012
20100168646METHOD AND APPARATUS FOR TREATING ISCHEMIC DISEASES - The present invention relates to the treatment of ischemic diseases, and more particularly, to treatment of diabetic retinopathy and ischemia of the retinal and choroidal tissues. The treatment, which will work in vitrectomized eyes as well as non-vitrectomized eyes, is based on selective and fractional electrolysis of the vitreous humor to produce oxygen and optionally active chlorine while simultaneously controlling pH. Oxygen or active chlorine can suppress or reverse the onset of diabetic retinopathy, other retinovascular diseases, and choroidal neovascularization.07-01-2010
20130012864MEDICAL APPARATUS - A medical apparatus includes a storing section in which information concerning a drug movement in a living body is stored, an arithmetic processing section that acquires, based on the information stored in the storing section, information concerning a target region to which a first fluorescent drug is administered, information concerning a method of administering the first fluorescent drug, and information indicating start of administration, diagnosis end timing corresponding to the first fluorescent drug and sets, administration start timing of a second fluorescent drug, and a control section that performs control to start the administration of the second fluorescent drug when a current time reaches the administration start timing of the second fluorescent drug and, after the diagnosis end timing corresponding to the first fluorescent drug, performs control to reduce an irradiating light amount of excitation light for exciting the first fluorescent drug.01-10-2013
20100130910Patches and method for the transdermal delivery of a therapeutically effective amount of iron - Embodiments of the invention provide patches for the transdermal delivery of iron-containing compositions to an individual suffering from an iron deficiency. Many embodiments provide an iontophoretic patch for the transdermal delivery of a therapeutically effective amount of iron. The patch comprises an electrode and a reservoir containing a composition comprising ionic iron for the delivery of the therapeutically effective amount of iron. Various embodiments provide methods of using embodiments of the iontophoretic patch for delivering a therapeutically effective amount of iron to an individual suffering from one more forms of iron deficiency including iron deficiency anemia. Such methods can be used for treating and/or preventing the iron deficiency. The amount of delivered iron can be adjusted depending upon various treatment parameters such as patient weight and type and amount of iron deficiency.05-27-2010
20100130909TREATMENT OF BARRETT'S ESOPHAGUS USING PHOTODYNAMIC THERAPY - A method for treatment of Barrett's esophagus comprising the steps of: injecting HPPH in a physiologically compatible medium into a patient having Barrett's esophagus tissue to provide a dose level of 3 through 5 mg/m05-27-2010
20130018299NANOSHELLS ON POLYMERS - Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.01-17-2013
20130018298Iontophoretic Drug Delivery Packaging - The present invention relates generally to iontophoretic drug delivery systems for transdermal delivery of therapeutic agents and, more particularly, to packaging such systems for long shelf life and easy assembly for use. The system package includes an iontophoretic skin worn patch component that accommodates a power source, electronics, electrodes and a drug pack component that carries a therapeutic agent which is contained as a separate sealed component. The packaged system further provides for ease of assembly at the time of use.01-17-2013
20130023816ELECTRODES, ELECTRODE SYSTEMS, AND METHODS OF MANUFACTURE - Multilayer electrodes, electrode systems, and stimulation systems are disclosed. An electrode may include a conductive layer with a unitary tail, a connector disposed on a distal end of the tail, and a nonconductive top layer disposed along a top portion of the conductive layer. An electrode may include a magnetic lead connector socket, or a receptacle formed by a depression in the conductive layer configured to receive a male connector. An electrode system may include a plurality of conductive zones and a plurality of connectors. A stimulation system may include an electronics layer in electrical contact with a conductive layer via a puncture connection, and may provide an iontophoretic treatment followed by a TENS treatment. Other electrodes, systems and methods are also disclosed.01-24-2013
20130023815SYSTEM AND METHOD FOR BIPHASIC TRANSDERMAL IONTOPHREOTIC DELIVERY OF THERAPEUTIC AGENTS - Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.01-24-2013
20090275877Method of Enhancing Electrotransport Polypeptide Flux By Amino Acid Substitution with Histidine - Methods of modifying polypeptide drugs in order to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by substituting a histidine residue (His) for one or more glutamine (Gln), threonine (Thr) and/or asparagine (Asn) residue(s). The His for Gln substitution is particularly preferred from the standpoint of retaining biological activity of the parent polypeptide. Compositions containing the modified polypeptide, which are useful for transdermal electrotransport delivery, are also provided.11-05-2009
