Class / Patent application number | Description | Number of patent applications / Date published |
600010000 | Radio frequency wave induced magnetic field for subcutaneous hyperthermia | 22 |
20080221385 | HYPERTHERMIA TREATMENT DEVICE WITH X-RAY COMPUTED TOMOGRAPHY IMAGING - A medical technology device has an x-ray CT imaging system and a magnet system for generation of a radio-frequency alternating magnetic field for treatment of a tumor injected with ferrite nanoparticles, the x-ray CT system and the magnet system being combined to form a unitary structure. Imaging and tumor therapy can be conducted with one apparatus, and the monitoring of the course of the tumor therapy is simplified. | 09-11-2008 |
20080249350 | Inductive heating of tissues using alternating magnetic fields and uses thereof - The present invention improves the cosmetic appearance of skin by controllably heating a superficial layer of skin thereby inducing acute tissue contraction or shrinkage and a wound response leading to the production of biomolecules, all of which result in improved cosmesis. The invention incorporates a source of radiofrequency electrical energy coupled to coil, with requisite impedance matching network, thereby resulting in the production of an alternating magnetic field. When tissue is brought into proximity of the alternating magnetic field, inductive heating of the tissue results as a consequence of either or both of dipole formation and oscillation, and eddy current formation. Optionally, cooling is provided to remove heat from the coil, the source of radiofrequency electrical energy, or the surface of the skin alone or in combination. The invention exhibits the significant benefits of, among other things, being non-invasive, not requiring electrical contact with the body of the subject, and providing controllable heating only to a thin layer of tissue. | 10-09-2008 |
20080255403 | MAGNETIC NANOPARTICLE THERAPIES - Various compositions, methods, and devices are provided that use fluorescent nanoparticles, which can function as markers, indicators, and light sources. The fluorescent nanoparticles can be formed from a fluorophore core surrounded by a biocompatible shell, such as a silica shell. In one embodiment, the fluorescent nanoparticles can be delivered to tissue to mark the tissue, enable identification and location of the tissue, and/or illuminate an area surrounding the tissue. In another embodiment, the fluorescent nanoparticles can be used on a device or implant to locate the device or implant in the body, indicate an orientation of the device or implant, and/or illuminate an area surrounding the device or implant. The fluorescent nanoparticles can also be used to provide a therapeutic effect. | 10-16-2008 |
20090124847 | COMBINED ENDOCARDIAL AND EPICARDIAL MAGNETICALLY COUPLED ABLATION DEVICE - A device for automatically aligning bipolar electrodes on opposing sides of operative tissue is provided for performing minimally invasive RF ablation. The device includes complementary magnetic electrode assemblies, each having a permanent magnet mechanically coupled to and electrically insulated from an electrical conductor. When positioned on opposing sides of tissue such as an atrial wall, the complementary assemblies automatically align their respective electrical conductors through mutual magnetic attraction to complete an electrical circuit. Each electrical conductor may provide an alignable elongated transmitting element adjacent to a magnetic coupling surface to allow for ablation of linear segments of tissue. Each electrode assembly includes mechanical linkage for coupling to an intracorporeal positioning device and a wire receiving terminal for connection to an external generator. | 05-14-2009 |
20100113861 | METALLIC NANOPARTICLES WITH COATED SHELLS AND APPLICATIONS OF SAME - A process or method for treating cancer. In one embodiment, the method includes the steps of providing a plurality of metallic nanoparticles, wherein each of the plurality of metallic nanoparticles has a core formed with a first metallic material, and a shell formed with a non-metallic material containing carbon, and wherein the shell is formed to enclose the metallic core completely, introducing said metallic nanoparticles into a mammal such that said metallic nanoparticles selectively target at least one type of cancerous cell, and subsequently applying at least one radio frequency of electromagnetic waves to said mammal for a period of time effective to induce skin currents in the cores of the first metallic material of said metallic nanoparticles to cause heat generated locally around targeted at least one type of cancerous cell to kill said cancerous cell. | 05-06-2010 |
