| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 600012000 | Magnetic element placed within body (e.g., injected, inserted, implanted, etc.) | 63 |
| 20110196187 | MAGNETICALLY SENSITIVE DRUG CARRIERS AND DELIVERY DEVICES - Apparatuses for delivering compositions of matter comprising a magnetically sensitive drug carrier and a related drug and methods for causing the drug carriers to localize within the patient using an internal or external magnetic field are described. | 08-11-2011 |
| 20120184799 | Device and method for correcting obstructive sleep apnea - An orthotic obstructive sleep apnea treatment device is provided that includes a hyoid bone attachment element disposed to attach a ferric element to a hyoid bone, where the ferric element is disposed to face along a treatment vector from the hyoid bone, and the treatment vector is oriented relative to a sagittal plane of a human. The orthotic obstructive sleep apnea treatment device further includes an external orthotic neck device having a contoured housing with a shape disposed to conform about a neck of the human subject, where the housing includes a force delivery element disposed at an exterior-front neck region of the human subject and is disposed to provide an attractive force to the ferric element along the treatment vector. A force sensor is disposed to measure a force exerted on the hyoid bone, a skin contact pressure, tissue compression between the ferric element and the force delivery element. | 07-19-2012 |
| 20090043148 | Use of magnetic implants to treat body tissue structrues - Plural (at least two) magnetic devices are implanted in a patient so that magnetic interaction between those devices modifies the patient's body in one or more respects (e.g., by modifying the shape and/or performance of some part of the body). Prior to implantation, a location in the body may be marked for later reference during the implantation. The magnetism of one or more of the magnetic devices may be changed in vivo after implantation. One or more of the implanted devices may be subsequently removed from the patient if desired. Use of the magnetic devices inside tissue conduits (e.g., as a treatment for GERD) is especially considered by way of illustration. | 02-12-2009 |
| 20130090516 | Local Anesthesia By Magnet-Directed Concentration of Nanoparticle Conjugated Anesthetic - Methods and formulations for induction of local anesthetic effects employing magnetic nanoparticles conjugated to anesthetic molecules. Magnetic nanoparticle-local anesthetic conjugates may be safely injected intravenously into human and animal subjects without encountering the deleterious effects observed with traditional injections of local anesthetics. The magnetic nanoparticle-local anesthetic conjugate may be concentrated at a site of action through the application of an external magnetic field to the patient at a site where local anesthesia is desired. | 04-11-2013 |
| 20090306455 | Method of Providing Magnetised Particles at a Location - A method of providing magnetised particles at a location using particles which can be switched between magnetic and non-magnetic states by exposure to a suitable magnetic field. The method comprises conveying the particles in their non-magnetic state to the location; and then exposing the particles to the suitable magnetic field so that they switch to their magnetic state. | 12-10-2009 |
| 20120226094 | TARGETING ORTHOPAEDIC DEVICE LANDMARKS - Targeting sensors for use in targeting landmarks of orthopaedic devices. The sensors include a non-cylindrical mounting platform such as a printed circuit board and at least two mounted or printed sensor coils to provide a low profile sensor assembly which can be placed in a predetermined position and orientation on or in an orthopaedic device. The platform has a non-circular cross-section having an aspect ratio of greater than about 1.5:1. The non-circular cross-section of the platform enables the sensor to be placed in a known fixed position within the implant. The sensor coils may be partially or fully embedded in the platform. | 09-06-2012 |
| 20120197062 | URETER TO ILEAL CONDUIT ANASTOMOSIS USING MAGNETIC COMPRESSION AND RELATED DELIVERY DEVICES AND METHODS - Magnetic compression anastomosis can be carried out by placing cooperating magnets, one in the ileal conduit and one in the ureter, to lock together and form the anastomosis. The magnets may be placed to form a side-to-side anastomosis. At least one of the magnets can include radioactive material. Catheters may be used to place the magnets, and the catheters may have at least one deflatable or retractable tissue spacer. | 08-02-2012 |
| 20080293995 | MAGNETIC DEVICES AND METHODS FOR RESHAPING HEART ANATOMY - Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Heart dilation treated by reshaping the heart anatomy with the use of magnetic forces. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The magnetic forces are applied with the use of one or more magnetic elements which are implanted within the heart tissue or attached externally and/or internally to a surface of the heart. The various charges of the magnetic forces interact causing the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the force of the magnetic elements, allowing the damaging effects of heart dilation to slow in progression or reverse. | 11-27-2008 |