20090299268Topical Aminolevulinic Acid-Photodynamic Therapy for the Treatment of Acne Vulgaris - Light treatments of sebaceous gland disorders with 5-aminolevulinic acid and photodynamic therapy are disclosed. A preferred treatment includes topical application of 5-aminolevulinic acid to the skin followed by light exposures with repeated treatment at various intervals. At low doses of ALA and photodynamic therapy (PDT) in single or multiple treatments, improvement in the sebaceous gland disorder, e.g., acne, provides the discovery that diminishment in sebum secretion and the eradication of bacteria occurs. At high doses of ALA and a single high energy PDT treatment, permanent changes to the sebaceous gland and sebum secretion have been discovered.12-03-2009
20080234629WATER ELECTROLYSIS TO FACILITATE DRUG DELIVERY BY IONTOPHORESIS - The present invention is an iontophoretic system that electrolyzes water to enhance the iontophoretic delivery of an active agent. The invention provides a cartridge adapted for use in iontophoretic system comprising electronics associated with a working electrode capable of electrolyzing water and a conductive composition comprising water and at least one active agent wherein the conductive composition has an initial pH in the absence of the flow of current, wherein upon flow of current through the electrode, water is electrolyzed, and the pH of the composition is changed to a second pH thereby providing enhanced iontophoretic delivery of the active agent.09-25-2008
20080234628MULTIPLE PART ELECTROTRANSPORT DRUG DELIVERY DEVICE - An electrotransport device for delivering a therapeutic agent through a body surface of a patient. The device has an electronic module that can be coupled with a reservoir module to form the electrotransport device. The reservoir module has a reservoir that contains the therapeutic agent for delivery through the body surface by electrotransport. The reservoir module also has a cutout forming a channel having a narrow channel portion and a less narrow channel portion with channel walls. The electronic module has circuitry for electrically driving the therapeutic agent for electrotransport and having a body with a narrow portion and a less narrow portion corresponding to the narrow channel portion and the less narrow channel portion. The narrow portion of the electronic module can be guided into the narrow channel portion through the less narrow channel portion of the reservoir module.09-25-2008
20080234627PIVOTALLY ENGAGED MULTIPLE PART ELECTROTRANSPORT DRUG DELIVERY DEVICE - An electrotransport device for delivering a therapeutic agent through a body surface of a patient. The device has an electronic module that can be coupled with an agent module to form the electrotransport device. The agent module has a compartment containing the therapeutic agent for delivery through the body surface by electrotransport. The agent module has a first end, and includes first agent module (AM) coupler about the first end. The electronic module has a first end and a second end corresponding to the first end and second end of the agent module. The electronic module has a first electronic module (EM) coupler about the first end of the electronic module for coupling with the first AM coupler such that as the first AM coupler matingly engages with the first EM coupler the electronic module and the agent module can be pressed together pivoting about where the first AM coupler engages the first EM coupler. The electronic module includes circuitry for electrically driving the therapeutic agent for electrotransport.09-25-2008
20080234626Multi-stage microporation device - A thermal treatment device for forming a micropore in a barrier has a micro-heater component with at least one micro-heater with a thermal member having a base end and a tip end. The device also has an ablation material in the at least one micro-heater and a power supply component for activating the micro-heater component. The ablation material expands in response to the activation in order to mechanically puncture the barrier to a first depth without thermally inducing ablation of the barrier and the micro-heater component enlarges the first depth of the micropore to a second depth and/or produces an improvement in at least one physiological property of the micropore.09-25-2008
20130178785SYSTEM AND METHOD FOR WOUND HEALING - A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode.07-11-2013
20130178786REMOTE CLOSED-LOOP TITRATION OF DECONGESTIVE THERAPY FOR THE TREATMENT OF ADVANCED HEART FAILURE - An apparatus comprises one or more physiological sensing circuits that generate a sensed physiological signal and at least one of the physiological sensing circuits is implantable, a measurement circuit configured to recurrently measure one or more physiological parameters that indicate a status of heart failure of the subject, a comparison circuit configured to compare the one or more physiological parameter measurements to one or more physiological parameter target values, a therapy circuit configured to control delivery of one or more drugs to treat heart failure, and a control circuit in electrical communication with the comparison circuit and the therapy circuit and configured to recurrently adjust delivery of drug therapy according to the comparison of the measured physiological parameters to the physiological parameter targets.07-11-2013