20110160515 | ALTERNATING MAGNETIC FIELD APPLICATION DEVICE FOR HEATING MAGNETIC OR MAGNETIZABLE SUBSTANCES IN BIOLOGICAL TISSUE - The invention relates to an alternating magnetic field application device for heating magnetic or magnetizable substances in biological tissue, in particular for thermal therapy using magnetic nanoparticles, composed of a large applicator ( | 06-30-2011 |
20110224479 | EDDY CURRENT INDUCED HYPERTHERMIA USING CONDUCTIVE PARTICLES - Technologies are generally described for hyperthermia based treatment of diseased tissues using conductive particles. Conductive particles of known composition and size distribution may be implanted in diseased tissue and exposed to an alternating magnetic field, which may be tuned to the size of the metal particles to induce eddy currents producing heat in the implanted particles. As the temperature of the metal particles increases, their resistance also increases due to their positive temperature coefficient of resistivity. An antenna placed externally to the body near metal particles may be part of a tuned RF circuit and scanned for resonance. The change either in resonance frequency or circuit impedance may provide tuned feedback, which may be used to control the hyperthermia treatment. | 09-15-2011 |
20120010454 | SYSTEM AND METHOD FOR HYPERTHERMIC TUMOR TREATMENT - A system to induce hyperthermia in a selected portion of the body utilizes permanent magnets mounted on a variable speed motor. A conductive button is positioned at a location proximate the target tissue to be heated, such as a tumor. The magnetic rotor assembly is positioned at a selected distance from the conductive button and rotated at a desired frequency to produce a changing permanent magnetic field that induces an eddy current on the surface of the conductive button. A temperature sensor may be positioned near the conductive button as a feedback mechanism to a control circuit. At higher magnetic polarity frequencies, the conductive button may be implemented in the form of metallic nanoparticles. In this embodiment, the nanoparticles may include molecular elements that selectively bind with the target tissue and thereby accumulate at the target tissue prior to the introduction of the rotating magnetic field. | 01-12-2012 |
20120157749 | HEAT THERAPY - A heat therapy for thermally treating a target tissue within a living body by using a treating apparatus including a treating device with a magnetic part is provided. The magnetic part is heated to a first temperature by a high frequency electromagnetic field with a heating rate ranging from 1 to 5° C./sec, wherein the magnetic part is contacted the target tissue. Temperature controlling steps are performed to the magnetic part having the first temperature, and therefore the magnetic part has a final temperature higher than the first temperature, and a treatment is performed to the target tissue under the final temperature. Each of the temperature controlling steps is a heating step, a cooling step or a temperature conservation step, and the magnetic part is heated or cooled by the high frequency electromagnetic field with a heating rate or a cooling rate ranging from 1 to 5° C./sec. | 06-21-2012 |
20120190911 | LOW TEMPERATURE HYPERTHERMIA SYSTEM FOR THERAPEUTIC TREATMENT OF INVASIVE AGENTS - The Low Temperature Hyperthermia System illuminates nano-particles, which are implanted in a living organism at the locus of the cancer or into the cancer cells, with a precisely determined energy field. This energy field ensures that the optimal cancer cell and cancer stem cell destruction temperature of 42° C. is not exceeded in the tissue, which minimizes the release of Heat Shock Proteins and cancer stem cells. The Low Temperature Hyperthermia System uses specially designed nano-particles that exhibit a specific temperature rise in a given illumination energy field and then have no further temperature rise even if the applied illumination energy field increases beyond the optimal level. Alternatively, the nano-particles exhibit a tightly controlled temperature rise based on a pre-determined illumination energy field strength. This innovative approach can also use radiation and/or chemotherapy in conjunction with the nano-particle illumination to kill the majority of the cancer cells. | 07-26-2012 |
20120209053 | Electromagnetic Thermotherapeutic Apparatus - An electromagnetic thermotherapeutic apparatus includes: a plurality of needle units respectively having head portions and needle portions; a base unit having a base plate that is formed with a plurality of first through holes, and a base pad that is formed with a plurality of second through holes, the needle portions of the needle units removably extending through the second and first through holes, the head portions of the needle units abutting against the base pad; a temperature monitor disposed between the base plate and the base pad; an upper unit disposed above the base pad and abutting against the head portions; and a clamp unit clamping and pressing the base unit against the upper unit. | 08-16-2012 |