| 20090131737 | Lumen-traveling biological interface device and method of use - Lumen-traveling biological interface devices and associated methods and systems are described. Lumen-traveling biological interface devices capable of traveling within a body lumen may include a propelling mechanism to produce movement of the lumen-traveling device within the lumen, electrodes or other electromagnetic transducers for detecting biological signals and electrodes, coils or other electromagnetic transducers for delivering electromagnetic stimuli to stimulus responsive tissues. Lumen-traveling biological interface devices may also include additional components such as sensors, an active portion, and/or control circuitry. | 05-21-2009 |
| 20110288363 | Biologically Enhanced Irrigants - Compositions, systems and methods utilizing engineered surgical irrigants providing delivery of components with therapeutic or other secondary benefits. Engineered irrigants provide targeted delivery of desired agents, including agents for propulsion of nano-devices, agents including molecular probes, gene expression agents, magnetically orientable agents, agents for discrete tissue temperature detection and tissue regeneration agents. | 11-24-2011 |
| 20120190912 | SYSTEM FOR CORRELATING ENERGY FIELD CHARACTERISTICS WITH TARGET PARTICLE CHARACTERISTICS IN THE APPLICATION OF AN ENERGY FIELD TO A LIVING ORGANISM FOR IMAGING AND TREATMENT OF INVASIVE AGENTS - The Energy Field and Target Correlation System automatically correlates the characteristics of target particles and a living organism to compute the characteristics of an energy field that is applied to a living organism to activate the target particles which are bound to or consumed or taken up by invasive agents in the living organism to produce detectable effects which can be used to image and treat the invasive agents. The energy field must be crafted to properly control the response and localize the extent of the illumination. The System automatically selects a set of energy field characteristics, including: field type, frequency, field strength, duration, field modulation, repetition frequency, beam size, and focal point. The determined energy field characteristics then are used to activate field generators to generate the desired energy field. | 07-26-2012 |
| 20090099403 | Implant Magnet Insertion and Removal Tools - A magnet positioning tool is described for use with an implantable device. The device has a pair of opposing positioning surfaces, at least one of which has a magnet cradle for mechanically engaging an implant magnet associated with a magnet position in the implantable device. The tool also includes a position engagement surface for engaging the implantable device when the magnet cradle is adjacent to the magnet position. | 04-16-2009 |
| 20090124848 | Receptacles for Implanted Device Control Magnets, and Associated Systems and Methods - Receptacles for implanted device control magnets, and associated systems and methods are disclosed. A system in accordance with one embodiment includes a magnet receptacle that in turn has a first portion with a first magnetically conductive material and a second portion with a second magnetically conductive material. At least one of the first and second portions can be moveable relative to the other between a closed configuration and an open configuration, with the first and second portions forming a cavity when in the closed configuration, and with the first magnetically conductive material proximate to a first side of the cavity and the second magnetically conductive material proximate to a second side of the cavity facing toward the first side. | 05-14-2009 |
| 20100280304 | Magnetic Gastric Reduction Device - A magnetic gastric reduction device includes magnetic elements adapted to couple to a stomach and a sensor adapted to detect stomach properties. The device also includes a control device operably coupled to the magnetic elements. The control device is adapted to operably communicate with the sensor and is configured to control the magnetic elements based on a property of the stomach detected by the sensor to cause the magnetic elements to selectively compress or decompress the stomach. | 11-04-2010 |
| 20120296149 | METHODS OF CONTROLLING MAGNETIC NANOPARTICLES TO IMPROVE VASCULAR FLOW - Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. | 11-22-2012 |
| 20090137859 | PASSAGE EXPANSION DEVICE FOR PATIENTS - A method for opening a portion of a passageway of a patient is disclosed. The patient has a first metallic structure attached to a portion of the patient's neck. The method includes obtaining a second magnetic structure, placing the second magnetic structure proximate the first metallic structure attached to the portion of the patient's neck, and pulling the second magnetic structure away from the patient's neck to thereby open the passageway. | 05-28-2009 |