20130178787Dry Compositions and Devices Containing Such Dry Compostions for Use in Photodynamic Therapy or Photodynamic Diagnosis - This invention relates to dry pharmaceutical compositions comprising an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA, or a pharmaceutically acceptable salt thereof. The compositions may be used in the photodynamic treatment (PDT) or photodynamic diagnosis (PDD) of cancer, pre-cancerous conditions and non-cancerous conditions. The invention relates further to irradiation devices comprising dry compositions and the use of such devices in the photodynamic treatment (PDT) or photodynamic diagnosis (PDD) of cancer, pre-cancerous conditions and non-cancerous conditions.07-11-2013
20080221504APPARATUS AND METHOD FOR TREATING TISSUE - An apparatus and method used for medical and/or cosmetic treatment of a tissue, such as skin tightening, skin laxity and/or wrinkle reduction and or other skin flaws, including an energy source, a vacuum chamber and rollers which may facilitate easy sliding of the apparatus from one treated area to another. The rollers may also prevent excessive friction of the skin during the treatment. The energy source can be configured to emit energy based on the position of the apparatus on the skin (i.e., the position of the rollers), as well as the pressure within the vacuum chamber. The vacuum level and energy emission can be changed or pulsed based on the treatment regime.09-11-2008
20120253261SYSTEMS AND METHODS FOR OPTOGENETIC MODULATION OF CELLS WITHIN A PATIENT - Cells within a patient are optogenetically modulated to treat various neurological disorders. In one example, a method includes delivering a viral vector including a genetic agent encoding for one or more light-sensitive proteins to a delivery site within a patient. The viral vector includes retrograde and/or anterograde transport properties such that the viral vector is configured to transduce the genetic agent into cells at the delivery site and into cells in a plurality of sites proximal and remote to the delivery site. A bioelectrical signal(s) related to a neurological condition of the patient is sensed, e.g. using an implanted electrode. Optical stimulation is delivered to cells transduced with the genetic agent by the viral vector to treat the neurological condition of the patient.10-04-2012
20130096485IRREVERSIBLE ELECTROPORATION USING NANOPARTICLES - The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors. In embodiments, the methods comprise the use of high aspect ratio nanoparticles with or without modified surface chemistry.04-18-2013
20130144204BONE IMPLANT AND SYSTEMS THAT CONTROLLABLY RELEASES SILVER - Silver and/or zinc ion releasing implants, systems and method of operating, inserting and activating/inactivating them are described. In some variations the implant is configured as a bone implant that includes a bone-screw or intramedullary rod like body configured to receive a treatment cartridge having a plurality of ion-releasing members configured as an anode that can controllably engage with a catheter to turn galvanic release of ions on/off as desired. These devices may be configured to release silver ions (and/or zinc ions) above a predetermined level for a predetermined period of time and may maintain a concentration of ions over a relatively large volume of tissue. The ion-releasing members may be configured to reduce or prevent implant movement.06-06-2013
20090099500MULTI-FUNCTION ELECTRODE AND USES THEREOF - The present invention is of an electrode comprising an electrode substrate base layer and a plurality of layers of insoluble pole electroactive substance disposed on the electrode substrate base layer, wherein each of the plurality of layers of insoluble pole electroactive substance is configured to facilitate a treatment of a condition. Further, the present invention is of use of the electrode in a currant generating treatment device.04-16-2009
20080200861APPARATUS AND METHOD FOR SKIN TREATMENT - A device for treatment of skin tissue includes RF electrodes for applying RF energy to the skin and a dispensing unit for dispensing a depilatory substance onto the skin. The device may include a housing, an RF electrode assembly including RF electrodes for applying RF energy to the skin, one or more of the RF electrodes is movable relative to the housing and to the surface of the skin for distributing the RF energy to various parts of the skin and for spreading the depilatory substance along the surface of the skin. The RF electrodes are energized by an internal or external RF energy source. A method for treatment of skin tissue includes applying a depilatory substance to the skin and applying RF energy to the depilatory substance treated skin.08-21-2008