20120265000 | Systems and Methods to Reduce Power Deposition in Tissue Exposed to Radio Frequency Electromagnetic Fields - An apparatus for exposing a region of interest of an object, animal or person to an alternating magnetic field has a source of radio-frequency electromagnetic radiation arranged to provide the alternating magnetic field in an exposure volume defined by the apparatus, and a shield arranged between the source of radio-frequency electromagnetic radiation and the exposure volume. The shield includes a material that has a sufficient thickness and arrangement to reduce power deposition to at least regions outside of the region of interest of the object, animal or person during exposure in the exposure volume. | 10-18-2012 |
20130053619 | TREATMENT OF CANCER IN BODY CAVITIES AND PARTS THAT ARE CAVITY-LIKE - The Body Cavity Cancer Treatment System achieves extremely uniform temperatures inside the tissue of the body cavity thereby realizing optimal efficacy in enhancing operation of the chemotherapy agent while avoiding harm or pain to the patient. This is accomplished by the inclusion of “target particles”, such as nano-particles, into the body cavity along with the chemotherapy agent to enable the use of an externally generated energy field to cause heating of the chemotherapy agent and the surrounding tissue of the body cavity by the activation of the nano-particles. The proper selection of the applied energy field enables precise control of the heat generated by the movement of the nano-particles. | 02-28-2013 |
20130053620 | APPARATUS FOR THE GENERATION OF AN ENERGY FIELD FOR THE TREATMENT OF CANCER IN BODY CAVITIES AND PARTS THAT ARE CAVITY-LIKE - The Body Cavity Cancer Treatment Apparatus generates the magnetic field for use in a combined “Low Temperature Hyperthermia” and ionizing radiation and/or chemotherapy cancer treatment protocol. Unlike other competing systems, the Body Cavity Cancer Treatment Apparatus does not directly kill or ablate the cancer cells with killing temperatures rather, the Body Cavity Cancer Treatment Apparatus stresses the cancer and cancer stem cells by keeping them at a nominal 42° Celsius for some period of time via the heating of nano-particles that have been infused into the bladder, using the generated magnetic field. | 02-28-2013 |
20130178691 | Electrically lossy magnetic liquid composition for controlled tissue heating - A dental floss apparatus comprised of a pair of handles that are configured for engagement with the fingers with strands of flossing substrate extending therebetween. The flossing substrates are spaced from each other, running substantially parallel and extending within an opening formed between the ends of the handles. A dissolvable substrate is positioned within this opening through an engagement with one or both of the handles or the flossing substrate, and upon contact with the surface of the teeth, dissolves, and deposits a residue on the surface of the teeth and the surrounding area of the mouth. The dissolvable substrate may be formed of two substrate pieces with a central gap between them defining a means for targeting insertion of the substrate between adjacent teeth and may be colorized or luminescent and have an additive material such as mouthwash, breath freshener, cooling agent, or flavor. | 07-11-2013 |
20130237742 | Electromagnetic Field Applicator Array with Integral Sensors for Implicit Correction of Mutual Coupling and Mismatch - The invention concerns a system for producing. specific field distributions in a defined volume or region. The system comprises an array of electromagnetic field generating elements each with an integrated sensor for measuring the phase and amplitude of the current flowing in a metallic element (antenna or coil) or field in a slot based element, a measurement device to enable measurement of both phase and amplitude of the electrical signals from the sensors with sufficient dynamic range for quantification of the signal, a multi channel radio frequency power source with individually controllable amplitude and phase to excite each of the electromagnetic field generating elements, and a feedback controller enabling controlled adjustment of the amplitude and phase of the radio frequency power source based on the signals from the sensors. The system controls the outputs of a multi channel radio frequency power source such that the current in a metallic or the field in a slot based electromagnetic field generating elements provide the desired electromagnetic field values and the superposition of the fields produced by each electromagnetic field generating element produces said specific electromagnetic field distribution in said defined volume or region. As the signal picked up by each sensor is directly related to the phase and amplitude of the current or field in the associated