| 20090131738 | Lumen-traveling biological interface device and method of use - Lumen-traveling biological interface devices and associated methods and systems are described. Lumen-traveling biological interface devices capable of traveling within a body lumen may include a propelling mechanism to produce movement of the lumen-traveling device within the lumen, electrodes or other electromagnetic transducers for detecting biological signals and electrodes, coils or other electromagnetic transducers for delivering electromagnetic stimuli to stimulus responsive tissues. Lumen-traveling biological interface devices may also include additional components such as sensors, an active portion, and/or control circuitry. | 05-21-2009 |
| 20080281144 | Skin Pressure Reduction to Prevent Decubitus Ulcers by Partial Magnetic Levitation - A magnetic levitation system for immobile patients in a wheelchair is disclosed. A magnet multi-pole configuration that is mechanically stable is provided that lifts the body and/or load shifts (rotates the body from side to side) the body. Based on a multi-pole configuration of permanent magnets in the pelvis, a corresponding multi-pole configuration for magnet repulsion is placed below the patient, typically as part of the wheelchair. Alternatively, a unipolar repulsion with mechanical patient restraint is implemented to achieve body lift or levitation. Either permanent magnets or electromagnets, optionally with magnetic sensor-mediated active computerized feedback control below the body, are sufficient to implement a complete multi-pole repulsive configuration that is mechanically stable. The apparatus reduces compressive force on soft tissues disposed between a human pelvis and a wheelchair seat. | 11-13-2008 |
| 20090030261 | DRUG DELIVERY SYSTEM - Currently, no efficient, non-invasive methods exist for delivering drugs and/or other therapeutic agents to the interior of the eye to treat or prevent disease or injury. The present invention relates to a novel method that is suitable for the delivery of any therapeutic agent (suitably modified) to the interior of the eye without the need for the penetration of a needle into the eyeball. In a preferred embodiment, it involves an injection into a peripheral vein (or oral administration, or administration by some other enteral or parenteral route) of a solution of inert drug which is trapped in the eye by a magnetic field and activated by radiation once it is in position, so that the active agent is released only where it is needed and can have its therapeutic effect without affecting other tissues or organs. The inert drug may be composed of a biologically compatible magnetic nanoparticle chemically bound to a specially inactivated (caged) form of the drug to be delivered and to a luminescent marker. | 01-29-2009 |
| 20080306324 | MAGNETIC JOINT IMPLANT - The application is directed to devices and methods where one or more magnetic or magnetizable implants provides therapeutic benefits to a patient. The implant may be useful for expanding the range of motion of joints or dynamically providing different responses to changing conditions in the body where the implant is placed. An electromagnet is placed on or in a bone on one side of a joint, and another electromagnet or magnetically active material is placed on or in a bone on the opposing side of the joint. The electromagnet may be continuously energized to relieve pressure in the joint space, or may be energized in response to forces applied to the joint. | 12-11-2008 |
| 20090054722 | Drug Carrier Containing Magnetic Fine Particles and System Using the Same - The present invention provides drug carriers having high heating efficiency by high-frequency dielectric heating in a state of being selectively accumulated in a target site. The drug carriers each consist of a drug, magnetic fine particles, and a shell containing the drug and the magnetic fine particles. The shell has an outer diameter in a range from 10 nm to 200 nm. The magnetic fine particles having an average particle diameter of d has a standard deviation σ of particle diameter distribution satisfying 0.8d>σ>0.4d. The magnetic fine particles contained in the individual drug carriers generate hysteresis heat due to high-frequency dielectric heating by irradiation of a high-frequency magnetic field. | 02-26-2009 |
| 20090192344 | SURGICAL DEVICES FOR MANIPULATING TISSUE - A surgical kit can be used to manipulate tissue within the body of a patient to create a working space within the body to allow a surgeon to easily access and work within the body using various surgical instruments. A surgical kit can include an implant comprised of a magnetic material which can be engaged with tissue within the body. The kit can further include a surgical instrument having a magnet which can be used to manipulate the implant and tissue engaged therewith. A surgical kit can include an anchor and a hanger configured to engage tissue at different locations within the body and a connection member engaged with the anchor and the hanger such that the connection member can be pulled to move the anchor toward the hanger. A surgical instrument which utilizes a vacuum provided to one or more movable members can also be used to manipulate tissue. | 07-30-2009 |