20110213295Methods and Systems for Electrokinetic Delivery of a Substance - A method for delivering a substance to an infected nail of an individual is described. The method includes the step of applying a device to at least one infected nail of an individual, where the device includes at least one active electrode and at least one counter electrode, where the at least one counter electrode is in contact with the individual, and where the device is connected to at least one power source. The method also includes the steps of disposing a medicament between the at least one active electrode and the at least one infected nail, applying a salt solution to the at least one infected nail, and providing an electrical current from the power source to the at least one active electrode to facilitate delivery of the medicament into the region of the at least one infected nail.09-01-2011
20110224598Radiant near infrared light emitting diode exposure as skin preparation - A method for treating inflammatory acne on the skin of a patient, the method comprising irradiating the skin of the patient with radiant infrared light emitting diode (LED) light, subsequently applying ALA onto the skin of the patient and irradiating the ALA treated skin with visible LED light.09-15-2011
20100286592METHOD TO MODULATE CELLULAR REGENERATION POST MYOCARDIAL INFARCT - A system delivers cardiac pacing therapy and chemical and/or biological therapy to modulate myocardial tissue growth in a heart after myocardial infarction (MI). The system includes an agent delivery device to release one or more agents to an MI region to modulate myocardial tissue growth in that region, and a cardiac rhythm management (CRM) device to deliver pacing pulses to enhance the effects of the one or more agents by altering myocardial wall stress and cardiac workload. In one embodiment, the system is an implantable system including an implantable agent delivery device and an implantable CRM device.11-11-2010
20100286591Dispensing Device and Method for Forming Material - A dispensing device and method for forming a least partially solid or gel-like material from a liquid. At least one liquid issuing from an outlet is subjected to an electric field causing the liquid to form at least one electrically charged jet which, after formation, forms a fiber (F) or breaks up into fiber fragments (FF) or particles (D). The thus formed at least partially solid or gel-like material may be directly deposited, by virtue of the energy in the electrical field, onto a surface area, for example an area of skin enabling, for example, formation of a dressing for a wound or burn which is of high specific area and extremely absorbent. A biologically active ingredient such as a pharmaceutical ingredient or biological matter such as DNA may be incorporated into the fibers (F), fragments (FF) or particles (D). Fibrils, particles or microcapsules incorporating a biologically active ingredient may be supplied for oral or nasal administration to an animal such as a human being.11-11-2010
20100286590IONTOPHORETIC DEVICE WITH IMPROVED COUNTERELECTRODE - The present disclosure relates to an iontophoretic device. In one aspect, the device includes a barrier layer between the drug reservoir and wearer. In another aspect, the device includes a counterelectrode opposite the driving electrode relative to the drug reservoir.11-11-2010
20100286589Atherosclerotic Plaque Dissolution Composition - A method and chemical composition for modifying and dissolving atherosclerotic plaques formed in blood vessels of a patient is provided. The chemical composition comprising one or more of an organic substance, an inorganic substance, and a bioactive product is administered at sites of the plaques formed in the patient's blood vessels. The chemical composition comprises, for example, one or more of d-limonene, propylene glycol, octanic acid, 2-octane, and glycerine. The chemical composition enables modification of the plaques by altering composition of the plaques. The modification comprises partial dissolution, complete dissolution or elimination of the plaques. The modification makes the plaques amenable to different forms of plaque treatment, for example, balloon angioplasty, stenting, atherectomy, etc. The modified plaques are eliminated from the body of the patient. The modification or elimination of the plaques facilitates treatment of cardiovascular diseases caused due to plaques formed in the blood vessels of the patient.11-11-2010
20100286588MAGNETIC PATCH COUPLING - Apparatus is described for facilitating delivery of a substance through skin (11-11-2010
20100286587SUBLINGUAL ELECTRICAL DRUG DELIVERY - Apparatus is provided that includes an oral housing, which is configured to be placed at least partially in a mouth of a subject, and which comprises a drug, and two or more electrodes. The apparatus further includes a power supply, and circuitry coupled to the power supply and the electrodes, and configured to drive the electrodes to drive, into oral tissue of the subject, a current having a frequency of between 30 and 300 kHz. Other embodiments are also described.11-11-2010