electromagnetic field generating element and hence the electromagnetic field generated by the array elements, where the current or field measured is the sum of both the applied (from the radio frequency power source) and secondary excitations from mutual coupling and reflections hence the measured value represents the ideal excitation in the absence of mutual coupling, reflections and mismatch. The feedback controller modifies the direct excitation such that the total excitation is the ideal array excitation without coupling or mismatch. The invention implicitly corrects for the coupling and mismatch without explicit knowledge of, and calculation based on, the mutual coupling and mismatch, termed the coupling matrix, such that changes in the coupling matrix due to presence of objects or changes thereof are inherently taken into account. Additionally, by sequentially exciting each element in turn the invention can directly determine the exact mutual coupling matrix of the array even in the presence of variations in source impedance and undefined cable lengths such that initial excitation amplitudes and phases can be calculated to allow rapid adjustment to the desired values. A particular application of interest is in radio frequency hyperthermia applicator systems. | 09-12-2013 |
20140012063 | TISSUE HEATING PREDICTION USING FEEDPOINT EM FIELD DETERMINATION - The accuracy of tissue heating in a body when using a phased array hyperthermia system can be improved by using, in conjunction with the hyperthermia system, a program for predicting heating patterns within the tissue based upon a selected E-field value at each of the antenna energy feedpoints. The hyperthermia system includes circuitry necessary to provide information for calculating the complete EM field at each of the antenna feedpoints during treatment, and such calculated actual feedpoint EM fields are feed to the program to be used in place of the otherwise program generated e-fields in predicting the heating pattern produced by the hyperthermia system during treatment. Further initial operating parameters of the hyperthermia system can be set to produce calculated actual EM fields at the antenna feedpoints which approximate the E-field values used by the program in pretreatment optimizing of the heating pattern. | 01-09-2014 |
20140081069 | DEEP MAGNETIC FIELD GENERATING APPARATUS - A deep magnetic field generating apparatus includes a first coil unit and a second coil unit. The second coil unit is connected with the first coil unit, and disposed around the first coil unit horizontally. Accordingly, the deep magnetic field generating apparatus can generate a desired deep magnetic field. | 03-20-2014 |
20140249351 | MICROPARTICLES FOR SELECTIVELY TARGETED HYPERTHERMIA - A microparticle composition(s) comprising nanomagnetic particles and a matrix, wherein said microparticle composition(s) have a least one of the following properties: (a) a VAR of at least about 1 Watts/cm3 subject to appropriate field conditions; (b) a density of about 2.7 or less: or (c) a size of about 100 nm to about 200 microns. | 09-04-2014 |
20150335743 | MAGNETIC NANOSTRUCTURES AS THERANOSTIC AGENTS - The present invention relates to magnetic nanostructures as theranostic agents, which provide dual function as diagnostic and therapeutic agents. In particular, the present invention relates to compositions comprising magnetic nanostructures and their use as targeted therapeutic agents for cancers (e.g., medulloblastoma) and Alzheimer's disease and related diseases and conditions. | 11-26-2015 |
20150367140 | APPARATUS FOR THE GENERATION OF AN ENERGY FIELD FOR THE TREATMENT OF CANCER IN BODY CAVITIES AND PARTS THAT ARE CAVITY-LIKE - The Body Cavity Cancer Treatment Apparatus generates the magnetic field for use in a combined “Low Temperature Hyperthermia” and ionizing radiation and/or chemotherapy cancer treatment protocol. Unlike other competing systems, the Body Cavity Cancer Treatment Apparatus docs not directly kill or ablate the cancer cells with killing temperatures rather, the Body Cavity Cancer Treatment Apparatus stresses the cancer and cancer stem cells by keeping them at a nominal 42° Celsius for some period of time via the heating of nano-particles that have been infused into the bladder, using the generated magnetic field. | 12-24-2015 |
20160184600 | MAGNETIC EXCITATION DEVICE AND ELECTROMAGNETIC THERMAL ABLATION APPARATUS CONTAINING THE SAME - A magnetic excitation device for an electromagnetic thermal ablation apparatus includes a magnetic unit and two coil units. The magnetic unit has two magnetic induction ends that are spaced apart from each other. The coil units are respectively disposed around the magnetic induction ends. Each of the coil units has two connection parts connectible to an alternating electric power source for generating an alternating magnetic field. | 06-30-2016 |