| 20100210893 | APPARATUS AND METHOD FOR ELECTROMAGNETIC TREATMENT OF PLANT, ANIMAL, AND HUMAN TISSUE, ORGANS, CELLS, AND MOLECULES - An apparatus and method for electromagnetic treatment of plants, animals, and humans comprising: configuring at least one waveform according to a mathematical model having at least one waveform parameter, said at least one waveform to be coupled to a target pathway structure; choosing a value of said at least one waveform parameter so that said at least waveform is configured to be detectable in said target pathway structure above background activity in said target pathway structure; generating an electromagnetic signal from said configured at least one waveform; and coupling said electromagnetic signal to said target pathway structure using a coupling device. | 08-19-2010 |
| 20100004500 | SYSTEMS AND METHODS FOR VARYING ELECTROMAGNETIC AND ADJUNCTIVE NEURAL THERAPIES - Systems and methods for varying electromagnetic and adjunctive neural therapies are disclosed. A method in accordance with one embodiment includes applying electromagnetic signals to a target neural population of a patient over a first period of time in accordance with a first mode (e.g., including signal delivery to the central nervous system or peripheral nervous system, via implanted or non-implanted devices). The method can further include applying electromagnetic stimulation to the patient over a second period of time in accordance with a second mode different than the first mode. Varying the mode between the first period of time and second period of time can increase the efficacy and/or longevity of the stimulation. Systems in accordance with other embodiments can support multiple signal delivery devices. | 01-07-2010 |
| 20090112048 | Medical or veterinary digestive tract utilization systems and methods - Systems and methods are described for implementing or deploying medical or veterinary utility modules (a) operable for mooring at least partly within a digestive tract, (b) small enough to pass through the tract per vias naturales and including a wireless-control component, (c) having one or more attachment protrusions positionable adjacent to a mucous membrane, (d) configured to facilitate redundant modes of attachment, (e) facilitating a “primary” material supply deployable within a stomach for an extended and/or controllable period, (f) moored by one or more adaptable extender modules supported by a subject's head or neck, and/or (g) configured to facilitate supporting at least a sensor within a subject's body lumen for up to a day or more. | 04-30-2009 |
| 20110172486 | MAGNETIC MICROBUBBLES, METHODS OF PREPARING THEM AND THEIR USES - The invention provides a method of preparing a suspension of microbubbles for use in a carrier liquid, wherein the microbubbles have a gas core and a liquid shell, said liquid shell comprising magnetic nanoparticles, and wherein the microbubbles satisfy the following conditions: (i) the force due to buoyancy (F | 07-14-2011 |
| 20110034753 | STEM CELL TARGETING AND ACTIVATION USING MAGNETIC PARTICLES - The present invention provides a method of selectively activating and/or targeting stem cells which enables the cells to then be manipulated mechanically in a remote manner wherein the method comprises magnetically manipulating a stem cell in vivo or in vitro by the association of a magnetisable particle within the stem cell. | 02-10-2011 |
| 20110054237 | Methods and Systems for Magnetic Focusing of Therapeutic, Diagnostic or Prophylactic Agents to Deep Targets - Systems and methods are disclosed for trapping or focusing magnetizable particles comprising therapeutic agents at a distance using a dynamic magnetic field and feedback control, to enable the treatment of diseased areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas deep within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents. | 03-03-2011 |
| 20110245581 | METHOD AND APPARATUS FOR THROMBUS REMOVAL USING MAGNETIC PARTICLES - A method and system for affecting a thrombus after ischemic stroke. The method may include injecting a plurality of magnetic particles into a bloodstream and moving or distorting a thrombus formed or lodged in the bloodstream using a magnetic force to manipulate the magnetic particles. The method may include conjugating ferromagnetic particles, paramagnetic particles, or superparamagnetic particles to a thrombus-specific attachment agent such as an anti-fibrin antibody, and injecting the conjugated particles into the bloodstream. Thereafter, the thrombus may be agitated, broken apart, or dissolved using a magnetic field to exert a magnetic force on the conjugated particles. The method may also include injecting a thrombolytic agent into the bloodstream to interact with and further dissolve the thrombus. | 10-06-2011 |
| 20100063346 | MAGNETORHEOLOGICAL FLUIDS AND THERAPEUTIC USES THEREOF - In some embodiments, the present disclosure provides methods for stimulating a subject's immune system. Particular methods provide a tumor specific immune response by injecting a tumor with a magnetorheological fluid and applying a magnetic field to the tumor. The immune response can be used to treat disseminated tumors or metastatic cells. Further methods induce a general immune response, such as by treating a section of tissue, such as healthy tissue, with a magnetorheological fluid and applying a magnetic field to the treated tissue. The immune response can be used to treat illness or disease or to enhance the effect of a therapeutic agent. In particular examples, the disclosed methods are used to enhance the effect of immuno stimulants. Also provided are methods for causing necrosis of a cell mass, such as a tumor, by injecting a magnetorheological fluid into a section of tissue and applying a magnetic field to the tissue. | 03-11-2010 |