20110275982METHOD FOR INJECTING DRUG INTO LIVING BODY BY ELECTROSPRAYING AND DEVICE THEREOF - The present invention provides a method whereby a drug can be conveniently injected into the living body, without sticking a needle, from a device that is not in contact with the living body, and a device therefor. Specifically provided is a method for injecting a peptide drug such as insulin, and a device therefor. No special consumables are needed except the drug solution or suspension. The method and device comprise injecting a drug into the living body by electrospraying a solution or suspension of the drug from a nozzle to which high voltage is applied and which is not in contact with the living body.11-10-2011
20110275981ELECTRODE ASSEMBLY FOR DELIVERING A THERAPEUTIC AGENT INTO OCULAR TISSUE - A contact electrode assembly for delivering at least one therapeutic agent into ocular tissue of a subject includes a flexible dielectric layer, a first electrode portion, and a second electrode portion. The flexible dielectric includes oppositely disposed first and second surfaces. The first electrode portion is disposed on the first surface of the dielectric layer. The second electrode portion is disposed on a portion of the second surface of the dielectric layer. The second electrode portion includes an interdigitated electrode having a first comb-shaped portion defining a first plurality of fingers and a second comb-shaped portion defining a second plurality of fingers. Each of the first electrode portion, the first comb-shaped portion, and the second comb-shaped portion is electrically connectable to a signal source.11-10-2011
20110275980MEDICAL DEVICES EMPLOYING ELECTROACTIVE POLYMERS FOR DELIVERY OF PARTICULATE THERAPEUTIC AGENTS - In accordance with one aspect, medical devices are provided which comprise an electroactive polymer material and therapeutic-agent containing particles. The device is configured such that the particles are delivered from the device upon actuation of the electroactive polymer material.11-10-2011
20110275979METHOD/DEVICE FOR TRANSDERMAL VASCULAR TREATMENT - Devices and transdermal methods are provided for safe and effective therapeutic treatment of the venous system, such as varicose veins. Present invention provides non-invasive and minimally invasive transdermal methods for treating varicose and spider veins, comprising the use of a radiation source in combination with a chemical fluid/composition to safely and more effectively close or shrink vein walls, providing a transdermal therapeutic method for varicose veins until now only treated with surgery or endovascular laser treatments. In a preferred embodiment a device comprises a radiation source, preferably of wavelength between about 980 and 1940 nm, being effective in causing shrinkage of the vein treated. In other preferred embodiments methods comprise the transdermal delivery of a chemical composition through a patch or gel or the injection of a chemical fluid, preferably a hypertonic solution, to the vein under treatment; and simultaneously or after a dwell time, irradiating with a radiation source transdermally. The treatment performed with the present invention results in blood vessel wall damaged, eventually closing the vein, in lesser time with practically no pain or discomfort to the patient during and after the therapy.11-10-2011
20110275978Devices and systems that deliver nitric oxide - The present disclosure relates to dressings, such as patches and bandages, and other devices and systems that deliver nitric oxide.11-10-2011
20100318018WOUND HEALING ELECTRODE SET - The set for the electrical stimulation of a patient, comprises a backing, at least one electrically active zone and a wire connected to said electrically active zone for connection to a stimulator. Said backing has the shape of a bandage or of a plaster.12-16-2010
20100318017Method of improving vision using contact lenses and corneal collagen crosslinking - A method of improving vision by reshaping the cornea to correct for abnormal surface curvature by measuring the surface topography of the cornea, providing a rigid contact lens to reshape the cornea into a more desirable configuration, wearing the contact lens for sufficient time to achieve the reshaping, removing the contact lens, applying an alcohol solution to the epithelial layer, applying a riboflavin solution to the cornea, and subjecting the cornea to UV light for sufficient time to induce cross-linking of collagen fibers within the cornea, whereby the cornea is stabilized in the reshaped desirable configuration.12-16-2010
20120283623PHOTOTHERAPY PATCH - A phototherapy patch is disclosed, which includes: an adhesive layer, having a first surface and an opposite second surface; a pharmaceutical drug layer, disposed on the first surface of the adhesive layer; and a spontaneous emission layer, disposed over the pharmaceutical drug layer and capable of emitting therapeutic light by light illumination or a chemical reaction. Accordingly, the phototherapy patch according to the present invention has no power supply disposed therein, and thereby is suitable to be manufactured as a particularly thin and thus inconspicuous device.11-08-2012