| 20090216066 | MAGNETICALLY ASSISTED MEDICATION DELIVERY METHOD - A tracheal tube positioning apparatus is located relative to a patient's trachea by engaging the patient's Adam's apple. Indicia on relatively movable sections of the positioning apparatus provides an indication of the distance between the patient's mouth and the patient's larynx. A flexible guide rod is moved through a distance corresponding to the distance between the patient's mouth and larynx, as determined by the positioning apparatus. A magnet is utilized to attract a leading end portion of the guide rod. A plurality of emitters may be disposed in an array around the patient's Adam's apple. Outputs from the emitters are detected by a detector connected with the guide rod and by a detector connected with the tracheal tube. Alternatively, a plurality of detectors may be disposed in an array around the patient's Adam's apple to detect the output from an emitter connected with the guide rod and by an emitter connected with the tracheal tube. Expandable elements may be connected with the guide rod and/or tracheal tube to steer movement along an insertion path. | 08-27-2009 |
| 20120302820 | DEVICE AND METHOD FOR OPENING VASCULAR OBSTRUCTIONS - The present invention is directed to a device and method for opening obstructed body internal passages and for sensing and characterizing tissues and substances in contact with the device. In general, the device comprises a catheter tube capable of inducing vibrations in a guidewire contained therein, wherein said vibrations of the guidewire are utilized for opening a passage through an occlusion. The in-vivo vibrations may be induced by means of a magnetic field actuating means and a guidewire comprising magnetic coupling means, or by means of transducers, which may be also used for the sensing. The invention also relates to the field of minimal invasive catheterization, particularly an apparatus for opening and/or removing obstructions occluding body internal passages by means of an active guidewire comprising a coil to which an alternating voltage can be applied. In that way the guidewire can vibrate if an external magnetic field is applied. | 11-29-2012 |
| 20080255404 | MEDICAL DEVICE AND USING METHOD THEREOF - Disclosed herein is a medical device including: a positioning catheter to be inserted into a blood vessel in the vicinity of an affected region; a treatment catheter to be inserted to reach the affected region; and attracting means provided at respective predetermined positions of both the catheters to apply a magnetic force in a direction of attracting each other; wherein the magnetic force of the attracting means restricts floating of the treatment catheter. | 10-16-2008 |
| 20110118534 | METHOD AND SYSTEM FOR NEUROLOGICAL TREATMENT - The present invention provides a system and method for neurological treatment. The system of the invention includes a neurological stimulation (NS) modality that delivers neurological stimulation to a first brain region and a cognitive training (CT) that delivers CT to a second brain region, where activation of the CT modality occurs at a predetermined time relative to the activation period of the NS modality. In one embodiment, the NS and CT are interlaced. The first and second brain regions may be the same brain regions or different brain regions. The invention may be used, for example, in the treatment of dementia, neurological conditions or psychiatric conditions. | 05-19-2011 |
| 20110071335 | APPLICATIONS OF ALTERNATING MAGNETIC FIELDS ON MAGNETIC NANOPARTICLES - Embodiments include applying or generating an alternating magnetic field near an affected area of a subject to be treated. When magnetic nanoparticles are located in the affected area, the magnetic nanoparticles are oscillated by the alternating magnetic field, which causes the magnetic nanoparticles to be dispersed within the affected area, break up the affected area, and/or heat the affected area. | 03-24-2011 |
| 20110263924 | FUNCTIONALIZED MAGNETIC NANOPARTICLE ANALYTE SENSOR - A method and system for simply and efficiently determining quantities of a preselected material in a particular solution by the placement of at least one superparamagnetic nanoparticle having a specified functionalized organic material connected thereto into a particular sample solution, wherein preselected analytes attach to the functionalized organic groups, these superparamagnetic nanoparticles are then collected at a collection site and analyzed for the presence of a particular analyte. | 10-27-2011 |
| 20100280303 | DEVICES AND METHODS FOR TREATING MAGNETIC POISONING AND/OR MAGNETICALLY INDUCED ROULEAUX - A medical device including a Rouleaux degausser that directs a degaussing magnetic field to a patient's blood flow. The degaussing magnetic field reduces magnetically-induced Rouleaux and/or Red Blood Cell aggregation. The device also has a power source for supplying power to the Rouleaux degausser. | 11-04-2010 |