20120283622DERMATOLOGICAL TREATMENT DEVICE - The invention relates to a dermatological treatment device suitable primarily for treating nail fungus, in particular toenail fungus. The use of a photochemically active substance allows effective control of the fungus by irradiating with light at a wavelength that is relatively harmless to health. Potential technical implementations are possible for setting up the irradiation device, utilizing either a gas discharge lamp or LEDs as the light source. A shoe-shaped optical shielding housing is preferably used, being transparent in the long-wavelength portion of the visible spectrum, and absorptive in the short-wavelength, therapeutic range of the spectrum.11-08-2012
20120283621STERILIZING APPLICATION OF CROSS-LINKING AGENT - A method for treating an eye includes applying, to an outer protective layer of an area of an eye, one or more initial doses of a cross-linking agent that acts as a photosensitizer. The method also includes delivering, from a light source, one or more initial doses of ultraviolet light to the area of the eye. The cross-linking agent increases absorption of the ultraviolet light by the area of the eye, and the absorption of the ultraviolet light sterilizes the area of the eye before the outer protective layer is penetrated. Additionally, the method includes penetrating the outer protective layer of the eye to provide access to an area below the outer protective layer. Moreover, the method includes applying a treatment to the eye via the access provided by cutting the outer protective layer. In some embodiments, the cross-linking agent is Riboflavin, and the treatment is LASIK surgery.11-08-2012
20120283620TREATMENT UTILIZING HYDROPHOBIC WEAK BASES CHEMOTHERAPEUTIC AGENTS AND ILLUMINATION - Hydrophobic weak base compounds such as hydrophobic weak base chemotherapeutic agents (which are not an anthracycline) for use in the treatment of medical conditions such as proliferative disease or disorder in a subject, in combination with illumination of a region in a body of the subject which is characterized by the presence of proliferating cells, are disclosed. The hydrophobic weak base compound and a wavelength of illumination are selected such that the hydrophobic weak base compound acts as a therapeutically effective photosensitizer when exposed to the illumination.11-08-2012
20120283619MINIMALLY INVASIVE CONTRACEPTION METHOD AND DEVICE - Minimally invasive methods and devices for endoluminally treating female fallopian tubes or male vas deferens of mammals are presented as a permanent method of contraception. In preferred embodiments, medical devices for male and female sterilization comprise laser radiation source operating at one or more preselected wavelengths between about 980 nm and about 1950 nm, preferably at least one of 980 nm, 1470 nm and 1950 nm; treatment waveguide with a radial or cylindrical radiation emitting tip; viewing scope; and a temperature sensor. In another preferred embodiment, a minimally-invasive permanent contraception method for males and females comprises the steps of introducing at least one treatment waveguide in a body cavity; positioning the treatment waveguide inside a body cavity; irradiating; and repeating the procedure in companion body cavity to inhibit fertilization. In another embodiment, fluids are infused and/or extracted after, before or during the procedure to enhance laser energy absorption and enhance efficiency of laser treatment.11-08-2012
20130184636System and Method for Controlling Neural and Muscular Function - A system and method for controlling neural and muscular function is disclosed in which opsins are introduced into a neural circuit such that the control of optical signals transmitted to the opsins results in the control of neural and muscular functions. Specifically disclosed is the control of the bladder, bowel, and sexual functions of a human.07-18-2013
20130184637TREATING CANCER USING ELECTROMAGNETIC FIELDS IN COMBINATION WITH PHOTODYNAMIC THERAPY - A light generating circuit is implanted in a subject's body and aimed at a target region such as a tumor. A photosensitizer is introduced into the target region, and an AC electric field is induced in the region. The field causes the light generating circuit to generate light, which activates the photosensitizer; and at certain field strengths and frequencies, the field itself has a beneficial effect. The beneficial effects of the field and the activated photosensitizer are thereby obtained simultaneously.07-18-2013
20110288465CANCER SURGERY AND TARGETED KILLING - Cancer treatment is improved by performing fluorescence-guided surgery and cell killing mediated by fluorescent proteins individually or together.11-24-2011
20130190677PHOTO-STIMULATION METHOD AND KIT WITH AGONIST AGENT - Disclosed is a photo-stimulation method employing an agonist agent, and a kit for introducing same. The method includes the following steps: providing a light-emitting diode (LED) illuminant which is a yellow, red, green, blue LED or a mixture of two or more kinds thereof, and an agonist agent which contains 0.5% to 2% calcium ion; and adding the agonist agent to a subject and illuminating the subject by the LED illuminant to promote collagen synthesis, to suppress microbial growth, or to inhibit melanin synthesis, wherein the yellow LED is in an illuminance range from 1,000 to 3,500 lux, the red LED is in an illuminance range from 6,000 to 9,500 lux, the green LED is in an illuminance range from 1000 to 5000 lux, and the blue LED is in an illuminance range from 3,000 to 7,000 lux.07-25-2013
20130190678PERSONALIZABLE SYSTEM AND METHOD FOR ANESTHETIZING THE TYMPANIC MEMBRANE - Systems and methods are provided for anesthetizing a tympanic membrane of an ear. The systems are personalizable to ensure proper anesthetizing solution administration. The systems and methods may also be useful for administering a solution to the ear canal of a human patient and for maintaining the solution therein.07-25-2013
20120289887ELECTROTRANSPORT DEVICES, METHODS AND DRUG ELECTRODE ASSEMBLIES - A drug electrode assembly usefully employed in an electrotransport device for the delivery of drugs across a tissue surface includes an electrode, a drug reservoir which stores the drug (including an ionized (e.g., anionic) or neutrally charged drug species), and a liquid impermeable solid-state assist ion conducting barrier layer interposed between the electrode and the drug reservoir. The barrier layer can be a single-ion conductor of a specific (unique) species of ion called the assist ion. During drug delivery, the assist ion moves across the barrier layer into or out of the drug reservoir, and as the assist ion crosses the barrier layer/drug reservoir interphase, the drug species moves to the tissue surface. The assist ion can be, for example, sodium ions (Na11-15-2012
20090292237Modular Drug Delivery System for Minimizing Trauma During and After Insertion of a Cochlear Lead - A system for delivering therapeutic agents to biological tissue includes a surgically implantable lead configured to be inserted into the biological tissue, the surgically implantable lead including a preformed cavity; and a modular capsule containing a therapeutic agent which includes dexamethasone base; the modular capsule being secured within the preformed cavity; the modular capsule releasing the therapeutic agent into the biological tissue. A method of delivering therapeutic agents to biological tissue includes obtaining a surgically implantable lead with a preformed cavity; obtaining a modular capsule containing a therapeutic agent comprising dexamethasone base and securing it within the preformed cavity; and inserting the surgically implantable lead into the biological tissue.11-26-2009
20120029420COMBINATION AND ELEECTRICAL STIMULATING AND INFUSION MEDICAL DEVICE AND METHOD - A combined electrical and chemical stimulation lead is especially adapted for providing treatment to the spine and nervous system. The stimulation lead includes electrodes that may be selectively positioned along various portions of the stimulation lead in order to precisely direct electrical energy to ablate or electrically stimulate the target tissue. The invention also includes a method of activating electrodes in the electrical stimulation lead whereby an ablative lesion can be formed in a desired shape and size. The invention further includes a method of managing pain in a sacrum of a patient, and a method of assembling an electrical stimulation device.02-02-2012
20120029419TREATING CANCER USING ELECTROMAGNETIC FIELDS IN COMBINATION WITH OTHER TREATMENT REGIMENS - Chemotherapeutic treatment for certain cancers may be combined with low intensity, intermediate frequency alternating electric fields that are tuned to a particular type of target cell. When the tuned fields were combined with Paclitaxel, Doxorubicin or Cyclophosphamide, excellent results were obtained against human breast cancer cells (MDA-MB-231) and non-small cell lung (H1299) carcinomas in culture. More specifically, cell proliferation inhibition similar to that obtained by drug alone was reached by exposure to the combined treatment at drug concentrations between one and two orders of magnitude lower than for drug-only regimens of treatment.02-02-2012
20120029418COMPOSITION AND METHOD FOR PHOTODYNAMIC DISINFECTION - The present invention includes a composition for photoablation comprising a photosensitizer and ethylenediaminetetraacetic acid (“EDTA”) at a very low concentration (e.g., ranging from about 0.01 mM to about 1.25 mM), wherein the composition is used for photoablation of at least one targeted organism. The present invention also includes a method for photoablation comprising applying the composition to a treatment site containing at least one targeted organism and applying light to the treatment site at a wavelength absorbed by the photosensitizer so as to inhibit the at least one targeted organism.02-02-2012
20120029417COSMETIC TREATMENT METHOD INCLUDING THE PROJECTION OF AN IMAGE ONTO THE ZONE TO BE TREATED - A treatment method for treating human keratinous material, the method including: a) projecting an image onto a zone to be treated; b) modifying the content and/or adjusting the projected image; and c) cosmetically treating the zone as a function of the image as modified and/or adjusted in this way.02-02-2012