| 20100099941 | METHOD OF HYPERTHEMIA TREATMENT - Magnetic nanoparticle compositions are provided which provide an inherent temperature regulator for use in magnetic heating, particularly for use in magnetic hyperthermia medical treatments. The composition includes magnetic nanoparticles having a Curie temperature of between 40 and 46° C., preferably about 42° C., and may further include a polymeric material and optionally a drug or radiosensitizing agent. Methods of hyperthermia treatment of a patient in need thereof are provided which include administering to the patient a composition comprising magnetic nanoparticles having a Curie temperature of between 40 and 46° C.; and exposing the magnetic nanoparticles in the patient to an alternating magnetic field effective to generate hysteresis heat in the nanoparticles. | 04-22-2010 |
| 20120116148 | MAGNETIC-ASSISTED TUMOR CONFINEMENT METHODOLOGY AND EQUIPMENT - Disclosed embodiments are directed to reducing the likelihood of intra-operative shedding. Specifically, disclosed embodiments utilize injected magnetic nanoparticles and magnets to confine tumor cells to the surgical bed in order to prevent the cells from being released into the general circulation and/or lymphatics. | 05-10-2012 |
| 20120310034 | DEVICES FOR CONTROLLING MAGNETIC NANOPARTICLES TO TREAT FLUID OBSTRUCTIONS - The present invention relates to a system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator. In one aspect, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels. | 12-06-2012 |
| 20120157751 | INTRACORONARY DEVICE AND METHOD OF USE THEREOF - Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems. | 06-21-2012 |
| 20120157750 | Targeted Delivery of Magnetically Tagged Active Agents in Combination with Negative Pressure Wound Therapy - Methods and systems for treating a wound using targeted delivery of magnetically-tagged active agents in combination with negative pressure wound therapy are presented. In particular, a magnetically-active wound insert may be used to attract magnetically-tagged stem cells to a wound site to treat the wound. | 06-21-2012 |
| 20110077450 | MAGNETIC REINFORCING AND REDUCING ACUPUNCTURE METHOD EMPLOYING THE IONIZATION TENDENCY OF METALS - The present invention relates to a magnetic reinforcing and reducing acupuncture method employing the ionization tendency of metals, wherein, in the N pole of a permanent magnet, metal ions having a low ionization tendency are used and a large number of metal ions are impregnated into the body together with the magnetic N pole; and, in the S pole of the permanent magnet, a metal having a high ionization tendency is used so that noxious vapor from within the body escapes by means of the metallic ions with the S pole. | 03-31-2011 |
| 20090287036 | Methods And Systems For Using Therapeutic, Diagnostic or Prophylactic Magnetic Agents - Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treatment of diseased areas including areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents. | 11-19-2009 |
| 20110105825 | Nanoparticle-sized magnetic absorption enhancers having three-dimensional geometries adapted for improved diagnostics and hyperthermic treatment - Nanoparticle-sized magnetic absorption enhancers (MAEs) that exhibit a controlled response to a magnetic field, including a controlled mechanical response and inductive thermal response. The MAEs have a magnetic material that exhibits the inductive thermal response to the magnetic field and is embedded in a coating, such that the MAE conforms to a particular shape, e.g., a hemisphere, a dome or a shell, that is chosen to produce the desired controlled mechanical response of the entire MAE to the magnetic field. A targeting moiety for specifically binding the MAE to a pathogen target is also provided. The MAEs are preferably bound by a flexible linker to promote the desired mechanical response, which includes interactions between MAEs that are not bound to their pathogen target for the purpose of forming spheres, spherical shells, or generally spherical dimers. Such forms contain the thermal energy produced by the thermal inductive response of the magnetic material and thus reduce collateral healthy tissue damage during hyperthermic treatment. The inventing extends to appropriate apparatus and methods for diagnostics and hyperthermic treatments employing the MAEs. | 05-05-2011 |
| 20090131736 | SPINAL INJURY IMAGING BY MAGNETICALLY LEVITATED SENSORS - A system for detecting a spinal injury region containing injured spinal nerve cells may include a swarm of nanosensors that are configured to detect chemical signals released by the injured spinal nerve cells, and are coated with a magnetic material. A magnetic field generator may controllably generate a magnetic field so as to magnetically levitate the magnetically coated nanosensors. An imaging subsystem may detect the positions of the nanosensors. A controller may control the intensity and direction of the magnetic field in a feedback loop, in response to the detected positions of the nanosensors, so that the attractive force that attracts each nanosensor toward the injured spinal cell as a result of the chemical affinity of the nanosensor is iteratively supplemented by the magnetic levitation force applied to that nanosensor, until substantially all of the nanosensors are agglutinated around the spinal injury region. | 05-21-2009 |