20120029416POROUS ELECTROACTIVE HYDROGELS AND USES THEREOF - The present invention provides porous electroactive hydrogels, the deformation angle of which is controlled by electroactuation, and methods for preparing and using such hydrogels.02-02-2012
20130197424LEAD AND METHODS FOR BRAIN MONITORING AND MODULATION - An apparatus, a system and methods for modulating and monitoring tissue have an elongate member with proximal and distal ends and a plurality of annular stimulating electrodes axially arranged along the elongate member. The stimulating electrodes are disposed near the distal end and are adapted to pass current into tissue. At least one of the annular stimulating electrodes has at least three independent stimulation points on the electrode. The apparatus also includes a plurality of recording electrodes that are adapted to measure local tissue potentials and a plurality of conductors are coupled with the recording and stimulating electrodes. An optional multiple contact connecting terminal may be coupled with the conductors and is disposed near the proximal end of the elongate member.08-01-2013
20130197425CURRENT CAGE FOR REDUCTION OF A NON-TARGET TISSUE EXPOSURE TO ELECTRIC FIELDS IN ELECTROPORATION BASED TREATMENT - The invention shows the relation between the volumes of tissue that experiences muscle contraction inducing electric fields, V08-01-2013
20130204178TRANSDERMAL DELIVERY DEVICE - A device includes a dispensing mechanism that is operable to dispense a substance from a canister that is connected to the device. The device includes at least one iontophoresis electrode that is chargeable to generate an electric field to enable transdermal delivery of an active ingredient of the substance when the substance is dispensed onto skin.08-08-2013
20120065577Device and Methods for Enhanced Multi-Delivery of Biologically Active Substances into an Organism and to Prevent Local Irritation - Transnasal delivery of medication directly to a patient's brain is achieved using an iontophoresis wire cooperable with a medication administration device. A controller regulates an electric charge to the iontophoresis wire. The iontophoresis wire is insertable into each nasal cavity. This wire is preferably encased in a tube, through which the medication will be transnasally delivered. A cleaning solution may also be delivered to the nasal cavity after treatment to reduce irritation from the iontophoresis.03-15-2012
20130096486Activatable Drug Dispensing System - The invention relates to a system (04-18-2013
20080319371METHOD AND SYSTEM FOR TREATING OF ONYCHOMYCOSIS WITH AN APPLICATOR HAVING A GEL MEDICAMENT LAYER - A method to electrokinetically deliver a medicament to a nail of a mammalian user including: forming a cast of the nail of the user wherein the cast is a reverse impression of the nail; applying a medicament matrix to the nail; sandwiching the medicament matrix between the cast and the nail; pressing the medicament matrix to the nail using the cast; applying electrical current to an electrical current path extending through the medicament matrix and the nail, and delivering medicament from the matrix into the nail by electrokinetic transporting the medicament along the current path.12-25-2008
20120095388MATERIAL FOR FACILITATING THERMAL TREATMENTS OF BIOLOGICAL TISSUES AND METHOD OF ENERGY TARGETING LEADING TO THERMAL TREATMENT OF BIOLOGICAL TISSUES - A method includes positioning an effective amount of a thermal target material at a treatment site of a patient. The treatment site, that is, the location of the thermal target material, comprises a location adjacent to biological tissue to be treated. The thermal target material includes carbon molecules preferably in a carrier fluid. Regardless of the particular structure of the carbon, the carbon molecules in the material heat very rapidly in response to incident microwave radiation and radiate heat energy. The heat energy radiated from an effective amount of the thermal target material when subjected to an effective quantity of microwave energy causes localized heating around the thermal target material. This localized heating may be applied for therapeutic purposes. However, the microwave radiation necessary to produce therapeutically effective heating is insufficient to cause cellular damage in the biological tissue by direct absorption in the tissue.04-19-2012
20120095387METHODS FOR DETECTION, DIAGNOSIS AND SELECTIVE ERADICATION OF NEOPLASMS IN VIVO USING MULTIDOMAIN BIOTAGS - A method for treating cancer in a subject is provided, the method comprising administering to the subject an effective dose of a multidomain biotag that targets one or more cancer cells; and exposing the subject to one or more rounds of radiation. The one or more rounds of radiation kills the one or more cancer cells targeted by the biotag, but, in general, do not kill healthy cells or kills a negligible number of healthy cells.04-19-2012
20120095386COMPOSITION AND DEVICE STRUCTURE FOR IONTOPHORESIS - Device structure 04-19-2012