| 20120232329 | MAGNETIC-BASED METHODS FOR TREATING VESSEL OBSTRUCTIONS - Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. | 09-13-2012 |
| 20120136195 | DRUG DELIVERY SYSTEM OF TARGET DRUG AND METHOD OF IMPLEMENTING THE SAME - A drug delivery system of a target drug and method of implementing the same. Said drug delivery system of target drug comprising: a plurality of drug-carrying magnetic particles, a magnetic field generation device, and an ultrasound generation device. Said magnetic field generation device generates a magnetic field to guide said magnetic particles to a target activity position; and said ultrasound generation device generates ultrasound to make said magnetic particles into a suspension state, thus increasing reaction area, enhancing local reaction of drug, such that local retention of drug is able to achieve maximum therapeutic effects at reduced drug dosage. | 05-31-2012 |
| 20120253102 | EXTERNAL MAGNETIC FORCE FOR TARGETED CELL DELIVERY WITH ENHANCED CELL RETENTION - Disclosed herein are compositions and methods for the improved delivery of cells to a target tissue. In some embodiments, the compositions comprise stem cells, in particular cardiac stem cells, and the target tissue is damaged or diseased cardiac tissue. In several embodiments, the methods, in combination with the compositions, yield enhanced delivery, retention, and/or engraftment of the cells into the target tissue, thereby inducing improved functional recovery. | 10-04-2012 |
| 20120226093 | MAGNETIC-BASED SYSTEMS FOR TREATING OCCLUDED VESSELS - Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. | 09-06-2012 |
| 20120226092 | INTRA-SUBJECT MEDICAL SYSTEM, METHOD OF OPERATING BODY-INSERTABLE APPARATUS AND OPERATIVE TREATMENT - Provided is an intra-subject medical system which includes a body-insertable device and a physical quantity generator. The body-insertable device is to be introduced into a subject, is covered by a capsule-shaped exterior member, and includes a physical quantity detecting member which has a directivity to detect a predetermined physical quantity; at least one functional member which has a necessary function for examining or treating inside the subject; and a switch control unit which controls an on/off states or operation mode of the at least one functional member when the physical quantity detecting member detects a physical quantity. The physical quantity generator has a physical quantity emitting unit which emits a temporary physical quantity inside the subject; and a physical quantity direction changing unit which changes an emission direction of the physical quantity. | 09-06-2012 |
| 20120259154 | In Vivo Immunomagnetic Hyperthermia Platform for Any Cell or Virus Having a Target Surface Receptor - The invention is a nano-entity conjugate for use in an in vivo immunomagnetic hyperthermia system for the detection and treatment of any cell or virus having a target surface receptor which encompasses a technology platform that can be used for both real-time monitoring of any cell or virus having a target surface receptor and as a delivery platform for certain types of treatment that are conducive for in vivo applications. The system allows of cell or virus enumeration; cell or virus capture; and cell or virus removal from the patient's circulatory system in-vivo using immunomagnetic hyperthermia. The application of immunomagnetic hyperthermia may actually diminish and eventually stop the progression of cancer and other blood borne or blood affected diseases. | 10-11-2012 |
| 20120259155 | MAGNETIC BODY AND DRUG DELIVERY CONTROL DEVICE USING MAGNETIC BODY - A magnetic body may be suitably applied to a drug delivery system using magnetism. Furthermore, a drug delivery control device allows the magnetic body to be suitably applied to drug delivery. The magnetic body includes a magnet and a cover part attached to an edge of the magnet. The cover part is composed of a material with high magnetic permeability, and a ratio of a length to a radius of the cover part is 10:1 to 7:3. The drug delivery control device includes the magnetic body, a head for supporting the magnetic body and a drive mechanism of the head that causes the head to operate along a projected region formed by the affected area with respect to a surface of a tissue. A magnetic field is applied from the magnetic body to the affected area where a magnetic drug is administered. | 10-11-2012 |
| 20120232328 | DRUG ACTIVATION SYSTEM - The present invention discloses a drug activator carrier comprising: a) particles having a metallic or metallic oxide core prepared from a paramagnetic material, said metallic core being coated with a coating material selected from polymer, metal or metal oxide; b) a biological material, having reductase activity, bound onto the metal coating the particles of step a), and wherein said biological material is capable of activating non-toxic pro-drugs into active and toxic drugs suitable for treating a disease; said drug activator carrier allowing targeted delivery of the toxic drug. | 09-13-2012 |
| 20120265001 | COMPOSITE MAGNETIC NANOPARTICLE DRUG DELIVERY SYSTEM - A composite magnetic nanoparticle drug delivery system provides targeted controlled release chemotherapies for cancerous tumors and inflammatory diseases. The magnetic nanoparticle includes a biocompatible and biodegradable polymer, a magnetic nanoparticle, the biological targeting agent human serum albumin, and a therapeutic pharmaceutical composition. The composite nanoparticles are prepared by oil-in-oil emulsion/solvent evaporation and high shear mixing. An externally applied magnetic field draws the magnetic nanoparticles to affected areas. The biological targeting agent draws the nanoparticles into the affected tissues. Polymer degradation provides controlled time release delivery of the pharmaceutical agent. | 10-18-2012 |
| 20110275880 | Lumen-traveling biological interface device and method of use - Lumen-traveling biological interface devices and associated methods and systems are described. Lumen-traveling biological interface devices capable of traveling within a body lumen may include a propelling mechanism to produce movement of the lumen-traveling device within the lumen, electrodes or other electromagnetic transducers for detecting biological signals and electrodes, coils or other electromagnetic transducers for delivering electromagnetic stimuli to stimulus responsive tissues. Lumen-traveling biological interface devices may also include additional components such as sensors, an active portion, and/or control circuitry. | 11-10-2011 |
| 20110275879 | MAGNETIC FORCE DEVICES, SYSTEMS, AND METHODS FOR RESISTING TISSUE COLLAPSE WITHIN THE PHARYNGEAL CONDUIT - Devices, systems and methods employ magnetic force to resist tissue collapse in targeted pharyngeal structures and individual anatomic components within the pharyngeal conduit during sleep. | 11-10-2011 |
| 20120330089 | OPEN FIELD SYSTEM FOR MAGNETIC SURGERY - A system of navigating a magnetic medical device within that part of a patient located within an operating region of the system, the system comprising magnets, and preferably electromagnets, arranged to provide a magnetic field sufficient to navigate the magnetic medical device within the operating region. There are preferably three magnetic coils arranged in mutually perpendicular planes such that their axes intersect in the operating region. The magnetic coils are sized and arranged so that a patient can easily access the operating region to allow virtually any portion of the patient to be positioned within the operating region. The openness of the magnetic system allows access to the operating region by a bi-planer imaging system. | 12-27-2012 |
| 20120283505 | DRUG, DRUG GUIDANCE SYSTEM, MAGNETIC DETECTION SYSTEM, AND DRUG DESIGN METHOD - It is intended to provide a drug delivery system which makes it possible to solve the existing technical problems and is easily usable in practice. A drug, which comprises an organic compound or an inorganic compound and has been magnetized by modifying a side chain and/or crosslinking side chains, is induced by a magnetic force into target tissues or an affected part. | 11-08-2012 |
| 20120283504 | Biocompatible, Magnetic Nanoparticles for Treating Glioblastomae - The present invention relates to the use of biocompatible, magnetic nanoparticles for the therapy of glioblastomae in a static magnetic field. The magnetic nanoparticles according to the invention have already been in use in the diagnostics of pathological processes for several years. According to the invention, the biocompatible, magnetic nanoparticles are used for the targeted displacement of migrating cancer cells in an external magnetic field (magneto axis), in order to make said cells accessible as a collective to surgical intervention or hyperthermia. | 11-08-2012 |
| 20130012758 | MAGNETICALLY-CONTROLLABLE NANOMETRIC POROUS DRUG CARRIER - The present invention discloses a magnetically-controllable nanometric porous drug carrier, wherein an organic or inorganic matrix is used to carry the drug, and wherein magnetic nanoparticles having magnetosensitivity are used to encapsulate the surface of the matrix and seal the drug inside the matrix. An external magnetic field is used to control the removal rate of the magnetic nanoparticles and control the behavior and rate of drug release. | 01-10-2013 |
| 20090299127 | Magnet-Field Controlled Active Substance Transfer for Aerosol Therapy - The present invention relates to aerosols containing magnetic particles, wherein the aerosols comprise magnetic particles and a pharmaceutical active agent. The invention furthermore relates to the use of such aerosols containing magnetic particles for directed magnetic field-guided transfer of the active agents contained therein in aerosol therapy. | 12-03-2009 |
| 20100286468 | TRANSCRANIAL MAGNETIC STIMULATION WITH PROTECTION OF MAGNET-ADJACENT STRUCTURES - System and methods for Transcranial Magnetic Stimulation (TMS) are described in which regions adjacent (e.g., to the sides and behind the TMS electromagnet) are protected from the high magnetic fields emitted by the TMS electromagnet. Thus, adjacent muscle or neural structures are protected and undesirable side effects are avoid or minimized, allowing stimulation from previously unavailable sites such as the mouth and pharynx. | 11-11-2010 |
